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    Wyświetlanie 1-8 z 8
    Tytuł:
    Phenotypic screening of the 'Kurz-box' of chemicals identifies two compounds (BLK127 and HBK4) with anthelmintic activity in vitro against parasitic larval stages of Haemonchus contortus.
    Autorzy:
    Nguyen LT; Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, Australia.; Department of Biochemical Sciences, Charles University, Faculty of Pharmacy, Hradec Králové, Czech Republic.
    Kurz T; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
    Preston S; Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, Australia.; Faculty of Science and Technology, Federation University, Ballarat, VIC, Australia.
    Brueckmann H; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
    Lungerich B; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
    Herath HMPD; Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, Australia.
    Koehler AV; Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, Australia.
    Wang T; Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, Australia.
    Skálová L; Department of Biochemical Sciences, Charles University, Faculty of Pharmacy, Hradec Králové, Czech Republic.
    Jabbar A; Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, Australia.
    Gasser RB; Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, Australia. .
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    Źródło:
    Parasites & vectors [Parasit Vectors] 2019 Apr 30; Vol. 12 (1), pp. 191. Date of Electronic Publication: 2019 Apr 30.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Anthelmintics/*pharmacology
    Haemonchus/*growth & development
    Animals ; Anthelmintics/chemistry ; Drug Evaluation, Preclinical ; Female ; Haemonchus/drug effects ; Inhibitory Concentration 50 ; Larva/drug effects ; Larva/growth & development ; Male ; Phenotype
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Screening of the 'Stasis Box' identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus.
    Autorzy:
    Jiao Y; Faculty of Veterinary and Agricultural Sciences, Melbourne Veterinary School, The University of Melbourne, Parkville, VIC, 3010, Australia.
    Preston S; Faculty of Veterinary and Agricultural Sciences, Melbourne Veterinary School, The University of Melbourne, Parkville, VIC, 3010, Australia.
    Koehler AV; Faculty of Veterinary and Agricultural Sciences, Melbourne Veterinary School, The University of Melbourne, Parkville, VIC, 3010, Australia.
    Stroehlein AJ; Faculty of Veterinary and Agricultural Sciences, Melbourne Veterinary School, The University of Melbourne, Parkville, VIC, 3010, Australia.
    Chang BCH; Faculty of Veterinary and Agricultural Sciences, Melbourne Veterinary School, The University of Melbourne, Parkville, VIC, 3010, Australia.
    Simpson KJ; Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Parkville, VIC, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.
    Cowley KJ; Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Parkville, VIC, Australia.
    Palmer MJ; Medicines for Malaria Venture (MMV), Route de Pré-Bois 20, CH-1215, Geneva, Switzerland.
    Laleu B; Medicines for Malaria Venture (MMV), Route de Pré-Bois 20, CH-1215, Geneva, Switzerland.
    Wells TNC; Medicines for Malaria Venture (MMV), Route de Pré-Bois 20, CH-1215, Geneva, Switzerland.
    Jabbar A; Faculty of Veterinary and Agricultural Sciences, Melbourne Veterinary School, The University of Melbourne, Parkville, VIC, 3010, Australia. .
    Gasser RB; Faculty of Veterinary and Agricultural Sciences, Melbourne Veterinary School, The University of Melbourne, Parkville, VIC, 3010, Australia. .
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    Źródło:
    Parasites & vectors [Parasit Vectors] 2017 Jul 05; Vol. 10 (1), pp. 323. Date of Electronic Publication: 2017 Jul 05.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Antinematodal Agents/*pharmacology
    Haemonchiasis/*drug therapy
    Haemonchus/*drug effects
    Oxazoles/*pharmacology
    Thiazoles/*pharmacology
    Tyrphostins/*pharmacology
    Amino Acid Sequence ; Animals ; Antinematodal Agents/chemistry ; Cell Line ; Dose-Response Relationship, Drug ; Haemonchiasis/parasitology ; Humans ; Larva ; Models, Molecular ; Oxazoles/chemistry ; Protein Kinase Inhibitors/pharmacology ; Sequence Alignment ; Small Molecule Libraries ; Thiazoles/chemistry ; Tyrphostins/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus.
    Autorzy:
    Jiao Y; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.
    Preston S; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.; Faculty of Science and Technology, Federation University, Ballarat, VIC, 3350, Australia.
    Song H; State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China.
    Jabbar A; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.
    Liu Y; State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China.
    Baell J; Medicinal Chemistry, Monash University Institute of Pharmaceutical Sciences (MIPS), Monash University, Parkville, VIC, 3052, Australia.
    Hofmann A; Griffith Institute for Drug Discovery, Griffith University, Don Young Road, Nathan, QLD, 4111, Australia.
    Hutchinson D; Drug Discovery Biology, Monash University Institute of Pharmaceutical Sciences (MIPS), Monash University, Parkville, VIC, 3052, Australia.
    Wang T; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.
    Koehler AV; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.
    Fisher GM; Griffith Institute for Drug Discovery, Griffith University, Don Young Road, Nathan, QLD, 4111, Australia.
    Andrews KT; Griffith Institute for Drug Discovery, Griffith University, Don Young Road, Nathan, QLD, 4111, Australia.
    Laleu B; Medicines for Malaria Venture (MMV), Route de Pré-Bois 20, CH-1215, Geneva, Switzerland.
    Palmer MJ; Medicines for Malaria Venture (MMV), Route de Pré-Bois 20, CH-1215, Geneva, Switzerland.
    Burrows JN; Medicines for Malaria Venture (MMV), Route de Pré-Bois 20, CH-1215, Geneva, Switzerland.
    Wells TNC; Medicines for Malaria Venture (MMV), Route de Pré-Bois 20, CH-1215, Geneva, Switzerland.
    Wang Q; State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China. .
    Gasser RB; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia. .; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, 430070, China. .
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    Źródło:
    Parasites & vectors [Parasit Vectors] 2017 May 31; Vol. 10 (1), pp. 272. Date of Electronic Publication: 2017 May 31.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Anthelmintics/*pharmacology
    Haemonchus/*drug effects
    Pyrazoles/*chemistry
    Pyrazoles/*pharmacology
    Animals ; Biological Assay ; Drug Evaluation, Preclinical ; Haemonchiasis/drug therapy ; Haemonchiasis/mortality ; Haemonchiasis/veterinary ; Haemonchus/pathogenicity ; Larva/drug effects ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondrial Diseases ; Oxygen Consumption/drug effects ; Parasitic Sensitivity Tests ; Quaternary Ammonium Compounds/pharmacology ; Reproducibility of Results ; Ruminants/parasitology ; Toxicity Tests
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus.
    Autorzy:
    Preston S; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.
    Luo J; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430072, China.
    Zhang Y; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.; Medicinal Chemistry, Monash University Institute of Pharmaceutical Sciences (MIPS), Monash University, Parkville, VIC, 3052, Australia.; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, 430070, China.
    Jabbar A; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.
    Crawford S; School of Biosciences, The University of Melbourne, Parkville, VIC, 3010, Australia.
    Baell J; Medicinal Chemistry, Monash University Institute of Pharmaceutical Sciences (MIPS), Monash University, Parkville, VIC, 3052, Australia.
    Hofmann A; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.; Structural Chemistry Program, Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD, 4111, Australia.
    Hu M; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, 430070, China.
    Zhou HB; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430072, China. .
    Gasser RB; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia. .; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430072, China. .
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    Źródło:
    Parasites & vectors [Parasit Vectors] 2016 Jun 16; Vol. 9 (1), pp. 346. Date of Electronic Publication: 2016 Jun 16.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antiparasitic Agents/*pharmacology
    Haemonchus/*drug effects
    Organoselenium Compounds/*pharmacology
    Phenols/*pharmacology
    Receptors, Estrogen/*antagonists & inhibitors
    Sulfur Compounds/*pharmacology
    Thiophenes/*pharmacology
    Aminoacetonitrile/analogs & derivatives ; Aminoacetonitrile/pharmacology ; Animals ; Antiparasitic Agents/chemistry ; Haemonchus/growth & development ; Macrolides/pharmacology ; Molecular Structure ; Organoselenium Compounds/chemistry ; Phenols/chemistry ; Structure-Activity Relationship ; Sulfur Compounds/chemistry ; Thiophenes/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Anthelmintic activity of selected ethno-medicinal plant extracts on parasitic stages of Haemonchus contortus.
    Autorzy:
    Kumarasingha R; Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia.
    Preston S; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.
    Yeo TC; Sarawak Biodiversity Centre (SBC), KM 20 Jalan Borneo Heights, Semengoh, Locked Bag No. 3032, 93990, Kuching, Sarawak, Malaysia.
    Lim DS; Sarawak Biodiversity Centre (SBC), KM 20 Jalan Borneo Heights, Semengoh, Locked Bag No. 3032, 93990, Kuching, Sarawak, Malaysia.
    Tu CL; Sarawak Biodiversity Centre (SBC), KM 20 Jalan Borneo Heights, Semengoh, Locked Bag No. 3032, 93990, Kuching, Sarawak, Malaysia.
    Palombo EA; Department of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Victoria, 3122, Australia.
    Shaw JM; Department of Health and Medical Sciences, Faculty of Health, Arts and Design, Swinburne University of Technology, Victoria, 3122, Australia.
    Gasser RB; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia. .
    Boag PR; Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia. .; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia. .
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    Źródło:
    Parasites & vectors [Parasit Vectors] 2016 Apr 01; Vol. 9, pp. 187. Date of Electronic Publication: 2016 Apr 01.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Anthelmintics/*pharmacology
    Haemonchus/*drug effects
    Plant Extracts/*pharmacology
    Plants, Medicinal/*chemistry
    Animals ; Anthelmintics/isolation & purification ; Haemonchus/growth & development ; Haemonchus/physiology ; Larva/drug effects ; Larva/growth & development ; Larva/physiology ; Locomotion/drug effects ; Plant Extracts/isolation & purification
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The effect of different adjuvants on immune parameters and protection following vaccination of sheep with a larval-specific antigen of the gastrointestinal nematode, Haemonchus contortus.
    Autorzy:
    Piedrafita D; School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia ; The ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Victoria, Australia.
    Preston S
    Kemp J
    de Veer M
    Sherrard J
    Kraska T
    Elhay M
    Meeusen E
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    Źródło:
    PloS one [PLoS One] 2013 Oct 21; Vol. 8 (10), pp. e78357. Date of Electronic Publication: 2013 Oct 21 (Print Publication: 2013).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Adjuvants, Pharmaceutic/*pharmacology
    Antigens, Helminth/*immunology
    Gastrointestinal Diseases/*immunology
    Haemonchus/*immunology
    Larva/*immunology
    Nematoda/*immunology
    Sheep/*immunology
    Adjuvants, Immunologic/pharmacology ; Animals ; Antibodies, Helminth/immunology ; DEAE-Dextran/pharmacology ; Feces/parasitology ; Gastrointestinal Diseases/drug therapy ; Gastrointestinal Diseases/parasitology ; Haemonchiasis/diet therapy ; Haemonchiasis/immunology ; Haemonchiasis/parasitology ; Haemonchus/drug effects ; Larva/drug effects ; Nematoda/drug effects ; Nematode Infections/drug therapy ; Nematode Infections/immunology ; Nematode Infections/parasitology ; Parasite Egg Count/methods ; Sheep/parasitology ; Sheep Diseases/drug therapy ; Sheep Diseases/immunology ; Sheep Diseases/parasitology ; Vaccination/methods ; Vaccines/immunology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-8 z 8

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