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Tytuł :
Financial analysis of large-volume delayed sampling to reduce bacterial contamination of platelets.
Autorzy :
Kacker S; Transfusion Medicine Division, Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Katz LM; Mississippi Valley Regional Blood Center, Davenport, Iowa, USA.
Ness PM; Transfusion Medicine Division, Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Bloch EM; Transfusion Medicine Division, Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Goel R; Transfusion Medicine Division, Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.; Mississippi Valley Regional Blood Center, Davenport, Iowa, USA.
Gehrie EA; Transfusion Medicine Division, Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Lokhandwala PM; Transfusion Medicine Division, Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Tobian AAR; Transfusion Medicine Division, Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
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Źródło :
Transfusion [Transfusion] 2020 May; Vol. 60 (5), pp. 997-1002. Date of Electronic Publication: 2020 Apr 10.
Typ publikacji :
Journal Article
MeSH Terms :
Infection Control*/economics
Infection Control*/methods
Plateletpheresis*/adverse effects
Plateletpheresis*/economics
Plateletpheresis*/methods
Plateletpheresis*/standards
Bacterial Infections/*prevention & control
Drug Contamination/*prevention & control
Platelet Transfusion/*economics
Platelet Transfusion/*statistics & numerical data
Primary Cell Culture/*economics
Bacterial Infections/economics ; Bacterial Infections/epidemiology ; Bacterial Infections/transmission ; Blood Banks/economics ; Blood Banks/standards ; Blood Banks/statistics & numerical data ; Blood Platelets/microbiology ; Blood Safety/economics ; Blood Safety/methods ; Blood Safety/standards ; Blood Specimen Collection/adverse effects ; Blood Specimen Collection/economics ; Blood Specimen Collection/standards ; Blood Specimen Collection/statistics & numerical data ; Costs and Cost Analysis ; Diagnostic Tests, Routine/economics ; Diagnostic Tests, Routine/standards ; Diagnostic Tests, Routine/statistics & numerical data ; Drug Contamination/economics ; Drug Contamination/statistics & numerical data ; Feasibility Studies ; Humans ; Implementation Science ; Microbiological Techniques ; Primary Cell Culture/methods ; Primary Cell Culture/standards ; Primary Cell Culture/statistics & numerical data ; Risk Reduction Behavior ; Sample Size ; Time Factors ; Time-to-Treatment/economics ; Time-to-Treatment/statistics & numerical data ; Transfusion Reaction/economics ; Transfusion Reaction/epidemiology ; Transfusion Reaction/microbiology ; Transfusion Reaction/prevention & control
Czasopismo naukowe
Tytuł :
Bacterial contamination rate of platelet components by primary culture: a systematic review and meta-analysis.
Autorzy :
White SK; Department of Pathology, University of Utah, Salt Lake City, Utah.
Schmidt RL; Department of Pathology, University of Utah, Salt Lake City, Utah.; ARUP Laboratories, Salt Lake City, Utah.
Walker BS; ARUP Laboratories, Salt Lake City, Utah.
Metcalf RA; Department of Pathology, University of Utah, Salt Lake City, Utah.; ARUP Laboratories, Salt Lake City, Utah.
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Źródło :
Transfusion [Transfusion] 2020 May; Vol. 60 (5), pp. 986-996. Date of Electronic Publication: 2020 Mar 17.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Bacterial Infections/*blood
Blood Component Removal/*statistics & numerical data
Blood Platelets/*microbiology
Drug Contamination/*statistics & numerical data
Platelet Transfusion/*statistics & numerical data
Primary Cell Culture/*statistics & numerical data
Bacterial Infections/epidemiology ; Bacterial Infections/transmission ; Bacteriological Techniques ; Blood Component Removal/adverse effects ; Blood Component Transfusion/adverse effects ; Blood Component Transfusion/statistics & numerical data ; Blood Platelets/cytology ; Cells, Cultured ; Humans ; Platelet Transfusion/adverse effects ; Platelet-Rich Plasma/microbiology ; Primary Cell Culture/methods ; Primary Cell Culture/standards ; Transfusion Reaction/epidemiology ; Transfusion Reaction/microbiology
Czasopismo naukowe
Tytuł :
Bacterial contamination and septic transfusion reaction rates associated with platelet components before and after introduction of primary culture: experience at a US Academic Medical Center 1991 through 2017.
Autorzy :
Kundrapu S; Department of Pathology and Medicine, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Srivastava S; Department of Pathology and Medicine, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Good CE; Department of Pathology and Medicine, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Lazarus HM; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Maitta RW; Department of Pathology and Medicine, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Jacobs MR; Department of Pathology and Medicine, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
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Źródło :
Transfusion [Transfusion] 2020 May; Vol. 60 (5), pp. 974-985. Date of Electronic Publication: 2020 May 01.
Typ publikacji :
Historical Article; Journal Article
MeSH Terms :
Platelet Transfusion*/adverse effects
Platelet Transfusion*/history
Platelet Transfusion*/statistics & numerical data
Primary Cell Culture*/history
Primary Cell Culture*/standards
Primary Cell Culture*/statistics & numerical data
Bacterial Infections/*epidemiology
Drug Contamination/*statistics & numerical data
Sepsis/*epidemiology
Transfusion Reaction/*epidemiology
Academic Medical Centers ; Adult ; Bacterial Infections/blood ; Bacterial Infections/transmission ; Blood Component Removal/adverse effects ; Blood Component Removal/history ; Blood Component Removal/standards ; Blood Component Removal/statistics & numerical data ; Blood Platelets/cytology ; Blood Platelets/microbiology ; Blood Safety/adverse effects ; Blood Safety/history ; Blood Safety/statistics & numerical data ; Blood Transfusion/history ; Blood Transfusion/statistics & numerical data ; Cells, Cultured ; Child ; History, 20th Century ; History, 21st Century ; Humans ; Incidence ; Retrospective Studies ; Sepsis/blood ; Sepsis/etiology ; Transfusion Reaction/microbiology ; United States/epidemiology
Czasopismo naukowe
Tytuł :
Group O plasma as a media supplement for CAR-T cells and other adoptive T-cell therapies.
Autorzy :
Nelson RC; Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland.; Center for Cellular Engineering, National Institutes of Health Clinical Center, Bethesda, Maryland.; Department of Pathology, Montefiore Medical Center & Albert Einstein College of Medicine, Bronx, New York.
Fellowes V; Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland.; Center for Cellular Engineering, National Institutes of Health Clinical Center, Bethesda, Maryland.
Jin P; Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland.; Center for Cellular Engineering, National Institutes of Health Clinical Center, Bethesda, Maryland.
Liu H; Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland.; Center for Cellular Engineering, National Institutes of Health Clinical Center, Bethesda, Maryland.
Highfill SL; Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland.; Center for Cellular Engineering, National Institutes of Health Clinical Center, Bethesda, Maryland.
Ren J; Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland.; Center for Cellular Engineering, National Institutes of Health Clinical Center, Bethesda, Maryland.
Szymanski J; Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland.; Center for Cellular Engineering, National Institutes of Health Clinical Center, Bethesda, Maryland.; Department of Pathology, Montefiore Medical Center & Albert Einstein College of Medicine, Bronx, New York.
Flegel WA; Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland.
Stroncek DF; Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland.; Center for Cellular Engineering, National Institutes of Health Clinical Center, Bethesda, Maryland.
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Źródło :
Transfusion [Transfusion] 2020 May; Vol. 60 (5), pp. 1004-1014. Date of Electronic Publication: 2020 Mar 13.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Immunotherapy, Adoptive*/methods
ABO Blood-Group System/*blood
Culture Media/*chemistry
Plasma/*physiology
Primary Cell Culture/*methods
T-Lymphocytes/*cytology
Cells, Cultured ; Flow Cytometry ; HLA-A Antigens/blood ; HLA-A Antigens/immunology ; Humans ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/transplantation ; Lymphocyte Activation ; Plasma/chemistry ; Primary Cell Culture/standards ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/metabolism ; T-Lymphocytes/metabolism ; T-Lymphocytes/transplantation ; Tissue Donors
Czasopismo naukowe
Tytuł :
Ballistic Labeling of Pyramidal Neurons in Brain Slices and in Primary Cell Culture.
Autorzy :
Li H; Program in Behavioral Neuroscience, Department of Psychology, University of South Carolina.
McLaurin KA; Program in Behavioral Neuroscience, Department of Psychology, University of South Carolina.
Mactutus CF; Program in Behavioral Neuroscience, Department of Psychology, University of South Carolina.
Booze RM; Program in Behavioral Neuroscience, Department of Psychology, University of South Carolina; .
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2020 Apr 02 (158). Date of Electronic Publication: 2020 Apr 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Video-Audio Media
MeSH Terms :
Primary Cell Culture*
Staining and Labeling*
Brain/*cytology
Pyramidal Cells/*metabolism
Animals ; Dendritic Spines/metabolism ; Pyramidal Cells/cytology ; Rats
Czasopismo naukowe
Tytuł :
α-Irradiation setup for primary human cell cultures.
Autorzy :
Maier A; GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.
Wiedemann J; GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.
Adrian JA; GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.; Physics Department, Technical University, Darmstadt, Germany.
Dornhecker M; GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.; Biophysics Department, Goethe University, Frankfurt, Germany.
Zipf A; GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.; Physics Department, Technical University, Darmstadt, Germany.
Kraft-Weyrather W; GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.
Kraft G; GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.
Richter S; Fraunhofer-Institut für Mikrostruktur von Werkstoffen und Systemen IMWS, Halle, Germany.
Teuscher N; Fraunhofer-Institut für Mikrostruktur von Werkstoffen und Systemen IMWS, Halle, Germany.
Fournier C; GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.
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Źródło :
International journal of radiation biology [Int J Radiat Biol] 2020 Feb; Vol. 96 (2), pp. 206-213. Date of Electronic Publication: 2019 Nov 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alpha Particles*
Americium*
Linear Energy Transfer*
Primary Cell Culture*
Animals ; CHO Cells ; Cell Line ; Collagen/chemistry ; Cricetinae ; Cricetulus ; Dose-Response Relationship, Radiation ; Histones/metabolism ; Humans ; Keratinocytes/cytology ; Oxygen/metabolism ; Polyethylene Terephthalates ; Radiometry ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Well-Differentiated Primary Mammalian Airway Epithelial Cell Cultures.
Autorzy :
Gultom M; Institute of Virology and Immunology, Bern & Mittelhäusern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.; Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Laloli L; Institute of Virology and Immunology, Bern & Mittelhäusern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.; Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Dijkman R; Institute of Virology and Immunology, Bern & Mittelhäusern, Switzerland. .; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland. .; Institute for Infectious Diseases, University of Bern, Bern, Switzerland. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2020; Vol. 2203, pp. 119-134.
Typ publikacji :
Journal Article
MeSH Terms :
Bronchi/*cytology
Coronavirus/*physiology
Epithelial Cells/*virology
Primary Cell Culture/*methods
Trachea/*cytology
Animals ; Cats ; Cattle ; Cell Differentiation ; Epithelial Cells/cytology ; Fluorescent Antibody Technique ; Humans ; Immunohistochemistry/methods ; Primary Cell Culture/instrumentation ; Swine ; Viral Tropism
Czasopismo naukowe
Tytuł :
A growth model of neuroendocrine tumor surrogates and the efficacy of a novel somatostatin-receptor-guided antibody-drug conjugate: Perspectives on clinical response?
Autorzy :
Herring B; University of Alabama at Birmingham School of Medicine, AL.
Whitt J; Department of Surgery, University of Alabama at Birmingham School of Medicine, AL.
Aweda T; Department of Radiology, University of Alabama at Birmingham School of Medicine, AL.
Ou J; Department of Biomedical Engineering, University of Alabama at Birmingham School of Medicine, AL.
Guenter R; University of Alabama at Birmingham School of Medicine, AL.
Lapi S; Department of Radiology, University of Alabama at Birmingham School of Medicine, AL.
Berry J; Department of Biomedical Engineering, University of Alabama at Birmingham School of Medicine, AL.
Chen H; Department of Surgery, University of Alabama at Birmingham School of Medicine, AL.
Liu X; Department of Biomedical Engineering, University of Alabama at Birmingham School of Medicine, AL.
Rose JB; Department of Surgery, University of Alabama at Birmingham School of Medicine, AL.
Jaskula-Sztul R; Department of Surgery, University of Alabama at Birmingham School of Medicine, AL. Electronic address: .
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Źródło :
Surgery [Surgery] 2020 Jan; Vol. 167 (1), pp. 197-203. Date of Electronic Publication: 2019 Sep 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
Bioreactors*
Drug Screening Assays, Antitumor/*instrumentation
Immunoconjugates/*pharmacology
Neuroendocrine Tumors/*drug therapy
Pancreatic Neoplasms/*drug therapy
Primary Cell Culture/*instrumentation
Animals ; Antineoplastic Agents, Immunological/pharmacology ; Antineoplastic Agents, Immunological/therapeutic use ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor/methods ; Humans ; Immunoconjugates/therapeutic use ; Male ; Mice ; Molecular Targeted Therapy/methods ; Neuroendocrine Tumors/pathology ; Oligopeptides/pharmacology ; Oligopeptides/therapeutic use ; Pancreatic Neoplasms/pathology ; Primary Cell Culture/methods ; Receptors, Somatostatin/antagonists & inhibitors ; Reproducibility of Results ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Effect of total flavonoids of Rhizoma Drynariae in thiram induced cytotoxicity of chondrocyte via BMP-2/Runx2 and IHH/PTHrP expressions.
Autorzy :
Yao W; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, PR China.
Zhang H; South China Agricultural University College of Veterinary Medicine Guangzhou, 510000, PR China.
Fakhar-E-Alam Kulyar M; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, PR China.
Ding Y; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, PR China.
Waqas M; Faculty of Veterinary & Animal Sciences, University of the Poonch, Rawalakot, District Poonch, 12350, Azad Jammu & Kashmir, Pakistan.
Mehmood K; Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, 63100, Pakistan.
Iqbal M; Department of Pathology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, 63100, Pakistan.
Du H; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, PR China.
Jiang X; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, PR China.
Li J; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, PR China; College of Animals Husbandry and Veterinary Medicine, Tibet Agricultural and Animal Husbandry University, Linzhi, Tibet, 860000, PR China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Dec 15; Vol. 206, pp. 111194. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Morphogenetic Protein 2/*genetics
Chondrocytes/*drug effects
Flavonoids/*pharmacology
Gene Expression/*drug effects
Polypodiaceae/*chemistry
Thiram/*toxicity
Animals ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Chickens ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Core Binding Factor Alpha 1 Subunit/genetics ; Flavonoids/isolation & purification ; Growth Plate/cytology ; Growth Plate/drug effects ; Hedgehog Proteins/genetics ; Parathyroid Hormone-Related Protein/genetics ; Primary Cell Culture ; Rhizome ; Up-Regulation
Czasopismo naukowe
Tytuł :
Development and application of species-specific cell-based bioassays to assess toxicity in green sea turtles.
Autorzy :
Finlayson KA; Australian Rivers Institute, Griffith University, Australia. Electronic address: .
Madden Hof CA; World Wildlife Fund for Nature, Australia.
van de Merwe JP; Australian Rivers Institute, Griffith University, Australia.
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Źródło :
The Science of the total environment [Sci Total Environ] 2020 Dec 10; Vol. 747, pp. 142095. Date of Electronic Publication: 2020 Sep 01.
Typ publikacji :
Journal Article
MeSH Terms :
Turtles*
Water Pollutants, Chemical*/analysis
Water Pollutants, Chemical*/toxicity
Animals ; Biological Assay ; Primary Cell Culture ; Queensland
Czasopismo naukowe
Tytuł :
Maternal exposure to Di-n-butyl phthalate (DBP) aggravate gestational diabetes mellitus via FoxM1 suppression by pSTAT1 signalling.
Autorzy :
Chen M; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Zhao S; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Guo WH; Pathology Center, Shanghai General Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Zhu YP; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Pan L; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Xie ZW; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Sun WL; Department of Geriatrics, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China. Electronic address: .
Jiang JT; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Dec 01; Vol. 205, pp. 111154. Date of Electronic Publication: 2020 Aug 15.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Experimental/*chemically induced
Diabetes, Gestational/*chemically induced
Dibutyl Phthalate/*toxicity
Endocrine Disruptors/*toxicity
Forkhead Box Protein M1/*metabolism
Maternal Exposure/*adverse effects
STAT1 Transcription Factor/*metabolism
Animals ; Cells, Cultured ; Diabetes Mellitus, Experimental/metabolism ; Diabetes, Gestational/metabolism ; Female ; Forkhead Box Protein M1/genetics ; Gene Expression/drug effects ; Humans ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Male ; Phosphorylation ; Pregnancy ; Primary Cell Culture ; Rats ; Rats, Sprague-Dawley ; STAT1 Transcription Factor/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Integration of proteomics, lipidomics, and metabolomics reveals novel metabolic mechanisms underlying N, N-dimethylformamide induced hepatotoxicity.
Autorzy :
Xu L; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Zhao Q; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Luo J; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Ma W; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Jin Y; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Li C; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Hou Y; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Feng M; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Wang Y; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Chen J; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Zhao J; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China.
Zheng Y; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China. Electronic address: .
Yu D; Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Dec 01; Vol. 205, pp. 111166. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article
MeSH Terms :
Chemical and Drug Induced Liver Injury/*metabolism
Dimethylformamide/*toxicity
Environmental Pollutants/*toxicity
Hepatocytes/*drug effects
Lipid Metabolism/*drug effects
Metabolome/*drug effects
Proteome/*metabolism
Animals ; Cell Survival/drug effects ; Cells, Cultured ; Endoplasmic Reticulum Stress/drug effects ; Glutathione/metabolism ; Hepatocytes/metabolism ; Humans ; Lipidomics ; Metabolomics ; Primary Cell Culture ; Proteomics ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Toxicity Tests/methods
Czasopismo naukowe
Tytuł :
Insulin negatively regulates dedifferentiation of mouse adipocytes in vitro.
Autorzy :
Zang L; Shandong Provincial Key Laboratory of Animal Resistant Biology, College of Life Sciences, Shandong Normal University, Jinan, China.
Kothan S; Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Yang Y; Shandong Provincial Key Laboratory of Animal Resistant Biology, College of Life Sciences, Shandong Normal University, Jinan, China.
Zeng X; Shandong Provincial Key Laboratory of Animal Resistant Biology, College of Life Sciences, Shandong Normal University, Jinan, China.
Ye L; Shandong Provincial Key Laboratory of Animal Resistant Biology, College of Life Sciences, Shandong Normal University, Jinan, China.
Pan J; Shandong Provincial Key Laboratory of Animal Resistant Biology, College of Life Sciences, Shandong Normal University, Jinan, China.; Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
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Źródło :
Adipocyte [Adipocyte] 2020 Dec; Vol. 9 (1), pp. 24-34.
Typ publikacji :
Journal Article
MeSH Terms :
Adipocytes, White/*cytology
Insulin/*pharmacology
Leptin/*genetics
Receptors, Leptin/*genetics
Tumor Necrosis Factor-alpha/*genetics
Adipocytes, White/metabolism ; Animals ; Biomarkers/analysis ; Cell Dedifferentiation ; Cells, Cultured ; Culture Media/chemistry ; Gene Expression Regulation ; Gene Knockout Techniques ; Mice ; Point Mutation ; Primary Cell Culture ; Receptors, Leptin/metabolism
Czasopismo naukowe
Tytuł :
RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA.
Autorzy :
Zhang ZD; Department of Virology, College of Life Sciences, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China.; Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China.; Department of Immunology, Medical Research Institute and Frontier Science Center for Immunology and Metabolism, Wuhan University, 430072, Wuhan, China.
Xiong TC; Department of Virology, College of Life Sciences, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China.; Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China.; Department of Immunology, Medical Research Institute and Frontier Science Center for Immunology and Metabolism, Wuhan University, 430072, Wuhan, China.
Yao SQ; Department of Virology, College of Life Sciences, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China.; Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China.; Department of Immunology, Medical Research Institute and Frontier Science Center for Immunology and Metabolism, Wuhan University, 430072, Wuhan, China.
Wei MC; Department of Virology, College of Life Sciences, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China.; Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China.; Department of Immunology, Medical Research Institute and Frontier Science Center for Immunology and Metabolism, Wuhan University, 430072, Wuhan, China.
Chen M; Department of Blood Transfusion, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China.
Lin D; Cancer Center, Renmin Hospital of Wuhan University, 430060, Wuhan, China.
Zhong B; Department of Virology, College of Life Sciences, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China. .; Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China. .; Department of Immunology, Medical Research Institute and Frontier Science Center for Immunology and Metabolism, Wuhan University, 430072, Wuhan, China. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 02; Vol. 11 (1), pp. 5536. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Adaptor Proteins, Signal Transducing/*metabolism
Cardiovirus Infections/*immunology
Herpes Simplex/*immunology
Membrane Proteins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Animals ; Cardiovirus Infections/pathology ; Cardiovirus Infections/virology ; Disease Models, Animal ; Encephalomyocarditis virus/immunology ; Female ; HEK293 Cells ; Herpes Simplex/pathology ; Herpes Simplex/virology ; Herpesvirus 1, Human/immunology ; Host-Pathogen Interactions/immunology ; Humans ; Lysine/metabolism ; Macrophages/immunology ; Macrophages/virology ; Male ; Mice ; Mice, Knockout ; Primary Cell Culture ; Protein Aggregates/immunology ; RNA, Small Interfering/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/physiology ; Ubiquitination/immunology
Czasopismo naukowe
Tytuł :
Shinorine ameliorates chromium induced toxicity in zebrafish hepatocytes through the facultative activation of Nrf2-Keap1-ARE pathway.
Autorzy :
Shaw P; Department of Zoology, Visva-Bharati, Santiniketan 731235, West Bengal, India.
Sen A; Department of Botany, Visva-Bharati, Santiniketan 731235, West Bengal, India.
Mondal P; Department of Zoology, Visva-Bharati, Santiniketan 731235, West Bengal, India.
Dey Bhowmik A; Department of Zoology, Visva-Bharati, Santiniketan 731235, West Bengal, India.
Rath J; Department of Botany, Visva-Bharati, Santiniketan 731235, West Bengal, India.
Chattopadhyay A; Department of Zoology, Visva-Bharati, Santiniketan 731235, West Bengal, India. Electronic address: .
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Źródło :
Aquatic toxicology (Amsterdam, Netherlands) [Aquat Toxicol] 2020 Nov; Vol. 228, pp. 105622. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article
MeSH Terms :
Chromium/*toxicity
Cyclohexylamines/*pharmacology
Glycine/*analogs & derivatives
Hepatocytes/*drug effects
Kelch-Like ECH-Associated Protein 1/*antagonists & inhibitors
NF-E2-Related Factor 2/*metabolism
Water Pollutants, Chemical/*toxicity
Zebrafish/*metabolism
Animals ; Cell Survival/drug effects ; Cells, Cultured ; Cyanobacteria/metabolism ; Cyclohexylamines/isolation & purification ; Glycine/isolation & purification ; Glycine/pharmacology ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Kelch-Like ECH-Associated Protein 1/metabolism ; Molecular Docking Simulation ; Oxidative Stress/drug effects ; Primary Cell Culture ; Signal Transduction
Czasopismo naukowe
Tytuł :
Survey of ex vivo drug combination effects in chronic lymphocytic leukemia reveals synergistic drug effects and genetic dependencies.
Autorzy :
Lukas M; Department of Molecular Therapy in Haematology and Oncology, DKFZ & NCT Heidelberg, Heidelberg, Germany.; Department of Internal Medicine II, Klinikum Rechts der Isar, TU München, München, Germany.
Velten B; Genome Biology Unit, EMBL, Heidelberg, Germany.
Sellner L; Department of Molecular Therapy in Haematology and Oncology, DKFZ & NCT Heidelberg, Heidelberg, Germany.; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.
Tomska K; Department of Molecular Therapy in Haematology and Oncology, DKFZ & NCT Heidelberg, Heidelberg, Germany.; Department of Pediatrics, University Hospital Heidelberg, Heidelberg, Germany.
Hüellein J; Department of Molecular Therapy in Haematology and Oncology, DKFZ & NCT Heidelberg, Heidelberg, Germany.; Genome Biology Unit, EMBL, Heidelberg, Germany.
Walther T; Department of Molecular Therapy in Haematology and Oncology, DKFZ & NCT Heidelberg, Heidelberg, Germany.
Wagner L; Department of Molecular Therapy in Haematology and Oncology, DKFZ & NCT Heidelberg, Heidelberg, Germany.
Muley C; Department of Molecular Therapy in Haematology and Oncology, DKFZ & NCT Heidelberg, Heidelberg, Germany.
Wu B; Department of Molecular Therapy in Haematology and Oncology, DKFZ & NCT Heidelberg, Heidelberg, Germany.
Oleś M; Genome Biology Unit, EMBL, Heidelberg, Germany.
Dietrich S; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.
Jethwa A; Department of Molecular Therapy in Haematology and Oncology, DKFZ & NCT Heidelberg, Heidelberg, Germany.
Bohnenberger H; Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany.
Lu J; Genome Biology Unit, EMBL, Heidelberg, Germany.
Huber W; Genome Biology Unit, EMBL, Heidelberg, Germany. .
Zenz T; Department of Medical Oncology and Haematology, University Hospital Zürich and University of Zürich, Zürich, Switzerland. .
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Źródło :
Leukemia [Leukemia] 2020 Nov; Vol. 34 (11), pp. 2934-2950. Date of Electronic Publication: 2020 May 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Evaluation, Preclinical*/methods
Drug Evaluation, Preclinical*/standards
Antineoplastic Agents/*pharmacology
Drug Resistance, Neoplasm/*genetics
Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Drug Synergism ; High-Throughput Nucleotide Sequencing/methods ; High-Throughput Nucleotide Sequencing/standards ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Primary Cell Culture ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Receptors, Antigen, B-Cell/antagonists & inhibitors ; Receptors, Antigen, B-Cell/genetics ; Receptors, Antigen, B-Cell/metabolism ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Simvastatin ameliorates altered mechanotransduction in uterine leiomyoma cells.
Autorzy :
Afrin S; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD.
Islam MS; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD.
Patzkowsky K; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD.
Malik M; Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, MD.
Catherino WH; Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, MD.
Segars JH; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD.
Borahay MA; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: .
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Źródło :
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2020 Nov; Vol. 223 (5), pp. 733.e1-733.e14. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology
Leiomyoma/*genetics
Mechanotransduction, Cellular/*drug effects
Simvastatin/*pharmacology
Uterine Neoplasms/*genetics
A Kinase Anchor Proteins/drug effects ; A Kinase Anchor Proteins/genetics ; A Kinase Anchor Proteins/metabolism ; Collagen Type I/drug effects ; Collagen Type I/genetics ; Collagen Type I/metabolism ; Cyclin D1/drug effects ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Extracellular Matrix/drug effects ; Extracellular Matrix/genetics ; Extracellular Matrix/metabolism ; Female ; Focal Adhesion Protein-Tyrosine Kinases/drug effects ; Focal Adhesion Protein-Tyrosine Kinases/genetics ; Focal Adhesion Protein-Tyrosine Kinases/metabolism ; Humans ; Integrin beta1/drug effects ; Integrin beta1/genetics ; Integrin beta1/metabolism ; Leiomyoma/metabolism ; Mechanotransduction, Cellular/genetics ; Minor Histocompatibility Antigens/drug effects ; Minor Histocompatibility Antigens/genetics ; Minor Histocompatibility Antigens/metabolism ; Myosin-Light-Chain Kinase/drug effects ; Myosin-Light-Chain Kinase/genetics ; Myosin-Light-Chain Kinase/metabolism ; Phosphorylation ; Primary Cell Culture ; Proto-Oncogene Proteins/drug effects ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; RNA, Messenger/drug effects ; RNA, Messenger/metabolism ; Uterine Neoplasms/metabolism ; rho-Associated Kinases/drug effects ; rho-Associated Kinases/genetics ; rho-Associated Kinases/metabolism ; rhoA GTP-Binding Protein/drug effects ; rhoA GTP-Binding Protein/genetics ; rhoA GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Maduramicin triggers methuosis-like cell death in primary chicken myocardial cells.
Autorzy :
Gao X; Joint International Research Laboratory of Animal Health and Food Safety, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China.
Ruan X; Joint International Research Laboratory of Animal Health and Food Safety, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China; Laboratory of Veterinary Pharmacology and Toxicology, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, PR China.
Ji H; Joint International Research Laboratory of Animal Health and Food Safety, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China.
Peng L; Joint International Research Laboratory of Animal Health and Food Safety, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China.
Qiu Y; Joint International Research Laboratory of Animal Health and Food Safety, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China.
Yang D; Joint International Research Laboratory of Animal Health and Food Safety, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China.
Song X; Joint International Research Laboratory of Animal Health and Food Safety, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China.
Ji C; Joint International Research Laboratory of Animal Health and Food Safety, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China.
Guo D; Joint International Research Laboratory of Animal Health and Food Safety, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China. Electronic address: .
Jiang S; Joint International Research Laboratory of Animal Health and Food Safety, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Oct 15; Vol. 333, pp. 105-114. Date of Electronic Publication: 2020 Jul 28.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Death/*drug effects
Fibroblasts/*drug effects
Lactones/*toxicity
Myocytes, Cardiac/*drug effects
Veterinary Drugs/*toxicity
Adenosine Triphosphate/metabolism ; Animals ; Apoptosis/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Chick Embryo ; Chickens ; Cytoplasm ; DNA Fragmentation/drug effects ; Fibroblasts/metabolism ; Fibroblasts/ultrastructure ; Microscopy, Electron, Transmission ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/ultrastructure ; Primary Cell Culture ; Time-Lapse Imaging ; Vacuoles/drug effects ; Vacuoles/ultrastructure
Czasopismo naukowe
Tytuł :
The expression and role of glycolysis-associated molecules in infantile hemangioma.
Autorzy :
Chen J; Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; Department of Oral and Maxillofacial Surgery, Qilu Hospital, Cheeloo College of Medicine, Institute of Stomatology, Shandong University, Jinan, Shandong 250012, China.
Wu D; Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; Department of Oral and Maxillofacial Surgery, Qilu Hospital, Cheeloo College of Medicine, Institute of Stomatology, Shandong University, Jinan, Shandong 250012, China.
Dong Z; Department of Oral and Maxillofacial Surgery, Qilu Hospital, Cheeloo College of Medicine, Institute of Stomatology, Shandong University, Jinan, Shandong 250012, China.
Chen A; Department of Oral and Maxillofacial Surgery, Qilu Hospital, Cheeloo College of Medicine, Institute of Stomatology, Shandong University, Jinan, Shandong 250012, China.
Liu S; Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; Department of Oral and Maxillofacial Surgery, Qilu Hospital, Cheeloo College of Medicine, Institute of Stomatology, Shandong University, Jinan, Shandong 250012, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Oct 15; Vol. 259, pp. 118215. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Glycolysis/*physiology
Hemangioma/*metabolism
Apoptosis/drug effects ; Cell Proliferation/drug effects ; China ; Female ; Glucose Transporter Type 1/genetics ; Glucose Transporter Type 1/metabolism ; Glycolysis/genetics ; Hemangioma/physiopathology ; Hexokinase/genetics ; Hexokinase/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Hypoxia ; Infant ; Infant, Newborn ; L-Lactate Dehydrogenase/genetics ; L-Lactate Dehydrogenase/metabolism ; Male ; Phosphofructokinase-2/genetics ; Phosphofructokinase-2/metabolism ; Primary Cell Culture ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
Selenium-independent antioxidant and anti-inflammatory effects of thioredoxin reductase inhibition in alveolar macrophages.
Autorzy :
Staples S; Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Wall SB; Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Li R; Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Tipple TE; Center for Pregnancy and Newborn Research, Section of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Oklahoma College of Medicine, Oklahoma City, OK, USA. Electronic address: .
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2020 Oct 15; Vol. 259, pp. 118285. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article
MeSH Terms :
Auranofin/*pharmacology
Macrophages, Alveolar/*metabolism
Thioredoxin Reductase 1/*metabolism
Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Auranofin/metabolism ; Bronchopulmonary Dysplasia/metabolism ; Bronchopulmonary Dysplasia/physiopathology ; Glutathione/metabolism ; Interleukin-1beta/drug effects ; Interleukin-1beta/metabolism ; Lipopolysaccharides/pharmacology ; Lung/metabolism ; Macrophages/metabolism ; Macrophages, Alveolar/physiology ; Mice ; Primary Cell Culture ; Selenium/metabolism ; Selenium/pharmacology ; Thioredoxin Reductase 1/antagonists & inhibitors ; Thioredoxin-Disulfide Reductase/antagonists & inhibitors ; Thioredoxin-Disulfide Reductase/metabolism
Czasopismo naukowe

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