Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Prime, Tracy A."" wg kryterium: Autor


Tytuł :
Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart.
Autorzy :
Park M; Department of Medicine, University of Cambridge, Cambridge, UK.
Nishimura T; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Takeda Pharmaceutical Ltd, Tokyo, Japan.
Baeza-Garza CD; WestCHEM School of Chemistry, University of Glasgow, Glasgow, UK.
Caldwell ST; WestCHEM School of Chemistry, University of Glasgow, Glasgow, UK.
Pun PBL; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Young T; Department of Medicine, University of Cambridge, Cambridge, UK.
Sauchanka O; Department of Medicine, University of Cambridge, Cambridge, UK.
Logan A; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Forkink M; Department of Medicine, University of Cambridge, Cambridge, UK.
Gruszczyk AV; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Prime TA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Arndt S; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Naudi A; Department Of Experimental Medicine, University of Lleida, Lleida Institute for Biomedical Research, Lleida, Spain.
Pamplona R; Department Of Experimental Medicine, University of Lleida, Lleida Institute for Biomedical Research, Lleida, Spain.
Coughlan MT; Department of Diabetes, Monash University, Melbourne, Australia.
Tate M; Department of Diabetes, Monash University, Melbourne, Australia.; Baker Heart and Diabetes Institute, Melbourne, Australia.
Ritchie RH; Department of Diabetes, Monash University, Melbourne, Australia.; Baker Heart and Diabetes Institute, Melbourne, Australia.
Caicci F; Department of Biology, University of Padova, Padua, Italy.
Kaludercic N; Neuroscience Institute, National Research Council of Italy (CNR), Pisa, Italy.
Di Lisa F; Department of Biomedical Sciences, University of Padova, Padua, Italy.
Smith RAJ; Department of Chemistry, University of Otago, Otago, New Zealand.
Hartley RC; WestCHEM School of Chemistry, University of Glasgow, Glasgow, UK.
Murphy MP; Department of Medicine, University of Cambridge, Cambridge, UK.; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Krieg T; Department of Medicine, University of Cambridge, Cambridge, UK. .
Pokaż więcej
Źródło :
Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2020 Dec; Vol. 34 (6), pp. 823-834. Date of Electronic Publication: 2020 Sep 26.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Enhancing the Mitochondrial Uptake of Phosphonium Cations by Carboxylic Acid Incorporation.
Autorzy :
Pala L; School of Chemistry, University of Glasgow, Glasgow, United Kingdom.
Senn HM; School of Chemistry, University of Glasgow, Glasgow, United Kingdom.
Caldwell ST; School of Chemistry, University of Glasgow, Glasgow, United Kingdom.
Prime TA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, United Kingdom.
Warrington S; School of Chemistry, University of Glasgow, Glasgow, United Kingdom.
Bright TP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, United Kingdom.
Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, United Kingdom.
Wilson C; School of Chemistry, University of Glasgow, Glasgow, United Kingdom.
Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Hartley RC; School of Chemistry, University of Glasgow, Glasgow, United Kingdom.
Pokaż więcej
Źródło :
Frontiers in chemistry [Front Chem] 2020 Sep 09; Vol. 8, pp. 783. Date of Electronic Publication: 2020 Sep 09 (Print Publication: 2020).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo.
Autorzy :
Burger N; MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.
Logan A; MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.
Prime TA; MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.
Mottahedin A; MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK; Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Caldwell ST; School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK.
Krieg T; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Hartley RC; School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK.
James AM; MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.
Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK. Electronic address: .
Pokaż więcej
Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2020 Feb 01; Vol. 147, pp. 37-47. Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo.
Autorzy :
Booty LM; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Gawel JM; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
Cvetko F; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Caldwell ST; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
Hall AR; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Mulvey JF; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.
James AM; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Hinchy EC; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Prime TA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Arndt S; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Beninca C; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Bright TP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Clatworthy MR; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.
Ferdinand JR; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.
Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Logan A; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Prudent J; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Krieg T; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.
Hartley RC; School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK. Electronic address: .
Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address: .
Pokaż więcej
Źródło :
Cell chemical biology [Cell Chem Biol] 2019 Mar 21; Vol. 26 (3), pp. 449-461.e8. Date of Electronic Publication: 2019 Jan 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitochondria/*metabolism
Sulfhydryl Compounds/*chemistry
Animals ; Chromatography, High Pressure Liquid ; Dinitrochlorobenzene/analysis ; Dinitrochlorobenzene/chemistry ; Dinitrochlorobenzene/metabolism ; Dinitrochlorobenzene/pharmacology ; Glutathione/chemistry ; Glutathione/metabolism ; Glutathione Transferase/metabolism ; Hep G2 Cells ; Humans ; Liver/chemistry ; Liver/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Mice ; Oxidation-Reduction ; Reactive Oxygen Species/chemistry ; Reactive Oxygen Species/metabolism ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/isolation & purification ; Tandem Mass Spectrometry ; Thioredoxins/antagonists & inhibitors ; Thioredoxins/genetics ; Thioredoxins/metabolism
Czasopismo naukowe
Tytuł :
Control of mitochondrial superoxide production by reverse electron transport at complex I.
Autorzy :
Robb EL; From the Medical Research Council Mitochondrial Biology Unit, Hills Road, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Hall AR; From the Medical Research Council Mitochondrial Biology Unit, Hills Road, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Prime TA; From the Medical Research Council Mitochondrial Biology Unit, Hills Road, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Eaton S; the UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, United Kingdom.
Szibor M; the Faculty of Medicine and Life Sciences, University of Tampere, Tampere FI-33014, Finland, and.; the Max-Planck-Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany.
Viscomi C; From the Medical Research Council Mitochondrial Biology Unit, Hills Road, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
James AM; From the Medical Research Council Mitochondrial Biology Unit, Hills Road, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Murphy MP; From the Medical Research Council Mitochondrial Biology Unit, Hills Road, University of Cambridge, Cambridge CB2 0XY, United Kingdom, .
Pokaż więcej
Źródło :
The Journal of biological chemistry [J Biol Chem] 2018 Jun 22; Vol. 293 (25), pp. 9869-9879. Date of Electronic Publication: 2018 May 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Electron Transport Complex I/*metabolism
Hydrogen Peroxide/*metabolism
Mitochondria, Heart/*metabolism
Superoxides/*metabolism
Ubiquinone/*metabolism
Animals ; Electron Transport ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Oxidative Phosphorylation ; Rats ; Rats, Wistar ; Signal Transduction
Czasopismo naukowe
Tytuł :
MitoNeoD: A Mitochondria-Targeted Superoxide Probe.
Autorzy :
Shchepinova MM; WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
Cairns AG; WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
Prime TA; MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.
Logan A; MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.
James AM; MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.
Hall AR; MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.
Vidoni S; MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.
Arndt S; MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.
Caldwell ST; WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.
Pell VR; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Krieg T; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Mulvey JF; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Yadav P; School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Cobley JN; Division of Sport and Exercise Sciences, Abertay University, Dundee DD1 1HG, UK.
Bright TP; MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.
Senn HM; WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
Anderson RF; School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK. Electronic address: .
Hartley RC; WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK. Electronic address: .
Pokaż więcej
Źródło :
Cell chemical biology [Cell Chem Biol] 2017 Oct 19; Vol. 24 (10), pp. 1285-1298.e12. Date of Electronic Publication: 2017 Sep 07.
Typ publikacji :
Journal Article
MeSH Terms :
Mitochondria/*metabolism
Molecular Probes/*metabolism
Superoxides/*metabolism
Animals ; Biological Transport ; Cell Line ; DNA/chemistry ; DNA/metabolism ; Male ; Mass Spectrometry ; Mice ; Models, Molecular ; Molecular Probes/chemistry ; Nucleic Acid Conformation ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Identification and quantification of protein S -nitrosation by nitrite in the mouse heart during ischemia.
Autorzy :
Chouchani ET; From the Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02284-9168, .; the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115.
James AM; the Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom, and .
Methner C; the Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom.
Pell VR; the Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom.
Prime TA; the Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom, and.
Erickson BK; From the Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02284-9168.; the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115.
Forkink M; the Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom, and.
Lau GY; the Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom, and.
Bright TP; the Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom, and.
Menger KE; the Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom, and.
Fearnley IM; the Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom, and.
Krieg T; the Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom.
Murphy MP; the Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom, and .
Pokaż więcej
Źródło :
The Journal of biological chemistry [J Biol Chem] 2017 Sep 01; Vol. 292 (35), pp. 14486-14495. Date of Electronic Publication: 2017 Jul 14.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Protein Processing, Post-Translational*
Up-Regulation*/drug effects
Mitochondria, Heart/*metabolism
Myocardial Ischemia/*metabolism
Myocardium/*metabolism
Nitrites/*metabolism
Affinity Labels/metabolism ; Animals ; Cardiotonic Agents/pharmacology ; Cell Membrane Permeability/drug effects ; Cysteine/metabolism ; Female ; Heart/drug effects ; Mice ; Mice, Inbred C57BL ; Mitochondria, Heart/drug effects ; Mitochondria, Liver/drug effects ; Mitochondria, Liver/metabolism ; Mitochondrial Swelling/drug effects ; Myocardial Ischemia/drug therapy ; Nitrates/pharmacology ; Nitrites/pharmacology ; Nitrosation/drug effects ; Potassium Compounds/pharmacology ; Proteomics/methods ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Assessment of H 2 S in vivo using the newly developed mitochondria-targeted mass spectrometry probe MitoA.
Autorzy :
Arndt S; From the MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, United Kingdom.
Baeza-Garza CD; the WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
Logan A; From the MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, United Kingdom.
Rosa T; the Department of Medicine, University of Cambridge, Biomedical Campus, Cambridge, CB2 2QQ, United Kingdom.
Wedmann R; the Department of Chemistry and Pharmacy, Friedrich-Alexander University of Erlangen-Nuremberg, Egerlandstrasse,1, 91058 Erlangen, Germany.
Prime TA; From the MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, United Kingdom.
Martin JL; the Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge CB2 2QQ, United Kingdom.
Saeb-Parsy K; the Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge CB2 2QQ, United Kingdom.
Krieg T; the Department of Medicine, University of Cambridge, Biomedical Campus, Cambridge, CB2 2QQ, United Kingdom.
Filipovic MR; the Department of Chemistry and Pharmacy, Friedrich-Alexander University of Erlangen-Nuremberg, Egerlandstrasse,1, 91058 Erlangen, Germany.; the University of Bordeaux, IBGC, UMR 5095, F-33077 Bordeaux, France, and.
Hartley RC; the WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom, .
Murphy MP; From the MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge CB2 0XY, United Kingdom, .
Pokaż więcej
Źródło :
The Journal of biological chemistry [J Biol Chem] 2017 May 12; Vol. 292 (19), pp. 7761-7773. Date of Electronic Publication: 2017 Mar 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hydrogen Sulfide/*chemistry
Mass Spectrometry/*methods
Mitochondria/*metabolism
Animals ; Cations ; Cell Line ; Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Female ; HCT116 Cells ; Heterocyclic Compounds/chemistry ; Humans ; Hypoxia ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Myocardial Ischemia/metabolism ; Organophosphorus Compounds/chemistry ; Rats, Wistar ; Tandem Mass Spectrometry ; Temperature ; Ultraviolet Rays
Czasopismo naukowe
Tytuł :
Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry.
Autorzy :
Logan A; Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Pell VR; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK.
Shaffer KJ; Department of Chemistry, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.
Evans C; Department of Chemistry, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.
Stanley NJ; Department of Chemistry, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.
Robb EL; Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Prime TA; Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Chouchani ET; Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK; Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Department of Cell Biology, Harvard University Medical School, Boston, MA 02115, USA.
Cochemé HM; Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, Gower Street, London WC1E 6BT, UK; MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK.
Fearnley IM; Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Vidoni S; Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
James AM; Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Porteous CM; Department of Chemistry, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand; Department Department of Biochemistry, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.
Partridge L; Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, Gower Street, London WC1E 6BT, UK.
Krieg T; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK.
Smith RA; Department of Chemistry, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.
Murphy MP; Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK. Electronic address: .
Pokaż więcej
Źródło :
Cell metabolism [Cell Metab] 2016 Feb 09; Vol. 23 (2), pp. 379-85. Date of Electronic Publication: 2015 Dec 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Membrane Potential, Mitochondrial*
Click Chemistry/*methods
Tandem Mass Spectrometry/*methods
Animals ; Cell Line ; Mice, Inbred C57BL ; Molecular Probes/metabolism
Czasopismo naukowe
Tytuł :
Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat.
Autorzy :
Robb EL; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Gawel JM; WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
Aksentijević D; King's College London, British Heart Foundation Centre of Research Excellence, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK.
Cochemé HM; MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK.
Stewart TS; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Shchepinova MM; WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
Qiang H; Key Laboratory of Adolescent Health Assessment and Exercise Intervention, Ministry of Education, East China Normal University, Shanghai 200241, China; College of Physical Education and Health, East China Normal University, Shanghai 200241, China.
Prime TA; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Bright TP; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
James AM; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Shattock MJ; King's College London, British Heart Foundation Centre of Research Excellence, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK.
Senn HM; WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
Hartley RC; WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK. Electronic address: .
Murphy MP; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK. Electronic address: .
Pokaż więcej
Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2015 Dec; Vol. 89, pp. 883-94. Date of Electronic Publication: 2015 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Herbicides/*pharmacology
Mitochondria, Heart/*metabolism
Mitochondria, Liver/*metabolism
Oxidative Stress/*drug effects
Paraquat/*pharmacology
Superoxides/*metabolism
Animals ; Apoptosis/drug effects ; Blotting, Western ; Cell Proliferation/drug effects ; Cells, Cultured ; Drosophila melanogaster/drug effects ; Drosophila melanogaster/metabolism ; Electron Transport Complex I ; Female ; HCT116 Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria, Heart/drug effects ; Mitochondria, Liver/drug effects ; Myoblasts/cytology ; Myoblasts/drug effects ; Myoblasts/metabolism ; Oxidation-Reduction ; Rats ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
A mitochondria-targeted derivative of ascorbate: MitoC.
Autorzy :
Finichiu PG; MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UK.
Larsen DS; Department of Chemistry, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.
Evans C; Department of Chemistry, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.
Larsen L; Department of Chemistry, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.
Bright TP; MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UK.
Robb EL; MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UK.
Trnka J; Laboratory for Metabolism and Bioenergetics, Third Faculty of Medicine, Charles University, 100 00 Prague 10, Czech Republic.
Prime TA; MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UK.
James AM; MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UK.
Smith RA; Department of Chemistry, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.
Murphy MP; MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UK. Electronic address: .
Pokaż więcej
Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2015 Dec; Vol. 89, pp. 668-78. Date of Electronic Publication: 2015 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants/*chemistry
Antioxidants/*pharmacology
Ascorbic Acid/*chemistry
Ascorbic Acid/*pharmacology
Drug Delivery Systems/*methods
Mitochondria, Liver/*metabolism
Animals ; Chromatography, High Pressure Liquid ; Female ; Mitochondria, Liver/drug effects ; Oxidation-Reduction ; Oxidative Stress/drug effects ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model.
Autorzy :
Dare AJ; Medical Research Council Mitochondrial Biology Unit, University of Cambridge and the National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.
Logan A; Medical Research Council Mitochondrial Biology Unit, University of Cambridge and the National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.
Prime TA; Medical Research Council Mitochondrial Biology Unit, University of Cambridge and the National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.
Rogatti S; Medical Research Council Mitochondrial Biology Unit, University of Cambridge and the National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.
Goddard M; Papworth Hospital National Health Service Foundation Trust, Papworth Everard, Cambridge, United Kingdom.
Bolton EM; Department of Surgery, University of Cambridge, and the National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.
Bradley JA; Department of Surgery, University of Cambridge, and the National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.
Pettigrew GJ; Department of Surgery, University of Cambridge, and the National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.
Murphy MP; Medical Research Council Mitochondrial Biology Unit, University of Cambridge and the National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom. Electronic address: .
Saeb-Parsy K; Department of Surgery, University of Cambridge, and the National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.
Pokaż więcej
Źródło :
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation [J Heart Lung Transplant] 2015 Nov; Vol. 34 (11), pp. 1471-80. Date of Electronic Publication: 2015 Jun 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Heart Transplantation*
Antioxidants/*therapeutic use
Mitochondria, Heart/*metabolism
Organophosphorus Compounds/*therapeutic use
Primary Graft Dysfunction/*etiology
Reperfusion Injury/*prevention & control
Ubiquinone/*analogs & derivatives
Animals ; Disease Models, Animal ; Female ; Free Radical Scavengers/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Micronutrients/therapeutic use ; Mitochondria, Heart/pathology ; Organ Preservation ; Oxidative Stress ; Primary Graft Dysfunction/metabolism ; Primary Graft Dysfunction/pathology ; Rats ; Rats, Wistar ; Reactive Oxygen Species ; Reperfusion Injury/etiology ; Reperfusion Injury/metabolism ; Ubiquinone/therapeutic use
Czasopismo naukowe
Tytuł :
In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice.
Autorzy :
Logan A; MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge, CB2 0XY, UK.
Shabalina IG
Prime TA
Rogatti S
Kalinovich AV
Hartley RC
Budd RC
Cannon B
Murphy MP
Pokaż więcej
Źródło :
Aging cell [Aging Cell] 2014 Aug; Vol. 13 (4), pp. 765-8. Date of Electronic Publication: 2014 Mar 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging/*metabolism
DNA, Mitochondrial/*metabolism
Hydrogen Peroxide/*metabolism
Mitochondria/*metabolism
Mutation/*genetics
Aging/blood ; Aging/drug effects ; Animals ; Cytokines/blood ; Lipopolysaccharides/pharmacology ; Mice ; Mitochondria/drug effects ; Organophosphorus Compounds/pharmacology
Czasopismo naukowe
Tytuł :
A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes.
Autorzy :
Pun PB; MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UK.
Logan A; MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UK.
Darley-Usmar V; Department of Pathology, Centre for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Chacko B; Department of Pathology, Centre for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Johnson MS; Department of Pathology, Centre for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Huang GW; Department of Pathology, Centre for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Rogatti S; MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UK.
Prime TA; MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UK.
Methner C; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
Krieg T; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
Fearnley IM; MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UK.
Larsen L; Department of Chemistry, University of Otago, Dunedin, New Zealand.
Larsen DS; Department of Chemistry, University of Otago, Dunedin, New Zealand.
Menger KE; MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UK.
Collins Y; MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UK.
James AM; MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UK.
Kumar GD; Centre for the Chemical Research of Ageing, WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
Hartley RC; Centre for the Chemical Research of Ageing, WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
Smith RA; Department of Chemistry, University of Otago, Dunedin, New Zealand.
Murphy MP; MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UK. Electronic address: .
Pokaż więcej
Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2014 Feb; Vol. 67, pp. 437-50. Date of Electronic Publication: 2013 Dec 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Type 1/*metabolism
Glyoxal/*analysis
Hyperglycemia/*metabolism
Mitochondria, Liver/*metabolism
Molecular Probes/*chemical synthesis
Pyruvaldehyde/*analysis
Animals ; Cattle ; Cell Line ; Chromatography, Liquid ; Diabetes Mellitus, Type 1/diagnosis ; Diabetes Mellitus, Type 1/pathology ; Disease Models, Animal ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Glyoxal/metabolism ; Hyperglycemia/diagnosis ; Hyperglycemia/pathology ; Mice ; Mitochondria, Liver/pathology ; Myoblasts/metabolism ; Myoblasts/pathology ; Organophosphorus Compounds/chemistry ; Oxidative Stress ; Phenylenediamines/chemistry ; Pyruvaldehyde/metabolism ; Rats ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Using exomarkers to assess mitochondrial reactive species in vivo.
Autorzy :
Logan A; MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Cochemé HM
Li Pun PB
Apostolova N
Smith RA
Larsen L
Larsen DS
James AM
Fearnley IM
Rogatti S
Prime TA
Finichiu PG
Dare A
Chouchani ET
Pell VR
Methner C
Quin C
McQuaker SJ
Krieg T
Hartley RC
Murphy MP
Pokaż więcej
Źródło :
Biochimica et biophysica acta [Biochim Biophys Acta] 2014 Feb; Vol. 1840 (2), pp. 923-30. Date of Electronic Publication: 2013 May 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Models, Biological*
Molecular Probes*
Biomarkers/*analysis
Mitochondria/*metabolism
Reactive Oxygen Species/*analysis
Animals ; Mice ; Oxidative Stress
Czasopismo naukowe
Tytuł :
The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease.
Autorzy :
Solesio ME; Unidad de Neuropsicofarmacología Traslacional, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
Prime TA
Logan A
Murphy MP
Del Mar Arroyo-Jimenez M
Jordán J
Galindo MF
Pokaż więcej
Źródło :
Biochimica et biophysica acta [Biochim Biophys Acta] 2013 Jan; Vol. 1832 (1), pp. 174-82. Date of Electronic Publication: 2012 Jul 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antioxidants/*metabolism
Mitochondria/*drug effects
Mitochondrial Dynamics/*drug effects
Organophosphorus Compounds/*pharmacology
Oxidopamine/*pharmacology
Parkinson Disease/*physiopathology
Ubiquinone/*analogs & derivatives
Cell Line ; Humans ; Mitochondria/metabolism ; Oxidative Stress/drug effects ; Parkinson Disease/drug therapy ; Parkinson Disease/metabolism ; Reactive Oxygen Species/metabolism ; Ubiquinone/pharmacology
Czasopismo naukowe
Tytuł :
Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species.
Autorzy :
Hurd TR; Mitochondrial Biology Unit, Medical Research Council, Cambridge CB2 0XY, United Kingdom.
Collins Y
Abakumova I
Chouchani ET
Baranowski B
Fearnley IM
Prime TA
Murphy MP
James AM
Pokaż więcej
Źródło :
The Journal of biological chemistry [J Biol Chem] 2012 Oct 12; Vol. 287 (42), pp. 35153-60. Date of Electronic Publication: 2012 Aug 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hydrogen Peroxide/*metabolism
Mitochondria, Heart/*enzymology
Mitochondrial Proteins/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Pyruvate Dehydrogenase Complex/*metabolism
Superoxides/*metabolism
Adenosine Triphosphate/biosynthesis ; Animals ; Citric Acid Cycle/physiology ; HEK293 Cells ; Humans ; Mitochondria, Heart/genetics ; Mitochondrial Proteins/genetics ; Protein-Serine-Threonine Kinases/genetics ; Pyruvate Dehydrogenase Acetyl-Transferring Kinase ; Pyruvate Dehydrogenase Complex/genetics ; Rats ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
A ratiometric fluorescent probe for assessing mitochondrial phospholipid peroxidation within living cells.
Autorzy :
Prime TA; MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge, UK.
Forkink M
Logan A
Finichiu PG
McLachlan J
Li Pun PB
Koopman WJ
Larsen L
Latter MJ
Smith RA
Murphy MP
Pokaż więcej
Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2012 Aug 01; Vol. 53 (3), pp. 544-53. Date of Electronic Publication: 2012 May 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lipid Peroxidation*
Boron Compounds/*metabolism
Fluorescent Dyes/*metabolism
Mitochondrial Membranes/*metabolism
Phosphines/*metabolism
Phospholipids/*metabolism
Staining and Labeling/*methods
Animals ; Boron Compounds/chemical synthesis ; Boron Compounds/chemistry ; Ethanol/chemistry ; Fluorescent Dyes/chemical synthesis ; Fluorescent Dyes/chemistry ; HEK293 Cells ; Humans ; Hydrogen Peroxide/pharmacology ; Mice ; Mitochondria/metabolism ; Organic Chemicals/metabolism ; Oxidants/pharmacology ; Oxidation-Reduction ; Phosphines/chemical synthesis ; Phosphines/chemistry ; Solvents/chemistry ; Spectrometry, Fluorescence
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies