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Tytuł :
The N-terminal domain of Arabidopsis proline dehydrogenase affects enzymatic activity and protein oligomerization.
Autorzy :
Fabro G; Centro de Investigaciones en Química Biológica de Córdoba, CIQUIBIC, CONICET, Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, X5000HUA, Córdoba, Argentina. Electronic address: .
Cislaghi AP; Centro de Investigaciones en Química Biológica de Córdoba, CIQUIBIC, CONICET, Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, X5000HUA, Córdoba, Argentina.
Condat F; Centro de Investigaciones en Química Biológica de Córdoba, CIQUIBIC, CONICET, Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, X5000HUA, Córdoba, Argentina.
Deza Borau G; Centro de Investigaciones en Química Biológica de Córdoba, CIQUIBIC, CONICET, Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, X5000HUA, Córdoba, Argentina.
Alvarez ME; Centro de Investigaciones en Química Biológica de Córdoba, CIQUIBIC, CONICET, Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, X5000HUA, Córdoba, Argentina. Electronic address: .
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Źródło :
Plant physiology and biochemistry : PPB [Plant Physiol Biochem] 2020 Sep; Vol. 154, pp. 268-276. Date of Electronic Publication: 2020 Jun 13.
Typ publikacji :
Journal Article
MeSH Terms :
Arabidopsis/*enzymology
Arabidopsis Proteins/*metabolism
Mitochondrial Proteins/*metabolism
Proline Oxidase/*metabolism
Escherichia coli ; Isoenzymes ; Proline
Czasopismo naukowe
Tytuł :
Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.
Autorzy :
Lee SB; Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA.
Ko A; Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA.
Oh YT; Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA.
Shi P; Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA.
D'Angelo F; Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA.
Frangaj B; Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA.
Koller A; Proteomics Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Chen EI; Proteomics Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Cardozo T; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, NYU Langone Health, New York, NY 10016, USA.
Iavarone A; Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA; Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: .
Lasorella A; Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA; Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Aug 06; Vol. 79 (3), pp. 376-389.e8. Date of Electronic Publication: 2020 Jul 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Protein Processing, Post-Translational*
Brain Neoplasms/*genetics
Glioma/*genetics
Isoenzymes/*genetics
Proline/*metabolism
Protein-Serine-Threonine Kinases/*genetics
Protein-Tyrosine Kinases/*genetics
Von Hippel-Lindau Tumor Suppressor Protein/*genetics
Amino Acid Sequence ; Animals ; Binding Sites ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Crystallography, X-Ray ; Gene Expression Regulation, Neoplastic ; Glioma/metabolism ; Glioma/pathology ; HEK293 Cells ; Heterografts ; Humans ; Hydroxylation ; Hypoxia-Inducible Factor-Proline Dioxygenases/genetics ; Hypoxia-Inducible Factor-Proline Dioxygenases/metabolism ; Isoenzymes/chemistry ; Isoenzymes/metabolism ; Mice ; Mice, Nude ; Mitogen-Activated Protein Kinase 14/chemistry ; Mitogen-Activated Protein Kinase 14/genetics ; Mitogen-Activated Protein Kinase 14/metabolism ; Models, Molecular ; Mutation ; Neuroglia/metabolism ; Neuroglia/pathology ; Phosphorylation ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Structure, Secondary ; Protein-Serine-Threonine Kinases/chemistry ; Protein-Serine-Threonine Kinases/metabolism ; Protein-Tyrosine Kinases/chemistry ; Protein-Tyrosine Kinases/metabolism ; Von Hippel-Lindau Tumor Suppressor Protein/metabolism
Czasopismo naukowe
Tytuł :
Endothelial prolyl hydroxylase 2 is necessary for angiotensin II-mediated renal fibrosis and injury.
Autorzy :
Zhao Y; Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Zeng H; Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Liu B; Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
He X; Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Chen JX; Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2020 Aug 01; Vol. 319 (2), pp. F345-F357. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin II/*metabolism
Endothelial Cells/*metabolism
Fibrosis/*metabolism
Hypoxia-Inducible Factor-Proline Dioxygenases/*metabolism
Kidney/*injuries
Kidney Diseases/*enzymology
Angiotensin II/pharmacology ; Animals ; Endothelial Cells/drug effects ; Endothelium/metabolism ; Hypoxia-Inducible Factor-Proline Dioxygenases/genetics ; Kidney/enzymology ; Mice ; Mice, Knockout ; Procollagen-Proline Dioxygenase/genetics ; Procollagen-Proline Dioxygenase/metabolism ; RNA, Small Interfering/metabolism
Czasopismo naukowe
Tytuł :
Exogenous proline induces regulation in 2-acetyl-1-pyrroline (2-AP) biosynthesis and quality characters in fragrant rice (Oryza sativa L.).
Autorzy :
Luo H; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, 510642, People's Republic of China.; Scientific Observing and Experimental Station of Crop Cultivation in South China, Ministry of Agriculture, Guangzhou, 510642, People's Republic of China.
Zhang T; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, 510642, People's Republic of China.; Scientific Observing and Experimental Station of Crop Cultivation in South China, Ministry of Agriculture, Guangzhou, 510642, People's Republic of China.
Zheng A; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, 510642, People's Republic of China.
He L; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, 510642, People's Republic of China.; Scientific Observing and Experimental Station of Crop Cultivation in South China, Ministry of Agriculture, Guangzhou, 510642, People's Republic of China.
Lai R; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, 510642, People's Republic of China.; Scientific Observing and Experimental Station of Crop Cultivation in South China, Ministry of Agriculture, Guangzhou, 510642, People's Republic of China.
Liu J; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, 510642, People's Republic of China.; Scientific Observing and Experimental Station of Crop Cultivation in South China, Ministry of Agriculture, Guangzhou, 510642, People's Republic of China.
Xing P; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, 510642, People's Republic of China.; Scientific Observing and Experimental Station of Crop Cultivation in South China, Ministry of Agriculture, Guangzhou, 510642, People's Republic of China.
Tang X; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, 510642, People's Republic of China. .; Scientific Observing and Experimental Station of Crop Cultivation in South China, Ministry of Agriculture, Guangzhou, 510642, People's Republic of China. .
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Źródło :
Scientific reports [Sci Rep] 2020 Aug 18; Vol. 10 (1), pp. 13971. Date of Electronic Publication: 2020 Aug 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Oryza/*genetics
Proline/*metabolism
Pyrroles/*metabolism
China ; Edible Grain/metabolism ; Gene Expression Regulation, Plant/genetics ; Oryza/growth & development ; Plant Proteins/genetics ; Proline Oxidase/genetics
Czasopismo naukowe
Tytuł :
Structural analysis of prolines and hydroxyprolines binding to the l-glutamate-γ-semialdehyde dehydrogenase active site of bifunctional proline utilization A.
Autorzy :
Campbell AC; Department of Biochemistry, University of Missouri, Columbia, MO, 65211, United States.
Bogner AN; Department of Biochemistry, University of Missouri, Columbia, MO, 65211, United States.
Mao Y; Department of Biochemistry, Redox Biology Center, University of Nebraska, Lincoln, NE, 68588, United States.
Becker DF; Department of Biochemistry, Redox Biology Center, University of Nebraska, Lincoln, NE, 68588, United States.
Tanner JJ; Department of Biochemistry, University of Missouri, Columbia, MO, 65211, United States; Department of Chemistry, University of Missouri, Columbia, MO, 65211, United States. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Feb 15; Vol. 698, pp. 108727. Date of Electronic Publication: 2020 Dec 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*metabolism
Enzyme Inhibitors/*metabolism
Glutamate-5-Semialdehyde Dehydrogenase/*metabolism
Hydroxyproline/*metabolism
Membrane Proteins/*metabolism
Proline/*metabolism
Bacterial Proteins/chemistry ; Catalytic Domain ; Crystallography, X-Ray ; Enzyme Inhibitors/chemistry ; Glutamate-5-Semialdehyde Dehydrogenase/chemistry ; Hydroxyproline/chemistry ; Membrane Proteins/chemistry ; Proline/chemistry ; Protein Binding ; Sinorhizobium meliloti/enzymology ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir.
Autorzy :
Bai Y; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Ye F; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, 102206, China.
Feng Y; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Liao H; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Song H; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China.
Qi J; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Gao GF; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.; Center for Influenza Research and Early Warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Disease (CEEID), Chinese Academy of Sciences, Beijing, 100101, China.
Tan W; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China. .
Fu L; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. .; Center for Influenza Research and Early Warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Disease (CEEID), Chinese Academy of Sciences, Beijing, 100101, China. .
Shi Y; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China. .; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. .; Center for Influenza Research and Early Warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Disease (CEEID), Chinese Academy of Sciences, Beijing, 100101, China. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2021 Feb 04; Vol. 6 (1), pp. 51. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronavirus 3C Proteases*/antagonists & inhibitors
Coronavirus 3C Proteases*/chemistry
COVID-19/*enzymology
Cyclopropanes/*chemistry
Cysteine Proteinase Inhibitors/*chemistry
Leucine/*analogs & derivatives
Proline/*analogs & derivatives
SARS-CoV-2/*enzymology
Sulfones/*chemistry
Urea/*chemistry
COVID-19/drug therapy ; Cyclopropanes/pharmacology ; Cysteine Proteinase Inhibitors/pharmacology ; Hepacivirus/enzymology ; Humans ; Leucine/chemistry ; Leucine/pharmacology ; Proline/chemistry ; Proline/pharmacology ; Sulfones/pharmacology ; Urea/pharmacology
Raport
Tytuł :
Characterization of Vixotrigine, a Broad-Spectrum Voltage-Gated Sodium Channel Blocker.
Autorzy :
Hinckley CA; Biogen, Cambridge, Massachusetts (C.A.H., H.N.); Charles River Laboratories Cleveland, Inc., Cleveland, Ohio (Y.K.); Neuroservice, Aix-en-Provence, France (A.S., A.B., B.B.); and Department of Comparative Medicine, Yale University, New Haven, Connecticut (M.H.) .
Kuryshev Y; Biogen, Cambridge, Massachusetts (C.A.H., H.N.); Charles River Laboratories Cleveland, Inc., Cleveland, Ohio (Y.K.); Neuroservice, Aix-en-Provence, France (A.S., A.B., B.B.); and Department of Comparative Medicine, Yale University, New Haven, Connecticut (M.H.).
Sers A; Biogen, Cambridge, Massachusetts (C.A.H., H.N.); Charles River Laboratories Cleveland, Inc., Cleveland, Ohio (Y.K.); Neuroservice, Aix-en-Provence, France (A.S., A.B., B.B.); and Department of Comparative Medicine, Yale University, New Haven, Connecticut (M.H.).
Barre A; Biogen, Cambridge, Massachusetts (C.A.H., H.N.); Charles River Laboratories Cleveland, Inc., Cleveland, Ohio (Y.K.); Neuroservice, Aix-en-Provence, France (A.S., A.B., B.B.); and Department of Comparative Medicine, Yale University, New Haven, Connecticut (M.H.).
Buisson B; Biogen, Cambridge, Massachusetts (C.A.H., H.N.); Charles River Laboratories Cleveland, Inc., Cleveland, Ohio (Y.K.); Neuroservice, Aix-en-Provence, France (A.S., A.B., B.B.); and Department of Comparative Medicine, Yale University, New Haven, Connecticut (M.H.).
Naik H; Biogen, Cambridge, Massachusetts (C.A.H., H.N.); Charles River Laboratories Cleveland, Inc., Cleveland, Ohio (Y.K.); Neuroservice, Aix-en-Provence, France (A.S., A.B., B.B.); and Department of Comparative Medicine, Yale University, New Haven, Connecticut (M.H.).
Hajos M; Biogen, Cambridge, Massachusetts (C.A.H., H.N.); Charles River Laboratories Cleveland, Inc., Cleveland, Ohio (Y.K.); Neuroservice, Aix-en-Provence, France (A.S., A.B., B.B.); and Department of Comparative Medicine, Yale University, New Haven, Connecticut (M.H.).
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2021 Jan; Vol. 99 (1), pp. 49-59.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Phenyl Ethers/*metabolism
Phenyl Ethers/*pharmacology
Proline/*analogs & derivatives
Voltage-Gated Sodium Channel Blockers/*metabolism
Voltage-Gated Sodium Channel Blockers/*pharmacology
Voltage-Gated Sodium Channels/*physiology
Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Dose-Response Relationship, Drug ; Female ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/physiology ; HEK293 Cells ; Humans ; Male ; Phenyl Ethers/chemistry ; Proline/chemistry ; Proline/metabolism ; Proline/pharmacology ; Rats ; Rats, Sprague-Dawley ; Voltage-Gated Sodium Channel Blockers/chemistry ; Voltage-Gated Sodium Channels/chemistry
Czasopismo naukowe
Tytuł :
Affinity-Triggered Assemblies Based on a Designed Peptide-Peptide Affinity Pair.
Autorzy :
Fernandes CSM; UCIBIO, Departamento de Química, Faculdade de Ciências e Tecnologia, UCIBIO, Universidade NOVA de Lisboa, Campus Caparica, 2829-516, Caparica, Portugal.
Pina AS; UCIBIO, Departamento de Química, Faculdade de Ciências e Tecnologia, UCIBIO, Universidade NOVA de Lisboa, Campus Caparica, 2829-516, Caparica, Portugal.
Moura Barbosa AJ; UCIBIO, Departamento de Química, Faculdade de Ciências e Tecnologia, UCIBIO, Universidade NOVA de Lisboa, Campus Caparica, 2829-516, Caparica, Portugal.
Padrão I; UCIBIO, Departamento de Química, Faculdade de Ciências e Tecnologia, UCIBIO, Universidade NOVA de Lisboa, Campus Caparica, 2829-516, Caparica, Portugal.
Duarte F; LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, 4169-007, Porto, Portugal.
Teixeira CAS; LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, 4169-007, Porto, Portugal.
Alves V; LEAF, Linking Landscape, Environment, Agriculture and Food, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017, Lisboa, Portugal.
Gomes P; LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, 4169-007, Porto, Portugal.
Fernandes TG; Department of Bioengineering, iBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001, Lisboa, Portugal.; The Discoveries Centre for Regenerative and Precision Medicine, Universidade de Lisboa, Lisbon Campus, 1049-001, Lisboa, Portugal.
Carvalho Dias AMG; UCIBIO, Departamento de Química, Faculdade de Ciências e Tecnologia, UCIBIO, Universidade NOVA de Lisboa, Campus Caparica, 2829-516, Caparica, Portugal.
Roque ACA; UCIBIO, Departamento de Química, Faculdade de Ciências e Tecnologia, UCIBIO, Universidade NOVA de Lisboa, Campus Caparica, 2829-516, Caparica, Portugal.
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Źródło :
Biotechnology journal [Biotechnol J] 2019 Nov; Vol. 14 (11), pp. e1800559. Date of Electronic Publication: 2019 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
Proline-Rich Protein Domains*
WW Domains*
Peptides/*chemistry
Biocompatible Materials ; Culture Media ; Hydrogels/chemistry ; Ligands ; Proline/chemistry ; Protein Binding ; Rheology
Czasopismo naukowe
Tytuł :
Acute toxicity of dihydroanatoxin-a from Microcoleus autumnalis in comparison to anatoxin-a.
Autorzy :
Puddick J; Cawthron Institute, Private Bag 2, Nelson, 7042, New Zealand. Electronic address: .
van Ginkel R; Cawthron Institute, Private Bag 2, Nelson, 7042, New Zealand.
Page CD; Cawthron Institute, Private Bag 2, Nelson, 7042, New Zealand.
Murray JS; Cawthron Institute, Private Bag 2, Nelson, 7042, New Zealand.
Greenhough HE; Cawthron Institute, Private Bag 2, Nelson, 7042, New Zealand.
Bowater J; Cawthron Institute, Private Bag 2, Nelson, 7042, New Zealand.
Selwood AI; Cawthron Institute, Private Bag 2, Nelson, 7042, New Zealand.
Wood SA; Cawthron Institute, Private Bag 2, Nelson, 7042, New Zealand.
Prinsep MR; Chemistry, School of Science, University of Waikato, Private Bag 3105, Hamilton, 3240, New Zealand.
Truman P; Massey University, PO Box 756, Wellington, 6140, New Zealand.
Munday R; AgResearch Limited, Ruakura Research Centre, Private Bag 3123, Hamilton, 3240, New Zealand.
Finch SC; AgResearch Limited, Ruakura Research Centre, Private Bag 3123, Hamilton, 3240, New Zealand.
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Źródło :
Chemosphere [Chemosphere] 2021 Jan; Vol. 263, pp. 127937. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article
MeSH Terms :
Cyanobacteria/*metabolism
Proline/*analogs & derivatives
Tropanes/*toxicity
Animals ; Bacterial Toxins/toxicity ; Bridged Bicyclo Compounds, Heterocyclic/toxicity ; Cyanobacteria/chemistry ; Dogs ; Humans ; Mice ; Proline/toxicity ; Rivers/chemistry
Czasopismo naukowe
Tytuł :
Hydrogen peroxide alleviates salinity-induced damage through enhancing proline accumulation in wheat seedlings.
Autorzy :
Liu L; MOE Key Laboratory of Environment Remediation and Ecological Health, College of Natural Resource and Environmental Sciences, Zhejiang University, Hangzhou, 310058, China.
Huang L; MOE Key Laboratory of Environment Remediation and Ecological Health, College of Natural Resource and Environmental Sciences, Zhejiang University, Hangzhou, 310058, China.
Lin X; MOE Key Laboratory of Environment Remediation and Ecological Health, College of Natural Resource and Environmental Sciences, Zhejiang University, Hangzhou, 310058, China.
Sun C; MOE Key Laboratory of Environment Remediation and Ecological Health, College of Natural Resource and Environmental Sciences, Zhejiang University, Hangzhou, 310058, China. .
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Źródło :
Plant cell reports [Plant Cell Rep] 2020 May; Vol. 39 (5), pp. 567-575. Date of Electronic Publication: 2020 Feb 06.
Typ publikacji :
Journal Article
MeSH Terms :
Hydrogen Peroxide/*pharmacology
NADPH Oxidases/*antagonists & inhibitors
Plant Roots/*metabolism
Proline/*metabolism
Salt Stress/*drug effects
Seedlings/*metabolism
Triticum/*metabolism
Cell Membrane/drug effects ; Cell Membrane/metabolism ; Cell Membrane/pathology ; Hydrogen Peroxide/metabolism ; Lipid Peroxidation/drug effects ; NADPH Oxidases/metabolism ; Onium Compounds/pharmacology ; Ornithine-Oxo-Acid Transaminase/metabolism ; Plant Roots/drug effects ; Proline Oxidase/metabolism ; Salinity ; Salt Stress/physiology ; Salt Tolerance/drug effects ; Salt Tolerance/physiology ; Seedlings/drug effects ; Seedlings/enzymology ; Thiourea/analogs & derivatives ; Thiourea/pharmacology ; Triticum/drug effects ; Triticum/enzymology
Czasopismo naukowe
Tytuł :
Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis.
Autorzy :
Choi UY; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
Lee JJ; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
Park A; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
Zhu W; Department of NanoEngineering, University of California San Diego, La Jolla, CA 92093.
Lee HR; Department of Biotechnology and Bioinformatics, College of Science and Technology, Korea University, 30019 Sejong, South Korea.
Choi YJ; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
Yoo JS; Department of Immunology, Faculty of Medicine, Hokkaido University, 060-8638 Sapporo, Japan.
Yu C; Department of NanoEngineering, University of California San Diego, La Jolla, CA 92093.
Feng P; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.; Section of Infection and Immunity, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90089.
Gao SJ; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.; University of Pittsburgh Medical Center (UPMC), Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219.; Laboratory of Human Virology and Oncology, Shantou University Medical College, 515041 Shantou, Guangdong, China.
Chen S; Department of NanoEngineering, University of California San Diego, La Jolla, CA 92093.
Eoh H; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033; .
Jung JU; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Apr 07; Vol. 117 (14), pp. 8083-8093. Date of Electronic Publication: 2020 Mar 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Transformation, Neoplastic/*pathology
Herpesvirus 8, Human/*metabolism
Proline/*metabolism
Pyrroline Carboxylate Reductases/*metabolism
Sarcoma, Kaposi/*pathology
Viral Proteins/*metabolism
Animals ; Cell Culture Techniques/methods ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Metabolomics ; Mice ; Proline Oxidase/metabolism ; Sarcoma, Kaposi/virology ; Spheroids, Cellular ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
PRPs localized to the middle lamellae are required for cortical tissue integrity in Medicago truncatula roots.
Autorzy :
Erickson BJ; Biomolecular Science and Engineering Program, University of California at Santa Barbara, Santa Barbara, CA, 93106, USA.; Biological Sciences Department, Santa Rosa Junior College, Santa Rosa, CA, 95401, USA.
Staples NC; Molecular, Cellular, and Developmental Biology Department, University of California at Santa Barbara, Santa Barbara, CA, 93106, USA.; Biological Sciences Department, Cañada College, Redwood City, CA, 94061, USA.
Hess N; Molecular, Cellular, and Developmental Biology Department, University of California at Santa Barbara, Santa Barbara, CA, 93106, USA.
Staples MA; Molecular, Cellular, and Developmental Biology Department, University of California at Santa Barbara, Santa Barbara, CA, 93106, USA.
Weissert C; Molecular, Cellular, and Developmental Biology Department, University of California at Santa Barbara, Santa Barbara, CA, 93106, USA.; Biology Department, Universität Hamburg, 22609, Hamburg, Germany.
Finkelstein RR; Molecular, Cellular, and Developmental Biology Department, University of California at Santa Barbara, Santa Barbara, CA, 93106, USA. .
Cooper JB; Molecular, Cellular, and Developmental Biology Department, University of California at Santa Barbara, Santa Barbara, CA, 93106, USA.; Biomolecular Science and Engineering Program, University of California at Santa Barbara, Santa Barbara, CA, 93106, USA.
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Źródło :
Plant molecular biology [Plant Mol Biol] 2020 Apr; Vol. 102 (6), pp. 571-588. Date of Electronic Publication: 2020 Jan 11.
Typ publikacji :
Journal Article
MeSH Terms :
Medicago truncatula/*metabolism
Plant Proteins/*genetics
Plant Proteins/*metabolism
Plant Roots/*metabolism
Proline-Rich Protein Domains/*genetics
Cell Wall/metabolism ; Gene Expression Regulation, Plant ; Gene Knockdown Techniques ; Genetic Vectors ; Glucuronidase ; Medicago truncatula/genetics ; Plant Roots/cytology ; Plant Roots/genetics ; Plants, Genetically Modified ; Promoter Regions, Genetic ; Salivary Proline-Rich Proteins ; Xylem/metabolism
Czasopismo naukowe
Tytuł :
First clinical study using HCV protease inhibitor danoprevir to treat COVID-19 patients.
Autorzy :
Chen H; The First Department of Infectious Disease.
Zhang Z; The Intensive Care Unit.
Wang L; The First Department of Infectious Disease.
Huang Z; The Radiology Department.
Gong F; The Second Department of Infectious Disease, The Ninth Hospital of Nanchang, Nanchang 330002, Jiangxi Province.
Li X; Ascletis Bioscience Co., Ltd., Hangzhou 310051.
Chen Y; Ascletis Bioscience Co., Ltd., Hangzhou 310051.
Wu JJ; Ascletis Bioscience Co., Ltd., Hangzhou 310051.; Ascletis Pharmaceuticals Co., Ltd., Shaoxing 310051, Zhejiang Province, China.
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Nov 25; Vol. 99 (48), pp. e23357.
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Cyclopropanes/*therapeutic use
Isoindoles/*therapeutic use
Lactams, Macrocyclic/*therapeutic use
Proline/*analogs & derivatives
Ritonavir/*therapeutic use
Sulfonamides/*therapeutic use
Adolescent ; Adult ; Aged ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; COVID-19/diagnostic imaging ; Cyclopropanes/administration & dosage ; Cyclopropanes/adverse effects ; Drug Therapy, Combination ; Female ; Humans ; Isoindoles/administration & dosage ; Isoindoles/adverse effects ; Lactams, Macrocyclic/administration & dosage ; Lactams, Macrocyclic/adverse effects ; Male ; Middle Aged ; Pandemics ; Proline/administration & dosage ; Proline/adverse effects ; Proline/therapeutic use ; Real-Time Polymerase Chain Reaction ; Ritonavir/administration & dosage ; Ritonavir/adverse effects ; SARS-CoV-2 ; Sulfonamides/administration & dosage ; Sulfonamides/adverse effects ; Tomography, X-Ray Computed ; Young Adult
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Sprr2f protects against renal injury by decreasing the level of reactive oxygen species in female mice.
Autorzy :
Huynh KM; Department of Urology, School of Medicine, Stanford University, Stanford, California.
Wong AC; Department of Urology, School of Medicine, Stanford University, Stanford, California.
Wu B; Department of Urology, School of Medicine, Stanford University, Stanford, California.
Horschman M; Department of Urology, School of Medicine, Stanford University, Stanford, California.
Zhao H; Department of Urology, School of Medicine, Stanford University, Stanford, California.
Brooks JD; Department of Urology, School of Medicine, Stanford University, Stanford, California.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2020 Nov 01; Vol. 319 (5), pp. F876-F884. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cornified Envelope Proline-Rich Proteins/*metabolism
Epithelial Cells/*metabolism
Kidney/*metabolism
Reactive Oxygen Species/*metabolism
Animals ; Cornified Envelope Proline-Rich Proteins/genetics ; Disease Models, Animal ; Female ; Kidney Tubules/metabolism ; Mice, Knockout ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/pathology ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology ; Ureteral Obstruction/pathology
Czasopismo naukowe
Tytuł :
PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase.
Autorzy :
D'Hulst G; Department Health Sciences and Technology, Laboratory of Exercise and Health, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.
Soro-Arnaiz I; Department Health Sciences and Technology, Laboratory of Exercise and Health, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.
Masschelein E; Department Health Sciences and Technology, Laboratory of Exercise and Health, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.
Veys K; Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, Leuven, Belgium.; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium.
Fitzgerald G; Department Health Sciences and Technology, Laboratory of Exercise and Health, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.
Smeuninx B; School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.; MRC Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Kim S; Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Gwanak-gu, Seoul, South Korea.
Deldicque L; Institute of Neuroscience, Université catholique de Louvain, Louvain-La-Neuve, Belgium.
Blaauw B; Department of Biomedical Sciences, Venetian Institute of Molecular Medicine, University of Padova, Padova, Italy.
Carmeliet P; Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, Leuven, Belgium.; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium.
Breen L; School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.; MRC Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Koivunen P; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland.
Zhao SM; Obstetrics and Gynaecology Hospital of Fudan University, State Key Lab of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Shanghai, P. R. China.; Institute of Biomedical Science, Fudan University, Shanghai, P. R. China.; Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, P. R. China.
De Bock K; Department Health Sciences and Technology, Laboratory of Exercise and Health, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland. .
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Źródło :
Nature communications [Nat Commun] 2020 Jan 10; Vol. 11 (1), pp. 174. Date of Electronic Publication: 2020 Jan 10.
Typ publikacji :
Journal Article
MeSH Terms :
Leucine-tRNA Ligase/*metabolism
Mechanistic Target of Rapamycin Complex 1/*metabolism
Muscles/*metabolism
Procollagen-Proline Dioxygenase/*metabolism
Adult ; Aged ; Aging/metabolism ; Amino Acids/metabolism ; Animals ; Disease Models, Animal ; Female ; HEK293 Cells ; Humans ; Hydroxylation ; Hypoxia-Inducible Factor-Proline Dioxygenases/metabolism ; Leucine/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Muscle Development ; Muscles/pathology ; Oxygen/metabolism ; Procollagen-Proline Dioxygenase/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
High viral load predicts virologic failure in chronic genotype 2 hepatitis C virus-infected patients receiving glecaprevir/pibrentasvir therapy.
Autorzy :
Chen WM; Division of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Wei KL; Division of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.
Tung SY; Division of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.
Shen CH; Division of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.
Chang TS; Division of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Yen CW; Division of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.
Hsieh YY; Division of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.
Chiu WN; Division of Hepatogastroenterology, Department of Internal Medicine, Yulin Chang Gung Memorial Hospital, Yulin, Taiwan.
Hu JH; Division of Hepatogastroenterology, Department of Internal Medicine, Yulin Chang Gung Memorial Hospital, Yulin, Taiwan.
Lu SN; Division of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Hung CH; Division of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address: .
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Źródło :
Journal of the Formosan Medical Association = Taiwan yi zhi [J Formos Med Assoc] 2020 Nov; Vol. 119 (11), pp. 1593-1600. Date of Electronic Publication: 2020 Aug 21.
Typ publikacji :
Journal Article
MeSH Terms :
Hepatitis C, Chronic*/drug therapy
Aminoisobutyric Acids/*therapeutic use
Benzimidazoles/*therapeutic use
Cyclopropanes/*therapeutic use
Lactams, Macrocyclic/*therapeutic use
Leucine/*analogs & derivatives
Proline/*analogs & derivatives
Quinoxalines/*therapeutic use
Sulfonamides/*therapeutic use
Antiviral Agents/adverse effects ; Benzimidazoles/urine ; Genotype ; Hepacivirus/genetics ; Humans ; Leucine/therapeutic use ; Proline/therapeutic use ; Viral Load
Czasopismo naukowe
Tytuł :
Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells.
Autorzy :
Rostami J; Molecular Geriatrics, Department of Public Health and Caring Sciences, Rudbeck Laboratory, Uppsala University, 751 85, Uppsala, Sweden.
Jäntti M; Division of Pharmacology and Pharmacotherapy/Drug Research Program, University of Helsinki, Viikinkaari 5E, P.O. Box 56, 00014, University of Helsinki, Finland.
Cui H; Division of Pharmacology and Pharmacotherapy/Drug Research Program, University of Helsinki, Viikinkaari 5E, P.O. Box 56, 00014, University of Helsinki, Finland.
Rinne MK; Division of Pharmaceutical Chemistry and Technology/Drug Research Program, Faculty of Pharmacy, P.O. Box 56, 00014, University of Helsinki, Finland.
Kukkonen JP; Department of Pharmacology, Institute of Biomedicine, Faculty of Medicine, P.O. Box 63, 00014, University of Helsinki, Finland.
Falk A; Department of Neuroscience, Karolinska Institutet, Stockholm, 17177, Sweden.
Erlandsson A; Molecular Geriatrics, Department of Public Health and Caring Sciences, Rudbeck Laboratory, Uppsala University, 751 85, Uppsala, Sweden.
Myöhänen T; Division of Pharmacology and Pharmacotherapy/Drug Research Program, University of Helsinki, Viikinkaari 5E, P.O. Box 56, 00014, University of Helsinki, Finland; Integrative Physiology and Pharmacology Unit, Institute of Biomedicine, 20014, University of Turku, Finland. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Nov; Vol. 131, pp. 110788. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article
MeSH Terms :
Neurons/*drug effects
Proline/*analogs & derivatives
Prolyl Oligopeptidases/*antagonists & inhibitors
alpha-Synuclein/*metabolism
Astrocytes/drug effects ; Astrocytes/pathology ; Autophagy/drug effects ; Cell Line, Tumor ; Cells, Cultured ; Disease Progression ; Humans ; Neurons/pathology ; Parkinson Disease/physiopathology ; Proline/pharmacology ; Serine Proteinase Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
Stachydrine promotes angiogenesis by regulating the VEGFR2/MEK/ERK and mitochondrial-mediated apoptosis signaling pathways in human umbilical vein endothelial cells.
Autorzy :
Zhou F; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Liu F; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Liu J; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
He YL; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Zhou QM; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Guo L; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Peng C; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address: .
Xiong L; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Nov; Vol. 131, pp. 110724. Date of Electronic Publication: 2020 Sep 10.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Extracellular Signal-Regulated MAP Kinases/*physiology
Human Umbilical Vein Endothelial Cells/*drug effects
Mitochondria/*physiology
Mitogen-Activated Protein Kinase Kinases/*physiology
Neovascularization, Physiologic/*drug effects
Proline/*analogs & derivatives
Vascular Endothelial Growth Factor Receptor-2/*physiology
Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Human Umbilical Vein Endothelial Cells/physiology ; Humans ; Proline/pharmacology ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Proline improves cardiac remodeling following myocardial infarction and attenuates cardiomyocyte apoptosis via redox regulation.
Autorzy :
Wang J; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China.
Xue Z; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China.
Lin J; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China.
Wang Y; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China.
Ying H; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China.
Lv Q; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China.
Hua C; Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China.
Wang M; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China.
Chen S; Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China.
Zhou B; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Aug; Vol. 178, pp. 114065. Date of Electronic Publication: 2020 May 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Myocardial Infarction/*metabolism
Myocytes, Cardiac/*drug effects
Myocytes, Cardiac/*metabolism
Proline/*pharmacology
Ventricular Remodeling/*drug effects
Animals ; Apoptosis/physiology ; Cell Line ; Male ; Mice ; Mice, Inbred C57BL ; Myocardial Infarction/drug therapy ; Myocardial Infarction/pathology ; Myocytes, Cardiac/pathology ; Oxidation-Reduction/drug effects ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Proline/therapeutic use ; Reactive Oxygen Species/metabolism ; Ventricular Remodeling/physiology
Czasopismo naukowe
Tytuł :
Evaluation of the Potential Pharmacokinetic Interactions Between Vixotrigine and an Oral Contraceptive.
Autorzy :
Zhao Y; Clinical Pharmacology and Pharmacometrics, Biogen, 225 Binney Street, Cambridge, MA, 02142, USA.
Versavel M; vZenium, Arlington, MA, USA.
Tidemann-Miller B; Biostatistics, Biogen, Cambridge, MA, USA.
Christmann R; Global Safety Regulatory Sciences, Biogen, Cambridge, MA, USA.
Naik H; Clinical Pharmacology and Pharmacometrics, Biogen, 225 Binney Street, Cambridge, MA, 02142, USA. .
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Źródło :
Clinical drug investigation [Clin Drug Investig] 2020 Aug; Vol. 40 (8), pp. 737-746.
Typ publikacji :
Journal Article
MeSH Terms :
Contraceptives, Oral, Combined/*pharmacology
Ethinyl Estradiol/*pharmacology
Phenyl Ethers/*pharmacology
Proline/*analogs & derivatives
Adolescent ; Adult ; Contraceptives, Oral, Combined/adverse effects ; Contraceptives, Oral, Combined/pharmacokinetics ; Drug Interactions ; Ethinyl Estradiol/adverse effects ; Female ; Humans ; Levonorgestrel/adverse effects ; Levonorgestrel/pharmacology ; Middle Aged ; Phenyl Ethers/adverse effects ; Proline/adverse effects ; Proline/pharmacology ; Young Adult
Czasopismo naukowe

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