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Tytuł :
NSAIDs Induce Proline Dehydrogenase/Proline Oxidase-Dependent and Independent Apoptosis in MCF7 Breast Cancer Cells.
Autorzy :
Kazberuk A; Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, Poland.
Chalecka M; Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, Poland.
Palka J; Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, Poland.
Bielawska K; Department of Analysis and Bioanalysis of Medicines, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, Poland.
Surazynski A; Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2022 Mar 30; Vol. 23 (7). Date of Electronic Publication: 2022 Mar 30.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*/drug therapy
Proline Oxidase*/genetics
Proline Oxidase*/metabolism
Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Apoptosis ; Cyclooxygenase 2/pharmacology ; Female ; Humans ; MCF-7 Cells ; Oxidoreductases ; Proline/metabolism ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruption.
Autorzy :
Zhang C; Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, United States.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Hu Z; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States.; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Lone AG; Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, United States.
Artami M; Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, United States.
Edwards M; Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, United States.
Zouboulis CC; Department of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodore Fontane and Faculty of Health Sciences Brandenburg, Dessau, Germany.
Stein M; Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, United States.
Harris-Tryon TA; Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, United States.; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States.
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Źródło :
ELife [Elife] 2022 Mar 02; Vol. 11. Date of Electronic Publication: 2022 Mar 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cornified Envelope Proline-Rich Proteins*
Methicillin-Resistant Staphylococcus aureus*
Animals ; Anti-Bacterial Agents ; Lipopolysaccharides ; Membrane Proteins/metabolism ; Mice ; Proline
Czasopismo naukowe
Tytuł :
Production of functional recombinant prolyl hydroxylase-2 enzyme in insect cells for small molecule inhibitor screening studies.
Autorzy :
Guo Z; School of Biotechnology, Tianjin University of Science and Technology, Key Lab of Industrial Fermentation Microbiology of the Ministry of Education, State Key Laboratory of Food Nutrition and Safety, Tianjin, 300457, China.
Zi J; School of Biotechnology, Tianjin University of Science and Technology, Key Lab of Industrial Fermentation Microbiology of the Ministry of Education, State Key Laboratory of Food Nutrition and Safety, Tianjin, 300457, China.
Hao Y; School of Biotechnology, Tianjin University of Science and Technology, Key Lab of Industrial Fermentation Microbiology of the Ministry of Education, State Key Laboratory of Food Nutrition and Safety, Tianjin, 300457, China.
Li Y; School of Biotechnology, Tianjin University of Science and Technology, Key Lab of Industrial Fermentation Microbiology of the Ministry of Education, State Key Laboratory of Food Nutrition and Safety, Tianjin, 300457, China.
Liu Z; School of Biotechnology, Tianjin University of Science and Technology, Key Lab of Industrial Fermentation Microbiology of the Ministry of Education, State Key Laboratory of Food Nutrition and Safety, Tianjin, 300457, China.
Zhao Q; School of Biotechnology, Tianjin University of Science and Technology, Key Lab of Industrial Fermentation Microbiology of the Ministry of Education, State Key Laboratory of Food Nutrition and Safety, Tianjin, 300457, China.
Hao L; School of Biotechnology, Tianjin University of Science and Technology, Key Lab of Industrial Fermentation Microbiology of the Ministry of Education, State Key Laboratory of Food Nutrition and Safety, Tianjin, 300457, China.
Diao A; School of Biotechnology, Tianjin University of Science and Technology, Key Lab of Industrial Fermentation Microbiology of the Ministry of Education, State Key Laboratory of Food Nutrition and Safety, Tianjin, 300457, China. Electronic address: .
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Źródło :
Protein expression and purification [Protein Expr Purif] 2022 Jun; Vol. 194, pp. 106073. Date of Electronic Publication: 2022 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Dioxygenases*
Hypoxia-Inducible Factor-Proline Dioxygenases*/genetics
Animals ; Humans ; Insecta/metabolism ; Procollagen-Proline Dioxygenase/metabolism ; Prolyl Hydroxylases/genetics ; Recombinant Proteins/genetics ; Recombinant Proteins/pharmacology
Czasopismo naukowe
Tytuł :
Nonsteroidal Anti-Inflammatory Drugs as PPARγ Agonists Can Induce PRODH/POX-Dependent Apoptosis in Breast Cancer Cells: New Alternative Pathway in NSAID-Induced Apoptosis.
Autorzy :
Kazberuk A; Department of Medicinal Chemistry, Medical University of Bialystok, 15-222 Bialystok, Poland.
Chalecka M; Department of Medicinal Chemistry, Medical University of Bialystok, 15-222 Bialystok, Poland.
Palka J; Department of Medicinal Chemistry, Medical University of Bialystok, 15-222 Bialystok, Poland.
Surazynski A; Department of Medicinal Chemistry, Medical University of Bialystok, 15-222 Bialystok, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 28; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 28.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Antineoplastic Agents/*pharmacology
Breast Neoplasms/*metabolism
PPAR gamma/*metabolism
Proline Oxidase/*metabolism
Apoptosis ; Breast Neoplasms/drug therapy ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Collagen/biosynthesis ; Collagen/drug effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; MCF-7 Cells ; Oxidative Phosphorylation/drug effects ; PPAR gamma/agonists ; Proline/metabolism ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Proline oxidase silencing inhibits p53-dependent apoptosis in MCF-7 breast cancer cells.
Autorzy :
Oscilowska I; Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland.
Huynh TYL; Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland.
Baszanowska W; Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland.
Prokop I; Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland.
Surazynski A; Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland.
Galli M; Department of Medical Biology, Medical University of Bialystok, Mickiewicza 2C, 15-222, Bialystok, Poland.
Zabielski P; Department of Medical Biology, Medical University of Bialystok, Mickiewicza 2C, 15-222, Bialystok, Poland.
Palka J; Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland. .
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Źródło :
Amino acids [Amino Acids] 2021 Dec; Vol. 53 (12), pp. 1943-1956. Date of Electronic Publication: 2021 Jun 04.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*genetics
Breast Neoplasms/*genetics
Proline Oxidase/*genetics
Tumor Suppressor Protein p53/*genetics
Cell Death/genetics ; Cell Line, Tumor ; Cell Survival/genetics ; Female ; Humans ; MCF-7 Cells ; Proline/genetics ; Proteomics/methods ; RNA, Small Interfering/genetics ; Reactive Oxygen Species/metabolism ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Psychiatric phenotypes associated with hyperprolinemia: A systematic review.
Autorzy :
Namavar Y; Department of Psychiatry and Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Psychiatry, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.
Duineveld DJ; Department of Psychiatry and Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Both GIA; Department of Psychiatry and Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Fiksinski AM; Department of Psychiatry and Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.; Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; The Dalglish Family 22q Clinic for 22q11.2 Deletion Syndrome, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
Vorstman JAS; Program in Genetics and Genome Biology, Research Institute, Toronto, Ontario, Canada.; Department of Psychiatry, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Verhoeven-Duif NM; Section of Metabolic Diagnostics, Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Zinkstok JR; Department of Psychiatry and Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
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Źródło :
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [Am J Med Genet B Neuropsychiatr Genet] 2021 Jul; Vol. 186 (5), pp. 289-317. Date of Electronic Publication: 2021 Jul 24.
Typ publikacji :
Journal Article; Review; Systematic Review
MeSH Terms :
Intellectual Disability*
Proline Oxidase*/genetics
Case-Control Studies ; Humans ; Phenotype ; Proline/genetics
Czasopismo naukowe
Tytuł :
Cortisol enhances citrulline synthesis from proline in enterocytes of suckling piglets.
Autorzy :
Dillon EL; Department of Animal Science and Faculty of Nutrition, Texas A&M University, College Station, TX, 77843-2471, USA.
Wu G; Department of Animal Science and Faculty of Nutrition, Texas A&M University, College Station, TX, 77843-2471, USA. .
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Źródło :
Amino acids [Amino Acids] 2021 Dec; Vol. 53 (12), pp. 1957-1966. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Citrulline/*metabolism
Enterocytes/*metabolism
Hydrocortisone/*metabolism
Proline/*metabolism
Animals ; Animals, Suckling/metabolism ; Arginine/metabolism ; Cell Proliferation/physiology ; Glutamine/metabolism ; Ileum/metabolism ; Jejunum/metabolism ; Male ; Proline Oxidase/metabolism ; Protein Biosynthesis/physiology ; Swine
Czasopismo naukowe
Tytuł :
Polyamine synthesis from arginine and proline in tissues of developing chickens.
Autorzy :
Furukawa K; Department of Animal Science, Texas A&M University, College Station, TX, 77843-2471, USA.; Animal Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai, 980-8572, Japan.; International Education and Research Center for Food and Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai, 980-8572, Japan.
He W; Department of Animal Science, Texas A&M University, College Station, TX, 77843-2471, USA.
Bailey CA; Department of Poultry Science, Texas A&M University, College Station, TX, 77843-2471, USA.
Bazer FW; Department of Animal Science, Texas A&M University, College Station, TX, 77843-2471, USA.
Toyomizu M; Animal Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai, 980-8572, Japan.; International Education and Research Center for Food and Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai, 980-8572, Japan.
Wu G; Department of Animal Science, Texas A&M University, College Station, TX, 77843-2471, USA. .
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Źródło :
Amino acids [Amino Acids] 2021 Nov; Vol. 53 (11), pp. 1739-1748. Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
Arginine/*metabolism
Chickens/*growth & development
Polyamines/*metabolism
Proline/*metabolism
Animals ; Chickens/metabolism ; Jejunum/growth & development ; Jejunum/metabolism ; Kidney/growth & development ; Kidney/metabolism ; Liver/growth & development ; Liver/metabolism ; Mitochondria/metabolism ; Muscle, Skeletal/growth & development ; Muscle, Skeletal/metabolism ; Ornithine Decarboxylase/metabolism ; Proline Oxidase/metabolism
Czasopismo naukowe
Tytuł :
Structural stability of antimicrobial peptides rich in tryptophan, proline and arginine: a computational study.
Autorzy :
Marimuthu SK; Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research, University College of Engineering, Anna University, Bharathidasan Institute of Technology (BIT) Campus, Tiruchirappalli, Tamilnadu, India.
Nagarajan K; Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research, University College of Engineering, Anna University, Bharathidasan Institute of Technology (BIT) Campus, Tiruchirappalli, Tamilnadu, India.
Perumal SK; Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research, University College of Engineering, Anna University, Bharathidasan Institute of Technology (BIT) Campus, Tiruchirappalli, Tamilnadu, India.
Palanisamy S; Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research, University College of Engineering, Anna University, Bharathidasan Institute of Technology (BIT) Campus, Tiruchirappalli, Tamilnadu, India.
Subbiah L; Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research, University College of Engineering, Anna University, Bharathidasan Institute of Technology (BIT) Campus, Tiruchirappalli, Tamilnadu, India.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2022 May; Vol. 40 (8), pp. 3551-3559. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
Proline*/chemistry
Tryptophan*/chemistry
Amino Acids ; Anti-Bacterial Agents/chemistry ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Peptides ; Arginine/chemistry
Czasopismo naukowe
Tytuł :
Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332.
Autorzy :
Li J; College of Pharmaceutical Sciences, Gannan Medical Universitygrid.440714.2, Ganzhou, China.
Lin C; School of Basic Medical Sciences, Nanchang Universitygrid.260463.5, Nanchang, China.
Zhou X; Shenzhen Crystalo Biopharmaceutical Co., Ltd., Shenzhen, China.; Jiangxi Jmerry Biopharmaceutical Co., Ltd., Ganzhou, China.
Zhong F; Shenzhen Crystalo Biopharmaceutical Co., Ltd., Shenzhen, China.; Jiangxi Jmerry Biopharmaceutical Co., Ltd., Ganzhou, China.
Zeng P; Shenzhen Crystalo Biopharmaceutical Co., Ltd., Shenzhen, China.; Jiangxi Jmerry Biopharmaceutical Co., Ltd., Ganzhou, China.
Yang Y; Shenzhen Crystalo Biopharmaceutical Co., Ltd., Shenzhen, China.
Zhang Y; School of Basic Medical Sciences, Nanchang Universitygrid.260463.5, Nanchang, China.
Yu B; School of Basic Medical Sciences, Nanchang Universitygrid.260463.5, Nanchang, China.
Fan X; College of Pharmaceutical Sciences, Gannan Medical Universitygrid.440714.2, Ganzhou, China.
McCormick PJ; William Harvey Research Institute, Bart's and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Fu R; Jiangxi Provincial Children's Hospital, Nanchang, China.
Fu Y; School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Jiang H; School of Basic Medical Sciences, Nanchang Universitygrid.260463.5, Nanchang, China.
Zhang J; School of Basic Medical Sciences, Nanchang Universitygrid.260463.5, Nanchang, China.
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Źródło :
Journal of virology [J Virol] 2022 Apr 27; Vol. 96 (8), pp. e0201321. Date of Electronic Publication: 2022 Apr 07.
Typ publikacji :
Journal Article
MeSH Terms :
Lactams*/chemistry
Lactams*/metabolism
Leucine*/chemistry
Leucine*/metabolism
Nitriles*/chemistry
Nitriles*/metabolism
Peptide Hydrolases*/chemistry
Peptide Hydrolases*/metabolism
Proline*/chemistry
Proline*/metabolism
Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; COVID-19/drug therapy ; Humans ; Middle East Respiratory Syndrome Coronavirus/chemistry ; Middle East Respiratory Syndrome Coronavirus/enzymology ; Protease Inhibitors/chemistry ; Protease Inhibitors/metabolism ; SARS Virus/chemistry ; SARS Virus/enzymology ; SARS-CoV-2/chemistry ; SARS-CoV-2/enzymology
Czasopismo naukowe
Tytuł :
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19.
Autorzy :
Hammond J; From Global Product Development, Pfizer, Collegeville, PA (J.H., H.L.-T.); Global Product Development (A.G.) and Early Clinical Development (M.L.B.), Pfizer, Cambridge, MA; Global Product Development, Pfizer, New York (P.A., W.B., B.D., R.P.); Global Product Development, Pfizer, Lake Forest, IL (W.W.); Medical and Safety, Pfizer, Sandwich, United Kingdom (V.M.H.); Köhler and Milstein Research, Mérida, Yucatan, Mexico (A.S.-C.); and Global Product Development, Pfizer, Tampa, FL (J.M.R.).
Leister-Tebbe H; From Global Product Development, Pfizer, Collegeville, PA (J.H., H.L.-T.); Global Product Development (A.G.) and Early Clinical Development (M.L.B.), Pfizer, Cambridge, MA; Global Product Development, Pfizer, New York (P.A., W.B., B.D., R.P.); Global Product Development, Pfizer, Lake Forest, IL (W.W.); Medical and Safety, Pfizer, Sandwich, United Kingdom (V.M.H.); Köhler and Milstein Research, Mérida, Yucatan, Mexico (A.S.-C.); and Global Product Development, Pfizer, Tampa, FL (J.M.R.).
Gardner A; From Global Product Development, Pfizer, Collegeville, PA (J.H., H.L.-T.); Global Product Development (A.G.) and Early Clinical Development (M.L.B.), Pfizer, Cambridge, MA; Global Product Development, Pfizer, New York (P.A., W.B., B.D., R.P.); Global Product Development, Pfizer, Lake Forest, IL (W.W.); Medical and Safety, Pfizer, Sandwich, United Kingdom (V.M.H.); Köhler and Milstein Research, Mérida, Yucatan, Mexico (A.S.-C.); and Global Product Development, Pfizer, Tampa, FL (J.M.R.).
Abreu P; From Global Product Development, Pfizer, Collegeville, PA (J.H., H.L.-T.); Global Product Development (A.G.) and Early Clinical Development (M.L.B.), Pfizer, Cambridge, MA; Global Product Development, Pfizer, New York (P.A., W.B., B.D., R.P.); Global Product Development, Pfizer, Lake Forest, IL (W.W.); Medical and Safety, Pfizer, Sandwich, United Kingdom (V.M.H.); Köhler and Milstein Research, Mérida, Yucatan, Mexico (A.S.-C.); and Global Product Development, Pfizer, Tampa, FL (J.M.R.).
Bao W; From Global Product Development, Pfizer, Collegeville, PA (J.H., H.L.-T.); Global Product Development (A.G.) and Early Clinical Development (M.L.B.), Pfizer, Cambridge, MA; Global Product Development, Pfizer, New York (P.A., W.B., B.D., R.P.); Global Product Development, Pfizer, Lake Forest, IL (W.W.); Medical and Safety, Pfizer, Sandwich, United Kingdom (V.M.H.); Köhler and Milstein Research, Mérida, Yucatan, Mexico (A.S.-C.); and Global Product Development, Pfizer, Tampa, FL (J.M.R.).
Wisemandle W; From Global Product Development, Pfizer, Collegeville, PA (J.H., H.L.-T.); Global Product Development (A.G.) and Early Clinical Development (M.L.B.), Pfizer, Cambridge, MA; Global Product Development, Pfizer, New York (P.A., W.B., B.D., R.P.); Global Product Development, Pfizer, Lake Forest, IL (W.W.); Medical and Safety, Pfizer, Sandwich, United Kingdom (V.M.H.); Köhler and Milstein Research, Mérida, Yucatan, Mexico (A.S.-C.); and Global Product Development, Pfizer, Tampa, FL (J.M.R.).
Baniecki M; From Global Product Development, Pfizer, Collegeville, PA (J.H., H.L.-T.); Global Product Development (A.G.) and Early Clinical Development (M.L.B.), Pfizer, Cambridge, MA; Global Product Development, Pfizer, New York (P.A., W.B., B.D., R.P.); Global Product Development, Pfizer, Lake Forest, IL (W.W.); Medical and Safety, Pfizer, Sandwich, United Kingdom (V.M.H.); Köhler and Milstein Research, Mérida, Yucatan, Mexico (A.S.-C.); and Global Product Development, Pfizer, Tampa, FL (J.M.R.).
Hendrick VM; From Global Product Development, Pfizer, Collegeville, PA (J.H., H.L.-T.); Global Product Development (A.G.) and Early Clinical Development (M.L.B.), Pfizer, Cambridge, MA; Global Product Development, Pfizer, New York (P.A., W.B., B.D., R.P.); Global Product Development, Pfizer, Lake Forest, IL (W.W.); Medical and Safety, Pfizer, Sandwich, United Kingdom (V.M.H.); Köhler and Milstein Research, Mérida, Yucatan, Mexico (A.S.-C.); and Global Product Development, Pfizer, Tampa, FL (J.M.R.).
Damle B; From Global Product Development, Pfizer, Collegeville, PA (J.H., H.L.-T.); Global Product Development (A.G.) and Early Clinical Development (M.L.B.), Pfizer, Cambridge, MA; Global Product Development, Pfizer, New York (P.A., W.B., B.D., R.P.); Global Product Development, Pfizer, Lake Forest, IL (W.W.); Medical and Safety, Pfizer, Sandwich, United Kingdom (V.M.H.); Köhler and Milstein Research, Mérida, Yucatan, Mexico (A.S.-C.); and Global Product Development, Pfizer, Tampa, FL (J.M.R.).
Simón-Campos A; From Global Product Development, Pfizer, Collegeville, PA (J.H., H.L.-T.); Global Product Development (A.G.) and Early Clinical Development (M.L.B.), Pfizer, Cambridge, MA; Global Product Development, Pfizer, New York (P.A., W.B., B.D., R.P.); Global Product Development, Pfizer, Lake Forest, IL (W.W.); Medical and Safety, Pfizer, Sandwich, United Kingdom (V.M.H.); Köhler and Milstein Research, Mérida, Yucatan, Mexico (A.S.-C.); and Global Product Development, Pfizer, Tampa, FL (J.M.R.).
Pypstra R; From Global Product Development, Pfizer, Collegeville, PA (J.H., H.L.-T.); Global Product Development (A.G.) and Early Clinical Development (M.L.B.), Pfizer, Cambridge, MA; Global Product Development, Pfizer, New York (P.A., W.B., B.D., R.P.); Global Product Development, Pfizer, Lake Forest, IL (W.W.); Medical and Safety, Pfizer, Sandwich, United Kingdom (V.M.H.); Köhler and Milstein Research, Mérida, Yucatan, Mexico (A.S.-C.); and Global Product Development, Pfizer, Tampa, FL (J.M.R.).
Rusnak JM; From Global Product Development, Pfizer, Collegeville, PA (J.H., H.L.-T.); Global Product Development (A.G.) and Early Clinical Development (M.L.B.), Pfizer, Cambridge, MA; Global Product Development, Pfizer, New York (P.A., W.B., B.D., R.P.); Global Product Development, Pfizer, Lake Forest, IL (W.W.); Medical and Safety, Pfizer, Sandwich, United Kingdom (V.M.H.); Köhler and Milstein Research, Mérida, Yucatan, Mexico (A.S.-C.); and Global Product Development, Pfizer, Tampa, FL (J.M.R.).
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Corporate Authors :
EPIC-HR Investigators
Źródło :
The New England journal of medicine [N Engl J Med] 2022 Apr 14; Vol. 386 (15), pp. 1397-1408. Date of Electronic Publication: 2022 Feb 16.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents*/administration & dosage
Antiviral Agents*/adverse effects
Antiviral Agents*/therapeutic use
COVID-19*/drug therapy
Lactams*/administration & dosage
Lactams*/adverse effects
Lactams*/therapeutic use
Leucine*/administration & dosage
Leucine*/adverse effects
Leucine*/therapeutic use
Nitriles*/administration & dosage
Nitriles*/adverse effects
Nitriles*/therapeutic use
Proline*/administration & dosage
Proline*/adverse effects
Proline*/therapeutic use
Ritonavir*/administration & dosage
Ritonavir*/adverse effects
Ritonavir*/therapeutic use
Administration, Oral ; Adult ; Disease Progression ; Double-Blind Method ; Hospitalization ; Humans ; SARS-CoV-2 ; Treatment Outcome ; Vaccination ; Viral Load/drug effects ; Viral Protease Inhibitors/administration & dosage ; Viral Protease Inhibitors/adverse effects ; Viral Protease Inhibitors/therapeutic use
Czasopismo naukowe
Tytuł :
Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia.
Autorzy :
Rosendahl AH; Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.
Monnius M; Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.
Laitala A; Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.
Railo A; Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.
Miinalainen I; Biocenter Oulu, Electron Microscope Core Facility, University of Oulu, Oulu, Finland.
Heljasvaara R; Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.
Mäki JM; Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland. Electronic address: .
Myllyharju J; Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2022 Apr; Vol. 298 (4), pp. 101787. Date of Electronic Publication: 2022 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Alopecia*/enzymology
Alopecia*/genetics
Hypoxia-Inducible Factor-Proline Dioxygenases*/genetics
Hypoxia-Inducible Factor-Proline Dioxygenases*/metabolism
Animals ; Mice ; Oxygen/metabolism ; Transforming Growth Factor beta
Czasopismo naukowe
Tytuł :
Structural basis of dynamic P5CS filaments.
Autorzy :
Zhong J; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Guo CJ; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Zhou X; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Chang CC; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Yin B; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Zhang T; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Hu HH; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Lu GM; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Liu JL; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
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Źródło :
ELife [Elife] 2022 Mar 14; Vol. 11. Date of Electronic Publication: 2022 Mar 14.
Typ publikacji :
Journal Article
MeSH Terms :
Ornithine-Oxo-Acid Transaminase*/genetics
Proline*
Cryoelectron Microscopy ; Cytoskeleton ; Mutation
Czasopismo naukowe
Tytuł :
SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation.
Autorzy :
Shen L; Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, United States.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
Yu Y; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
Zhou Y; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, United States.
Pruett-Miller SM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, United States.
Zhang GF; Sarah W. Stedman Nutrition and Metabolism Center & Duke Molecular Physiology Institute, Duke University Medical Center, Durham, United States.; Department of Medicine, Duke University School of Medicine, Durham, United States.
Karner CM; Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, United States.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.; Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center at Dallas, Dallas, United States.
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Źródło :
ELife [Elife] 2022 Mar 09; Vol. 11. Date of Electronic Publication: 2022 Mar 09.
Typ publikacji :
Journal Article
MeSH Terms :
Osteogenesis*
Proline*/metabolism
Animals ; Cell Differentiation ; Mice ; Osteoblasts/metabolism ; Proteins/metabolism
Czasopismo naukowe
Tytuł :
Proline, a multifaceted signalling molecule in plant responses to abiotic stress: understanding the physiological mechanisms.
Autorzy :
Ghosh UK; Department of Agronomy, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
Islam MN; Department of Agro-Processing, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
Siddiqui MN; Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.; Institute of Crop Science and Resource Conservation (INRES)-Plant Breeding and Biotechnology, University of Bonn, Bonn, Germany.
Cao X; School of Chemistry and Food Science, Yulin Normal University, Yulin, China.
Khan MAR; Department of Agronomy, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
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Źródło :
Plant biology (Stuttgart, Germany) [Plant Biol (Stuttg)] 2022 Mar; Vol. 24 (2), pp. 227-239. Date of Electronic Publication: 2021 Nov 18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Proline*/metabolism
Stress, Physiological*
Gene Expression Regulation, Plant ; Plant Development ; Plants, Genetically Modified/metabolism ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Activation of the hypoxia response pathway protects against age-induced cardiac hypertrophy.
Autorzy :
Röning T; Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland.
Magga J; Biocenter Oulu and Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Finland.
Laitakari A; Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland.
Halmetoja R; Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland.
Tapio J; Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland.
Dimova EY; Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland.
Szabo Z; Biocenter Oulu and Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Finland.
Rahtu-Korpela L; Biocenter Oulu and Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Finland.
Kemppi A; Biocenter Oulu and Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Finland.
Walkinshaw G; FibroGen Inc., San Francisco, CA, USA.
Myllyharju J; Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland.
Kerkelä R; Biocenter Oulu and Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Finland.
Koivunen P; Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland. Electronic address: .
Serpi R; Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland; Faculty of Medicine, University of Oulu, Oulu, Finland; Biobank Borealis of Northern Finland, Oulu University Hospital, Finland.
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2022 Mar; Vol. 164, pp. 148-155. Date of Electronic Publication: 2021 Dec 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hypoxia-Inducible Factor-Proline Dioxygenases*/genetics
Hypoxia-Inducible Factor-Proline Dioxygenases*/metabolism
Signal Transduction*
Animals ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cardiomegaly/genetics ; Hypoxia ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Mice ; Rats
Czasopismo naukowe
Tytuł :
Inactivation of HIF-prolyl 4-hydroxylases 1, 2 and 3 in NG2-expressing cells induces HIF2-mediated neurovascular expansion independent of erythropoietin.
Autorzy :
Urrutia AA; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.; Unidad de Investigación Hospital de Santa Cristina, Instituto de Investigación del Hospital Universitario La Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
Guan N; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.; Division of Nephrology, Huashan Hospital and Nephrology Research Institute, Fudan University, Shanghai, China.
Mesa-Ciller C; Unidad de Investigación Hospital de Santa Cristina, Instituto de Investigación del Hospital Universitario La Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
Afzal A; Department of Neurosurgery, Vanderbilt University School of Medicine, Nashville, TN, USA.
Davidoff O; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Haase VH; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.; Division of Integrative Physiology, Department of Medical Cell Biology, Uppsala Universitet, Uppsala, Sweden.; Department of Molecular Physiology and Biophysics and Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
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Źródło :
Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2021 Jan; Vol. 231 (1), pp. e13547. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Erythropoietin*
Hypoxia-Inducible Factor-Proline Dioxygenases*
Animals ; Hypoxia-Inducible Factor 1, alpha Subunit ; Mice ; Pericytes ; Procollagen-Proline Dioxygenase ; Prolyl Hydroxylases
Czasopismo naukowe
Tytuł :
N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties.
Autorzy :
Scott GK; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.
Mahoney S; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.
Scott M; Department of Medicine, Center for Biomedical Informatics, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Loureiro A; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.
Lopez-Ramirez A; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.
Tanner JJ; Department of Biochemistry, University of Missouri, Columbia, MO, 65211, USA.
Ellerby LM; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.
Benz CC; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA. .
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Źródło :
Amino acids [Amino Acids] 2021 Dec; Vol. 53 (12), pp. 1927-1939. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Alkynes/*pharmacology
Antineoplastic Agents/*pharmacology
Brain/*drug effects
Glycine/*analogs & derivatives
Proline/*metabolism
Proline Oxidase/*antagonists & inhibitors
ATPases Associated with Diverse Cellular Activities/metabolism ; Animals ; Blood-Retinal Barrier/drug effects ; Blood-Retinal Barrier/metabolism ; Brain/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; Glycine/pharmacology ; Humans ; Male ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondrial Proteins/metabolism ; Proline/analogs & derivatives ; Proline/pharmacology ; Thiazolidines/pharmacology ; Transcriptome/drug effects ; Unfolded Protein Response/drug effects
Czasopismo naukowe
Tytuł :
AMP-activated protein kinase α1 phosphorylates PHD2 to maintain systemic iron homeostasis.
Autorzy :
Wang C; Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Rheumatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhang W; Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xu W; Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Liu Z; Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Huang K; Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
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Źródło :
Clinical and translational medicine [Clin Transl Med] 2022 May; Vol. 12 (5), pp. e854.
Typ publikacji :
Journal Article
MeSH Terms :
AMP-Activated Protein Kinases*/metabolism
Hepcidins*/metabolism
Hypoxia-Inducible Factor-Proline Dioxygenases*/metabolism
Iron*/metabolism
Animals ; Homeostasis ; Humans ; Hypoxia/metabolism ; Mice
Czasopismo naukowe
Tytuł :
The complex vibrational spectrum of proline explained through the adiabatically switched semiclassical initial value representation.
Autorzy :
Botti G; Dipartimento di Chimica, Università degli Studi di Milano, via Golgi 19, 20133 Milano, Italy.
Aieta C; Dipartimento di Chimica, Università degli Studi di Milano, via Golgi 19, 20133 Milano, Italy.
Conte R; Dipartimento di Chimica, Università degli Studi di Milano, via Golgi 19, 20133 Milano, Italy.
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Źródło :
The Journal of chemical physics [J Chem Phys] 2022 Apr 28; Vol. 156 (16), pp. 164303.
Typ publikacji :
Journal Article
MeSH Terms :
Proline*
Vibration*
Czasopismo naukowe

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