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Tytuł:
PCDH17 gene promoter methylation status in a cohort of Egyptian women with epithelial ovarian cancer.
Autorzy:
Elsharkawi SM; Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. .
Elkaffash D; Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Moez P; Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
El-Etreby N; Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Sheta E; Department of Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Taleb RSZ; Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
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Źródło:
BMC cancer [BMC Cancer] 2023 Jan 25; Vol. 23 (1), pp. 89. Date of Electronic Publication: 2023 Jan 25.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Ovarian Epithelial*/genetics
DNA Methylation*
Ovarian Neoplasms*/genetics
Promoter Regions, Genetic*
Cadherins*/genetics
Female ; Humans ; Egypt ; Ovarian Cysts
Czasopismo naukowe
Szczegóły
Tytuł:
Enhanced myogenesis through lncFAM-mediated recruitment of HNRNPL to the MYBPC2 promoter.
Autorzy:
Chang MW; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Yang JH; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Tsitsipatis D; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Yang X; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Martindale JL; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Munk R; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Pandey PR; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Banskota N; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Romero B; Department of Medical and Molecular Sciences, University of Delaware, Newark, DE 19716, USA.
Batish M; Department of Medical and Molecular Sciences, University of Delaware, Newark, DE 19716, USA.
Piao Y; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Mazan-Mamczarz K; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
De S; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Abdelmohsen K; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Wilson GM; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Gorospe M; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2022 Dec 09; Vol. 50 (22), pp. 13026-13044.
Typ publikacji:
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms:
Heterogeneous-Nuclear Ribonucleoprotein L*/genetics
Heterogeneous-Nuclear Ribonucleoprotein L*/metabolism
Muscle Development*/genetics
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
Transcription, Genetic*/genetics
Promoter Regions, Genetic*
Humans ; Muscle Fibers, Skeletal/metabolism ; Myoblasts/cytology ; Myoblasts/metabolism ; Gene Silencing ; Protein Transport/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
Manipulation of topoisomerase expression inhibits cell division but not growth and reveals a distinctive promoter structure in Synechocystis.
Autorzy:
Behle A; Institut f. Synthetische Mikrobiologie, Heinrich-Heine Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.; Photanol B.V, Science Park 406, 1098 XH Amsterdam, The Netherlands.
Dietsch M; Institut f. Synthetische Mikrobiologie, Heinrich-Heine Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
Goldschmidt L; Institut f. Quantitative u. Theoretische Biologie, Heinrich-Heine Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
Murugathas W; Institut f. Synthetische Mikrobiologie, Heinrich-Heine Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
Berwanger LC; Institut f. Synthetische Mikrobiologie, Heinrich-Heine Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
Burmester J; Institut f. Synthetische Mikrobiologie, Heinrich-Heine Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
Yao L; School of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden.
Brandt D; Centrum für Biotechnologie (CeBiTec), Universität Bielefeld, Universitätsstrasse 27, 33615 Bielefeld, Germany.
Busche T; Centrum für Biotechnologie (CeBiTec), Universität Bielefeld, Universitätsstrasse 27, 33615 Bielefeld, Germany.
Kalinowski J; Centrum für Biotechnologie (CeBiTec), Universität Bielefeld, Universitätsstrasse 27, 33615 Bielefeld, Germany.
Hudson EP; School of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden.
Ebenhöh O; Institut f. Quantitative u. Theoretische Biologie, Heinrich-Heine Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.; Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany.
Axmann IM; Institut f. Synthetische Mikrobiologie, Heinrich-Heine Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
Machné R; Institut f. Synthetische Mikrobiologie, Heinrich-Heine Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.; Institut f. Quantitative u. Theoretische Biologie, Heinrich-Heine Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2022 Dec 09; Vol. 50 (22), pp. 12790-12808.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Promoter Regions, Genetic*/genetics
Synechocystis*/enzymology
Synechocystis*/genetics
DNA Topoisomerases*/genetics
DNA Topoisomerases*/metabolism
Cell Division/genetics ; Plasmids/genetics ; Transcriptional Activation ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Characterization of the promoter region of the murine Catsper2 gene.
Autorzy:
Contreras-Marciales ADP; Departamento de Genética y Biología Molecular, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Ciudad de México, Mexico.
López-Guzmán SF; Departamento de Genética y Biología Molecular, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Ciudad de México, Mexico.
Benítez-Hess ML; Departamento de Genética y Biología Molecular, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Ciudad de México, Mexico.
Oviedo N; Unidad de Investigación Médica en Inmunología e Infectología, Centro Médico Nacional, La Raza, Instituto Mexicano del Seguro Social, Ciudad de México, Mexico.
Hernández-Sánchez J; Departamento de Genética y Biología Molecular, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Ciudad de México, Mexico.
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Źródło:
FEBS open bio [FEBS Open Bio] 2022 Dec; Vol. 12 (12), pp. 2236-2249. Date of Electronic Publication: 2022 Nov 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium Channels*/genetics
Epigenesis, Genetic*
Promoter Regions, Genetic*
Seminal Plasma Proteins*/genetics
Animals ; Male ; Mice ; Binding Sites ; Gene Expression Regulation
Czasopismo naukowe
Szczegóły
Tytuł:
TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma.
Autorzy:
Chun-On P; Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy, and Critical Care Medicine, Pittsburgh, PA, USA.; Environmental and Occupational Health Department, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.; Faculty of Medicine and Public Health, Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand.
Hinchie AM; Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy, and Critical Care Medicine, Pittsburgh, PA, USA.
Beale HC; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, CA, USA.; Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA, USA.
Gil Silva AA; Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy, and Critical Care Medicine, Pittsburgh, PA, USA.
Rush E; University of Pittsburgh Medical Center, Hillman Cancer Institute, Pittsburgh, PA, USA.
Sander C; University of Pittsburgh Medical Center, Hillman Cancer Institute, Pittsburgh, PA, USA.
Connelly CJ; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Seynnaeve BKN; University of Pittsburgh Medical Center, Hillman Cancer Institute, Pittsburgh, PA, USA.; Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Kirkwood JM; University of Pittsburgh Medical Center, Hillman Cancer Institute, Pittsburgh, PA, USA.
Vaske OM; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, CA, USA.; Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA, USA.
Greider CW; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, CA, USA.; Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA, USA.; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alder JK; Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy, and Critical Care Medicine, Pittsburgh, PA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Nov 11; Vol. 378 (6620), pp. 664-668. Date of Electronic Publication: 2022 Nov 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Melanoma*/genetics
Promoter Regions, Genetic*/genetics
Shelterin Complex*/genetics
Skin Neoplasms*/genetics
Telomerase*/genetics
Telomere Homeostasis*/genetics
Telomere-Binding Proteins*/genetics
Humans ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Mutation ; Telomere/genetics ; Telomere/metabolism ; Transcriptional Activation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein ( Star ) Gene Expression in the Mouse Testis.
Autorzy:
Bouchard MF; Reproduction, Mother and Child Health, Centre de Recherche du CHU de Québec-Université Laval and Centre de Recherche en Reproduction, Développement et Santé Intergénérationnelle (CRDSI), Québec, QC GIV4G2, Canada.
Picard J; Reproduction, Mother and Child Health, Centre de Recherche du CHU de Québec-Université Laval and Centre de Recherche en Reproduction, Développement et Santé Intergénérationnelle (CRDSI), Québec, QC GIV4G2, Canada.
Tremblay JJ; Reproduction, Mother and Child Health, Centre de Recherche du CHU de Québec-Université Laval and Centre de Recherche en Reproduction, Développement et Santé Intergénérationnelle (CRDSI), Québec, QC GIV4G2, Canada.; Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec, QC G1K7P4, Canada.
Viger RS; Reproduction, Mother and Child Health, Centre de Recherche du CHU de Québec-Université Laval and Centre de Recherche en Reproduction, Développement et Santé Intergénérationnelle (CRDSI), Québec, QC GIV4G2, Canada.; Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec, QC G1K7P4, Canada.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Oct 09; Vol. 23 (19). Date of Electronic Publication: 2022 Oct 09.
Typ publikacji:
Journal Article
MeSH Terms:
Phosphoproteins*/genetics
Phosphoproteins*/metabolism
Promoter Regions, Genetic*
Sexual Maturation*
Testis*/metabolism
Animals ; Cholesterol/metabolism ; Gene Expression ; Leydig Cells/metabolism ; Male ; Mice ; RNA, Messenger/metabolism ; Steroids/metabolism ; Testosterone/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
AQP5-1364A/C Polymorphism Affects AQP5 Promoter Methylation.
Autorzy:
Rump K; Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Knappschaftskrankenhaus Bochum-Langendreer, 44892 Bochum, Germany.
Spellenberg T; Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Knappschaftskrankenhaus Bochum-Langendreer, 44892 Bochum, Germany.
von Busch A; Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Knappschaftskrankenhaus Bochum-Langendreer, 44892 Bochum, Germany.
Wolf A; Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Knappschaftskrankenhaus Bochum-Langendreer, 44892 Bochum, Germany.
Ziehe D; Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Knappschaftskrankenhaus Bochum-Langendreer, 44892 Bochum, Germany.
Thon P; Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Knappschaftskrankenhaus Bochum-Langendreer, 44892 Bochum, Germany.
Rahmel T; Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Knappschaftskrankenhaus Bochum-Langendreer, 44892 Bochum, Germany.
Adamzik M; Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Knappschaftskrankenhaus Bochum-Langendreer, 44892 Bochum, Germany.
Koos B; Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Knappschaftskrankenhaus Bochum-Langendreer, 44892 Bochum, Germany.
Unterberg M; Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Knappschaftskrankenhaus Bochum-Langendreer, 44892 Bochum, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Oct 05; Vol. 23 (19). Date of Electronic Publication: 2022 Oct 05.
Typ publikacji:
Journal Article
MeSH Terms:
Aquaporin 5*/genetics
Aquaporin 5*/metabolism
DNA Methylation*
Promoter Regions, Genetic*
Sepsis*/genetics
HL-60 Cells ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Association of lipid metabolism-related gene promoter methylation with risk of coronary artery disease.
Autorzy:
Li W; Department of Cardiovascular Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, 200127, Shanghai, China.
Wang Y; Department of Cardiovascular Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, 200127, Shanghai, China.
Huang R; Department of Cardiovascular Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, 200127, Shanghai, China.
Lian F; Department of Cardiovascular Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, 200127, Shanghai, China.
Xu G; Department of Cardiovascular Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, 200127, Shanghai, China.
Wang W; Department of Cardiovascular Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, 200127, Shanghai, China.
Xue S; Department of Cardiovascular Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, 200127, Shanghai, China. xuesong_.
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Źródło:
Molecular biology reports [Mol Biol Rep] 2022 Oct; Vol. 49 (10), pp. 9373-9378. Date of Electronic Publication: 2022 Aug 08.
Typ publikacji:
Journal Article
MeSH Terms:
Coronary Artery Disease*/genetics
DNA Methylation*/genetics
Genetic Predisposition to Disease*
Lipid Metabolism*/genetics
Promoter Regions, Genetic*
Apolipoprotein C-III/genetics ; Apolipoproteins B/genetics ; Female ; Humans ; Male ; Risk Factors
Czasopismo naukowe
Szczegóły
Tytuł:
Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer.
Autorzy:
Barger CJ; Department of Neurological Surgery, University of California, San Francisco, CA, USA.
Suwala AK; Department of Neurological Surgery, University of California, San Francisco, CA, USA.; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
Soczek KM; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
Wang AS; Department of Neurological Surgery, University of California, San Francisco, CA, USA.
Kim MY; Department of Neurological Surgery, University of California, San Francisco, CA, USA.
Hong C; Department of Neurological Surgery, University of California, San Francisco, CA, USA.
Doudna JA; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.; Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA, USA.; Department of Chemistry, University of California, Berkeley, CA, USA.; Molecular Biophysics & Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, CA, USA.
Chang SM; Department of Neurological Surgery, University of California, San Francisco, CA, USA.; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA.
Phillips JJ; Department of Neurological Surgery, University of California, San Francisco, CA, USA.; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, CA, USA.
Solomon DA; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, CA, USA.
Costello JF; Department of Neurological Surgery, University of California, San Francisco, CA, USA. .; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA. .
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Źródło:
Nature communications [Nat Commun] 2022 Sep 16; Vol. 13 (1), pp. 5430. Date of Electronic Publication: 2022 Sep 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Glioblastoma*/genetics
Promoter Regions, Genetic*/genetics
Telomerase*/genetics
Telomerase*/metabolism
Humans ; Mutation
Czasopismo naukowe
Szczegóły
Tytuł:
A mechanism for oxidative damage repair at gene regulatory elements.
Autorzy:
Ray S; School of Biosciences, University of Sheffield, Sheffield, UK.; The Healthy Lifespan and Neuroscience Institutes, University of Sheffield, Sheffield, UK.; School of Life and Environmental Sciences, Department of Life Sciences, University of Lincoln, Lincoln, UK.
Abugable AA; School of Biosciences, University of Sheffield, Sheffield, UK.; The Healthy Lifespan and Neuroscience Institutes, University of Sheffield, Sheffield, UK.
Parker J; School of Biosciences, University of Sheffield, Sheffield, UK.; Center for Advanced Parkinson Research, Harvard Medical School, Boston, MA, USA.
Liversidge K; School of Biosciences, University of Sheffield, Sheffield, UK.
Palminha NM; School of Biosciences, University of Sheffield, Sheffield, UK.; The Healthy Lifespan and Neuroscience Institutes, University of Sheffield, Sheffield, UK.
Liao C; School of Biosciences, University of Sheffield, Sheffield, UK.; The Healthy Lifespan and Neuroscience Institutes, University of Sheffield, Sheffield, UK.
Acosta-Martin AE; biOMICS Facility, Faculty of Science Mass Spectrometry Centre, University of Sheffield, Sheffield, UK.
Souza CDS; School of Biosciences, University of Sheffield, Sheffield, UK.; Sheffield Institute of Translational Neuroscience, University of Sheffield, Sheffield, UK.
Jurga M; Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, University of Bradford, Bradford, UK.
Sudbery I; School of Biosciences, University of Sheffield, Sheffield, UK.
El-Khamisy SF; School of Biosciences, University of Sheffield, Sheffield, UK. .; The Healthy Lifespan and Neuroscience Institutes, University of Sheffield, Sheffield, UK. .; Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, University of Bradford, Bradford, UK. .
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Źródło:
Nature [Nature] 2022 Sep; Vol. 609 (7929), pp. 1038-1047. Date of Electronic Publication: 2022 Sep 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Cycle Proteins*/metabolism
DNA Damage*
DNA Repair*
Oxidative Stress*/genetics
Promoter Regions, Genetic*/genetics
Chromatin/genetics ; Genes ; Genetic Complementation Test ; Mitosis ; Mutation ; Phosphoric Diester Hydrolases/metabolism ; Poly ADP Ribosylation ; RNA/biosynthesis ; RNA/genetics ; RNA Polymerase II/metabolism ; Spindle Apparatus/metabolism ; Transcription Initiation Site
Czasopismo naukowe
Szczegóły
Tytuł:
Structural Analysis of Ino2p/Ino4p Mutual Interactions and Their Binding Interface with Promoter DNA.
Autorzy:
Khan MH; Hefei National Laboratory for Physical Sciences at the Microscale, Division of Molecular and Cellular Biophysics, University of Science and Technology of China, Hefei 230026, China.; Division of Life Sciences and Medicine, School of Life Sciences, University of Science and Technology of China, Hefei 230026, China.
Xue L; Hefei National Laboratory for Physical Sciences at the Microscale, Division of Molecular and Cellular Biophysics, University of Science and Technology of China, Hefei 230026, China.; Division of Life Sciences and Medicine, School of Life Sciences, University of Science and Technology of China, Hefei 230026, China.
Yue J; Hefei National Laboratory for Physical Sciences at the Microscale, Division of Molecular and Cellular Biophysics, University of Science and Technology of China, Hefei 230026, China.; Division of Life Sciences and Medicine, School of Life Sciences, University of Science and Technology of China, Hefei 230026, China.
Schüller HJ; Institut für Genetik und Funktionelle Genomforschung, Felix-Hausdorff-Str. 8, 17487 Greifswald, Germany.
Zhu Z; Hefei National Laboratory for Physical Sciences at the Microscale, Division of Molecular and Cellular Biophysics, University of Science and Technology of China, Hefei 230026, China.; Division of Life Sciences and Medicine, School of Life Sciences, University of Science and Technology of China, Hefei 230026, China.
Niu L; Hefei National Laboratory for Physical Sciences at the Microscale, Division of Molecular and Cellular Biophysics, University of Science and Technology of China, Hefei 230026, China.; Division of Life Sciences and Medicine, School of Life Sciences, University of Science and Technology of China, Hefei 230026, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jul 09; Vol. 23 (14). Date of Electronic Publication: 2022 Jul 09.
Typ publikacji:
Journal Article
MeSH Terms:
Basic Helix-Loop-Helix Transcription Factors*/genetics
Basic Helix-Loop-Helix Transcription Factors*/metabolism
Gene Expression Regulation, Fungal*/genetics
Gene Expression Regulation, Fungal*/physiology
Promoter Regions, Genetic*/genetics
Promoter Regions, Genetic*/physiology
Saccharomyces cerevisiae Proteins*/genetics
Saccharomyces cerevisiae Proteins*/metabolism
Transcription Factors*/genetics
Transcription Factors*/metabolism
DNA/genetics ; DNA/metabolism ; Phospholipids/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions.
Autorzy:
Wang K; Department of Bioengineering, Rice University, Houston, TX 77005, USA.
Escobar M; Department of BioSciences, Rice University, Houston, TX 77005, USA.
Li J; Department of Bioengineering, Rice University, Houston, TX 77005, USA.
Mahata B; Department of Bioengineering, Rice University, Houston, TX 77005, USA.
Goell J; Department of Bioengineering, Rice University, Houston, TX 77005, USA.
Shah S; Department of Bioengineering, Rice University, Houston, TX 77005, USA.
Cluck M; Department of BioSciences, Rice University, Houston, TX 77005, USA.
Hilton IB; Department of Bioengineering, Rice University, Houston, TX 77005, USA.; Department of BioSciences, Rice University, Houston, TX 77005, USA.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2022 Aug 12; Vol. 50 (14), pp. 7842-7855.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
CRISPR-Cas Systems*/genetics
Enhancer Elements, Genetic*
Promoter Regions, Genetic*
Transcriptional Activation*
Epigenomics ; Gene Expression Regulation ; Humans ; Peptide Fragments ; RNA ; Sialoglycoproteins ; Transcription Factors/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
Enhancer-promoter communication: unraveling enhancer strength and positioning within a given topologically associating domain (TAD).
Autorzy:
Giaimo BD; Institute of Biochemistry, Justus-Liebig-University Giessen, Friedrichstrasse 24, 35392, Giessen, Germany. .
Borggrefe T; Institute of Biochemistry, Justus-Liebig-University Giessen, Friedrichstrasse 24, 35392, Giessen, Germany. .
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Źródło:
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2022 Aug 12; Vol. 7 (1), pp. 281. Date of Electronic Publication: 2022 Aug 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms:
Chromatin*
Promoter Regions, Genetic*/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
dPromoter-XGBoost: Detecting promoters and strength by combining multiple descriptors and feature selection using XGBoost.
Autorzy:
Li H; College of Information and Computer Engineering, Northeast Forestry University, Harbin, China; Yangtze Delta Region Institute, University of Electronic Science and Technology, Quzhou,China.
Shi L; Department of Spine Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Gao W; College of Information and Computer Engineering, Northeast Forestry University, Harbin, China.
Zhang Z; College of Information and Computer Engineering, Northeast Forestry University, Harbin, China.
Zhang L; School of Intelligent Manufacturing and Equipment, Shenzhen Institute of Information Technology, Shenzhen, China.
Zhao Y; College of Information and Computer Engineering, Northeast Forestry University, Harbin, China.
Wang G; College of Information and Computer Engineering, Northeast Forestry University, Harbin, China. Electronic address: .
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Źródło:
Methods (San Diego, Calif.) [Methods] 2022 Aug; Vol. 204, pp. 215-222. Date of Electronic Publication: 2022 Jan 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Promoter Regions, Genetic*
Base Sequence
Czasopismo naukowe
Szczegóły
Tytuł:
Characterization of divergent promoters PmaiA and Phyd from Gordonia: Co-expression and regulation by CRP.
Autorzy:
Jaishankar J; Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, New Delhi 110016, India.
Keshav A; Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, New Delhi 110016, India.
Jayaram B; Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, New Delhi 110016, India.
Chavan S; Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, New Delhi 110016, India.
Srivastava P; Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, New Delhi 110016, India. Electronic address: .
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Źródło:
Biochimica et biophysica acta. Gene regulatory mechanisms [Biochim Biophys Acta Gene Regul Mech] 2022 Aug; Vol. 1865 (6), pp. 194843. Date of Electronic Publication: 2022 Jul 14.
Typ publikacji:
Journal Article
MeSH Terms:
Promoter Regions, Genetic*
Regulatory Sequences, Nucleic Acid*
Actinobacteria/*genetics
5' Untranslated Regions ; Base Sequence ; Binding Sites/genetics ; Escherichia coli/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
Coming full circle: On the origin and evolution of the looping model for enhancer-promoter communication.
Autorzy:
Popay TM; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA.
Dixon JR; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2022 Aug; Vol. 298 (8), pp. 102117. Date of Electronic Publication: 2022 Jun 09.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural
MeSH Terms:
Chromatin*/genetics
Enhancer Elements, Genetic*
Promoter Regions, Genetic*
Animals ; CCCTC-Binding Factor/genetics ; CCCTC-Binding Factor/metabolism ; Chromatin Assembly and Disassembly ; Mammals
Czasopismo naukowe
Szczegóły
Tytuł:
Quantitative parameters of bacterial RNA polymerase open-complex formation, stabilization and disruption on a consensus promoter.
Autorzy:
Bera SC; Junior Research Group 2, Interdisciplinary Center for Clinical Research, Friedrich Alexander University Erlangen-Nürnberg (FAU), Cauerstr. 3, 91058 Erlangen, Germany.
America PPB; Department of Physics and Astronomy, and LaserLaB Amsterdam, Vrije Universiteit Amsterdam, De Boelelaan 1081, 1081 HV, Amsterdam, The Netherlands.
Maatsola S; Department of Life Technologies, University of Turku, Tykistökatu 6A, 6th floor, 20520 Turku, Finland.
Seifert M; Junior Research Group 2, Interdisciplinary Center for Clinical Research, Friedrich Alexander University Erlangen-Nürnberg (FAU), Cauerstr. 3, 91058 Erlangen, Germany.
Ostrofet E; Junior Research Group 2, Interdisciplinary Center for Clinical Research, Friedrich Alexander University Erlangen-Nürnberg (FAU), Cauerstr. 3, 91058 Erlangen, Germany.
Cnossen J; Delft Center for Systems and Control, Delft University of Technology, Delft, the Netherlands.
Spermann M; Junior Research Group 2, Interdisciplinary Center for Clinical Research, Friedrich Alexander University Erlangen-Nürnberg (FAU), Cauerstr. 3, 91058 Erlangen, Germany.
Papini FS; Junior Research Group 2, Interdisciplinary Center for Clinical Research, Friedrich Alexander University Erlangen-Nürnberg (FAU), Cauerstr. 3, 91058 Erlangen, Germany.
Depken M; Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands.
Malinen AM; Department of Life Technologies, University of Turku, Tykistökatu 6A, 6th floor, 20520 Turku, Finland.
Dulin D; Junior Research Group 2, Interdisciplinary Center for Clinical Research, Friedrich Alexander University Erlangen-Nürnberg (FAU), Cauerstr. 3, 91058 Erlangen, Germany.; Department of Physics and Astronomy, and LaserLaB Amsterdam, Vrije Universiteit Amsterdam, De Boelelaan 1081, 1081 HV, Amsterdam, The Netherlands.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2022 Jul 22; Vol. 50 (13), pp. 7511-7528.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA-Directed RNA Polymerases*/genetics
DNA-Directed RNA Polymerases*/metabolism
Escherichia coli*/enzymology
Escherichia coli*/metabolism
Promoter Regions, Genetic*
Bacteria/genetics ; DNA, Bacterial/genetics ; DNA, Bacterial/metabolism ; Holoenzymes/genetics ; Holoenzymes/metabolism ; RNA, Bacterial ; Sigma Factor/metabolism ; Transcription, Genetic
Czasopismo naukowe
Szczegóły
Tytuł:
Quantitative contribution of the spacer length in the supercoiling-sensitivity of bacterial promoters.
Autorzy:
Forquet R; Université de Lyon, INSA Lyon, Université Claude Bernard Lyon 1, CNRS, UMR5240 MAP, F-69622, France.
Nasser W; Université de Lyon, INSA Lyon, Université Claude Bernard Lyon 1, CNRS, UMR5240 MAP, F-69622, France.
Reverchon S; Université de Lyon, INSA Lyon, Université Claude Bernard Lyon 1, CNRS, UMR5240 MAP, F-69622, France.
Meyer S; Université de Lyon, INSA Lyon, Université Claude Bernard Lyon 1, CNRS, UMR5240 MAP, F-69622, France.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2022 Jul 22; Vol. 50 (13), pp. 7287-7297.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA, Bacterial*/metabolism
DNA, Superhelical*/genetics
Promoter Regions, Genetic*
Transcription, Genetic*
Escherichia coli/genetics ; Escherichia coli/metabolism ; Nucleotides
Czasopismo naukowe
Szczegóły
Tytuł:
Systematic analysis of intrinsic enhancer-promoter compatibility in the mouse genome.
Autorzy:
Martinez-Ara M; Division of Gene Regulation and Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
Comoglio F; Division of Gene Regulation and Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
van Arensbergen J; Division of Gene Regulation and Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
van Steensel B; Division of Gene Regulation and Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2022 Jul 07; Vol. 82 (13), pp. 2519-2531.e6. Date of Electronic Publication: 2022 Apr 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Enhancer Elements, Genetic*/genetics
Genome*/genetics
Promoter Regions, Genetic*/genetics
Transcription Factors*/genetics
Transcription Factors*/metabolism
Animals ; Gene Expression Regulation ; Genomics ; Mammals/metabolism ; Mice ; Regulatory Sequences, Nucleic Acid/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
Compatibility rules of human enhancer and promoter sequences.
Autorzy:
Bergman DT; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Jones TR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Liu V; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Ray J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jagoda E; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Siraj L; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Biophysics Graduate Program, Harvard University, Cambridge, MA, USA.
Kang HY; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; BASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA.
Nasser J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Kane M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Rios A; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Nguyen TH; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Grossman SR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Fulco CP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Bristol Myers Squibb, Cambridge, MA, USA.
Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, MIT, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
Engreitz JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA. .; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. .; BASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA. .
Pokaż więcej
Źródło:
Nature [Nature] 2022 Jul; Vol. 607 (7917), pp. 176-184. Date of Electronic Publication: 2022 May 20.
Typ publikacji:
Journal Article
MeSH Terms:
Enhancer Elements, Genetic*/genetics
Promoter Regions, Genetic*/genetics
Humans ; RNA/biosynthesis ; RNA/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 69410

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