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Wyszukujesz frazę ""Promoter Regions, Genetic"" wg kryterium: Temat


Tytuł:
Enhancer-promoter interactions can form independently of genomic distance and be functional across TAD boundaries.
Autorzy:
Balasubramanian D; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique UMR5242, Université Claude Bernard-Lyon 1; 69364 Lyon, France.; Indian Institute of Science Education and Research (IISER) Tirupati; Tirupati 517507 Andhra Pradesh, India.
Borges Pinto P; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique UMR5242, Université Claude Bernard-Lyon 1; 69364 Lyon, France.
Grasso A; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique UMR5242, Université Claude Bernard-Lyon 1; 69364 Lyon, France.
Vincent S; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique UMR5242, Université Claude Bernard-Lyon 1; 69364 Lyon, France.
Tarayre H; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique UMR5242, Université Claude Bernard-Lyon 1; 69364 Lyon, France.
Lajoignie D; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique UMR5242, Université Claude Bernard-Lyon 1; 69364 Lyon, France.
Ghavi-Helm Y; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique UMR5242, Université Claude Bernard-Lyon 1; 69364 Lyon, France.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2024 Feb 28; Vol. 52 (4), pp. 1702-1719.
Typ publikacji:
Journal Article
MeSH Terms:
Chromatin*
Enhancer Elements, Genetic*
Promoter Regions, Genetic*
Animals ; Drosophila/cytology ; Drosophila/genetics ; Embryo, Nonmammalian/cytology ; Genomics ; Twist-Related Protein 1/genetics
Czasopismo naukowe
Tytuł:
Integrative Epigenetic and Molecular Analysis Reveals a Novel Promoter for a New Isoform of the Transcription Factor TEAD4.
Autorzy:
Rashidiani S; Institute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, 7624 Pécs, Hungary.
Mamo G; Institute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, 7624 Pécs, Hungary.
Farkas B; Institute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, 7624 Pécs, Hungary.
Szabadi A; Institute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, 7624 Pécs, Hungary.; Department of Dentistry, Oral and Maxillofacial Surgery, Medical School, University of Pécs, 7623 Pécs, Hungary.
Farkas B; Department of Obstetrics and Gynecology, Medical School, University of Pécs, 7624 Pécs, Hungary.; National Laboratory of Human Reproduction, University of Pécs, 7624 Pécs, Hungary.
Uszkai V; Department of Obstetrics and Gynecology, Medical School, University of Pécs, 7624 Pécs, Hungary.
Császár A; Department of Obstetrics and Gynecology, Medical School, University of Pécs, 7624 Pécs, Hungary.
Brandt B; Department of Medical Biology and Central Electron Microscope Laboratory, Medical School, University of Pécs, 7624 Pécs, Hungary.
Kovács K; Department of Obstetrics and Gynecology, Medical School, University of Pécs, 7624 Pécs, Hungary.; National Laboratory of Human Reproduction, University of Pécs, 7624 Pécs, Hungary.
Pap M; Department of Medical Biology and Central Electron Microscope Laboratory, Medical School, University of Pécs, 7624 Pécs, Hungary.
Rauch TA; Institute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, 7624 Pécs, Hungary.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 13; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 13.
Typ publikacji:
Journal Article
MeSH Terms:
DNA-Binding Proteins*/metabolism
TEA Domain Transcription Factors*/genetics
Transcription Factors*/metabolism
Promoter Regions, Genetic*
Female ; Humans ; Pregnancy ; DNA ; Epigenesis, Genetic ; Protein Isoforms/genetics ; Protein Isoforms/metabolism
Czasopismo naukowe
Tytuł:
Mutual promotion of co-condensation of KRAS G-quadruplex and a well-folded protein HMGB1.
Autorzy:
Wang Y; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230001, China.
Cao K; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230001, China.
Zong M; School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Yuan S; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230001, China.
Zhang N; High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, China.
Liu Y; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230001, China.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2024 Jan 11; Vol. 52 (1), pp. 288-299.
Typ publikacji:
Journal Article
MeSH Terms:
G-Quadruplexes*
HMGB1 Protein*/chemistry
HMGB1 Protein*/metabolism
Promoter Regions, Genetic*
Proto-Oncogene Proteins p21(ras)*/genetics
DNA/genetics ; DNA/chemistry ; Humans ; Phase Separation
Czasopismo naukowe
Tytuł:
PlantPAN 4.0: updated database for identifying conserved non-coding sequences and exploring dynamic transcriptional regulation in plant promoters.
Autorzy:
Chow CN; Institute of Tropical Plant Sciences and Microbiology, College of Biosciences and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan.; School of Molecular Sciences, Arizona State University, Tempe 85281, USA.
Yang CW; Institute of Tropical Plant Sciences and Microbiology, College of Biosciences and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan.
Wu NY; Institute of Tropical Plant Sciences and Microbiology, College of Biosciences and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan.
Wang HT; Institute of Tropical Plant Sciences and Microbiology, College of Biosciences and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan.
Tseng KC; Department of Life Sciences, National Cheng Kung University, Tainan 701, Taiwan.
Chiu YH; Graduate Program in Translational Agricultural Sciences, National Cheng Kung University and Academia Sinica, Tainan 701, Taiwan.
Lee TY; Department of Biological Science & Technology, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.
Chang WC; Institute of Tropical Plant Sciences and Microbiology, College of Biosciences and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan.; Department of Life Sciences, National Cheng Kung University, Tainan 701, Taiwan.; Graduate Program in Translational Agricultural Sciences, National Cheng Kung University and Academia Sinica, Tainan 701, Taiwan.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2024 Jan 05; Vol. 52 (D1), pp. D1569-D1578.
Typ publikacji:
Journal Article
MeSH Terms:
Databases, Genetic*
Gene Expression Regulation, Plant*
Plants*/genetics
Promoter Regions, Genetic*
Gene Regulatory Networks ; Protein Binding
Czasopismo naukowe
Tytuł:
Structures of the promoter-bound respiratory syncytial virus polymerase.
Autorzy:
Cao D; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Gao Y; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Chen Z; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Gooneratne I; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Roesler C; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Mera C; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
D'Cunha P; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Antonova A; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Katta D; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Romanelli S; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Wang Q; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Rice S; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Lemons W; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Ramanathan A; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Liang B; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA. .
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Źródło:
Nature [Nature] 2024 Jan; Vol. 625 (7995), pp. 611-617. Date of Electronic Publication: 2023 Dec 20.
Typ publikacji:
Journal Article
MeSH Terms:
Promoter Regions, Genetic*/genetics
Respiratory Syncytial Virus, Human*/enzymology
Respiratory Syncytial Virus, Human*/genetics
RNA-Dependent RNA Polymerase*/chemistry
RNA-Dependent RNA Polymerase*/metabolism
RNA-Dependent RNA Polymerase*/ultrastructure
RNA, Viral/biosynthesis ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Virus Replication/genetics ; Cryoelectron Microscopy ; Subgenomic RNA/biosynthesis ; Subgenomic RNA/genetics ; Subgenomic RNA/metabolism
Czasopismo naukowe
Tytuł:
Comparative Genetic Analysis of the Promoters of the ATG16L1 and ATG5 Genes Associated with Sporadic Parkinson's Disease.
Autorzy:
Gómez-Martín A; Nursing Department, Faculty of Nursing and Occupational Therapy, University of Extremadura, Avda de la Universidad s/n, 10003 Cáceres, Spain.; Instituto de Investigación Biosanitaria de Extremadura (INUBE), 10003 Cáceres, Spain.
Fuentes JM; Instituto de Investigación Biosanitaria de Extremadura (INUBE), 10003 Cáceres, Spain.; Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupa-cional, Universidad de Extremadura, 10003 Cáceres, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativa, Instituto de Salus Carlos III (CIBER-CIBERNED-ISCIII), 28029 Madrid, Spain.
Jordán J; Pharmacology, Medical Sciences Department, Albacete School of Medicine, University of Castilla-La Mancha, 02008 Albacete, Spain.
Galindo MF; Pharmaceutical Technologic, Medical Sciences Department, Albacete School of Pharmacy, University of Castilla-La Mancha, 02008 Albacete, Spain.
Fernández-García JL; Animal Production and Food Science Department, Faculty of Veterinary Sciences, University of Extremadura, Avda. de la Universidad, s/n, 10003 Caceres, Spain.
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Źródło:
Genes [Genes (Basel)] 2023 Dec 02; Vol. 14 (12). Date of Electronic Publication: 2023 Dec 02.
Typ publikacji:
Journal Article
MeSH Terms:
Genetic Predisposition to Disease*
Parkinson Disease*/genetics
Promoter Regions, Genetic*
Humans ; Autophagy-Related Protein 5/genetics ; Autophagy-Related Proteins/genetics ; Genotype ; Haplotypes
Czasopismo naukowe
Tytuł:
YY1 Binding to Regulatory Elements That Lack Enhancer Activity Promotes Locus Folding and Gene Activation.
Autorzy:
Gao Z; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.
Wang M; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.
Smith A; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.
Boyes J; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK. Electronic address: .
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Źródło:
Journal of molecular biology [J Mol Biol] 2023 Dec 01; Vol. 435 (23), pp. 168315. Date of Electronic Publication: 2023 Oct 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Promoter Regions, Genetic*/genetics
Transcriptional Activation*
YY1 Transcription Factor*/chemistry
YY1 Transcription Factor*/genetics
Animals ; Mice ; Binding Sites/genetics ; Chromatin/genetics ; Enhancer Elements, Genetic/genetics ; Genome-Wide Association Study ; Embryonic Stem Cells
Czasopismo naukowe
Tytuł:
Systematic sequence engineering enhances the induction strength of the glucose-regulated GTH1 promoter of Komagataella phaffii.
Autorzy:
Flores-Villegas M; CD-Laboratory for Growth-decoupled Protein Production in Yeast at Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU), Vienna, Austria.; University of Natural Resources and Life Sciences Vienna (BOKU), Department of Biotechnology, Institute of Microbiology and Microbial Biotechnology, Muthgasse 18, 1190 Vienna, Austria.
Rebnegger C; CD-Laboratory for Growth-decoupled Protein Production in Yeast at Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU), Vienna, Austria.; University of Natural Resources and Life Sciences Vienna (BOKU), Department of Biotechnology, Institute of Microbiology and Microbial Biotechnology, Muthgasse 18, 1190 Vienna, Austria.; ACIB GmbH, Muthgasse 11, 1190 Vienna, Austria.
Kowarz V; CD-Laboratory for Growth-decoupled Protein Production in Yeast at Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU), Vienna, Austria.; University of Natural Resources and Life Sciences Vienna (BOKU), Department of Biotechnology, Institute of Microbiology and Microbial Biotechnology, Muthgasse 18, 1190 Vienna, Austria.
Prielhofer R; University of Natural Resources and Life Sciences Vienna (BOKU), Department of Biotechnology, Institute of Microbiology and Microbial Biotechnology, Muthgasse 18, 1190 Vienna, Austria.
Mattanovich D; CD-Laboratory for Growth-decoupled Protein Production in Yeast at Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU), Vienna, Austria.; University of Natural Resources and Life Sciences Vienna (BOKU), Department of Biotechnology, Institute of Microbiology and Microbial Biotechnology, Muthgasse 18, 1190 Vienna, Austria.; ACIB GmbH, Muthgasse 11, 1190 Vienna, Austria.
Gasser B; CD-Laboratory for Growth-decoupled Protein Production in Yeast at Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU), Vienna, Austria.; University of Natural Resources and Life Sciences Vienna (BOKU), Department of Biotechnology, Institute of Microbiology and Microbial Biotechnology, Muthgasse 18, 1190 Vienna, Austria.; ACIB GmbH, Muthgasse 11, 1190 Vienna, Austria.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2023 Nov 10; Vol. 51 (20), pp. 11358-11374.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Glucose*/metabolism
Saccharomycetales*/genetics
Saccharomycetales*/metabolism
Promoter Regions, Genetic*
Glycerol/metabolism ; Nucleotides/metabolism ; Recombinant Proteins/metabolism
SCR Organism:
Komagataella phaffii
Czasopismo naukowe
Tytuł:
PD-L1 ( CD274 ) promoter hypomethylation predicts immunotherapy response in metastatic urothelial carcinoma.
Autorzy:
Klümper N; Department of Urology and Pediatric Urology, University Medical Center Bonn (UKB), Bonn, Germany.; Institute of Experimental Oncology, University Medical Center Bonn (UKB), Bonn, Germany.; Center for Integrated Oncology, Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Germany.
Wüst L; Center for Integrated Oncology, Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Germany.; Department of Otorhinolaryngology, University Medical Center Bonn (UKB), Bonn, Germany.
Saal J; Center for Integrated Oncology, Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Germany.; Medical Clinic III for Oncology, Hematology, Immune-Oncology and Rheumatology, University Medical Center Bonn (UKB), Bonn, Germany.
Ralser DJ; Institute of Experimental Oncology, University Medical Center Bonn (UKB), Bonn, Germany.; Center for Integrated Oncology, Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Germany.; Department of Gynaecology and Gynaecological Oncology, University Medical Center Bonn (UKB), Bonn, Germany.
Zarbl R; Center for Integrated Oncology, Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Germany.; Department of Otorhinolaryngology, University Medical Center Bonn (UKB), Bonn, Germany.
Jarczyk J; Department of Urology and Urosurgery, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Breyer J; Department of Urology, Caritas Hospital St. Josef, University of Regensburg, Regensburg, Germany.; Center for Integrated Oncology, Bavarian Center for Cancer Research (Bayerisches Zentrum für Krebsforschung, BZKF), Erlangen, Germany.
Sikic D; Center for Integrated Oncology, Bavarian Center for Cancer Research (Bayerisches Zentrum für Krebsforschung, BZKF), Erlangen, Germany.; Center for Integrated Oncology, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany.; Department of Urology and Pediatric Urology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Wullich B; Center for Integrated Oncology, Bavarian Center for Cancer Research (Bayerisches Zentrum für Krebsforschung, BZKF), Erlangen, Germany.; Center for Integrated Oncology, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany.; Department of Urology and Pediatric Urology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Bolenz C; Department of Urology, University Hospital Ulm, Ulm, Germany.
Roghmann F; Department of Urology, Ruhr-University Bochum, Herne, Germany.
Hölzel M; Institute of Experimental Oncology, University Medical Center Bonn (UKB), Bonn, Germany.; Center for Integrated Oncology, Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Germany.
Ritter M; Department of Urology and Pediatric Urology, University Medical Center Bonn (UKB), Bonn, Germany.; Center for Integrated Oncology, Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Germany.
Strieth S; Center for Integrated Oncology, Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Germany.; Department of Otorhinolaryngology, University Medical Center Bonn (UKB), Bonn, Germany.
Hartmann A; Center for Integrated Oncology, Bavarian Center for Cancer Research (Bayerisches Zentrum für Krebsforschung, BZKF), Erlangen, Germany.; Center for Integrated Oncology, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany.; Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.; Comprehensive Cancer Center EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Erben P; Department of Urology and Urosurgery, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Wirtz RM; Center for Integrated Oncology, STRATIFYER Molecular Pathology GmbH, Cologne, Germany.
Landsberg J; Center for Integrated Oncology, Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Germany.; Department of Dermatology and Allergy, University Medical Center Bonn (UKB), Bonn, Germany.
Dietrich D; Center for Integrated Oncology, Aachen/Bonn/Cologne/Düsseldorf (CIO-ABCD), Germany.; Department of Otorhinolaryngology, University Medical Center Bonn (UKB), Bonn, Germany.
Eckstein M; Center for Integrated Oncology, Bavarian Center for Cancer Research (Bayerisches Zentrum für Krebsforschung, BZKF), Erlangen, Germany.; Center for Integrated Oncology, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany.; Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.; Comprehensive Cancer Center EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
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Źródło:
Oncoimmunology [Oncoimmunology] 2023 Oct 19; Vol. 12 (1), pp. 2267744. Date of Electronic Publication: 2023 Oct 19 (Print Publication: 2023).
Typ publikacji:
Multicenter Study; Journal Article
MeSH Terms:
Carcinoma, Transitional Cell*/drug therapy
Carcinoma, Transitional Cell*/genetics
Immunotherapy*
Urinary Bladder Neoplasms*/drug therapy
Urinary Bladder Neoplasms*/genetics
Promoter Regions, Genetic*
Humans ; B7-H1 Antigen/genetics ; Interferon-gamma/genetics ; DNA Methylation
Czasopismo naukowe
Tytuł:
R-loop-dependent promoter-proximal termination ensures genome stability.
Autorzy:
Xu C; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Medical Epigenetics, Shanghai Key Laboratory of Radiation Oncology, Human Phenome Institute, Fudan University, Shanghai, China.
Li C; Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Chen J; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Medical Epigenetics, Shanghai Key Laboratory of Radiation Oncology, Human Phenome Institute, Fudan University, Shanghai, China.
Xiong Y; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Medical Epigenetics, Shanghai Key Laboratory of Radiation Oncology, Human Phenome Institute, Fudan University, Shanghai, China.
Qiao Z; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Medical Epigenetics, Shanghai Key Laboratory of Radiation Oncology, Human Phenome Institute, Fudan University, Shanghai, China.; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.
Fan P; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Medical Epigenetics, Shanghai Key Laboratory of Radiation Oncology, Human Phenome Institute, Fudan University, Shanghai, China.; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Li C; Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Ma S; Department of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liu J; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Medical Epigenetics, Shanghai Key Laboratory of Radiation Oncology, Human Phenome Institute, Fudan University, Shanghai, China.
Song A; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Medical Epigenetics, Shanghai Key Laboratory of Radiation Oncology, Human Phenome Institute, Fudan University, Shanghai, China.
Tao B; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Medical Epigenetics, Shanghai Key Laboratory of Radiation Oncology, Human Phenome Institute, Fudan University, Shanghai, China.
Xu T; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China.
Xu W; Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Chi Y; Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Xue J; Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Wang P; Huashan Hospital, Fudan University, Shanghai Key Laboratory of Medical Epigenetics, Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Shanghai Medical College of Fudan University, Shanghai, China.
Ye D; Huashan Hospital, Fudan University, Shanghai Key Laboratory of Medical Epigenetics, Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Shanghai Medical College of Fudan University, Shanghai, China.
Gu H; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Medical Epigenetics, Shanghai Key Laboratory of Radiation Oncology, Human Phenome Institute, Fudan University, Shanghai, China.
Zhang P; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Wang Q; Department of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiao R; Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Cheng J; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Medical Epigenetics, Shanghai Key Laboratory of Radiation Oncology, Human Phenome Institute, Fudan University, Shanghai, China.
Zheng H; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Medical Epigenetics, Shanghai Key Laboratory of Radiation Oncology, Human Phenome Institute, Fudan University, Shanghai, China.
Yu X; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.
Zhang Z; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.
Wu J; Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Liang K; Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Liu YJ; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Medical Epigenetics, Shanghai Key Laboratory of Radiation Oncology, Human Phenome Institute, Fudan University, Shanghai, China.
Lu H; Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China. huasong_.
Chen FX; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Medical Epigenetics, Shanghai Key Laboratory of Radiation Oncology, Human Phenome Institute, Fudan University, Shanghai, China. .; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China. .
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Źródło:
Nature [Nature] 2023 Sep; Vol. 621 (7979), pp. 610-619. Date of Electronic Publication: 2023 Aug 09.
Typ publikacji:
Journal Article
MeSH Terms:
Genomic Instability*/genetics
R-Loop Structures*/genetics
Promoter Regions, Genetic*/genetics
Transcription Termination, Genetic*
Humans ; DNA, Single-Stranded/metabolism ; Mutation ; RNA Polymerase II/metabolism ; Genome, Human ; DNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł:
Flipons and small RNAs accentuate the asymmetries of pervasive transcription by the reset and sequence-specific microcoding of promoter conformation.
Autorzy:
Herbert A; Discovery Division, InsideOutBio, Charlestown, Massachusetts, USA. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Sep; Vol. 299 (9), pp. 105140. Date of Electronic Publication: 2023 Aug 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
DNA*/chemistry
DNA*/genetics
DNA*/metabolism
Nucleic Acid Conformation*
Promoter Regions, Genetic*/genetics
RNA*/genetics
Transcription, Genetic*
Animals ; DNA, Single-Stranded/chemistry ; DNA, Single-Stranded/genetics ; DNA, Single-Stranded/metabolism ; DNA, Z-Form/chemistry ; DNA, Z-Form/genetics ; DNA, Z-Form/metabolism ; Epigenesis, Genetic ; Genome/genetics ; Histones/metabolism ; Nucleosomes/chemistry ; Nucleosomes/metabolism
Czasopismo naukowe
Tytuł:
Backup transcription factor binding sites protect human genes from mutations in the promoter.
Autorzy:
Brown JC; Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America.
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Źródło:
PloS one [PLoS One] 2023 Aug 31; Vol. 18 (8), pp. e0281569. Date of Electronic Publication: 2023 Aug 31 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Transcription Factors*/metabolism
Promoter Regions, Genetic*/genetics
Gene Expression Regulation*
Brain*/metabolism
Humans ; Binding Sites ; Mutation ; Databases, Genetic ; Liver/metabolism
Czasopismo naukowe
Tytuł:
OnTarget: in silico design of MiniPromoters for targeted delivery of expression.
Autorzy:
Fornes O; Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.
Av-Shalom TV; Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.; Department of Cell and Systems Biology, University of Toronto, Toronto, Canada.
Korecki AJ; Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.
Farkas RA; Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.
Arenillas DJ; Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.
Mathelier A; Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, Oslo, Norway.; Department of Medical Genetics, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway.
Simpson EM; Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.
Wasserman WW; Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2023 Jul 05; Vol. 51 (W1), pp. W379-W386.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Promoter Regions, Genetic*/genetics
Computer Simulation*
Software*
Computational Biology*/instrumentation
Computational Biology*/methods
Enhancer Elements, Genetic/genetics ; Genome ; Genomics ; Internet
Czasopismo naukowe
Tytuł:
Complementary Alu sequences mediate enhancer-promoter selectivity.
Autorzy:
Liang L; Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Cao C; Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Ji L; Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Cai Z; Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Wang D; Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Ye R; Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Chen J; Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Yu X; Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Zhou J; Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Bai Z; School of Life Sciences, Henan Normal University, Xinxiang, China.
Wang R; School of Life Sciences, Henan Normal University, Xinxiang, China.
Yang X; School of Life Sciences, Henan Normal University, Xinxiang, China.
Zhu P; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Xue Y; Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. .; University of Chinese Academy of Sciences, Beijing, China. .
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Źródło:
Nature [Nature] 2023 Jul; Vol. 619 (7971), pp. 868-875. Date of Electronic Publication: 2023 Jul 12.
Typ publikacji:
Journal Article
MeSH Terms:
Alu Elements*/genetics
Enhancer Elements, Genetic*/genetics
Promoter Regions, Genetic*/genetics
RNA*/chemistry
RNA*/genetics
RNA*/metabolism
Cell Line ; Focal Adhesion Kinase 1/genetics ; Gene Expression Regulation ; Nucleic Acid Conformation ; Nucleic Acid Heteroduplexes ; Sequence Deletion
Czasopismo naukowe
Tytuł:
Stochastic motion and transcriptional dynamics of pairs of distal DNA loci on a compacted chromosome.
Autorzy:
Brückner DB; Institute of Science and Technology, Am Campus 1, Klosterneuburg, Austria.
Chen H; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Barinov L; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Zoller B; Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ, USA.; Department of Developmental and Stem Cell Biology, CNRS UMR3738 Paris Cité, Institut Pasteur, Paris, France.
Gregor T; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.; Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ, USA.; Department of Developmental and Stem Cell Biology, CNRS UMR3738 Paris Cité, Institut Pasteur, Paris, France.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Jun 30; Vol. 380 (6652), pp. 1357-1362. Date of Electronic Publication: 2023 Jun 29.
Typ publikacji:
Journal Article
MeSH Terms:
Chromosomes*/chemistry
Chromosomes*/genetics
DNA*/chemistry
DNA*/genetics
Transcription, Genetic*
Molecular Imaging*/methods
Enhancer Elements, Genetic*
Promoter Regions, Genetic*
Cell Nucleus/metabolism ; Eukaryota ; Polymers/chemistry ; Animals ; Drosophila
Czasopismo naukowe
Tytuł:
Defining the fine structure of promoter activity on a genome-wide scale with CISSECTOR.
Autorzy:
FitzPatrick VD; Department of Biological Sciences, Columbia University, New York, NY, USA.; Department of Systems Biology, Columbia University Medical Center, New York, NY, USA.
Leemans C; Division of Gene Regulation, Oncode Institute, Netherlands Cancer Institute, Amsterdam, The Netherlands.
van Arensbergen J; Division of Gene Regulation, Oncode Institute, Netherlands Cancer Institute, Amsterdam, The Netherlands.
van Steensel B; Division of Gene Regulation, Oncode Institute, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Cell Biology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Bussemaker HJ; Department of Biological Sciences, Columbia University, New York, NY, USA.; Department of Systems Biology, Columbia University Medical Center, New York, NY, USA.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2023 Jun 23; Vol. 51 (11), pp. 5499-5511.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Promoter Regions, Genetic*
Software*
Humans ; Binding Sites ; Genome, Human/genetics ; Protein Binding ; Regulatory Sequences, Nucleic Acid
Czasopismo naukowe
Tytuł:
The two sRNAs OmrA and OmrB indirectly repress transcription from the LEE1 promoter of enteropathogenic Escherichia coli.
Autorzy:
Muche S; Department of Biology, Saint Joseph's University, 5600 City Avenue, SC124, Philadelphia, PA, 19131, USA.
El-Fenej J; Department of Biology, Saint Joseph's University, 5600 City Avenue, SC124, Philadelphia, PA, 19131, USA.; Center for Immunity and Inflammation and Department of Pathology, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Mihaita A; Department of Biology, Saint Joseph's University, 5600 City Avenue, SC124, Philadelphia, PA, 19131, USA.
Mrozek Z; Department of Biology, Saint Joseph's University, 5600 City Avenue, SC124, Philadelphia, PA, 19131, USA.
Cleary S; Department of Biology, Saint Joseph's University, 5600 City Avenue, SC124, Philadelphia, PA, 19131, USA.; Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA, 19131, USA.
Critelli B; Department of Biology, Saint Joseph's University, 5600 City Avenue, SC124, Philadelphia, PA, 19131, USA.
Marino M; Department of Biology, Saint Joseph's University, 5600 City Avenue, SC124, Philadelphia, PA, 19131, USA.
Yu W; Department of Biology, Saint Joseph's University, 5600 City Avenue, SC124, Philadelphia, PA, 19131, USA.
Amos B; Department of Biology, Saint Joseph's University, 5600 City Avenue, SC124, Philadelphia, PA, 19131, USA.
Hunter T; Department of Biology, Saint Joseph's University, 5600 City Avenue, SC124, Philadelphia, PA, 19131, USA.
Riga M; Department of Biology, Saint Joseph's University, 5600 City Avenue, SC124, Philadelphia, PA, 19131, USA.
Buerkert T; Department of Biology, Saint Joseph's University, 5600 City Avenue, SC124, Philadelphia, PA, 19131, USA.
Bhatt S; Department of Biology, Saint Joseph's University, 5600 City Avenue, SC124, Philadelphia, PA, 19131, USA. .
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Źródło:
Folia microbiologica [Folia Microbiol (Praha)] 2023 Jun; Vol. 68 (3), pp. 415-430. Date of Electronic Publication: 2022 Dec 22.
Typ publikacji:
Journal Article
MeSH Terms:
Enteropathogenic Escherichia coli*
Promoter Regions, Genetic*
Transcription Factors
Czasopismo naukowe
Tytuł:
Requirements for mammalian promoters to decode transcription factor dynamics.
Autorzy:
Antwi EB; Heidelberg Biosciences International Graduate School (HBIGS), University of Heidelberg, Heidelberg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Faculty of Biology, Institute of Biology II, University of Freiburg, Freiburg, Germany.
Marrakchi Y; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Department of Computer Science, University of Freiburg, Freiburg, Germany.
Çiçek Ö; Department of Computer Science, University of Freiburg, Freiburg, Germany.
Brox T; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Department of Computer Science, University of Freiburg, Freiburg, Germany.; BrainLinks-BrainTools, University of Freiburg, Freiburg, Germany.
Di Ventura B; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Faculty of Biology, Institute of Biology II, University of Freiburg, Freiburg, Germany.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2023 May 22; Vol. 51 (9), pp. 4674-4690.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation*
Promoter Regions, Genetic*
Transcription Factors*/genetics
Transcription Factors*/metabolism
Animals ; Mammals ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Protein Binding
Czasopismo naukowe
Tytuł:
Structural polymorphism driven by a register shift in a CGAG-rich region found in the promoter of the neurodevelopmental regulator AUTS2 gene.
Autorzy:
Novotný A; Slovenian NMR Centre, National Institute of Chemistry, Ljubljana SI-1000, Slovenia.; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana SI-1000, Slovenia.
Plavec J; Slovenian NMR Centre, National Institute of Chemistry, Ljubljana SI-1000, Slovenia.; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana SI-1000, Slovenia.; EN-FIST Centre of Excellence, Ljubljana SI-1000, Slovenia.
Kocman V; Slovenian NMR Centre, National Institute of Chemistry, Ljubljana SI-1000, Slovenia.; EN-FIST Centre of Excellence, Ljubljana SI-1000, Slovenia.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2023 Apr 11; Vol. 51 (6), pp. 2602-2613.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cytoskeletal Proteins*/genetics
Promoter Regions, Genetic*
Transcription Factors*/genetics
Humans ; Autism Spectrum Disorder/genetics ; Base Pairing ; Cell Movement ; Protein Isoforms/genetics
Czasopismo naukowe
Tytuł:
Recent progress and challenges in single-cell imaging of enhancer-promoter interaction.
Autorzy:
Chen LF; Department of Chemical and Systems Biology, Stanford University, USA.
Lee J; Department of Developmental Biology, Stanford University, USA.
Boettiger A; Department of Developmental Biology, Stanford University, USA. Electronic address: .
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Źródło:
Current opinion in genetics & development [Curr Opin Genet Dev] 2023 Apr; Vol. 79, pp. 102023. Date of Electronic Publication: 2023 Feb 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Single-Cell Analysis*/methods
Enhancer Elements, Genetic*/genetics
Promoter Regions, Genetic*/genetics
Chromatin/genetics ; Chromatin/metabolism ; Gene Expression Regulation ; Transcription, Genetic ; Time Factors ; Humans ; Animals
Czasopismo naukowe

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