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Wyświetlanie 1-20 z 37
Tytuł:
A 3-week nonalcoholic steatohepatitis mouse model shows elafibranor benefits on hepatic inflammation and cell death.
Autorzy:
Briand F; Physiogenex, Escalquens, France.
Heymes C; Inserm U1048 CHU Rangueil, Toulouse Cedex 4, France.
Bonada L; Physiogenex, Escalquens, France.
Angles T; Inserm U1048 CHU Rangueil, Toulouse Cedex 4, France.
Charpentier J; Inserm U1048 CHU Rangueil, Toulouse Cedex 4, France.
Branchereau M; Inserm U1048 CHU Rangueil, Toulouse Cedex 4, France.
Brousseau E; Physiogenex, Escalquens, France.
Quinsat M; Physiogenex, Escalquens, France.
Fazilleau N; Inserm CPTP-U1043 CHU Purpan, Toulouse Cedex 3, France.
Burcelin R; Inserm U1048 CHU Rangueil, Toulouse Cedex 4, France.
Sulpice T; Physiogenex, Escalquens, France.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2020 May; Vol. 13 (3), pp. 529-538. Date of Electronic Publication: 2020 Jan 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chalcones/*pharmacology
Liver/*drug effects
Non-alcoholic Fatty Liver Disease/*drug therapy
Propionates/*pharmacology
Animals ; Apoptosis/drug effects ; Apoptosis/immunology ; Chalcones/therapeutic use ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Humans ; Liver/immunology ; Liver/pathology ; Male ; Mice ; Necroptosis/drug effects ; Necroptosis/immunology ; Non-alcoholic Fatty Liver Disease/immunology ; Non-alcoholic Fatty Liver Disease/pathology ; Propionates/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hepatic steatosis induced in C57BL/6 mice by a non-ß oxidizable fatty acid analogue is associated with reduced plasma kynurenine metabolites and a modified hepatic NAD /NADH ratio.
Autorzy:
Berge RK; Department of Clinical Science, University of Bergen, Bergen, Norway. .; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway. .
Cacabelos D; Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.
Señarís R; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.
Nordrehaug JE; Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Heart Disease, Stavanger University Hospital, Stavanger, Norway.
Nygård O; Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.; KG Jebsen Centre for Diabetes Research, University of Bergen, Bergen, Norway.
Skorve J; Department of Clinical Science, University of Bergen, Bergen, Norway.
Bjørndal B; Department of Clinical Science, University of Bergen, Bergen, Norway.
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Źródło:
Lipids in health and disease [Lipids Health Dis] 2020 May 14; Vol. 19 (1), pp. 94. Date of Electronic Publication: 2020 May 14.
Typ publikacji:
Journal Article
MeSH Terms:
Kynurenine/*metabolism
Liver/*metabolism
NAD/*metabolism
Non-alcoholic Fatty Liver Disease/*metabolism
Triglycerides/*analysis
Animals ; Arachidonic Acid/analysis ; Disease Models, Animal ; Inflammation ; Kynurenine/blood ; Male ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/chemically induced ; Oxidative Stress ; Propionates/toxicity ; Sulfides/toxicity ; Tryptophan/blood ; Tryptophan/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Validity of biopsy-based drug effects in a diet-induced obese mouse model of biopsy-confirmed NASH.
Autorzy:
Baandrup Kristiansen MN; Gubra Aps, Hoersholm, Denmark.; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Veidal SS; Gubra Aps, Hoersholm, Denmark.
Christoffersen C; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Bispebjerg Hospital and Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Feigh M; Gubra Aps, Hoersholm, Denmark.
Vrang N; Gubra Aps, Hoersholm, Denmark.
Roth JD; Intercept Pharmaceuticals, San Diego, California, USA.
Erickson M; Intercept Pharmaceuticals, San Diego, California, USA.
Adorini L; Intercept Pharmaceuticals, San Diego, California, USA.
Jelsing J; Gubra Aps, Hoersholm, Denmark. .
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Źródło:
BMC gastroenterology [BMC Gastroenterol] 2019 Dec 28; Vol. 19 (1), pp. 228. Date of Electronic Publication: 2019 Dec 28.
Typ publikacji:
Journal Article
MeSH Terms:
Liver/*drug effects
Liver/*pathology
Non-alcoholic Fatty Liver Disease/*drug therapy
Non-alcoholic Fatty Liver Disease/*pathology
Obesity/*complications
Animals ; Bile Acids and Salts/therapeutic use ; Biopsy ; Body Weight/drug effects ; Chalcones/therapeutic use ; Collagen Type I/analysis ; Diet, High-Fat ; Galectin 3/analysis ; Islet Amyloid Polypeptide/administration & dosage ; Leptin/deficiency ; Lipids/analysis ; Liraglutide/therapeutic use ; Liver/chemistry ; Liver Cirrhosis/pathology ; Male ; Mice ; Mice, Obese ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Organ Size/drug effects ; PPAR alpha/agonists ; PPAR delta/agonists ; Propionates/therapeutic use ; Reproducibility of Results
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effects of Liver Resection on Hepatic Short-Chain Fatty Acid Metabolism in Humans.
Autorzy:
Neis EP; TI Food and Nutrition, 6709 PA Wageningen, The Netherlands.; Department of Surgery, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands.
Bloemen JG; TI Food and Nutrition, 6709 PA Wageningen, The Netherlands.; Department of Surgery, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands.
Rensen SS; Department of Surgery, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands.
van der Vorst JR; Department of Surgery, Leiden University Medical Centre, 2333 ZA Leiden, The Netherlands.
van den Broek MA; Department of Surgery, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands.; Department of Surgery, Leiden University Medical Centre, 2333 ZA Leiden, The Netherlands.
Venema K; TI Food and Nutrition, 6709 PA Wageningen, The Netherlands.; Beneficial Microbes Consultancy, Wageningen University, 6708 PB Wageningen, The Netherlands.
Buurman WA; Department of Surgery, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands.
Dejong CH; TI Food and Nutrition, 6709 PA Wageningen, The Netherlands.
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Źródło:
PloS one [PLoS One] 2016 Nov 11; Vol. 11 (11), pp. e0166161. Date of Electronic Publication: 2016 Nov 11 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Fatty Acids, Volatile/*metabolism
Hepatectomy/*methods
Liver/*metabolism
Liver/*surgery
Acetates/metabolism ; Adult ; Aged ; Butyric Acid/metabolism ; Fatty Acids, Volatile/blood ; Female ; Hepatic Veins/metabolism ; Humans ; Liver/blood supply ; Male ; Middle Aged ; Portal Vein/metabolism ; Postoperative Period ; Preoperative Period ; Propionates ; Radial Artery/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
GPR40 agonist ameliorates liver X receptor-induced lipid accumulation in liver by activating AMPK pathway.
Autorzy:
Li M; Peking University Fifth School of Clinical Medicine (Beijing Hospital), Beijing, China.; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics &Beijing Hospital, Ministry of Health, Beijing, China.
Meng X; Peking University Fifth School of Clinical Medicine (Beijing Hospital), Beijing, China.; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics &Beijing Hospital, Ministry of Health, Beijing, China.
Xu J; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics &Beijing Hospital, Ministry of Health, Beijing, China.
Huang X; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics &Beijing Hospital, Ministry of Health, Beijing, China.
Li H; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics &Beijing Hospital, Ministry of Health, Beijing, China.
Li G; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics &Beijing Hospital, Ministry of Health, Beijing, China.
Wang S; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics &Beijing Hospital, Ministry of Health, Beijing, China.
Man Y; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics &Beijing Hospital, Ministry of Health, Beijing, China.
Tang W; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics &Beijing Hospital, Ministry of Health, Beijing, China.
Li J; Peking University Fifth School of Clinical Medicine (Beijing Hospital), Beijing, China.; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics &Beijing Hospital, Ministry of Health, Beijing, China.
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Źródło:
Scientific reports [Sci Rep] 2016 Apr 28; Vol. 6, pp. 25237. Date of Electronic Publication: 2016 Apr 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lipid Metabolism*
AMP-Activated Protein Kinases/*metabolism
Liver/*metabolism
Liver X Receptors/*metabolism
Receptors, G-Protein-Coupled/*agonists
Animals ; Hep G2 Cells ; Humans ; Methylamines/administration & dosage ; Mice, Inbred C57BL ; Propionates/administration & dosage
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Tetradecylthiopropionic acid induces hepatic mitochondrial dysfunction and steatosis, accompanied by increased plasma homocysteine in mice.
Autorzy:
Berge RK; Department of Clinical Science, University of Bergen, 5020, Bergen, Norway. .; Department of Heart Disease, Haukeland University Hospital, 5021, Bergen, Norway. .
Bjørndal B; Department of Clinical Science, University of Bergen, 5020, Bergen, Norway. .
Strand E; Department of Clinical Science, University of Bergen, 5020, Bergen, Norway. .
Bohov P; Department of Clinical Science, University of Bergen, 5020, Bergen, Norway. .
Lindquist C; Department of Clinical Science, University of Bergen, 5020, Bergen, Norway. .
Nordrehaug JE; Department of Clinical Science, University of Bergen, 5020, Bergen, Norway. .; Department of Heart Disease, Stavanger University Hospital, 4142, Stavanger, Norway. .
Svardal A; Department of Clinical Science, University of Bergen, 5020, Bergen, Norway. .
Skorve J; Department of Clinical Science, University of Bergen, 5020, Bergen, Norway. .
Nygård O; Department of Clinical Science, University of Bergen, 5020, Bergen, Norway. .; Department of Heart Disease, Haukeland University Hospital, 5021, Bergen, Norway. .; KG Jebsen Centre for Diabetes Research, University of Bergen, 5020, Bergen, Norway. .
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Źródło:
Lipids in health and disease [Lipids Health Dis] 2016 Feb 05; Vol. 15, pp. 24. Date of Electronic Publication: 2016 Feb 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Fatty Liver/*chemically induced
Homocysteine/*blood
Liver/*drug effects
Liver/*metabolism
Propionates/*pharmacology
Sulfides/*pharmacology
Animals ; Fatty Liver/metabolism ; Male ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; Non-alcoholic Fatty Liver Disease/chemically induced ; Non-alcoholic Fatty Liver Disease/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Gut microbiota-derived propionate reduces cancer cell proliferation in the liver.
Autorzy:
Bindels LB; Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Porporato P
Dewulf EM
Verrax J
Neyrinck AM
Martin JC
Scott KP
Buc Calderon P
Feron O
Muccioli GG
Sonveaux P
Cani PD
Delzenne NM
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2012 Oct 09; Vol. 107 (8), pp. 1337-44. Date of Electronic Publication: 2012 Sep 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Fructans/*administration & dosage
Intestines/*microbiology
Leukemia/*metabolism
Liver/*pathology
Metagenome/*immunology
Propionates/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Animals ; Cell Proliferation ; Diet ; Disease Models, Animal ; Fatty Acids, Volatile/metabolism ; Female ; Fructans/metabolism ; Fructans/pharmacology ; Metagenome/drug effects ; Mice ; Mice, Inbred BALB C ; Prebiotics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Stereoselective hepatic disposition of a diastereomeric pair of alphavbeta3 antagonists in rat.
Autorzy:
Prueksaritanont T; Department of Drug Metabolism, Merck Reseach Laboratories, West Point, PA 19486, USA. thomayant_ />Xu X
Deluna P
Yamazaki M
Lin JH
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2003 Nov; Vol. 33 (11), pp. 1125-37.
Typ publikacji:
Journal Article
MeSH Terms:
Integrin alphaVbeta3/*antagonists & inhibitors
Liver/*metabolism
Propionates/*pharmacology
Quinolines/*pharmacology
Animals ; Area Under Curve ; Bile Canaliculi/metabolism ; Chromatography, High Pressure Liquid ; Hyperbilirubinemia/metabolism ; In Vitro Techniques ; Male ; Naphthyridines ; Perfusion ; Pyrrolidines ; Rats ; Rats, Sprague-Dawley ; Stereoisomerism ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
On the effects of thia fatty acid analogues on hydrolases involved in the degradation of metabolisable and non-metabolisable acyl-CoA esters.
Autorzy:
Garras A; University of Bergen, Department of Clinical Biology, Haukeland Hospital, Norway.
Elholm M
Sleboda J
Frøyland L
Osmundsen H
Berge RK
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 1997 Aug; Vol. 27 (8), pp. 781-99.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acyl Coenzyme A/*metabolism
Esters/*metabolism
Fatty Acids/*pharmacology
Liver/*enzymology
Palmitoyl-CoA Hydrolase/*metabolism
Sulfides/*pharmacology
Animals ; Clofibric Acid/analogs & derivatives ; Clofibric Acid/metabolism ; Cytosol/enzymology ; Liver/ultrastructure ; Male ; Microbodies/enzymology ; Microsomes, Liver/enzymology ; Mitochondria, Liver/enzymology ; Palmitoyl Coenzyme A/metabolism ; Propionates/metabolism ; Rats ; Rats, Wistar ; Substrate Specificity ; Sulfides/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Hepatic fatty acid metabolism as a determinant of plasma and liver triacylglycerol levels. Studies on tetradecylthioacetic and tetradecylthiopropionic acids.
Autorzy:
Asiedu DK; Institute of Clinical Biology, University of Bergen, Haukeland University Hospital, Norway.
al-Shurbaji A
Rustan AC
Björkhem I
Berglund L
Berge RK
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Źródło:
European journal of biochemistry [Eur J Biochem] 1995 Feb 01; Vol. 227 (3), pp. 715-22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Fatty Acids/*metabolism
Liver/*drug effects
Liver/*metabolism
Propionates/*pharmacology
Sulfides/*pharmacology
Triglycerides/*blood
Triglycerides/*metabolism
Animals ; Cholesterol/biosynthesis ; Cholesterol/metabolism ; Cholesterol Esters/biosynthesis ; Lipids/blood ; Lipoproteins/blood ; Male ; Oxidation-Reduction ; Rats ; Rats, Wistar
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Carbon-dioxide concentration and the distribution of monocarboxylate and H+ ions between intracellular and extracellular spaces of hemoglobin-free perfused rat liver.
Autorzy:
Sies H
Noack G
Halder KH
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Źródło:
European journal of biochemistry [Eur J Biochem] 1973 Oct 05; Vol. 38 (2), pp. 247-58.
Typ publikacji:
Journal Article
MeSH Terms:
Carbon Dioxide/*metabolism
Carboxylic Acids/*metabolism
Extracellular Space/*metabolism
Hydrogen/*metabolism
Liver/*metabolism
Acetates/metabolism ; Animals ; Benzoates/metabolism ; Butyrates/metabolism ; Formates/metabolism ; Hemoglobins/physiology ; Hydrogen-Ion Concentration ; In Vitro Techniques ; Lactates/metabolism ; Male ; Oxyphenbutazone/metabolism ; Perfusion ; Phthalic Acids/metabolism ; Propionates/metabolism ; Pyruvates/metabolism ; Rats ; Succinates/metabolism ; Sulfonic Acids/metabolism ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Enzymatic catalysis in the affinity labelling of liver alcohol dehydrogenase with haloacids.
Autorzy:
Dahl KH
McKinley-Mckee JS
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Źródło:
European journal of biochemistry [Eur J Biochem] 1981 Sep 01; Vol. 118 (3), pp. 507-13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetates*/*pharmacology
Alcohol Oxidoreductases/*metabolism
Iodoacetates/*pharmacology
Liver/*enzymology
Propionates/*pharmacology
Affinity Labels ; Alcohol Oxidoreductases/antagonists & inhibitors ; Alkylation ; Animals ; Catalysis ; Horses ; Iodoacetic Acid ; Kinetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Microsomal and cytosolic epoxide hydrolases, the peroxisomal fatty acid beta-oxidation system and catalase. Activities, distribution and induction in rat liver parenchymal and non-parenchymal cells.
Autorzy:
Steinberg P; Institut für Toxikologie, Universität Mainz, Federal Republic of Germany.
Schladt L
Dienes HP
Timms C
Oesch F
Pokaż więcej
Źródło:
European journal of biochemistry [Eur J Biochem] 1988 Sep 01; Vol. 176 (1), pp. 39-45.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Catalase/*metabolism
Epoxide Hydrolases/*metabolism
Fatty Acids/*metabolism
Fenofibrate/*pharmacology
Hypolipidemic Agents/*pharmacology
Liver/*enzymology
Propionates/*pharmacology
Animals ; Cytosol/enzymology ; Endothelium/enzymology ; Kupffer Cells/enzymology ; Liver/drug effects ; Male ; Microbodies/enzymology ; Microsomes, Liver/enzymology ; Oxidation-Reduction ; Rats ; Rats, Inbred Strains
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A transition-state analysis of the enzyme catalysis in the affinity labelling of horse-liver alcohol dehydrogenase by bromoacids.
Autorzy:
Brandsnes O
Dahl KH
McKinley-McKee JS
Pokaż więcej
Źródło:
European journal of biochemistry [Eur J Biochem] 1982 Aug; Vol. 126 (2), pp. 247-52.
Typ publikacji:
Journal Article
MeSH Terms:
Acetates/*pharmacology
Alcohol Oxidoreductases/*antagonists & inhibitors
Liver/*enzymology
Affinity Labels ; Alcohol Dehydrogenase ; Alkylation ; Animals ; Binding Sites ; Catalysis ; Horses ; Imidazoles/pharmacology ; Propionates/pharmacology ; Thermodynamics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effect of the exposure to Mn-doped ZnS nanoparticles on biomarkers in the freshwater western mosquitofish Gambusia affinis.
Autorzy:
Touaylia, Samir
Labiadh, Houcine
Pokaż więcej
Temat:
ANALYSIS of hydrogen peroxide
ZINC analysis
SULFIDES analysis
ACETYLCHOLINESTERASE
ANIMAL experimentation
BIOMARKERS
BRAIN
CATALASE
CHEMILUMINESCENCE assay
ELECTRON microscopy
FISHES
LIVER
MANGANESE
NANOPARTICLES
PROPIONATES
SPECTRUM analysis
STAINS & staining (Microscopy)
TOXICITY testing
ULTRAVIOLET radiation
X-rays
MALONDIALDEHYDE
ENVIRONMENTAL exposure
Źródło:
International Journal of Environmental Health Research; Feb2019, Vol. 29 Issue 1, p60-70, 11p, 4 Graphs
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 37

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