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Wyszukujesz frazę ""Proprotein Convertases"" wg kryterium: Temat


Tytuł:
Hepatic glycogenesis antagonizes lipogenesis by blocking S1P via UDPG.
Autorzy:
Chen J; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Zhou Y; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Liu Z; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Lu Y; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Jiang Y; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Cao K; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Zhou N; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Wang D; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Zhang C; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.; Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Zhou N; Department of Pathology, Sichuan Mianyang 404 Hospital, Sichuan 621000, China.
Shi K; Translational Medicine Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Zhang L; Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
Zhou L; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Wang Z; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Zhang H; Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Tang K; Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Ma J; Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Lv J; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Huang B; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.; Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
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Źródło:
Science (New York, N.Y.) [Science] 2024 Feb 16; Vol. 383 (6684), pp. eadi3332. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
Lipogenesis*
Liver*/metabolism
Liver Glycogen*/metabolism
Non-alcoholic Fatty Liver Disease*/drug therapy
Non-alcoholic Fatty Liver Disease*/metabolism
Proprotein Convertases*/metabolism
Serine Endopeptidases*
Uridine Diphosphate Glucose*/administration & dosage
Uridine Diphosphate Glucose*/metabolism
Animals ; Humans ; Mice ; Carbon/metabolism ; Glucose/metabolism ; Hepatocytes/metabolism ; Sterol Regulatory Element Binding Protein 1/genetics ; Sterol Regulatory Element Binding Protein 1/metabolism ; Male ; Mice, Inbred C57BL ; HEK293 Cells
Czasopismo naukowe
Tytuł:
The Inhibition of the Membrane-Bound Transcription Factor Site-1 Protease (MBTP1) Alleviates the p.Phe508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Defects in Cystic Fibrosis Cells.
Autorzy:
Santinelli R; Univ Brest, Inserm, EFS, UMR 1078, 22 Avenue Camille Desmoulins, F-29200 Brest, France.
Benz N; Univ Brest, Inserm, EFS, UMR 1078, 22 Avenue Camille Desmoulins, F-29200 Brest, France.
Guellec J; Univ Brest, Inserm, EFS, UMR 1078, 22 Avenue Camille Desmoulins, F-29200 Brest, France.
Quinquis F; Univ Brest, Inserm, EFS, UMR 1078, 22 Avenue Camille Desmoulins, F-29200 Brest, France.
Kocas E; Univ Brest, Inserm, EFS, UMR 1078, 22 Avenue Camille Desmoulins, F-29200 Brest, France.
Thomas J; Univ Brest, Inserm, EFS, UMR 1078, 22 Avenue Camille Desmoulins, F-29200 Brest, France.
Montier T; Univ Brest, Inserm, EFS, UMR 1078, 22 Avenue Camille Desmoulins, F-29200 Brest, France.
Ka C; Univ Brest, Inserm, EFS, UMR 1078, 22 Avenue Camille Desmoulins, F-29200 Brest, France.
Luczka-Majérus E; Inserm UMR-S 1250, University of Reims Champagne-Ardenne (URCA), SFR Cap-Santé, F-51100 Reims, France.
Sage E; Université Paris-Saclay, INRAE, UVSQ, VIM, F-78350 Jouy-en-Josas, France.
Férec C; Univ Brest, Inserm, EFS, UMR 1078, 22 Avenue Camille Desmoulins, F-29200 Brest, France.
Coraux C; Inserm UMR-S 1250, University of Reims Champagne-Ardenne (URCA), SFR Cap-Santé, F-51100 Reims, France.
Trouvé P; Univ Brest, Inserm, EFS, UMR 1078, 22 Avenue Camille Desmoulins, F-29200 Brest, France.
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Źródło:
Cells [Cells] 2024 Jan 18; Vol. 13 (2). Date of Electronic Publication: 2024 Jan 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cystic Fibrosis Transmembrane Conductance Regulator*/genetics
Cystic Fibrosis*/genetics
Proprotein Convertases*
Humans ; Transcription Factors ; Serine Endopeptidases
Czasopismo naukowe
Tytuł:
Proprotein convertase cleavage of Ictalurid herpesvirus 1 spike-like protein ORF46 is modulated by N-glycosylation.
Autorzy:
Yu F; Jiangsu Province Engineering Research Center for Marine Bio-resources Sustainable Utilization, Hohai University, Nanjing 210024, China.
Xu J; Jiangsu Province Engineering Research Center for Marine Bio-resources Sustainable Utilization, Hohai University, Nanjing 210024, China.
Chen H; Jiangsu Province Engineering Research Center for Marine Bio-resources Sustainable Utilization, Hohai University, Nanjing 210024, China.
Song S; Jiangsu Province Engineering Research Center for Marine Bio-resources Sustainable Utilization, Hohai University, Nanjing 210024, China.
Nie C; Jiangsu Province Engineering Research Center for Marine Bio-resources Sustainable Utilization, Hohai University, Nanjing 210024, China.
Hao K; Jiangsu Province Engineering Research Center for Marine Bio-resources Sustainable Utilization, Hohai University, Nanjing 210024, China.
Zhao Z; Jiangsu Province Engineering Research Center for Marine Bio-resources Sustainable Utilization, Hohai University, Nanjing 210024, China. Electronic address: .
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Źródło:
Virology [Virology] 2024 Apr; Vol. 592, pp. 110008. Date of Electronic Publication: 2024 Feb 06.
Typ publikacji:
Journal Article
MeSH Terms:
Proprotein Convertases*/genetics
Proprotein Convertases*/metabolism
Ictalurivirus*
Animals ; Glycosylation ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Antiviral Agents
Czasopismo naukowe
Tytuł:
Diversity in Proprotein Convertase Reactivity among Human Papillomavirus Types.
Autorzy:
Izaguirre G; Department of Periodontics, College of Dentistry, University of Illinois Chicago, Chicago, IL 60612, USA.
Phan LMU; Department of Periodontics, College of Dentistry, University of Illinois Chicago, Chicago, IL 60612, USA.
Asif S; Department of Periodontics, College of Dentistry, University of Illinois Chicago, Chicago, IL 60612, USA.
Alam S; Departments of Microbiology and Immunology, College of Medicine, Penn State University, Hershey, PA 17033, USA.
Meyers C; Departments of Microbiology and Immunology, College of Medicine, Penn State University, Hershey, PA 17033, USA.
Rong L; Departments of Microbiology and Immunology, College of Medicine, University of Illinois Chicago, Chicago, IL 60612, USA.
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Źródło:
Viruses [Viruses] 2023 Dec 26; Vol. 16 (1). Date of Electronic Publication: 2023 Dec 26.
Typ publikacji:
Journal Article
MeSH Terms:
Proprotein Convertases*
Papillomavirus Infections*
Humans ; Furin ; Human Papillomavirus Viruses ; Human papillomavirus 16/genetics
Czasopismo naukowe
Tytuł:
Synthetic Site-Specific Antibody-Ligand Conjugates Promote Asialoglycoprotein Receptor-Mediated Degradation of Extracellular Human PCSK9.
Autorzy:
Donahue TC; Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States.
Ou C; Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States.
Yang Q; Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States.
Flinko R; Division of Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.
Zhang X; Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States.
Zong G; Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States.
Lewis GK; Division of Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.
Wang LX; Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States.
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Źródło:
ACS chemical biology [ACS Chem Biol] 2023 Jul 21; Vol. 18 (7), pp. 1611-1623. Date of Electronic Publication: 2023 Jun 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Serine Endopeptidases*/metabolism
Proprotein Convertases*/metabolism
Humans ; Asialoglycoprotein Receptor ; Ligands ; Asialoglycoproteins ; Cetuximab ; Cholesterol, LDL/metabolism
Czasopismo naukowe
Tytuł:
Proprotein convertase subtilisin/kexin 9 inhibitor downregulates microRNA-130a-3p expression in hepatocytes to alleviates atherosclerosis progression.
Autorzy:
Xu J; The Department of Cardiology, Tianjin Chest Hospital, No. 261, Taierzhuang South Road, Jinnan District, Tianjin, 300222, China.; The Department of Cardiology, Chest Hospital, Tianjin University, Tianjin, China.; Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin Municipal Science and Technology Bureau, Tianjin, China.; TianJin Institute of Cardiovascular Diseases, Tianjin, China.
Zuo J; Internal Medicine, Tianjin Jinnan Hospital, Tianjin, China.
Han C; The Department of Cardiology, Tianjin Chest Hospital, No. 261, Taierzhuang South Road, Jinnan District, Tianjin, 300222, China.; The Department of Cardiology, Chest Hospital, Tianjin University, Tianjin, China.; Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin Municipal Science and Technology Bureau, Tianjin, China.; TianJin Institute of Cardiovascular Diseases, Tianjin, China.
Li T; The Department of Cardiology, Tianjin Chest Hospital, No. 261, Taierzhuang South Road, Jinnan District, Tianjin, 300222, China.; The Department of Cardiology, Chest Hospital, Tianjin University, Tianjin, China.; Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin Municipal Science and Technology Bureau, Tianjin, China.; TianJin Institute of Cardiovascular Diseases, Tianjin, China.
Jin D; The Department of Cardiology, Tianjin Chest Hospital, No. 261, Taierzhuang South Road, Jinnan District, Tianjin, 300222, China.; The Department of Cardiology, Chest Hospital, Tianjin University, Tianjin, China.; Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin Municipal Science and Technology Bureau, Tianjin, China.; TianJin Institute of Cardiovascular Diseases, Tianjin, China.
Zhao F; The Department of Cardiology, Tianjin Chest Hospital, No. 261, Taierzhuang South Road, Jinnan District, Tianjin, 300222, China.; The Department of Cardiology, Chest Hospital, Tianjin University, Tianjin, China.; Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin Municipal Science and Technology Bureau, Tianjin, China.; TianJin Institute of Cardiovascular Diseases, Tianjin, China.
Cong H; The Department of Cardiology, Tianjin Chest Hospital, No. 261, Taierzhuang South Road, Jinnan District, Tianjin, 300222, China. .; The Department of Cardiology, Chest Hospital, Tianjin University, Tianjin, China. .; Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin Municipal Science and Technology Bureau, Tianjin, China. .; TianJin Institute of Cardiovascular Diseases, Tianjin, China. .
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Źródło:
Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Mar; Vol. 397 (3), pp. 1727-1736. Date of Electronic Publication: 2023 Sep 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Coronary Artery Disease*
Atherosclerosis*/drug therapy
Atherosclerosis*/genetics
Atherosclerosis*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
Mice ; Animals ; Humans ; Proprotein Convertase 9/genetics ; Proprotein Convertase 9/metabolism ; Proprotein Convertase 9/pharmacology ; Subtilisin/metabolism ; Subtilisin/pharmacology ; Receptors, LDL/genetics ; Receptors, LDL/metabolism ; Mice, Knockout, ApoE ; Proprotein Convertases/genetics ; Proprotein Convertases/metabolism ; Proprotein Convertases/pharmacology ; Hepatocytes ; Hep G2 Cells
Czasopismo naukowe
Tytuł:
The association of serum proprotein convertase furin/PCSK3 concentrations with stable coronary artery disease and coroner artery lesion severity.
Autorzy:
Yucesan, Fulya Balaban
Orem, Asim
Orem, Cihan
Ilter, Abdulselam
Yaman, Serap Ozer
Yaman, Huseyin
Akcan, Buket
Sen, Tugba Mazlum
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Źródło:
International Journal of Medical Biochemistry. 2024, Vol. 7 Issue 1, p18-25. 8p.
Czasopismo naukowe
Tytuł:
Repurposing an endogenous degradation domain for antibody-mediated disposal of cell-surface proteins.
Autorzy:
Schmitt J; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Hills Road, CB2 0SP, Cambridge, UK.; Faculty of Medicine, Charité Berlin, 10117, Berlin, Germany.; Faculty of Medicine, University of Heidelberg, 69210, Heidelberg, Germany.
Poole E; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Hills Road, CB2 0SP, Cambridge, UK.; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.
Groves I; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Hills Road, CB2 0SP, Cambridge, UK.; Infection Biology, Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Owen DJ; Cambridge Institute for Medical Research, Keith Peters Building, Hills Road, Cambridge, CB2 0XY, UK. .
Graham SC; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK. .
Sinclair J; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Hills Road, CB2 0SP, Cambridge, UK. .
Kelly BT; Cambridge Institute for Medical Research, Keith Peters Building, Hills Road, Cambridge, CB2 0XY, UK. .
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Źródło:
EMBO reports [EMBO Rep] 2024 Mar; Vol. 25 (3), pp. 951-970. Date of Electronic Publication: 2024 Jan 29.
Typ publikacji:
Journal Article
MeSH Terms:
Proprotein Convertase 9*/metabolism
Serine Endopeptidases*
Humans ; Proprotein Convertases/metabolism ; Membrane Proteins ; Receptors, LDL/metabolism
Czasopismo naukowe
Tytuł:
Inhibition of proprotein convertases activity results in repressed stemness and invasiveness of cancer stem cells in gastric cancer.
Autorzy:
Zaafour A; BoRdeaux Institute of onCology (BRIC), INSERM U1312, Univ. Bordeaux, 33000, Bordeaux, France.
Seeneevassen L; BoRdeaux Institute of onCology (BRIC), INSERM U1312, Univ. Bordeaux, 33000, Bordeaux, France.
Nguyen TL; BoRdeaux Institute of onCology (BRIC), INSERM U1312, Univ. Bordeaux, 33000, Bordeaux, France.
Genevois C; BoRdeaux Institute of onCology (BRIC), INSERM U1312, Univ. Bordeaux, 33000, Bordeaux, France.; Vivoptic Platform, CNRS, INSERM TBM-Core UAR3427 US5, Univ. Bordeaux, 33000, Bordeaux, France.
Nicolas N; BoRdeaux Institute of onCology (BRIC), INSERM U1312, Univ. Bordeaux, 33000, Bordeaux, France.
Sifré E; BoRdeaux Institute of onCology (BRIC), INSERM U1312, Univ. Bordeaux, 33000, Bordeaux, France.
Giese A; BoRdeaux Institute of onCology (BRIC), INSERM U1312, Univ. Bordeaux, 33000, Bordeaux, France.
Porcheron C; BoRdeaux Institute of onCology (BRIC), INSERM U1312, Univ. Bordeaux, 33000, Bordeaux, France.
Descarpentrie J; BoRdeaux Institute of onCology (BRIC), INSERM U1312, Univ. Bordeaux, 33000, Bordeaux, France.
Dubus P; BoRdeaux Institute of onCology (BRIC), INSERM U1312, Univ. Bordeaux, 33000, Bordeaux, France.; Department of Histology and Pathology, CHU Bordeaux, 33000, Bordeaux, France.
Khatib AM; BoRdeaux Institute of onCology (BRIC), INSERM U1312, Univ. Bordeaux, 33000, Bordeaux, France.
Varon C; BoRdeaux Institute of onCology (BRIC), INSERM U1312, Univ. Bordeaux, 33000, Bordeaux, France. .
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Źródło:
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association [Gastric Cancer] 2024 Mar; Vol. 27 (2), pp. 292-307. Date of Electronic Publication: 2024 Jan 27.
Typ publikacji:
Journal Article
MeSH Terms:
Transcription Factors*/genetics
Stomach Neoplasms*/pathology
Humans ; Animals ; Mice ; YAP-Signaling Proteins ; Disease Models, Animal ; Proprotein Convertases/metabolism ; Neoplastic Stem Cells/metabolism
Czasopismo naukowe
Tytuł:
PCSK9 and leptin plasma levels in anorexia nervosa.
Autorzy:
Bigazzi F; U.O. Lipoapheresis and Center for Inherited Dyslipidemias, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
De Pasquale CF; Fondazione Stella Maris, IRCCS Istituto Scientifico per la Neuropsichiatria dell'Infanzia e dell'Adolescenza, Pisa, Italy.
Maestro S; Fondazione Stella Maris, IRCCS Istituto Scientifico per la Neuropsichiatria dell'Infanzia e dell'Adolescenza, Pisa, Italy.
Corciulo C; U.O. Lipoapheresis and Center for Inherited Dyslipidemias, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
Dal Pino B; U.O. Lipoapheresis and Center for Inherited Dyslipidemias, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
Sbrana F; U.O. Lipoapheresis and Center for Inherited Dyslipidemias, Fondazione Toscana Gabriele Monasterio, Pisa, Italy. .
Sampietro T; U.O. Lipoapheresis and Center for Inherited Dyslipidemias, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
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Źródło:
Hormones (Athens, Greece) [Hormones (Athens)] 2024 Mar; Vol. 23 (1), pp. 137-140. Date of Electronic Publication: 2023 Nov 24.
Typ publikacji:
Observational Study; Journal Article
MeSH Terms:
Proprotein Convertase 9*
Anorexia Nervosa*
Female ; Adolescent ; Humans ; Cholesterol, LDL ; Leptin ; Proprotein Convertases/metabolism ; Serine Endopeptidases/metabolism
Czasopismo naukowe
Tytuł:
Atherosclerosis and Toll-Like Receptor4 (TLR4), Lectin-Like Oxidized Low-Density Lipoprotein-1 (LOX-1), and Proprotein Convertase Subtilisin/Kexin Type9 (PCSK9).
Autorzy:
Bagheri B; Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran.; Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
Khatibiyan Feyzabadi Z; Student Research Committee, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Nouri A; Student Research Committee, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Azadfallah A; Student Research Committee, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Mahdizade Ari M; Student Research Committee, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Hemmati M; Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Darban M; Department of Internal Medicine, Kowsar Hospital, Semnan University of Medical Sciences, Semnan, Iran.
Alavi Toosi P; Student Research Committee, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Banihashemian SZ; Student Research Committee, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2024 Feb 27; Vol. 2024, pp. 5830491. Date of Electronic Publication: 2024 Feb 27 (Print Publication: 2024).
Typ publikacji:
Journal Article; Review
MeSH Terms:
Plaque, Atherosclerotic*
Atherosclerosis*
Humans ; Subtilisin ; Proprotein Convertase 9 ; Toll-Like Receptor 4 ; Lipoproteins, LDL ; Endothelial Cells ; Proprotein Convertases ; Lectins ; Scavenger Receptors, Class E
Czasopismo naukowe
Tytuł:
The Application of Peptide Nucleic Acids (PNA) in the Inhibition of Proprotein Convertase Subtilisin/Kexin 9 ( PCSK9 ) Gene Expression in a Cell-Free Transcription/Translation System.
Autorzy:
Polak A; Department of Internal Medicine and Clinical Pharmacology, Faculty of Medical Science in Katowice, Medical University of Silesia, Medykow 18, 40-752 Katowice, Poland.
Machnik G; Department of Internal Medicine and Clinical Pharmacology, Faculty of Medical Science in Katowice, Medical University of Silesia, Medykow 18, 40-752 Katowice, Poland.
Bułdak Ł; Department of Internal Medicine and Clinical Pharmacology, Faculty of Medical Science in Katowice, Medical University of Silesia, Medykow 18, 40-752 Katowice, Poland.
Ruczyński J; Laboratory of Chemistry of Biologically Active Compounds, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.
Prochera K; Laboratory of Chemistry of Biologically Active Compounds, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.
Bujak O; Laboratory of Chemistry of Biologically Active Compounds, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.
Mucha P; Laboratory of Chemistry of Biologically Active Compounds, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.
Rekowski P; Laboratory of Chemistry of Biologically Active Compounds, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.
Okopień B; Department of Internal Medicine and Clinical Pharmacology, Faculty of Medical Science in Katowice, Medical University of Silesia, Medykow 18, 40-752 Katowice, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 25; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 25.
Typ publikacji:
Journal Article
MeSH Terms:
Hypercholesterolemia*/drug therapy
Hypercholesterolemia*/genetics
Peptide Nucleic Acids*/pharmacology
PCSK9 Inhibitors*/pharmacology
Humans ; Gene Expression ; Proprotein Convertase 9/drug effects ; Proprotein Convertase 9/genetics ; Proprotein Convertases/genetics ; Receptors, LDL/genetics ; Receptors, LDL/metabolism ; Subtilisin/genetics
Czasopismo naukowe
Tytuł:
The Causal Relationship between PCSK9 Inhibitors and Malignant Tumors: A Mendelian Randomization Study Based on Drug Targeting.
Autorzy:
Wang W; Department of Pathology, Xinxiang Medical University, Xinxiang 453003, China.
Li W; School of Forensic Medicine, Xinxiang Medical University, Xinxiang 453003, China.
Zhang D; Department of Pathology, Xinxiang Medical University, Xinxiang 453003, China.
Mi Y; School of Forensic Medicine, Xinxiang Medical University, Xinxiang 453003, China.
Zhang J; Department of Pathology, Xinxiang Medical University, Xinxiang 453003, China.
He G; Department of Pathology, Xinxiang Medical University, Xinxiang 453003, China.
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Źródło:
Genes [Genes (Basel)] 2024 Jan 21; Vol. 15 (1). Date of Electronic Publication: 2024 Jan 21.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*
Lung Neoplasms*
Pharyngeal Neoplasms*
Carcinoma in Situ*
Female ; Humans ; Proprotein Convertase 9/genetics ; PCSK9 Inhibitors ; Subtilisin ; Mendelian Randomization Analysis ; Proprotein Convertases
Czasopismo naukowe
Tytuł:
The possible role furin and furin inhibitors in endometrial adenocarcinoma: A narrative review.
Autorzy:
Al-Kuraishy HM; Department of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq.
Al-Maiahy TJ; Department of Gynecology and Obstetrics, College of Medicine, Mustansiriyah University, Baghdad, Iraq.
Al-Gareeb AI; Department of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq.
Alexiou A; University Centre for Research & Development, Chandigarh University, Chandigarh-Ludhiana Highway, Mohali, Punjab, India.; Department of Research & Development, Funogen, Athens, Greece.; Department of Research & Development, AFNP Med, Wien, Austria.; Department of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, New South Wales, Australia.
Papadakis M; Department of Surgery II, University Hospital Witten-Herdecke, University of Witten-Herdecke, Wuppertal, Germany.
Saad HM; Department of Pathology, Faculty of Veterinary Medicine, Matrouh University, Matrouh, Egypt.
Batiha GE; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, AlBeheira, Egypt.
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Źródło:
Cancer reports (Hoboken, N.J.) [Cancer Rep (Hoboken)] 2024 Jan; Vol. 7 (1), pp. e1920. Date of Electronic Publication: 2023 Nov 28.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Furin*/genetics
Furin*/metabolism
Adenocarcinoma*
Humans ; Female ; Proprotein Convertases/metabolism ; Subtilisins/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł:
PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease.
Autorzy:
Sachan V; Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal (IRCM), affiliated to the Université de Montréal, Montréal, QC, Canada.
Le Dévéhat M; Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal (IRCM), affiliated to the Université de Montréal, Montréal, QC, Canada.
Roubtsova A; Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal (IRCM), affiliated to the Université de Montréal, Montréal, QC, Canada.
Essalmani R; Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal (IRCM), affiliated to the Université de Montréal, Montréal, QC, Canada.
Laurendeau JF; RNA and Noncoding Mechanisms of Disease, Institut de Recherches Cliniques de Montréal (IRCM), affiliated to the Université de Montréal, Montréal, QC, Canada.
Garçon D; Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal (IRCM), affiliated to the Université de Montréal, Montréal, QC, Canada.
Susan-Resiga D; Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal (IRCM), affiliated to the Université de Montréal, Montréal, QC, Canada.
Duval S; Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal (IRCM), affiliated to the Université de Montréal, Montréal, QC, Canada.
Mikaeeli S; Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal (IRCM), affiliated to the Université de Montréal, Montréal, QC, Canada.
Hamelin J; Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal (IRCM), affiliated to the Université de Montréal, Montréal, QC, Canada.
Evagelidis A; Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal (IRCM), affiliated to the Université de Montréal, Montréal, QC, Canada.
Chong M; Department of Biochemistry & Biomedical Sciences, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada.
Paré G; Department of Biochemistry & Biomedical Sciences, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada.
Chernetsova E; Department of Pathology, McGill University Health Centre, Montréal, QC, Canada.
Gao ZH; Department of Pathology, McGill University Health Centre, Montréal, QC, Canada.
Robillard I; Montreal Heart Institute, Metabolomics Platform, Montreal, Quebec, Canada; Department of Nutrition, Université de Montréal, Montréal, QC, Canada.
Ruiz M; Montreal Heart Institute, Metabolomics Platform, Montreal, Quebec, Canada; Department of Nutrition, Université de Montréal, Montréal, QC, Canada.
Trinh VQ; Departement of Pathology and Cellular Biology, Institut de Recherche en Immunologie et Cancérologie, Université de Montréal, Montréal, QC, Canada.
Estall JL; Molecular Mechanisms of Diabetes, Institut de Recherches Cliniques de Montréal (IRCM), affiliated to the Université de Montréal, Montréal, QC, Canada.
Faraj M; Nutrition Department, Université de Montréal, Research Unit on Nutrition, Lipoproteins and Cardiometabolic Diseases, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC, Canada.
Austin RC; Department of Medicine, Division of Nephrology, McMaster University, The Research Institute of St. Joe's Hamilton and the Hamilton Center for Kidney Research, Hamilton, ON, Canada.
Sauvageau M; RNA and Noncoding Mechanisms of Disease, Institut de Recherches Cliniques de Montréal (IRCM), affiliated to the Université de Montréal, Montréal, QC, Canada.
Prat A; Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal (IRCM), affiliated to the Université de Montréal, Montréal, QC, Canada.
Kiss RS; McGill University Health Centre Research Institute, Montréal, QC, Canada.
Seidah NG; Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal (IRCM), affiliated to the Université de Montréal, Montréal, QC, Canada. Electronic address: .
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Źródło:
Metabolism: clinical and experimental [Metabolism] 2024 Jan; Vol. 150, pp. 155736. Date of Electronic Publication: 2023 Nov 13.
Typ publikacji:
Journal Article
MeSH Terms:
Non-alcoholic Fatty Liver Disease*/genetics
Non-alcoholic Fatty Liver Disease*/metabolism
Mice ; Animals ; Subtilisin/metabolism ; Triglycerides/metabolism ; Liver/metabolism ; Apolipoproteins B/genetics ; Apolipoproteins B/metabolism ; Proprotein Convertases/metabolism ; Apolipoprotein B-100/genetics ; Apolipoprotein B-100/metabolism
Czasopismo naukowe
Tytuł:
PCSK6 exacerbates Alzheimer's disease pathogenesis by promoting MT5-MMP maturation.
Autorzy:
Xu M; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.
Li J; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Xia L; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Du Y; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Wu B; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Shi X; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Tian N; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Pang Y; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Yi L; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Chen M; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Song W; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Zhejiang Clinical Research Center for Mental Disorders, School of Mental Health and The Affiliated Kangning Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Dong Z; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. Electronic address: .
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Źródło:
Experimental neurology [Exp Neurol] 2024 Apr; Vol. 374, pp. 114688. Date of Electronic Publication: 2024 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Animals ; Humans ; Mice ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Disease Models, Animal ; Mice, Transgenic ; Proprotein Convertases/genetics ; Proprotein Convertases/metabolism ; Proteolysis ; Serine Endopeptidases/metabolism ; Spatial Learning
Czasopismo naukowe
Tytuł:
Design, synthesis, and characterization of novel fluorogenic substrates of the proprotein convertases furin, PC1/3, PC2, PC5/6, and PC7.
Autorzy:
Lam van TV; Institute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 6, D-35032, Marburg, Germany.
Ivanova T; Institute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 6, D-35032, Marburg, Germany.
Lindberg I; Department of Anatomy and Neurobiology, University of Maryland, Baltimore, MD, 21201, USA.
Böttcher-Friebertshäuser E; Institute of Virology, Philipps University, Hans-Meerwein-Straße 2, D-35043, Marburg, Germany.
Steinmetzer T; Institute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 6, D-35032, Marburg, Germany.
Hardes K; Institute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 6, D-35032, Marburg, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology, Ohlebergsweg 12, D-35392, Giessen, Germany. Electronic address: .
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Źródło:
Analytical biochemistry [Anal Biochem] 2022 Oct 15; Vol. 655, pp. 114836. Date of Electronic Publication: 2022 Aug 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Furin*
Proprotein Convertases*
Amino Acid Sequence ; Carbamates ; Fluorescent Dyes ; Oligopeptides ; Proteins ; Subtilisins/metabolism
Czasopismo naukowe
Tytuł:
Liver-Specific Ionizable Lipid Nanoparticles Mediated Efficient RNA Interference to Clear "Bad Cholesterol".
Autorzy:
Huang C; Department of Cardiology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, People's Republic of China.; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Zhang Y; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
Su J; Department of Cardiology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, People's Republic of China.; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Guan X; Department of Cardiology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, People's Republic of China.; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Chen S; Department of Cardiology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, People's Republic of China.; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Xu X; Department of Cardiology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, People's Republic of China.; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Deng X; Department of Cardiology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, People's Republic of China.; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Zhang L; Department of Cardiology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, People's Republic of China.; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Huang J; Department of Cardiology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, People's Republic of China.
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Źródło:
International journal of nanomedicine [Int J Nanomedicine] 2023 Dec 19; Vol. 18, pp. 7785-7801. Date of Electronic Publication: 2023 Dec 19 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Cardiovascular Diseases*/metabolism
Atherosclerosis*/metabolism
Nanoparticles*
Humans ; Proprotein Convertase 9/genetics ; Proprotein Convertase 9/metabolism ; Cholesterol, LDL/genetics ; Cholesterol, LDL/metabolism ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Proprotein Convertases/genetics ; Proprotein Convertases/metabolism ; RNA Interference ; Liver/metabolism ; Cholesterol ; Receptors, LDL/genetics ; Receptors, LDL/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism
Czasopismo naukowe

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