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Wyszukujesz frazę ""Prostaglandin-E Synthases"" wg kryterium: Temat


Tytuł :
Simple heteroaryl modifications in the 4,5-diarylisoxazol-3-carboxylic acid scaffold favorably modulates the activity as dual mPGES-1/5-LO inhibitors with in vivo efficacy.
Autorzy :
Gürses T; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Yenimahalle, 06560 Ankara, Turkey.
Olğaç A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Yenimahalle, 06560 Ankara, Turkey.
Garscha U; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, Philosophenweg 14, D-7743 Jena, Germany.
Gür Maz T; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Yenimahalle, 06560 Ankara, Turkey.
Bal NB; Department of Pharmacology, Faculty of Pharmacy, Gazi University, Yenimahalle, 06560 Ankara, Turkey.
Uludağ O; Department of Pharmacology, Faculty of Pharmacy, Gazi University, Yenimahalle, 06560 Ankara, Turkey.
Çalışkan B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Yenimahalle, 06560 Ankara, Turkey.
Schubert US; Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743 Jena, Germany; Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, D-07743 Jena, Germany.
Werz O; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, Philosophenweg 14, D-7743 Jena, Germany; Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743 Jena, Germany.
Banoglu E; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Yenimahalle, 06560 Ankara, Turkey. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Jul; Vol. 112, pp. 104861. Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Androstenols/*pharmacology
Arachidonate 5-Lipoxygenase/*metabolism
Carboxylic Acids/*pharmacology
Enzyme Inhibitors/*pharmacology
Prostaglandin-E Synthases/*antagonists & inhibitors
Adolescent ; Adult ; Aged ; Androstenols/chemical synthesis ; Androstenols/chemistry ; Carboxylic Acids/chemical synthesis ; Carboxylic Acids/chemistry ; Cell Line ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Healthy Volunteers ; Humans ; Middle Aged ; Molecular Structure ; Prostaglandin-E Synthases/metabolism ; Structure-Activity Relationship ; Young Adult
Czasopismo naukowe
Tytuł :
Discovery of N-amido-phenylsulfonamide derivatives as novel microsomal prostaglandin E 2 synthase-1 (mPGES-1) inhibitors.
Autorzy :
Kim M; Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Kim G; Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Kang M; Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Ko D; Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Nam Y; Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Moon CS; Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Kang HM; Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, Seoul 02447, Republic of Korea.
Shin JS; Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
Werz O; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, Philosophenweg 14, 07743 Jena, Germany.
Lee KT; Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address: .
Lee JY; Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, Seoul 02447, Republic of Korea; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Jun 01; Vol. 41, pp. 127992. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
Enzyme Inhibitors/*pharmacology
Prostaglandin-E Synthases/*antagonists & inhibitors
Sulfonamides/*pharmacology
A549 Cells ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Liver/chemistry ; Liver/metabolism ; Molecular Docking Simulation ; Molecular Structure ; Prostaglandin-E Synthases/metabolism ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry
Czasopismo naukowe
Tytuł :
Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity.
Autorzy :
Ochiai T; Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan.
Sasaki Y; Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan.
Kuwata H; Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan.
Nakatani Y; Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan.
Yokoyama C; Kanagawa Institute of Technology, Atsugi, Kanagawa, Japan.
Hara S; Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Mar 26; Vol. 546, pp. 124-129. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytochrome P-450 Enzyme System/*metabolism
Dermatitis, Contact/*enzymology
Intramolecular Oxidoreductases/*metabolism
Prostaglandin-E Synthases/*metabolism
Adoptive Transfer ; Animals ; Bone Marrow Cells ; Cytochrome P-450 Enzyme System/deficiency ; Cytochrome P-450 Enzyme System/genetics ; Dermatitis, Contact/etiology ; Dermatitis, Contact/genetics ; Dinitrofluorobenzene/adverse effects ; Ear/pathology ; Female ; Interferon-gamma/metabolism ; Interleukins/metabolism ; Intramolecular Oxidoreductases/deficiency ; Intramolecular Oxidoreductases/genetics ; Mice ; Mice, Knockout ; Prostaglandin-E Synthases/deficiency ; Prostaglandin-E Synthases/genetics ; Prostaglandins/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Gene Deletion of Microsomal Prostaglandin E Synthase-1 Suppresses Chemically Induced Skin Carcinogenesis.
Autorzy :
Sasaki Y; Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan.
Kuwata H; Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan.
Aida E; Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan.
Ochiai T; Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan.
Kamei D; Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan.
Nakatani Y; Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan.
Hara S; Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan .
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Źródło :
Anticancer research [Anticancer Res] 2021 Mar; Vol. 41 (3), pp. 1307-1314.
Typ publikacji :
Journal Article
MeSH Terms :
Prostaglandin-E Synthases/*physiology
Skin Neoplasms/*prevention & control
9,10-Dimethyl-1,2-benzanthracene ; Animals ; Apoptosis/drug effects ; Cyclooxygenase 2/genetics ; Cytokines/biosynthesis ; Dinoprostone/analysis ; Mice ; Mice, Inbred BALB C ; Prostaglandin-E Synthases/deficiency ; Prostaglandin-E Synthases/genetics ; Skin Neoplasms/chemically induced ; Tetradecanoylphorbol Acetate
Czasopismo naukowe
Tytuł :
Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle.
Autorzy :
Biebl MM; Department of Chemistry, Technische Universität München, Garching, Germany.
Lopez A; Department of Chemistry, Technische Universität München, Garching, Germany.; Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany.
Rehn A; Department of Chemistry, Technische Universität München, Garching, Germany.; Institut für Mikrobiologie der Bundeswehr, München, Germany.
Freiburger L; Department of Chemistry, Technische Universität München, Garching, Germany.; Zymeworks Inc., Vancouver, BC, Canada.
Lawatscheck J; Department of Chemistry, Technische Universität München, Garching, Germany.
Blank B; Department of Chemistry, Technische Universität München, Garching, Germany.; C5 Department of Cell and Molecular Biology, CMB Farnebo, Stockholm, Sweden.
Sattler M; Department of Chemistry, Technische Universität München, Garching, Germany. .; Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany. .
Buchner J; Department of Chemistry, Technische Universität München, Garching, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 05; Vol. 12 (1), pp. 828. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenylyl Imidodiphosphate/*chemistry
HSP90 Heat-Shock Proteins/*chemistry
Molecular Chaperones/*chemistry
Prostaglandin-E Synthases/*chemistry
Receptors, Glucocorticoid/*chemistry
Saccharomyces cerevisiae/*chemistry
Saccharomyces cerevisiae Proteins/*chemistry
Adenylyl Imidodiphosphate/metabolism ; Amino Acid Sequence ; Binding Sites ; Cloning, Molecular ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; HSP90 Heat-Shock Proteins/genetics ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Molecular Dynamics Simulation ; Mutation ; Nuclear Magnetic Resonance, Biomolecular ; Prostaglandin-E Synthases/genetics ; Prostaglandin-E Synthases/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Receptors, Glucocorticoid/genetics ; Receptors, Glucocorticoid/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid
Czasopismo naukowe
Tytuł :
Investigation of the Substrate-Binding Site of a Prostaglandin E Synthase in Bombyx mori.
Autorzy :
Yamamoto K; Department of Bioscience and Biotechnology, Kyushu University Graduate School, 744 Motooka, Nishi-ku, Fukuoka, 819- 0395, Fukuoka, Japan. .
Hirowatari A; Department of Bioscience and Biotechnology, Kyushu University Graduate School, 744 Motooka, Nishi-ku, Fukuoka, 819- 0395, Fukuoka, Japan.
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Źródło :
The protein journal [Protein J] 2021 Feb; Vol. 40 (1), pp. 63-67. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bombyx/*chemistry
Dinoprostone/*chemistry
Glutathione/*chemistry
Insect Proteins/*chemistry
Prostaglandin-E Synthases/*chemistry
Amino Acid Motifs ; Animals ; Bombyx/enzymology ; Catalytic Domain ; Cloning, Molecular ; Crystallography, X-Ray ; Dinitrochlorobenzene/chemistry ; Dinitrochlorobenzene/metabolism ; Dinoprostone/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Glutathione/metabolism ; Insect Proteins/genetics ; Insect Proteins/metabolism ; Models, Molecular ; Mutagenesis, Site-Directed ; Mutation ; Prostaglandin-E Synthases/genetics ; Prostaglandin-E Synthases/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Structure, Secondary ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Structure-Activity Relationship ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Up-regulation of cytosolic prostaglandin E synthase in fetal-membrane and amniotic prostaglandin E2 accumulation in labor.
Autorzy :
Takahashi N; Department of Biochemistry, Juntendo University School of Medicine, Tokyo, Japan.; Department of Obstetrics & Gynecology, Juntendo University School of Medicine, Tokyo, Japan.
Okuno T; Department of Biochemistry, Juntendo University School of Medicine, Tokyo, Japan.
Fujii H; Department of Biochemistry, Juntendo University School of Medicine, Tokyo, Japan.
Makino S; Department of Obstetrics & Gynecology, Juntendo University Urayasu Hospital, Chiba, Japan.
Takahashi M; Department of Obstetrics & Gynecology, Juntendo University Urayasu Hospital, Chiba, Japan.
Ohba M; Department of Biochemistry, Juntendo University School of Medicine, Tokyo, Japan.
Saeki K; Department of Biochemistry, Juntendo University School of Medicine, Tokyo, Japan.
Itakura A; Department of Obstetrics & Gynecology, Juntendo University School of Medicine, Tokyo, Japan.
Takeda S; Department of Obstetrics & Gynecology, Juntendo University School of Medicine, Tokyo, Japan.
Yokomizo T; Department of Biochemistry, Juntendo University School of Medicine, Tokyo, Japan.
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Źródło :
PloS one [PLoS One] 2021 Apr 23; Vol. 16 (4), pp. e0250638. Date of Electronic Publication: 2021 Apr 23 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amnion/*metabolism
Dinoprostone/*metabolism
Extraembryonic Membranes/*metabolism
Labor, Obstetric/*metabolism
Prostaglandin-E Synthases/*metabolism
Amniotic Fluid/metabolism ; Chromatography, High Pressure Liquid ; Cyclooxygenase 1/genetics ; Cyclooxygenase 1/metabolism ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2/metabolism ; Dinoprostone/analysis ; Extraembryonic Membranes/pathology ; Female ; Humans ; Organic Anion Transporters/genetics ; Organic Anion Transporters/metabolism ; Pregnancy ; Prostaglandin-E Synthases/genetics ; RNA, Messenger/metabolism ; Tandem Mass Spectrometry ; Up-Regulation
Czasopismo naukowe
Tytuł :
Roles of three putative salmon louse (Lepeophtheirus salmonis) prostaglandin E 2 synthases in physiology and host-parasite interactions.
Autorzy :
Dalvin S; Institute of Marine Research, SLCR-Sea Lice Research Centre, Nordnes, P. box 1870, 5817, Bergen, Norway.
Eichner C; Department of Biological Sciences, SLCR-Sea Lice Research Centre, University of Bergen, P. box 7803, 5020, Bergen, Norway.
Dondrup M; Department of Informatics, SLRC-Sea Lice Research Centre, University of Bergen, P. box 7803, 5020, Bergen, Norway.
Øvergård AC; Department of Biological Sciences, SLCR-Sea Lice Research Centre, University of Bergen, P. box 7803, 5020, Bergen, Norway. .
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Źródło :
Parasites & vectors [Parasit Vectors] 2021 Apr 19; Vol. 14 (1), pp. 206. Date of Electronic Publication: 2021 Apr 19.
Typ publikacji :
Journal Article
MeSH Terms :
Arthropod Proteins/*metabolism
Copepoda/*enzymology
Fish Diseases/*parasitology
Prostaglandin-E Synthases/*metabolism
Animals ; Arthropod Proteins/genetics ; Copepoda/classification ; Copepoda/genetics ; Copepoda/growth & development ; Female ; Host-Parasite Interactions ; Male ; Phylogeny ; Prostaglandin-E Synthases/genetics ; Prostaglandins/metabolism ; Salmo salar/parasitology
Czasopismo naukowe
Tytuł :
Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression.
Autorzy :
Rappl P; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.
Rösser S; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.
Maul P; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.
Bauer R; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.
Huard A; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.
Schreiber Y; Fraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt, Germany.
Thomas D; Institute of Clinical Pharmacology, pharmazentrum Frankfurt/ZAFES, University Hospital, Goethe-University Frankfurt, Frankfurt, Germany.
Geisslinger G; Fraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt, Germany.; Institute of Clinical Pharmacology, pharmazentrum Frankfurt/ZAFES, University Hospital, Goethe-University Frankfurt, Frankfurt, Germany.
Jakobsson PJ; Rheumatology Unit, Dep. of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Weigert A; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.
Brüne B; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany. .; Fraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt, Germany. .; German Cancer Consortium (DKTK), Partner Site Frankfurt, Frankfurt, Germany. .; Frankfurt Cancer Institute, Goethe-University Frankfurt, Frankfurt, Germany. .
Schmid T; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany. .
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Źródło :
Cell death & disease [Cell Death Dis] 2021 Feb 02; Vol. 12 (2), pp. 135. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chemokine CX3CL1/*metabolism
Dinoprostone/*metabolism
Enzyme Inhibitors/*pharmacology
Epithelial Cells/*metabolism
Macrophages, Peritoneal/*drug effects
Peritonitis/*enzymology
Prostaglandin-E Synthases/*antagonists & inhibitors
Animals ; Antibodies, Neutralizing/pharmacology ; CX3C Chemokine Receptor 1/genetics ; CX3C Chemokine Receptor 1/metabolism ; Cell Adhesion ; Cell Survival ; Cells, Cultured ; Chemokine CX3CL1/antagonists & inhibitors ; Chemokine CX3CL1/genetics ; Disease Models, Animal ; Epithelial Cells/drug effects ; Female ; Macrophages, Peritoneal/enzymology ; Macrophages, Peritoneal/immunology ; Mice, Inbred C57BL ; Neutrophil Infiltration ; Peritonitis/genetics ; Peritonitis/immunology ; Phenotype ; Prostaglandin-E Synthases/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP).
Autorzy :
Ho JD; Lilly Biotechnology Center, San Diego, CA 92121, USA. Electronic address: .
Lee MR; Lilly Biotechnology Center, San Diego, CA 92121, USA.
Rauch CT; Lilly Biotechnology Center, San Diego, CA 92121, USA.
Aznavour K; Lilly Biotechnology Center, San Diego, CA 92121, USA.
Park JS; Lilly Biotechnology Center, San Diego, CA 92121, USA.
Luz JG; Lilly Biotechnology Center, San Diego, CA 92121, USA.
Antonysamy S; Lilly Biotechnology Center, San Diego, CA 92121, USA.
Condon B; Lilly Biotechnology Center, San Diego, CA 92121, USA.
Maletic M; Lilly Biotechnology Center, San Diego, CA 92121, USA.
Zhang A; Lilly Biotechnology Center, San Diego, CA 92121, USA.
Hickey MJ; Lilly Biotechnology Center, San Diego, CA 92121, USA.
Hughes NE; Lilly Biotechnology Center, San Diego, CA 92121, USA.
Chandrasekhar S; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
Sloan AV; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
Gooding K; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
Harvey A; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
Yu XP; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
Kahl SD; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
Norman BH; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA. Electronic address: .
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Źródło :
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2021 Feb; Vol. 1865 (2), pp. 129800. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Drug Discovery*
5-Lipoxygenase-Activating Protein Inhibitors/*pharmacology
Eicosanoids/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Prostaglandin-E Synthases/*antagonists & inhibitors
5-Lipoxygenase-Activating Protein Inhibitors/chemistry ; 5-Lipoxygenase-Activating Proteins/metabolism ; Eicosanoids/metabolism ; Enzyme Inhibitors/chemistry ; Humans ; Models, Molecular ; Prostaglandin-E Synthases/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
What about COVID-19 and arachidonic acid pathway?
Autorzy :
Hoxha M; Department of Chemical-Toxicological and Pharmacological Evaluations of Drugs, Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, Rruga Dritan Hoxha, Tirana, Albania. .
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Źródło :
European journal of clinical pharmacology [Eur J Clin Pharmacol] 2020 Nov; Vol. 76 (11), pp. 1501-1504. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Arachidonic Acid/*biosynthesis
Coronavirus Infections/*physiopathology
Cyclooxygenase 2/*biosynthesis
Inflammation/*metabolism
Pneumonia, Viral/*physiopathology
Prostaglandin-E Synthases/*biosynthesis
Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Betacoronavirus ; COVID-19 ; Cyclooxygenase 2/blood ; Humans ; Pandemics ; Phospholipases A2/biosynthesis ; Prostaglandin-E Synthases/blood ; Prostaglandins/biosynthesis ; Prostaglandins/blood ; Protein-Lysine 6-Oxidase/biosynthesis ; SARS-CoV-2 ; Sex Factors
Czasopismo naukowe
Tytuł :
Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis.
Autorzy :
Kirkby NS; National Heart & Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK.
Raouf J; Unit of Rheumatology, Department of Medicine, Karolinska Institute, Stockholm, Sweden.
Ahmetaj-Shala B; National Heart & Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK.
Liu B; Cardiovascular Research Centre, Shantou University Medical College, Shantou, China.
Mazi SI; National Heart & Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK.; King Fahad Cardiac Center, King Saud University, Riyadh, Saudi Arabia.
Edin ML; National Institute for Environmental Health Sciences, Durham, NC, USA.
Chambers MG; Biotechnology and Autoimmunity Research, Eli Lilly and Company, Indianapolis, IN, USA.
Korotkova M; Unit of Rheumatology, Department of Medicine, Karolinska Institute, Stockholm, Sweden.
Wang X; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.; Institute of Molecular and Cell Biology, Agency for Science Technology & Research, Singapore, Singapore.; Department of Cell Biology, Institute of Ophthalmology, University College London, London, UK.; Singapore Eye Research Institute, Singapore, Singapore.
Wahli W; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Zeldin DC; National Institute for Environmental Health Sciences, Durham, NC, USA.
Nüsing R; Clinical Pharmacology and Pharmacotherapy Department, Goethe University, Frankfurt, Germany.
Zhou Y; Cardiovascular Research Centre, Shantou University Medical College, Shantou, China.
Jakobsson PJ; Unit of Rheumatology, Department of Medicine, Karolinska Institute, Stockholm, Sweden.; Karolinska University Hospital, Stockholm, Sweden.
Mitchell JA; National Heart & Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK.
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Źródło :
Cardiovascular research [Cardiovasc Res] 2020 Oct 01; Vol. 116 (12), pp. 1972-1980.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aorta/*enzymology
Arginine/*analogs & derivatives
Cyclooxygenase 2/*metabolism
Kidney/*enzymology
Prostaglandin-E Synthases/*metabolism
Animals ; Aorta/drug effects ; Arginine/blood ; Cyclooxygenase 2 Inhibitors/pharmacology ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Female ; Intramolecular Oxidoreductases/genetics ; Intramolecular Oxidoreductases/metabolism ; Kidney/drug effects ; Male ; Mice, Knockout ; PPAR-beta/genetics ; PPAR-beta/metabolism ; Prostaglandin-E Synthases/antagonists & inhibitors ; Prostaglandin-E Synthases/genetics ; Prostaglandins I/blood ; Receptors, Cytoplasmic and Nuclear/genetics ; Receptors, Cytoplasmic and Nuclear/metabolism ; Receptors, Epoprostenol/genetics ; Receptors, Epoprostenol/metabolism ; Receptors, Prostaglandin E/genetics ; Receptors, Prostaglandin E/metabolism
Czasopismo naukowe
Tytuł :
[Research advances of prostaglandin E 2 synthases and receptors in cardiovascular diseases].
Autorzy :
Liu M; Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China.
Guo MN; Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China.
Chen LH; Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China. .
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Źródło :
Sheng li xue bao : [Acta physiologica Sinica] [Sheng Li Xue Bao] 2021 Aug 25; Vol. 73 (4), pp. 665-680.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cardiovascular Diseases*/drug therapy
Anti-Inflammatory Agents, Non-Steroidal ; Cyclooxygenase 2 ; Dinoprostone ; Humans ; Prostaglandin-E Synthases ; Receptors, Prostaglandin E
Czasopismo naukowe
Tytuł :
Modulation of the PGE 2 -Mediated Pathway in the Eclosion Blocking Effect of Flumethrin and Terpenoid Subfraction Isolated from Artemesia nilagirica in Rhipicephalus annulatus .
Autorzy :
Ramachandran PD; Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Pookode, Kerala Veterinary and Animal Sciences University, Lakkidi, P. O., Wayanad 673576, Kerala, India.
Muniyappa MD; Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Pookode, Kerala Veterinary and Animal Sciences University, Lakkidi, P. O., Wayanad 673576, Kerala, India.
Kanapadinchareveetil S; Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Pookode, Kerala Veterinary and Animal Sciences University, Lakkidi, P. O., Wayanad 673576, Kerala, India.
Nair SN; Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Pookode, Kerala Veterinary and Animal Sciences University, Lakkidi, P. O., Wayanad 673576, Kerala, India.
Ajithkumar KG; Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, Pookode, Kerala Veterinary and Animal Sciences University, Lakkidi, P. O., Wayanad 673576, Kerala, India.
Samraj S; Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Pookode, Kerala Veterinary and Animal Sciences University, Lakkidi, P. O., Wayanad 673576, Kerala, India.
Rajappan A; Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Pookode, Kerala Veterinary and Animal Sciences University, Lakkidi, P. O., Wayanad 673576, Kerala, India.
Varghese A; Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, Pookode, Kerala Veterinary and Animal Sciences University, Lakkidi, P. O., Wayanad 673576, Kerala, India.
Kalarickal DC; Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, Pookode, Kerala Veterinary and Animal Sciences University, Lakkidi, P. O., Wayanad 673576, Kerala, India.
Ravindran R; Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, Pookode, Kerala Veterinary and Animal Sciences University, Lakkidi, P. O., Wayanad 673576, Kerala, India.
Ghosh S; Division of Parasitology, ICAR-Indian Veterinary Research Institute, Izatnagar 243122, Bareilly, India.
Juliet S; Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Pookode, Kerala Veterinary and Animal Sciences University, Lakkidi, P. O., Wayanad 673576, Kerala, India.; Center for Ethnopharmacology, College of Veterinary and Animal Sciences, Pookode, Kerala Veterinary and Animal Sciences University, Lakkidi, P. O., Wayanad 673576, Kerala, India.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Aug 13; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 13.
Typ publikacji :
Journal Article
MeSH Terms :
Artemisia/*chemistry
Dinoprostone/*metabolism
Pyrethrins/*pharmacology
Rhipicephalus/*drug effects
Terpenes/*isolation & purification
Terpenes/*pharmacology
Animals ; Antibodies/metabolism ; Female ; Gas Chromatography-Mass Spectrometry ; Hemolymph/metabolism ; Immersion ; Ovary/drug effects ; Ovary/enzymology ; Peroxidase/metabolism ; Prostaglandin-E Synthases/metabolism ; Vitellogenins/metabolism
Czasopismo naukowe
Tytuł :
Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice.
Autorzy :
Gurusamy M; Department of BIN Convergence Technology, Chonbuk National University, Jeonju, South Korea.
Nasseri S; Department of BIN Convergence Technology, Chonbuk National University, Jeonju, South Korea.; Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Rampa DR; Department of BIN Convergence Technology, Chonbuk National University, Jeonju, South Korea.
Feng H; Department of BIN Convergence Technology, Chonbuk National University, Jeonju, South Korea.
Lee D; Department of BIN Convergence Technology, Chonbuk National University, Jeonju, South Korea. .
Pekcec A; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany.
Doods H; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany.
Wu D; Department of BIN Convergence Technology, Chonbuk National University, Jeonju, South Korea. .; Department of Research, Mount Sinai Medical Center, Miami Beach, FL, USA. .
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Źródło :
Journal of translational medicine [J Transl Med] 2021 Aug 09; Vol. 19 (1), pp. 340. Date of Electronic Publication: 2021 Aug 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acute Lung Injury*/drug therapy
Sepsis*
Animals ; Cyclooxygenase 2/metabolism ; Dinoprostone ; Disease Models, Animal ; Humans ; Lung/metabolism ; Mice ; Nitric Oxide Synthase Type II ; Prostaglandin-E Synthases/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Biochemical properties of human full-length aryl hydrocarbon receptor (AhR).
Autorzy :
Uemura S; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Nakajima Y; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Yoshida Y; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Furuya M; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Matsutani S; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Kawate S; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Ikeda SI; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Tsuji N; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Grave E; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Wakui H; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
Itoh H; Department of Life Science, Graduate School and Faculty of Engineering Science, Akita University, Akita 010-8502, Japan.
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Źródło :
Journal of biochemistry [J Biochem] 2020 Sep 01; Vol. 168 (3), pp. 285-294.
Typ publikacji :
Journal Article
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*chemistry
Basic Helix-Loop-Helix Transcription Factors/*metabolism
HSP90 Heat-Shock Proteins/*metabolism
Nuclear Proteins/*metabolism
Prostaglandin-E Synthases/*metabolism
Receptors, Aryl Hydrocarbon/*chemistry
Receptors, Aryl Hydrocarbon/*metabolism
Trans-Activators/*metabolism
Antibodies/immunology ; Basic Helix-Loop-Helix Transcription Factors/immunology ; Basic Helix-Loop-Helix Transcription Factors/isolation & purification ; Escherichia coli/genetics ; Escherichia coli/metabolism ; HSP90 Heat-Shock Proteins/immunology ; HeLa Cells ; Humans ; Ligands ; Nuclear Proteins/immunology ; Prostaglandin-E Synthases/immunology ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Receptors, Aryl Hydrocarbon/immunology ; Receptors, Aryl Hydrocarbon/isolation & purification ; Trans-Activators/immunology
Czasopismo naukowe
Tytuł :
Polysubstituted Pyrimidines as mPGES-1 Inhibitors: Discovery of Potent Inhibitors of PGE 2 Production with Strong Anti-inflammatory Effects in Carrageenan-Induced Rat Paw Edema.
Autorzy :
Kalčic F; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 166 10, Prague 6, Czech Republic.; Department of Organic Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 43, Prague 2, Czech Republic.
Kolman V; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 166 10, Prague 6, Czech Republic.
Ajani H; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 166 10, Prague 6, Czech Republic.
Zídek Z; Institute of Experimental Medicine of the Czech Academy of Sciences, Vídeňská 1083, 142 20, Prague 4, Czech Republic.
Janeba Z; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 166 10, Prague 6, Czech Republic.
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Źródło :
ChemMedChem [ChemMedChem] 2020 Aug 05; Vol. 15 (15), pp. 1398-1407. Date of Electronic Publication: 2020 Jun 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Dinoprostone/*antagonists & inhibitors
Edema/*drug therapy
Prostaglandin-E Synthases/*antagonists & inhibitors
Pyrimidines/*pharmacology
Administration, Oral ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Carrageenan ; Cell Line ; Cell Survival/drug effects ; Dinoprostone/biosynthesis ; Dose-Response Relationship, Drug ; Drug Discovery ; Edema/chemically induced ; Humans ; Mice ; Molecular Structure ; Prostaglandin-E Synthases/metabolism ; Pyrimidines/administration & dosage ; Pyrimidines/chemistry ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Crosstalk between the COX2-PGE2-EP4 signaling pathway and primary cilia in osteoblasts after mechanical stimulation.
Autorzy :
Li YH; Department of Cardiology and Echocardiography, The First Hospital of Jilin University, Changchun, China.
Zhu D; Department of Orthopedic Trauma, The First Hospital of Jilin University, Changchun, China.
Yang T; Department of Plastic and Cosmetic Surgery, The First Hospital of Jilin University, Changchun, China.
Cheng L; Department of Orthopedic Trauma, The First Hospital of Jilin University, Changchun, China.
Sun J; Department of Cardiology, The First Hospital of Jilin University, Changchun, China.
Tan L; Department of Orthopedic Trauma, The First Hospital of Jilin University, Changchun, China.
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Źródło :
Journal of cellular physiology [J Cell Physiol] 2021 Jun; Vol. 236 (6), pp. 4764-4777. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*/drug effects
Mechanotransduction, Cellular*
Osteogenesis*/drug effects
Cilia/*enzymology
Cyclooxygenase 2/*metabolism
Dinoprostone/*metabolism
Osteoblasts/*enzymology
Receptors, Prostaglandin E, EP4 Subtype/*metabolism
3T3 Cells ; Animals ; Cilia/drug effects ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2 Inhibitors/pharmacology ; Mice ; Osteoblasts/drug effects ; Physical Stimulation ; Prostaglandin Antagonists/pharmacology ; Prostaglandin-E Synthases/genetics ; Prostaglandin-E Synthases/metabolism ; Receptors, Prostaglandin E, EP4 Subtype/antagonists & inhibitors ; Receptors, Prostaglandin E, EP4 Subtype/genetics ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Vibration
Czasopismo naukowe
Tytuł :
DREAM-in-CDM Approach and Identification of a New Generation of Anti-inflammatory Drugs Targeting mPGES-1.
Autorzy :
Zhou S; Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA.
Zhou Z; Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA.
Ding K; Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA.
Yuan Y; Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA.
Loftin C; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA.
Zheng F; Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. .; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. .
Zhan CG; Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. .; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jun 23; Vol. 10 (1), pp. 10187. Date of Electronic Publication: 2020 Jun 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Drug Repositioning*
Anti-Inflammatory Agents/*pharmacology
Coronavirus Infections/*drug therapy
Lapatinib/*pharmacology
Pneumonia, Viral/*drug therapy
Prostaglandin-E Synthases/*antagonists & inhibitors
Betacoronavirus ; COVID-19 ; Computational Chemistry/methods ; Coronavirus Infections/pathology ; Cyclooxygenase 1/metabolism ; Cyclooxygenase 2/metabolism ; Cyclooxygenase Inhibitors/pharmacology ; Humans ; Inflammation/drug therapy ; Molecular Dynamics Simulation ; Pandemics ; Pneumonia, Viral/pathology ; Prostaglandin-E Synthases/metabolism ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Ellagitannins from Punica granatum leaves suppress microsomal prostaglandin E synthase-1 expression and induce lung cancer cells to undergo apoptosis.
Autorzy :
Toda K; Department of Nutritional Science, Okayama Prefectural University, Okayama, Japan.
Ueyama M; Department of Nutritional Science, Okayama Prefectural University, Okayama, Japan.
Tanaka S; Department of Nutritional Science, Okayama Prefectural University, Okayama, Japan.
Tsukayama I; Department of Nutritional Science, Okayama Prefectural University, Okayama, Japan.
Mega T; Department of Nutritional Science, Okayama Prefectural University, Okayama, Japan.
Konoike Y; Department of Nutritional Science, Okayama Prefectural University, Okayama, Japan.
Tamenobu A; Department of Nutritional Science, Okayama Prefectural University, Okayama, Japan.
Bastian F; Department of Nutritional Science, Okayama Prefectural University, Okayama, Japan.
Akai I; Department of Nutritional Science, Okayama Prefectural University, Okayama, Japan.
Ito H; Department of Nutritional Science, Okayama Prefectural University, Okayama, Japan.
Kawakami Y; Department of Nutritional Science, Okayama Prefectural University, Okayama, Japan.
Takahashi Y; Department of Nutritional Science, Okayama Prefectural University, Okayama, Japan.
Suzuki-Yamamoto T; Department of Nutritional Science, Okayama Prefectural University, Okayama, Japan.
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Źródło :
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2020 Apr; Vol. 84 (4), pp. 757-763. Date of Electronic Publication: 2019 Dec 22.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Hydrolyzable Tannins/*pharmacology
Lung Neoplasms/*pathology
Plant Leaves/*chemistry
Pomegranate/*chemistry
Prostaglandin-E Synthases/*antagonists & inhibitors
A549 Cells ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2/metabolism ; Humans ; Prostaglandin-E Synthases/genetics ; Prostaglandin-E Synthases/metabolism ; RNA, Messenger/genetics
Czasopismo naukowe

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