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Podgląd okładki
Tytuł :
Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence
Autorzy :
Revandkar, Ajinkya
Perciato, Maria Luna
Toso, Alberto
Alajati, Abdullah
Chen, Jingjing
Gerber, Hermeto
Dimitrov, Mitko
Rinaldi, Andrea
Delaleu, Nicolas
Pasquini, Emiliano
D'Antuono, Rocco
Pinton, Sandra
Losa, Marco
Gnetti, Letizia
Arribas, Alberto
Fraering, Patrick
Bertoni, Francesco
Nepveu, Alain
Alimonti, Andrea
Pokaż więcej
Temat :
ADAM17 Protein/genetics
ADAM17 Protein/metabolism
Amyloid Precursor Protein Secretases/antagonists & inhibitors
Animals
Cell Line, Tumor
Cellular Senescence/drug effects
Cyclin-Dependent Kinase Inhibitor p27/metabolism
Cyclin-Dependent Kinase Inhibitor p27/physiology
Humans
Male
Mice
PTEN Phosphohydrolase/genetics
PTEN Phosphohydrolase/metabolism
Prostatic Neoplasms/drug therapy
Prostatic Neoplasms/pathology
Receptors, Notch/antagonists & inhibitors
Receptors, Notch/metabolism
Signal Transduction/drug effects
Tetrahydronaphthalenes/therapeutic use
Up-Regulation
Valine/analogs & derivatives
Valine/therapeutic use
Article
Źródło :
Nature communications, vol. 7, pp. 13719
Opis pliku :
application/pdf
Szczegóły
Podgląd okładki
Tytuł :
TMPRSS2:ERG gene fusion expression regulates bone markers and enhances the osteoblastic phenotype of prostate cancer bone metastases
Autorzy :
Delliaux, Carine
Tian, Tian
Bouchet, Mathilde
Fradet, Anaïs
Vanpouille, Nathalie
Flourens, Anne
Deplus, Rachel
Villers, Arnauld
Leroy, Xavier
Clézardin, Philippe
de Launoit, Yvan
Bonnelye, Edith
Duterque-Coquillaud, Martine
Pokaż więcej
Temat :
MESH: Animals
MESH: Oncogene Proteins, Fusion/metabolism
MESH: Male
Transcriptional regulation
MESH: Alkaline Phosphatase/genetics
MESH: Osteoblasts/pathology
MESH: Osteoblasts/metabolism
MESH: Transplantation, Heterologous
MESH: Tumor Burden/genetics
Osteoblastic lesions
MESH: Phenotype
[SDV.CAN]Life Sciences [q-bio]/Cancer
MESH: Bone Neoplasms/secondary
MESH: Prostatic Neoplasms/pathology
MESH: Bone Neoplasms/genetics
MESH: Prostatic Neoplasms/metabolism
MESH: Mice, SCID
MESH: Biomarkers, Tumor/genetics
Bone metastasis
urologic and male genital diseases
MESH: Humans
MESH: Alkaline Phosphatase/metabolism
MESH: Biomarkers, Tumor/metabolism
MESH: Bone Neoplasms/metabolism
Prostate cancer
MESH: Oncogene Proteins, Fusion/genetics
TMPRSS2:ERG
Fusion gene
MESH: Gene Expression Regulation, Neoplastic
MESH: Endothelin-1/genetics
[SDV]Life Sciences [q-bio]
MESH: PC-3 Cells
MESH: Prostatic Neoplasms/genetics
MESH: Endothelin-1/metabolism
MESH: Cell Line, Tumor
Źródło :
Cancer Letters, Elsevier, 2018, 438, pp.32-43. ⟨10.1016/j.canlet.2018.08.027⟩
Szczegóły
Podgląd okładki
Tytuł :
Contouring of prostate tumors on multiparametric MRI : Evaluation of clinical delineations in a multicenter radiotherapy trial
Autorzy :
van Schie, Marcel A
Dinh, Cuong V
Houdt, Petra J van
Pos, Floris J
Heijmink, Stijn W T J P
Kerkmeijer, Linda G W
Kotte, Alexis N T J
Oyen, Raymond
Haustermans, Karin
van der Heide, Uulke A
Pokaż więcej
Temat :
Aged
Aged, 80 and over
Area Under Curve
Humans
Magnetic Resonance Imaging/methods
Male
Middle Aged
Neoplasm Grading
Prostatic Neoplasms/pathology
ROC Curve
Tumor delineation
Multiparametric MRI
FLAME
Multicenter trial
Prostate cancer
Hematology
Oncology
Radiology Nuclear Medicine and imaging
Research Support, Non-U.S. Gov't
Randomized Controlled Trial
Multicenter Study
Clinical Trial, Phase III
Journal Article
Źródło :
Radiotherapy & Oncology, 128(2), 321. Elsevier Ireland Ltd
Opis pliku :
image/pdf
Szczegóły
Podgląd okładki
Tytuł :
A modeling study of functional magnetic resonance imaging to individualize target definition of seminal vesicles for external beam radiotherapy.
Autorzy :
Damkjær, Sidsel
Thomsen, Jakob B
Petersen, Svetlana I
Bangsgaard, Jens Peter
M Petersen, Peter
Vogelius, Ivan R
Aznar, Marianne C
Pokaż więcej
Temat :
Radiotherapy, Intensity-Modulated/methods
Models, Biological
Seminal Vesicles/pathology
Article
Radiotherapy Planning, Computer-Assisted/methods
Original Articles
Dose-Response Relationship, Radiation
Magnetic Resonance Imaging/methods
Radiotherapy Dosage
Journal Article
Organs at Risk/radiation effects
Humans
Male
Prostatic Neoplasms/pathology
Źródło :
Damkjaer, S, Thomsen, J B, Petersen, S I, Bangsgaard, J P, Petersen, P M, Vogelius, I R & Aznar, M C 2017, ' A modeling study of functional magnetic resonance imaging to individualize target definition of seminal vesicles for external beam radiotherapy ', Acta Oncologica, vol. 56, no. 6, pp. 799-805 . https://doi.org/10.1080/0284186X.2017.1300684
Damkjær, S, Thomsen, J B, Petersen, S I, Bangsgaard, J P, M Petersen, P, Vogelius, I R & Aznar, M C 2017, ' A modeling study of functional magnetic resonance imaging to individualize target definition of seminal vesicles for external beam radiotherapy ', Acta Oncologica, vol. 56, no. 6, pp. 799-805 . https://doi.org/10.1080/0284186X.2017.1300684
Acta Oncologica (Stockholm, Sweden)
Opis pliku :
application/pdf
Szczegóły Pełny tekst
Podgląd okładki
Tytuł :
TMPRSS2-ERG fusion promotes prostate cancer metastases in bone
Autorzy :
Deplus, Rachel
Delliaux, Carine
Marchand, Nathalie
Flourens, Anne
Vanpouille, Nathalie
Leroy, Xavier
de Launoit, Yvan
Duterque-Coquillaud, Martine
Pokaż więcej
Temat :
MESH: Animals
Sciences bio-médicales et agricoles
MESH: Male
Cell Movement -- physiology
Heterografts
Transfection
Mice
MESH: Prostatic Neoplasms/genetics
Mice, SCID
MESH: Bone Neoplasms/secondary
[SDV.CAN]Life Sciences [q-bio]/Cancer
MESH: Prostatic Neoplasms/pathology
MESH: Oncogene Proteins, Fusion/genetics
MESH: Neoplasm Metastasis
Neoplasm Metastasis
TMPRSS2-ERG
MESH: Prostatic Neoplasms/metabolism
Animals
MESH: Mice, SCID
Research Paper
MESH: Bone Neoplasms/genetics
MESH: Transfection
Prostatic Neoplasms -- genetics -- metabolism -- pathology
bone tropism
bone metastasis
MESH: Heterografts
urologic and male genital diseases
MESH: Oncogene Proteins, Fusion/biosynthesis
Oncogene Proteins, Fusion -- biosynthesis -- genetics
MESH: Humans
MESH: Bone Neoplasms/metabolism
Cell Line, Tumor
prostate cancer
MESH: Mice
Cell Proliferation -- physiology
[SDV]Life Sciences [q-bio]
Bone Neoplasms -- genetics -- metabolism -- secondary
MESH: Cell Proliferation/physiology
MESH: Cell Movement/physiology
Humans
Male
MESH: Cell Line, Tumor
Źródło :
Oncotarget, Impact journals, 2017, 8 (7), pp.11827-11840. ⟨10.18632/oncotarget.14399⟩
Oncotarget, Impact journals, 2017, 8 (7), ⟨10.18632/oncotarget.14399⟩
Opis pliku :
1 full-text file(s): application/pdf
Szczegóły
Podgląd okładki
Tytuł :
The ETS factor ESE3/EHF represses IL-6 preventing STAT3 activation and expansion of the prostate cancer stem-like compartment
Autorzy :
Albino, D.
Civenni, G.
Rossi, S.
Mitra, A.
Catapano, C.V.
Carbone, G.M.
Pokaż więcej
Temat :
ESE3/EHF
prostate cancer
Cell Line, Tumor
Cell Self Renewal/genetics
Cell Transformation, Neoplastic/genetics
Cell Transformation, Neoplastic/metabolism
Disease Progression
Epithelial-Mesenchymal Transition/genetics
Gene Expression Regulation, Neoplastic
Humans
Interleukin-6/genetics
Interleukin-6/metabolism
Janus Kinase 2/antagonists & inhibitors
Male
Models, Biological
Neoplastic Stem Cells/metabolism
Neoplastic Stem Cells/pathology
Phenotype
Promoter Regions, Genetic
Prostatic Neoplasms/genetics
Prostatic Neoplasms/metabolism
Prostatic Neoplasms/pathology
Protein Kinase Inhibitors/pharmacology
RNA Interference
RNA, Small Interfering/genetics
STAT3 Transcription Factor/metabolism
Transcription Factors/metabolism
Transcriptional Activation
ETS transcription factor
IL-6
cancer stem cells
Research Paper
Źródło :
Oncotarget, vol. 7, no. 47, pp. 76756-76768
Opis pliku :
application/pdf
Szczegóły
Podgląd okładki
Tytuł :
Inhibition of the GTPase Rac1 Mediates the Antimigratory Effects of Metformin in Prostate Cancer Cells
Autorzy :
Dirat, B.
Ader, I.
Golzio, M.
Massa, F.
Mettouchi, Amel
Laurent, K.
Larbret, F.
Malavaud, B.
Cormont, M.
Lemichez, Emmanuel
Cuvillier, O.
Tanti, J.
Bost, F.
Pokaż więcej
Temat :
MESH: Actin Cytoskeleton/drug effects
MESH: Actin Cytoskeleton/metabolism
MESH: Chemotaxis/drug effects
MESH: Cyclic AMP/metabolism
MESH: Humans
MESH: Guanine Nucleotide Exchange Factors/metabolism
MESH: Male
MESH: Metformin/pharmacology
MESH: Mice, Nude
MESH: Neoplasm Invasiveness
MESH: Neoplasm Metastasis
MESH: Prostatic Neoplasms/enzymology
MESH: Xenograft Model Antitumor Assays
MESH: Prostatic Neoplasms/pathology
MESH: rac1 GTP-Binding Protein/antagonists & inhibitors
MESH: Animals
MESH: rac1 GTP-Binding Protein/metabolism
MESH: Cell Line, Tumor
MESH: Cell Movement/drug effects
MESH: Cell Proliferation/drug effects
MESH: Chemokine CXCL12/pharmacology
[SDV]Life Sciences [q-bio]
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
[SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]
[SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]
Źródło :
Molecular Cancer Therapeutics
Molecular Cancer Therapeutics, American Association for Cancer Research, 2015, 14 (2), pp.586-596. ⟨10.1158/1535-7163.MCT-14-0102⟩
Szczegóły
Podgląd okładki
Tytuł :
TRP channel–associated factors are a novel protein family that regulates TRPM8 trafficking and activity
Autorzy :
Gkika, D.
Lemonnier, L.
Shapovalov, G.
Gordienko, D.
Poux, C.
Bernardini, M.
Bokhobza, A.
Bidaux, G.
Degerny, C.
Verreman, K.
Guarmit, B.
Benahmed, M.
Launoit, Y. de
Bindels, R.J.M.
Fiorio Pla, A.
Prevarskaya, N.
Pokaż więcej
Temat :
MESH: Protein Transport
MESH: Prostate/pathology
MESH: Kinetics
MESH: Male
MESH: Cell Movement
MESH: Ion Channel Gating
TRP channel-associated factor
HEK
MESH: Prostatic Neoplasms/pathology
Förster resonance energy transfer
MESH: Mice, Inbred C57BL
ML
MESH: Transfection
MESH: Prostatic Neoplasms/metabolism
MESH: HEK293 Cells
MESH: Adenocarcinoma/metabolism
MESH: Membrane Proteins/metabolism
MESH: Neoplasm Invasiveness
MESH: RNA Interference
Article
MESH: Protein Binding
TRP
LNCaP
MESH: Middle Aged
[SDV]Life Sciences [q-bio]
Research Articles
MESH: Signal Transduction
MESH: Cell Line, Tumor
MESH: TRPM Cation Channels/metabolism
MESH: Animals
MESH: Molecular Sequence Data
MESH: Adenocarcinoma/genetics
TCSPC
lymph node carcinoma of prostate
MESH: Membrane Proteins/genetics
FRET
quantitative real-time PCR
MESH: Amino Acid Sequence
MESH: Prostatic Neoplasms/genetics
Abbreviations used in this paper: EAPA2
MESH: Membrane Potentials
MESH: Adenocarcinoma/pathology
human embryonic kidney
TCAF
MESH: Prostate/metabolism
MESH: Humans
transient receptor potential
TD FLIM
[SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE]
maximum likelihood method
MESH: TRPM Cation Channels/genetics
qPCR
time-domain fluorescence lifetime imaging microscopy
Experimental Autoimmune Prostatitis Antigen 2
time-correlated single photon counting
Źródło :
Journal of Cell Biology, Rockefeller University Press, 2015, 208 (1), pp.89-107. ⟨10.1083/jcb.201402076⟩
Journal of Cell Biology, 208, 89 - 107
The Journal of Cell Biology
Opis pliku :
application/pdf
Szczegóły
Podgląd okładki
Tytuł :
Hypoxia dose painting in prostate and cervix cancer
Autorzy :
Hoskin, Peter J
Pokaż więcej
Temat :
Cell Hypoxia/radiation effects
Female
Humans
Male
Prostatic Neoplasms/pathology
Radiotherapy Planning, Computer-Assisted/methods
Radiotherapy, Intensity-Modulated/methods
Uterine Cervical Neoplasms/pathology
Źródło :
Hoskin, P J 2015, ' Hypoxia dose painting in prostate and cervix cancer ', Acta Oncologica, vol. 54, no. 9, pp. 1259-62 . https://doi.org/10.3109/0284186X.2015.1061692
Szczegóły Pełny tekst
Podgląd okładki
Tytuł :
Identification of novel TMPRSS2:ERG mechanisms in prostate cancer metastasis: involvement of MMP9 and PLXNA2
Autorzy :
Tian, T
Tomavo, N
Huot, L
Flourens, A
Bonnelye, E
Flajollet, S
Hot, D.
Leroy, X
de Launoit, Y
Duterque-Coquillaud, M.
Pokaż więcej
Temat :
MESH: Male
genetic structures
MESH: Nerve Tissue Proteins/metabolism
MESH: Gene Expression Regulation
MESH: Cell Movement
MESH: Lymphatic Metastasis
MESH: Receptors, Cell Surface/metabolism
MESH: Phenotype
TMPRSS2:ERG fusion
eye diseases
[SDV.CAN]Life Sciences [q-bio]/Cancer
MESH: Prostatic Neoplasms/pathology
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
MESH: Oncogene Proteins, Fusion/genetics
MMP9
MESH: Prostatic Neoplasms/metabolism
urologic and male genital diseases
sense organs
MESH: Humans
MESH: Matrix Metalloproteinase 9/metabolism
PLXNA2
MESH: Transcriptome
prostate cancer
MESH: Oncogene Proteins, Fusion/metabolism
MESH: Cell Proliferation
invasion
[SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology
migration
[SDV]Life Sciences [q-bio]
MESH: Cell Line, Tumor
Źródło :
Oncogene, Nature Publishing Group, 2014, 33 (17), pp.2204-2214. ⟨10.1038/onc.2013.176⟩
Szczegóły Pełny tekst
Podgląd okładki
Tytuł :
Forebyggelse af skeletrelaterede hændelser hos patienter med knoglemetastaser ved solide tumorer
Prevention of skeletal related events in patients with bone metastases from solid tumours
Autorzy :
Kamby, Claus
Tarp, Simon
Mellemgaard, Anders
Christensen, Robin
Cold, Søren
Eiken, Pia
Jakobsen, Erik Hugger
Langkilde, Niels Christian
Langkjer, Sven Tyge
Laursen, Torben
Ottesen, Svend Saalbach
Pedersen, Anita Gorm
Stenbygaard, Lars Eric
Vestlev, Peter Michael
Pokaż więcej
Temat :
Bone Density Conservation Agents/therapeutic use
Bone Neoplasms/complications
Breast Neoplasms/pathology
Denosumab/therapeutic use
Diphosphonates/therapeutic use
Female
Humans
Lung Neoplasms/pathology
Male
Meta-Analysis as Topic
Prostatic Neoplasms/pathology
Radiography
Źródło :
Kamby, C, Tarp, S, Mellemgaard, A, Christensen, R, Cold, S, Eiken, P, Jakobsen, E H, Langkilde, N C, Langkjer, S T, Laursen, T, Ottesen, S S, Pedersen, A G, Stenbygaard, L E & Vestlev, P M 2014, ' Forebyggelse af skeletrelaterede hændelser hos patienter med knoglemetastaser ved solide tumorer ', Ugeskrift for Laeger, bind 176, nr. 7, V08130525, s. 645-648 .
Szczegóły
Podgląd okładki
Tytuł :
Reply: Four-hundredfold overestimation of biopsy mortality
Autorzy :
Boniol, M.
Boyle, P.
Autier, P.
Ruffion, A.
Perrin, P.
Pokaż więcej
Temat :
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
[ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie
Biopsy/*mortality Humans Male Prostate/*pathology Prostate-Specific Antigen/*blood Prostatic Neoplasms/*pathology
Źródło :
BJU Int, 2013, 111 (3), pp.E17-8. ⟨10.1111/bju.12020_10⟩
BJU Int, 2013, 111 (3), pp.E17-8. 〈10.1111/bju.12020_10〉
Szczegóły Pełny tekst Pełny tekst
Podgląd okładki
Tytuł :
No Detection of XMRV in Blood Samples and Tissue Sections from Prostate Cancer Patients in Northern Europe.
Autorzy :
Stieler, Kristin
Schindler, Sarah
Schlomm, Thorsten
Hohn, Oliver
Bannert, Norbert
Simon, Ronald
Minner, Sarah
Schindler, Michael
Fischer, Nicole
Pokaż więcej
Temat :
Cell Line Tumor
Virus Replication
Xenotropic murine leukemia virus-related virus/isolation & purification
Lymphocyte Activation/immunology
610 Medizin
Immunohistochemistry
ddc:610
Europe
Polymerase Chain Reaction
Prostatic Neoplasms/pathology
Case-Control Studies
Xenotropic murine leukemia virus-related virus/genetics
Leukocytes Mononuclear/virology
Prostate/virology
urologic and male genital diseases
Prostatic Neoplasms/blood
Aged
Prostatic Neoplasms/virology
Prostate/pathology
Middle Aged
Viral Proteins/metabolism
Retroviridae Infections/virology
Xenotropic murine leukemia virus-related virus/physiology
Coculture Techniques
Cell Separation
virus diseases
Adult
Humans
Male
Opis pliku :
application/pdf
Szczegóły Pełny tekst
Wyświetlanie 1-20 z 86

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