Temat: "Proteasome Endopeptidase Complex" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Metabolic regulation of the proteasome under hypoxia by Poldip2 controls fibrotic signaling in vascular smooth muscle cells.
Autorzy:: Paredes F; Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA, 30322, USA.
Williams HC; Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA, 30322, USA.
Suster I; Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA, 30322, USA.
Tejos M; Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA, 30322, USA.
Fuentealba R; Institute of Chemistry and Natural Resources, Universidad de Talca, Talca, 3460000, Chile.
Bogan B; Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA, 30322, USA.
Holden CM; Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA, 30322, USA.
San Martin A; Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA, 30322, USA. Electronic address: .; Pokaż więcej
Źródło:: Free radical biology & medicine [Free Radic Biol Med] 2023 Feb 01; Vol. 195, pp. 283-297. Date of Electronic Publication: 2022 Dec 31.
Typ publikacji:: Journal Article
MeSH Terms:: Proteasome Endopeptidase Complex*/genetics
Proteasome Endopeptidase Complex*/metabolism
Nuclear Proteins*/metabolism
Humans ; Muscle, Smooth, Vascular/metabolism ; Signal Transduction ; Hypoxia/genetics ; Hypoxia/metabolism ; Connective Tissue Growth Factor/genetics ; Connective Tissue Growth Factor/metabolism

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Skocz do pozycji: 2.

Tytuł:: Deubiquitylase PSMD14 inhibits autophagy to promote ovarian cancer progression via stabilization of LRPPRC.
Autorzy:: Zhao Z; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xu H; Departments of Gynecological Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital l & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
Wei Y; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, Shanxi, China.
Sun L; Departments of Gynecological Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital l & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China; Departments of Gynecological Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: .
Song Y; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: .; Pokaż więcej
Źródło:: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2023 Feb; Vol. 1869 (2), pp. 166594. Date of Electronic Publication: 2022 Nov 01.
Typ publikacji:: Journal Article
MeSH Terms:: Autophagy*/genetics
Neoplasm Proteins*/metabolism
Ovarian Neoplasms*/pathology
Proteasome Endopeptidase Complex*/genetics
Proteasome Endopeptidase Complex*/metabolism
Trans-Activators*/genetics
Trans-Activators*/metabolism
Female ; Humans ; Cell Line, Tumor ; Proteolysis ; Ubiquitination ; Protein Stability

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Skocz do pozycji: 3.

Tytuł:: Inhibition of 26S proteasome enhances AKAP3-mediated cAMP-PKA signaling during boar sperm capacitation.
Autorzy:: Qu X; Department of Animal Science, College of Agriculture, Yanbian University, Yanji 133000, China.
Han Y; Department of Animal Science, College of Agriculture, Yanbian University, Yanji 133000, China.
Chen X; Department of Animal Science, College of Agriculture, Yanbian University, Yanji 133000, China.
Lv Y; Department of Animal Science, College of Agriculture, Yanbian University, Yanji 133000, China.
Zhang Y; Department of Animal Science, College of Agriculture, Yanbian University, Yanji 133000, China.
Cao L; Department of Animal Science, College of Agriculture, Yanbian University, Yanji 133000, China.
Zhang J; Department of Animal Science, College of Agriculture, Yanbian University, Yanji 133000, China.
Jin Y; Department of Animal Science, College of Agriculture, Yanbian University, Yanji 133000, China. Electronic address: .; Pokaż więcej
Źródło:: Animal reproduction science [Anim Reprod Sci] 2022 Dec; Vol. 247, pp. 107079. Date of Electronic Publication: 2022 Sep 24.
Typ publikacji:: Journal Article
MeSH Terms:: Sperm Capacitation*
Proteasome Endopeptidase Complex*/metabolism
Proteasome Endopeptidase Complex*/pharmacology
Male ; Swine ; Animals ; Semen/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Spermatozoa ; Phosphorylation ; Tyrosine/metabolism ; Serine/metabolism ; Serine/pharmacology ; Threonine/metabolism ; Threonine/pharmacology ; Ubiquitins/metabolism

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Skocz do pozycji: 4.

Tytuł:: Inhibition of proteasome, but not lysosome, upregulates organic anion transporter 3 in vitro and in vivo.
Autorzy:: Fan Y; Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Wang H; Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Yu Z; Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Liang Z; Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Li Y; Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
You G; Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA. Electronic address: .; Pokaż więcej
Źródło:: Biochemical pharmacology [Biochem Pharmacol] 2023 Feb; Vol. 208, pp. 115387. Date of Electronic Publication: 2022 Dec 19.
Typ publikacji:: Journal Article
MeSH Terms:: Proteasome Endopeptidase Complex*/metabolism
Antineoplastic Agents*
Rats ; Animals ; Bortezomib/pharmacology ; Organic Anion Transporters, Sodium-Independent/metabolism ; Rats, Sprague-Dawley ; Organic Anion Transport Protein 1

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Skocz do pozycji: 5.

Tytuł:: SUMOylation-mediated PSME3-20 S proteasomal degradation of transcription factor CP2c is crucial for cell cycle progression.
Autorzy:: Son SH; Department of Life Science and Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.
Kim MY; Department of Life Science and Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.
Lim YS; Department of Life Science and Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.
Jin HC; Department of Life Science and Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.
Shin JH; Department of Life Science and Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.
Yi JK; Department of Life Science and Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.
Choi S; Department of Life Science and Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.
Park MA; Department of Life Science and Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.
Chae JH; Department of Life Science and Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.
Kang HC; Department of Life Science and Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.
Lee YJ; Department of Life Science and Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.
Uversky VN; Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Kim CG; Department of Life Science and Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.; CGK Biopharma Co. Ltd., Seoul 04763, Korea.; Pokaż więcej
Źródło:: Science advances [Sci Adv] 2023 Jan 27; Vol. 9 (4), pp. eadd4969. Date of Electronic Publication: 2023 Jan 27.
Typ publikacji:: Journal Article
MeSH Terms:: Proteasome Endopeptidase Complex*/metabolism
Neoplasms*/metabolism
Humans ; Transcription Factors/metabolism ; Sumoylation ; Cytoplasm/metabolism ; Cell Cycle ; DNA-Binding Proteins/metabolism

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Skocz do pozycji: 6.

Tytuł:: Inducible Degradation of Oncogenic Nucleolin Using an Aptamer-Based PROTAC.
Autorzy:: Chen M; School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, China.
Zhou P; Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan 250014, China.
Kong Y; Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan 250014, China.
Li J; School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, China.
Li Y; Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan 250014, China.
Zhang Y; Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan 250014, China.
Ran J; Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan 250014, China.
Zhou J; Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan 250014, China.; College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China.
Chen Y; Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan 250014, China.
Xie S; School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, China.; Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan 250014, China.; Pokaż więcej
Źródło:: Journal of medicinal chemistry [J Med Chem] 2023 Jan 26; Vol. 66 (2), pp. 1339-1348. Date of Electronic Publication: 2023 Jan 06.
Typ publikacji:: Journal Article
MeSH Terms:: Proteasome Endopeptidase Complex*/metabolism
Phosphoproteins*/metabolism
Proteolysis ; RNA-Binding Proteins/metabolism ; Ubiquitin-Protein Ligases/metabolism

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Szczegóły

Skocz do pozycji: 7.

Tytuł:: Discovery of Highly Selective Inhibitors of the Human Constitutive Proteasome β5c Chymotryptic Subunit.
Autorzy:: Zhan W; Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave., New York, New York 10065, United States.
Li D; Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave., New York, New York 10065, United States.
Saha P; Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave., New York, New York 10065, United States.
Wang R; NMR Analytical Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Zhang H; Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave., New York, New York 10065, United States.
Ajay AK; Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Deban C; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Sukenick G; NMR Analytical Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Azzi J; Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Lin G; Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave., New York, New York 10065, United States.; Pokaż więcej
Źródło:: Journal of medicinal chemistry [J Med Chem] 2023 Jan 26; Vol. 66 (2), pp. 1172-1185. Date of Electronic Publication: 2023 Jan 06.
Typ publikacji:: Journal Article
MeSH Terms:: Proteasome Endopeptidase Complex*/metabolism
Asparagine*
Humans ; Kinetics ; Structure-Activity Relationship ; Proteasome Inhibitors/pharmacology ; Proteasome Inhibitors/chemistry

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Skocz do pozycji: 8.

Tytuł:: Small-molecule inhibitors of proteasome increase CjCas9 protein stability.
Autorzy:: Yaméogo P; Centre de Recherche du CHU de Québec-Université Laval, Québec City, QC, Canada.; Département de Médecine Moléculaire, Université Laval, Québec City, QC, Canada.
Majeau N; Centre de Recherche du CHU de Québec-Université Laval, Québec City, QC, Canada.; Département de Médecine Moléculaire, Université Laval, Québec City, QC, Canada.
Mbakam CH; Centre de Recherche du CHU de Québec-Université Laval, Québec City, QC, Canada.; Département de Médecine Moléculaire, Université Laval, Québec City, QC, Canada.
Tremblay JP; Centre de Recherche du CHU de Québec-Université Laval, Québec City, QC, Canada.; Département de Médecine Moléculaire, Université Laval, Québec City, QC, Canada.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Jan 19; Vol. 18 (1), pp. e0280353. Date of Electronic Publication: 2023 Jan 19 (Print Publication: 2023).
Typ publikacji:: Journal Article
MeSH Terms:: Proteasome Endopeptidase Complex*/genetics
Cytomegalovirus Infections*/genetics
Humans ; Bortezomib/pharmacology ; HeLa Cells ; HEK293 Cells ; Gene Editing ; CRISPR-Cas Systems ; Proteasome Inhibitors/pharmacology ; Protein Stability

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Skocz do pozycji: 9.

Tytuł:: Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10.
Autorzy:: Ivaldo C; Department of Experimental Medicine, University of Genoa, Via L.B.Alberti 2, I-16132, Genova, Italy.; Litwin-Zucker Alzheimer's Research Center, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.
Passalacqua M; Department of Experimental Medicine, University of Genoa, Via L.B.Alberti 2, I-16132, Genova, Italy.
Furfaro AL; Department of Experimental Medicine, University of Genoa, Via L.B.Alberti 2, I-16132, Genova, Italy.
d'Abramo C; Litwin-Zucker Alzheimer's Research Center, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.; Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.
Ruiz S; Litwin-Zucker Alzheimer's Research Center, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.
Chatterjee PK; Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.
Metz CN; Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
Nitti M; Department of Experimental Medicine, University of Genoa, Via L.B.Alberti 2, I-16132, Genova, Italy. .
Marambaud P; Litwin-Zucker Alzheimer's Research Center, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.; Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Jan 11; Vol. 13 (1), pp. 597. Date of Electronic Publication: 2023 Jan 11.
Typ publikacji:: Journal Article
MeSH Terms:: Amyloid Precursor Protein Secretases*/metabolism
Proteasome Endopeptidase Complex*/metabolism
Humans ; Endothelial Cells/metabolism ; Hydrogen Peroxide/pharmacology ; Hydrogen Peroxide/metabolism ; Cadherins/metabolism ; Oxidative Stress ; Matrix Metalloproteinases/metabolism ; Cells, Cultured ; Adherens Junctions/metabolism ; Bone Morphogenetic Proteins/metabolism

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Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 10.

Tytuł:: InvitroSPI and a large database of proteasome-generated spliced and non-spliced peptides.
Autorzy:: Roetschke HP; Max-Planck-Institute for Multidisciplinary Sciences (MPI-NAT), 37077, Göttingen, Germany.; Centre for Inflammation Biology and Cancer Immunology (CIBCI) & Peter Gorer Department of Immunobiology, King's College London (KCL), SE1 1UL, London, UK.
Rodriguez-Hernandez G; Centre for Inflammation Biology and Cancer Immunology (CIBCI) & Peter Gorer Department of Immunobiology, King's College London (KCL), SE1 1UL, London, UK.; Francis Crick Institute, NW1 1AT, London, UK.
Cormican JA; Max-Planck-Institute for Multidisciplinary Sciences (MPI-NAT), 37077, Göttingen, Germany.
Yang X; Proteomics Core Facility, James Black Centre, King's College London (KCL), SE5 9NU, London, UK.
Lynham S; Proteomics Core Facility, James Black Centre, King's College London (KCL), SE5 9NU, London, UK.
Mishto M; Centre for Inflammation Biology and Cancer Immunology (CIBCI) & Peter Gorer Department of Immunobiology, King's College London (KCL), SE1 1UL, London, UK. .; Francis Crick Institute, NW1 1AT, London, UK. .
Liepe J; Max-Planck-Institute for Multidisciplinary Sciences (MPI-NAT), 37077, Göttingen, Germany. .; Pokaż więcej
Źródło:: Scientific data [Sci Data] 2023 Jan 10; Vol. 10 (1), pp. 18. Date of Electronic Publication: 2023 Jan 10.
Typ publikacji:: Dataset; Journal Article
MeSH Terms:: CD8-Positive T-Lymphocytes*
Proteasome Endopeptidase Complex*
Humans ; Cytoplasm ; Histocompatibility Antigens Class I ; Peptides/chemistry

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Szczegóły

Skocz do pozycji: 11.

Tytuł:: Reciprocal REG γ -Nrf2 Regulation Promotes Long Period ROS Scavenging in Oxidative Stress-Induced Cell Aging.
Autorzy:: Kibreab S; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China.
Wang Z; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China.
Zhu X; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China.
Ren Y; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China.
Jing Y; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China.
Li X; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China.
Li L; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China.
Zhang B; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China.; Pokaż więcej
Źródło:: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2023 Jan 10; Vol. 2023, pp. 4743885. Date of Electronic Publication: 2023 Jan 10 (Print Publication: 2023).
Typ publikacji:: Journal Article
MeSH Terms:: NF-E2-Related Factor 2*/metabolism
Proteasome Endopeptidase Complex*/metabolism
Antioxidants/pharmacology ; Cellular Senescence ; Glycogen Synthase Kinase 3 beta/metabolism ; Hydrogen Peroxide/pharmacology ; Hydrogen Peroxide/metabolism ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Animals

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Skocz do pozycji: 12.

Tytuł:: Emerging TACnology: Heterobifunctional Small Molecule Inducers of Targeted Posttranslational Protein Modifications.
Autorzy:: Heitel P; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Jan 10; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 10.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Proteasome Endopeptidase Complex*/metabolism
Drug Discovery*
Proteolysis ; Ubiquitination ; Signal Transduction ; Cytochrome P-450 Enzyme Inducers

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Skocz do pozycji: 13.

Tytuł:: Aptamer Inhibits Tumor Growth by Leveraging Cellular Proteasomal Degradation System to Degrade c-Met in Mice.
Autorzy:: Chen K; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, China.
Cai J; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, China.
Wang S; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, China.
Li Y; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, China.
Yang C; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, China.
Fu T; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, China.
Zhao Z; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, China.
Zhang X; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, China.
Tan W; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, China.; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China.; Institute of Molecular Medicine (IMM), Renji Hospital, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.; Pokaż więcej
Źródło:: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2023 Jan 09; Vol. 62 (2), pp. e202208451. Date of Electronic Publication: 2022 Dec 07.
Typ publikacji:: Journal Article
MeSH Terms:: Proteasome Endopeptidase Complex*/metabolism
Ubiquitin-Protein Ligases*/metabolism
Mice ; Animals ; Cytoplasm/metabolism ; Ubiquitination ; Phosphorylation

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Skocz do pozycji: 14.

Tytuł:: PROTAC-DB 2.0: an updated database of PROTACs.
Autorzy:: Weng G; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.; CarbonSilicon AI Technology Co., Ltd, Hangzhou 310018, Zhejiang, China.
Cai X; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.
Cao D; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410004, Hunan, China.
Du H; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.
Shen C; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.
Deng Y; CarbonSilicon AI Technology Co., Ltd, Hangzhou 310018, Zhejiang, China.
He Q; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.
Yang B; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.
Li D; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.
Hou T; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.; Pokaż więcej
Źródło:: Nucleic acids research [Nucleic Acids Res] 2023 Jan 06; Vol. 51 (D1), pp. D1367-D1372.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Proteasome Endopeptidase Complex*/metabolism
Proteolysis*
Databases, Protein*
Proteins/metabolism ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/metabolism

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Skocz do pozycji: 15.

Tytuł:: Novel Oxygen-Dependent Degradable Immunotoxin Regulated by the Ubiquitin-Proteasome System Reduces Nonspecific Cytotoxicity.
Autorzy:: Wei M; State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Chen A; State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Zhang J; State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Ren Y; State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.; Pokaż więcej
Źródło:: Molecular pharmaceutics [Mol Pharm] 2023 Jan 02; Vol. 20 (1), pp. 90-100. Date of Electronic Publication: 2022 Oct 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Immunotoxins*/pharmacology
Proteasome Endopeptidase Complex*
Humans ; Hypoxia ; Hypoxia-Inducible Factor 1, alpha Subunit ; Oxygen/metabolism ; Ubiquitin

Czasopismo naukowe

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Szczegóły

Skocz do pozycji: 16.

Tytuł:: Novel insights into the non-canonical roles of PSMD14/POH1/Rpn11 in proteostasis and in the modulation of cancer progression.
Autorzy:: Bustamante HA; Instituto de Microbiología Clínica, Facultad de Medicina, Universidad Austral de Chile, Valdivia 5110566, Chile. Electronic address: .
Albornoz N; Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago 7510157, Chile; Centro Ciencia & Vida, Fundación Ciencia & Vida, Santiago 7780272, Chile. Electronic address: .
Morselli E; Departamento de Ciencias Básicas, Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago 7510157, Chile; Centro de Investigación en Autofagia, Santiago, Chile. Electronic address: .
Soza A; Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago 7510157, Chile; Centro de Envejecimiento y Regeneración (CARE-UC), Facultad de Ciencias Biológicas, Pontificia Universidad Católica, Santiago 8331150, Chile; Centro Ciencia & Vida, Fundación Ciencia & Vida, Santiago 7780272, Chile. Electronic address: .
Burgos PV; Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago 7510157, Chile; Centro de Investigación en Autofagia, Santiago, Chile; Centro de Envejecimiento y Regeneración (CARE-UC), Facultad de Ciencias Biológicas, Pontificia Universidad Católica, Santiago 8331150, Chile; Centro Ciencia & Vida, Fundación Ciencia & Vida, Santiago 7780272, Chile. Electronic address: .; Pokaż więcej
Źródło:: Cellular signalling [Cell Signal] 2023 Jan; Vol. 101, pp. 110490. Date of Electronic Publication: 2022 Oct 12.
Typ publikacji:: Journal Article
MeSH Terms:: Proteasome Endopeptidase Complex*/metabolism
Neoplasms*
Humans ; Proteostasis ; Ubiquitin/metabolism ; Trans-Activators/metabolism

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Szczegóły

Skocz do pozycji: 17.

Tytuł:: ELIOT: A platform to navigate the E3 pocketome and aid the design of new PROTACs.
Autorzy:: Palomba T; Laboratory for Chemometrics and Molecular Modeling, Department of Chemistry, Biology, and Biotechnology, University of Perugia, Perugia, Italy.
Baroni M; Molecular Discovery Ltd., The Kinetic Centre, Hertfordshire, UK.
Cross S; Molecular Discovery Ltd., The Kinetic Centre, Hertfordshire, UK.
Cruciani G; Laboratory for Chemometrics and Molecular Modeling, Department of Chemistry, Biology, and Biotechnology, University of Perugia, Perugia, Italy.
Siragusa L; Molecular Discovery Ltd., The Kinetic Centre, Hertfordshire, UK.; Molecular Horizon Srl, Bettona, Italy.; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2023 Jan; Vol. 101 (1), pp. 69-86. Date of Electronic Publication: 2022 Jul 27.
Typ publikacji:: Journal Article
MeSH Terms:: Ubiquitin-Protein Ligases*/metabolism
Proteasome Endopeptidase Complex*
Humans ; Proteolysis ; Ligands ; Proteins/metabolism

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Szczegóły

Skocz do pozycji: 18.

Tytuł:: Inactive Proteasomes Routed to Autophagic Turnover Are Confined within the Soluble Fraction of the Cell.
Autorzy:: Friedman K; Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Karmon O; Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.; NUS-HUJ-CREATE Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 138602, Singapore.
Fridman U; Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Goldberg Y; Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Pines O; NUS-HUJ-CREATE Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 138602, Singapore.; Department of Microbiology and Molecular Genetics, The Institute for Medical Research Israel-Canada (IMRIC), Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Ben-Aroya S; Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2022 Dec 30; Vol. 13 (1). Date of Electronic Publication: 2022 Dec 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Proteasome Endopeptidase Complex*/metabolism
Autophagy*/physiology
Cytoplasm/metabolism ; Saccharomyces cerevisiae/metabolism ; Ubiquitination

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Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 19.

Tytuł:: Sodium fluoride induces skeletal muscle atrophy via changes in mitochondrial and sarcomeric proteomes.
Autorzy:: Nagendra AH; Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya Deemed to be University, Deralakatte, Mangalore, India.
Ray A; Father Muller Research Centre, Father Muller Medical College, Father Muller Charitable Institutions, Kankanady, Mangalore, Karnataka, India.
Chaudhury D; Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya Deemed to be University, Deralakatte, Mangalore, India.
Mitra A; Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya Deemed to be University, Deralakatte, Mangalore, India.
Ranade AV; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Bose B; Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya Deemed to be University, Deralakatte, Mangalore, India.
Shenoy P S; Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya Deemed to be University, Deralakatte, Mangalore, India.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2022 Dec 22; Vol. 17 (12), pp. e0279261. Date of Electronic Publication: 2022 Dec 22 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Proteasome Endopeptidase Complex*/metabolism
Proteome*/metabolism
Mice ; Animals ; Sodium Fluoride/pharmacology ; Muscular Atrophy/pathology ; Muscle, Skeletal/metabolism ; Ubiquitin/metabolism ; Mitochondrial Proteins/metabolism

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Skocz do pozycji: 20.

Tytuł:: Study on ZmRPN10 Regulating Leaf Angle in Maize by RNA-Seq.
Autorzy:: Ji X; College of Agronomy, Gansu Agricultural University, Lanzhou 730070, China.; Gansu Provincial Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou 730070, China.; Gansu Key Laboratory of Crop Improvement & Germplasm Enhancement, Lanzhou 730070, China.
Jin B; College of Agronomy, Gansu Agricultural University, Lanzhou 730070, China.; Gansu Provincial Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou 730070, China.; Gansu Key Laboratory of Crop Improvement & Germplasm Enhancement, Lanzhou 730070, China.
Zhuang Z; College of Agronomy, Gansu Agricultural University, Lanzhou 730070, China.; Gansu Provincial Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou 730070, China.; Gansu Key Laboratory of Crop Improvement & Germplasm Enhancement, Lanzhou 730070, China.
Chang F; College of Agronomy, Gansu Agricultural University, Lanzhou 730070, China.; Gansu Provincial Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou 730070, China.; Gansu Key Laboratory of Crop Improvement & Germplasm Enhancement, Lanzhou 730070, China.
Wang F; College of Agronomy, Gansu Agricultural University, Lanzhou 730070, China.; Gansu Provincial Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou 730070, China.; Gansu Key Laboratory of Crop Improvement & Germplasm Enhancement, Lanzhou 730070, China.
Peng Y; College of Agronomy, Gansu Agricultural University, Lanzhou 730070, China.; Gansu Provincial Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou 730070, China.; Gansu Key Laboratory of Crop Improvement & Germplasm Enhancement, Lanzhou 730070, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 22; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 22.
Typ publikacji:: Journal Article
MeSH Terms:: Zea mays*
Proteasome Endopeptidase Complex*/metabolism
RNA-Seq ; Plant Breeding ; Plant Leaves/metabolism ; Ubiquitin/metabolism ; Gene Expression Regulation, Plant ; Plant Proteins/genetics ; Plant Proteins/metabolism

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