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Wyszukujesz frazę ""Proteasome Endopeptidase Complex"" wg kryterium: Temat


Tytuł :
PINK1-induced phosphorylation of mitofusin 2 at serine 442 causes its proteasomal degradation and promotes cell proliferation in lung cancer and pulmonary arterial hypertension.
Autorzy :
Dasgupta A; Department of Medicine, Queen's University, Kingston, ON, Canada.
Chen KH; Department of Medicine, Queen's University, Kingston, ON, Canada.
Lima PDA; Queen's Cardiopulmonary Unit (QCPU), Department of Medicine, Translational Institute of Medicine (TIME), Queen's University, Kingston, ON, Canada.
Mewburn J; Department of Medicine, Queen's University, Kingston, ON, Canada.
Wu D; Department of Medicine, Queen's University, Kingston, ON, Canada.
Al-Qazazi R; Department of Medicine, Queen's University, Kingston, ON, Canada.
Jones O; Queen's Cardiopulmonary Unit (QCPU), Department of Medicine, Translational Institute of Medicine (TIME), Queen's University, Kingston, ON, Canada.
Tian L; Department of Medicine, Queen's University, Kingston, ON, Canada.; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Potus F; Department of Medicine, Queen's University, Kingston, ON, Canada.; Pulmonary Hypertension Research Group, Institut Universitaire de Cardiologie et de Pneumologie de Québec Research Center, Laval University, Quebec City, QC, Canada.
Bonnet S; Pulmonary Hypertension Research Group, Institut Universitaire de Cardiologie et de Pneumologie de Québec Research Center, Laval University, Quebec City, QC, Canada.
Archer SL; Department of Medicine, Queen's University, Kingston, ON, Canada.; Queen's Cardiopulmonary Unit (QCPU), Department of Medicine, Translational Institute of Medicine (TIME), Queen's University, Kingston, ON, Canada.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Aug; Vol. 35 (8), pp. e21771.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*
Proteolysis*
GTP Phosphohydrolases/*metabolism
Hypertension, Pulmonary/*metabolism
Lung Neoplasms/*metabolism
Mitochondrial Proteins/*metabolism
Neoplasm Proteins/*metabolism
Proteasome Endopeptidase Complex/*metabolism
Protein Kinases/*metabolism
A549 Cells ; Animals ; GTP Phosphohydrolases/genetics ; Humans ; Hypertension, Pulmonary/genetics ; Lung Neoplasms/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Mitochondrial Proteins/genetics ; Neoplasm Proteins/genetics ; Phosphorylation/genetics ; Proteasome Endopeptidase Complex/genetics ; Protein Kinases/genetics
Czasopismo naukowe
Tytuł :
Circular circPSMC3 inhibits hepatocellular carcinoma migration and invasion by upregulating RBM5.
Autorzy :
Tang B; Department of General Surgery, Ezhou Central Hospital, Ezhou, China.
Wang Y; Department of Infectious Disease, Ezhou Central Hospital, Ezhou, China.
Zhu F; Department of General Surgery, Ezhou Central Hospital, Ezhou, China.
Li H; Department of Pediatric Urosurgery, Ezhou Central Hospital, Ezhou, China.
Liu L; Department of General Surgery, Ezhou Central Hospital, Ezhou, China.
Chen Y; Department of General Surgery, Ezhou Central Hospital, Ezhou, China.
Zhou Y; Department of General Surgery, Ezhou Central Hospital, Ezhou, China - .
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Źródło :
Minerva medica [Minerva Med] 2021 Aug; Vol. 112 (4), pp. 521-522. Date of Electronic Publication: 2019 Nov 11.
Typ publikacji :
Letter
MeSH Terms :
ATPases Associated with Diverse Cellular Activities/*metabolism
Carcinoma, Hepatocellular/*metabolism
Cell Cycle Proteins/*metabolism
DNA-Binding Proteins/*metabolism
Liver Neoplasms/*metabolism
Proteasome Endopeptidase Complex/*metabolism
RNA, Circular/*metabolism
RNA-Binding Proteins/*metabolism
Tumor Suppressor Proteins/*metabolism
ATPases Associated with Diverse Cellular Activities/genetics ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Cell Movement ; DNA-Binding Proteins/genetics ; Humans ; Kaplan-Meier Estimate ; Liver/metabolism ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; Neoplasm Invasiveness ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Proteasome Endopeptidase Complex/genetics ; RNA-Binding Proteins/genetics ; Tumor Suppressor Proteins/genetics
Opinia redakcyjna
Tytuł :
P62 Links the Autophagy Pathway and the Ubiquitin-Proteasome System in Endothelial Cells during Atherosclerosis.
Autorzy :
Kim S; College of Korean Medicine, Sangji University, Wonju 26339, Korea.; Department of Cognitive Science, Yonsei University, Seoul 03722, Korea.
Lee W; Department of Cognitive Science, Yonsei University, Seoul 03722, Korea.; Department of Neurology, College of Medicine, Yonsei University, Seoul 03722, Korea.
Cho K; Department of Life Science, Kyonggi University, Suwon 16227, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 21; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*
Proteolysis*
Ubiquitination*
Atherosclerosis/*pathology
Endothelial Cells/*pathology
Proteasome Endopeptidase Complex/*metabolism
Sequestosome-1 Protein/*metabolism
Atherosclerosis/metabolism ; Endothelial Cells/metabolism ; Humans ; Proteasome Endopeptidase Complex/genetics ; Sequestosome-1 Protein/genetics ; Signal Transduction ; Ubiquitin/metabolism
Czasopismo naukowe
Tytuł :
A Proteasome Mutation Sensitizes P. falciparum Cam3.II K13 Parasites to DHA and OZ439.
Autorzy :
Rosenthal MR; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Ng CL; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
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Źródło :
ACS infectious diseases [ACS Infect Dis] 2021 Jul 09; Vol. 7 (7), pp. 1923-1931. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antimalarials*/pharmacology
Plasmodium falciparum*/drug effects
Plasmodium falciparum*/enzymology
Plasmodium falciparum*/genetics
Proteasome Endopeptidase Complex*/genetics
Drug Resistance ; Mutation ; Protozoan Proteins/genetics
Czasopismo naukowe
Tytuł :
Discovery of selective fragment-sized immunoproteasome inhibitors.
Autorzy :
Kollár L; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Magyar tudósok krt. 2, H-1117, Budapest, Hungary.
Gobec M; University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, SI-1000, Ljubljana, Slovenia.
Szilágyi B; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Magyar tudósok krt. 2, H-1117, Budapest, Hungary.
Proj M; University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, SI-1000, Ljubljana, Slovenia.
Knez D; University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, SI-1000, Ljubljana, Slovenia.
Ábrányi-Balogh P; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Magyar tudósok krt. 2, H-1117, Budapest, Hungary.
Petri L; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Magyar tudósok krt. 2, H-1117, Budapest, Hungary.
Imre T; MS Metabolomics Research Group, Research Centre for Natural Sciences, Magyar tudósok krt. 2, H-1117, Budapest, Hungary.
Bajusz D; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Magyar tudósok krt. 2, H-1117, Budapest, Hungary.
Ferenczy GG; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Magyar tudósok krt. 2, H-1117, Budapest, Hungary.
Gobec S; University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, SI-1000, Ljubljana, Slovenia.
Keserű GM; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Magyar tudósok krt. 2, H-1117, Budapest, Hungary. Electronic address: .
Sosič I; University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, SI-1000, Ljubljana, Slovenia. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Jul 05; Vol. 219, pp. 113455. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Proteasome Endopeptidase Complex/*metabolism
Proteasome Inhibitors/*chemistry
Drug Evaluation, Preclinical ; Humans ; Inhibitory Concentration 50 ; Oxazoles/chemistry ; Proteasome Endopeptidase Complex/chemistry ; Proteasome Inhibitors/metabolism ; Protein Subunits/antagonists & inhibitors ; Protein Subunits/metabolism ; Structure-Activity Relationship ; Thiazoles/chemistry ; Thiones/chemistry
Czasopismo naukowe
Tytuł :
Immunoproteasome and Non-Covalent Inhibition: Exploration by Advanced Molecular Dynamics and Docking Methods.
Autorzy :
Culletta G; Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy.; Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università di Messina, Viale Annunziata, 98168 Messina, Italy.
Zappalà M; Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università di Messina, Viale Annunziata, 98168 Messina, Italy.
Ettari R; Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università di Messina, Viale Annunziata, 98168 Messina, Italy.
Almerico AM; Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy.
Tutone M; Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jul 02; Vol. 26 (13). Date of Electronic Publication: 2021 Jul 02.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Docking Simulation*
Proteasome Endopeptidase Complex/*chemistry
Proteasome Inhibitors/*pharmacology
Binding Sites ; Dipeptides/chemistry ; Dipeptides/pharmacology ; Molecular Dynamics Simulation ; Oligopeptides/chemistry ; Oligopeptides/pharmacology ; Organosilicon Compounds/chemistry ; Organosilicon Compounds/pharmacology ; Proteasome Endopeptidase Complex/metabolism ; Proteasome Inhibitors/chemistry ; Protein Binding
Czasopismo naukowe
Tytuł :
Ubiquitination of Histone H2B by Proteasome Subunit RPT6 Controls Histone Methylation Chromatin Dynamics During Memory Formation.
Autorzy :
Jarome TJ; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama; Fralin Biomedical Research Institute, Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, Virginia; School of Neuroscience, Virginia Polytechnic Institute and State University, Roanoke, Virginia; Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Roanoke, Virginia.
Perez GA; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama.
Webb WM; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama.
Hatch KM; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama.
Navabpour S; Fralin Biomedical Research Institute, Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, Virginia.
Musaus M; School of Neuroscience, Virginia Polytechnic Institute and State University, Roanoke, Virginia.
Farrell K; Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Roanoke, Virginia.
Hauser RM; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama.
McFadden T; Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Roanoke, Virginia.
Martin K; School of Neuroscience, Virginia Polytechnic Institute and State University, Roanoke, Virginia.
Butler AA; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama.
Wang J; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama.
Lubin FD; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address: .
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Źródło :
Biological psychiatry [Biol Psychiatry] 2021 Jun 15; Vol. 89 (12), pp. 1176-1187. Date of Electronic Publication: 2021 Jan 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Histones*/metabolism
Proteasome Endopeptidase Complex*/genetics
Proteasome Endopeptidase Complex*/metabolism
Animals ; Chromatin ; Methylation ; Rats ; Ubiquitination
Czasopismo naukowe
Tytuł :
Proteasome subunit beta type-8 from sevenband grouper negatively regulates cytokine responses by interfering NF-κB signaling upon nervous necrosis viral infection.
Autorzy :
Krishnan R; Department of Aqualife Medicine, Chonnam National University, Yeosu, Republic of Korea.
Kim JO; Institute of Marine Biotechnology, Pukyong National University, Busan, Republic of Korea. Electronic address: .
Jang YS; Department of Aqualife Medicine, Chonnam National University, Yeosu, Republic of Korea.
Oh MJ; Department of Aqualife Medicine, Chonnam National University, Yeosu, Republic of Korea. Electronic address: .
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Źródło :
Fish & shellfish immunology [Fish Shellfish Immunol] 2021 Jun; Vol. 113, pp. 118-124. Date of Electronic Publication: 2021 Apr 13.
Typ publikacji :
Journal Article
MeSH Terms :
Bass/*genetics
Bass/*immunology
Fish Diseases/*immunology
Gene Expression Regulation/*immunology
Immunity/*genetics
Proteasome Endopeptidase Complex/*genetics
Proteasome Endopeptidase Complex/*immunology
Amino Acid Sequence ; Animals ; Fish Diseases/virology ; Fish Proteins/chemistry ; Fish Proteins/genetics ; Fish Proteins/immunology ; Gene Expression Profiling/veterinary ; NF-kappa B/immunology ; Nodaviridae/physiology ; Phylogeny ; Proteasome Endopeptidase Complex/chemistry ; RNA Virus Infections/immunology ; RNA Virus Infections/veterinary ; RNA Virus Infections/virology ; Sequence Alignment/veterinary ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
Extreme parsimony in ATP consumption by 20S complexes in the global disassembly of single SNARE complexes.
Autorzy :
Kim C; School of Biological Sciences and Institute for Molecular Biology and Genetics, Seoul National University, Seoul, South Korea.
Shon MJ; School of Biological Sciences and Institute for Molecular Biology and Genetics, Seoul National University, Seoul, South Korea.; Department of Physics, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
Kim SH; School of Biological Sciences and Institute for Molecular Biology and Genetics, Seoul National University, Seoul, South Korea.; Department of Bionanoscience, Kavli Institute of Technology, Delft University of Technology, Delft, the Netherlands.
Eun GS; School of Biological Sciences and Institute for Molecular Biology and Genetics, Seoul National University, Seoul, South Korea.
Ryu JK; Department of Physics, KAIST, Daejeon, South Korea.; Department of Bionanoscience, Kavli Institute of Technology, Delft University of Technology, Delft, the Netherlands.
Hyeon C; Korea Institute for Advanced Study, Seoul, South Korea.
Jahn R; Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany.
Yoon TY; School of Biological Sciences and Institute for Molecular Biology and Genetics, Seoul National University, Seoul, South Korea. .
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Źródło :
Nature communications [Nat Commun] 2021 May 28; Vol. 12 (1), pp. 3206. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Triphosphate/*metabolism
Proteasome Endopeptidase Complex/*metabolism
SNARE Proteins/*metabolism
Animals ; Cattle ; Cricetulus ; Hydrolysis ; Models, Molecular ; N-Ethylmaleimide-Sensitive Proteins/isolation & purification ; N-Ethylmaleimide-Sensitive Proteins/metabolism ; Proteasome Endopeptidase Complex/genetics ; Proteasome Endopeptidase Complex/isolation & purification ; Protein Binding ; Protein Multimerization ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; SNARE Proteins/genetics ; SNARE Proteins/isolation & purification ; Single Molecule Imaging ; Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins/genetics ; Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins/isolation & purification ; Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins/metabolism
Czasopismo naukowe
Tytuł :
Structures of chaperone-associated assembly intermediates reveal coordinated mechanisms of proteasome biogenesis.
Autorzy :
Schnell HM; Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
Walsh RM Jr; Harvard Cryo-Electron Microscopy Center for Structural Biology, Harvard Medical School, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Rawson S; Harvard Cryo-Electron Microscopy Center for Structural Biology, Harvard Medical School, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Kaur M; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, USA.
Bhanu MK; Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
Tian G; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Prado MA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Guerra-Moreno A; Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Roelofs J; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, USA.
Finley D; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Hanna J; Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2021 May; Vol. 28 (5), pp. 418-425. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Molecular Chaperones*/chemistry
Molecular Chaperones*/metabolism
Proteasome Endopeptidase Complex*/chemistry
Proteasome Endopeptidase Complex*/metabolism
Saccharomyces cerevisiae Proteins*/chemistry
Saccharomyces cerevisiae Proteins*/metabolism
Saccharomyces cerevisiae/*metabolism
Catalytic Domain ; Models, Molecular ; Protein Conformation ; Protein Subunits
Czasopismo naukowe
Tytuł :
Structural Fluctuations of the Human Proteasome α7 Homo-Tetradecamer Double Ring Imply the Proteasomal α-Ring Assembly Mechanism.
Autorzy :
Song C; Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.; National Institute for Physiological Sciences, National Institutes of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan.; School of Life Science, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Aichi 444-8787, Japan.
Satoh T; Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.
Sekiguchi T; Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.; Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.; School of Physical Science, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Aichi 444-8787, Japan.; Institute for Molecular Science, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.
Kato K; Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.; Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.; School of Physical Science, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Aichi 444-8787, Japan.; Institute for Molecular Science, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.
Murata K; Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.; National Institute for Physiological Sciences, National Institutes of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan.; School of Life Science, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Aichi 444-8787, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 26; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 26.
Typ publikacji :
Journal Article
MeSH Terms :
Proteasome Endopeptidase Complex/*metabolism
Proteasome Endopeptidase Complex/*ultrastructure
Cryoelectron Microscopy/methods ; Cytoplasm/metabolism ; Humans ; Proteasome Endopeptidase Complex/genetics ; Protein Multimerization/physiology ; Protein Subunits/metabolism
Czasopismo naukowe
Tytuł :
The proteasome: friend and foe of mitochondrial biogenesis.
Autorzy :
Krämer L; Cell Biology, University of Kaiserslautern, Germany.
Groh C; Cell Biology, University of Kaiserslautern, Germany.
Herrmann JM; Cell Biology, University of Kaiserslautern, Germany.
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Źródło :
FEBS letters [FEBS Lett] 2021 Apr; Vol. 595 (8), pp. 1223-1238. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Mitochondria*/genetics
Mitochondria*/metabolism
Mitochondrial Proteins*/genetics
Mitochondrial Proteins*/metabolism
Organelle Biogenesis*
Proteasome Endopeptidase Complex*/genetics
Proteasome Endopeptidase Complex*/metabolism
Proteolysis*
Animals ; Humans
Czasopismo naukowe
Tytuł :
Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP.
Autorzy :
Zheng M; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Huo J; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Gu X; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Wang Y; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wu C; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhang Q; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Wang W; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Liu Y; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Liu Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhou X; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Chen L; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhou Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Li H; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jun 10; Vol. 64 (11), pp. 7839-7852. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
ErbB Receptors/*metabolism
Poly(ADP-ribose) Polymerases/*metabolism
Proteasome Endopeptidase Complex/*metabolism
Protein Kinase Inhibitors/*pharmacology
Proteolysis/*drug effects
Adaptor Proteins, Signal Transducing/chemistry ; Adaptor Proteins, Signal Transducing/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Gefitinib/chemistry ; Humans ; Ligands ; Phthalazines/chemistry ; Piperazines/chemistry ; Proteasome Endopeptidase Complex/genetics ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
The rise of covalent proteolysis targeting chimeras.
Autorzy :
Gabizon R; Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, 7610001, Israel. Electronic address: .
London N; Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, 7610001, Israel. Electronic address: .
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Źródło :
Current opinion in chemical biology [Curr Opin Chem Biol] 2021 Jun; Vol. 62, pp. 24-33. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Chimera/*metabolism
Proteasome Endopeptidase Complex/*chemistry
Ubiquitin-Protein Ligases/*metabolism
Acrylamide/chemistry ; Acrylamide/metabolism ; Adenine/analogs & derivatives ; Adenine/chemistry ; Adenine/metabolism ; Animals ; Drug Discovery ; Humans ; Ligands ; Molecular Docking Simulation ; Piperidines/chemistry ; Piperidines/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Protein Binding ; Protein Conformation ; Proteolysis ; Signal Transduction ; Structure-Activity Relationship ; Ubiquitination
Czasopismo naukowe
Tytuł :
Chronic pain susceptibility is associated with anhedonic behavior and alterations in the accumbal ubiquitin-proteasome system.
Autorzy :
Guimarães MR; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Anjo SI; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Cunha AM; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Esteves M; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Sousa N; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Almeida A; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Manadas B; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Leite-Almeida H; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.
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Źródło :
Pain [Pain] 2021 Jun 01; Vol. 162 (6), pp. 1722-1731.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chronic Pain*
Proteasome Endopeptidase Complex*
Animals ; Proteomics ; Rats ; Rats, Sprague-Dawley ; Ubiquitin
Czasopismo naukowe
Tytuł :
An antibody-based amperometric biosensor for 20S proteasome activity and inhibitor screening.
Autorzy :
Barsan MM; National Institute of Material Physics, 077125, Magurele, Romania. .
Diculescu VC
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Źródło :
The Analyst [Analyst] 2021 May 21; Vol. 146 (10), pp. 3216-3224. Date of Electronic Publication: 2021 Apr 07.
Typ publikacji :
Journal Article
MeSH Terms :
Biosensing Techniques*
Proteasome Endopeptidase Complex*/metabolism
Electrochemical Techniques ; Humans ; Oxidation-Reduction ; Proteolysis
Czasopismo naukowe
Tytuł :
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis.
Autorzy :
Thomas M; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
Brand S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
De Rycker M; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
Zuccotto F; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
Lukac I; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
Dodd PG; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
Ko EJ; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
Manthri S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
McGonagle K; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
Osuna-Cabello M; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
Riley J; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
Pont C; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
Simeons F; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
Stojanovski L; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
Thomas J; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
Thompson S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
Viayna E; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
Fiandor JM; Global Health R&D, GlaxoSmithKline, Tres Cantos 28760, Spain.
Martin J; Global Health R&D, GlaxoSmithKline, Tres Cantos 28760, Spain.
Wyatt PG; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
Miles TJ; Global Health R&D, GlaxoSmithKline, Tres Cantos 28760, Spain.
Read KD; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
Marco M; Global Health R&D, GlaxoSmithKline, Tres Cantos 28760, Spain.
Gilbert IH; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee DD1 5EH, U.K.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 5905-5930. Date of Electronic Publication: 2021 Apr 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Proteasome Endopeptidase Complex/*metabolism
Proteasome Inhibitors/*chemistry
Protozoan Proteins/*metabolism
Animals ; Antiprotozoal Agents/chemistry ; Antiprotozoal Agents/metabolism ; Antiprotozoal Agents/pharmacology ; Antiprotozoal Agents/therapeutic use ; Binding Sites ; Cell Line ; Drug Evaluation, Preclinical ; Half-Life ; Humans ; Leishmania donovani/drug effects ; Leishmania donovani/metabolism ; Leishmaniasis, Visceral/drug therapy ; Leishmaniasis, Visceral/parasitology ; Mice ; Molecular Dynamics Simulation ; Proteasome Endopeptidase Complex/chemistry ; Proteasome Inhibitors/metabolism ; Proteasome Inhibitors/pharmacology ; Proteasome Inhibitors/therapeutic use ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Protozoan Proteins/chemistry ; Pyridines/chemistry ; Pyridines/metabolism ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Solubility ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation.
Autorzy :
Vijayaraj SL; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
Feltham R; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
Rashidi M; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
Frank D; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
Liu Z; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Simpson DS; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
Ebert G; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
Vince A; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Herold MJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
Kueh A; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
Pearson JS; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Microbiology, Monash University, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia.
Dagley LF; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
Murphy JM; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
Webb AI; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
Lawlor KE; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. .; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia. .; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia. .; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia. .
Vince JE; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. .; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia. .
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Źródło :
Nature communications [Nat Commun] 2021 May 11; Vol. 12 (1), pp. 2713. Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Processing, Post-Translational*
Caspase 1/*genetics
Inflammasomes/*genetics
Interleukin-1beta/*genetics
Proteasome Endopeptidase Complex/*genetics
Animals ; Caspase 1/immunology ; HEK293 Cells ; Humans ; Inflammasomes/immunology ; Inflammation ; Interleukin-1beta/immunology ; Lipopolysaccharides/administration & dosage ; Macrophages/immunology ; Macrophages/pathology ; Mice ; Mice, Knockout ; Primary Cell Culture ; Proteasome Endopeptidase Complex/immunology ; Proteolysis ; Reactive Oxygen Species/immunology ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Ubiquitin/genetics ; Ubiquitin/immunology ; Ubiquitination
Czasopismo naukowe
Tytuł :
Altered Phosphorylation of the Proteasome Subunit Rpt6 Has Minimal Impact on Synaptic Plasticity and Learning.
Autorzy :
Scudder SL; Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093-0347.
Gonzales FR; Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093-0347.
Howell KK; Molecular Cognition Laboratory, Department of Psychology, University of California San Diego, La Jolla, CA 92093-0109.
Stein IS; Center for Neuroscience, University of California, Davis, CA 95618-4859.
Dozier LE; Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093-0347.
Anagnostaras SG; Molecular Cognition Laboratory, Department of Psychology, University of California San Diego, La Jolla, CA 92093-0109.
Zito K; Center for Neuroscience, University of California, Davis, CA 95618-4859.
Patrick GN; Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093-0347 .
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Źródło :
ENeuro [eNeuro] 2021 May 05; Vol. 8 (3). Date of Electronic Publication: 2021 May 05 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
ATPases Associated with Diverse Cellular Activities*
Learning*
Neuronal Plasticity*
Proteasome Endopeptidase Complex*
Animals ; Hippocampus/metabolism ; Long-Term Potentiation ; Mice ; Phosphorylation ; Synapses/metabolism
Czasopismo naukowe
Tytuł :
Modulation of the ubiquitin-proteasome system by marine natural products.
Autorzy :
Vasilopoulou MΑ; Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., Athens, 11635, Greece; Department of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 41500, Larisa, Greece. Electronic address: .
Ioannou E; Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens, 15771, Greece. Electronic address: .
Roussis V; Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens, 15771, Greece. Electronic address: .
Chondrogianni N; Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., Athens, 11635, Greece. Electronic address: .
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Źródło :
Redox biology [Redox Biol] 2021 May; Vol. 41, pp. 101897. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Biological Products*
Proteasome Endopeptidase Complex*
Longevity ; Ubiquitin
Czasopismo naukowe

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