Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Ukraiński (UK)
Przejdź do strony domowej biblioteki Uniwersytet Ekonomiczny we Wrocławiu Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaUniwersytet Ekonomiczny we Wrocławiu

Wyszukujesz frazę ""Protein Aggregates"" wg kryterium: Temat

  Lista filtrów
Wyrównaj
Wyświetlanie 1-20 z 169
Tytuł:
ApoE Isoforms Inhibit Amyloid Aggregation of Proinflammatory Protein S100A9.
Autorzy:
Ghosh S; Department of Medical Biochemistry and Biophysics, Umeå University, SE-90187 Umeå, Sweden.
Tamilselvi S; Department of Medical Biochemistry and Biophysics, Umeå University, SE-90187 Umeå, Sweden.
Williams C; Department of Medical and Translational Biology, Umeå University, SE-90187 Umeå, Sweden.
Jayaweera SW; Department of Clinical Microbiology, Umeå University, SE-90187 Umeå, Sweden.
Iashchishyn IA; Department of Medical Biochemistry and Biophysics, Umeå University, SE-90187 Umeå, Sweden.
Šulskis D; Institute of Biotechnology, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania.
Gilthorpe JD; Department of Medical and Translational Biology, Umeå University, SE-90187 Umeå, Sweden.
Olofsson A; Department of Clinical Microbiology, Umeå University, SE-90187 Umeå, Sweden.
Smirnovas V; Institute of Biotechnology, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania.
Svedružić ŽM; Department of Biotechnology, University of Rijeka, HR-51000 Rijeka, Croatia.
Morozova-Roche LA; Department of Medical Biochemistry and Biophysics, Umeå University, SE-90187 Umeå, Sweden.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 09; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Alzheimer Disease*/pathology
Apolipoprotein E4*/genetics
Apolipoproteins E*/genetics
Calgranulin B*/metabolism
Protein Aggregates*
Humans ; Amyloid ; Amyloid beta-Peptides/metabolism ; Apolipoprotein E3 ; Neuroinflammatory Diseases ; Protein Isoforms/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Secondary Modification of S100B Influences Anti Amyloid-β Aggregation Activity and Alzheimer's Disease Pathology.
Autorzy:
Coelho R; BioISI-Instituto de Biosistemas e Ciências Integrativas, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.; Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.
De Benedictis CA; Cellular Neurobiology and Neuro-Nanotechnology Laboratory, Department of Biological Sciences, University of Limerick, V94PH61 Limerick, Ireland.; Bernal Institute, University of Limerick, V94PH61 Limerick, Ireland.
Sauer AK; Cellular Neurobiology and Neuro-Nanotechnology Laboratory, Department of Biological Sciences, University of Limerick, V94PH61 Limerick, Ireland.; Bernal Institute, University of Limerick, V94PH61 Limerick, Ireland.; Health Research Institute (HRI), University of Limerick, V94PH61 Limerick, Ireland.
Figueira AJ; BioISI-Instituto de Biosistemas e Ciências Integrativas, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.; Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.
Faustino H; Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, Portugal.; Association BLC3-Technology and Innovation Campus, Centre Bio R&D Unit, Oliveira do Hospital, Rua Nossa Senhora da Conceição No. 2, 3405-155 Coimbra, Portugal.
Grabrucker AM; Cellular Neurobiology and Neuro-Nanotechnology Laboratory, Department of Biological Sciences, University of Limerick, V94PH61 Limerick, Ireland.; Bernal Institute, University of Limerick, V94PH61 Limerick, Ireland.; Health Research Institute (HRI), University of Limerick, V94PH61 Limerick, Ireland.
Gomes CM; BioISI-Instituto de Biosistemas e Ciências Integrativas, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.; Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 01; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Humans ; Amyloid beta-Peptides/metabolism ; Oxidative Stress ; Protein Aggregates ; Oxidation-Reduction ; S100 Calcium Binding Protein beta Subunit/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Aggregation, Transmission, and Toxicity of the Microtubule-Associated Protein Tau: A Complex Comprehension.
Autorzy:
Hu J; Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Sha W; Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Yuan S; Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Wu J; Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.; Key Laboratory of Systems Biology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou 310024, China.
Huang Y; Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.; Key Laboratory of Systems Biology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou 310024, China.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 09; Vol. 24 (19). Date of Electronic Publication: 2023 Oct 09.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Tauopathies*/metabolism
Alzheimer Disease*/metabolism
Humans ; tau Proteins/metabolism ; Protein Aggregates ; Comprehension
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Unveiling the Effects of Copper Ions in the Aggregation of Amyloidogenic Proteins.
Autorzy:
Oliveri V; Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A Doria 6, 95125 Catania, Italy.
Pokaż więcej
Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Sep 05; Vol. 28 (18). Date of Electronic Publication: 2023 Sep 05.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Amyloidogenic Proteins*
Alzheimer Disease*/metabolism
Humans ; Copper/metabolism ; Protein Folding ; Protein Aggregates ; Amyloid beta-Peptides/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Different Extracellular β-Amyloid (1-42) Aggregates Differentially Impair Neural Cell Adhesion and Neurite Outgrowth through Differential Induction of Scaffold Palladin.
Autorzy:
Zhang T; Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun 130012, China.
Song C; Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun 130012, China.
Li H; Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun 130012, China.
Zheng Y; School of Life Science, Jilin University, Changchun 130012, China.
Zhang Y; Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun 130012, China.; School of Life Science, Jilin University, Changchun 130012, China.
Pokaż więcej
Źródło:
Biomolecules [Biomolecules] 2022 Dec 02; Vol. 12 (12). Date of Electronic Publication: 2022 Dec 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyloid beta-Peptides*/metabolism
Neuronal Outgrowth*
Protein Aggregates*
Alzheimer Disease*/metabolism
Humans ; Cell Adhesion ; Cytoskeletal Proteins ; Cell Line, Tumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeting Protein Aggregates with Natural Products: An Optional Strategy for Neurodegenerative Diseases.
Autorzy:
Xiang L; State Key Laboratory of Subtropical Silviculture, School of Forestry and Biotechnology, Zhejiang A&F University, Hangzhou 311300, China.
Wang Y; State Key Laboratory of Subtropical Silviculture, School of Forestry and Biotechnology, Zhejiang A&F University, Hangzhou 311300, China.
Liu S; State Key Laboratory of Subtropical Silviculture, School of Forestry and Biotechnology, Zhejiang A&F University, Hangzhou 311300, China.
Liu B; State Key Laboratory of Subtropical Silviculture, School of Forestry and Biotechnology, Zhejiang A&F University, Hangzhou 311300, China.; Department of Chemistry and Molecular Biology, University of Gothenburg, 41390 Gothenburg, Sweden.
Jin X; State Key Laboratory of Subtropical Silviculture, School of Forestry and Biotechnology, Zhejiang A&F University, Hangzhou 311300, China.
Cao X; State Key Laboratory of Subtropical Silviculture, School of Forestry and Biotechnology, Zhejiang A&F University, Hangzhou 311300, China.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 10; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 10.
Typ publikacji:
Systematic Review; Journal Article; Review
MeSH Terms:
Neurodegenerative Diseases*/metabolism
Biological Products*/pharmacology
Biological Products*/therapeutic use
Parkinson Disease*
Alzheimer Disease*
Humans ; Protein Aggregates
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Unconventional Source of Neurotoxic Protein Aggregation from Organelle Off-Target Bax∆2 in Alzheimer's Disease.
Autorzy:
Yao Q; Department of Biology, Illinois Institute of Technology, Chicago, IL 60616, USA.
Mascarenhas Dos Santos AC; Department of Biology, Illinois Institute of Technology, Chicago, IL 60616, USA.
Zhang H; Department of Biology, Illinois Institute of Technology, Chicago, IL 60616, USA.
Mañas A; Department of Laboratory Medicine, Lund University, 22381 Lund, Sweden.
Hussaini A; Department of Biology, Illinois Institute of Technology, Chicago, IL 60616, USA.
Kim U; Department of Biology, Illinois Institute of Technology, Chicago, IL 60616, USA.
Xu C; Department of Biology, Illinois Institute of Technology, Chicago, IL 60616, USA.
Basheer S; Department of Biology, Illinois Institute of Technology, Chicago, IL 60616, USA.
Tasaki S; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
Xiang J; Department of Biology, Illinois Institute of Technology, Chicago, IL 60616, USA.
Pokaż więcej
Źródło:
Biomolecules [Biomolecules] 2023 Jun 10; Vol. 13 (6). Date of Electronic Publication: 2023 Jun 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Alzheimer Disease*/metabolism
Neurotoxicity Syndromes*
Humans ; Protein Aggregates ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism ; Amyloid beta-Peptides/metabolism ; Mitochondria/metabolism ; tau Proteins/genetics ; tau Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Thiophene-Based Ligands for Histological Multiplex Spectral Detection of Distinct Protein Aggregates in Alzheimer's Disease.
Autorzy:
Lantz L; Department of Physics, Chemistry and Biology, Linköping University, 581 83, Linköping, Sweden.
Shirani H; Department of Physics, Chemistry and Biology, Linköping University, 581 83, Linköping, Sweden.
Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, 46202, Indiana, USA.
Vidal R; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, 46202, Indiana, USA.
Klingstedt T; Department of Physics, Chemistry and Biology, Linköping University, 581 83, Linköping, Sweden.
Nilsson KPR; Department of Physics, Chemistry and Biology, Linköping University, 581 83, Linköping, Sweden.
Pokaż więcej
Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Apr 13; Vol. 29 (21), pp. e202203568. Date of Electronic Publication: 2023 Mar 08.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Humans ; Protein Aggregates ; Thiophenes/chemistry ; Ligands ; Amyloid beta-Peptides/chemistry ; Brain/metabolism ; tau Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Lipoprotein Metabolism, Protein Aggregation, and Alzheimer's Disease: A Literature Review.
Autorzy:
Grao-Cruces E; Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Seville, 41009 Sevilla, Spain.
Claro-Cala CM; Department of Pharmacology, Pediatrics, and Radiology, School of Medicine, University of Seville, 41009 Sevilla, Spain.
Montserrat-de la Paz S; Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Seville, 41009 Sevilla, Spain.
Nobrega C; ABC-RI-Algarve Biomedical Center Research Institute, Faculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, Portugal.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 02; Vol. 24 (3). Date of Electronic Publication: 2023 Feb 02.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alzheimer Disease*/metabolism
Humans ; Protein Aggregates ; Neurofibrillary Tangles/metabolism ; Brain/metabolism ; Lipoproteins/metabolism ; tau Proteins/metabolism ; Amyloid beta-Peptides/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interplay of Ferritin Accumulation and Ferroportin Loss in Ageing Brain: Implication for Protein Aggregation in Down Syndrome Dementia, Alzheimer's, and Parkinson's Diseases.
Autorzy:
Raha AA; John van Geest Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge CB2 2PY, UK.; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.
Biswas A; Department of Biochemistry, The M. S. University of Baroda, Vadodara 39002, India.
Henderson J; John van Geest Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge CB2 2PY, UK.
Chakraborty S; John van Geest Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge CB2 2PY, UK.; NIHR Biomedical Research Centre, Moorfields Eye Hospital and UCL Institute of Ophthalmology, London EC1V 9EL, UK.
Holland A; Cambridge Intellectual & Developmental Disabilities Research Group, Department of Psychiatry, University of Cambridge, Cambridge CB2 8AH, UK.
Friedland RP; Department of Neurology, School of Medicine University of Louisville, Louisville, KY 40292, USA.
Mukaetova-Ladinska E; Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester LE1 7RH, UK.
Zaman S; Cambridge Intellectual & Developmental Disabilities Research Group, Department of Psychiatry, University of Cambridge, Cambridge CB2 8AH, UK.
Raha-Chowdhury R; John van Geest Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge CB2 2PY, UK.; Cambridge Intellectual & Developmental Disabilities Research Group, Department of Psychiatry, University of Cambridge, Cambridge CB2 8AH, UK.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 19; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Down Syndrome*/complications
Down Syndrome*/metabolism
Neurodegenerative Diseases*/metabolism
Parkinson Disease*/metabolism
Protein Aggregates*
Brain/metabolism ; Cation Transport Proteins ; Ferritins/metabolism ; Hepcidins/metabolism ; Humans ; Iron/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Development of naringenin- O -alkylamine derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Autorzy:
Yang J; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Zhou Y; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Ban Y; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, China.
Mi J; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
He Y; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Li X; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Liu Z; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Wang K; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Zhu G; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, China.
Liu W; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Tan Z; Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan Academy of Chinese Medicine Sciences, Chengdu, China.
Sang Z; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, China.
Pokaż więcej
Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 792-816.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease/*drug therapy
Amines/*pharmacology
Antioxidants/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Flavanones/*pharmacology
Neuroprotective Agents/*pharmacology
Acetylcholinesterase/metabolism ; Alzheimer Disease/metabolism ; Amines/chemical synthesis ; Amines/chemistry ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Animals ; Antioxidants/chemical synthesis ; Antioxidants/chemistry ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Butyrylcholinesterase/metabolism ; Cell Line ; Cell Survival/drug effects ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Drug Development ; Flavanones/chemical synthesis ; Flavanones/chemistry ; Humans ; Mice ; Molecular Structure ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; Protein Aggregates/drug effects ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Design, synthesis, and evaluation of novel O -alkyl ferulamide derivatives as multifunctional ligands for treating Alzheimer's disease.
Autorzy:
Zhu G; State Key Laboratory of Functions and Applications of Medicinal Plants, School of Basic Medical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, China.
Bai P; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Wang K; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Mi J; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Yang J; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Hu J; State Key Laboratory of Functions and Applications of Medicinal Plants, School of Basic Medical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, China.
Ban Y; State Key Laboratory of Functions and Applications of Medicinal Plants, School of Basic Medical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, China.
Xu R; State Key Laboratory of Functions and Applications of Medicinal Plants, School of Basic Medical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, China.
Chen R; State Key Laboratory of Functions and Applications of Medicinal Plants, School of Basic Medical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, China.
Wang C; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Tang L; State Key Laboratory of Functions and Applications of Medicinal Plants, School of Basic Medical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, China.
Sang Z; State Key Laboratory of Functions and Applications of Medicinal Plants, School of Basic Medical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, China.; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.
Pokaż więcej
Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 1375-1388.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Neuroprotective Agents*
Acetylcholinesterase/metabolism ; Amyloid beta-Peptides ; Cholinesterase Inhibitors/pharmacology ; Drug Design ; Humans ; Ligands ; Molecular Structure ; Positron Emission Tomography Computed Tomography ; Protein Aggregates ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer's disease.
Autorzy:
Sang Z; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.; Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
Song Q; Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
Cao Z; Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
Deng Y; Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
Zhang L; Department of Elderly Digestive, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu, China.
Pokaż więcej
Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 69-85.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Design*
Alzheimer Disease/*drug therapy
Antioxidants/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Monoamine Oxidase Inhibitors/*pharmacology
Neuroprotective Agents/*pharmacology
Acetylcholinesterase/metabolism ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Animals ; Antioxidants/chemical synthesis ; Antioxidants/chemistry ; Chalcone/chemistry ; Chalcone/pharmacology ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Electrophorus ; Humans ; Ligands ; Molecular Structure ; Monoamine Oxidase/metabolism ; Monoamine Oxidase Inhibitors/chemical synthesis ; Monoamine Oxidase Inhibitors/chemistry ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; PC12 Cells ; Protein Aggregates/drug effects ; Rats ; Structure-Activity Relationship ; Vitamin E/chemistry ; Vitamin E/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Small Heat Shock Proteins Collaborate with FAIM to Prevent Accumulation of Misfolded Protein Aggregates.
Autorzy:
Kaku H; Department of Investigative Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI 49007, USA.
Balaj AR; Department of Investigative Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI 49007, USA.
Rothstein TL; Department of Investigative Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI 49007, USA.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Oct 06; Vol. 23 (19). Date of Electronic Publication: 2022 Oct 06.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*
Apoptosis Regulatory Proteins*/metabolism
Heat-Shock Proteins, Small*/metabolism
Amyloid beta-Peptides/metabolism ; Detergents ; HSP27 Heat-Shock Proteins/metabolism ; Humans ; Protein Aggregates
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Dual-probe fluorescence spectroscopy for sensitive quantitation of Alzheimer's amyloid pathology.
Autorzy:
Stepanchuk AA; Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Morgan ML; Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Joseph JT; Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Pathology and Laboratory Medicine, Alberta Health Services, Calgary, AB, Canada.
Stys PK; Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. .
Pokaż więcej
Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2022 Oct 28; Vol. 10 (1), pp. 153. Date of Electronic Publication: 2022 Oct 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/pathology
Amyloidosis*/pathology
Animals ; Humans ; Mice ; Amyloid beta-Peptides/metabolism ; tau Proteins/metabolism ; Protein Aggregates ; Spectrometry, Fluorescence ; Plaque, Amyloid/pathology ; Amyloid/metabolism ; Brain/pathology ; Fluorescent Dyes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Andrographolide Attenuates Short-Term Spatial and Recognition Memory Impairment and Neuroinflammation Induced by a Streptozotocin Rat Model of Alzheimer's Disease.
Autorzy:
Souza LC; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil. .
Andrade MK; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil.
Azevedo EM; Department of Physiology, Federal University of Paraná, Curitiba, PR, Brazil.
Ramos DC; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil.
Bail EL; Department of Physiology, Federal University of Paraná, Curitiba, PR, Brazil.
Vital MABF; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil.
Pokaż więcej
Źródło:
Neurotoxicity research [Neurotox Res] 2022 Oct; Vol. 40 (5), pp. 1440-1454. Date of Electronic Publication: 2022 Aug 27.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/chemically induced
Alzheimer Disease*/drug therapy
Diterpenes*/pharmacology
Diterpenes*/therapeutic use
Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/pharmacology ; Animals ; Antioxidants/pharmacology ; Calcium ; Disease Models, Animal ; Glial Fibrillary Acidic Protein ; Lactones/adverse effects ; Maze Learning ; Memory Disorders/chemically induced ; Memory Disorders/drug therapy ; Memory Disorders/metabolism ; Neuroinflammatory Diseases ; Protein Aggregates ; Rats ; Rats, Wistar ; Streptozocin/toxicity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Role of the Cysteine in R3 Tau Peptide in Copper Binding and Reactivity.
Autorzy:
Bacchella C; Dipartimento di Chimica, Università di Pavia, Via Taramelli 12, 27100 Pavia, Italy.
Gentili S; Dipartimento di Scienze Chimiche, della Vita e della Sostenibilità Ambientale, Università di Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.
Mozzi SI; Dipartimento di Chimica, Università di Pavia, Via Taramelli 12, 27100 Pavia, Italy.
Monzani E; Dipartimento di Chimica, Università di Pavia, Via Taramelli 12, 27100 Pavia, Italy.
Casella L; Dipartimento di Chimica, Università di Pavia, Via Taramelli 12, 27100 Pavia, Italy.
Tegoni M; Dipartimento di Scienze Chimiche, della Vita e della Sostenibilità Ambientale, Università di Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.
Dell'Acqua S; Dipartimento di Chimica, Università di Pavia, Via Taramelli 12, 27100 Pavia, Italy.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 14; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 14.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
tau Proteins*/metabolism
Alanine ; Copper/metabolism ; Cysteine ; Disulfides ; Dopamine ; Humans ; Peptides/chemistry ; Protein Aggregates
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Interplay of Apoes with Syndecans in Influencing Key Cellular Events of Amyloid Pathology.
Autorzy:
Hudák A; Pharmacoidea Ltd., H-6726 Szeged, Hungary.
Jósvay K; Institute of Biochemistry, Biological Research Centre, H-6726 Szeged, Hungary.
Domonkos I; Institute of Plant Biology, Biological Research Centre, H-6726 Szeged, Hungary.
Letoha A; Department of Medicine, Albert Szent-Györgyi Clinical Center, Faculty of Medicine, University of Szeged, H-6725 Szeged, Hungary.
Szilák L; Pharmacoidea Ltd., H-6726 Szeged, Hungary.
Letoha T; Pharmacoidea Ltd., H-6726 Szeged, Hungary.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 30; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 30.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Aggregates*
Alzheimer Disease/*metabolism
Amyloid beta-Peptides/*metabolism
Apolipoprotein E2/*metabolism
Apolipoprotein E4/*metabolism
Apolipoproteins E/*metabolism
Syndecan-3/*metabolism
Cell Line, Tumor ; Humans ; Protein Isoforms
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tau Seeding Mouse Models with Patient Brain-Derived Aggregates.
Autorzy:
Robert A; Department of Neurodegenerative Disease, UCL Queen Square, Institute of Neurology, University College London, London WC1N 3BG, UK.
Schöll M; Department of Neurodegenerative Disease, UCL Queen Square, Institute of Neurology, University College London, London WC1N 3BG, UK.; Wallenberg Centre for Molecular and Translational Medicine and the Department of Psychiatry and Neurochemistry, University of Gothenburg, 413 45 Gothenburg, Sweden.; Department of Psychiatry and Neurochemistry, University of Gothenburg, 413 45 Gothenburg, Sweden.
Vogels T; Department of Neurodegenerative Disease, UCL Queen Square, Institute of Neurology, University College London, London WC1N 3BG, UK.; Department of Psychiatry and Neurochemistry, University of Gothenburg, 413 45 Gothenburg, Sweden.; Sylics (Synaptologics B.V.), 3721 MA Bilthoven, The Netherlands.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 07; Vol. 22 (11). Date of Electronic Publication: 2021 Jun 07.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Disease Models, Animal*
Protein Aggregates*
Alzheimer Disease/*pathology
Brain/*pathology
Tauopathies/*pathology
tau Proteins/*metabolism
Alzheimer Disease/metabolism ; Animals ; Brain/metabolism ; Humans ; Mice ; Tauopathies/metabolism ; tau Proteins/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Methylation as a key regulator of Tau aggregation and neuronal health in Alzheimer's disease.
Autorzy:
Balmik AA; Neurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, 411008,, Pune, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002,, India.
Chinnathambi S; Neurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, 411008,, Pune, India. .; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002,, India. .
Pokaż więcej
Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2021 May 07; Vol. 19 (1), pp. 51. Date of Electronic Publication: 2021 May 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Protein Aggregates*
Alzheimer Disease/*metabolism
Neurons/*metabolism
Neurons/*pathology
tau Proteins/*metabolism
Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amino Acid Sequence ; Epigenesis, Genetic ; Humans ; Methylation ; tau Proteins/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 169

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies