Temat: "Protein Aggregates" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Membrane Curvature: The Inseparable Companion of Autophagy.
Autorzy:: Liu L; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China.; National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, China.
Tang Y; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China.; National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, China.
Zhou Z; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China.; National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, China.
Huang Y; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China.
Zhang R; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China.
Lyu H; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China.
Xiao S; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China.
Guo D; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China.
Ali DW; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Michalak M; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Chen XZ; Membrane Protein Disease Research Group, Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Zhou C; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China.
Tang J; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China.; Pokaż więcej
Źródło:: Cells [Cells] 2023 Apr 11; Vol. 12 (8). Date of Electronic Publication: 2023 Apr 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Autophagy*
Cell Membrane*/chemistry
Cell Membrane*/metabolism
Proteolysis*
Autophagosomes*/chemistry
Autophagosomes*/metabolism
Autophagy-Related Proteins*/chemistry
Autophagy-Related Proteins*/metabolism
Protein Aggregates ; Protein Domains ; Lipid Bilayers ; Humans

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Skocz do pozycji: 2.

Tytuł:: Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient-induced pluripotent stem cell-derived retinal pigment epithelium cells.
Autorzy:: Georgiou M; Newcastle University Biosciences Institute, Newcastle upon Tyne, UK.
Yang C; Newcastle University Biosciences Institute, Newcastle upon Tyne, UK.
Atkinson R; Newcastle University Biosciences Institute, Newcastle upon Tyne, UK.
Pan KT; Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Buskin A; Newcastle University Biosciences Institute, Newcastle upon Tyne, UK.
Molina MM; Newcastle University Biosciences Institute, Newcastle upon Tyne, UK.
Collin J; Newcastle University Biosciences Institute, Newcastle upon Tyne, UK.
Al-Aama J; Faculty of Medicine, King Abdulaziz University, Saudi Arabia.
Goertler F; Department of Biological Sciences, University of Bergen, Norway.
Ludwig SEJ; Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Davey T; Newcastle University Biosciences Institute, Newcastle upon Tyne, UK.
Lührmann R; Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Nagaraja-Grellscheid S; Department of Biological Sciences, University of Bergen, Norway.; Department of Biosciences, Durham, UK.
Johnson CA; Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK.
Ali R; King's College, London, UK.
Armstrong L; Newcastle University Biosciences Institute, Newcastle upon Tyne, UK.
Korolchuk V; Newcastle University Biosciences Institute, Newcastle upon Tyne, UK.
Urlaub H; Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Bioanalytics, Department of Clinical Chemistry, University Medical Center, Goettingen, Germany.
Mozaffari-Jovin S; Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Lako M; Newcastle University Biosciences Institute, Newcastle upon Tyne, UK.; Pokaż więcej
Źródło:: Clinical and translational medicine [Clin Transl Med] 2022 Mar; Vol. 12 (3), pp. e759.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Autophagy*
Eye Proteins*/genetics
Eye Proteins*/metabolism
Induced Pluripotent Stem Cells*/metabolism
Protein Aggregates*
Retinitis Pigmentosa*/genetics
Retinitis Pigmentosa*/metabolism
Humans ; Retinal Pigment Epithelium/cytology ; Retinal Pigment Epithelium/metabolism ; Ribonucleoproteins, Small Nuclear

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Skocz do pozycji: 3.

Tytuł:: Oligomerization of Selective Autophagy Receptors for the Targeting and Degradation of Protein Aggregates.
Autorzy:: Chen W; Department of Neurosurgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.; Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan 030012, China.
Shen T; Department of Neurosurgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Wang L; Department of Neurosurgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Lu K; Department of Neurosurgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.; Pokaż więcej
Źródło:: Cells [Cells] 2021 Aug 05; Vol. 10 (8). Date of Electronic Publication: 2021 Aug 05.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Autophagy*
Protein Aggregates*
Proteostasis*
Autophagosomes/*metabolism
Autophagy-Related Proteins/*metabolism
Proteasome Endopeptidase Complex/*metabolism
Animals ; Humans ; Protein Multimerization ; Proteolysis ; Signal Transduction ; Structure-Activity Relationship ; Ubiquitination

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Skocz do pozycji: 4.

Tytuł:: Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells.
Autorzy:: Panda C; Biological Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar 382355, India.; Institute of Neuroanatomy, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.
Voelz C; Institute of Neuroanatomy, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.
Habib P; Department of Neurology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.
Mevissen C; Institut für Organische Chemie, RWTH Aachen University, 52074 Aachen, Germany.
Pufe T; Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.
Beyer C; Institute of Neuroanatomy, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.
Gupta S; Biological Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar 382355, India.
Slowik A; Institute of Neuroanatomy, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.; Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2021 Jun 30; Vol. 10 (7). Date of Electronic Publication: 2021 Jun 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Autophagy*/drug effects
Protein Aggregates*
Inflammasomes/*metabolism
Microglia/*cytology
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Oligopeptides/*pharmacology
tau Proteins/*pharmacology
Beclin-1/metabolism ; Biomarkers/metabolism ; CARD Signaling Adaptor Proteins/genetics ; CARD Signaling Adaptor Proteins/metabolism ; Caspase 1/metabolism ; Cell Line ; Cell Survival/drug effects ; Cytokines/metabolism ; Humans ; Interleukin-18/genetics ; Interleukin-18/metabolism ; Microglia/drug effects ; Microglia/metabolism ; Microtubule-Associated Proteins/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Sequestosome-1 Protein/metabolism ; Time Factors ; Up-Regulation/drug effects

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Skocz do pozycji: 5.

Tytuł:: Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes.
Autorzy:: Liu X; Department of Pharmacology, School of Basic Medical Science, Fudan University, Shanghai, China.; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Brain Tumor Center, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America.
Yin L; Department of Pharmacology, School of Basic Medical Science, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Bioactive Small Molecules, Fudan University, Shanghai, China.
Li T; Department of Pharmacology, School of Basic Medical Science, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Bioactive Small Molecules, Fudan University, Shanghai, China.
Lin L; Department of Pharmacology, School of Basic Medical Science, Fudan University, Shanghai, China.
Zhang J; Department of Pharmacology, School of Basic Medical Science, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Bioactive Small Molecules, Fudan University, Shanghai, China.
Li Y; Department of Pharmacology, School of Basic Medical Science, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Bioactive Small Molecules, Fudan University, Shanghai, China.; Pokaż więcej
Źródło:: PLoS genetics [PLoS Genet] 2021 Mar 17; Vol. 17 (3), pp. e1009415. Date of Electronic Publication: 2021 Mar 17 (Print Publication: 2021).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication
MeSH Terms:: Phenotype*
Protein Aggregates*
Autophagy/*genetics
Nerve Tissue Proteins/*genetics
Nerve Tissue Proteins/*metabolism
Protein Aggregation, Pathological/*genetics
Protein Aggregation, Pathological/*metabolism
Autophagy-Related Protein 12/metabolism ; Autophagy-Related Protein 5/metabolism ; Carrier Proteins ; Cell Survival/genetics ; Disease Susceptibility ; Fluorescent Antibody Technique ; Gene Expression ; Humans ; Models, Biological ; Mutation ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Neurons/metabolism ; Protein Binding

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Skocz do pozycji: 6.

Tytuł:: Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability.
Autorzy:: Chen CM; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33302, Taiwan.
Lin CH; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33302, Taiwan.
Wu YR; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33302, Taiwan.
Yen CY; Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Huang YT; Taipei First Girls High School, Taipei 10045, Taiwan.
Lin JL; Taipei First Girls High School, Taipei 10045, Taiwan.
Lin CY; Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Taoyuan 33302, Taiwan.
Chen WL; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33302, Taiwan.
Chao CY; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33302, Taiwan.
Lee-Chen GJ; Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Su MT; Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Chang KH; Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33302, Taiwan.; Pokaż więcej
Źródło:: Cells [Cells] 2020 May 16; Vol. 9 (5). Date of Electronic Publication: 2020 May 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Protein Aggregates*/drug effects
Up-Regulation*/drug effects
Autophagy/*drug effects
Lactulose/*pharmacology
Melibiose/*pharmacology
Neurons/*metabolism
alpha-Synuclein/*metabolism
Amino Acid Sequence ; Antioxidants/pharmacology ; Benzothiazoles/metabolism ; Cell Line ; Cell Survival/drug effects ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Fluorescence ; Green Fluorescent Proteins/metabolism ; Humans ; Lactulose/chemistry ; Melibiose/chemistry ; Neuronal Outgrowth/drug effects ; Neurons/drug effects ; Neuroprotective Agents/pharmacology ; Oxidative Stress/drug effects ; Trehalose/chemistry ; Trehalose/pharmacology ; alpha-Synuclein/chemistry

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Skocz do pozycji: 7.

Tytuł:: Late-in-life treadmill training rejuvenates autophagy, protein aggregate clearance, and function in mouse hearts.
Autorzy:: Cho JM; Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.
Park SK; Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.
Ghosh R; Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.
Ly K; Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.
Ramous C; Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.
Thompson L; Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.
Hansen M; Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.
Mattera MSLC; School of Dentistry, Sao Paulo State University, Aracatuba, Brazil.
Pires KM; Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.
Ferhat M; Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.
Mookherjee S; Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.
Whitehead KJ; Molecular Medicine Program, University of Utah, Salt Lake City, Utah, USA.; Division of Cardiovascular Medicine and Pediatric Cardiology, University of Utah, Salt Lake City, Utah, USA.; George E Wahlen VA Medical Center, University of Utah, Salt Lake City, Utah, USA.
Carter K; Molecular Medicine Program, University of Utah, Salt Lake City, Utah, USA.
Buffolo M; Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.
Boudina S; Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.; Molecular Medicine Program, University of Utah, Salt Lake City, Utah, USA.
Symons JD; Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.; Molecular Medicine Program, University of Utah, Salt Lake City, Utah, USA.; Pokaż więcej
Źródło:: Aging cell [Aging Cell] 2021 Oct; Vol. 20 (10), pp. e13467. Date of Electronic Publication: 2021 Sep 23.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Autophagy/*physiology
Heart/*physiopathology
Physical Conditioning, Animal/*methods
Protein Aggregates/*physiology
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aging ; Animals ; Humans ; Male ; Mice ; Middle Aged ; Young Adult

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Skocz do pozycji: 8.

Tytuł:: Selective autophagy of cytosolic protein aggregates involves ribosome-free rough endoplasmic reticulum.
Autorzy:: Park S; Biozentrum, University of Basel, 4056, Basel, Switzerland.; Department of Integrated OMICS for Biomedical Science, WCU Program of Graduate School, Yonsei University, Seoul, 120-749, South Korea.
Zuber C; Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, 8091, Zurich, Switzerland.
Roth J; Department of Integrated OMICS for Biomedical Science, WCU Program of Graduate School, Yonsei University, Seoul, 120-749, South Korea. .; Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, 8091, Zurich, Switzerland. .; Pokaż więcej
Źródło:: Histochemistry and cell biology [Histochem Cell Biol] 2020 Feb; Vol. 153 (2), pp. 89-99. Date of Electronic Publication: 2019 Nov 12.
Typ publikacji:: Journal Article
MeSH Terms:: Autophagy*
Protein Aggregates*
Carrier Proteins/*chemistry
Cytosol/*chemistry
Endoplasmic Reticulum, Rough/*chemistry
Carrier Proteins/metabolism ; Cytosol/metabolism ; Endoplasmic Reticulum, Rough/metabolism ; Hep G2 Cells ; Humans

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Skocz do pozycji: 9.

Tytuł:: n -Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway.
Autorzy:: Lee JH; Everfront Biotech Inc., New Taipei City 22180, Taiwan.; Department of Life Science, Graduate Institute of Biotechnology, National Dong-Hwa University, Hualien 97447, Taiwan.
Lin SY; Everfront Biotech Inc., New Taipei City 22180, Taiwan.; Department of Life Science, Graduate Institute of Biotechnology, National Dong-Hwa University, Hualien 97447, Taiwan.
Liu JW; Everfront Biotech Inc., New Taipei City 22180, Taiwan.; Department of Life Science, Graduate Institute of Biotechnology, National Dong-Hwa University, Hualien 97447, Taiwan.
Lin SZ; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien 97002, Taiwan.; Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien 97002, Taiwan.
Harn HJ; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien 97002, Taiwan.; Department of Pathology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien 97002, Taiwan.
Chiou TW; Department of Life Science, Graduate Institute of Biotechnology, National Dong-Hwa University, Hualien 97447, Taiwan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jun 13; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 13.
Typ publikacji:: Journal Article
MeSH Terms:: Autophagy*/drug effects
Signal Transduction*/drug effects
Machado-Joseph Disease/*drug therapy
Machado-Joseph Disease/*pathology
Phthalic Anhydrides/*therapeutic use
TOR Serine-Threonine Kinases/*metabolism
Adenylate Kinase/metabolism ; Animals ; Ataxin-3/genetics ; Cerebellum/pathology ; Female ; HEK293 Cells ; Humans ; MAP Kinase Signaling System/drug effects ; Machado-Joseph Disease/physiopathology ; Mice, Inbred C57BL ; Motor Activity/drug effects ; Mutation/genetics ; Phthalic Anhydrides/pharmacology ; Protein Aggregates/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Purkinje Cells/drug effects ; Purkinje Cells/pathology ; Mice

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Skocz do pozycji: 10.

Tytuł:: Broad and Complex Roles of NBR1-Mediated Selective Autophagy in Plant Stress Responses.
Autorzy:: Zhang Y; Department of Landscape and Horticulture, Ecology College, Lishui University, Lishui 323000, Zhejiang, China.; Department of Botany and Plant Pathology and Purdue Center for Plant Biology, 915 W. State Street, Purdue University, West Lafayette, IN 47907-2054, USA.
Chen Z; Department of Botany and Plant Pathology and Purdue Center for Plant Biology, 915 W. State Street, Purdue University, West Lafayette, IN 47907-2054, USA.; Pokaż więcej
Źródło:: Cells [Cells] 2020 Nov 30; Vol. 9 (12). Date of Electronic Publication: 2020 Nov 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms:: Arabidopsis Proteins/*metabolism
Autophagy/*physiology
Carrier Proteins/*metabolism
Stress, Physiological/*physiology
Animals ; Humans ; Protein Aggregates/physiology ; Signal Transduction/physiology

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Skocz do pozycji: 11.

Tytuł:: Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target Cells.
Autorzy:: Cicardi ME; Department of Excellence: Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy.
Cristofani R; Department of Excellence: Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy.
Rusmini P; Department of Excellence: Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy.
Meroni M; Department of Excellence: Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy.
Ferrari V; Department of Excellence: Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy.
Vezzoli G; Department of Excellence: Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy.
Tedesco B; Department of Excellence: Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy.
Piccolella M; Department of Excellence: Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy.
Messi E; Department of Excellence: Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy.
Galbiati M; Department of Excellence: Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy.
Boncoraglio A; Department of Excellence: Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy.
Carra S; Dipartimento di Scienze Biomediche, Metaboliche e Neuroscienze, Università degli Studi di Modena e Reggio Emilia, and Center for Neuroscience and Neurotechnology, Modena, Italy.
Crippa V; Department of Excellence: Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy.
Poletti A; Department of Excellence: Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy. .; Centro InterUniversitario sulle Malattie Neurodegenerative, Università degli Studi di Firenze, Genova, Roma Tor Vergata and Milano, Italy. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2018 Aug 17; Vol. 8 (1), pp. 12390. Date of Electronic Publication: 2018 Aug 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Autophagy*/genetics
Protein Aggregates*
Amyotrophic Lateral Sclerosis/*metabolism
Amyotrophic Lateral Sclerosis/*pathology
DNA-Binding Proteins/*metabolism
Peptide Fragments/*metabolism
Proteasome Endopeptidase Complex/*metabolism
Protein Aggregation, Pathological/*metabolism
Amyotrophic Lateral Sclerosis/etiology ; DNA-Binding Proteins/genetics ; Humans ; Motor Neurons/metabolism ; Muscle Cells/metabolism ; Peptide Fragments/genetics

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Skocz do pozycji: 12.

Tytuł:: Spatiotemporal analysis of soluble aggregates and autophagy markers in the R6/2 mouse model.
Autorzy:: Kumar MJV; Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India.
Shah D; Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India.
Giridharan M; Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India.
Yadav N; Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India.
Manjithaya R; Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India. .; Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India. .
Clement JP; Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Jan 08; Vol. 11 (1), pp. 96. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Autophagy*
Huntingtin Protein/*metabolism
Huntington Disease/*physiopathology
Animals ; Disease Models, Animal ; Female ; Humans ; Huntingtin Protein/chemistry ; Huntingtin Protein/genetics ; Huntington Disease/genetics ; Huntington Disease/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/cytology ; Neurons/metabolism ; Protein Aggregates ; Spatio-Temporal Analysis

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Skocz do pozycji: 13.

Tytuł:: Inhibition of deubiquitination by PR-619 induces apoptosis and autophagy via ubi-protein aggregation-activated ER stress in oesophageal squamous cell carcinoma.
Autorzy:: Wang L; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Li M; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Sha B; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Hu X; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Sun Y; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Zhu M; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Xu Y; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Li P; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Wang Y; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Guo Y; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Li J; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Shi J; Precision Medicine Center, Henan Institute of Medical and Pharmaceutical Sciences & BGI College, Zhengzhou University, Zhengzhou, China.
Li P; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Hu T; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Chen P; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.; Henan Key Laboratory of Precision Clinical Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Pokaż więcej
Źródło:: Cell proliferation [Cell Prolif] 2021 Jan; Vol. 54 (1), pp. e12919. Date of Electronic Publication: 2020 Oct 31.
Typ publikacji:: Journal Article
MeSH Terms:: Aminopyridines/*pharmacology
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Autophagy/*drug effects
Endoplasmic Reticulum Stress/*drug effects
Esophageal Neoplasms/*drug therapy
Esophageal Squamous Cell Carcinoma/*drug therapy
Thiocyanates/*pharmacology
Ubiquitination/*drug effects
Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/metabolism ; Esophageal Squamous Cell Carcinoma/pathology ; Humans ; Protein Aggregates/drug effects ; Tumor Cells, Cultured ; Ubiquitin/antagonists & inhibitors ; Ubiquitin/metabolism

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Skocz do pozycji: 14.

Tytuł:: The Roles of Ubiquitin in Mediating Autophagy.
Autorzy:: Yin Z; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Popelka H; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Lei Y; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Yang Y; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Klionsky DJ; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.; Pokaż więcej
Źródło:: Cells [Cells] 2020 Sep 02; Vol. 9 (9). Date of Electronic Publication: 2020 Sep 02.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms:: Protein Processing, Post-Translational*
Autophagy/*genetics
Autophagy-Related Proteins/*genetics
Lysosomes/*metabolism
Ubiquitin/*genetics
Ubiquitin-Protein Ligases/*genetics
Autophagy-Related Proteins/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Protein Aggregates/genetics ; Proteolysis ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination

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Skocz do pozycji: 15.

Tytuł:: Impairment of Proteasome and Autophagy Underlying the Pathogenesis of Leukodystrophy.
Autorzy:: Lin DS; Department of Pediatrics, Mackay Memorial Hospital, Taipei 10449, Taiwan.; Department of Medicine and Institute of Biomedical Sciences, Mackay Medical College, New Taipei 25245, Taiwan.
Ho CS; Department of Pediatric Neurology, Mackay Memorial Hospital, Taipei 10449, Taiwan.
Huang YW; Department of Medical Research, Mackay Memorial Hospital, Taipei 10449, Taiwan.
Wu TY; Department of Medical Research, Mackay Memorial Hospital, Taipei 10449, Taiwan.
Lee TH; Department of Medical Research, Mackay Memorial Hospital, Taipei 10449, Taiwan.
Huang ZD; Department of Medical Research, Mackay Memorial Hospital, Taipei 10449, Taiwan.
Wang TJ; Department of Laboratory Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan.
Yang SJ; Department of Medical Research, Mackay Memorial Hospital, Taipei 10449, Taiwan.
Chiang MF; Department of Neurosurgery, Mackay Memorial Hospital, Taipei 10449, Taiwan.; Mackay Medicine, Nursing and Management College, Taipei 11260, Taiwan.; Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei 11031, Taiwan.; Pokaż więcej
Źródło:: Cells [Cells] 2020 May 01; Vol. 9 (5). Date of Electronic Publication: 2020 May 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Autophagy*
Leukodystrophy, Globoid Cell/*pathology
Proteasome Endopeptidase Complex/*metabolism
Animals ; Autophagosomes/drug effects ; Autophagosomes/metabolism ; Brain/metabolism ; Brain/pathology ; Cell Line ; Cell Respiration/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Humans ; Lysosomes/drug effects ; Lysosomes/metabolism ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Mitochondria/metabolism ; Nerve Degeneration/pathology ; Neurons/drug effects ; Neurons/metabolism ; Oligodendroglia/drug effects ; Oligodendroglia/metabolism ; Protein Aggregates/drug effects ; Psychosine/pharmacology ; Reactive Oxygen Species/metabolism ; Sequestosome-1 Protein/metabolism ; Time Factors ; Ubiquitin/metabolism ; White Matter/pathology

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Skocz do pozycji: 16.

Tytuł:: Autophagy Modulation as a Treatment of Amyloid Diseases.
Autorzy:: Mputhia Z; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Nedlands, WA 6009, Australia. .
Hone E; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Nedlands, WA 6009, Australia. .
Tripathi T; Department of Biochemistry, North-Eastern Hill University, Meghalaya 793022, India. .
Sargeant T; Hopwood Centre for Neurobiology, SAHMRI, Adelaide, SA 5000, Australia. .
Martins R; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Nedlands, WA 6009, Australia. .; School of Biomedical Science, Macquarie University, Sydney, NSW 2109, Australia. .
Bharadwaj P; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Nedlands, WA 6009, Australia. .; School of Pharmacy and Biomedical Sciences, Curtin Health and Innovation Research Institute (CHIRI), Faculty of Health Sciences, Curtin University, Bentley, WA 6102, Australia. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2019 Sep 16; Vol. 24 (18). Date of Electronic Publication: 2019 Sep 16.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Amyloidogenic Proteins/*chemistry
Autophagy/*drug effects
Amyloid/chemistry ; Amyloid/metabolism ; Amyloidogenic Proteins/antagonists & inhibitors ; Amyloidogenic Proteins/metabolism ; Animals ; Apoptosis ; Biomarkers ; Disease Susceptibility ; Humans ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/metabolism ; Protein Aggregates ; Protein Aggregation, Pathological/drug therapy ; Signal Transduction

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Skocz do pozycji: 17.

Tytuł:: A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation.
Autorzy:: Cui Y; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA.
Parashar S; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA.
Zahoor M; Institute of Basic Medical Sciences, Department of Molecular Medicine, University of Oslo, Sognsvannsveien 9, 0372 Oslo, Norway.
Needham PG; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Mari M; Department of Biomedical Sciences of Cells and Systems, University of Groningen Medical Center, Groningen, Netherlands.
Zhu M; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA.
Chen S; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA.
Ho HC; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA.
Reggiori F; Department of Biomedical Sciences of Cells and Systems, University of Groningen Medical Center, Groningen, Netherlands.
Farhan H; Institute of Basic Medical Sciences, Department of Molecular Medicine, University of Oslo, Sognsvannsveien 9, 0372 Oslo, Norway.
Brodsky JL; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Ferro-Novick S; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA. .; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2019 Jul 05; Vol. 365 (6448), pp. 53-60.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Autophagy*
Proteolysis*
COP-Coated Vesicles/*metabolism
Endoplasmic Reticulum/*metabolism
GTPase-Activating Proteins/*metabolism
Membrane Proteins/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Autophagy-Related Proteins/metabolism ; Endoplasmic Reticulum Stress ; Protein Aggregates ; Protein Aggregation, Pathological/metabolism ; Receptors, Cytoplasmic and Nuclear/metabolism ; Unfolded Protein Response

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Skocz do pozycji: 18.

Tytuł:: CD47 deficiency protects cardiomyocytes against hypoxia/reoxygenation injury by rescuing autophagic clearance.
Autorzy:: Li Y; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Zhao K; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Zong P; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Fu H; Key Laboratory of The Model Animal Research, Animal Core Facility of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Zheng Y; Key Laboratory of The Model Animal Research, Animal Core Facility of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Bao D; Key Laboratory of The Model Animal Research, Animal Core Facility of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Yin Y; Key Laboratory of The Model Animal Research, Animal Core Facility of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Chen Q; Key Laboratory of The Model Animal Research, Animal Core Facility of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Lu L; Key Laboratory of The Model Animal Research, Animal Core Facility of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Dai Y; Key Laboratory of The Model Animal Research, Animal Core Facility of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Hou D; Key Laboratory of The Model Animal Research, Animal Core Facility of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Kong X; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2019 Jun; Vol. 19 (6), pp. 5453-5463. Date of Electronic Publication: 2019 Apr 25.
Typ publikacji:: Journal Article
MeSH Terms:: Autophagy*
Cell Hypoxia*
CD47 Antigen/*genetics
Oxygen/*metabolism
Animals ; Apoptosis ; Autophagosomes/metabolism ; Beclin-1/metabolism ; CD47 Antigen/antagonists & inhibitors ; CD47 Antigen/metabolism ; Caspase 3/metabolism ; Cell Line ; Microtubule-Associated Proteins/metabolism ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/metabolism ; Oxidative Stress ; Protein Aggregates/physiology ; RNA Interference ; RNA, Small Interfering/metabolism ; Rats ; Reactive Oxygen Species/metabolism

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Skocz do pozycji: 19.

Tytuł:: Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo.
Autorzy:: Christ MG; Institute of Pathobiochemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, Germany. .
Huesmann H; Institute of Pathobiochemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, Germany. .
Nagel H; Institute of Pathobiochemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, Germany. .
Kern A; Institute of Pathobiochemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, Germany. .
Behl C; Institute of Pathobiochemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, Germany. .; Pokaż więcej
Źródło:: Cells [Cells] 2019 Mar 02; Vol. 8 (3). Date of Electronic Publication: 2019 Mar 02.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Autophagy*/drug effects
Proteostasis*/drug effects
Receptors, sigma/*metabolism
Animals ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/metabolism ; Furans/pharmacology ; HEK293 Cells ; HeLa Cells ; Humans ; Paralysis/pathology ; Phosphorylation/drug effects ; Protein Aggregates/drug effects ; Receptors, sigma/agonists ; Sigma-1 Receptor

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Skocz do pozycji: 20.

Tytuł:: Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity.
Autorzy:: Thellung S; Sezione di Farmacologia, Dipartimento di Medicina Interna & Centro di Eccellenza per la Ricerca Biomedica (CEBR), Università di Genova, 16132 Genova, Italy. .
Corsaro A; Sezione di Farmacologia, Dipartimento di Medicina Interna & Centro di Eccellenza per la Ricerca Biomedica (CEBR), Università di Genova, 16132 Genova, Italy. .
Nizzari M; Sezione di Farmacologia, Dipartimento di Medicina Interna & Centro di Eccellenza per la Ricerca Biomedica (CEBR), Università di Genova, 16132 Genova, Italy. .
Barbieri F; Sezione di Farmacologia, Dipartimento di Medicina Interna & Centro di Eccellenza per la Ricerca Biomedica (CEBR), Università di Genova, 16132 Genova, Italy. .
Florio T; Sezione di Farmacologia, Dipartimento di Medicina Interna & Centro di Eccellenza per la Ricerca Biomedica (CEBR), Università di Genova, 16132 Genova, Italy. .; IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2019 Feb 19; Vol. 20 (4). Date of Electronic Publication: 2019 Feb 19.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Drug Discovery*/methods
Autophagy/*drug effects
Neuroprotection/*drug effects
Animals ; Autophagy/genetics ; Biomarkers ; Humans ; Lysosomes/drug effects ; Lysosomes/genetics ; Lysosomes/metabolism ; Mitochondria/drug effects ; Mitochondria/genetics ; Mitochondria/metabolism ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Protein Aggregates ; Protein Aggregation, Pathological ; Protein Binding ; Protein Conformation ; Protein Folding ; Protein Multimerization ; Proteostasis Deficiencies/drug therapy ; Proteostasis Deficiencies/etiology ; Proteostasis Deficiencies/metabolism ; Proteostasis Deficiencies/pathology ; Structure-Activity Relationship

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