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Wyszukujesz frazę ""Protein Binding"" wg kryterium: Temat


Tytuł:
JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles.
Autorzy:
Rauluseviciute I; Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway.
Riudavets-Puig R; Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway.
Blanc-Mathieu R; Laboratoire Physiologie Cellulaire et Végétale, Univ. Grenoble Alpes, CNRS, CEA, INRAE, IRIG-DBSCI-LPCV, 17 avenue des martyrs, F-38054, Grenoble, France.
Castro-Mondragon JA; Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway.
Ferenc K; Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway.
Kumar V; Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway.
Lemma RB; Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway.
Lucas J; Laboratoire Physiologie Cellulaire et Végétale, Univ. Grenoble Alpes, CNRS, CEA, INRAE, IRIG-DBSCI-LPCV, 17 avenue des martyrs, F-38054, Grenoble, France.
Chèneby J; Center for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway.
Baranasic D; MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.; Division of Electronics, Ruđer Bošković Institute, Bijenička cesta, 10000 Zagreb, Croatia.
Khan A; Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway.; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Fornes O; Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, BC Children's Hospital Research Institute, University of British Columbia, 950 W 28th Ave, Vancouver, BC V5Z 4H4, Canada.
Gundersen S; Center for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway.
Johansen M; Center for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway.
Hovig E; Center for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway.; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway.
Lenhard B; MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
Sandelin A; Department of Biology and Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, DK2200 Copenhagen N, Denmark.
Wasserman WW; Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, BC Children's Hospital Research Institute, University of British Columbia, 950 W 28th Ave, Vancouver, BC V5Z 4H4, Canada.
Parcy F; Laboratoire Physiologie Cellulaire et Végétale, Univ. Grenoble Alpes, CNRS, CEA, INRAE, IRIG-DBSCI-LPCV, 17 avenue des martyrs, F-38054, Grenoble, France.
Mathelier A; Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway.; Center for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway.; Department of Medical Genetics, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2024 Jan 05; Vol. 52 (D1), pp. D174-D182.
Typ publikacji:
Journal Article
MeSH Terms:
Databases, Genetic*/standards
Databases, Genetic*/trends
Protein Binding*
Transcription Factors*/genetics
Transcription Factors*/metabolism
Animals ; Humans ; Mice ; Plants/genetics
Czasopismo naukowe
Tytuł:
Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
Autorzy:
Du Y; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA; Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Bradshaw WJ; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, University of Oxford, Oxford, UK.
Leisner TM; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chapel Hill, North Carolina, USA.
Annor-Gyamfi JK; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, Structural Genomics Consortium, Chapel Hill, North Carolina, USA.
Qian K; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA; Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Bashore FM; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, Structural Genomics Consortium, Chapel Hill, North Carolina, USA.
Sikdar A; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chapel Hill, North Carolina, USA.
Nwogbo FO; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chapel Hill, North Carolina, USA.
Ivanov AA; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA; Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Frye SV; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chapel Hill, North Carolina, USA.
Gileadi O; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, University of Oxford, Oxford, UK.
Brennan PE; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, University of Oxford, Oxford, UK.
Levey AI; Department of Neurology, Emory Goizueta Alzheimer's Disease Research Center, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia, USA.
Axtman AD; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, Structural Genomics Consortium, Chapel Hill, North Carolina, USA. Electronic address: .
Pearce KH; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chapel Hill, North Carolina, USA. Electronic address: .
Fu H; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA; Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address: .
Katis VL; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, University of Oxford, Oxford, UK. Electronic address: .
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Corporate Authors:
Emory-Sage-SGC TREAT-AD Center
Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Dec; Vol. 299 (12), pp. 105382. Date of Electronic Publication: 2023 Oct 21.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Alzheimer Disease*/pathology
Protein Binding*/drug effects
Humans ; FERM Domains ; Hyaluronan Receptors/metabolism ; Proteomics
Czasopismo naukowe
Tytuł:
Gluing the pieces together.
Autorzy:
Kozicka Z; Dana-Farber Cancer Institute, Boston, MA, USA.; Friedrich Miescher Institute for Biomedical Research, University of Basel, Basel, Switzerland.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Nov 17; Vol. 382 (6672), pp. 779-780. Date of Electronic Publication: 2023 Nov 16.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Design*
Protein Binding*/drug effects
Proteolysis*/drug effects
Humans ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Deriving protein binding-corrected chemical concentrations for in vitro testing.
Autorzy:
Kolli AR; PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2023 Nov; Vol. 16 (11), pp. 2123-2129. Date of Electronic Publication: 2023 Aug 28.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Binding*
Humans ; In Vitro Techniques
Czasopismo naukowe
Tytuł:
DeepPRObind: Modular Deep Learner that Accurately Predicts Structure and Disorder-Annotated Protein Binding Residues.
Autorzy:
Zhang F; Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha 410083, China.
Li M; Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha 410083, China. Electronic address: .
Zhang J; School of Computer and Information Technology, Xinyang Normal University, Xinyang 464000, China.
Shi W; Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha 410083, China.
Kurgan L; Department of Computer Science, Virginia Commonwealth University, Richmond, VA 23284, USA. Electronic address: .
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Źródło:
Journal of molecular biology [J Mol Biol] 2023 Jul 15; Vol. 435 (14), pp. 167945. Date of Electronic Publication: 2023 Jan 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amino Acids*
Computational Biology*/methods
Protein Binding*
Deep Learning*
Databases, Protein ; Proteome/chemistry ; Protein Conformation
Czasopismo naukowe
Tytuł:
LigBind: Identifying Binding Residues for Over 1000 Ligands with Relation-Aware Graph Neural Networks.
Autorzy:
Xia Y; Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, and Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai 200240, China.
Pan X; Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, and Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai 200240, China. Electronic address: .
Shen HB; Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, and Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai 200240, China. Electronic address: .
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Źródło:
Journal of molecular biology [J Mol Biol] 2023 Jul 01; Vol. 435 (13), pp. 168091. Date of Electronic Publication: 2023 Apr 12.
Typ publikacji:
Dataset; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Binding*
Humans ; Binding Sites ; Ligands ; Neural Networks, Computer ; SARS-CoV-2 ; Viral Proteins
Czasopismo naukowe
Tytuł:
Plasma Protein Binding Evaluations of Per- and Polyfluoroalkyl Substances for Category-Based Toxicokinetic Assessment.
Autorzy:
Smeltz M; Center for Computational Toxicology and Exposure, US EPA Office of Research and Development, Research Triangle Park, North Carolina 27711, United States.
Wambaugh JF; Center for Computational Toxicology and Exposure, US EPA Office of Research and Development, Research Triangle Park, North Carolina 27711, United States.
Wetmore BA; Center for Computational Toxicology and Exposure, US EPA Office of Research and Development, Research Triangle Park, North Carolina 27711, United States.
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Źródło:
Chemical research in toxicology [Chem Res Toxicol] 2023 Jun 19; Vol. 36 (6), pp. 870-881. Date of Electronic Publication: 2023 May 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Fluorocarbons*/chemistry
Protein Binding*/drug effects
Toxicokinetics*
Water Pollutants, Chemical*/analysis
Humans ; Bayes Theorem ; Blood Proteins ; Carboxylic Acids/toxicity ; Carboxylic Acids/analysis
Czasopismo naukowe
Tytuł:
De novo design of protein interactions with learned surface fingerprints.
Autorzy:
Gainza P; Laboratory of Protein Design and Immunoengineering, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Monte Rosa Therapeutics, Basel, Switzerland.
Wehrle S; Laboratory of Protein Design and Immunoengineering, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Van Hall-Beauvais A; Laboratory of Protein Design and Immunoengineering, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Marchand A; Laboratory of Protein Design and Immunoengineering, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Scheck A; Laboratory of Protein Design and Immunoengineering, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Harteveld Z; Laboratory of Protein Design and Immunoengineering, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Buckley S; Laboratory of Protein Design and Immunoengineering, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Ni D; Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Tan S; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Sverrisson F; Laboratory of Protein Design and Immunoengineering, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Goverde C; Laboratory of Protein Design and Immunoengineering, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Turelli P; Laboratory of Virology and Genetics, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Raclot C; Laboratory of Virology and Genetics, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Teslenko A; Laboratory of Biophysical Chemistry of Macromolecules, School of Basic Sciences, Institute of Chemical Sciences and Engineering (ISIC), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Pacesa M; Laboratory of Protein Design and Immunoengineering, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Rosset S; Laboratory of Protein Design and Immunoengineering, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Georgeon S; Laboratory of Protein Design and Immunoengineering, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Marsden J; Laboratory of Protein Design and Immunoengineering, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Petruzzella A; Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Liu K; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Xu Z; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Chai Y; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Han P; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Gao GF; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Oricchio E; Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Fierz B; Laboratory of Biophysical Chemistry of Macromolecules, School of Basic Sciences, Institute of Chemical Sciences and Engineering (ISIC), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Trono D; Laboratory of Virology and Genetics, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Stahlberg H; Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Bronstein M; Department of Computer Science, University of Oxford, Oxford, UK. .
Correia BE; Laboratory of Protein Design and Immunoengineering, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. .; Swiss Institute of Bioinformatics, Lausanne, Switzerland. .
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Źródło:
Nature [Nature] 2023 May; Vol. 617 (7959), pp. 176-184. Date of Electronic Publication: 2023 Apr 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Proteins*/chemistry
Proteins*/metabolism
Protein Binding*
Deep Learning*
Computer Simulation*
Humans ; Proteomics ; Protein Interaction Maps ; Binding Sites ; Synthetic Biology
Czasopismo naukowe
Tytuł:
Oxidation-Induced Protein Cross-Linking in Mammalian Cells.
Autorzy:
Li H; State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Nanjing 210023, Jiangsu, China.
Lv L; Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing 210009, Jiangsu, China.
Tang S; State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Nanjing 210023, Jiangsu, China.
Zang Y; State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Nanjing 210023, Jiangsu, China.
Wan T; State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Nanjing 210023, Jiangsu, China.
Wang D; Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing 210009, Jiangsu, China.
Cai L; Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Jiangsu Province Key Laboratory of Green Biomass Based Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, Jiangsu, China.
Ye H; Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing 210009, Jiangsu, China.
Tan R; State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Nanjing 210023, Jiangsu, China.; State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210023, Jiangsu, China.
Wang N; State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Nanjing 210023, Jiangsu, China.
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Źródło:
ACS synthetic biology [ACS Synth Biol] 2023 Apr 21; Vol. 12 (4), pp. 984-992. Date of Electronic Publication: 2023 Mar 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Proteins*/drug effects
Proteins*/genetics
Proteins*/metabolism
Protein Binding*
Animals ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Genetic Code ; Mammals/genetics ; Sulfides/metabolism ; Oxidation-Reduction ; Cross-Linking Reagents/pharmacology ; Oxidants/pharmacology
Czasopismo naukowe
Tytuł:
A significance score for protein-protein interaction models through random docking.
Autorzy:
McCoy KM; Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, USA.
Ackerman ME; Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, USA.; Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Grigoryan G; Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, USA.; Department of Computer Science, Dartmouth College, Hanover, New Hampshire, USA.
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Źródło:
Protein science : a publication of the Protein Society [Protein Sci] 2024 Feb; Vol. 33 (2), pp. e4853.
Typ publikacji:
Journal Article
MeSH Terms:
Proteins*/chemistry
Protein Interaction Mapping*/methods
Molecular Docking Simulation ; Protein Conformation ; Protein Binding ; Software ; Algorithms ; Computational Biology/methods ; Binding Sites
Czasopismo naukowe
Tytuł:
Interaction mechanism of a cysteine protease inhibitor, odanacatib, with human serum albumin: In vitro and bioinformatics studies.
Autorzy:
Asngari NJM; Department of Oral & Craniofacial Sciences, Faculty of Dentistry, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Bakar KA; Department of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.
Feroz SR; Department of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.
Razak FA; Department of Oral & Craniofacial Sciences, Faculty of Dentistry, Universiti Malaya, 50603 Kuala Lumpur, Malaysia; Adjunct Professor, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia.
Halim AAA; Department of Oral & Craniofacial Sciences, Faculty of Dentistry, Universiti Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: .
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Źródło:
Biophysical chemistry [Biophys Chem] 2024 Feb; Vol. 305, pp. 107140. Date of Electronic Publication: 2023 Nov 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Serum Albumin, Human*/chemistry
Cysteine Proteinase Inhibitors*/pharmacology
Humans ; Molecular Docking Simulation ; Binding Sites ; Protein Binding ; Spectrometry, Fluorescence ; Circular Dichroism ; Thermodynamics
Czasopismo naukowe
Tytuł:
Identification of DNA-protein binding residues through integration of Transformer encoder and Bi-directional Long Short-Term Memory.
Autorzy:
Zhao H; School of Electronic and Information Engineering, Suzhou University of Science and Technology, Suzhou, China.
Zhu B; School of Electronic and Information Engineering, Suzhou University of Science and Technology, Suzhou, China.
Jiang T; Gusu School, Nanjing Medical University, Suzhou, China.
Cui Z; School of Electronic and Information Engineering, Suzhou University of Science and Technology, Suzhou, China.
Wu H; School of Electronic and Information Engineering, Suzhou University of Science and Technology, Suzhou, China.
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Źródło:
Mathematical biosciences and engineering : MBE [Math Biosci Eng] 2024 Jan; Vol. 21 (1), pp. 170-185. Date of Electronic Publication: 2022 Dec 11.
Typ publikacji:
Journal Article
MeSH Terms:
Memory, Short-Term*
Proteins*/chemistry
Protein Binding ; Binding Sites ; DNA/chemistry
Czasopismo naukowe
Tytuł:
In vitro biodistribution studies on clinically approved FGFR inhibitors ponatinib, nintedanib, erlotinib and the investigational inhibitor KP2692.
Autorzy:
Dömötör O; Department of Molecular and Analytical Chemistry, University of Szeged, Dóm tér 7-8, 6720 Szeged, Hungary. Electronic address: .
Mathuber M; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 42, 1090 Vienna, Austria.
Kowol CR; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 42, 1090 Vienna, Austria; Research Cluster 'Translational Cancer Therapy Research', University of Vienna and Medical University of Vienna, Vienna, Austria.
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Źródło:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2024 Jan 01; Vol. 192, pp. 106651. Date of Electronic Publication: 2023 Nov 25.
Typ publikacji:
Journal Article
MeSH Terms:
Imidazoles*/pharmacology
Serum Albumin, Human*
Humans ; Erlotinib Hydrochloride/pharmacology ; Tissue Distribution ; Protein Binding
Czasopismo naukowe
Tytuł:
Do the enantiomers of ketamine bind enantioselectively to human serum albumin?
Autorzy:
Schmidt S; Institute for Pharmacy and Food Chemistry, Am Hubland, D-97074 Wuerzburg, Germany.
Holzgrabe U; Institute for Pharmacy and Food Chemistry, Am Hubland, D-97074 Wuerzburg, Germany. Electronic address: .
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Źródło:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2024 Jan 01; Vol. 192, pp. 106640. Date of Electronic Publication: 2023 Nov 18.
Typ publikacji:
Journal Article
MeSH Terms:
Serum Albumin, Human*/chemistry
Ketamine*
Humans ; Serum Albumin/metabolism ; Stereoisomerism ; Protein Binding
Czasopismo naukowe
Tytuł:
Steric hindrance and charge influence on the cytotoxic activity and protein binding properties of diruthenium complexes.
Autorzy:
Terán A; MatMoPol Research Group, Department of Inorganic Chemistry, Faculty of Chemical Sciences, Complutense University of Madrid, Avda. Complutense s/n, 28040 Madrid, Spain.
Ferraro G; Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via Cinthia 21, 80126 Naples, Italy.
Imbimbo P; Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via Cinthia 21, 80126 Naples, Italy.
Sánchez-Peláez AE; MatMoPol Research Group, Department of Inorganic Chemistry, Faculty of Chemical Sciences, Complutense University of Madrid, Avda. Complutense s/n, 28040 Madrid, Spain.
Monti DM; Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via Cinthia 21, 80126 Naples, Italy.
Herrero S; MatMoPol Research Group, Department of Inorganic Chemistry, Faculty of Chemical Sciences, Complutense University of Madrid, Avda. Complutense s/n, 28040 Madrid, Spain. Electronic address: .
Merlino A; Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via Cinthia 21, 80126 Naples, Italy. Electronic address: .
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Źródło:
International journal of biological macromolecules [Int J Biol Macromol] 2023 Dec 31; Vol. 253 (Pt 1), pp. 126666. Date of Electronic Publication: 2023 Sep 01.
Typ publikacji:
Journal Article
MeSH Terms:
Metals*
Humans ; Protein Binding
Czasopismo naukowe
Tytuł:
Protein binding investigation of first-line and second-line antituberculosis drugs.
Autorzy:
Fage D; Department of Clinical Chemistry, Laboratoire Hospitalier Universitaire de Bruxelles - Universitair Laboratorium Brussel, Brussels, Belgium. Electronic address: .
Aalhoul F; Haute Ecole Lucia de Brouckère, Brussels, Belgium.
Cotton F; Department of Clinical Chemistry, Laboratoire Hospitalier Universitaire de Bruxelles - Universitair Laboratorium Brussel, Brussels, Belgium.
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Źródło:
International journal of antimicrobial agents [Int J Antimicrob Agents] 2023 Dec; Vol. 62 (6), pp. 106999. Date of Electronic Publication: 2023 Oct 13.
Typ publikacji:
Journal Article
MeSH Terms:
Antitubercular Agents*/pharmacology
Antitubercular Agents*/therapeutic use
Tuberculosis*/drug therapy
Humans ; Isoniazid/pharmacology ; Linezolid ; Rifampin ; Ethambutol/pharmacology ; Pyrazinamide/pharmacology ; Levofloxacin ; Moxifloxacin ; Protein Binding
Czasopismo naukowe
Tytuł:
Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increased Mitochondrial Fission In Vitro and Atherosclerosis in High-Fat-Diet-Fed ApoE -/- Mice.
Autorzy:
Ren, Jinyi (AUTHOR)
Liu, Jiaqing (AUTHOR)
Zhang, Jiahui (AUTHOR)
Hu, Xinxin (AUTHOR)
Cui, Ying (AUTHOR)
Wei, Xiaoqing (AUTHOR)
Ma, Yang (AUTHOR)
Li, Xia (AUTHOR)
Zhao, Ying (AUTHOR)
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Źródło:
International Journal of Molecular Sciences. Jan2024, Vol. 25 Issue 1, p244. 17p.
Czasopismo naukowe
Tytuł:
Unraveling the Interplay of Extracellular Domain Conformational Changes and Parathyroid Hormone Type 1 Receptor Activation in Class B1 G Protein-Coupled Receptors: Integrating Enhanced Sampling Molecular Dynamics Simulations and Markov State Models.
Autorzy:
Li M; School of Physics and Astronomy & Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.; College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.
Zhang X; College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.
Li S; Centre in Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao 999078, China.
Guo J; Centre in Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao 999078, China.; Engineering Research Centre of Applied Technology on Machine Translation and Artificial Intelligence, Macao Polytechnic University, Macao 999078, China.
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Źródło:
ACS chemical neuroscience [ACS Chem Neurosci] 2024 Feb 21; Vol. 15 (4), pp. 844-853. Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Dynamics Simulation*
Signal Transduction*
Receptor, Parathyroid Hormone, Type 1/chemistry ; Receptor, Parathyroid Hormone, Type 1/metabolism ; Amino Acid Sequence ; Protein Binding ; Receptors, G-Protein-Coupled/metabolism ; Parathyroid Hormone/chemistry ; Parathyroid Hormone/metabolism
Czasopismo naukowe
Tytuł:
Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct.
Autorzy:
Zehe M; University of Würzburg, Institute of Pharmacy and Food Chemistry, Am Hubland, DE-97074 Würzburg, Germany.
Kehrein J; University of Würzburg, Institute of Pharmacy and Food Chemistry, Am Hubland, DE-97074 Würzburg, Germany.
Schollmayer C; University of Würzburg, Institute of Pharmacy and Food Chemistry, Am Hubland, DE-97074 Würzburg, Germany.
Plank C; University of Würzburg, Institute of Pharmacy and Food Chemistry, Am Hubland, DE-97074 Würzburg, Germany.; University of Würzburg, Department of Biochemistry and Cancer Therapy Research Center (CTRC), Theodor-Boveri-Institute, Am Hubland, DE-97074 Würzburg, Germany.
Kovacs H; Bruker Switzerland AG, Industriestrasse 26, CH-8117 Fällanden, Switzerland.
Merino Asumendi E; University of Würzburg, Institute of Pharmacy and Food Chemistry, Am Hubland, DE-97074 Würzburg, Germany.
Holzgrabe U; University of Würzburg, Institute of Pharmacy and Food Chemistry, Am Hubland, DE-97074 Würzburg, Germany.
Grimm C; University of Würzburg, Department of Biochemistry and Cancer Therapy Research Center (CTRC), Theodor-Boveri-Institute, Am Hubland, DE-97074 Würzburg, Germany.
Sotriffer C; University of Würzburg, Institute of Pharmacy and Food Chemistry, Am Hubland, DE-97074 Würzburg, Germany.
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Źródło:
ACS chemical biology [ACS Chem Biol] 2024 Feb 16; Vol. 19 (2), pp. 392-406. Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
HSP70 Heat-Shock Proteins*/metabolism
Molecular Dynamics Simulation*
Protein Domains ; Magnetic Resonance Spectroscopy ; Nucleotides/metabolism ; Protein Binding ; HSP90 Heat-Shock Proteins/metabolism
Czasopismo naukowe

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