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Wyszukujesz frazę ""Protein Biosynthesis"" wg kryterium: Temat


Starter badań:

Tytuł :
Translational and post-translational regulation of polyamine metabolic enzymes in plants.
Autorzy :
Jiménez-Bremont JF; Laboratorio de Biotecnología Molecular Plantas, División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica AC, San Luis Potosí, Mexico. Electronic address: .
Chávez-Martínez AI; Laboratorio de Biotecnología Molecular Plantas, División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica AC, San Luis Potosí, Mexico.
Ortega-Amaro MA; Laboratorio de Biotecnología Molecular Plantas, División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica AC, San Luis Potosí, Mexico.
Guerrero-González ML; Facultad de Agronomía y Veterinaria, Universidad Autónoma de San Luis Potosí (UASLP), San Luis Potosí, Mexico.
Jasso-Robles FI; Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí (UASLP), San Luis Potosí, Mexico.
Maruri-López I; Biological and Environmental Science and Engineering Division, Center for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Liu JH; Key Laboratory of Horticultural Plant Biology, College of Horticulture and Forestry Science, Huazhong Agricultural University, Wuhan, China.
Gill SS; Stress Physiology & Molecular Biology Lab, Centre for Biotechnology, Maharshi Dayanand University, Rohtak 124001, Haryana, India.
Rodríguez-Kessler M; Facultad de Ciencias, Universidad Autónoma de San Luis Potosí (UASLP), San Luis Potosí, Mexico. Electronic address: .
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Źródło :
Journal of biotechnology [J Biotechnol] 2022 Jan 20; Vol. 344, pp. 1-10. Date of Electronic Publication: 2021 Dec 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Polyamines*
Protein Biosynthesis*
Open Reading Frames ; Plants/genetics ; RNA, Messenger
Czasopismo naukowe
Tytuł :
Machine Learning for Designing Next-Generation mRNA Therapeutics.
Autorzy :
Castillo-Hair SM; Department of Electrical & Computer Engineering, University of Washington, Seattle, Washington 98195, United States.; eScience Institute, University of Washington, Seattle, Washington 98195, United States.
Seelig G; Department of Electrical & Computer Engineering, University of Washington, Seattle, Washington 98195, United States.; Paul G. Allen School of Computer Science & Engineering, University of Washington, Seattle, Washington 98195, United States.
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Źródło :
Accounts of chemical research [Acc Chem Res] 2022 Jan 04; Vol. 55 (1), pp. 24-34. Date of Electronic Publication: 2021 Dec 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
COVID-19*
Protein Biosynthesis*
COVID-19 Vaccines ; Humans ; Machine Learning ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Analysis of mRNA Translation by Polysome Profiling.
Autorzy :
Cammas A; Cancer Research Center of Toulouse, INSERM UMR 1037, Toulouse, France.; Université Toulouse III Paul Sabatier, Toulouse, France.
Herviou P; Cancer Research Center of Toulouse, INSERM UMR 1037, Toulouse, France.; Université Toulouse III Paul Sabatier, Toulouse, France.
Dumas L; Cancer Research Center of Toulouse, INSERM UMR 1037, Toulouse, France.; Université Toulouse III Paul Sabatier, Toulouse, France.
Millevoi S; Cancer Research Center of Toulouse, INSERM UMR 1037, Toulouse, France. .; Université Toulouse III Paul Sabatier, Toulouse, France. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2404, pp. 69-81.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Biosynthesis*
Gene Expression Profiling ; Polyribosomes/genetics ; Polyribosomes/metabolism ; Proteins/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
Regulation of gene expression via translational buffering.
Autorzy :
Kusnadi EP; Translational Prostate Cancer Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia; Cancer Program, Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Timpone C; Translational Prostate Cancer Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
Topisirovic I; Lady Davis Institute, Gerald Bronfman Department of Oncology and Departments of Biochemistry and Experimental Medicine, McGill University, Montreal, QC, Canada. Electronic address: .
Larsson O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden. Electronic address: .
Furic L; Translational Prostate Cancer Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia; Cancer Program, Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2022 Jan; Vol. 1869 (1), pp. 119140. Date of Electronic Publication: 2021 Sep 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Homeostasis*
Protein Biosynthesis*
Animals ; Codon Usage ; Humans ; RNA Processing, Post-Transcriptional ; Ribosomal Proteins/metabolism
Czasopismo naukowe
Tytuł :
Dysfunctional mitochondrial translation and combined oxidative phosphorylation deficiency in a mouse model of hepatoencephalopathy due to Gfm1 mutations.
Autorzy :
Molina-Berenguer M; Research Group on Neuromuscular and Mitochondrial Diseases, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.; Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.
Vila-Julià F; Research Group on Neuromuscular and Mitochondrial Diseases, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.; Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.
Pérez-Ramos S; Research Group on Neuromuscular and Mitochondrial Diseases, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.; Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.
Salcedo-Allende MT; Pathology Department, Vall d'Hebron Research Institute, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Cámara Y; Research Group on Neuromuscular and Mitochondrial Diseases, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.; Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.
Torres-Torronteras J; Research Group on Neuromuscular and Mitochondrial Diseases, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.; Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.
Martí R; Research Group on Neuromuscular and Mitochondrial Diseases, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.; Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2022 Jan; Vol. 36 (1), pp. e22091.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation, Missense*
Oxidative Phosphorylation*
Protein Biosynthesis*
Hepatic Encephalopathy/*metabolism
Metabolism, Inborn Errors/*metabolism
Mitochondria, Liver/*metabolism
Mitochondrial Proteins/*metabolism
Peptide Elongation Factor G/*metabolism
Amino Acid Substitution ; Animals ; Disease Models, Animal ; Electron Transport Complex IV/genetics ; Electron Transport Complex IV/metabolism ; Hepatic Encephalopathy/genetics ; Metabolism, Inborn Errors/genetics ; Mice ; Mice, Knockout ; Mitochondria, Liver/genetics ; Mitochondrial Proteins/genetics ; Peptide Elongation Factor G/genetics
SCR Disease Name :
Combined Oxidative Phosphorylation Deficiency 1
Czasopismo naukowe
Tytuł :
Combinations of slow-translating codon clusters can increase mRNA half-life in Saccharomyces cerevisiae .
Autorzy :
Sharma AK; Department of Physics, Indian Institute of Technology, Jammu 181 221, India; .; Department of Chemistry, Pennsylvania State University, University Park, PA 16802.
Venezian J; Faculty of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Shiber A; Faculty of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel; .
Kramer G; Center for Molecular Biology of the University of Heidelberg, Heidelberg D-69120, Germany.; German Cancer Research Center 69120 Heidelberg, Germany.
Bukau B; Center for Molecular Biology of the University of Heidelberg, Heidelberg D-69120, Germany.; German Cancer Research Center 69120 Heidelberg, Germany.
O'Brien EP; Department of Chemistry, Pennsylvania State University, University Park, PA 16802; .; Bioinformatics and Genomics Graduate Program, The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Dec 21; Vol. 118 (51).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Protein Biosynthesis*
RNA, Messenger/*metabolism
Saccharomyces cerevisiae/*metabolism
Fungal Proteins/biosynthesis ; Half-Life ; Models, Genetic
Czasopismo naukowe
Tytuł :
hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen-Glucose Deprivation in Hippocampal Neurons.
Autorzy :
Kim SW; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.
Hong IK; College of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea.
Kim M; College of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea.
Song YS; College of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea.
Kim KT; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.
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Źródło :
Cells [Cells] 2021 Dec 17; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Actin Depolymerizing Factors/*metabolism
Glucose/*deficiency
Heterogeneous Nuclear Ribonucleoprotein A1/*metabolism
Heterogeneous-Nuclear Ribonucleoproteins/*metabolism
Hippocampus/*pathology
Neurons/*metabolism
Oxygen/*metabolism
Actin Depolymerizing Factors/genetics ; Animals ; Brain Ischemia/pathology ; Cells, Cultured ; Disease Models, Animal ; Mice ; Protein Binding ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
Phosphorylation of ribosomal protein S6 differentially affects mRNA translation based on ORF length.
Autorzy :
Bohlen J; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; CellNetworks - Cluster of Excellence, Heidelberg University, Heidelberg, Germany.; Heidelberg University, 69120 Heidelberg, Germany.; Heidelberg Biosciences International Graduate School (HBIGS), Germany.; National Center for Tumor Diseases (NCT), partner site.
Roiuk M; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; CellNetworks - Cluster of Excellence, Heidelberg University, Heidelberg, Germany.; Heidelberg University, 69120 Heidelberg, Germany.; National Center for Tumor Diseases (NCT), partner site.
Teleman AA; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; CellNetworks - Cluster of Excellence, Heidelberg University, Heidelberg, Germany.; Heidelberg University, 69120 Heidelberg, Germany.; Heidelberg Biosciences International Graduate School (HBIGS), Germany.; National Center for Tumor Diseases (NCT), partner site.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Dec 16; Vol. 49 (22), pp. 13062-13074.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Open Reading Frames/*genetics
RNA, Messenger/*genetics
Ribosomal Protein S6/*genetics
Animals ; Cells, Cultured ; HeLa Cells ; Humans ; Immunoblotting ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mice ; Mutation ; Phosphorylation ; Protein Processing, Post-Translational ; RNA, Messenger/metabolism ; RNA-Seq/methods ; Ribosomal Protein S6/metabolism ; Ribosomes/genetics ; Ribosomes/metabolism
Czasopismo naukowe
Tytuł :
Double-Stranded RNA Structural Elements Holding the Key to Translational Regulation in Cancer: The Case of Editing in RNA-Binding Motif Protein 8A.
Autorzy :
Abukar A; Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Zürich, 8091 Zürich, Switzerland.
Wipplinger M; Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Zürich, 8091 Zürich, Switzerland.
Hariharan A; Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Zürich, 8091 Zürich, Switzerland.
Sun S; Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Zürich, 8091 Zürich, Switzerland.
Ronner M; Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Zürich, 8091 Zürich, Switzerland.
Sculco M; Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Zürich, 8091 Zürich, Switzerland.
Okonska A; Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Zürich, 8091 Zürich, Switzerland.
Kresoja-Rakic J; Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Zürich, 8091 Zürich, Switzerland.; Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
Rehrauer H; Functional Genomics Center Zürich, Eidgenössische Technische Hochschule Zürich, University of Zürich, 8057 Zürich, Switzerland.
Qi W; Functional Genomics Center Zürich, Eidgenössische Technische Hochschule Zürich, University of Zürich, 8057 Zürich, Switzerland.
Beusechem VWV; Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Felley-Bosco E; Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Zürich, 8091 Zürich, Switzerland.
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Źródło :
Cells [Cells] 2021 Dec 15; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
RNA Editing*
RNA-Binding Motifs*
RNA, Double-Stranded/*chemistry
RNA-Binding Proteins/*metabolism
3' Untranslated Regions/genetics ; Adenosine Deaminase/metabolism ; Animals ; Cell Line, Tumor ; Epithelium/metabolism ; Genes, Reporter ; Humans ; Mesothelioma/genetics ; Mesothelioma/metabolism ; Mesothelioma/pathology ; Mice ; Models, Biological ; Protein Binding
Czasopismo naukowe
Tytuł :
Poly(C)-binding Protein 2 Regulates the p53 Expression via Interactions with the 5'-Terminal Region of p53 mRNA.
Autorzy :
Janecki DM; Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.
Swiatkowska A; Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.
Szpotkowska J; Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.
Urbanowicz A; Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.
Kabacińska M; Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.
Szpotkowski K; Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.
Ciesiołka J; Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 10; Vol. 22 (24). Date of Electronic Publication: 2021 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
5' Untranslated Regions*
Protein Biosynthesis*
RNA Stability*
RNA-Binding Proteins/*metabolism
Tumor Suppressor Protein p53/*metabolism
Down-Regulation ; HCT116 Cells ; Humans ; RNA-Binding Proteins/genetics ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
Therapeutic mRNA Engineering from Head to Tail.
Autorzy :
Jia L; Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, United States.
Qian SB; Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, United States.
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Źródło :
Accounts of chemical research [Acc Chem Res] 2021 Dec 07; Vol. 54 (23), pp. 4272-4282. Date of Electronic Publication: 2021 Nov 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19*
Protein Biosynthesis*/genetics
Humans ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Viral ; SARS-CoV-2 ; mRNA Vaccines
Czasopismo naukowe
Tytuł :
Directed-evolution of translation system for efficient unnatural amino acids incorporation and generalizable synthetic auxotroph construction.
Autorzy :
Zhao H; Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China.; Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
Ding W; Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China.; Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
Zang J; Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China.; Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
Yang Y; School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210046, China.
Liu C; Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China.; Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
Hu L; Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China.; Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
Chen Y; Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China.; Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
Liu G; Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China.; Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
Fang Y; Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China.; Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
Yuan Y; Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Lin S; Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China. .; Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China. .; Cancer Center, Zhejiang University, Hangzhou, 310058, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Dec 02; Vol. 12 (1), pp. 7039. Date of Electronic Publication: 2021 Dec 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Amino Acyl-tRNA Synthetases/*genetics
Directed Molecular Evolution/*methods
Escherichia coli/*genetics
Phenylalanine/*metabolism
RNA, Transfer/*genetics
Amino Acids/metabolism ; Amino Acids/pharmacology ; Amino Acyl-tRNA Synthetases/metabolism ; Animals ; Base Pairing ; Biomimetic Materials/metabolism ; Biomimetic Materials/pharmacology ; Cell Engineering ; Escherichia coli/metabolism ; Gene Expression ; Genes, Reporter ; Germ-Free Life ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Nucleic Acid Conformation ; Phenylalanine/pharmacology ; Plasmids/chemistry ; Plasmids/metabolism ; RNA, Transfer/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
The pioneer round of translation ensures proper targeting of ER and mitochondrial proteins.
Autorzy :
Park J; Creative Research Initiatives Center for Molecular Biology of Translation, Korea University, Seoul 02841, Republic of Korea.; Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea.
Chang J; Creative Research Initiatives Center for Molecular Biology of Translation, Korea University, Seoul 02841, Republic of Korea.; Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea.
Hwang HJ; Creative Research Initiatives Center for Molecular Biology of Translation, Korea University, Seoul 02841, Republic of Korea.; Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea.
Jeong K; Creative Research Initiatives Center for Molecular Biology of Translation, Korea University, Seoul 02841, Republic of Korea.; Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea.
Lee HJ; Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea.
Ha H; Creative Research Initiatives Center for Molecular Biology of Translation, Korea University, Seoul 02841, Republic of Korea.; Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea.
Park Y; Creative Research Initiatives Center for Molecular Biology of Translation, Korea University, Seoul 02841, Republic of Korea.; Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea.
Lim C; School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
Woo JS; Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea.
Kim YK; Creative Research Initiatives Center for Molecular Biology of Translation, Korea University, Seoul 02841, Republic of Korea.; Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Dec 02; Vol. 49 (21), pp. 12517-12534.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Endoplasmic Reticulum/*metabolism
Mitochondrial Proteins/*metabolism
Signal Recognition Particle/*metabolism
HEK293 Cells ; HeLa Cells ; Humans ; Mitochondrial Proteins/genetics ; Models, Genetic ; Nuclear Cap-Binding Protein Complex/genetics ; Nuclear Cap-Binding Protein Complex/metabolism ; Polyribosomes/genetics ; Polyribosomes/metabolism ; Protein Binding ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Ribosomes/genetics ; Ribosomes/metabolism ; Signal Recognition Particle/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Ribosome-associated quality control and CAT tailing.
Autorzy :
Howard CJ; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.
Frost A; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.
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Źródło :
Critical reviews in biochemistry and molecular biology [Crit Rev Biochem Mol Biol] 2021 Dec; Vol. 56 (6), pp. 603-620. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Protein Biosynthesis*
Ribosomes/*metabolism
Animals ; Bacteria/genetics ; Bacteria/metabolism ; Eukaryota/genetics ; Eukaryota/metabolism ; Evolution, Molecular ; Humans
Czasopismo naukowe
Tytuł :
ZNF545 loss promotes ribosome biogenesis and protein translation to initiate colorectal tumorigenesis in mice.
Autorzy :
Wang S; Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
Wong CC; Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
Zhang Y; Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
Huang J; Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
Li C; Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
Zhai J; Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
Wang G; Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
Wei H; Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Zhang X; School of Biomedical Engineering, Health Science Centre, Shenzhen University, Shenzhen, China.
He HH; Department of Medical Biophysics, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Ontario, Canada.
Yu J; Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. .
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Źródło :
Oncogene [Oncogene] 2021 Dec; Vol. 40 (48), pp. 6590-6600. Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Biosynthesis*
Carcinogenesis/*pathology
Colorectal Neoplasms/*pathology
Nuclear Proteins/*physiology
RNA, Ribosomal/*metabolism
Ribosomes/*metabolism
Animals ; Azoxymethane/toxicity ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Cell Communication ; Cell Nucleolus/genetics ; Cell Nucleolus/metabolism ; Cell Proliferation ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; RNA, Ribosomal/genetics
Czasopismo naukowe
Tytuł :
DDX3X and DDX3Y are redundant in protein synthesis.
Autorzy :
Venkataramanan S; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California 94143, USA.
Gadek M; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California 94143, USA.
Calviello L; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California 94143, USA.
Wilkins K; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California 94143, USA.
Floor SN; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California 94143, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California 94143, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2021 Dec; Vol. 27 (12), pp. 1577-1588. Date of Electronic Publication: 2021 Sep 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Colonic Neoplasms/*pathology
DEAD-box RNA Helicases/*metabolism
Minor Histocompatibility Antigens/*metabolism
Amino Acid Sequence ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; DEAD-box RNA Helicases/genetics ; HCT116 Cells ; Humans ; Minor Histocompatibility Antigens/genetics ; Sequence Homology
Czasopismo naukowe
Tytuł :
Reverse-translational identification of a cerebellar satiation network.
Autorzy :
Low AYT; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Goldstein N; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Gaunt JR; LKC School of Medicine, Nanyang Technological University, Singapore, Singapore.
Huang KP; Monell Chemical Senses Center, Philadelphia, PA, USA.
Zainolabidin N; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Yip AKK; LKC School of Medicine, Nanyang Technological University, Singapore, Singapore.
Carty JRE; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Choi JY; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Miller AM; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Ho HST; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Lenherr C; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.; Division of Neuroscience, King's College London, London, UK.
Baltar N; Molecular Neurobiology Laboratory, Salk Institute, San Diego, CA, USA.
Azim E; Molecular Neurobiology Laboratory, Salk Institute, San Diego, CA, USA.
Sessions OM; School of Public Health, National University of Singapore, Singapore, Singapore.
Ch'ng TH; LKC School of Medicine, Nanyang Technological University, Singapore, Singapore.
Bruce AS; Department of Pediatrics, University of Kansas Medical Center, Kansas City, KS, USA.
Martin LE; Department of Population Health, University of Kansas Medical Center, Kansas City, KS, USA.
Halko MA; Schizophrenia and Bipolar Disorder Research Program, McLean Hospital, Belmont, MA, USA.; Harvard Medical School, Boston, MA, USA.
Brady RO Jr; Harvard Medical School, Boston, MA, USA.; Beth Israel Deaconess Medical Center, Boston, MA, USA.
Holsen LM; Harvard Medical School, Boston, MA, USA.; Division of Women's Health, Department of Medicine, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
Alhadeff AL; Monell Chemical Senses Center, Philadelphia, PA, USA.; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA.
Chen AI; Center for Aging Research, Scintillon Institute, San Diego, CA, USA. .
Betley JN; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA. .; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA. .
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Źródło :
Nature [Nature] 2021 Dec; Vol. 600 (7888), pp. 269-273. Date of Electronic Publication: 2021 Nov 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Food*
Protein Biosynthesis*
Reverse Genetics*
Body Weight Maintenance/*genetics
Body Weight Maintenance/*physiology
Cerebellum/*physiology
Satiety Response/*physiology
Adult ; Animals ; Appetite Regulation/genetics ; Appetite Regulation/physiology ; Cerebellar Nuclei/cytology ; Cerebellar Nuclei/physiology ; Cerebellum/cytology ; Cues ; Dopamine/metabolism ; Eating/genetics ; Eating/physiology ; Feeding Behavior/physiology ; Female ; Homeostasis ; Humans ; Magnetic Resonance Imaging ; Male ; Mice ; Mice, Inbred C57BL ; Neostriatum/metabolism ; Neurons/physiology ; Obesity/genetics ; Philosophy ; Young Adult
Czasopismo naukowe
Tytuł :
Chemotherapy agents reduce protein synthesis and ribosomal capacity in myotubes independent of oxidative stress.
Autorzy :
Guo B; Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania.
Bennet D; Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania.
Belcher DJ; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania.
Kim HG; Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania.
Nader GA; Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania.; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania.; Penn State Cancer Institute, The Pennsylvania State University, University Park, Pennsylvania.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2021 Dec 01; Vol. 321 (6), pp. C1000-C1009. Date of Electronic Publication: 2021 Oct 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*toxicity
Muscle Fibers, Skeletal/*drug effects
Oxidative Stress/*drug effects
Protein Biosynthesis/*drug effects
Ribosomes/*drug effects
Animals ; Cell Line ; Hydrogen Peroxide/toxicity ; Mice ; Muscle Fibers, Skeletal/metabolism ; Oxidative Stress/physiology ; Protein Biosynthesis/physiology ; Ribosomes/metabolism
Czasopismo naukowe
Tytuł :
A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells.
Autorzy :
Volta V; Synthis LLC, 430 East 29th Street, Launch Labs, Alexandria Center for Life Sciences, New York, NY, 10016, USA.
Pérez-Baos S; Department of Microbiology, NYU Grossman School of Medicine, New York, NY, 10016, USA.
de la Parra C; Department of Chemistry, Herbert H. Lehman College, City University of New York, The Graduate Center, Biochemistry Ph.D. Program, City University of New York, New York, NY, 10016, USA.
Katsara O; Department of Microbiology, NYU Grossman School of Medicine, New York, NY, 10016, USA.
Ernlund A; Johns Hopkins Applied Physics Lab, 11000 Johns Hopkins Road, Laurel, MD, 20723, USA.
Dornbaum S; Department of Microbiology, NYU Grossman School of Medicine, New York, NY, 10016, USA.
Schneider RJ; Department of Microbiology, NYU Grossman School of Medicine, New York, NY, 10016, USA. .; Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY, 10016, USA. .; Colton Center for Autoimmunity, NYU Grossman School of Medicine, New York, NY, 10016, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Nov 30; Vol. 12 (1), pp. 6979. Date of Electronic Publication: 2021 Nov 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
Immunosuppression Therapy*
Protein Biosynthesis*
Eukaryotic Initiation Factor-3/*metabolism
Eukaryotic Initiation Factor-4G/*metabolism
T-Lymphocytes, Regulatory/*metabolism
Down-Regulation ; Eukaryotic Initiation Factor-3/genetics ; Eukaryotic Initiation Factor-4G/genetics ; Gene Expression Regulation ; HEK293 Cells ; Homeostasis ; Humans ; Lymphocyte Activation ; Mechanistic Target of Rapamycin Complex 1/metabolism ; RNA, Messenger ; Transforming Growth Factor beta1/metabolism
Czasopismo naukowe
Tytuł :
A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division.
Autorzy :
Martini S; Protein Phosphorylation Laboratory, The Francis Crick Institute, London, UK.
Davis K; Protein Phosphorylation Laboratory, The Francis Crick Institute, London, UK.
Faraway R; RNA Network Laboratory, The Francis Crick Institute, London, UK.; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Elze L; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Lockwood N; Protein Phosphorylation Laboratory, The Francis Crick Institute, London, UK.
Jones A; Cell Cycle Laboratory, The Francis Crick Institute, London, UK.
Xie X; Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
McDonald NQ; Signalling and Structural Biology Laboratory, The Francis Crick Institute, London, UK.
Mann DJ; Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
Armstrong A; Department of Chemistry, Imperial College, London, UK.
Ule J; RNA Network Laboratory, The Francis Crick Institute, London, UK.; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Parker PJ; Protein Phosphorylation Laboratory, The Francis Crick Institute, London, UK. .; School of Cancer and Pharmaceutical Sciences, King's College London, Guy's Campus, London, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Nov 26; Vol. 12 (1), pp. 6934. Date of Electronic Publication: 2021 Nov 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosome Segregation*
Mitosis*
Protein Biosynthesis*
Protein Kinase C-epsilon/*metabolism
RNA-Binding Proteins/*metabolism
Aurora Kinase B/metabolism ; HEK293 Cells ; HeLa Cells ; Humans
Czasopismo naukowe

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