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Wyszukujesz frazę ""Protein Conformation"" wg kryterium: Temat


Tytuł:
The role of the half-turn in determining structures of Alzheimer's Aβ wild-type and mutants.
Autorzy:
Hayward S; Laboratory for Computational Biology, School of Computing Sciences, University of East Anglia, Norwich, UK. Electronic address: .
Kitao A; School of Life Science and Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, M6-13, Meguro, Tokyo 152-8550, Japan. Electronic address: .
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Źródło:
Journal of structural biology [J Struct Biol] 2021 Dec; Vol. 213 (4), pp. 107792. Date of Electronic Publication: 2021 Sep 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Molecular Dynamics Simulation*
Mutation*
Protein Conformation*
Alzheimer Disease/*genetics
Amyloid beta-Peptides/*chemistry
Amyloid beta-Peptides/*genetics
Alzheimer Disease/metabolism ; Amino Acid Sequence ; Amyloid beta-Peptides/metabolism ; Humans ; Hydrogen Bonding ; Protein Conformation, beta-Strand ; Protein Multimerization ; Sequence Homology, Amino Acid
Czasopismo naukowe
Tytuł:
Structural snapshot of the mitochondrial protein import gate.
Autorzy:
Araiso Y; Department of Clinical Laboratory Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Japan.
Imai K; Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan.
Endo T; Faculty of Life Sciences, Kyoto Sangyo University, Japan.; Institute for Protein Dynamics, Kyoto Sangyo University, Japan.
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Źródło:
The FEBS journal [FEBS J] 2021 Sep; Vol. 288 (18), pp. 5300-5310. Date of Electronic Publication: 2020 Dec 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Conformation*
Carrier Proteins/*ultrastructure
Mitochondrial Membrane Transport Proteins/*ultrastructure
Saccharomyces cerevisiae Proteins/*ultrastructure
Carrier Proteins/genetics ; Mitochondria/genetics ; Mitochondria/ultrastructure ; Mitochondrial Membrane Transport Proteins/genetics ; Mitochondrial Precursor Protein Import Complex Proteins ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/ultrastructure ; Multiprotein Complexes/genetics ; Multiprotein Complexes/ultrastructure ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand/genetics ; Protein Transport/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/ultrastructure ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Tytuł:
Competition in drug binding and … the race to equilibrium.
Autorzy:
Vauquelin G; Department of Molecular and Biochemical Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.
Maes D; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.
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Źródło:
Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2023 Feb; Vol. 37 (1), pp. 147-157. Date of Electronic Publication: 2022 Aug 30.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Conformation*
Ligands ; Kinetics ; Protein Binding
Czasopismo naukowe
Tytuł:
The Impact of N -Acryloyllysine Piperazides on the Conformational Dynamics of Transglutaminase 2.
Autorzy:
Heerwig A; Kurt-Schwabe-Institut für Mess- und Sensortechnik Meinsberg e.V., 04736 Waldheim, Germany.
Kick A; Kurt-Schwabe-Institut für Mess- und Sensortechnik Meinsberg e.V., 04736 Waldheim, Germany.
Sommerfeld P; Institutes I & II of Pharmacology, Center of Pharmacology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
Eimermacher S; Institutes I & II of Pharmacology, Center of Pharmacology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
Hartung F; Institutes I & II of Pharmacology, Center of Pharmacology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
Laube M; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328 Dresden, Germany.; School of Science, Faculty of Chemistry and Food Chemistry, Technische Universität Dresden, 01062 Dresden, Germany.
Fischer D; Institutes I & II of Pharmacology, Center of Pharmacology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
Pietzsch HJ; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328 Dresden, Germany.; School of Science, Faculty of Chemistry and Food Chemistry, Technische Universität Dresden, 01062 Dresden, Germany.
Pietzsch J; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328 Dresden, Germany.; School of Science, Faculty of Chemistry and Food Chemistry, Technische Universität Dresden, 01062 Dresden, Germany.
Löser R; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328 Dresden, Germany.; School of Science, Faculty of Chemistry and Food Chemistry, Technische Universität Dresden, 01062 Dresden, Germany.
Mertig M; Kurt-Schwabe-Institut für Mess- und Sensortechnik Meinsberg e.V., 04736 Waldheim, Germany.; School of Science, Faculty of Chemistry and Food Chemistry, Technische Universität Dresden, 01062 Dresden, Germany.
Pietsch M; Institutes I & II of Pharmacology, Center of Pharmacology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
Wodtke R; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328 Dresden, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 13; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 13.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Glutamine gamma Glutamyltransferase 2*/chemistry
Protein Conformation*
Molecular Conformation ; Transglutaminases/metabolism
Czasopismo naukowe
Tytuł:
Molecular dynamics simulation of TMEM16A channel: Linking structure with gating.
Autorzy:
Shi S; State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300401, China; Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province, Hebei University of Technology, Tianjin 300401, China; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Science, Hebei University of Technology, Tianjin 300401, China.
Pang C; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Science, Hebei University of Technology, Tianjin 300401, China.
Ren S; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Science, Hebei University of Technology, Tianjin 300401, China.
Sun F; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Science, Hebei University of Technology, Tianjin 300401, China.
Ma B; State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300401, China; Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province, Hebei University of Technology, Tianjin 300401, China; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Science, Hebei University of Technology, Tianjin 300401, China.
Guo S; College of Life Science, Hebei University, Baoding 071002, Hebei, China.
Li J; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Science, Hebei University of Technology, Tianjin 300401, China.
Chen Y; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Science, Hebei University of Technology, Tianjin 300401, China.
An H; State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300401, China; Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province, Hebei University of Technology, Tianjin 300401, China; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Science, Hebei University of Technology, Tianjin 300401, China. Electronic address: hailong_.
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Źródło:
Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2022 Feb 01; Vol. 1864 (1), pp. 183777. Date of Electronic Publication: 2021 Sep 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Conformation*
Anoctamin-1/*ultrastructure
Cell Communication/*genetics
Protein Conformation, alpha-Helical/*genetics
Anoctamin-1/chemistry ; Anoctamin-1/genetics ; Calcium/chemistry ; Humans ; Hydrophobic and Hydrophilic Interactions ; Molecular Dynamics Simulation ; Static Electricity ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Toward Real Real-Space Refinement of Atomic Models.
Autorzy:
Urzhumtsev AG; Centre for Integrative Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS-INSERM-UdS, 1 rue Laurent Fries, BP 10142, 67404 Illkirch, France.; Faculté des Sciences et Technologies, Université de Lorraine, BP 239, 54506 Vandoeuvre-lès-Nancy, France.
Lunin VY; Institute of Mathematical Problems of Biology RAS, Keldysh Institute of Applied Mathematics of Russian Academy of Sciences, 142290 Pushchino, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Oct 11; Vol. 23 (20). Date of Electronic Publication: 2022 Oct 11.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Conformation*
Models, Molecular ; Macromolecular Substances/chemistry ; Crystallography, X-Ray ; Cryoelectron Microscopy/methods
Czasopismo naukowe
Tytuł:
De novo design of transmembrane β barrels.
Autorzy:
Vorobieva AA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
White P; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, USA.
Liang B; Department of Molecular Physiology and Biological Physics and Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA 22903, USA.
Horne JE; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, USA.
Bera AK; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Chow CM; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Gerben S; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Marx S; Department of Molecular Engineering and Sciences, University of Washington, Seattle, WA 98195, USA.
Kang A; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Stiving AQ; Department of Chemistry and Biochemistry, Resource for Native Mass Spectrometry Guided Structural Biology, The Ohio State University, Columbus, OH 43210, USA.
Harvey SR; Department of Chemistry and Biochemistry, Resource for Native Mass Spectrometry Guided Structural Biology, The Ohio State University, Columbus, OH 43210, USA.
Marx DC; TC Jenkins Department of Biophysics Johns Hopkins University, Baltimore, MD 21218, USA.
Khan GN; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, USA.
Fleming KG; TC Jenkins Department of Biophysics Johns Hopkins University, Baltimore, MD 21218, USA.
Wysocki VH; Department of Chemistry and Biochemistry, Resource for Native Mass Spectrometry Guided Structural Biology, The Ohio State University, Columbus, OH 43210, USA.
Brockwell DJ; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, USA.
Tamm LK; Department of Molecular Physiology and Biological Physics and Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA 22903, USA.
Radford SE; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, USA.
Baker D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. .; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2021 Feb 19; Vol. 371 (6531).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Computer Simulation*
Models, Molecular*
Protein Conformation, beta-Strand*
Protein Engineering*
Membrane Proteins/*chemistry
Amino Acid Sequence ; Crystallography, X-Ray ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Lipid Bilayers ; Magnetic Resonance Spectroscopy ; Membranes, Artificial ; Micelles ; Protein Conformation ; Protein Folding ; Protein Stability
Czasopismo naukowe
Tytuł:
Structure relationship of metalloporphyrins in inhibiting the aggregation of hIAPP.
Autorzy:
Wu J; Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science & Technology, Wuhan 430074, PR China; Department of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Yin X; Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science & Technology, Wuhan 430074, PR China.
Ye H; Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science & Technology, Wuhan 430074, PR China; School of Chemistry and Chemical Engineering, Jinggangshan University, Ji'an, Jiangxi 343009, PR China.
Gao Z; Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science & Technology, Wuhan 430074, PR China. Electronic address: .
Li H; Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science & Technology, Wuhan 430074, PR China. Electronic address: .
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Źródło:
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jan 15; Vol. 167, pp. 141-150. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji:
Journal Article
MeSH Terms:
Models, Molecular*
Protein Aggregates*
Protein Conformation*
Islet Amyloid Polypeptide/*chemistry
Metalloporphyrins/*chemistry
Amyloid/chemistry ; Amyloid/ultrastructure ; Circular Dichroism ; Humans ; Islet Amyloid Polypeptide/metabolism ; Microscopy, Atomic Force ; Molecular Structure ; Protein Conformation, beta-Strand ; Protein Stability ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Structural effects of the highly protective V127 polymorphism on human prion protein.
Autorzy:
Hosszu LLP; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London, W1W 7FF, UK.
Conners R; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London, W1W 7FF, UK.; University of Bristol, School of Biochemistry, Biomedical Sciences Building, University Walk, Clifton, BS8 1TD, UK.; Living Systems Institute, University of Exeter, Stocker Road, Exeter, EX4 4QD, UK.
Sangar D; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London, W1W 7FF, UK.
Batchelor M; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London, W1W 7FF, UK.
Sawyer EB; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London, W1W 7FF, UK.; London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
Fisher S; Diamond Light Source, Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, UK.; ESRF, 71, Avenue des Martyrs, CS 40220, 38043, Grenoble Cedex 9, France.
Cliff MJ; Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.
Hounslow AM; Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK.
McAuley K; Diamond Light Source, Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, UK.
Leo Brady R; University of Bristol, School of Biochemistry, Biomedical Sciences Building, University Walk, Clifton, BS8 1TD, UK.
Jackson GS; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London, W1W 7FF, UK.
Bieschke J; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London, W1W 7FF, UK.
Waltho JP; Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.; Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK.
Collinge J; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London, W1W 7FF, UK. .
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Źródło:
Communications biology [Commun Biol] 2020 Jul 29; Vol. 3 (1), pp. 402. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Conformation*
Prion Diseases/*genetics
Prion Proteins/*genetics
Prions/*genetics
Animals ; Humans ; Point Mutation/genetics ; Prion Diseases/pathology ; Prion Proteins/ultrastructure ; Prions/ultrastructure ; Protein Conformation, beta-Strand/genetics
Czasopismo naukowe
Tytuł:
Buried interfaces: general discussion.
Autorzy:
Aureau D
Bartels-Rausch T
Buckingham MA
Conard T
Dell'Angela M
Flavell W
Gibson JS
Held G
Isaacs M
Kastorp CFP
Krizan A
Lindsay R
Lömker P
Morgan D
Osundare A
Palgrave R
Pei Y
Renault O
Roberts A
Rupprechter G
Shard A
Solal F
Spencer B
Weatherup R
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Źródło:
Faraday discussions [Faraday Discuss] 2022 Aug 25; Vol. 236 (0), pp. 338-351. Date of Electronic Publication: 2022 Aug 25.
Typ publikacji:
Congress
MeSH Terms:
Protein Conformation*
Protein Binding
Tytuł:
Conserved conformational dynamics determine enzyme activity.
Autorzy:
Torgeson KR; Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ, USA.; Department of Cell Biology, University of Connecticut Health, Farmington, CT, USA.
Clarkson MW; Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ, USA.
Granata D; Structural Biology and NMR Laboratory, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Lindorff-Larsen K; Structural Biology and NMR Laboratory, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Page R; Department of Cell Biology, University of Connecticut Health, Farmington, CT, USA.
Peti W; Department of Molecular Biology and Biophysics, University of Connecticut Health, Farmington, CT, USA.
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Źródło:
Science advances [Sci Adv] 2022 Aug 05; Vol. 8 (31), pp. eabo5546. Date of Electronic Publication: 2022 Aug 03.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Conformation*
Catalytic Domain
Czasopismo naukowe
Tytuł:
The conformational change of the protease inhibitor α 2 -macroglobulin is triggered by the retraction of the cleaved bait region from a central channel.
Autorzy:
Harwood SL; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Diep K; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Nielsen NS; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Jensen KT; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Enghild JJ; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2022 Aug; Vol. 298 (8), pp. 102230. Date of Electronic Publication: 2022 Jul 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Conformation*
alpha-Macroglobulins*/chemistry
Amino Acid Sequence ; Disulfides
Czasopismo naukowe
Tytuł:
A gating mechanism of K2P channels by their selectivity filter.
Autorzy:
Yang F; Department of Biophysics, and Kidney Disease Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
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Źródło:
Journal of molecular cell biology [J Mol Cell Biol] 2022 Jul 05; Vol. 14 (3).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Conformation*
Czasopismo naukowe
Tytuł:
Venus: Elucidating the Impact of Amino Acid Variants on Protein Function Beyond Structure Destabilisation.
Autorzy:
Ferla MP; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Oxford NIHR Biomedical Research Centre, Oxford, UK. Electronic address: .
Pagnamenta AT; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Oxford NIHR Biomedical Research Centre, Oxford, UK. Electronic address: https:.
Koukouflis L; Centre for Medicines Discovery, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Taylor JC; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Oxford NIHR Biomedical Research Centre, Oxford, UK.
Marsden BD; Centre for Medicines Discovery, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK. Electronic address: https:.
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Źródło:
Journal of molecular biology [J Mol Biol] 2022 Jun 15; Vol. 434 (11), pp. 167567. Date of Electronic Publication: 2022 Mar 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amino Acid Substitution*/genetics
Disease*/genetics
Internet Use*
Protein Conformation*
Proteins*/chemistry
Proteins*/genetics
Software*
Computational Biology/methods ; Genetic Code ; Humans
Czasopismo naukowe
Tytuł:
FTMove: A Web Server for Detection and Analysis of Cryptic and Allosteric Binding Sites by Mapping Multiple Protein Structures.
Autorzy:
Egbert M; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Jones G; Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY 11794, USA.
Collins MR; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Kozakov D; Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY 11794, USA.
Vajda S; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA; Department of Chemistry, Boston University, Boston, MA 02215, USA. Electronic address: .
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Źródło:
Journal of molecular biology [J Mol Biol] 2022 Jun 15; Vol. 434 (11), pp. 167587. Date of Electronic Publication: 2022 Apr 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Internet Use*
Protein Conformation*
Proteins*/chemistry
Software*
Allosteric Site ; Ligands
Czasopismo naukowe
Tytuł:
EvoRator: Prediction of Residue-level Evolutionary Rates from Protein Structures Using Machine Learning.
Autorzy:
Nagar N; The Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Ben Tal N; School of Neurobiology, Biochemistry & Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Pupko T; The Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: .
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Źródło:
Journal of molecular biology [J Mol Biol] 2022 Jun 15; Vol. 434 (11), pp. 167538. Date of Electronic Publication: 2022 Mar 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Internet Use*
Machine Learning*
Protein Conformation*
Proteins*/chemistry
Proteins*/genetics
Software*
Algorithms ; Humans ; Phylogeny ; Sequence Alignment
Czasopismo naukowe
Tytuł:
The long β2,3-sheets encoded by redundant sequences play an integral role in the channel function of P2X7 receptors.
Autorzy:
Ma XF; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, China; School of Basic Medicine and Clinical Pharmacy and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Wang TT; School of Basic Medicine and Clinical Pharmacy and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Wang WH; School of Basic Medicine and Clinical Pharmacy and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Guan L; School of Basic Medicine and Clinical Pharmacy and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Guo CR; School of Basic Medicine and Clinical Pharmacy and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Li XH; School of Basic Medicine and Clinical Pharmacy and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Lei YT; School of Basic Medicine and Clinical Pharmacy and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Fan YZ; Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yang XN; School of Basic Medicine and Clinical Pharmacy and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Hattori M; State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai, China.
Nureki O; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Zhu MX; Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Yu Y; School of Basic Medicine and Clinical Pharmacy and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China. Electronic address: .
Tian Y; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, China. Electronic address: .
Wang J; School of Basic Medicine and Clinical Pharmacy and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2022 Jun; Vol. 298 (6), pp. 102002. Date of Electronic Publication: 2022 Apr 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenosine Triphosphate*/metabolism
Protein Conformation, beta-Strand*/genetics
Receptors, Purinergic P2X7*/chemistry
Receptors, Purinergic P2X7*/genetics
Receptors, Purinergic P2X7*/metabolism
Humans ; Inflammation ; Protein Stability ; Transcriptional Activation
Czasopismo naukowe
Tytuł:
Structural features of split and unsplit βαβ-units.
Autorzy:
Kargatov AM; Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russian Federation. Electronic address: .
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Źródło:
Journal of structural biology [J Struct Biol] 2020 Jan 01; Vol. 209 (1), pp. 107427. Date of Electronic Publication: 2019 Nov 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Conformation*
Amino Acid Sequence/*genetics
Amino Acids/*chemistry
Amino Acids/genetics ; Hydrophobic and Hydrophilic Interactions ; Protein Conformation, alpha-Helical/genetics ; Protein Conformation, beta-Strand/genetics
Czasopismo naukowe
Tytuł:
Terminal charges modulate the pore forming activity of cationic amphipathic helices.
Autorzy:
Strandberg E; Karlsruhe Institute of Technology (KIT), Institute of Biological Interfaces (IBG-2), POB 3640, 76021 Karlsruhe, Germany.
Bentz D; KIT, Institute of Organic Chemistry, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany.
Wadhwani P; Karlsruhe Institute of Technology (KIT), Institute of Biological Interfaces (IBG-2), POB 3640, 76021 Karlsruhe, Germany.
Bürck J; Karlsruhe Institute of Technology (KIT), Institute of Biological Interfaces (IBG-2), POB 3640, 76021 Karlsruhe, Germany.
Ulrich AS; Karlsruhe Institute of Technology (KIT), Institute of Biological Interfaces (IBG-2), POB 3640, 76021 Karlsruhe, Germany; KIT, Institute of Organic Chemistry, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany. Electronic address: .
Pokaż więcej
Źródło:
Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2020 Apr 01; Vol. 1862 (4), pp. 183243. Date of Electronic Publication: 2020 Feb 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Conformation*
Antimicrobial Cationic Peptides/*chemistry
Lipid Bilayers/*chemistry
Oligopeptides/*chemistry
Amino Acid Sequence/genetics ; Cell Membrane/chemistry ; Hydrophobic and Hydrophilic Interactions ; Nuclear Magnetic Resonance, Biomolecular ; Oligopeptides/genetics ; Protein Conformation, alpha-Helical ; Protein Structure, Secondary/genetics
Czasopismo naukowe

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