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Wyszukujesz frazę ""Protein Conformation, alpha-Helical"" wg kryterium: Temat


Tytuł :
Insights Into the Micelle-Induced β-Hairpin-to-α-Helix Transition of a LytA-Derived Peptide by Photo-CIDNP Spectroscopy.
Autorzy :
Gomez MV; IRICA, Department of Inorganic, Organic and Biochemistry, Faculty of Chemical Sciences and Technologies, Universidad de Castilla-La Mancha (UCLM), Av. Camilo José Cela 10, 13071 Ciudad Real, Spain.
Ruiz-Castañeda M; IRICA, Department of Inorganic, Organic and Biochemistry, Faculty of Chemical Sciences and Technologies, Universidad de Castilla-La Mancha (UCLM), Av. Camilo José Cela 10, 13071 Ciudad Real, Spain.
Nitschke P; Institute of Organic Chemistry, University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany.
Gschwind RM; Institute of Organic Chemistry, University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany.
Jiménez MA; Departamento de Química-Física Biológica, Instituto de Química Física Rocasolano (IQFR-CSIC), Serrano 119, 28006 Madrid, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 22; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Micelles*
Protein Conformation, alpha-Helical*
Peptides/*chemistry
Tyrosine/*chemistry
Light ; Nuclear Magnetic Resonance, Biomolecular ; Photochemical Processes ; Spectrum Analysis
Czasopismo naukowe
Tytuł :
Prediction of amphipathic helix-membrane interactions with Rosetta.
Autorzy :
Gulsevin A; Department of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.
Meiler J; Department of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.; Institute for Drug Discovery, Leipzig University Medical School, 04103 Leipzig, Germany.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2021 Mar 17; Vol. 17 (3), pp. e1008818. Date of Electronic Publication: 2021 Mar 17 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Membrane Proteins*/chemistry
Membrane Proteins*/metabolism
Molecular Dynamics Simulation*
Protein Conformation, alpha-Helical*
Computational Biology/*methods
Algorithms ; Databases, Protein ; Protein Binding
Czasopismo naukowe
Tytuł :
An Amphipathic Alpha-Helix Domain from Poliovirus 2C Protein Tubulate Lipid Vesicles.
Autorzy :
Varkey J; Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, USA.
Zhang J; School of Plant and Environmental Sciences, Virginia Tech, Blacksburg, VA 24061, USA.
Kim J; Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA.
George G; Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, USA.
He G; School of Plant and Environmental Sciences, Virginia Tech, Blacksburg, VA 24061, USA.
Belov G; Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA.
Langen R; Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, USA.
Wang X; School of Plant and Environmental Sciences, Virginia Tech, Blacksburg, VA 24061, USA.
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Źródło :
Viruses [Viruses] 2020 Dec 18; Vol. 12 (12). Date of Electronic Publication: 2020 Dec 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Protein Conformation, alpha-Helical*
Carrier Proteins/*chemistry
Viral Nonstructural Proteins/*chemistry
Amino Acid Sequence ; Carrier Proteins/metabolism ; Humans ; Multiprotein Complexes ; Poliomyelitis/virology ; Poliovirus/physiology ; Protein Binding ; Protein Structure, Secondary ; Structure-Activity Relationship ; Viral Nonstructural Proteins/metabolism ; Virus Replication
Czasopismo naukowe
Tytuł :
The SERCA residue Glu340 mediates interdomain communication that guides Ca transport.
Autorzy :
Geurts MMG; Department of Biochemistry, University of Oxford, OX1 3QU Oxford, United Kingdom.
Clausen JD; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.
Arnou B; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.; Institute for Integrative Biology of the Cell (I2BC), Commissariat à l'Energie Atomique et aux Energies Alternatives, CNRS, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
Montigny C; Institute for Integrative Biology of the Cell (I2BC), Commissariat à l'Energie Atomique et aux Energies Alternatives, CNRS, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
Lenoir G; Institute for Integrative Biology of the Cell (I2BC), Commissariat à l'Energie Atomique et aux Energies Alternatives, CNRS, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
Corey RA; Department of Biochemistry, University of Oxford, OX1 3QU Oxford, United Kingdom.
Jaxel C; Institute for Integrative Biology of the Cell (I2BC), Commissariat à l'Energie Atomique et aux Energies Alternatives, CNRS, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
Møller JV; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
Nissen P; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.; Danish Research Institute of Translational Neuroscience-DANDRITE, Nordic European Molecular Biology Laboratory Partnership for Molecular Medicine, Aarhus University, 8000 Aarhus C, Denmark.
Andersen JP; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
le Maire M; Institute for Integrative Biology of the Cell (I2BC), Commissariat à l'Energie Atomique et aux Energies Alternatives, CNRS, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
Bublitz M; Department of Biochemistry, University of Oxford, OX1 3QU Oxford, United Kingdom; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 08; Vol. 117 (49), pp. 31114-31122. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Conformation, alpha-Helical*
Calcium/*metabolism
Calcium-Binding Proteins/*ultrastructure
Sarcoplasmic Reticulum Calcium-Transporting ATPases/*ultrastructure
Adenosine Triphosphate/chemistry ; Amino Acid Sequence/genetics ; Asparagine/chemistry ; Binding Sites/genetics ; Calcium/chemistry ; Calcium Signaling/genetics ; Calcium-Binding Proteins/chemistry ; Calcium-Binding Proteins/genetics ; Crystallography, X-Ray ; Cytosol/metabolism ; Escherichia coli/enzymology ; Humans ; Hydrogen Bonding ; Kinetics ; Molecular Dynamics Simulation ; Mutation/genetics ; Phosphorylation/genetics ; Protein Domains/genetics ; Protein Structure, Secondary ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/chemistry ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism ; Tryptophan/chemistry
Czasopismo naukowe
Tytuł :
Affinity Control of Monosaccharide Conjugated Peptides against Lectins with a Set of Amino Acid Substitutions on α-Helical Structures.
Autorzy :
Maeda Y; Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, Midori-ku, Yokohama, 226-8501, Japan.
Sawada T; Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, Midori-ku, Yokohama, 226-8501, Japan.
Takahashi T; Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, Midori-ku, Yokohama, 226-8501, Japan.
Yuasa H; Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, Midori-ku, Yokohama, 226-8501, Japan.
Mihara H; Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, Midori-ku, Yokohama, 226-8501, Japan.
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Źródło :
Bioconjugate chemistry [Bioconjug Chem] 2020 Nov 18; Vol. 31 (11), pp. 2533-2540. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Substitution*
Protein Conformation, alpha-Helical*
Lectins/*chemistry
Monosaccharides/*chemistry
Peptides/*chemistry
Amino Acid Sequence ; Circular Dichroism ; Thermodynamics
Czasopismo naukowe
Tytuł :
Regulation and functional consequences of mGlu 4 RNA editing.
Autorzy :
Hofmann CS; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA.; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, USA.
Carrington S; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA.; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, USA.
Keller AN; Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Gregory KJ; Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Niswender CM; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA.; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, USA.; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2021 Oct; Vol. 27 (10), pp. 1220-1240. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article
MeSH Terms :
RNA Editing*
RNA, Messenger/*genetics
Receptors, Metabotropic Glutamate/*genetics
Adenosine Deaminase/genetics ; Adenosine Deaminase/metabolism ; Amino Acid Sequence ; Animals ; Base Pairing ; Base Sequence ; Birds ; Cerebral Cortex/cytology ; Cerebral Cortex/metabolism ; Corpus Striatum/cytology ; Corpus Striatum/metabolism ; HEK293 Cells ; Hippocampus/cytology ; Hippocampus/metabolism ; Humans ; Models, Molecular ; Neurons/cytology ; Neurons/metabolism ; Nucleic Acid Conformation ; Point Mutation ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Metabotropic Glutamate/chemistry ; Receptors, Metabotropic Glutamate/metabolism ; Reptiles ; Sequence Homology, Amino Acid
Czasopismo naukowe
Tytuł :
Human CALHM5: Insight in large pore lipid gating ATP channel and associated neurological pathologies.
Autorzy :
Bhat EA; Life Science Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, P.R. China. .; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India. .
Sajjad N; Department of Biochemistry, University of Kashmir, Hazratbal, Jammu and Kashmir, India.
Banawas S; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah, 11952, Kingdom of Saudi Arabia. .; Health and Basic Sciences Research Center, Majmaah University, Majmaah, 11952, Saudi Arabia. .; Departments of Biomedical Sciences, Oregon State University, Corvallis, OR, 97331, USA. .
Khan J; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah, 11952, Kingdom of Saudi Arabia.; Health and Basic Sciences Research Center, Majmaah University, Majmaah, 11952, Saudi Arabia.
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Oct; Vol. 476 (10), pp. 3711-3718. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Membrane Glycoproteins*/chemistry
Membrane Glycoproteins*/metabolism
Membrane Potentials*
Adenosine Triphosphate/*metabolism
Alzheimer Disease/*metabolism
Depression/*metabolism
Alzheimer Disease/pathology ; Calcium/metabolism ; Depression/pathology ; Humans ; Protein Conformation, alpha-Helical
Czasopismo naukowe
Tytuł :
Linearized esculentin-2EM shows pH dependent antibacterial activity with an alkaline optimum.
Autorzy :
Malik E; College of Medicine and Health, University of Exeter Medical School, Heavitree Road, Exeter, EX1 2LU, UK.
Phoenix DA; Office of the Vice Chancellor, London South Bank University, 103 Borough Road, London, SE1 0AA, UK.
Snape TJ; School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK.
Harris F; School of Natural Sciences, University of Central Lancashire, Preston, PR1 2HE, UK.
Singh J; School of Natural Sciences, University of Central Lancashire, Preston, PR1 2HE, UK.
Morton LHG; School of Natural Sciences, University of Central Lancashire, Preston, PR1 2HE, UK.
Dennison SR; School of Pharmacy and Biological Sciences, University of Central Lancashire, Preston, PR1 2HE, UK. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Oct; Vol. 476 (10), pp. 3729-3744. Date of Electronic Publication: 2021 Jun 06.
Typ publikacji :
Journal Article
MeSH Terms :
Amphibian Proteins*/chemistry
Amphibian Proteins*/pharmacology
Anti-Bacterial Agents*/chemistry
Anti-Bacterial Agents*/pharmacology
Antimicrobial Cationic Peptides*/chemistry
Antimicrobial Cationic Peptides*/pharmacology
Gram-Positive Bacteria/*growth & development
Hydrogen-Ion Concentration ; Protein Conformation, alpha-Helical
Czasopismo naukowe
Tytuł :
Discovery of a new light-driven Li -pumping rhodopsin with DTG motif.
Autorzy :
Cho SG; Department of Life Science and Institute of Biological Interfaces, Sogang University, Seoul 04107, Republic of Korea.
Shim JG; Department of Life Science and Institute of Biological Interfaces, Sogang University, Seoul 04107, Republic of Korea.
Choun K; Department of Life Science and Institute of Biological Interfaces, Sogang University, Seoul 04107, Republic of Korea.
Meas S; Department of Life Science and Institute of Biological Interfaces, Sogang University, Seoul 04107, Republic of Korea; Department of Biology, Faculty of Science, Royal University of Phnom Penh, Phnom Penh 12000, Cambodia.
Kang KW; Department of Life Science and Institute of Biological Interfaces, Sogang University, Seoul 04107, Republic of Korea.
Kim JH; Department of Life Science and Institute of Biological Interfaces, Sogang University, Seoul 04107, Republic of Korea.
Cho HS; Department of Life Science and Institute of Biological Interfaces, Sogang University, Seoul 04107, Republic of Korea.
Jung KH; Department of Life Science and Institute of Biological Interfaces, Sogang University, Seoul 04107, Republic of Korea. Electronic address: .
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Źródło :
Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2021 Oct; Vol. 223, pp. 112285. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Journal Article
MeSH Terms :
Lithium/*metabolism
Rhodopsins, Microbial/*metabolism
Sodium/*metabolism
Amino Acid Motifs ; Hydrogen-Ion Concentration ; Ion Transport/radiation effects ; Light ; Lithium/chemistry ; Methylobacteriaceae/metabolism ; Mutagenesis, Site-Directed ; Phylogeny ; Protein Binding ; Protein Conformation, alpha-Helical ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/isolation & purification ; Rhodopsins, Microbial/chemistry ; Rhodopsins, Microbial/classification ; Rhodopsins, Microbial/genetics ; Sodium/chemistry
SCR Organism :
Methylorubrum populi
Czasopismo naukowe
Tytuł :
Enumeration and comprehensive in-silico modeling of three-helix bundle structures composed of typical αα-hairpins.
Autorzy :
Sakuma K; SOKENDAI, The Graduate University for Advanced Studies, 38 Nishigonaka, Myodaiji, Okazaki, 444-8585, Japan. .; Institute for Molecular Science, 38 Nishigonaka, Myodaiji, Okazaki, 444-8585, Japan. .
Minami S; Independent Researcher, Seattle, WA, USA.
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2021 Sep 27; Vol. 22 (1), pp. 465. Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Journal Article
MeSH Terms :
Proteins*
Amino Acid Sequence ; Protein Conformation ; Protein Conformation, alpha-Helical ; Protein Structure, Secondary
Czasopismo naukowe
Tytuł :
Structural characterization of modified whey protein isolates using cold plasma treatment and its applications in emulsion oleogels.
Autorzy :
Gong W; School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
Guo XL; School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
Huang HB; School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
Li X; School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
Xu Y; School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
Hu JN; School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Sep 15; Vol. 356, pp. 129703. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article
MeSH Terms :
Emulsions/*chemistry
Plasma Gases/*chemistry
Whey Proteins/*chemistry
Escherichia coli/drug effects ; Oils/chemistry ; Organic Chemicals/chemistry ; Organic Chemicals/pharmacology ; Protein Conformation, alpha-Helical ; Rheology ; Staphylococcus aureus/drug effects ; Surface Tension ; Viscosity ; Water/chemistry
Czasopismo naukowe
Tytuł :
Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling.
Autorzy :
van der Stel AX; Univ. Bordeaux, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, ARNA, UMR 5320, U1212, Institut Européen de Chimie et Biologie, Pessac, France.
Gordon ER; Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL, USA.
Sengupta A; Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL, USA.
Martínez AK; Department of Biology, Texas A&M University, College Station, TX, USA.
Klepacki D; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Perry TN; Univ. Bordeaux, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, ARNA, UMR 5320, U1212, Institut Européen de Chimie et Biologie, Pessac, France.
Herrero Del Valle A; Univ. Bordeaux, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, ARNA, UMR 5320, U1212, Institut Européen de Chimie et Biologie, Pessac, France.
Vázquez-Laslop N; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Sachs MS; Department of Biology, Texas A&M University, College Station, TX, USA. .
Cruz-Vera LR; Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL, USA. .
Innis CA; Univ. Bordeaux, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, ARNA, UMR 5320, U1212, Institut Européen de Chimie et Biologie, Pessac, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 09; Vol. 12 (1), pp. 5340. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Expression Regulation, Bacterial*
Peptide Chain Initiation, Translational*
Escherichia coli/*genetics
Ribosomes/*genetics
Tryptophan/*chemistry
Amino Acid Substitution ; Binding Sites ; Cryoelectron Microscopy ; Escherichia coli/metabolism ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Models, Molecular ; Mutation ; Operon ; Peptide Chain Termination, Translational ; Peptide Termination Factors/genetics ; Peptide Termination Factors/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; RNA, Transfer, Amino Acyl/genetics ; RNA, Transfer, Amino Acyl/metabolism ; Ribosomes/metabolism ; Ribosomes/ultrastructure ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł :
DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation.
Autorzy :
Hou Z; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, United States.; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Wydorski PM; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, United States.; Molecular Biophysics Program, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Perez VA; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, United States.; Molecular Biophysics Program, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Mendoza-Oliva A; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Ryder BD; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, United States.; Molecular Biophysics Program, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Mirbaha H; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Kashmer O; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Joachimiak LA; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, United States. .; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, United States. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 09; Vol. 12 (1), pp. 5338. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid/*chemistry
Heat-Shock Proteins/*chemistry
Molecular Chaperones/*chemistry
Protein Aggregates/*genetics
Tauopathies/*genetics
tau Proteins/*chemistry
Amyloid/antagonists & inhibitors ; Amyloid/genetics ; Amyloid/metabolism ; Animals ; Binding Sites ; Brain/metabolism ; Brain/pathology ; Cloning, Molecular ; Disease Models, Animal ; Gene Expression ; HEK293 Cells ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Humans ; Mice ; Models, Molecular ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Mutation ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Folding ; Protein Interaction Domains and Motifs ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Substrate Specificity ; Tauopathies/metabolism ; Tauopathies/pathology ; Thermodynamics ; tau Proteins/genetics ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks.
Autorzy :
Funk J; Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany.
Merino F; Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany.; Department of Protein Evolution, Max Planck Institute for Developmental Biology, Tübingen, Germany.
Schaks M; Division of Molecular Cell Biology, Zoological Institute, Technische Universität Braunschweig, Braunschweig, Germany.; Department of Cell Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Rottner K; Division of Molecular Cell Biology, Zoological Institute, Technische Universität Braunschweig, Braunschweig, Germany.; Department of Cell Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Raunser S; Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany. .
Bieling P; Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 09; Vol. 12 (1), pp. 5329. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Actin Capping Proteins/*metabolism
Actin Cytoskeleton/*metabolism
Actin-Related Protein 2-3 Complex/*metabolism
Actins/*metabolism
Cytoskeleton/*metabolism
Melanocytes/*metabolism
Actin Capping Proteins/chemistry ; Actin Capping Proteins/genetics ; Actin Cytoskeleton/ultrastructure ; Actin-Related Protein 2-3 Complex/chemistry ; Actin-Related Protein 2-3 Complex/genetics ; Actins/chemistry ; Actins/genetics ; Animals ; Binding Sites ; Cattle ; Cytoskeleton/ultrastructure ; Gelsolin/chemistry ; Gelsolin/genetics ; Gelsolin/metabolism ; Gene Expression Regulation ; Humans ; Intercellular Signaling Peptides and Proteins/chemistry ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Kinetics ; Melanocytes/cytology ; Melanoma, Experimental/genetics ; Melanoma, Experimental/metabolism ; Melanoma, Experimental/pathology ; Mice ; Models, Molecular ; Profilins/chemistry ; Profilins/genetics ; Profilins/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Thymus Gland/cytology ; Thymus Gland/metabolism ; Wiskott-Aldrich Syndrome Protein, Neuronal/chemistry ; Wiskott-Aldrich Syndrome Protein, Neuronal/genetics ; Wiskott-Aldrich Syndrome Protein, Neuronal/metabolism
Czasopismo naukowe
Tytuł :
SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma.
Autorzy :
Andreano E; Monoclonal Antibody Discovery Lab, Fondazione Toscana Life Sciences, 53100 Siena, Italy.
Piccini G; VisMederi S.r.l., 53100 Siena, Italy.
Licastro D; ARGO Open Lab Platform for Genome Sequencing, 34149 Trieste, Italy.
Casalino L; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093.
Johnson NV; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712.
Paciello I; Monoclonal Antibody Discovery Lab, Fondazione Toscana Life Sciences, 53100 Siena, Italy.
Dal Monego S; ARGO Open Lab Platform for Genome Sequencing, 34149 Trieste, Italy.
Pantano E; Monoclonal Antibody Discovery Lab, Fondazione Toscana Life Sciences, 53100 Siena, Italy.
Manganaro N; Monoclonal Antibody Discovery Lab, Fondazione Toscana Life Sciences, 53100 Siena, Italy.
Manenti A; VisMederi S.r.l., 53100 Siena, Italy.; VisMederi Research S.r.l., 53100 Siena, Italy.
Manna R; VisMederi S.r.l., 53100 Siena, Italy.
Casa E; VisMederi S.r.l., 53100 Siena, Italy.; VisMederi Research S.r.l., 53100 Siena, Italy.
Hyseni I; VisMederi S.r.l., 53100 Siena, Italy.; VisMederi Research S.r.l., 53100 Siena, Italy.
Benincasa L; VisMederi Research S.r.l., 53100 Siena, Italy.
Montomoli E; VisMederi S.r.l., 53100 Siena, Italy.; VisMederi Research S.r.l., 53100 Siena, Italy.; Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
Amaro RE; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093.
McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712.
Rappuoli R; Monoclonal Antibody Discovery Lab, Fondazione Toscana Life Sciences, 53100 Siena, Italy; .; Faculty of Medicine, Imperial College, SW7 2DD London, United Kingdom.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Sep 07; Vol. 118 (36).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Amino Acid Substitution*
Angiotensin-Converting Enzyme 2/*immunology
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
COVID-19/*immunology
SARS-CoV-2/*genetics
Spike Glycoprotein, Coronavirus/*immunology
Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/genetics ; Animals ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/genetics ; Antibodies, Neutralizing/pharmacology ; Antibodies, Viral/chemistry ; Antibodies, Viral/genetics ; Antibodies, Viral/pharmacology ; Binding Sites ; COVID-19/genetics ; COVID-19/virology ; Chlorocebus aethiops ; Convalescence ; Gene Expression ; Humans ; Immune Evasion ; Immune Sera/chemistry ; Models, Molecular ; Mutation ; Neutralization Tests ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Vero Cells
Czasopismo naukowe
Tytuł :
Spectroscopic glimpses of the transition state of ATP hydrolysis trapped in a bacterial DnaB helicase.
Autorzy :
Malär AA; Physical Chemistry, ETH Zürich, Zürich, Switzerland.
Wili N; Physical Chemistry, ETH Zürich, Zürich, Switzerland.
Völker LA; Physical Chemistry, ETH Zürich, Zürich, Switzerland.
Kozlova MI; Department of Physics, Osnabrück University, Osnabrück, Germany.
Cadalbert R; Physical Chemistry, ETH Zürich, Zürich, Switzerland.
Däpp A; Physical Chemistry, ETH Zürich, Zürich, Switzerland.
Weber ME; Physical Chemistry, ETH Zürich, Zürich, Switzerland.
Zehnder J; Physical Chemistry, ETH Zürich, Zürich, Switzerland.
Jeschke G; Physical Chemistry, ETH Zürich, Zürich, Switzerland.
Eckert H; Institut für Physikalische Chemie, WWU Münster, Münster, Germany.; Instituto de Física de Sao Carlos, Universidade de Sao Paulo, Sao Carlos, SP, Brazil.
Böckmann A; Molecular Microbiology and Structural Biochemistry UMR 5086 CNRS/Université de Lyon, Lyon, France.
Klose D; Physical Chemistry, ETH Zürich, Zürich, Switzerland. .
Mulkidjanian AY; Department of Physics, Osnabrück University, Osnabrück, Germany. .; School of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia. .
Meier BH; Physical Chemistry, ETH Zürich, Zürich, Switzerland. .
Wiegand T; Physical Chemistry, ETH Zürich, Zürich, Switzerland. .; Max-Planck-Institute for Chemical Energy Conversion, Mülheim an der Ruhr, Germany. .; Institute of Technical and Macromolecular Chemistry, RWTH Aachen, Aachen, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 06; Vol. 12 (1), pp. 5293. Date of Electronic Publication: 2021 Sep 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Diphosphate/*chemistry
Adenosine Triphosphate/*chemistry
Bacterial Proteins/*chemistry
DNA, Bacterial/*chemistry
DnaB Helicases/*chemistry
Helicobacter pylori/*enzymology
Adenosine Diphosphate/metabolism ; Adenosine Triphosphate/metabolism ; Aluminum Compounds/chemistry ; Aluminum Compounds/metabolism ; Arginine/chemistry ; Arginine/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Catalytic Domain ; Cloning, Molecular ; DNA, Bacterial/genetics ; DNA, Bacterial/metabolism ; DnaB Helicases/genetics ; DnaB Helicases/metabolism ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Fluorides/chemistry ; Fluorides/metabolism ; Gene Expression ; Helicobacter pylori/genetics ; Hydrolysis ; Lysine/chemistry ; Lysine/metabolism ; Models, Molecular ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Substrate Specificity ; Thermodynamics
Czasopismo naukowe
Tytuł :
Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism.
Autorzy :
Maben Z; Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Arya R; Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Georgiadis D; Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece.
Stratikos E; Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece.
Stern LJ; Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 06; Vol. 12 (1), pp. 5302. Date of Electronic Publication: 2021 Sep 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Molecular Dynamics Simulation*
Polymorphism, Genetic*
Aminopeptidases/*chemistry
Minor Histocompatibility Antigens/*chemistry
Allosteric Site ; Aminopeptidases/genetics ; Aminopeptidases/metabolism ; Antigen Presentation/genetics ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; Catalytic Domain ; Cloning, Molecular ; Crystallography, X-Ray ; Endoplasmic Reticulum/genetics ; Endoplasmic Reticulum/immunology ; Gene Expression ; Humans ; Minor Histocompatibility Antigens/genetics ; Minor Histocompatibility Antigens/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Solutions
Czasopismo naukowe
Tytuł :
Binding of regulatory proteins to nucleosomes is modulated by dynamic histone tails.
Autorzy :
Peng Y; National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD, USA.
Li S; Department of Pathology and Molecular Medicine, School of Medicine, Queen's University, Kingston, ON, Canada.
Onufriev A; Physics Department, Virginia Tech, VA, USA.; Computer Science Department, Virginia Tech, VA, USA.; Center for Soft Matter and Biological Physics, Virginia Tech, VA, USA.
Landsman D; National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD, USA.
Panchenko AR; Department of Pathology and Molecular Medicine, School of Medicine, Queen's University, Kingston, ON, Canada. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 06; Vol. 12 (1), pp. 5280. Date of Electronic Publication: 2021 Sep 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Processing, Post-Translational*
DNA/*chemistry
Histones/*chemistry
Nucleosomes/*ultrastructure
Proto-Oncogene Proteins p21(ras)/*chemistry
Animals ; Binding Sites ; DNA/genetics ; DNA/metabolism ; Genome, Human ; Histones/genetics ; Histones/metabolism ; Humans ; Molecular Dynamics Simulation ; Nucleic Acid Conformation ; Nucleosomes/genetics ; Nucleosomes/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Static Electricity ; Transcription, Genetic ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Broad betacoronavirus neutralization by a stem helix-specific human antibody.
Autorzy :
Pinto D; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Sauer MM; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Czudnochowski N; Vir Biotechnology, San Francisco, CA 94158, USA.
Low JS; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Tortorici MA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Housley MP; Vir Biotechnology, San Francisco, CA 94158, USA.
Noack J; Vir Biotechnology, San Francisco, CA 94158, USA.
Walls AC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Bowen JE; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Guarino B; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Rosen LE; Vir Biotechnology, San Francisco, CA 94158, USA.
di Iulio J; Vir Biotechnology, San Francisco, CA 94158, USA.
Jerak J; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Kaiser H; Vir Biotechnology, San Francisco, CA 94158, USA.
Islam S; Vir Biotechnology, San Francisco, CA 94158, USA.
Jaconi S; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Sprugasci N; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Culap K; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Abdelnabi R; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, 3000 Leuven, Belgium.
Foo C; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, 3000 Leuven, Belgium.
Coelmont L; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, 3000 Leuven, Belgium.
Bartha I; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Bianchi S; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Silacci-Fregni C; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Bassi J; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Marzi R; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Vetti E; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Cassotta A; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Ceschi A; Clinical Trial Unit, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland.; Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland.; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, 8091 Zurich, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera italiana, 6900 Lugano, Switzerland.
Ferrari P; Faculty of Biomedical Sciences, Università della Svizzera italiana, 6900 Lugano, Switzerland.; Department of Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.; Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
Cippà PE; Department of Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.; Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland.
Giannini O; Faculty of Biomedical Sciences, Università della Svizzera italiana, 6900 Lugano, Switzerland.; Department of Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.
Ceruti S; Intensive Care Unit, Clinica Luganese Moncucco, 6900 Lugano, Switzerland.
Garzoni C; Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, 6900 Lugano, Switzerland.
Riva A; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, 20157 Milan, Italy.
Benigni F; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Cameroni E; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Piccoli L; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Pizzuto MS; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Smithey M; Vir Biotechnology, San Francisco, CA 94158, USA.
Hong D; Vir Biotechnology, San Francisco, CA 94158, USA.
Telenti A; Vir Biotechnology, San Francisco, CA 94158, USA.
Lempp FA; Vir Biotechnology, San Francisco, CA 94158, USA.
Neyts J; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, 3000 Leuven, Belgium.
Havenar-Daughton C; Vir Biotechnology, San Francisco, CA 94158, USA.
Lanzavecchia A; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Sallusto F; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.; Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland.
Snell G; Vir Biotechnology, San Francisco, CA 94158, USA.
Virgin HW; Vir Biotechnology, San Francisco, CA 94158, USA.; UT Southwestern Medical Center, Dallas, TX 75390, USA.; Washington University School of Medicine, St. Louis, MO 63110, USA.
Beltramello M; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Corti D; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
Veesler D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Sep 03; Vol. 373 (6559), pp. 1109-1116. Date of Electronic Publication: 2021 Aug 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Internalization*
Antibodies, Monoclonal/*immunology
Antibodies, Neutralizing/*immunology
Betacoronavirus/*immunology
Spike Glycoprotein, Coronavirus/*chemistry
Spike Glycoprotein, Coronavirus/*immunology
Viral Vaccines/*immunology
Animals ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Neutralizing/isolation & purification ; Convalescence ; Cricetinae ; Cross Reactions ; Humans ; Immunoglobulin Fab Fragments/immunology ; Immunoglobulin Fc Fragments/immunology ; Jurkat Cells ; Lung/immunology ; Membrane Fusion/immunology ; Neutralization Tests ; Peptide Mapping ; Protein Conformation, alpha-Helical ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Viral Load/immunology
Czasopismo naukowe

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