Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Protein Domains"" wg kryterium: Temat


Tytuł :
A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding.
Autorzy :
Sun X; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
Dyson HJ; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
Wright PE; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037 .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 05; Vol. 118 (1). Date of Electronic Publication: 2020 Dec 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Proline-Rich Protein Domains*
DNA-Binding Proteins/*chemistry
Tumor Suppressor Protein p53/*chemistry
Binding Sites ; DNA/chemistry ; DNA-Binding Proteins/genetics ; Dimerization ; Fluorescence Polarization ; Gene Expression ; Magnetic Resonance Spectroscopy ; Mutation ; Phosphorylation ; Protein Binding ; Protein Domains ; Protein Processing, Post-Translational ; Recombinant Proteins ; Sequence Deletion ; Spectrometry, Fluorescence ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
Protein-DNA complex structure modeling based on structural template.
Autorzy :
Xie J; School of Physics, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China.
Zheng J; School of Physics, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China.
Hong X; School of Physics, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China.
Tong X; School of Physics, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China.
Liu X; School of Physics, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China.
Song Q; Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, China.
Liu S; Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, China.
Liu S; School of Physics, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China. Electronic address: .
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Nov 05; Vol. 577, pp. 152-157. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Molecular*
Nucleic Acid Conformation*
Protein Domains*
Computational Biology/*methods
DNA/*chemistry
Proteins/*chemistry
DNA/genetics ; DNA/metabolism ; Protein Binding ; Proteins/metabolism ; Reproducibility of Results ; Sequence Alignment/methods
Czasopismo naukowe
Tytuł :
The Distinct Properties of the Consecutive Disordered Regions Inside or Outside Protein Domains and Their Functional Significance.
Autorzy :
Wang H; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Zhong H; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Gao C; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Zang J; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Yang D; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 01; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 01.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Domains*
Protein Interaction Domains and Motifs*
Intrinsically Disordered Proteins/*chemistry
Intrinsically Disordered Proteins/*metabolism
Amino Acid Sequence ; Chemical Phenomena ; Gene Expression ; Humans ; Intrinsically Disordered Proteins/genetics ; Protein Binding ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Trop2 Forms a Stable Dimer with Significant Structural Differences within the Membrane-Distal Region as Compared to EpCAM.
Autorzy :
Pavšič M; Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna Pot 113, SI-1000 Ljubljana, Slovenia.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 30; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Domains*
Protein Multimerization*
Antigens, Neoplasm/*chemistry
Cell Adhesion Molecules/*chemistry
Cell Membrane/*chemistry
Epithelial Cell Adhesion Molecule/*chemistry
Amino Acid Sequence ; Antigens, Neoplasm/metabolism ; Cell Adhesion Molecules/metabolism ; Cell Membrane/metabolism ; Cell Proliferation ; Claudins/metabolism ; Crystallization ; Epithelial Cell Adhesion Molecule/metabolism ; Humans ; Ligands ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Proteolysis ; Signal Transduction
Czasopismo naukowe
Tytuł :
Characterization of the NiRAN domain from RNA-dependent RNA polymerase provides insights into a potential therapeutic target against SARS-CoV-2.
Autorzy :
Dwivedy A; National Institute of Immunology, New Delhi, India.
Mariadasse R; Department of Bioinformatics, Alagappa University, Tamil Nadu, India.
Ahmad M; National Institute of Immunology, New Delhi, India.
Chakraborty S; National Institute of Immunology, New Delhi, India.
Kar D; National Institute of Immunology, New Delhi, India.
Tiwari S; National Institute of Immunology, New Delhi, India.
Bhattacharyya S; Translational Health Science and Technology Institute, Faridabad, India.
Sonar S; Translational Health Science and Technology Institute, Faridabad, India.
Mani S; Translational Health Science and Technology Institute, Faridabad, India.
Tailor P; National Institute of Immunology, New Delhi, India.
Majumdar T; National Institute of Immunology, New Delhi, India.
Jeyakanthan J; Department of Bioinformatics, Alagappa University, Tamil Nadu, India.
Biswal BK; National Institute of Immunology, New Delhi, India.
Pokaż więcej
Źródło :
PLoS computational biology [PLoS Comput Biol] 2021 Sep 13; Vol. 17 (9), pp. e1009384. Date of Electronic Publication: 2021 Sep 13 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Domains*
Antiviral Agents/*pharmacology
Coronavirus RNA-Dependent RNA Polymerase/*antagonists & inhibitors
SARS-CoV-2/*drug effects
Catalytic Domain ; Computer Simulation ; Coronavirus RNA-Dependent RNA Polymerase/chemistry ; Coronavirus RNA-Dependent RNA Polymerase/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Histone and DNA binding ability studies of the NSD subfamily of PWWP domains.
Autorzy :
Zhang M; College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Yang Y; College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Zhou M; Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei, China; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
Dong A; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
Yan X; College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Loppnau P; Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei, China.
Min J; Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei, China; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada. Electronic address: .
Liu Y; College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China. Electronic address: .
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Sep 10; Vol. 569, pp. 199-206. Date of Electronic Publication: 2021 Jul 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Domains*
DNA/*metabolism
Histone-Lysine N-Methyltransferase/*metabolism
Histones/*metabolism
Nuclear Proteins/*metabolism
Repressor Proteins/*metabolism
Amino Acid Sequence ; Base Sequence ; Binding Sites/genetics ; Crystallography, X-Ray ; DNA/chemistry ; DNA/genetics ; Histone-Lysine N-Methyltransferase/chemistry ; Histone-Lysine N-Methyltransferase/genetics ; Histones/chemistry ; Humans ; Lysine/chemistry ; Lysine/metabolism ; Methylation ; Models, Molecular ; Nuclear Proteins/chemistry ; Nuclear Proteins/genetics ; Nucleic Acid Conformation ; Protein Binding ; Repressor Proteins/chemistry ; Repressor Proteins/genetics ; Sequence Homology, Amino Acid
Czasopismo naukowe
Tytuł :
NMPylation and de-NMPylation of SARS-CoV-2 nsp9 by the NiRAN domain.
Autorzy :
Wang B; Department of Microbiology, The Ohio State University, Columbus, OH 43210, USA.; The Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
Svetlov D; Svetlov Scientific Software, Pasadena, CA 91106, USA.
Artsimovitch I; Department of Microbiology, The Ohio State University, Columbus, OH 43210, USA.; The Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
Pokaż więcej
Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Sep 07; Vol. 49 (15), pp. 8822-8835.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Protein Domains*
Nidovirales/*enzymology
Nucleotides/*metabolism
RNA-Binding Proteins/*chemistry
RNA-Binding Proteins/*metabolism
RNA-Dependent RNA Polymerase/*chemistry
RNA-Dependent RNA Polymerase/*metabolism
SARS-CoV-2/*enzymology
Viral Nonstructural Proteins/*chemistry
Viral Nonstructural Proteins/*metabolism
Amino Acid Sequence ; Catalytic Domain ; Coenzymes/metabolism ; Coronavirus RNA-Dependent RNA Polymerase/metabolism ; Diphosphates/pharmacology ; Diphosphonates/pharmacology ; Guanosine Triphosphate/metabolism ; Manganese ; Models, Molecular ; Nidovirales/chemistry ; RNA-Dependent RNA Polymerase/antagonists & inhibitors ; Uridine Triphosphate/metabolism
Czasopismo naukowe
Tytuł :
IsAb: a computational protocol for antibody design.
Autorzy :
Liang T; School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Chen H; School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Yuan J; School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Jiang C; School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Hao Y; School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Wang Y; School of Pharmacy and Bioengineering, Chongqing University of Technology, Pittsburgh, PA 15261, USA.
Feng Z; School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Xie XQ; Computational Drug Abuse Research and Computational Chemogenomics Screening Center at the University of Pittsburgh, Pittsburgh, PA 15261, USA.
Pokaż więcej
Źródło :
Briefings in bioinformatics [Brief Bioinform] 2021 Sep 02; Vol. 22 (5).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Computer-Aided Design*
Molecular Docking Simulation*
Protein Domains*
Antibodies/*chemistry
Antigen-Antibody Complex/*chemistry
Computational Biology/*methods
Animals ; Antibodies/metabolism ; Antibodies, Monoclonal, Humanized/chemistry ; Antibodies, Monoclonal, Humanized/metabolism ; Antibody Specificity ; Antigen-Antibody Complex/metabolism ; Binding Sites, Antibody ; Computer Simulation ; Crystallography, X-Ray ; Humans ; Programmed Cell Death 1 Receptor/chemistry ; Programmed Cell Death 1 Receptor/immunology ; Programmed Cell Death 1 Receptor/metabolism ; Protein Binding
Czasopismo naukowe
Tytuł :
Expanding the binding specificity for RNA recognition by a PUF domain.
Autorzy :
Zhou W; Department of Genome Sciences, University of Washington, Seattle, Washington, USA.; Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, USA.; The Rockefeller University, New York, NY, USA.
Melamed D; Department of Genome Sciences, University of Washington, Seattle, Washington, USA.; Department of Evolutionary and Environmental Biology, University of Haifa, Haifa, Israel.; Institute of Evolution, University of Haifa, Haifa, Israel.
Banyai G; The Rockefeller University, New York, NY, USA.
Meyer C; The Rockefeller University, New York, NY, USA.
Tuschl T; The Rockefeller University, New York, NY, USA.
Wickens M; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Cao J; The Rockefeller University, New York, NY, USA. .
Fields S; Department of Genome Sciences, University of Washington, Seattle, Washington, USA. .; Department of Medicine, University of Washington, Seattle, Washington, USA. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 Aug 24; Vol. 12 (1), pp. 5107. Date of Electronic Publication: 2021 Aug 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Protein Binding*
Protein Domains*
RNA/*metabolism
RNA-Binding Proteins/*metabolism
Binding Sites ; Crystallography, X-Ray ; Models, Molecular ; Protein Conformation ; RNA/chemistry ; RNA-Binding Motifs ; RNA-Binding Proteins/chemistry ; Saccharomyces cerevisiae/metabolism
Czasopismo naukowe
Tytuł :
Conformational plasticity of the ULK3 kinase domain.
Autorzy :
Mathea S; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, 60438 Frankfurt, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Goethe-University Frankfurt, 60438 Frankfurt, Germany.
Salah E; Structural Genomics Consortium (SGC), Nuffield Department of Medicine, University of Oxford, Oxford OX37DQ, U.K.; Target Discovery Institute (TDI), Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX37FZ, U.K.
Tallant C; Structural Genomics Consortium (SGC), Nuffield Department of Medicine, University of Oxford, Oxford OX37DQ, U.K.; Target Discovery Institute (TDI), Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX37FZ, U.K.
Chatterjee D; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, 60438 Frankfurt, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Goethe-University Frankfurt, 60438 Frankfurt, Germany.
Berger BT; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, 60438 Frankfurt, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Goethe-University Frankfurt, 60438 Frankfurt, Germany.
Konietzny R; Target Discovery Institute (TDI), Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX37FZ, U.K.
Müller S; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Goethe-University Frankfurt, 60438 Frankfurt, Germany.
Kessler BM; Target Discovery Institute (TDI), Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX37FZ, U.K.
Knapp S; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, 60438 Frankfurt, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Goethe-University Frankfurt, 60438 Frankfurt, Germany.; German Cancer Network (DKTK), Frankfurt/Mainz, 60438 Frankfurt, Germany.
Pokaż więcej
Źródło :
The Biochemical journal [Biochem J] 2021 Jul 30; Vol. 478 (14), pp. 2811-2823.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Catalytic Domain*
Protein Conformation*
Protein Domains*
Protein-Serine-Threonine Kinases/*chemistry
Aniline Compounds/metabolism ; Aniline Compounds/pharmacology ; Benzamides/metabolism ; Benzamides/pharmacology ; Biocatalysis/drug effects ; Humans ; Models, Molecular ; Nitriles/metabolism ; Nitriles/pharmacology ; Oncogene Proteins/chemistry ; Oncogene Proteins/metabolism ; Protein Binding ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Pyrimidines/metabolism ; Pyrimidines/pharmacology ; Quinolines/metabolism ; Quinolines/pharmacology ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Substrate Specificity
Czasopismo naukowe
Tytuł :
The intramolecular allostery of GRB2 governing its interaction with SOS1 is modulated by phosphotyrosine ligands.
Autorzy :
Kazemein Jasemi NS; Institute of Biochemistry and Molecular Biology II, Medical Faculty of the Heinrich-Heine University, 40225 Düsseldorf, Germany.
Herrmann C; Department of Physical Chemistry I, Ruhr University Bochum, Bochum, Germany.
Magdalena Estirado E; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, 5600MB Eindhoven, The Netherlands.
Gremer L; Institute of Physical Biology, Heinrich Heine University Düsseldorf, 40204 Düsseldorf, Germany.; Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, Germany.
Willbold D; Institute of Physical Biology, Heinrich Heine University Düsseldorf, 40204 Düsseldorf, Germany.; Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, Germany.
Brunsveld L; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, 5600MB Eindhoven, The Netherlands.
Dvorsky R; Institute of Biochemistry and Molecular Biology II, Medical Faculty of the Heinrich-Heine University, 40225 Düsseldorf, Germany.
Ahmadian MR; Institute of Biochemistry and Molecular Biology II, Medical Faculty of the Heinrich-Heine University, 40225 Düsseldorf, Germany.
Pokaż więcej
Źródło :
The Biochemical journal [Biochem J] 2021 Jul 30; Vol. 478 (14), pp. 2793-2809.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Domains*
src Homology Domains*
GRB2 Adaptor Protein/*chemistry
Phosphotyrosine/*chemistry
SOS1 Protein/*chemistry
Amino Acid Sequence ; Binding Sites/genetics ; GRB2 Adaptor Protein/genetics ; GRB2 Adaptor Protein/metabolism ; Humans ; Kinetics ; Ligands ; Models, Molecular ; Phosphotyrosine/metabolism ; Protein Binding ; SOS1 Protein/genetics ; SOS1 Protein/metabolism
Czasopismo naukowe
Tytuł :
Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif.
Autorzy :
Ultsch M; Department of Structural Biology, Genentech Inc., South San Francisco, CA, USA.
Holliday MJ; Department of Early Discovery Biochemistry, Genentech Inc., South San Francisco, CA, USA.
Gerhardy S; Department of Early Discovery Biochemistry, Genentech Inc., South San Francisco, CA, USA.
Moran P; Department of Early Discovery Biochemistry, Genentech Inc., South San Francisco, CA, USA.
Scales SJ; Department of Immunology, Genentech Inc., South San Francisco, CA, USA.
Gupta N; Department of Immunology, Genentech Inc., South San Francisco, CA, USA.
Oltrabella F; Department of Immunology, Genentech Inc., South San Francisco, CA, USA.
Chiu C; Department of Antibody Engineering, Genentech Inc., South San Francisco, CA, USA.
Fairbrother W; Department of Early Discovery Biochemistry, Genentech Inc., South San Francisco, CA, USA.
Eigenbrot C; Department of Structural Biology, Genentech Inc., South San Francisco, CA, USA.
Kirchhofer D; Department of Early Discovery Biochemistry, Genentech Inc., South San Francisco, CA, USA. .
Pokaż więcej
Źródło :
Communications biology [Commun Biol] 2021 Jul 27; Vol. 4 (1), pp. 916. Date of Electronic Publication: 2021 Jul 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Protein Domains*
Apolipoprotein L1/*chemistry
Apolipoproteins L/*chemistry
Apolipoprotein L1/genetics ; Apolipoprotein L1/metabolism ; Apolipoproteins L/genetics ; Apolipoproteins L/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Syndecan Transmembrane Domain Specifically Regulates Downstream Signaling Events of the Transmembrane Receptor Cytoplasmic Domain.
Autorzy :
Hwang J; Department of Life Sciences, Ewha Womans University, Seoul 03760, Korea.
Jang B; Department of Life Sciences, Ewha Womans University, Seoul 03760, Korea.
Kim A; Department of Life Sciences, Ewha Womans University, Seoul 03760, Korea.
Lee Y; Department of Life Sciences, Ewha Womans University, Seoul 03760, Korea.
Lee J; Department of Life Sciences, Korea University, Seoul 02841, Korea.
Kim C; Department of Life Sciences, Korea University, Seoul 02841, Korea.
Kim J; Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.
Moon KM; Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.
Kim K; Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.
Wagle R; Department of Biomedical Gerontology, Ilsong Institute of Life Science, Hallym University, Anyang-si 14066, Korea.
Song YH; Department of Biomedical Gerontology, Ilsong Institute of Life Science, Hallym University, Anyang-si 14066, Korea.
Oh ES; Department of Life Sciences, Ewha Womans University, Seoul 03760, Korea.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 24; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 24.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Adhesion*
Protein Domains*
Signal Transduction*
Syndecan-2/*metabolism
Animals ; HEK293 Cells ; Humans ; Mice ; NIH 3T3 Cells ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Protein Multimerization ; Protein Processing, Post-Translational ; Syndecan-2/physiology ; src-Family Kinases/metabolism
Czasopismo naukowe
Tytuł :
dSPRINT: predicting DNA, RNA, ion, peptide and small molecule interaction sites within protein domains.
Autorzy :
Etzion-Fuchs A; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Carl Icahn Laboratory, Princeton, NJ 08544, USA.
Todd DA; Department of Computer Science, Princeton University, 35 Olden Street, Princeton, NJ 08544, USA.
Singh M; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Carl Icahn Laboratory, Princeton, NJ 08544, USA.; Department of Computer Science, Princeton University, 35 Olden Street, Princeton, NJ 08544, USA.
Pokaż więcej
Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 21; Vol. 49 (13), pp. e78.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Machine Learning*
Protein Domains*
Binding Sites ; DNA/metabolism ; Humans ; Ions/metabolism ; Ligands ; Peptides/metabolism ; RNA/metabolism
Czasopismo naukowe
Tytuł :
TopDomain: Exhaustive Protein Domain Boundary Metaprediction Combining Multisource Information and Deep Learning.
Autorzy :
Mulnaes D; Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.
Golchin P; Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.
Koenig F; Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.
Gohlke H; Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.; John von Neumann Institute for Computing (NIC), Jülich Supercomputing Centre (JSC), Institute of Biological Information Processing (IBI-7: Structural Biochemistry) & Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.
Pokaż więcej
Źródło :
Journal of chemical theory and computation [J Chem Theory Comput] 2021 Jul 13; Vol. 17 (7), pp. 4599-4613. Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article
MeSH Terms :
Deep Learning*
Protein Domains*
Algorithms ; Computational Biology/methods ; Protein Conformation ; Proteins/chemistry
Czasopismo naukowe
Tytuł :
DoChaP: the domain change presenter.
Autorzy :
Gal-Oz ST; Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Haiat N; Department of Software and Information Systems Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Eliyahu D; Department of Software and Information Systems Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Shani G; Department of Software and Information Systems Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Shay T; Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.; Department of Software and Information Systems Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Pokaż więcej
Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 02; Vol. 49 (W1), pp. W162-W168.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Exons*
Protein Domains*
Software*
Animals ; Genomics ; Humans ; Mice ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Rats ; Xenopus Proteins/chemistry ; Zebrafish Proteins/chemistry
Czasopismo naukowe
Tytuł :
MyCLADE: a multi-source domain annotation server for sequence functional exploration.
Autorzy :
Vicedomini R; Sorbonne Université, CNRS, IBPS, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), UMR 7238, Paris 75005, France.; Sorbonne Université, CNRS, Institut des Sciences du Calcul et des Données (ISCD), France.
Blachon C; Sorbonne Université, CNRS, IBPS, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), UMR 7238, Paris 75005, France.
Oteri F; Sorbonne Université, CNRS, IBPS, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), UMR 7238, Paris 75005, France.
Carbone A; Sorbonne Université, CNRS, IBPS, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), UMR 7238, Paris 75005, France.
Pokaż więcej
Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 02; Vol. 49 (W1), pp. W452-W458.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Sequence Annotation*
Protein Domains*
Software*
Genomics ; Metagenomics ; Sequence Analysis, Protein/methods ; Staphylococcus aureus/genetics
Czasopismo naukowe
Tytuł :
DomainViz: intuitive visualization of consensus domain distributions across groups of proteins.
Autorzy :
Schläpfer P; Institute for Molecular Plant Biology, D-BIOL, ETH Zurich, Zürich 8092, Switzerland.
Mehta D; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.
Ridderikhoff C; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.
Uhrig RG; Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.
Pokaż więcej
Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 02; Vol. 49 (W1), pp. W169-W173.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Domains*
Software*
Amino Acid Sequence ; Conserved Sequence ; Databases, Protein ; Sequence Analysis, Protein
Czasopismo naukowe
Tytuł :
Zinc-binding domain mediates pleiotropic functions of Yvh1 in Cryptococcus neoformans.
Autorzy :
Jin JH; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
Choi MK; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
Cho HS; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
Bahn YS; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea. .
Pokaż więcej
Źródło :
Journal of microbiology (Seoul, Korea) [J Microbiol] 2021 Jul; Vol. 59 (7), pp. 658-665. Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Domains*
Cryptococcus neoformans/*enzymology
Dual-Specificity Phosphatases/*chemistry
Dual-Specificity Phosphatases/*metabolism
Zinc/*metabolism
Catalytic Domain ; Cryptococcus neoformans/cytology ; Cryptococcus neoformans/genetics ; Cryptococcus neoformans/pathogenicity ; Fungal Proteins/chemistry ; Fungal Proteins/metabolism ; Genetic Complementation Test ; Melanins/biosynthesis ; Mutation ; Protein Binding ; Urease/biosynthesis ; Virulence Factors/biosynthesis ; Zinc Fingers
Czasopismo naukowe
Tytuł :
Structural Basis of DEPTOR to Recognize Phosphatidic Acid Using its Tandem DEP Domains.
Autorzy :
Weng Z; School of Medicine, Sun Yat-Sen University, Guangzhou 510275, China.
Shen X; School of Medicine, Sun Yat-Sen University, Guangzhou 510275, China.
Zheng J; School of Medicine, Sun Yat-Sen University, Guangzhou 510275, China.
Liang H; Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou 510275, China. Electronic address: .
Liu Y; School of Medicine, Sun Yat-Sen University, Guangzhou 510275, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Guangzhou 510275, China. Electronic address: .
Pokaż więcej
Źródło :
Journal of molecular biology [J Mol Biol] 2021 Jun 25; Vol. 433 (13), pp. 166989. Date of Electronic Publication: 2021 Apr 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Domains*
Repetitive Sequences, Amino Acid*
Intracellular Signaling Peptides and Proteins/*chemistry
Phosphatidic Acids/*chemistry
Amino Acid Motifs/genetics ; Amino Acid Sequence ; Crystallography, X-Ray ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Mechanistic Target of Rapamycin Complex 1/chemistry ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Models, Molecular ; Mutation ; Phosphatidic Acids/metabolism ; Protein Binding ; Sequence Homology, Amino Acid ; Signal Transduction/genetics ; TOR Serine-Threonine Kinases/chemistry ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies