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Wyszukujesz frazę ""Protein Domains"" wg kryterium: Temat


Tytuł:
Laminin fragments conjugated with perlecan's growth factor-binding domain differentiate human induced pluripotent stem cells into skin-derived precursor cells.
Autorzy:
Sugiyama-Nakagiri Y; Kao Corporation, 2602, Akabane Ichikai-Machi, Haga-gun, Tochigi, 321-3497, Japan. .
Yamashita S; Kao Corporation, 2602, Akabane Ichikai-Machi, Haga-gun, Tochigi, 321-3497, Japan.
Taniguchi Y; Division of Matrixome Research and Application, Institute for Protein Research, Osaka University, Suita, Osaka, Japan.
Shimono C; Division of Matrixome Research and Application, Institute for Protein Research, Osaka University, Suita, Osaka, Japan.
Sekiguchi K; Division of Matrixome Research and Application, Institute for Protein Research, Osaka University, Suita, Osaka, Japan. sekiguch@protein.osaka-u.ac.jp.
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 04; Vol. 13 (1), pp. 14556. Date of Electronic Publication: 2023 Sep 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Differentiation*/drug effects
Heparan Sulfate Proteoglycans*/chemistry
Induced Pluripotent Stem Cells*/cytology
Induced Pluripotent Stem Cells*/drug effects
Intercellular Signaling Peptides and Proteins*/metabolism
Laminin*/chemistry
Laminin*/pharmacology
Peptide Fragments*/chemistry
Peptide Fragments*/pharmacology
Protein Domains*
Skin*/cytology
Humans ; Adipocytes/cytology ; Adipocytes/drug effects ; Osteocytes/cytology ; Osteocytes/drug effects ; Schwann Cells/cytology ; Schwann Cells/drug effects ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/pharmacology
Czasopismo naukowe
Tytuł:
Optimizing strategy for the discovery of compositionally-biased or low-complexity regions in proteins.
Autorzy:
Harrison PM; Department of Biology, McGill University, Montreal, QC, Canada. .
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Źródło:
Scientific reports [Sci Rep] 2024 Jan 05; Vol. 14 (1), pp. 680. Date of Electronic Publication: 2024 Jan 05.
Typ publikacji:
Journal Article
MeSH Terms:
Intrinsically Disordered Proteins*
Antifibrinolytic Agents*
Humans ; Amino Acids ; Amino Acid Sequence ; Protein Domains
Czasopismo naukowe
Tytuł:
Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal.
Autorzy:
Pearson M; Department of Infectious Disease, Imperial College London, London, W12 0NN, UK.; Centre for Bacterial Resistance Biology, Imperial College London, London, SW7 2AZ, UK.
Haslam C; GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
Fosberry A; GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
Jones EJ; GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
Reglinski M; Department of Infectious Disease, Imperial College London, London, W12 0NN, UK.
Reeves L; Department of Infectious Disease, Imperial College London, London, W12 0NN, UK.
Edwards RJ; Department of Medicine, Imperial College London, London, W12 0NN, UK.
Lawrenson RA; Department of Infectious Disease, Imperial College London, London, W12 0NN, UK.
Brown JC; Department of Infectious Disease, Imperial College London, London, W12 0NN, UK.
Mossakowska D; GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.; Malopolska Centre of Biotechnology, Jagiellonian University, 30-387, Kraków, Poland.
Pease JE; National Heart and Lung Institute, Imperial College London, London, SW7 2AZ, UK. .
Sriskandan S; Department of Infectious Disease, Imperial College London, London, W12 0NN, UK. .; Centre for Bacterial Resistance Biology, Imperial College London, London, SW7 2AZ, UK. .
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 03; Vol. 13 (1), pp. 19052. Date of Electronic Publication: 2023 Nov 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Streptococcus pyogenes*/metabolism
Peptide Hydrolases*/metabolism
Protein Domains
Czasopismo naukowe
Tytuł:
The role of an amphiphilic helix and transmembrane region in the efficient acylation of the M2 protein from influenza virus.
Autorzy:
Meng X; Institute of Virology, Veterinary Faculty, Freie Universität Berlin, Berlin, Germany.
Templeton C; Theoretical and Computational Biophysics, Department of Physics, Freie Universität Berlin, Berlin, Germany.
Clementi C; Theoretical and Computational Biophysics, Department of Physics, Freie Universität Berlin, Berlin, Germany.
Veit M; Institute of Virology, Veterinary Faculty, Freie Universität Berlin, Berlin, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 02; Vol. 13 (1), pp. 18928. Date of Electronic Publication: 2023 Nov 02.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
MeSH Terms:
Influenza A virus*/physiology
Orthomyxoviridae*
Humans ; Protein Domains ; Fatty Acids/metabolism ; Acylation
Czasopismo naukowe
Tytuł:
Tracing the birth of structural domains from loops during protein evolution.
Autorzy:
Aziz MF; Evolutionary Bioinformatics Laboratory, Department of Crop Sciences, University of Illinois, Urbana, IL, 61801, USA.
Mughal F; Evolutionary Bioinformatics Laboratory, Department of Crop Sciences, University of Illinois, Urbana, IL, 61801, USA.
Caetano-Anollés G; Evolutionary Bioinformatics Laboratory, Department of Crop Sciences, University of Illinois, Urbana, IL, 61801, USA. .; C.R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL, 61801, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 06; Vol. 13 (1), pp. 14688. Date of Electronic Publication: 2023 Sep 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Dermatitis*
Humans ; Embryonic Development ; Phylogeny ; Protein Domains ; Translations
Czasopismo naukowe
Tytuł:
A novel binding site between the voltage-dependent calcium channel Ca V 1.2 subunit and Ca V β2 subunit discovered using a new analysis method for protein-protein interactions.
Autorzy:
Murakami AM; Department of Pharmacology, Hirosaki University Graduate School of Medicine, 5 Zaifucho, Hirosaki, 036-8562, Japan.
Nagatomo K; Department of Pharmacology, Hirosaki University Graduate School of Medicine, 5 Zaifucho, Hirosaki, 036-8562, Japan.
Miyoshi I; Department of Laboratory Animal Medicine, Tohoku University School of Medicine, 2-1 Seiryo-Machi, Aoba-ku, Sendai, 980-8575, Japan.
Itagaki S; Collaboration Center for Community and Industry, Sapporo Medical University, S1 W17, Chuo-ku, Sapporo, 060-8556, Japan.
Niwa Y; Department of Pharmacology, Hirosaki University Graduate School of Medicine, 5 Zaifucho, Hirosaki, 036-8562, Japan.
Murakami M; Department of Pharmacology, Hirosaki University Graduate School of Medicine, 5 Zaifucho, Hirosaki, 036-8562, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2023 Aug 26; Vol. 13 (1), pp. 13986. Date of Electronic Publication: 2023 Aug 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium Channels*/genetics
Protein Domains ; Binding Sites ; Epitopes ; Clone Cells
Czasopismo naukowe
Tytuł:
Key role of phosphorylation sites in ATPase domain and Linker region of MLH1 for DNA binding and functionality of MutLα.
Autorzy:
Firnau MB; Goethe University Frankfurt, University Hospital, Medical Clinic 1, Biomedical Research Laboratory, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.
Plotz G; Goethe University Frankfurt, University Hospital, Medical Clinic 1, Biomedical Research Laboratory, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.
Zeuzem S; Goethe University Frankfurt, University Hospital, Medical Clinic 1, Biomedical Research Laboratory, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.
Brieger A; Goethe University Frankfurt, University Hospital, Medical Clinic 1, Biomedical Research Laboratory, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2023 Aug 02; Vol. 13 (1), pp. 12503. Date of Electronic Publication: 2023 Aug 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Mismatch Repair*
DNA*/metabolism
Humans ; Mismatch Repair Endonuclease PMS2/genetics ; Mismatch Repair Endonuclease PMS2/metabolism ; MutL Protein Homolog 1/genetics ; MutL Protein Homolog 1/metabolism ; Phosphorylation ; Protein Domains ; MutL Proteins/genetics ; MutL Proteins/metabolism
Czasopismo naukowe
Tytuł:
Pan-cancer structurome reveals overrepresentation of beta sandwiches and underrepresentation of alpha helical domains.
Autorzy:
Medvedev KE; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. .
Schaeffer RD; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Chen KS; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Grishin NV; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
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Źródło:
Scientific reports [Sci Rep] 2023 Jul 25; Vol. 13 (1), pp. 11988. Date of Electronic Publication: 2023 Jul 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Proteins*/chemistry
Neoplasms*
Humans ; Protein Domains ; Protein Conformation, alpha-Helical
Czasopismo naukowe
Tytuł:
Crystal structure of [1,2,4]triazolo[4,3-b]pyridazine derivatives as BRD4 bromodomain inhibitors and structure-activity relationship study.
Autorzy:
Kim JH; Research Institute, National Cancer Center, Goyang, Gyeonggi, 10408, Republic of Korea.; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Gyeonggi, 10408, Republic of Korea.
Pandit N; Department of Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon, 34113, Republic of Korea.
Yoo M; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
Park TH; Department of Anesthesiology, Weill Cornell Medical College, New York, NY, 10065, USA.
Choi JU; Department of Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon, 34113, Republic of Korea.; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
Park CH; Department of Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon, 34113, Republic of Korea. .; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea. .
Jung KY; Department of Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon, 34113, Republic of Korea. .; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea. .
Lee BI; Research Institute, National Cancer Center, Goyang, Gyeonggi, 10408, Republic of Korea. .; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Gyeonggi, 10408, Republic of Korea. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jul 04; Vol. 13 (1), pp. 10805. Date of Electronic Publication: 2023 Jul 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Nuclear Proteins*/metabolism
Transcription Factors*/metabolism
Cell Cycle Proteins/metabolism ; Protein Domains ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Identification of putative essential protein domains from high-density transposon insertion sequencing.
Autorzy:
Rahman ASMZ; Department of Microbiology, University of Manitoba, Winnipeg, MB, Canada.
Timmerman L; Department of Computer Science, University of Manitoba, Winnipeg, MB, Canada.
Gallardo F; Department of Microbiology, University of Manitoba, Winnipeg, MB, Canada.
Cardona ST; Department of Microbiology, University of Manitoba, Winnipeg, MB, Canada. .; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jan 19; Vol. 12 (1), pp. 962. Date of Electronic Publication: 2022 Jan 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, Essential*
Protein Domains*
Bacterial Proteins/*genetics
Burkholderia cenocepacia/*genetics
Burkholderia cenocepacia/growth & development ; Escherichia coli
Czasopismo naukowe
Tytuł:
Extension of human GCSF serum half-life by the fusion of albumin binding domain.
Autorzy:
Nikravesh FY; Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Shirkhani S; Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Bayat E; Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Talebkhan Y; Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran. .
Mirabzadeh E; Department of Molecular Medicine, Pasteur Institute of Iran, Tehran, Iran.
Sabzalinejad M; Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Aliabadi HAM; Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Nematollahi L; Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Ardakani YH; Biopharmaceutics and Pharmacokinetic Division, Department of Pharmaceutics, Faculty of Pharmacy, Tehran, Iran. .
Sardari S; Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
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Źródło:
Scientific reports [Sci Rep] 2022 Jan 13; Vol. 12 (1), pp. 667. Date of Electronic Publication: 2022 Jan 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Domains*
Albumins/*pharmacology
Cell Proliferation/*drug effects
Granulocyte Colony-Stimulating Factor/*blood
Granulocyte Colony-Stimulating Factor/*pharmacology
Albumins/chemistry ; Albumins/pharmacokinetics ; Animals ; Cell Line ; Chemical Phenomena ; Disease Models, Animal ; Escherichia coli ; Granulocyte Colony-Stimulating Factor/chemistry ; Granulocyte Colony-Stimulating Factor/pharmacokinetics ; Half-Life ; Humans ; Inclusion Bodies ; Leukocyte Count ; Neutropenia/metabolism ; Neutrophils/drug effects ; Protein Binding ; Rats
Czasopismo naukowe
Tytuł:
A coiled-coil-based design strategy for the thermostabilization of G-protein-coupled receptors.
Autorzy:
Amer M; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institute, 5232, Villigen PSI, Switzerland.
Leka O; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institute, 5232, Villigen PSI, Switzerland.
Jasko P; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institute, 5232, Villigen PSI, Switzerland.
Frey D; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institute, 5232, Villigen PSI, Switzerland.
Li X; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institute, 5232, Villigen PSI, Switzerland.
Kammerer RA; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institute, 5232, Villigen PSI, Switzerland. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jun 22; Vol. 13 (1), pp. 10159. Date of Electronic Publication: 2023 Jun 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, G-Protein-Coupled*/genetics
Amino Acid Sequence ; Protein Structure, Secondary ; Crystallography, X-Ray ; Protein Domains
Czasopismo naukowe
Tytuł:
ELV-N32 and RvD6 isomer decrease pro-inflammatory cytokines, senescence programming, ACE2 and SARS-CoV-2-spike protein RBD binding in injured cornea.
Autorzy:
Pham TL; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier St., Ste. D, New Orleans, LA, 70112-2223, USA.
He J; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier St., Ste. D, New Orleans, LA, 70112-2223, USA.
Kakazu AH; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier St., Ste. D, New Orleans, LA, 70112-2223, USA.
Calandria J; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier St., Ste. D, New Orleans, LA, 70112-2223, USA.
Do KV; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier St., Ste. D, New Orleans, LA, 70112-2223, USA.
Nshimiyimana R; Department of Chemistry and Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, CA, USA.
Lam TF; Department of Chemistry and Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, CA, USA.
Petasis NA; Department of Chemistry and Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, CA, USA.
Bazan HEP; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier St., Ste. D, New Orleans, LA, 70112-2223, USA. .
Bazan NG; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier St., Ste. D, New Orleans, LA, 70112-2223, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jun 17; Vol. 11 (1), pp. 12787. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Domains*
Angiotensin-Converting Enzyme 2/*metabolism
Cellular Senescence/*drug effects
Corneal Injuries/*metabolism
Cytokines/*metabolism
Docosahexaenoic Acids/*analogs & derivatives
Docosahexaenoic Acids/*pharmacology
Drug Discovery/*methods
Signal Transduction/*drug effects
Spike Glycoprotein, Coronavirus/*metabolism
Animals ; COVID-19/metabolism ; COVID-19/virology ; Cells, Cultured ; Disease Models, Animal ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Epithelium, Corneal/cytology ; Humans ; Lipoxins/pharmacology ; Male ; Protein Binding ; Rats ; Rats, Sprague-Dawley ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/chemistry ; Virus Attachment/drug effects ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł:
Evolution of networks of protein domain organization.
Autorzy:
Aziz MF; Evolutionary Bioinformatics Laboratory, Department of Crop Sciences, University of Illinois, Urbana, IL, 61801, USA.
Caetano-Anollés G; Evolutionary Bioinformatics Laboratory, Department of Crop Sciences, University of Illinois, Urbana, IL, 61801, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jun 08; Vol. 11 (1), pp. 12075. Date of Electronic Publication: 2021 Jun 08.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Evolution, Molecular*
Protein Domains*
Computational Biology/*methods
Archaeal Proteins/metabolism ; Bacterial Proteins/metabolism ; Calibration ; Cluster Analysis ; Eukaryotic Cells/metabolism ; Genomics ; Models, Biological ; Molecular Biology ; Phylogeny ; Protein Conformation ; Proteomics ; Regression Analysis
Czasopismo naukowe
Tytuł:
An alternative domain-swapped structure of the Pyrococcus horikoshii PolII mini-intein.
Autorzy:
Williams JE; Department of Chemistry, College of the Holy Cross, 1 College Street, Worcester, MA, USA.
Jaramillo MV; Department of Chemistry, College of the Holy Cross, 1 College Street, Worcester, MA, USA.
Li Z; Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY, 12208, USA.; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA.
Zhao J; Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.; China Agricultural University, Beijing, China.
Wang C; Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.
Li H; Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY, 12208, USA.; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA.; Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, NY, USA.
Mills KV; Department of Chemistry, College of the Holy Cross, 1 College Street, Worcester, MA, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jun 03; Vol. 11 (1), pp. 11680. Date of Electronic Publication: 2021 Jun 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Inteins*
Protein Domains*
Pyrococcus horikoshii*
Archaeal Proteins/*chemistry
Amino Acid Sequence ; Archaeal Proteins/genetics ; Archaeal Proteins/metabolism ; Gene Expression ; Models, Molecular ; Protein Conformation ; Protein Interaction Domains and Motifs
Czasopismo naukowe
Tytuł:
Phosphorylation of the WH2 domain in yeast Las17/WASP regulates G-actin binding and protein function during endocytosis.
Autorzy:
Tyler JJ; Department of Biomedical Science, Firth Court, University of Sheffield, Sheffield, S10 2TN, UK.
Smaczynska-de Rooij II; Department of Biomedical Science, Firth Court, University of Sheffield, Sheffield, S10 2TN, UK.
Abugharsa L; Department of Biomedical Science, Firth Court, University of Sheffield, Sheffield, S10 2TN, UK.
Palmer JS; Department of Biomedical Science, Firth Court, University of Sheffield, Sheffield, S10 2TN, UK.
Hancock LP; Department of Biomedical Science, Firth Court, University of Sheffield, Sheffield, S10 2TN, UK.
Allwood EG; Department of Biomedical Science, Firth Court, University of Sheffield, Sheffield, S10 2TN, UK.
Ayscough KR; Department of Biomedical Science, Firth Court, University of Sheffield, Sheffield, S10 2TN, UK. .
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Źródło:
Scientific reports [Sci Rep] 2021 May 06; Vol. 11 (1), pp. 9718. Date of Electronic Publication: 2021 May 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endocytosis*
Protein Domains*
Actins/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Wiskott-Aldrich Syndrome Protein/*metabolism
Amino Acid Sequence ; Mutation ; Phosphorylation ; Polymerization ; Protein Binding ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Sequence Homology, Amino Acid ; Wiskott-Aldrich Syndrome Protein/chemistry ; Wiskott-Aldrich Syndrome Protein/genetics
Czasopismo naukowe
Tytuł:
Identification of critical amino acid residues in the regulatory N-terminal domain of PMEL.
Autorzy:
Mitchell SM; Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT, 06519, USA.
Graham M; Department of Cell Biology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT, 06519, USA.
Liu X; Department of Cell Biology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT, 06519, USA.
Leonhardt RM; Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT, 06519, USA. .; Boehringer Ingelheim RCV GmbH & Co KG, Cancer Immunology and Immune Modulation, Dr. Boehringer Gasse 5-11, 1121, Vienna, Austria. .
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Źródło:
Scientific reports [Sci Rep] 2021 Apr 08; Vol. 11 (1), pp. 7730. Date of Electronic Publication: 2021 Apr 08.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Protein Domains*
Amino Acids/*chemistry
gp100 Melanoma Antigen/*chemistry
Amino Acid Sequence ; Endoplasmic Reticulum/metabolism ; Humans ; Melanosomes/metabolism ; Mutation ; Protein Folding ; Protein Transport ; Subcellular Fractions/metabolism ; gp100 Melanoma Antigen/metabolism
Czasopismo naukowe
Tytuł:
Structural insights into vesicle amine transport-1 (VAT-1) as a member of the NADPH-dependent quinone oxidoreductase family.
Autorzy:
Kim SY; Structural Biology Laboratory, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.
Mori T; Structural Biology Laboratory, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.
Chek MF; Structural Biology Laboratory, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.
Furuya S; Structural Biology Laboratory, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.
Matsumoto K; Department of Developmental Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo, Aoba, Sendai, Miyagi, 980-8575, Japan.
Yajima T; Department of Developmental Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo, Aoba, Sendai, Miyagi, 980-8575, Japan.
Ogura T; Department of Developmental Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo, Aoba, Sendai, Miyagi, 980-8575, Japan.
Hakoshima T; Structural Biology Laboratory, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jan 22; Vol. 11 (1), pp. 2120. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Domains*
Protein Multimerization*
NAD(P)H Dehydrogenase (Quinone)/*chemistry
Vesicular Transport Proteins/*chemistry
Binding Sites/genetics ; Biocatalysis ; Catalytic Domain ; Crystallography, X-Ray ; Humans ; Kinetics ; Models, Molecular ; NAD(P)H Dehydrogenase (Quinone)/genetics ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; NADP/chemistry ; NADP/metabolism ; Protein Binding ; Substrate Specificity ; Vesicular Transport Proteins/genetics ; Vesicular Transport Proteins/metabolism
Czasopismo naukowe
Tytuł:
Complex of human Melanotransferrin and SC57.32 Fab fragment reveals novel interdomain arrangement with ferric N-lobe and open C-lobe.
Autorzy:
Hayashi K; Research and Development, AbbVie Inc., South San Francisco, CA, 94080, USA.
Longenecker KL; Research and Development, AbbVie Inc., North Chicago, IL, 60064, USA.
Liu YL; Research and Development, AbbVie Inc., South San Francisco, CA, 94080, USA.
Faust B; Research and Development, AbbVie Inc., South San Francisco, CA, 94080, USA.
Prashar A; Research and Development, AbbVie Inc., South San Francisco, CA, 94080, USA.
Hampl J; Research and Development, AbbVie Inc., South San Francisco, CA, 94080, USA.
Stoll V; Research and Development, AbbVie Inc., North Chicago, IL, 60064, USA.
Vivona S; Research and Development, AbbVie Inc., South San Francisco, CA, 94080, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jan 12; Vol. 11 (1), pp. 566. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Domains*
Immunoglobulin Fab Fragments/*chemistry
Membrane Glycoproteins/*chemistry
Membrane Glycoproteins/*physiology
Acetylglucosamine ; Animals ; Biological Transport ; Blood-Brain Barrier/metabolism ; Drug Delivery Systems ; Drug Design ; Gene Expression ; Humans ; Immunoglobulin Fab Fragments/genetics ; Immunoglobulin Fab Fragments/metabolism ; Immunoglobulin Fab Fragments/physiology ; Iron/metabolism ; Macaca fascicularis ; Melanoma/etiology ; Melanoma/genetics ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Mice ; Protein Binding ; Triple Negative Breast Neoplasms/genetics
Czasopismo naukowe
Tytuł:
Drug-target interaction prediction based on protein features, using wrapper feature selection.
Autorzy:
Abbasi Mesrabadi H; Faculty of Computer and Information Technology Engineering, Qazvin Branch, Islamic Azad University, Qazvin, Iran.
Faez K; Department of Electrical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran. .
Pirgazi J; Department of Computer Engineering, University of Science and Technology of Mazandaran, Behshahr, Iran.
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 03; Vol. 13 (1), pp. 3594. Date of Electronic Publication: 2023 Mar 03.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Delivery Systems*
Labor, Obstetric*
Pregnancy ; Female ; Humans ; Drug Development ; Forests ; Protein Domains
Czasopismo naukowe

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