Temat: "Protein Engineering" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Tailoring FPOX enzymes for enhanced stability and expanded substrate recognition.
Autorzy:: Estiri H; Department of Biotechnology, Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, 1006, Latvia.
Bhattacharya S; Department of Biotechnology, Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, 1006, Latvia.; Faculty of Materials Science and Applied Chemistry, Riga Technical University, Paula Valdena 3, Riga, 1048, Latvia.
Buitrago JAR; Department of Biotechnology, Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, 1006, Latvia.
Castagna R; Department of Biotechnology, Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, 1006, Latvia.; Dipartimento di Chimica, Materiali e Ingegneria Chimica 'Giulio Natta', Politecnico di Milano, Piazza L. da Vinci 32, 20133, Milano, Italy.
Legzdiņa L; Department of Biotechnology, Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, 1006, Latvia.
Casucci G; Department of Biotechnology, Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, 1006, Latvia.
Ricci A; Biomolecular Engineering Lab, Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milano, Italy.
Parisini E; Department of Biotechnology, Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, 1006, Latvia. .; Department of Chemistry 'G. Ciamician', University of Bologna, Via Selmi 2, 40126, Bologna, Italy. .
Gautieri A; Biomolecular Engineering Lab, Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milano, Italy. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Oct 30; Vol. 13 (1), pp. 18610. Date of Electronic Publication: 2023 Oct 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Peptides*
Diabetes Mellitus*
Humans ; Protein Engineering ; Peptide Hydrolases ; Serum Albumin

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Skocz do pozycji: 2.

Tytuł:: A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins.
Autorzy:: Fryszkowska A; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
An C; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Alvizo O; Codexis Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA.
Banerjee G; Codexis Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA.
Canada KA; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Cao Y; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
DeMong D; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Devine PN; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Duan D; Codexis Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA.
Elgart DM; Codexis Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA.
Farasat I; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Gauthier DR; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Guidry EN; Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ 07033, USA.
Jia X; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Kong J; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Kruse N; Codexis Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA.
Lexa KW; Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ 07033, USA.
Makarov AA; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Mann BF; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Milczek EM; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Mitchell V; Codexis Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA.
Nazor J; Codexis Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA.
Neri C; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Orr RK; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Orth P; Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ 07033, USA.
Phillips EM; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Riggins JN; Codexis Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA.
Schafer WA; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Silverman SM; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Strulson CA; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Subramanian N; Codexis Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA.
Voladri R; Codexis Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA.
Yang H; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Yang J; Codexis Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA.
Yi X; Codexis Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA.
Zhang X; Codexis Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA.
Zhong W; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2022 Jun 17; Vol. 376 (6599), pp. 1321-1327. Date of Electronic Publication: 2022 Jun 16.
Typ publikacji:: Journal Article
MeSH Terms:: Insulin*/analogs & derivatives
Insulin*/biosynthesis
Penicillin Amidase*/chemistry
Penicillin Amidase*/genetics
Peptides*/chemistry
Peptides*/genetics
Protein Engineering*/methods
Amino Acid Sequence ; Humans ; Lysine/chemistry

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Skocz do pozycji: 3.

Tytuł:: Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease.
Autorzy:: Pechenov S; Drug Delivery, Dosage Form Design and Development, AstraZeneca, Gaithersburg, MD, USA.
Revell J; Discovery Sciences, AstraZeneca R&D, Cambridge, UK.
Will S; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
Naylor J; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Tyagi P; Drug Delivery, Dosage Form Design and Development, AstraZeneca, Gaithersburg, MD, USA.
Patel C; Drug Delivery, Dosage Form Design and Development, AstraZeneca, Gaithersburg, MD, USA.
Liang L; Bioscience Renal, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Tseng L; Bioscience Renal, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, South San Francisco, CA, USA.
Huang Y; Bioscience Renal, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, South San Francisco, CA, USA.
Rosenbaum AI; Integrated Bioanalysis, Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, South San Francisco, CA, USA.
Balic K; Integrated Bioanalysis, Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, South San Francisco, CA, USA.
Konkar A; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
Grimsby J; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
Subramony JA; Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Nov 18; Vol. 11 (1), pp. 22521. Date of Electronic Publication: 2021 Nov 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Chronic Disease*/drug therapy
Drug Delivery Systems*
Glucagon-Like Peptide-1 Receptor*/agonists
Peptides*/chemistry
Protein Engineering*/methods
Animals ; Cricetinae ; Humans ; Male ; Mice ; Administration, Oral ; Caco-2 Cells ; Chemistry, Pharmaceutical/methods ; Chenodeoxycholic Acid/administration & dosage ; CHO Cells ; Cricetulus ; Diabetes Mellitus, Type 2/drug therapy ; Drug Discovery ; Insulin-Secreting Cells/cytology ; Mice, Inbred C57BL ; Propyl Gallate/administration & dosage ; Receptors, Glucagon/agonists ; Tablets, Enteric-Coated

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Skocz do pozycji: 4.

Tytuł:: Potential of peptide-engineered exosomes with overexpressed miR-92b-3p in anti-angiogenic therapy of ovarian cancer.
Autorzy:: Wang J; Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Wang C; Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Li Y; Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Li M; Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Zhu T; Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Shen Z; Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Wang H; Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Lv W; Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Wang X; Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Cheng X; Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Xie X; Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.; Pokaż więcej
Źródło:: Clinical and translational medicine [Clin Transl Med] 2021 May; Vol. 11 (5), pp. e425.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Protein Engineering*
Angiogenesis Inhibitors/*therapeutic use
Exosomes/*metabolism
MicroRNAs/*genetics
Neovascularization, Pathologic/*drug therapy
Ovarian Neoplasms/*drug therapy
Peptides/*metabolism
Animals ; Cell Line, Tumor ; Female ; Human Umbilical Vein Endothelial Cells ; Humans ; Mice ; Mice, Nude ; Ovarian Neoplasms/blood supply ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Pyridines/therapeutic use ; SOXC Transcription Factors/metabolism ; Xenograft Model Antitumor Assays ; Zebrafish

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Skocz do pozycji: 5.

Tytuł:: Structure-function engineering of novel fish gelatin-derived multifunctional peptides using high-resolution peptidomics and bioinformatics.
Autorzy:: Mirzapour-Kouhdasht A; Department of Food Science and Technology, School of Agriculture, Shiraz University, Shiraz, Iran. .; Seafood Processing Research Group, School of Agriculture, Shiraz University, Shiraz, Iran. .; Department of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju, South Korea. .
Moosavi-Nasab M; Department of Food Science and Technology, School of Agriculture, Shiraz University, Shiraz, Iran. .; Seafood Processing Research Group, School of Agriculture, Shiraz University, Shiraz, Iran. .
Lee CW; Department of Chemistry, Chonnam National University, Gwangju, 61186, South Korea.
Yun H; Department of Chemistry, Chonnam National University, Gwangju, 61186, South Korea.
Eun JB; Department of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju, South Korea. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Apr 01; Vol. 11 (1), pp. 7401. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Computational Biology*/methods
Protein Engineering*/methods
Proteomics*/methods
Fish Proteins/*chemistry
Gelatin/*chemistry
Peptides/*chemistry
Angiotensin-Converting Enzyme Inhibitors/chemistry ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Binding Sites ; Chromatography/methods ; Gelatin/isolation & purification ; Hydrolysis ; Peptides/pharmacology ; Peptidyl-Dipeptidase A/chemistry ; Protein Binding ; Protein Conformation ; Spectrum Analysis ; Structure-Activity Relationship ; Ultrafiltration/methods

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Skocz do pozycji: 6.

Tytuł:: Engineered Bio-inspired Multifunctional Peptide- and Protein-based Therapeutic Biomolecules for Better Wound Care.
Autorzy:: Gayen P; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, 741246, Mohanpur, India.
Jan S; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, 741246, Mohanpur, India.
Chowdhury N; Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, 741235, Nadia, West Bengal, India.
Ghosh S; Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, 741246, Mohanpur, India.
Hembram M; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, 741246, Mohanpur, India.
Bagchi A; Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, 741235, Nadia, West Bengal, India.
Sinha Roy R; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, 741246, Mohanpur, India.; Centre for Advanced Functional Materials, Indian Institute of Science Education and Research Kolkata, 741246, Mohanpur, India.; Centre for Climate and Environmental Studies, Indian Institute of Science Education and Research Kolkata, 741246, Mohanpur, India.; Pokaż więcej
Źródło:: Chemistry, an Asian journal [Chem Asian J] 2021 Dec 13; Vol. 16 (24), pp. 4018-4036. Date of Electronic Publication: 2021 Nov 08.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Intercellular Signaling Peptides and Proteins/*pharmacology
Peptides/*pharmacology
Proteins/*pharmacology
Wound Healing/*drug effects
Animals ; Blood Coagulation/drug effects ; Blood Coagulation/physiology ; Drug Delivery Systems ; Hemostatics/pharmacology ; Humans ; Intercellular Signaling Peptides and Proteins/genetics ; Neovascularization, Physiologic/drug effects ; Peptides/genetics ; Protein Engineering ; Proteins/genetics ; Wound Healing/physiology

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Skocz do pozycji: 7.

Tytuł:: A high-throughput pipeline for design and selection of peptides targeting the SARS-Cov-2 Spike protein.
Autorzy:: Wolfe M; 711th Human Performance Wing, Air Force Research Laboratory, Wright-Patterson Air Force Base, Dayton, OH, 45433, USA.; UES, Inc., Dayton, OH, 45432, USA.
Webb S; 711th Human Performance Wing, Air Force Research Laboratory, Wright-Patterson Air Force Base, Dayton, OH, 45433, USA.; UES, Inc., Dayton, OH, 45432, USA.
Chushak Y; 711th Human Performance Wing, Air Force Research Laboratory, Wright-Patterson Air Force Base, Dayton, OH, 45433, USA.; Henry M. Jackson Foundation, Dayton, OH, 45433, USA.
Krabacher R; 711th Human Performance Wing, Air Force Research Laboratory, Wright-Patterson Air Force Base, Dayton, OH, 45433, USA.; Materials & Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson Air Force Base, Dayton, OH, 45433, USA.
Liu Y; Department of Electrical and Computer Engineering, University of Virginia, Charlottesville, VA, 22904, USA.
Swami N; Department of Electrical and Computer Engineering, University of Virginia, Charlottesville, VA, 22904, USA.
Harbaugh S; 711th Human Performance Wing, Air Force Research Laboratory, Wright-Patterson Air Force Base, Dayton, OH, 45433, USA.
Chávez J; 711th Human Performance Wing, Air Force Research Laboratory, Wright-Patterson Air Force Base, Dayton, OH, 45433, USA. jorge.chavez_.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Nov 05; Vol. 11 (1), pp. 21768. Date of Electronic Publication: 2021 Nov 05.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Combinatorial Chemistry Techniques*
SARS-CoV-2*
COVID-19/*immunology
Peptides/*chemistry
Spike Glycoprotein, Coronavirus/*chemistry
COVID-19/virology ; Computational Biology ; Electrochemistry/methods ; Enzyme-Linked Immunosorbent Assay ; Humans ; Interferometry ; Kinetics ; Peptide Library ; Protein Array Analysis ; Protein Engineering ; Saliva/immunology

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Skocz do pozycji: 8.

Tytuł:: Protein-engineered molecules carrying GAD65 epitopes and targeting CD35 selectively down-modulate disease-associated human B lymphocytes.
Autorzy:: Manoylov IK; Laboratory of Experimental Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Boneva GV; Laboratory of Experimental Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Doytchinova IA; Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria.
Mihaylova NM; Laboratory of Experimental Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Tchorbanov AI; Laboratory of Experimental Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.; National Institute of Immunology, Sofia, Bulgaria.; Pokaż więcej
Źródło:: Clinical and experimental immunology [Clin Exp Immunol] 2019 Sep; Vol. 197 (3), pp. 329-340. Date of Electronic Publication: 2019 May 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antibodies, Monoclonal*/chemistry
Antibodies, Monoclonal*/genetics
Antibodies, Monoclonal*/pharmacology
Epitopes, B-Lymphocyte*/chemistry
Epitopes, B-Lymphocyte*/genetics
Epitopes, B-Lymphocyte*/pharmacology
Glutamate Decarboxylase*/chemistry
Glutamate Decarboxylase*/genetics
Glutamate Decarboxylase*/pharmacology
Peptides*/chemistry
Peptides*/genetics
Peptides*/pharmacology
Protein Engineering*
Receptors, Complement 3b*/antagonists & inhibitors
Receptors, Complement 3b*/genetics
Receptors, Complement 3b*/immunology
Adult ; Autoantibodies/genetics ; Autoantibodies/immunology ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/immunology ; Diabetes Mellitus, Type 1/pathology ; Female ; Humans ; Male ; Receptors, Antigen, B-Cell/genetics ; Receptors, Antigen, B-Cell/immunology ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/pharmacology

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Skocz do pozycji: 9.

Tytuł:: An efficient expression tag library based on self-assembling amphipathic peptides.
Autorzy:: Zhao W; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi, 214122, China.; School of Biotechnology, Jiangnan University, Wuxi, 214122, China.
Liu S; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi, 214122, China. .; School of Biotechnology, Jiangnan University, Wuxi, 214122, China. .
Du G; School of Biotechnology, Jiangnan University, Wuxi, 214122, China.; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
Zhou J; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi, 214122, China.; School of Biotechnology, Jiangnan University, Wuxi, 214122, China.; Jiangsu Provisional Research Center for Bioactive Product Processing Technology, Jiangnan University, Wuxi, 214122, China.; Pokaż więcej
Źródło:: Microbial cell factories [Microb Cell Fact] 2019 May 27; Vol. 18 (1), pp. 91. Date of Electronic Publication: 2019 May 27.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Library*
Protein Engineering*
Escherichia coli/*genetics
Peptides/*genetics
Recombinant Fusion Proteins/*genetics
Green Fluorescent Proteins/chemistry ; High-Throughput Screening Assays ; Hydrophobic and Hydrophilic Interactions ; Inclusion Bodies/metabolism

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Skocz do pozycji: 10.

Tytuł:: A Collection of Designed Peptides to Target SARS-CoV-2 Spike RBD-ACE2 Interaction.
Autorzy:: Fernandez-Fuentes N; Institute of Biological, Environmental and Rural Science, Aberystwyth University, Aberystwyth SY233EB, UK.
Molina R; Structural Bioinformatics Lab, Department of Experimental and Health Sciences, University Pompeu Fabra, 08003 Barcelona, Spain.
Oliva B; Structural Bioinformatics Lab, Department of Experimental and Health Sciences, University Pompeu Fabra, 08003 Barcelona, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Oct 27; Vol. 22 (21). Date of Electronic Publication: 2021 Oct 27.
Typ publikacji:: Journal Article
MeSH Terms:: Angiotensin-Converting Enzyme 2/*chemistry
Angiotensin-Converting Enzyme 2/*metabolism
Host-Pathogen Interactions/*drug effects
Peptides/*pharmacology
Spike Glycoprotein, Coronavirus/*metabolism
Binding Sites ; Databases, Factual ; Humans ; Models, Molecular ; Peptide Library ; Peptides/chemistry ; Protein Conformation ; Protein Domains ; Protein Engineering ; SARS-CoV-2/pathogenicity ; Spike Glycoprotein, Coronavirus/chemistry

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Skocz do pozycji: 11.

Tytuł:: Antisense Peptide Technology for Diagnostic Tests and Bioengineering Research.
Autorzy:: Štambuk N; Center for Nuclear Magnetic Resonance, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia.
Konjevoda P; Laboratory for Epigenomics, Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia.
Pavan J; Department of Ophthalmology, University Hospital Dubrava, Avenija Gojka Šuška 6, HR-10000 Zagreb, Croatia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Aug 24; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 24.
Typ publikacji:: Journal Article; Review
MeSH Terms:: COVID-19/*diagnosis
COVID-19 Serological Testing/*methods
Peptides/*metabolism
Protein Engineering/*methods
Spike Glycoprotein, Coronavirus/*isolation & purification
Algorithms ; Amino Acid Sequence/genetics ; Binding Sites/genetics ; COVID-19/blood ; COVID-19/virology ; Humans ; Immunochemistry/methods ; Molecular Docking Simulation ; Peptides/genetics ; Protein Binding/genetics ; SARS-CoV-2/isolation & purification ; Spike Glycoprotein, Coronavirus/metabolism

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Skocz do pozycji: 12.

Tytuł:: Coiled-coil heterodimers with increased stability for cellular regulation and sensing SARS-CoV-2 spike protein-mediated cell fusion.
Autorzy:: Plaper T; Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1001, Ljubljana, Slovenia.; Interfaculty Doctoral Study of Biomedicine, University of Ljubljana, Ljubljana, Slovenia.
Aupič J; Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1001, Ljubljana, Slovenia.
Dekleva P; Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1001, Ljubljana, Slovenia.
Lapenta F; Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1001, Ljubljana, Slovenia.; EN-FIST Centre of Excellence, Trg Osvobodilne Fronte 13, 1000, Ljubljana, Slovenia.
Keber MM; Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1001, Ljubljana, Slovenia.; EN-FIST Centre of Excellence, Trg Osvobodilne Fronte 13, 1000, Ljubljana, Slovenia.
Jerala R; Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1001, Ljubljana, Slovenia. .; EN-FIST Centre of Excellence, Trg Osvobodilne Fronte 13, 1000, Ljubljana, Slovenia. .
Benčina M; Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1001, Ljubljana, Slovenia. .; EN-FIST Centre of Excellence, Trg Osvobodilne Fronte 13, 1000, Ljubljana, Slovenia. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Apr 28; Vol. 11 (1), pp. 9136. Date of Electronic Publication: 2021 Apr 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Host-Pathogen Interactions/*physiology
Peptides/*chemistry
Peptides/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Cell Fusion ; Circular Dichroism ; Giant Cells/virology ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; HEK293 Cells ; Humans ; Luciferases/genetics ; Luciferases/metabolism ; Membrane Fusion ; Peptides/genetics ; Protein Engineering/methods ; Protein Multimerization ; Protein Stability ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Transcription, Genetic

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Skocz do pozycji: 13.

Tytuł:: Engineering Peptide-Based Polyelectrolyte Complexes with Increased Hydrophobicity.
Autorzy:: Tabandeh S; Department of Materials Science and Engineering, University of Central Florida, Orlando, FL 32816, USA. .
Leon L; Department of Materials Science and Engineering, University of Central Florida, Orlando, FL 32816, USA. .; NanoScience Technology Center, University of Central Florida, Orlando, FL 32826, USA. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2019 Mar 01; Vol. 24 (5). Date of Electronic Publication: 2019 Mar 01.
Typ publikacji:: Journal Article
MeSH Terms:: Drug Delivery Systems*
Protein Engineering*
Peptides/*chemistry
Polyelectrolytes/*chemistry
Circular Dichroism ; Glutamic Acid/chemistry ; Humans ; Hydrophobic and Hydrophilic Interactions ; Lysine/chemistry ; Mass Spectrometry ; Peptides/chemical synthesis ; Peptides/pharmacology ; Polyamines/chemical synthesis ; Polyamines/chemistry ; Polyelectrolytes/chemical synthesis ; Polyelectrolytes/pharmacology ; Polymers/chemical synthesis ; Polymers/chemistry ; Static Electricity

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Skocz do pozycji: 14.

Tytuł:: EGFR-Binding Peptides: From Computational Design towards Tumor-Targeting of Adeno-Associated Virus Capsids.
Autorzy:: Feiner RC; Cellular and Molecular Biotechnology, Faculty of Technology, Bielefeld University, 33615 Bielefeld, Germany.
Kemker I; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, 33615 Bielefeld, Germany.
Krutzke L; Department of Gene Therapy, Ulm University, 89081 Ulm, Germany.
Allmendinger E; Department of Gene Therapy, Ulm University, 89081 Ulm, Germany.
Mandell DJ; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA.; Bioinformatics Graduate Program, University of California San Francisco, San Francisco, CA 94134, USA.
Sewald N; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, 33615 Bielefeld, Germany.
Kochanek S; Department of Gene Therapy, Ulm University, 89081 Ulm, Germany.
Müller KM; Cellular and Molecular Biotechnology, Faculty of Technology, Bielefeld University, 33615 Bielefeld, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Dec 15; Vol. 21 (24). Date of Electronic Publication: 2020 Dec 15.
Typ publikacji:: Journal Article
MeSH Terms:: Dependovirus/*metabolism
Oncolytic Viruses/*chemistry
Peptides/*chemistry
Protein Engineering/*methods
Animals ; Capsid/chemistry ; Capsid/metabolism ; Capsid Proteins/chemistry ; Capsid Proteins/metabolism ; Cell Line, Tumor ; Chick Embryo ; Chorioallantoic Membrane/metabolism ; Circular Dichroism ; Computational Biology ; Dependovirus/chemistry ; Dimerization ; ErbB Receptors/chemistry ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Genetic Therapy ; Genetic Vectors ; Humans ; Microscopy, Fluorescence ; Oncolytic Viruses/genetics ; Oncolytic Viruses/metabolism ; Peptides/chemical synthesis ; Protein Binding ; Transplantation, Heterologous ; Up-Regulation ; Wound Healing/drug effects

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Skocz do pozycji: 15.

Tytuł:: A novel synthetic trivalent single chain variable fragment (tri-scFv) construction platform based on the SpyTag/SpyCatcher protein ligase system.
Autorzy:: Alam MK; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Room 2841, Royal University Hospital, 103 Hospital Drive, Saskatoon, S7N 0W8, Canada.
Brabant M; Department of Biochemistry, College of Medicine, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada.
Viswas RS; Medical Imaging, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada.
Barreto K; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Room 2841, Royal University Hospital, 103 Hospital Drive, Saskatoon, S7N 0W8, Canada.
Fonge H; Medical Imaging, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada.
Ronald Geyer C; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Room 2841, Royal University Hospital, 103 Hospital Drive, Saskatoon, S7N 0W8, Canada. .; Pokaż więcej
Źródło:: BMC biotechnology [BMC Biotechnol] 2018 Sep 10; Vol. 18 (1), pp. 55. Date of Electronic Publication: 2018 Sep 10.
Typ publikacji:: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Ligases/*chemistry
Peptides/*genetics
Protein Engineering/*methods
Receptor, ErbB-3/*immunology
Single-Chain Antibodies/*genetics
Antibody Affinity ; Humans ; Peptides/immunology ; Protein Engineering/instrumentation ; Receptor, ErbB-3/genetics ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/immunology ; Single-Chain Antibodies/immunology

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Skocz do pozycji: 16.

Tytuł:: Discovery of Klotho peptide antagonists against Wnt3 and Wnt3a target proteins using combination of protein engineering, protein-protein docking, peptide docking and molecular dynamics simulations.
Autorzy:: Mirza SB; a Department of Biophysics, School of Medicine , Bahcesehir University (BAU) , Istanbul , Turkey.; b Department of Biosciences , COMSATS Institute of Information Technology (CIIT) , Islamabad , Pakistan.
Ekhteiari Salmas R; a Department of Biophysics, School of Medicine , Bahcesehir University (BAU) , Istanbul , Turkey.
Fatmi MQ; b Department of Biosciences , COMSATS Institute of Information Technology (CIIT) , Islamabad , Pakistan.
Durdagi S; a Department of Biophysics, School of Medicine , Bahcesehir University (BAU) , Istanbul , Turkey.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2017 Dec; Vol. 32 (1), pp. 84-98. Date of Electronic Publication: 2016 Oct 21.
Typ publikacji:: Journal Article
MeSH Terms:: Protein Engineering*
Glucuronidase/*chemistry
Peptides/*pharmacology
Wnt3 Protein/*antagonists & inhibitors
Amino Acid Sequence ; Animals ; Humans ; Klotho Proteins ; Mice ; Molecular Dynamics Simulation ; Peptides/chemistry

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Skocz do pozycji: 17.

Tytuł:: Sequence Engineering to Control the Helix Handedness of Peptide Foldamers.
Autorzy:: Rudzińska-Szostak E; Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wyb. Wyspiańskiego 27, 50-370, Wrocław, Poland.
Berlicki Ł; Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wyb. Wyspiańskiego 27, 50-370, Wrocław, Poland.; Pokaż więcej
Źródło:: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2017 Oct 26; Vol. 23 (60), pp. 14980-14986. Date of Electronic Publication: 2017 Oct 04.
Typ publikacji:: Journal Article
MeSH Terms:: Protein Engineering*
Peptides/*chemistry
Amino Acid Sequence ; Amino Acids/chemistry ; Gramicidin/chemistry ; Gramicidin/metabolism ; Peptides/metabolism ; Protein Structure, Secondary ; Stereoisomerism

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Skocz do pozycji: 18.

Tytuł:: A simpler and more cost-effective peptide biosynthetic method using the truncated GST as carrier for epitope mapping.
Autorzy:: Xu WX; Division of Reproductive Immunology, Key Lab of Reproduction Regulation of NPFPC, Shanghai Institute of Planned Parenthood Research, Fudan University, Shanghai, P. R. China.
Wang J; Division of Reproductive Immunology, Key Lab of Reproduction Regulation of NPFPC, Shanghai Institute of Planned Parenthood Research, Fudan University, Shanghai, P. R. China.
Tang HP; Division of Reproductive Immunology, Key Lab of Reproduction Regulation of NPFPC, Shanghai Institute of Planned Parenthood Research, Fudan University, Shanghai, P. R. China.
Chen LH; Division of Reproductive Immunology, Key Lab of Reproduction Regulation of NPFPC, Shanghai Institute of Planned Parenthood Research, Fudan University, Shanghai, P. R. China.
Lian WB; Division of Reproductive Immunology, Key Lab of Reproduction Regulation of NPFPC, Shanghai Institute of Planned Parenthood Research, Fudan University, Shanghai, P. R. China.
Zhan JM; Division of Reproductive Immunology, Key Lab of Reproduction Regulation of NPFPC, Shanghai Institute of Planned Parenthood Research, Fudan University, Shanghai, P. R. China.
Gupta SK; Reproductive Cell Biology Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India.
Ji CN; State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, P. R. China.
Gu SH; State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, P. R. China.
Xie Y; State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, P. R. China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2017 Oct 12; Vol. 12 (10), pp. e0186097. Date of Electronic Publication: 2017 Oct 12 (Print Publication: 2017).
Typ publikacji:: Journal Article
MeSH Terms:: Epitope Mapping/*methods
Glutathione Transferase/*metabolism
Peptides/*metabolism
Plasmids/*genetics
Protein Engineering/*methods
Animals ; Antibodies, Monoclonal/metabolism ; Epitope Mapping/economics ; Glutathione Transferase/genetics ; Immunization ; Male ; Oncogene Proteins, Viral/genetics ; Peptides/immunology ; Protein Engineering/economics ; Rabbits ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism

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Skocz do pozycji: 19.

Tytuł:: Improved activity and expression of recombinant human factor IX by propeptide engineering.
Autorzy:: Vatandoost J; Department of Biology, Hakim Sabzevari University, Sabzevar, Iran. .
Bos MHA; Division of Thrombosis and Hemostasis, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Pokaż więcej
Źródło:: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences [Daru] 2019 Dec; Vol. 27 (2), pp. 653-660. Date of Electronic Publication: 2019 Oct 21.
Typ publikacji:: Journal Article
MeSH Terms:: Factor IX/*chemistry
Factor IX/*genetics
Peptides/*metabolism
Prothrombin/*genetics
Amino Acid Substitution ; Binding Sites ; Factor IX/metabolism ; Gene Expression ; Humans ; Hydrophobic and Hydrophilic Interactions ; Peptides/chemistry ; Peptides/genetics ; Protein Engineering ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism

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Skocz do pozycji: 20.

Tytuł:: (F)uridylylated Peptides Linked to VPg1 of Foot-and- Mouth Disease Virus (FMDV): Design, Synthesis and X-Ray Crystallography of the Complexes with FMDV RNA-Dependent RNA Polymerase.
Autorzy:: de Castro S; Instituto de Química Médica (IQM-CSIC), Juan de la Cierva 3, E-28006 Madrid, Spain. .
Ferrer-Orta C; Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Parc Científic de Barcelona, Josep Samitier 1-5, 08028 Barcelona, Spain.
Mills A; Area de Farmacología, Departamento de Ciencias Biomédicas, Unidad Asociada al IQM-CSIC, Universidad de Alcalá, E-28805 Alcalá de Henares, Madrid, Spain.
Fernández-Cureses G; Instituto de Química Médica (IQM-CSIC), Juan de la Cierva 3, E-28006 Madrid, Spain.
Gago F; Area de Farmacología, Departamento de Ciencias Biomédicas, Unidad Asociada al IQM-CSIC, Universidad de Alcalá, E-28805 Alcalá de Henares, Madrid, Spain.
Verdaguer N; Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Parc Científic de Barcelona, Josep Samitier 1-5, 08028 Barcelona, Spain.
Camarasa MJ; Instituto de Química Médica (IQM-CSIC), Juan de la Cierva 3, E-28006 Madrid, Spain. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2019 Jun 26; Vol. 24 (13). Date of Electronic Publication: 2019 Jun 26.
Typ publikacji:: Journal Article
MeSH Terms:: Foot-and-Mouth Disease Virus/*metabolism
Peptides/*chemistry
Viral Proteins/*chemistry
Amino Acid Sequence ; Models, Molecular ; Molecular Conformation ; Protein Engineering ; RNA-Dependent RNA Polymerase/chemical synthesis ; RNA-Dependent RNA Polymerase/chemistry ; RNA-Dependent RNA Polymerase/metabolism ; Structure-Activity Relationship ; Uridine Monophosphate/chemistry ; Viral Proteins/chemical synthesis ; Viral Proteins/metabolism

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