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Tytuł:
High-Affinity Fluorogenic Substrate for Tissue Transglutaminase Reveals Enzymatic Hysteresis.
Autorzy:
Gates EWJ; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.
Prince-Hallée A; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.
Heidari Y; Dalriada Drug Discovery, Mississauga, Ontario L5N 8G4, Canada.
Sedighi A; Dalriada Drug Discovery, Mississauga, Ontario L5N 8G4, Canada.
Keillor JW; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.
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Źródło:
Biochemistry [Biochemistry] 2023 Nov 07; Vol. 62 (21), pp. 3085-3095. Date of Electronic Publication: 2023 Oct 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Glutamine gamma Glutamyltransferase 2*
Fluorescent Dyes*
Humans ; Isoenzymes/metabolism ; Transglutaminases ; Binding Sites
Czasopismo naukowe
Szczegóły
Tytuł:
Metabolic characterisation of transglutaminase 2 inhibitor effects in breast cancer cell lines.
Autorzy:
Gallo M; Department of Medicine and Surgery, University of Parma, Italy.
Ferrari E; Department of Medicine and Surgery, University of Parma, Italy.
Terrazzan A; Department of Translational Medicine, University of Ferrara, Italy.
Brugnoli F; Department of Translational Medicine, University of Ferrara, Italy.
Spisni A; Department of Medicine and Surgery, University of Parma, Italy.
Taccioli C; Department of Animal Medicine, Production and Health (MAPS), University of Padua, Italy.
Aguiari G; Department of Neuroscience and Rehabilitation, University of Ferrara, Italy.
Trentini A; Department of Environmental Sciences and Prevention, University of Ferrara, Italy.
Volinia S; Department of Translational Medicine, University of Ferrara, Italy.
Keillor JW; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Canada.
Bergamini CM; Department of Neuroscience and Rehabilitation, University of Ferrara, Italy.
Bianchi N; Department of Translational Medicine, University of Ferrara, Italy.
Pertinhez TA; Department of Medicine and Surgery, University of Parma, Italy.
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Źródło:
The FEBS journal [FEBS J] 2023 Nov; Vol. 290 (22), pp. 5411-5433. Date of Electronic Publication: 2023 Aug 29.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Glutamine gamma Glutamyltransferase 2*
Breast Neoplasms*/metabolism
Humans ; Female ; MCF-7 Cells ; Apoptosis ; Metabolomics ; Cell Line, Tumor ; Transglutaminases/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Microglial transglutaminase 2 deficiency causes impaired synaptic remodelling and cognitive deficits in mice.
Autorzy:
Liu C; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
Gao X; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Shi RX; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Wang YY; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
He XC; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
Du HZ; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
Hu B; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Jiao J; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Liu CM; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Teng ZQ; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
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Źródło:
Cell proliferation [Cell Prolif] 2023 Sep; Vol. 56 (9), pp. e13439. Date of Electronic Publication: 2023 Mar 06.
Typ publikacji:
Journal Article
MeSH Terms:
Microglia*/metabolism
Protein Glutamine gamma Glutamyltransferase 2*
Mice ; Animals ; Neurons/metabolism ; Brain ; Cognition
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cell-Impermeable Inhibitors Confirm That Intracellular Human Transglutaminase 2 Is Responsible for the Transglutaminase-Associated Cancer Phenotype.
Autorzy:
Gates EWJ; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Calvert ND; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Cundy NJ; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Brugnoli F; Department of Translational Medicine, University of Ferrara, 44021 Ferrara, Italy.
Navals P; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Kirby A; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Bianchi N; Department of Translational Medicine, University of Ferrara, 44021 Ferrara, Italy.
Adhikary G; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Shuhendler AJ; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Eckert RL; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Keillor JW; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 08; Vol. 24 (16). Date of Electronic Publication: 2023 Aug 08.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Glutamine gamma Glutamyltransferase 2*
Neoplasms*
Humans ; Transglutaminases ; Fluorescent Dyes ; Phenotype
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Biochemical and Functional Characterization of the Three Zebrafish Transglutaminases 2.
Autorzy:
Lisetto M; Department of Life Sciences, University of Trieste, 34127 Trieste, Italy.
Fattorini M; Department of Life Sciences, University of Trieste, 34127 Trieste, Italy.
Lanza A; Department of Life Sciences, University of Trieste, 34127 Trieste, Italy.
Gerdol M; Department of Life Sciences, University of Trieste, 34127 Trieste, Italy.
Griffin M; College of Health and Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Wang Z; College of Health and Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Ferrara F; Specifica a Q2 Solutions Company, Santa Fe, NM 87501, USA.
Sblattero D; Department of Life Sciences, University of Trieste, 34127 Trieste, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 27; Vol. 24 (15). Date of Electronic Publication: 2023 Jul 27.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Glutamine gamma Glutamyltransferase 2*
Zebrafish*/genetics
Zebrafish*/metabolism
Animals ; Humans ; Transglutaminases/genetics ; Transglutaminases/metabolism ; HEK293 Cells ; GTP-Binding Proteins/genetics ; GTP-Binding Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Discovery and Characterization of PROTACs Targeting Tissue Transglutaminase (TG2).
Autorzy:
Valdivia A; Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States.
Vagadia PP; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
Guo G; WuXi AppTec, Shanghai 200131, People's Republic of China.
O'Brien E; Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States.
Matei D; Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States.; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States.; Jesse Brown VA Medical Center, Chicago, Illinois 60612, United States.
Schiltz GE; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States.; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2023 Jul 27; Vol. 66 (14), pp. 9445-9465. Date of Electronic Publication: 2023 Jul 14.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Protein Glutamine gamma Glutamyltransferase 2*
Transglutaminases*
Female ; Humans ; Proteolysis Targeting Chimera ; GTP-Binding Proteins/metabolism ; Cell Adhesion
Czasopismo naukowe
Szczegóły
Tytuł:
Transglutaminase 2 Facilitates Murine Wound Healing in a Strain-Dependent Manner.
Autorzy:
Yiu TW; Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia.
Holman SR; Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia.
Kaidonis X; Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia.
Graham RM; Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia.; School of Clinical Medicine, UNSW Medicine and Health, University of New South Wales Sydney, Kensington, NSW 2052, Australia.
Iismaa SE; Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia.; School of Clinical Medicine, UNSW Medicine and Health, University of New South Wales Sydney, Kensington, NSW 2052, Australia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 14; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 14.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Glutamine gamma Glutamyltransferase 2*
GTP-Binding Proteins*/metabolism
Mice ; Animals ; Mice, Inbred C57BL ; Wound Healing/genetics ; Mice, Knockout ; Syndecans/metabolism ; Integrins/metabolism ; RNA, Messenger ; Transglutaminases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
S-Nitrosylation of Tissue Transglutaminase in Modulating Glycolysis, Oxidative Stress, and Inflammatory Responses in Normal and Indoxyl-Sulfate-Induced Endothelial Cells.
Autorzy:
Lin CJ; Department of Medicine, MacKay Medical College, New Taipei 25245, Taiwan.; MacKay Junior College of Medicine, Nursing and Management, New Taipei 25245, Taiwan.; Division of Nephrology, Department of Internal Medicine, MacKay Memorial Hospital, New Taipei 25245, Taiwan.
Chiu CY; Institute of Biomedical Sciences, MacKay Medical College, New Taipei 25245, Taiwan.
Liao EC; Department of Medicine, MacKay Medical College, New Taipei 25245, Taiwan.
Wu CJ; Department of Medicine, MacKay Medical College, New Taipei 25245, Taiwan.; MacKay Junior College of Medicine, Nursing and Management, New Taipei 25245, Taiwan.; Division of Nephrology, Department of Internal Medicine, MacKay Memorial Hospital, New Taipei 25245, Taiwan.
Chung CH; Department of Medicine, MacKay Medical College, New Taipei 25245, Taiwan.
Greenberg CS; Division of Hematology/Oncology, Medical University of South Carolina, Charleston, SC 29425, USA.
Lai TS; Institute of Biomedical Sciences, MacKay Medical College, New Taipei 25245, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 30; Vol. 24 (13). Date of Electronic Publication: 2023 Jun 30.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Glutamine gamma Glutamyltransferase 2*
Indican*
Humans ; Endothelial Cells ; Oxidative Stress ; Glycolysis ; Sulfates
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Expression of transglutaminase 2 in human gut epithelial cells: Implications for coeliac disease.
Autorzy:
Amundsen SF; KG Jebsen Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital-Rikshospitalet, Oslo, Norway.
Stamnaes J; KG Jebsen Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital-Rikshospitalet, Oslo, Norway.
Lundin KEA; KG Jebsen Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Oslo University Hospital-Rikshospitalet, Oslo, Norway.
Sollid LM; KG Jebsen Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital-Rikshospitalet, Oslo, Norway.
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Źródło:
PloS one [PLoS One] 2023 Jun 27; Vol. 18 (6), pp. e0287662. Date of Electronic Publication: 2023 Jun 27 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Celiac Disease*
Protein Glutamine gamma Glutamyltransferase 2*
Humans ; Autoantibodies ; Epithelial Cells/metabolism ; Glutens/metabolism ; Transglutaminases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Allosteric Activation of Transglutaminase 2 via Inducing an "Open" Conformation for Osteoblast Differentiation.
Autorzy:
Yang Z; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Zhang XW; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Zhuo FF; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Liu TT; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Luo QW; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Zheng YZ; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Li L; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Yang H; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Zhang YC; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Wang YH; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Liu D; Proteomics Laboratory, Medical and Healthy Analytical Center, Peking University Health Science Center, Beijing, 100191, China.
Tu PF; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Zeng KW; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
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Źródło:
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2023 Jun; Vol. 10 (18), pp. e2206533. Date of Electronic Publication: 2023 Apr 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Glutamine gamma Glutamyltransferase 2*
Osteoporosis*/drug therapy
Osteoporosis*/metabolism
Mice ; Animals ; Female ; Allosteric Regulation ; Osteogenesis ; Osteoblasts/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Inhibition of transglutaminase 2 (TG2) ameliorates ventricular fibrosis in isoproterenol-induced heart failure in rats.
Autorzy:
Al-U'datt DGF; Department of Physiology and Biochemistry, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan. Electronic address: .
Tranchant CC; School of Food Science, Nutrition and Family Studies, Faculty of Health Sciences and Community Services, Université de Moncton, New Brunswick, Canada.
Alu'datt M; Department of Nutrition and Food Technology, Faculty of Agriculture, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.
Abusara S; Department of Physiology and Biochemistry, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.
Al-Dwairi A; Department of Physiology and Biochemistry, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.
AlQudah M; Department of Physiology and Biochemistry, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan; Physiology Department, Arabian Gulf University, Manama, Bahrain.
Al-Shboul O; Department of Physiology and Biochemistry, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.
Hiram R; Montreal Heart Institute and Department of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Altuntas Y; Montreal Heart Institute and Department of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Jaradat S; Princess Haya Biotechnology Center, Jordan University of Science and Technology, Irbid 22110, Jordan.
Alzoubi KH; Department of Pharmacy Practice and Pharmacotherapeutics, University of Sharjah, Sharjah, United Arab Emirates; Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
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Źródło:
Life sciences [Life Sci] 2023 May 15; Vol. 321, pp. 121564. Date of Electronic Publication: 2023 Mar 15.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Glutamine gamma Glutamyltransferase 2*
Heart Failure*/chemically induced
Heart Failure*/drug therapy
Rats ; Animals ; Cystamine/pharmacology ; Cystamine/therapeutic use ; Isoproterenol/toxicity ; Creatinine ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Fibrosis ; Transglutaminases/genetics ; Collagen/metabolism ; Urea
Czasopismo naukowe
Szczegóły
Tytuł:
The transglutaminase 2 cancer cell survival factor maintains mTOR activity to drive an aggressive cancer phenotype.
Autorzy:
Chen X; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Adhikary G; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Newland JJ; Department of Surgery - Division of Thoracic Oncology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Xu W; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Ma E; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Naselsky W; Department of Surgery - Division of Thoracic Oncology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Eckert RL; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
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Źródło:
Molecular carcinogenesis [Mol Carcinog] 2023 Jan; Vol. 62 (1), pp. 90-100. Date of Electronic Publication: 2022 Jul 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Carcinoma, Squamous Cell*/metabolism
Protein Glutamine gamma Glutamyltransferase 2*/genetics
Protein Glutamine gamma Glutamyltransferase 2*/metabolism
Humans ; Cell Line, Tumor ; Cell Movement ; Cell Survival/genetics ; Epithelial-Mesenchymal Transition/genetics ; GTP-Binding Proteins/genetics ; GTP-Binding Proteins/metabolism ; Phenotype ; Signal Transduction/genetics ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Immuno-Sensing at Ultra-Low Concentration of TG2 Protein by Organic Electrochemical Transistors.
Autorzy:
Preziosi V; Department of Chemical, Materials and Production Engineering, University Federico II, P.le Tecchio 80, I-80125 Naples, Italy.
Barra M; CNR-SPIN, c/o Department of Physics 'Ettore Pancini', P.le Tecchio, 80, I-80125 Naples, Italy.
Villella VR; Department of Chemical, Materials and Production Engineering, University Federico II, P.le Tecchio 80, I-80125 Naples, Italy.; CEINGE, Advanced Biotechnologies, Via Gaetano Salvatore 486, I-80145 Naples, Italy.
Esposito S; Department of Chemical, Materials and Production Engineering, University Federico II, P.le Tecchio 80, I-80125 Naples, Italy.; CEINGE, Advanced Biotechnologies, Via Gaetano Salvatore 486, I-80145 Naples, Italy.
D'Angelo P; IMEM-CNR, Parco Area delle Scienze 37/A, I-43124 Parma, Italy.
Marasso SL; IMEM-CNR, Parco Area delle Scienze 37/A, I-43124 Parma, Italy.; ChiLab, Department of Applied Science and Technology, Politecnico di Torino, I-10129 Torino, Italy.
Cocuzza M; IMEM-CNR, Parco Area delle Scienze 37/A, I-43124 Parma, Italy.; ChiLab, Department of Applied Science and Technology, Politecnico di Torino, I-10129 Torino, Italy.
Cassinese A; CNR-SPIN, c/o Department of Physics 'Ettore Pancini', P.le Tecchio, 80, I-80125 Naples, Italy.; Department of Physics 'Ettore Pancini', University Federico II, P.le Tecchio 80, I-80125 Naples, Italy.
Guido S; Department of Chemical, Materials and Production Engineering, University Federico II, P.le Tecchio 80, I-80125 Naples, Italy.; CEINGE, Advanced Biotechnologies, Via Gaetano Salvatore 486, I-80145 Naples, Italy.; National Interuniversity Consortium for Materials Science and Technology (INSTM), I-50121 Firenze, Italy.
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Źródło:
Biosensors [Biosensors (Basel)] 2023 Mar 31; Vol. 13 (4). Date of Electronic Publication: 2023 Mar 31.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Glutamine gamma Glutamyltransferase 2*
GTP-Binding Proteins*/metabolism
Transglutaminases/metabolism ; Liver ; Apoptosis
Czasopismo naukowe
Szczegóły
Tytuł:
Deletion of Transglutaminase 2 from Mouse Astrocytes Significantly Improves Their Ability to Promote Neurite Outgrowth on an Inhibitory Matrix.
Autorzy:
Emerson J; Department of Anesthesiology and Perioperative Medicine, University of Rochester, 601 Elmwood Ave., Box 604, Rochester, NY 14620, USA.
Delgado T; Department of Anesthesiology and Perioperative Medicine, University of Rochester, 601 Elmwood Ave., Box 604, Rochester, NY 14620, USA.
Girardi P; Department of Anesthesiology and Perioperative Medicine, University of Rochester, 601 Elmwood Ave., Box 604, Rochester, NY 14620, USA.
Johnson GVW; Department of Anesthesiology and Perioperative Medicine, University of Rochester, 601 Elmwood Ave., Box 604, Rochester, NY 14620, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 23; Vol. 24 (7). Date of Electronic Publication: 2023 Mar 23.
Typ publikacji:
Journal Article
MeSH Terms:
Astrocytes*/metabolism
Protein Glutamine gamma Glutamyltransferase 2*
Animals ; Mice ; Cell Line, Tumor ; Cells, Cultured ; DNA-Binding Proteins/metabolism ; Neurites ; Neuronal Outgrowth ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophages.
Autorzy:
Shinoda Y; Cellular Biochemistry Lab., Graduate School of Pharmaceutical Sciences, Nagoya University, Tokai National Higher Education and Research System, Furo-cho, Chikusa, Nagoya, 464-8601, Japan.
Tatsukawa H; Cellular Biochemistry Lab., Graduate School of Pharmaceutical Sciences, Nagoya University, Tokai National Higher Education and Research System, Furo-cho, Chikusa, Nagoya, 464-8601, Japan. .
Yonaga A; Cellular Biochemistry Lab., Graduate School of Pharmaceutical Sciences, Nagoya University, Tokai National Higher Education and Research System, Furo-cho, Chikusa, Nagoya, 464-8601, Japan.
Wakita R; Cellular Biochemistry Lab., Graduate School of Pharmaceutical Sciences, Nagoya University, Tokai National Higher Education and Research System, Furo-cho, Chikusa, Nagoya, 464-8601, Japan.
Takeuchi T; Cellular Biochemistry Lab., Graduate School of Pharmaceutical Sciences, Nagoya University, Tokai National Higher Education and Research System, Furo-cho, Chikusa, Nagoya, 464-8601, Japan.
Tsuji T; Cellular Biochemistry Lab., Graduate School of Pharmaceutical Sciences, Nagoya University, Tokai National Higher Education and Research System, Furo-cho, Chikusa, Nagoya, 464-8601, Japan.
Tanaka M; Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Tokai National Higher Education and Research System, Furo-cho, Chikusa, Nagoya, 464-8601, Japan.; Department of Immunometabolism, Nagoya University Graduate School of Medicine, Tokai National Higher Education and Research System, Furo-cho, Chikusa, Nagoya, 464-8601, Japan.; Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, Tokai National Higher Education and Research System, Furo-cho, Chikusa, Nagoya, 464-8601, Japan.
Suganami T; Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Tokai National Higher Education and Research System, Furo-cho, Chikusa, Nagoya, 464-8601, Japan.; Department of Immunometabolism, Nagoya University Graduate School of Medicine, Tokai National Higher Education and Research System, Furo-cho, Chikusa, Nagoya, 464-8601, Japan.; Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, Tokai National Higher Education and Research System, Furo-cho, Chikusa, Nagoya, 464-8601, Japan.
Hitomi K; Cellular Biochemistry Lab., Graduate School of Pharmaceutical Sciences, Nagoya University, Tokai National Higher Education and Research System, Furo-cho, Chikusa, Nagoya, 464-8601, Japan.
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Źródło:
Cell death & disease [Cell Death Dis] 2023 Mar 02; Vol. 14 (2), pp. 136. Date of Electronic Publication: 2023 Mar 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Glutamine gamma Glutamyltransferase 2*
Kidney Diseases*
Humans ; Animals ; Mice ; Macrophages ; Monocytes ; Kidney
Czasopismo naukowe
Szczegóły
Tytuł:
Inhibition of Transglutaminase 2 as a Therapeutic Strategy in Celiac Disease-In Vitro Studies in Intestinal Cells and Duodenal Biopsies.
Autorzy:
Stricker S; Department of Pediatrics, Justus-Liebig-University Giessen, 35392 Giessen, Germany.
de Laffolie J; Department of Pediatrics, Justus-Liebig-University Giessen, 35392 Giessen, Germany.
Zimmer KP; Department of Pediatrics, Justus-Liebig-University Giessen, 35392 Giessen, Germany.
Rudloff S; Department of Pediatrics, Justus-Liebig-University Giessen, 35392 Giessen, Germany.; Institute of Nutritional Science, Justus-Liebig-University Giessen, 35392 Giessen, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 01; Vol. 24 (5). Date of Electronic Publication: 2023 Mar 01.
Typ publikacji:
Journal Article
MeSH Terms:
Celiac Disease*/drug therapy
Celiac Disease*/enzymology
Protein Glutamine gamma Glutamyltransferase 2*/antagonists & inhibitors
Humans ; Biopsy ; Caco-2 Cells ; Gliadin/metabolism ; Intestinal Mucosa/metabolism ; Peptides/metabolism ; Transglutaminases/metabolism ; Intestines/enzymology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Role and Mechanism of Transglutaminase 2 in Regulating Hippocampal Neurogenesis after Traumatic Brain Injury.
Autorzy:
Shi RX; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100408, China.
Liu C; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
Xu YJ; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
Wang YY; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100408, China.
He BD; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100408, China.
He XC; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
Du HZ; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
Hu B; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100408, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
Jiao J; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100408, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
Liu CM; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100408, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
Teng ZQ; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100408, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
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Źródło:
Cells [Cells] 2023 Feb 09; Vol. 12 (4). Date of Electronic Publication: 2023 Feb 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain Injuries, Traumatic*/physiopathology
Neurogenesis*
Protein Glutamine gamma Glutamyltransferase 2*/metabolism
Animals ; Mice ; Hippocampus/cytology ; Hippocampus/metabolism ; Mice, Knockout ; Neural Stem Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Impact of N -Acryloyllysine Piperazides on the Conformational Dynamics of Transglutaminase 2. -Acryloyllysine Piperazides on the Conformational Dynamics of Transglutaminase 2.
Autorzy:
Heerwig A; Kurt-Schwabe-Institut für Mess- und Sensortechnik Meinsberg e.V., 04736 Waldheim, Germany.
Kick A; Kurt-Schwabe-Institut für Mess- und Sensortechnik Meinsberg e.V., 04736 Waldheim, Germany.
Sommerfeld P; Institutes I & II of Pharmacology, Center of Pharmacology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
Eimermacher S; Institutes I & II of Pharmacology, Center of Pharmacology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
Hartung F; Institutes I & II of Pharmacology, Center of Pharmacology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
Laube M; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328 Dresden, Germany.; School of Science, Faculty of Chemistry and Food Chemistry, Technische Universität Dresden, 01062 Dresden, Germany.
Fischer D; Institutes I & II of Pharmacology, Center of Pharmacology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
Pietzsch HJ; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328 Dresden, Germany.; School of Science, Faculty of Chemistry and Food Chemistry, Technische Universität Dresden, 01062 Dresden, Germany.
Pietzsch J; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328 Dresden, Germany.; School of Science, Faculty of Chemistry and Food Chemistry, Technische Universität Dresden, 01062 Dresden, Germany.
Löser R; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328 Dresden, Germany.; School of Science, Faculty of Chemistry and Food Chemistry, Technische Universität Dresden, 01062 Dresden, Germany.
Mertig M; Kurt-Schwabe-Institut für Mess- und Sensortechnik Meinsberg e.V., 04736 Waldheim, Germany.; School of Science, Faculty of Chemistry and Food Chemistry, Technische Universität Dresden, 01062 Dresden, Germany.
Pietsch M; Institutes I & II of Pharmacology, Center of Pharmacology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
Wodtke R; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328 Dresden, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 13; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 13.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Glutamine gamma Glutamyltransferase 2*/chemistry
Protein Conformation*
Molecular Conformation ; Transglutaminases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
F-labeling and initial in vivo evaluation of a Hitomi peptide for imaging tissue transglutaminase 2.
Autorzy:
Ackermann U; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia; Faculty of Medicine, The University of Melbourne, Melbourne, Australia; Olivia Newton-John Cancer Research Institute, Melbourne, Australia; School of Cancer Medicine, La Trobe University, Melbourne, Australia. Electronic address: .
Jäger L; Faculty of Medicine, Eberhard Karls Universität Tübingen, Germany.
Rigopoulos A; Olivia Newton-John Cancer Research Institute, Melbourne, Australia.
Burvenich IJG; Olivia Newton-John Cancer Research Institute, Melbourne, Australia; School of Cancer Medicine, La Trobe University, Melbourne, Australia.
O'Keefe GJ; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia; Faculty of Medicine, The University of Melbourne, Melbourne, Australia; Olivia Newton-John Cancer Research Institute, Melbourne, Australia.
Scott AM; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia; Faculty of Medicine, The University of Melbourne, Melbourne, Australia; Olivia Newton-John Cancer Research Institute, Melbourne, Australia; School of Cancer Medicine, La Trobe University, Melbourne, Australia.
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Źródło:
Nuclear medicine and biology [Nucl Med Biol] 2023 Jan-Feb; Vol. 116-117, pp. 108308. Date of Electronic Publication: 2022 Nov 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Glutamine gamma Glutamyltransferase 2*
Peptides*
Humans ; Mice ; Animals ; Positron-Emission Tomography/methods ; Fluorine Radioisotopes ; Cell Line, Tumor
Czasopismo naukowe
Szczegóły
Tytuł:
Cytosolic TGM2 promotes malignant progression in gastric cancer by suppressing the TRIM21-mediated ubiquitination/degradation of STAT1 in a GTP binding-dependent modality.
Autorzy:
Zhang L; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, P. R. China.
Li Q; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, P. R. China.
Yang J; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, P. R. China.
Xu P; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, P. R. China.
Xuan Z; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, P. R. China.
Xu J; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, P. R. China.
Xu Z; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, P. R. China.; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu, 211166, P. R. China.
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Źródło:
Cancer communications (London, England) [Cancer Commun (Lond)] 2023 Jan; Vol. 43 (1), pp. 123-149. Date of Electronic Publication: 2022 Nov 09.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Glutamine gamma Glutamyltransferase 2*/metabolism
STAT1 Transcription Factor*/genetics
STAT1 Transcription Factor*/metabolism
Stomach Neoplasms*/pathology
Humans ; Calcimycin ; Cell Line, Tumor ; Guanosine Triphosphate/metabolism ; Ubiquitination
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 1286

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