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Tytuł:
The status of the human gene catalogue.
Autorzy:
Amaral P; INSPER Institute of Education and Research, Sao Paulo, Brazil.
Carbonell-Sala S; Centre for Genomic Regulation (CRG), Barcelona, Spain.
De La Vega FM; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA.; Tempus Labs, Chicago, IL, USA.
Faial T; Nature Genetics, San Francisco, CA, USA.
Frankish A; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK.
Gingeras T; Department of Functional Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Guigo R; Centre for Genomic Regulation (CRG), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Harrow JL; Centre for Genomics Research, Discovery Sciences, AstraZeneca, Royston, UK.
Hatzigeorgiou AG; Department of Computer Science and Biomedical Informatics, Universithy of Thessaly, Lamia, Greece.; Hellenic Pasteur Institute, Athens, Greece.
Johnson R; School of Biology and Environmental Science, University College Dublin, Dublin, Ireland.; Conway Institute of Biomedical and Biomolecular Research, University College Dublin, Dublin, Ireland.; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Murphy TD; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Pertea M; Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
Pruitt KD; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Pujar S; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Takahashi H; Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Ulitsky I; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel.
Varabyou A; Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA.; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
Wells CA; Stem Cell Systems, Department of Anatomy and Physiology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia.
Yandell M; Departent of Human Genetics, Utah Center for Genetic Discovery, University of Utah, Salt Lake City, UT, USA.
Carninci P; Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. .; Human Technopole, Milan, Italy. .
Salzberg SL; Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA. .; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. .; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA. .; Department of Biostatistics, Johns Hopkins University, Baltimore, MD, USA. .
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Źródło:
Nature [Nature] 2023 Oct; Vol. 622 (7981), pp. 41-47. Date of Electronic Publication: 2023 Oct 04.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Genome, Human*/genetics
Molecular Sequence Annotation*/standards
Molecular Sequence Annotation*/trends
Protein Isoforms*/genetics
Genes*
Humans ; Human Genome Project ; Pseudogenes ; RNA/genetics
Czasopismo naukowe
Tytuł:
Isoform alterations in the ubiquitination machinery impacting gastrointestinal malignancies.
Autorzy:
Kasturirangan S; Departments of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA.
Nancarrow DJ; Surgery - Section of Thoracic Surgery, University of Michigan, Ann Arbor, MI, 48109, USA.
Shah A; Departments of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA.; Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Lagisetty KH; Surgery - Section of Thoracic Surgery, University of Michigan, Ann Arbor, MI, 48109, USA.
Lawrence TS; Departments of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA.
Beer DG; Surgery - Section of Thoracic Surgery, University of Michigan, Ann Arbor, MI, 48109, USA.
Ray D; Departments of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA. .
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Źródło:
Cell death & disease [Cell Death Dis] 2024 Mar 08; Vol. 15 (3), pp. 194. Date of Electronic Publication: 2024 Mar 08.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Gastrointestinal Neoplasms*/genetics
Humans ; Ubiquitination ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Carcinogenesis ; Tumor Suppressor Proteins/metabolism ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł:
Familial Dilated Cardiomyopathy: A Novel MED9 Short Isoform Identification.
Autorzy:
Franzese M; IRCCS SYNLAB SDN, 80143 Naples, Italy.
Zanfardino M; IRCCS SYNLAB SDN, 80143 Naples, Italy.
Soricelli A; IRCCS SYNLAB SDN, 80143 Naples, Italy.; Department of Exercise and Wellness Sciences, University of Naples Parthenope, 80133 Naples, Italy.
Coppola A; Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania Luigi Vanvitelli, 81100 Naples, Italy.
Maiello C; Department of Cardiothoracic Science, U.O.S.D. of Heart Transplantation, Monaldi Hospital, 80131 Naples, Italy.
Salvatore M; IRCCS SYNLAB SDN, 80143 Naples, Italy.
Schiano C; Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania Luigi Vanvitelli, 81100 Naples, Italy.
Napoli C; IRCCS SYNLAB SDN, 80143 Naples, Italy.; Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania Luigi Vanvitelli, 81100 Naples, Italy.; Clinical Department of Internal Medicine and Specialistic Units, Division of Clinical Immunology, Immunohematology, Transfusion Medicine and Transplant Immunology (SIMT), Azienda Universitaria Policlinico (AOU), 80131 Naples, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 06; Vol. 25 (5). Date of Electronic Publication: 2024 Mar 06.
Typ publikacji:
Journal Article
MeSH Terms:
Cardiomyopathy, Dilated*/genetics
Cardiomyopathy, Dilated*/metabolism
Mediator Complex*/genetics
Mediator Complex*/metabolism
Humans ; Heart Transplantation ; Protein Isoforms/genetics ; Protein Isoforms/metabolism
Czasopismo naukowe
Tytuł:
Autophagy-dependent alternative splicing of ribosomal protein S24 produces a more stable isoform that aids in hypoxic cell survival.
Autorzy:
Kerry J; Department of Molecular and Cellular Biology, University of Guelph, Canada.
Specker EJ; Department of Molecular and Cellular Biology, University of Guelph, Canada.
Mizzoni M; Department of Molecular and Cellular Biology, University of Guelph, Canada.
Brumwell A; Department of Molecular and Cellular Biology, University of Guelph, Canada.
Fell L; Department of Molecular and Cellular Biology, University of Guelph, Canada.
Goodbrand J; Department of Molecular and Cellular Biology, University of Guelph, Canada.
Rosen MN; Department of Molecular and Cellular Biology, University of Guelph, Canada.
Uniacke J; Department of Molecular and Cellular Biology, University of Guelph, Canada.
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Źródło:
FEBS letters [FEBS Lett] 2024 Mar; Vol. 598 (5), pp. 503-520. Date of Electronic Publication: 2024 Jan 28.
Typ publikacji:
Journal Article
MeSH Terms:
Alternative Splicing*
Hypoxia*
Humans ; Cell Survival/genetics ; Cell Line, Tumor ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Cell Hypoxia/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Ribosomal Proteins/genetics ; Ribosomal Proteins/metabolism ; Autophagy/genetics
Czasopismo naukowe
Tytuł:
Mouse transient receptor potential melastatin 2 (TRPM2) isoform 7 attenuates full-length mouse TRPM2 activity through reductions in its expression by targeting it to ER-associated degradation.
Autorzy:
Yamamoto S; Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan.
Kiyatake N; Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan.
Kaneko A; Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan.
Shimamura M; Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan.
Yoshida T; Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan.
Shimizu S; Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan.
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Źródło:
Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2024 Mar; Vol. 29 (3), pp. 254-269. Date of Electronic Publication: 2024 Jan 21.
Typ publikacji:
Journal Article
MeSH Terms:
TRPM Cation Channels*/genetics
TRPM Cation Channels*/metabolism
Humans ; Mice ; Animals ; Endoplasmic Reticulum-Associated Degradation ; HEK293 Cells ; Oxidative Stress ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Calcium/metabolism
Czasopismo naukowe
Tytuł:
The effects of TGF-β1 and IFN-α2b on decorin, decorin isoforms and type I collagen in hypertrophic scar dermal fibroblasts.
Autorzy:
Eremenko EE; Department of Surgery, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Kwan PO; Department of Surgery, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Ding J; Department of Surgery, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Ghosh S; Department of Medical Oncology/Department of Mathematical and Statistical Sciences, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Tredget EE; Department of Surgery, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
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Źródło:
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society [Wound Repair Regen] 2024 Mar-Apr; Vol. 32 (2), pp. 135-145. Date of Electronic Publication: 2024 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Collagen Type I*/metabolism
Cicatrix, Hypertrophic*/pathology
Interferon alpha-2*
Humans ; Transforming Growth Factor beta1/metabolism ; Decorin/metabolism ; Wound Healing/physiology ; Collagen/metabolism ; Interferon-alpha/pharmacology ; Interferon-alpha/metabolism ; Fibroblasts/metabolism ; Protein Isoforms/metabolism ; Protein Isoforms/pharmacology ; RNA, Messenger/metabolism ; Cells, Cultured
Czasopismo naukowe
Tytuł:
A novel crosstalk between Nrf2 and Smad2/3 bridged by two nuanced Keap1 isoforms with their divergent effects on these distinct family transcription factors.
Autorzy:
Chen F; College of Bioengineering and Graduate School, Chongqing University, No. 174 Shazheng Street, Shapingba District, Chongqing, 40044, China; Chongqing University Jiangjin Hospital, School of Medicine, Chongqing University, No. 725 Jiangzhou Avenue, Dingshan Street, Jiangjin District, Chongqing, 402262, China; The Laboratory of Cell Biochemistry and Topogenetic Regulation, College of Bioengineering and Faculty of Medical Sciences, Chongqing University, No. 174 Shazheng Street, Shapingba District, Chongqing, 40044, China.
Wang Q; College of Bioengineering and Graduate School, Chongqing University, No. 174 Shazheng Street, Shapingba District, Chongqing, 40044, China; Chongqing University Jiangjin Hospital, School of Medicine, Chongqing University, No. 725 Jiangzhou Avenue, Dingshan Street, Jiangjin District, Chongqing, 402262, China; The Laboratory of Cell Biochemistry and Topogenetic Regulation, College of Bioengineering and Faculty of Medical Sciences, Chongqing University, No. 174 Shazheng Street, Shapingba District, Chongqing, 40044, China.
Xiao M; College of Bioengineering and Graduate School, Chongqing University, No. 174 Shazheng Street, Shapingba District, Chongqing, 40044, China; The Laboratory of Cell Biochemistry and Topogenetic Regulation, College of Bioengineering and Faculty of Medical Sciences, Chongqing University, No. 174 Shazheng Street, Shapingba District, Chongqing, 40044, China.
Lou D; Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, 400067, China.
Wufur R; College of Bioengineering and Graduate School, Chongqing University, No. 174 Shazheng Street, Shapingba District, Chongqing, 40044, China; Chongqing University Jiangjin Hospital, School of Medicine, Chongqing University, No. 725 Jiangzhou Avenue, Dingshan Street, Jiangjin District, Chongqing, 402262, China; The Laboratory of Cell Biochemistry and Topogenetic Regulation, College of Bioengineering and Faculty of Medical Sciences, Chongqing University, No. 174 Shazheng Street, Shapingba District, Chongqing, 40044, China.
Hu S; College of Bioengineering and Graduate School, Chongqing University, No. 174 Shazheng Street, Shapingba District, Chongqing, 40044, China; The Laboratory of Cell Biochemistry and Topogenetic Regulation, College of Bioengineering and Faculty of Medical Sciences, Chongqing University, No. 174 Shazheng Street, Shapingba District, Chongqing, 40044, China.
Zhang Z; Laboratory of Neuroscience, Institute of Cognitive Neuroscience and School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, England, United Kingdom.
Wang Y; College of Bioengineering and Graduate School, Chongqing University, No. 174 Shazheng Street, Shapingba District, Chongqing, 40044, China.
Zhang Y; Chongqing University Jiangjin Hospital, School of Medicine, Chongqing University, No. 725 Jiangzhou Avenue, Dingshan Street, Jiangjin District, Chongqing, 402262, China; The Laboratory of Cell Biochemistry and Topogenetic Regulation, College of Bioengineering and Faculty of Medical Sciences, Chongqing University, No. 174 Shazheng Street, Shapingba District, Chongqing, 40044, China. Electronic address: .
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Źródło:
Free radical biology & medicine [Free Radic Biol Med] 2024 Mar; Vol. 213, pp. 190-207. Date of Electronic Publication: 2024 Jan 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Transforming Growth Factor beta1*/metabolism
NF-E2-Related Factor 2*/genetics
NF-E2-Related Factor 2*/metabolism
Kelch-Like ECH-Associated Protein 1/genetics ; Kelch-Like ECH-Associated Protein 1/metabolism ; Signal Transduction ; Protein Isoforms/genetics ; Protein Isoforms/metabolism
Czasopismo naukowe
Tytuł:
Sustained PGC-1α2 or PGC-1α3 expression induces astrocyte dysfunction and degeneration.
Autorzy:
Nunes MJ; Department of Pharmaceutical Sciences and Medicines, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
Carvalho AN; Department of Pharmaceutical Sciences and Medicines, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
Sá-Lemos C; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
Colaço M; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
Cervenka I; Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, Stockholm, Sweden.
Ciraci V; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
Santos SG; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
Ribeiro MM; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
Castanheira M; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
Jannig PR; Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, Stockholm, Sweden.
Gama MJ; Department of Pharmaceutical Sciences and Medicines, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
Castro-Caldas M; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal; UCIBIO, Department of Life Sciences, NOVA School of Science and Technology, Universidade NOVA de Lisboa, Caparica, Portugal.
Rodrigues CMP; Department of Pharmaceutical Sciences and Medicines, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
Rodrigues E; Department of Pharmaceutical Sciences and Medicines, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
Ruas JL; Department of Pharmaceutical Sciences and Medicines, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal; Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, Stockholm, Sweden. Electronic address: .
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Źródło:
European journal of cell biology [Eur J Cell Biol] 2024 Mar; Vol. 103 (1), pp. 151377. Date of Electronic Publication: 2023 Nov 19.
Typ publikacji:
Journal Article
MeSH Terms:
Astrocytes*/metabolism
Transcription Factors*/genetics
Transcription Factors*/metabolism
Mice ; Animals ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Dopamine/metabolism ; Brain/metabolism ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism
Czasopismo naukowe
Tytuł:
Galectin-8 modulates human osteoclast activity partly through isoform-specific interactions.
Autorzy:
Roy M; https://ror.org/00kybxq39 Division of Rheumatology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Canada.
Mbous Nguimbus L; https://ror.org/00kybxq39 Division of Rheumatology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Canada.
Badiane PY; https://ror.org/00kybxq39 Division of Rheumatology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Canada.
Goguen-Couture V; https://ror.org/00kybxq39 Division of Rheumatology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Canada.
Degrandmaison J; https://ror.org/00kybxq39 Division of Rheumatology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Canada.
Parent JL; https://ror.org/00kybxq39 Division of Rheumatology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Canada.
Brunet MA; https://ror.org/00kybxq39 Department of Paediatrics, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Canada.
Roux S; https://ror.org/00kybxq39 Division of Rheumatology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Canada .
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Źródło:
Life science alliance [Life Sci Alliance] 2024 Feb 23; Vol. 7 (5). Date of Electronic Publication: 2024 Feb 23 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Bone Resorption*/metabolism
Galectins*/genetics
Galectins*/metabolism
Osteoclasts*/metabolism
Humans ; Chloride Channels/metabolism ; Chromatography, Liquid ; HEK293 Cells ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Proteomics ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł:
Deep-Learning Uncovers certain CCM Isoforms as Transcription Factors.
Autorzy:
Croft J; Department of Molecular & Translational Medicine (MTM), Texas Tech University Health Science Center El Paso (TTUHSCEP), El Paso, TX 79905, USA.
Gao L; Department of Computer Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Sheng V; Department of Computer Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Zhang J; Department of Molecular & Translational Medicine (MTM), Texas Tech University Health Science Center El Paso (TTUHSCEP), El Paso, TX 79905, USA.
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Źródło:
Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2024 Feb 21; Vol. 29 (2), pp. 75.
Typ publikacji:
Journal Article
MeSH Terms:
Hemangioma, Cavernous, Central Nervous System*/genetics
Deep Learning*
Humans ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Transcription Factors/metabolism ; Receptors, Progesterone/metabolism ; Carrier Proteins/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism
Czasopismo naukowe
Tytuł:
Identification of CD160-TM as a tumor target on triple negative breast cancers: possible therapeutic applications.
Autorzy:
Scheffges C; INSERM U976, HIPI, Team 1, 75010, Paris, France.; Université Paris Cité, IRSL, 75010, Paris, France.; Alderaan Biotechnology, 75005, Paris, France.
Devy J; UMR CNRS/URCA 7369, MEDyC, Université de Reims-Champagne-Ardennes, 51100, Reims, France.
Giustiniani J; INSERM U955, 94000, Créteil, France.
Francois S; Alderaan Biotechnology, 75005, Paris, France.
Cartier L; Département de Recherche, Institut Godinot, 51100, Reims, France.; UR7509, IRMAIC, Université de Reims-Champagne-Ardennes, 51097, Reims, France.
Merrouche Y; Département de Recherche, Institut Godinot, 51100, Reims, France.; UR7509, IRMAIC, Université de Reims-Champagne-Ardennes, 51097, Reims, France.
Foussat A; Alderaan Biotechnology, 75005, Paris, France.
Potteaux S; UR7509, IRMAIC, Université de Reims-Champagne-Ardennes, 51097, Reims, France.
Bensussan A; INSERM U976, HIPI, Team 1, 75010, Paris, France.; Université Paris Cité, IRSL, 75010, Paris, France.
Marie-Cardine A; INSERM U976, HIPI, Team 1, 75010, Paris, France. .; Université Paris Cité, IRSL, 75010, Paris, France. .
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Źródło:
Breast cancer research : BCR [Breast Cancer Res] 2024 Feb 15; Vol. 26 (1), pp. 28. Date of Electronic Publication: 2024 Feb 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Triple Negative Breast Neoplasms*/therapy
Triple Negative Breast Neoplasms*/drug therapy
Antineoplastic Agents*/therapeutic use
Humans ; Animals ; Mice ; GPI-Linked Proteins/genetics ; Cell Line ; Killer Cells, Natural ; Protein Isoforms/metabolism ; Protein Isoforms/therapeutic use ; Cell Line, Tumor ; Receptors, Immunologic/metabolism ; Receptors, Immunologic/therapeutic use ; Antigens, CD/metabolism
Czasopismo naukowe
Tytuł:
Integrative Epigenetic and Molecular Analysis Reveals a Novel Promoter for a New Isoform of the Transcription Factor TEAD4.
Autorzy:
Rashidiani S; Institute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, 7624 Pécs, Hungary.
Mamo G; Institute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, 7624 Pécs, Hungary.
Farkas B; Institute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, 7624 Pécs, Hungary.
Szabadi A; Institute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, 7624 Pécs, Hungary.; Department of Dentistry, Oral and Maxillofacial Surgery, Medical School, University of Pécs, 7623 Pécs, Hungary.
Farkas B; Department of Obstetrics and Gynecology, Medical School, University of Pécs, 7624 Pécs, Hungary.; National Laboratory of Human Reproduction, University of Pécs, 7624 Pécs, Hungary.
Uszkai V; Department of Obstetrics and Gynecology, Medical School, University of Pécs, 7624 Pécs, Hungary.
Császár A; Department of Obstetrics and Gynecology, Medical School, University of Pécs, 7624 Pécs, Hungary.
Brandt B; Department of Medical Biology and Central Electron Microscope Laboratory, Medical School, University of Pécs, 7624 Pécs, Hungary.
Kovács K; Department of Obstetrics and Gynecology, Medical School, University of Pécs, 7624 Pécs, Hungary.; National Laboratory of Human Reproduction, University of Pécs, 7624 Pécs, Hungary.
Pap M; Department of Medical Biology and Central Electron Microscope Laboratory, Medical School, University of Pécs, 7624 Pécs, Hungary.
Rauch TA; Institute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, 7624 Pécs, Hungary.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 13; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 13.
Typ publikacji:
Journal Article
MeSH Terms:
DNA-Binding Proteins*/metabolism
TEA Domain Transcription Factors*/genetics
Transcription Factors*/metabolism
Promoter Regions, Genetic*
Female ; Humans ; Pregnancy ; DNA ; Epigenesis, Genetic ; Protein Isoforms/genetics ; Protein Isoforms/metabolism
Czasopismo naukowe
Tytuł:
All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines.
Autorzy:
Tian LY; Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.; Beijing Key Surgical Basic Research Laboratory of Liver Cirrhosis and Liver Cancer, Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing 100044, China.
Smit DJ; Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
Popova NV; Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
Horn S; Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Velasquez LN; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Huber S; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Jücker M; Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 11; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 11.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/metabolism
Liver Neoplasms*/genetics
Liver Neoplasms*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Humans ; Cell Line, Tumor ; Lactic Acid/metabolism ; Oxidoreductases ; Oxygen/metabolism ; Phosphatidylinositol 3-Kinases ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Pyruvates
Czasopismo naukowe
Tytuł:
Alternative splicing and related RNA binding proteins in human health and disease.
Autorzy:
Tao Y; Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200000, Shanghai, China.; Shanghai Bone Tumor Institution, 200000, Shanghai, China.
Zhang Q; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, 200000, Shanghai, China.
Wang H; Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200000, Shanghai, China.; Shanghai Bone Tumor Institution, 200000, Shanghai, China.
Yang X; Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200000, Shanghai, China.; Shanghai Bone Tumor Institution, 200000, Shanghai, China.
Mu H; Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200000, Shanghai, China. dr_.; Shanghai Bone Tumor Institution, 200000, Shanghai, China. dr_.
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Źródło:
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2024 Feb 02; Vol. 9 (1), pp. 26. Date of Electronic Publication: 2024 Feb 02.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alternative Splicing*/genetics
Neoplasms*/genetics
Humans ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł:
On the genetic basis of tail-loss evolution in humans and apes.
Autorzy:
Xia B; Institute for Computational Medicine, NYU Langone Health, New York, NY, USA. .; Institute for Systems Genetics, NYU Langone Health, New York, NY, USA. .; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. .; Society of Fellows, Harvard University, Cambridge, MA, USA. .
Zhang W; Institute for Systems Genetics, NYU Langone Health, New York, NY, USA.
Zhao G; Institute for Computational Medicine, NYU Langone Health, New York, NY, USA.; Institute for Systems Genetics, NYU Langone Health, New York, NY, USA.
Zhang X; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, Pennsylvania State University, University Park, PA, USA.
Bai J; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Brosh R; Institute for Systems Genetics, NYU Langone Health, New York, NY, USA.
Wudzinska A; Institute for Systems Genetics, NYU Langone Health, New York, NY, USA.
Huang E; Institute for Systems Genetics, NYU Langone Health, New York, NY, USA.
Ashe H; Institute for Systems Genetics, NYU Langone Health, New York, NY, USA.
Ellis G; Institute for Systems Genetics, NYU Langone Health, New York, NY, USA.
Pour M; Institute for Computational Medicine, NYU Langone Health, New York, NY, USA.; Institute for Systems Genetics, NYU Langone Health, New York, NY, USA.
Zhao Y; Institute for Systems Genetics, NYU Langone Health, New York, NY, USA.
Coelho C; Institute for Systems Genetics, NYU Langone Health, New York, NY, USA.
Zhu Y; Institute for Systems Genetics, NYU Langone Health, New York, NY, USA.
Miller A; Department of Neuroscience and Physiology, NYU Langone Health, New York, NY, USA.
Dasen JS; Department of Neuroscience and Physiology, NYU Langone Health, New York, NY, USA.
Maurano MT; Institute for Systems Genetics, NYU Langone Health, New York, NY, USA.; Department of Pathology, NYU Langone Health, New York, NY, USA.
Kim SY; Department of Pathology, NYU Langone Health, New York, NY, USA.
Boeke JD; Institute for Systems Genetics, NYU Langone Health, New York, NY, USA. .; Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA. .; Department of Biomedical Engineering, NYU Tandon School of Engineering, Brooklyn, NY, USA. .
Yanai I; Institute for Computational Medicine, NYU Langone Health, New York, NY, USA. .; Institute for Systems Genetics, NYU Langone Health, New York, NY, USA. .; Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA. .
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Źródło:
Nature [Nature] 2024 Feb; Vol. 626 (8001), pp. 1042-1048. Date of Electronic Publication: 2024 Feb 28.
Typ publikacji:
Journal Article
MeSH Terms:
Alternative Splicing*/genetics
Evolution, Molecular*
Hominidae*/anatomy & histology
Hominidae*/genetics
T-Box Domain Proteins*/deficiency
T-Box Domain Proteins*/genetics
T-Box Domain Proteins*/metabolism
Tail*/anatomy & histology
Tail*/embryology
Animals ; Humans ; Mice ; Alu Elements/genetics ; Disease Models, Animal ; Genome/genetics ; Introns/genetics ; Neural Tube Defects/genetics ; Neural Tube Defects/metabolism ; Phenotype ; Protein Isoforms/deficiency ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Exons/genetics
Czasopismo naukowe
Tytuł:
Apolipoprotein E isoforms and their Cys-thiol modifications impact LRP1-mediated metabolism of triglyceride-rich lipoproteins.
Autorzy:
Matsuura H; Department of Clinical Laboratory Investigation, Graduate School of Medicine, Shinshu University, Matsumoto, Japan.
Akahane S; Department of Clinical Laboratory Investigation, Graduate School of Medicine, Shinshu University, Matsumoto, Japan.
Kaido T; Department of Clinical Laboratory Investigation, Graduate School of Medicine, Shinshu University, Matsumoto, Japan.; Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan.
Kamijo T; Department of Clinical Laboratory Investigation, Graduate School of Medicine, Shinshu University, Matsumoto, Japan.; Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan.
Sakamoto K; Department of Laboratory Medicine, University of Yamanashi Hospital, Japan.
Yamauchi K; Department of Clinical Laboratory Investigation, Graduate School of Medicine, Shinshu University, Matsumoto, Japan.; Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University, Matsumoto, Japan.
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Źródło:
FEBS letters [FEBS Lett] 2024 Feb; Vol. 598 (3), pp. 347-362. Date of Electronic Publication: 2024 Jan 27.
Typ publikacji:
Journal Article
MeSH Terms:
Sulfhydryl Compounds*
Apolipoproteins E*/metabolism
Apolipoprotein E2/metabolism ; Apolipoprotein E3/genetics ; Apolipoprotein E3/metabolism ; Apolipoprotein E4/genetics ; Apolipoprotein E4/metabolism ; Triglycerides/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Carrier Proteins
Czasopismo naukowe
Tytuł:
cloudrnaSPAdes: isoform assembly using bulk barcoded RNA sequencing data.
Autorzy:
Meleshko D; Tri-Institutional Computational Biology & Medicine Program, Weill Cornell Medicine of Cornell University, New York, NY 10021, United States.; Department of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, United States.
Prjbelski AD; Department of Computer Science, University of Helsinki, Helsinki 00014, Finland.
Raiko M; Center for Algorithmic Biotechnology, Institute for Translational Biomedicine, St Petersburg State University, St Petersburg 199004, Russia.
Tomescu AI; Department of Computer Science, University of Helsinki, Helsinki 00014, Finland.
Tilgner H; Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10021, United States.; Center for Neurogenetics, Weill Cornell Medicine, New York, NY 10021, United States.
Hajirasouliha I; Department of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, United States.; Englander Institute for Precision Medicine, The Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, United States.
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Źródło:
Bioinformatics (Oxford, England) [Bioinformatics] 2024 Feb 01; Vol. 40 (2).
Typ publikacji:
Journal Article
MeSH Terms:
RNA*/genetics
Genomics*/methods
Humans ; Sequence Analysis, RNA/methods ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA-Seq ; High-Throughput Nucleotide Sequencing ; Transcriptome
Czasopismo naukowe
Tytuł:
The PTB and PRR domains of numb regulate neurite outgrowth by influencing voltage-gated calcium channel expression and kinetics.
Autorzy:
Wang G; International-Joint Lab for Non-Invasive Neural Modulation of Henan Province, Department of Physiology and Pathophysiology, Xinxiang Medical University, Xinxiang 453003, China; School of Nursing, Xinxiang Medical University, Xinxiang 453003, China.
Zhang Z; International-Joint Lab for Non-Invasive Neural Modulation of Henan Province, Department of Physiology and Pathophysiology, Xinxiang Medical University, Xinxiang 453003, China; The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang 453003, China.
Li J; International-Joint Lab for Non-Invasive Neural Modulation of Henan Province, Department of Physiology and Pathophysiology, Xinxiang Medical University, Xinxiang 453003, China.
Han J; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China.
Lu C; International-Joint Lab for Non-Invasive Neural Modulation of Henan Province, Department of Physiology and Pathophysiology, Xinxiang Medical University, Xinxiang 453003, China. Electronic address: .
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Źródło:
Brain research bulletin [Brain Res Bull] 2024 Feb; Vol. 207, pp. 110876. Date of Electronic Publication: 2024 Jan 10.
Typ publikacji:
Journal Article
MeSH Terms:
Membrane Proteins*/genetics
Membrane Proteins*/metabolism
Neurons*/metabolism
Rats ; Animals ; Calcium Channels/genetics ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Isoforms/pharmacology ; Neuronal Outgrowth ; Calcium/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism
Czasopismo naukowe
Tytuł:
The transcription factor NF-YA is crucial for neural progenitor maintenance during brain development.
Autorzy:
Yamanaka T; Department of Neuroscience of Disease, Brain Research Institute, Niigata University, Niigata, Japan; Laboratory of Structural Neuropathology, Doshisha University Graduate School of Brain Science, Kyoto, Japan; Laboratory for Molecular Mechanisms of Brain Development, RIKEN Center for Brain Science, Saitama, Japan; Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan. Electronic address: .
Kurosawa M; Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Yoshida A; Laboratory for Molecular Mechanisms of Brain Development, RIKEN Center for Brain Science, Saitama, Japan.
Shimogori T; Laboratory for Molecular Mechanisms of Brain Development, RIKEN Center for Brain Science, Saitama, Japan.
Hiyama A; Laboratory of Structural Neuropathology, Doshisha University Graduate School of Brain Science, Kyoto, Japan.
Maity SN; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Hattori N; Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Matsui H; Department of Neuroscience of Disease, Brain Research Institute, Niigata University, Niigata, Japan.
Nukina N; Laboratory of Structural Neuropathology, Doshisha University Graduate School of Brain Science, Kyoto, Japan; Laboratory for Molecular Mechanisms of Brain Development, RIKEN Center for Brain Science, Saitama, Japan; Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2024 Feb; Vol. 300 (2), pp. 105629. Date of Electronic Publication: 2024 Jan 08.
Typ publikacji:
Journal Article
MeSH Terms:
CCAAT-Binding Factor*/genetics
CCAAT-Binding Factor*/metabolism
Cerebral Cortex*/cytology
Cerebral Cortex*/growth & development
Cerebral Cortex*/metabolism
Animals ; Mice ; Gene Expression Regulation ; Neurogenesis ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
Intron retention as a productive mechanism in human MAPT: RNA species generated by retention of intron 3.
Autorzy:
Ruiz-Gabarre D; Anatomy, Histology and Neuroscience Department, School of Medicine, Universidad Autónoma de Madrid (UAM), 28029, Madrid, Spain; Centro de Biología Molecular Severo Ochoa (UAM-CSIC), 28049, Madrid, Spain; Graduate Programa in Neuroscience, Universidad Autónoma de Madrid (UAM), 28029, Madrid, Spain.
Vallés-Saiz L; Centro de Biología Molecular Severo Ochoa (UAM-CSIC), 28049, Madrid, Spain.
Carnero-Espejo A; Anatomy, Histology and Neuroscience Department, School of Medicine, Universidad Autónoma de Madrid (UAM), 28029, Madrid, Spain; Graduate Programa in Neuroscience, Universidad Autónoma de Madrid (UAM), 28029, Madrid, Spain.
Ferrer I; Networking Research Centre on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029, Madrid, Spain; Department of Pathology and Experimental Therapeutics, University of Barcelona, 08907, Barcelona, Spain; Bellvitge University Hospital, IDIBELL (Bellvitge Biomedical Research Centre), 08908, Barcelona, Spain; Institute of Neurosciences, University of Barcelona, 08035, Barcelona, Spain.
Hernández F; Centro de Biología Molecular Severo Ochoa (UAM-CSIC), 28049, Madrid, Spain.
Garcia-Escudero R; Biomedical Oncology Unit, CIEMAT, 28040, Madrid, Spain; Research Institute Hospital 12 de Octubre (imas12), 28041, Madrid, Spain; Networking Research Centre on Cancer (CIBERONC), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Ávila J; Centro de Biología Molecular Severo Ochoa (UAM-CSIC), 28049, Madrid, Spain; Networking Research Centre on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029, Madrid, Spain. Electronic address: .
García-Escudero V; Anatomy, Histology and Neuroscience Department, School of Medicine, Universidad Autónoma de Madrid (UAM), 28029, Madrid, Spain; Graduate Programa in Neuroscience, Universidad Autónoma de Madrid (UAM), 28029, Madrid, Spain; Networking Research Centre on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029, Madrid, Spain; Institute for Molecular Biology-IUBM (Universidad Autónoma de Madrid), 28049, Madrid, Spain. Electronic address: .
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Źródło:
EBioMedicine [EBioMedicine] 2024 Feb; Vol. 100, pp. 104953. Date of Electronic Publication: 2024 Jan 05.
Typ publikacji:
Journal Article
MeSH Terms:
RNA*/genetics
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Humans ; Introns/genetics ; tau Proteins/genetics ; tau Proteins/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism
Czasopismo naukowe

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