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Tytuł :
Detection of an enzyme isomechanism by means of the kinetics of covalent inhibition.
Autorzy :
Adediran SA; Department of Chemistry, Wesleyan University, Middletown, CT 06459, USA.
Morrison MJ; Department of Chemistry, Wesleyan University, Middletown, CT 06459, USA.
Pratt RF; Department of Chemistry, Wesleyan University, Middletown, CT 06459, USA. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Proteins and proteomics [Biochim Biophys Acta Proteins Proteom] 2021 Sep; Vol. 1869 (9), pp. 140681. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enzyme Inhibitors/*metabolism
Enzymes/*metabolism
Protein Isoforms/*metabolism
Acylation ; Cephalosporins/chemistry ; Deuterium/chemistry ; Enzyme Inhibitors/chemistry ; Enzymes/chemistry ; Hydrolysis ; Kinetics ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/chemistry ; Solvents ; Substrate Specificity ; beta-Lactamases/chemistry ; beta-Lactamases/metabolism
Czasopismo naukowe
Tytuł :
Translation of human Δ133p53 mRNA and its targeting by antisense oligonucleotides complementary to the 5'-terminal region of this mRNA.
Autorzy :
Żydowicz-Machtel P; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Dutkiewicz M; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Swiatkowska A; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Gurda-Woźna D; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Ciesiołka J; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
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Źródło :
PloS one [PLoS One] 2021 Sep 07; Vol. 16 (9), pp. e0256938. Date of Electronic Publication: 2021 Sep 07 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Oligonucleotides, Antisense/*pharmacology
Protein Biosynthesis/*drug effects
Protein Isoforms/*genetics
Tumor Suppressor Protein p53/*genetics
Cell Survival/drug effects ; Codon, Initiator/antagonists & inhibitors ; HCT116 Cells ; Humans ; Introns/genetics ; Protein Isoforms/antagonists & inhibitors ; RNA, Messenger/antagonists & inhibitors ; Transcription Initiation Site/drug effects ; Tumor Suppressor Protein p53/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Systematic detection of functional proteoform groups from bottom-up proteomic datasets.
Autorzy :
Bludau I; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
Frank M; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.; Department of Molecular Genetics, University of Toronto, Toronto, Canada.; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada.; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
Dörig C; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
Cai Y; Department of Molecular Genetics, University of Toronto, Toronto, Canada.; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada.
Heusel M; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.; Division of Infection Medicine (BMC), Department of Clinical Sciences, Lund University, Lund, Sweden.
Rosenberger G; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.; Columbia University, New York, NY, USA.
Picotti P; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
Collins BC; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.; School of Biological Sciences, Queen's University Belfast, Belfast, UK.
Röst H; Department of Molecular Genetics, University of Toronto, Toronto, Canada. .; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada. .
Aebersold R; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland. .; Faculty of Science, University of Zurich, Zurich, Switzerland. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 21; Vol. 12 (1), pp. 3810. Date of Electronic Publication: 2021 Jun 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Isoforms/*analysis
Proteomics/*methods
Algorithms ; Animals ; Benchmarking ; Humans ; Mice ; Peptides/analysis ; Peptides/metabolism ; Protein Isoforms/metabolism ; Proteomics/standards ; Tandem Mass Spectrometry ; Workflow
Czasopismo naukowe
Tytuł :
The relative abundance of wheat Rubisco activase isoforms is post-transcriptionally regulated.
Autorzy :
Perdomo JA; Lancaster Environment Centre, Lancaster University, Lancaster, LA1 4YQ, UK. .
Buchner P; Plant Biology and Crop Science Department, Rothamsted Research, Harpenden, AL5 2JQ, UK.
Carmo-Silva E; Lancaster Environment Centre, Lancaster University, Lancaster, LA1 4YQ, UK.
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Źródło :
Photosynthesis research [Photosynth Res] 2021 May; Vol. 148 (1-2), pp. 47-56. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Isoforms*
Photosynthesis/*genetics
Photosynthesis/*physiology
Plant Leaves/*metabolism
Plant Proteins/*metabolism
Ribulose-Bisphosphate Carboxylase/*metabolism
Triticum/*enzymology
Triticum/*genetics
Crops, Agricultural/enzymology ; Crops, Agricultural/genetics ; Gene Expression Regulation, Plant ; Plant Leaves/genetics ; Plant Proteins/genetics ; Ribulose-Bisphosphate Carboxylase/genetics
Czasopismo naukowe
Tytuł :
A network-based computational framework to predict and differentiate functions for gene isoforms using exon-level expression data.
Autorzy :
Wang D; Department of Biomedical Informatics, The Ohio State University, OH 43210, USA; School of Mathematics and Statistics, Wuhan University, Wuhan 430072, China; Computational Science Hubei Key Laboratory, Wuhan University, Wuhan 430072, China.
Zou X; School of Mathematics and Statistics, Wuhan University, Wuhan 430072, China; Computational Science Hubei Key Laboratory, Wuhan University, Wuhan 430072, China. Electronic address: .
Fai Au K; Department of Biomedical Informatics, The Ohio State University, OH 43210, USA. Electronic address: .
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Źródło :
Methods (San Diego, Calif.) [Methods] 2021 May; Vol. 189, pp. 54-64. Date of Electronic Publication: 2020 Jun 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Exons*
Neural Networks, Computer*
Protein Isoforms*
Software*
Computational Biology/*methods
Gene Expression Regulation ; High-Throughput Nucleotide Sequencing ; Humans ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
Alternative human eIF5A protein isoform plays a critical role in mitochondria.
Autorzy :
Pereira KD; Laboratory of Biotechnology, School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.; Institute of Biosciences, São Paulo State University (UNESP), Rio Claro, São Paulo, Brazil.
Tamborlin L; Laboratory of Biotechnology, School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.; Institute of Biosciences, São Paulo State University (UNESP), Rio Claro, São Paulo, Brazil.
de Lima TI; Department of Structural and Functional Biology, Obesity and Comorbidities Research Center, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Consonni SR; Laboratory of Cytochemistry and Immunocytochemistry, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Silveira LR; Department of Structural and Functional Biology, Obesity and Comorbidities Research Center, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Luchessi AD; Laboratory of Biotechnology, School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.; Institute of Biosciences, São Paulo State University (UNESP), Rio Claro, São Paulo, Brazil.
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Źródło :
Journal of cellular biochemistry [J Cell Biochem] 2021 May; Vol. 122 (5), pp. 549-561. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitochondria/*metabolism
Peptide Initiation Factors/*metabolism
Protein Isoforms/*metabolism
RNA-Binding Proteins/*metabolism
Apoptosis/physiology ; Humans ; Lysine/analogs & derivatives ; Lysine/metabolism ; Microscopy, Electron, Transmission ; Peptide Initiation Factors/genetics ; Protein Isoforms/genetics ; RNA-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
TREM-1 isoforms in bacterial infections: to immune modulation and beyond.
Autorzy :
Matos AO; Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Brazil.
Dantas PHDS; Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Brazil.
Silva-Sales M; Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Brazil.
Sales-Campos H; Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Brazil.
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Źródło :
Critical reviews in microbiology [Crit Rev Microbiol] 2021 May; Vol. 47 (3), pp. 290-306. Date of Electronic Publication: 2021 Jan 31.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Bacterial Infections/*immunology
Protein Isoforms/*immunology
Triggering Receptor Expressed on Myeloid Cells-1/*immunology
Animals ; Bacteria/genetics ; Bacteria/immunology ; Bacterial Infections/genetics ; Bacterial Infections/microbiology ; Biomarkers/analysis ; Humans ; Immunity ; Protein Isoforms/genetics ; Triggering Receptor Expressed on Myeloid Cells-1/genetics
Czasopismo naukowe
Tytuł :
Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms.
Autorzy :
Gogl G; Equipe Labellisee Ligue 2015, Department of Integrated Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Universite de Strasbourg, Illkirch, France. .
Tugaeva KV; A.N. Bach Institute of Biochemistry, Federal Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russia.
Eberling P; Equipe Labellisee Ligue 2015, Department of Integrated Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Universite de Strasbourg, Illkirch, France.
Kostmann C; Equipe Labellisee Ligue 2015, Department of Integrated Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Universite de Strasbourg, Illkirch, France.
Trave G; Equipe Labellisee Ligue 2015, Department of Integrated Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Universite de Strasbourg, Illkirch, France. .
Sluchanko NN; A.N. Bach Institute of Biochemistry, Federal Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russia. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 15; Vol. 12 (1), pp. 1677. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Isoforms*/metabolism
14-3-3 Proteins/*chemistry
14-3-3 Proteins/metabolism ; Amino Acid Sequence ; Crystallography, X-Ray ; Humans ; Papillomaviridae ; Phosphoproteins ; Phosphorylation ; Protein Binding
Czasopismo naukowe
Tytuł :
A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain.
Autorzy :
Joglekar A; Brain and Mind Research Institute and Center for Neurogenetics, Weill Cornell Medicine, New York, NY, USA.
Prjibelski A; Center for Algorithmic Biotechnology, Institute of Translational Biomedicine, St. Petersburg State University, St Petersburg, Russia.
Mahfouz A; Department of Human Genetics, Leiden University Medical Center, Leiden, 2333 ZC, The Netherlands.; Leiden Computational Biology Center, Leiden University Medical Center, Leiden, 2333 ZC, The Netherlands.; Delft Bioinformatics Lab, Delft University of Technology, Delft, 2628 XE, The Netherlands.
Collier P; Brain and Mind Research Institute and Center for Neurogenetics, Weill Cornell Medicine, New York, NY, USA.
Lin S; Graduate Program in Neuroscience, Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA.; Cardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Schlusche AK; Brain and Mind Research Institute and Center for Neurogenetics, Weill Cornell Medicine, New York, NY, USA.
Marrocco J; Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA.
Williams SR; 10x Genomics, Pleasanton, CA, USA.
Haase B; The Vertebrate Genomes Lab, The Rockefeller University, New York, NY, USA.
Hayes A; 10x Genomics, Pleasanton, CA, USA.
Chew JG; 10x Genomics, Pleasanton, CA, USA.
Weisenfeld NI; 10x Genomics, Pleasanton, CA, USA.
Wong MY; Brain and Mind Research Institute and Appel Alzheimer's Research Institute, Weill Cornell Medicine, New York, NY, USA.
Stein AN; School of General Studies, Columbia University, New York, NY, USA.
Hardwick SA; Brain and Mind Research Institute and Center for Neurogenetics, Weill Cornell Medicine, New York, NY, USA.; Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Hunt T; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Wang Q; Section of Bioinformatics and Systems Cardiology, University Hospital, 96120, Heidelberg, Germany.
Dieterich C; Section of Bioinformatics and Systems Cardiology, University Hospital, 96120, Heidelberg, Germany.
Bent Z; 10x Genomics, Pleasanton, CA, USA.
Fedrigo O; The Vertebrate Genomes Lab, The Rockefeller University, New York, NY, USA.
Sloan SA; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Risso D; Department of Statistical Sciences, University of Padova, Padova, Italy.
Jarvis ED; The Vertebrate Genomes Lab, The Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Flicek P; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Luo W; Brain and Mind Research Institute and Appel Alzheimer's Research Institute, Weill Cornell Medicine, New York, NY, USA.
Pitt GS; Graduate Program in Neuroscience, Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA.; Cardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Frankish A; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Smit AB; Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, The Netherlands.
Ross ME; Brain and Mind Research Institute and Center for Neurogenetics, Weill Cornell Medicine, New York, NY, USA.
Tilgner HU; Brain and Mind Research Institute and Center for Neurogenetics, Weill Cornell Medicine, New York, NY, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 19; Vol. 12 (1), pp. 463. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing/*physiology
Gene Expression Regulation, Developmental/*physiology
Hippocampus/*metabolism
Prefrontal Cortex/*metabolism
Protein Isoforms/*metabolism
Animals ; Animals, Newborn ; Computational Biology ; Female ; Hippocampus/cytology ; Hippocampus/growth & development ; Mice ; Models, Animal ; Prefrontal Cortex/cytology ; Prefrontal Cortex/growth & development ; Protein Isoforms/analysis ; Protein Isoforms/genetics ; Single-Cell Analysis/methods ; Spatial Analysis
Czasopismo naukowe
Tytuł :
Contrasting activities of estrogen receptor beta isoforms in triple negative breast cancer.
Autorzy :
Yan S; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Dey P; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Ziegler Y; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Jiao X; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.; Department of Respiration, Shenyang Chest Hospital, Liaoning Province, Shenyang, 110044, China.
Kim SH; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Katzenellenbogen JA; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.; Cancer Center, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Katzenellenbogen BS; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. .; Cancer Center, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. .
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Źródło :
Breast cancer research and treatment [Breast Cancer Res Treat] 2021 Jan; Vol. 185 (2), pp. 281-292. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*/drug therapy
Breast Neoplasms*/genetics
Estrogen Receptor beta*/genetics
Estrogen Receptor beta*/metabolism
Protein Isoforms*/genetics
Protein Isoforms*/metabolism
Triple Negative Breast Neoplasms*/drug therapy
Triple Negative Breast Neoplasms*/genetics
Humans ; Prognosis ; RNA, Messenger
Czasopismo naukowe
Tytuł :
The PKC universe keeps expanding: From cancer initiation to metastasis.
Autorzy :
Rahimova N; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Cooke M; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Medicine, Einstein Medical Center Philadelphia, Philadelphia, PA, 19141, USA.
Zhang S; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Baker MJ; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Kazanietz MG; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address: .
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Źródło :
Advances in biological regulation [Adv Biol Regul] 2020 Dec; Vol. 78, pp. 100755. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Neoplasm Metastasis*
Neoplasms/*pathology
Protein Isoforms/*metabolism
Protein Kinase C/*metabolism
Animals ; Carcinogenesis ; Diglycerides/metabolism ; Epithelial-Mesenchymal Transition ; Humans ; Mutation ; Neoplasms/enzymology ; Protein Conformation ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Kinase C/chemistry ; Protein Kinase C/genetics
Czasopismo naukowe
Tytuł :
Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity.
Autorzy :
Cote JL; Neuroscience Program, University of Michigan Medical School, Ann Arbor, MI.
Argetsinger LS; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
Flores A; Cell and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI.
Rupp AC; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI.
Cline JM; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
DeSantis LC; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
Bedard AH; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
Bagchi DP; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
Vander PB; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
Cacciaglia AM; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
Clutter ES; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
Chandrashekar G; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
MacDougald OA; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.; Cell and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI.; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI.
Myers MG Jr; Neuroscience Program, University of Michigan Medical School, Ann Arbor, MI.; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.; Cell and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI.; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI.
Carter-Su C; Neuroscience Program, University of Michigan Medical School, Ann Arbor, MI .; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.; Cell and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI.; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI.
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Źródło :
Diabetes [Diabetes] 2021 Feb; Vol. 70 (2), pp. 400-414. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*genetics
Brain/*metabolism
Obesity/*genetics
Protein Isoforms/*genetics
Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Energy Metabolism/drug effects ; Energy Metabolism/genetics ; Insulin Resistance/genetics ; Leptin/pharmacology ; Mice ; Mice, Knockout ; Obesity/metabolism ; Protein Isoforms/metabolism
Czasopismo naukowe
Tytuł :
Targeting alternative splicing by RNAi: from the differential impact on splice variants to triggering artificial pre-mRNA splicing.
Autorzy :
Fuchs A; Max Perutz Labs, Medical University of Vienna, Vienna 1030, Austria.
Riegler S; Max Perutz Labs, Medical University of Vienna, Vienna 1030, Austria.; Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences Vienna, Vienna 1190, Austria.
Ayatollahi Z; Max Perutz Labs, Medical University of Vienna, Vienna 1030, Austria.
Cavallari N; Max Perutz Labs, Medical University of Vienna, Vienna 1030, Austria.
Giono LE; Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), CONICET-Universidad de Buenos Aires, C1428EHA, Buenos Aires, Argentina.
Nimeth BA; Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences Vienna, Vienna 1190, Austria.
Mutanwad KV; Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences Vienna, Vienna 1190, Austria.
Schweighofer A; Max Perutz Labs, University of Vienna, Vienna 1030, Austria.
Lucyshyn D; Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences Vienna, Vienna 1190, Austria.
Barta A; Max Perutz Labs, Medical University of Vienna, Vienna 1030, Austria.
Petrillo E; Max Perutz Labs, Medical University of Vienna, Vienna 1030, Austria.; Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), CONICET-Universidad de Buenos Aires, C1428EHA, Buenos Aires, Argentina.
Kalyna M; Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences Vienna, Vienna 1190, Austria.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 25; Vol. 49 (2), pp. 1133-1151.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockdown Techniques*
Nonsense Mediated mRNA Decay*
RNA Interference*
Alternative Splicing/*genetics
Arabidopsis/*genetics
Arabidopsis Proteins/*genetics
Gene Expression Regulation, Plant/*genetics
Protein Isoforms/*genetics
RNA Precursors/*metabolism
RNA, Plant/*metabolism
Arabidopsis Proteins/biosynthesis ; Exons ; Genes, Plant ; HeLa Cells ; Humans ; MicroRNAs/genetics ; Plants, Genetically Modified ; Protein Isoforms/biosynthesis ; Protoplasts/metabolism ; RNA Precursors/genetics ; RNA Processing, Post-Transcriptional ; RNA, Plant/genetics ; Serine-Arginine Splicing Factors/biosynthesis ; Serine-Arginine Splicing Factors/genetics ; Transcription, Genetic ; Transfection
Czasopismo naukowe
Tytuł :
QuickIsoSeq for Isoform Quantification in Large-Scale RNA Sequencing.
Autorzy :
Gamini R; Pfizer Worldwide Research and Development, Cambridge, MA, USA.
Nakashima R; Pfizer Worldwide Research and Development, Cambridge, MA, USA.
He W; Pfizer Worldwide Research and Development, Cambridge, MA, USA.
Zhang C; Pfizer Worldwide Research and Development, Cambridge, MA, USA.
Huang Y; Pfizer Worldwide Research and Development, Cambridge, MA, USA.
Zhang Y; Pfizer Worldwide Research and Development, Cambridge, MA, USA.
Zhang B; Pfizer Worldwide Research and Development, Cambridge, MA, USA.
Zhao S; Pfizer Worldwide Research and Development, Cambridge, MA, USA. .; AbSci Inc, Vancouver, WA, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2284, pp. 135-145.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Isoforms/*genetics
RNA/*genetics
RNA-Seq/*methods
Algorithms ; Animals ; Base Sequence ; Computational Biology/methods ; Gene Expression Profiling ; Genetic Techniques ; Humans ; Organ Specificity/genetics ; Protein Isoforms/analysis ; RNA/analysis ; RNA/chemistry ; RNA, Messenger/analysis ; RNA, Messenger/chemistry ; RNA, Messenger/genetics ; Software
Czasopismo naukowe
Tytuł :
Avian Toll-like receptor 3 isoforms and evaluation of Toll-like receptor 3-mediated immune responses using knockout quail fibroblast cells.
Autorzy :
Kc M; Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, USA; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, USA.
Ngunjiri JM; Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, USA.
Lee J; Department of Animal Sciences, College of Food, Agricultural, and Environmental Sciences, The Ohio State University, Columbus, USA.
Ahn J; Department of Animal Sciences, College of Food, Agricultural, and Environmental Sciences, The Ohio State University, Columbus, USA.
Elaish M; Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, USA; Poultry Diseases Department, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt.
Ghorbani A; Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, USA; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, USA.
Abundo MEC; Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, USA; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, USA.
Lee K; Department of Animal Sciences, College of Food, Agricultural, and Environmental Sciences, The Ohio State University, Columbus, USA. Electronic address: .
Lee CW; Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, USA; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, USA. Electronic address: .
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Źródło :
Poultry science [Poult Sci] 2020 Dec; Vol. 99 (12), pp. 6513-6524. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article
MeSH Terms :
Birds*/immunology
Immunity*/immunology
Protein Isoforms*/immunology
Toll-Like Receptor 3*/chemistry
Toll-Like Receptor 3*/immunology
Animals ; Cells, Cultured ; Fibroblasts/immunology ; Poly I-C/pharmacology ; Quail/immunology
Czasopismo naukowe
Tytuł :
Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors.
Autorzy :
Brullo C; Department of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genova, Viale Benedetto XV 3, 16132, Genova, Italy.
Rapetti F; Department of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genova, Viale Benedetto XV 3, 16132, Genova, Italy.
Abbate S; Center for Nano Science and Technology @ PoliMi, Istituto Italiano di Tecnologia, via Giovanni Pascoli 70/3, 20133, Milano, Italy.
Prosdocimi T; Center for Nano Science and Technology @ PoliMi, Istituto Italiano di Tecnologia, via Giovanni Pascoli 70/3, 20133, Milano, Italy.
Torretta A; Center for Nano Science and Technology @ PoliMi, Istituto Italiano di Tecnologia, via Giovanni Pascoli 70/3, 20133, Milano, Italy.
Semrau M; Elettra Sincrotrone Trieste S.C.p.A., SS 14 - km 163,5 in AREA Science Park, 34149, Trieste, Italy.
Massa M; Department of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genova, Viale Benedetto XV 3, 16132, Genova, Italy.
Alfei S; Department of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genova, Viale Benedetto XV 3, 16132, Genova, Italy.
Storici P; Elettra Sincrotrone Trieste S.C.p.A., SS 14 - km 163,5 in AREA Science Park, 34149, Trieste, Italy.
Parisini E; Center for Nano Science and Technology @ PoliMi, Istituto Italiano di Tecnologia, via Giovanni Pascoli 70/3, 20133, Milano, Italy; Latvian Institute of Organic Synthesis, Aizkraukles 21, LV, 1006, Riga, Latvia. Electronic address: .
Bruno O; Department of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genova, Viale Benedetto XV 3, 16132, Genova, Italy. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 05; Vol. 223, pp. 113638. Date of Electronic Publication: 2021 Jun 13.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Cyclic Nucleotide Phosphodiesterases, Type 4/*metabolism
Phosphodiesterase 4 Inhibitors/*chemical synthesis
Small Molecule Libraries/*chemistry
Binding Sites ; Catalytic Domain ; Crystallography, X-Ray ; Cyclic AMP/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 4/chemistry ; Cyclic Nucleotide Phosphodiesterases, Type 4/genetics ; Humans ; Molecular Docking Simulation ; Phosphodiesterase 4 Inhibitors/chemistry ; Phosphodiesterase 4 Inhibitors/metabolism ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/metabolism ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/isolation & purification ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Novel TREM2 splicing isoform that lacks the V-set immunoglobulin domain is abundant in the human brain.
Autorzy :
Kiianitsa K; Department of Immunology, University of Washington, Seattle, Washington, USA.
Kurtz I; Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington, USA.
Beeman N; Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington, USA.
Matsushita M; Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington, USA.
Chien WM; Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington, USA.
Raskind WH; Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.; Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Medical Center, Seattle, Washington, USA.; Geriatric Research, Education and Clinical Center (GRECC), VA Puget Sound Medical Center, Seattle, Washington, USA.
Korvatska O; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Nov; Vol. 110 (5), pp. 829-837. Date of Electronic Publication: 2021 Jun 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Alternative Splicing/*physiology
Brain/*metabolism
Membrane Glycoproteins/*genetics
Membrane Glycoproteins/*metabolism
Microglia/*metabolism
Receptors, Immunologic/*genetics
Receptors, Immunologic/*metabolism
Humans ; Immunoglobulin Domains ; Phagocytosis/genetics ; Protein Isoforms/genetics ; Protein Isoforms/metabolism
Czasopismo naukowe
Tytuł :
Structural Insight into Chromatin Recognition by Multiple Domains of the Tumor Suppressor RBBP1.
Autorzy :
Gong W; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: .
Liang Q; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, 19A Yuquan Road, Shijingshan District, Beijing 100049, China.
Tong Y; Department of Chemistry & Biochemistry, University of Windsor, Windsor, Ontario N9B 3P4, Canada. Electronic address: .
Perrett S; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, 19A Yuquan Road, Shijingshan District, Beijing 100049, China. Electronic address: .
Feng Y; CAS Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China; Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China; University of Chinese Academy of Sciences, 19A Yuquan Road, Shijingshan District, Beijing 100049, China. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Oct 15; Vol. 433 (21), pp. 167224. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin/*chemistry
DNA/*chemistry
Histones/*chemistry
Retinoblastoma-Binding Protein 1/*chemistry
Amino Acid Sequence ; Binding Sites ; Chromatin/metabolism ; DNA/genetics ; DNA/metabolism ; Gene Expression ; Histones/genetics ; Histones/metabolism ; Humans ; Models, Molecular ; Nucleic Acid Conformation ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Retinoblastoma-Binding Protein 1/genetics ; Retinoblastoma-Binding Protein 1/metabolism ; Retinoblastoma-Binding Protein 2/chemistry ; Retinoblastoma-Binding Protein 2/genetics ; Retinoblastoma-Binding Protein 2/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Thermodynamics
Czasopismo naukowe
Tytuł :
Comparative structural and functional studies of low molecular weight tropomyosin isoforms, the TPM3 gene products.
Autorzy :
Marchenko MA; A.N. Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, 119071, Moscow, Russia; Department of Biochemistry, School of Biology, Moscow State University, Moscow, 119234, Russia.
Nefedova VV; A.N. Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, 119071, Moscow, Russia.
Yampolskaya DS; A.N. Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, 119071, Moscow, Russia.
Borzova VA; A.N. Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, 119071, Moscow, Russia.
Kleymenov SY; Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, 119334, Moscow, Russia.
Nabiev SR; Institute of Immunology and Physiology, Russian Academy of Sciences, Yekaterinburg, 620049, Russia.
Nikitina LV; Institute of Immunology and Physiology, Russian Academy of Sciences, Yekaterinburg, 620049, Russia.
Matyushenko AM; A.N. Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, 119071, Moscow, Russia.
Levitsky DI; A.N. Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, 119071, Moscow, Russia. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Oct 15; Vol. 710, pp. 108999. Date of Electronic Publication: 2021 Jul 30.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Tropomyosin/*chemistry
Tropomyosin/*genetics
Actins/chemistry ; Actins/metabolism ; Animals ; Humans ; In Vitro Techniques ; Molecular Weight ; Protein Folding ; Protein Interaction Domains and Motifs ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Stability ; Rabbits ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Thermodynamics ; Tropomyosin/metabolism ; Viscosity
Czasopismo naukowe
Tytuł :
Protein Aggregation and Disaggregation in Cells and Development.
Autorzy :
Fassler JS; Department of Biology, University of Iowa, Iowa City, IA 52242, United States. Electronic address: .
Skuodas S; Department of Biology, University of Iowa, Iowa City, IA 52242, United States. Electronic address: https:.
Weeks DL; Department of Biochemistry, University of Iowa, Iowa City, IA 52242, United States.
Phillips BT; Department of Biology, University of Iowa, Iowa City, IA 52242, United States. Electronic address: https:.
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Oct 15; Vol. 433 (21), pp. 167215. Date of Electronic Publication: 2021 Aug 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Protein Processing, Post-Translational*
Embryonic Development/*genetics
Gametogenesis/*genetics
Neurodegenerative Diseases/*genetics
Protein Aggregates/*genetics
Protein Aggregation, Pathological/*genetics
ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Animals ; Cell Differentiation ; Cell Proliferation ; Eukaryotic Cells/cytology ; Eukaryotic Cells/metabolism ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Humans ; Memory/physiology ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Nuclear Pore Complex Proteins/genetics ; Nuclear Pore Complex Proteins/metabolism ; Protein Aggregation, Pathological/metabolism ; Protein Aggregation, Pathological/pathology ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Signal Transduction
Czasopismo naukowe

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