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Wyszukujesz frazę ""Protein Kinases"" wg kryterium: Temat


Tytuł :
Stress-activated kinases as therapeutic targets in pancreatic cancer.
Autorzy :
Traub B; Department of General and Visceral Surgery, Ulm University Hospital, Ulm 89081, Germany.
Roth A; Department of General and Visceral Surgery, Ulm University Hospital, Ulm 89081, Germany.
Kornmann M; Department of General and Visceral Surgery, Ulm University Hospital, Ulm 89081, Germany.
Knippschild U; Department of General and Visceral Surgery, Ulm University Hospital, Ulm 89081, Germany. .
Bischof J; Department of General and Visceral Surgery, Ulm University Hospital, Ulm 89081, Germany.
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Źródło :
World journal of gastroenterology [World J Gastroenterol] 2021 Aug 14; Vol. 27 (30), pp. 4963-4984.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Pancreatic Neoplasms*/drug therapy
p38 Mitogen-Activated Protein Kinases*
Apoptosis ; Humans ; JNK Mitogen-Activated Protein Kinases ; Mitogen-Activated Protein Kinases
Czasopismo naukowe
Tytuł :
African pygmy hedgehog adenovirus: Virus replication, virus-induced cytopathogenesis and activation of mitogen-activated protein kinase signaling pathways in infected MDCK cells.
Autorzy :
Wen R; Center for Infectious Diseases Epidemiology and Prevention Research, Fuchu, Tokyo, Japan.
Ochiai H; Research Institute of Biosciences, Azabu University, Sagamihara, Kanagawa, Japan.
Uchiyama J; Laboratory of Microbiology, Azabu University, Sagamihara, Kanagawa, Japan.
Osawa N; Center for Infectious Diseases Epidemiology and Prevention Research, Fuchu, Tokyo, Japan.
Oba M; Center for Infectious Diseases Epidemiology and Prevention Research, Fuchu, Tokyo, Japan.
Katayama Y; Center for Infectious Diseases Epidemiology and Prevention Research, Fuchu, Tokyo, Japan.
Li K; Center for Infectious Diseases Epidemiology and Prevention Research, Fuchu, Tokyo, Japan.
Omatsu T; Center for Infectious Diseases Epidemiology and Prevention Research, Fuchu, Tokyo, Japan.
Tamukai K; Denenchofu Animal Hospital, Ota, Tokyo, Japan.
Suzuki K; Field Science Center, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.
Madarame H; Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University, Sagamihara, Kanagawa, Japan.
Makino S; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, USA.
Mizutani T; Center for Infectious Diseases Epidemiology and Prevention Research, Fuchu, Tokyo, Japan. Electronic address: .
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Źródło :
Research in veterinary science [Res Vet Sci] 2021 Oct; Vol. 139, pp. 152-158. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article
MeSH Terms :
Adenoviridae*/genetics
JNK Mitogen-Activated Protein Kinases*/metabolism
MAP Kinase Signaling System*
Virus Replication*
Animals ; Apoptosis ; Dogs ; Hedgehogs/metabolism ; Madin Darby Canine Kidney Cells ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Doxycycline ameliorates autophagy by inhibiting p38 MAPK in cardiac myocytes.
Autorzy :
Hou LJ; The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan City People's Hospital, Qingyuan, 511518, Guangdong, China.
Xie MY; Collaborative Innovation Center of Plant Pest Management and Bioenvironmental Health Application Technology, Guangdong Eco-Engineering Polytechnic, 297 Guangshan First Road, Tianhe District, Guangzhou, Guangdong 510520, China.
Ye WC; The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan City People's Hospital, Qingyuan, 511518, Guangdong, China. Electronic address: .
Zhao GJ; The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan City People's Hospital, Qingyuan, 511518, Guangdong, China. Electronic address: .
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Źródło :
International journal of cardiology [Int J Cardiol] 2021 Apr 01; Vol. 328, pp. 178. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Letter; Comment
MeSH Terms :
Doxycycline*/pharmacology
p38 Mitogen-Activated Protein Kinases*
Autophagy ; Humans ; Mitogen-Activated Protein Kinases ; Myocytes, Cardiac
Opinia redakcyjna
Tytuł :
The role of MKK4 in T-cell development and immunity to viral infections.
Autorzy :
Preston SP; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.
Doerflinger M; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.
Scott HW; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Allison CC; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.
Horton M; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.
Cooney J; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.
Pellegrini M; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.
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Źródło :
Immunology and cell biology [Immunol Cell Biol] 2021 Apr; Vol. 99 (4), pp. 428-435. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphocytic Choriomeningitis*
Mitogen-Activated Protein Kinases*/metabolism
Animals ; Cell Differentiation ; Enzyme Activation ; JNK Mitogen-Activated Protein Kinases/metabolism ; Mice ; Phosphorylation ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
miR‑351‑5p aggravates lipopolysaccharide‑induced acute lung injury via inhibiting AMPK.
Autorzy :
Hu F; Department of Pulmonary and Critical Care Medicine, The First People's Hospital of Jiangxia District, Wuhan, Hubei 430200, P.R. China.
Dong X; Department of Pulmonary and Critical Care Medicine, The First People's Hospital of Jiangxia District, Wuhan, Hubei 430200, P.R. China.
Li W; Department of Pulmonary and Critical Care Medicine, The First People's Hospital of Jiangxia District, Wuhan, Hubei 430200, P.R. China.
Lv J; Department of Thoracic Surgery, Hanchuan People's Hospital, Xiaogan, Hubei 431600, P.R. China.
Lin F; Department of Thoracic Surgery, Macheng People's Hospital, Huanggang, Hubei 438300, P.R. China.
Song G; Department of Thoracic Surgery, Macheng People's Hospital, Huanggang, Hubei 438300, P.R. China.
Hou G; Department of Thoracic Surgery, Yangxin People's Hospital, Huangshi, Hubei 435200, P.R. China.
Li R; Department of Pulmonary and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Oct; Vol. 24 (4). Date of Electronic Publication: 2021 Jul 30.
Typ publikacji :
Journal Article
MeSH Terms :
AMP-Activated Protein Kinases/*antagonists & inhibitors
Acute Lung Injury/*genetics
Acute Lung Injury/*metabolism
MicroRNAs/*genetics
MicroRNAs/*metabolism
Acute Lung Injury/chemically induced ; Animals ; Cyclic AMP/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Disease Models, Animal ; Inflammation/genetics ; Lipopolysaccharides/toxicity ; Male ; Mice, Inbred C57BL ; MicroRNAs/agonists ; MicroRNAs/antagonists & inhibitors ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Oxidative Stress/genetics
Czasopismo naukowe
Tytuł :
The immune regulatory effects of tetrahedral framework nucleic acid on human T cells via the mitogen-activated protein kinase pathway.
Autorzy :
Liu X; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Yu Z; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Wu Y; Sichuan Cancer Hospital & Institute, Centre for Translational Research in Cancer, Sichuan Cancer Center, Chengdu, China.
Shi S; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Yao J; Sichuan Cancer Hospital & Institute, Centre for Translational Research in Cancer, Sichuan Cancer Center, Chengdu, China.
Feng X; Sichuan Cancer Hospital & Institute, Centre for Translational Research in Cancer, Sichuan Cancer Center, Chengdu, China.
Wen D; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Shi Z; Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Zhao Z; Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Li Y; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Zhou H; Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
You C; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Lin Y; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; College of Biomedical Engineering, Sichuan University, Chengdu, China.
Yang M; Sichuan Cancer Hospital & Institute, Centre for Translational Research in Cancer, Sichuan Cancer Center, Chengdu, China.; School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
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Źródło :
Cell proliferation [Cell Prolif] 2021 Aug; Vol. 54 (8), pp. e13084. Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article
MeSH Terms :
MAP Kinase Signaling System/*drug effects
Mitogen-Activated Protein Kinases/*metabolism
Nucleic Acids/*pharmacology
Adult ; Cells, Cultured ; Cyclosporine/pharmacology ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Female ; Humans ; Interferon-gamma/metabolism ; JNK Mitogen-Activated Protein Kinases/metabolism ; Male ; Middle Aged ; Nanostructures/chemistry ; Neuromyelitis Optica/metabolism ; Neuromyelitis Optica/pathology ; Nucleic Acids/chemical synthesis ; Nucleic Acids/chemistry ; Phosphorylation/drug effects ; T-Lymphocytes/cytology ; T-Lymphocytes/drug effects ; T-Lymphocytes/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Cytokines Stimulated by IL-33 in Human Skin Mast Cells: Involvement of NF-κB and p38 at Distinct Levels and Potent Co-Operation with FcεRI and MRGPRX2.
Autorzy :
Franke K; Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Wang Z; Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.; Department of Dermatology, The Second Affiliated Hospital, Northwest Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
Zuberbier T; Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Babina M; Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 30; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 30.
Typ publikacji :
Journal Article
MeSH Terms :
Cytokines/*immunology
Interleukin-33/*pharmacology
Mast Cells/*drug effects
Nerve Tissue Proteins/*immunology
Receptors, G-Protein-Coupled/*immunology
Receptors, IgE/*immunology
Receptors, Neuropeptide/*immunology
Skin/*drug effects
p38 Mitogen-Activated Protein Kinases/*immunology
Foreskin/cytology ; Humans ; Interleukin-33/immunology ; JNK Mitogen-Activated Protein Kinases/metabolism ; Male ; Mast Cells/cytology ; Mast Cells/immunology ; Phosphorylation ; Primary Cell Culture ; Signal Transduction/drug effects ; Skin/immunology
Czasopismo naukowe
Tytuł :
SIKs (Salt-Inducible Kinases) in Arterial Restenosis.
Autorzy :
Shkedi O; The Department of Physiology, Biophysics and System Biology, The Rapport Institute and the Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa (O.S., I.K.).
Kehat I; The Department of Physiology, Biophysics and System Biology, The Rapport Institute and the Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa (O.S., I.K.).; Department of Cardiology and the Clinical Research Institute at Rambam, Rambam Medical Center, Haifa, Israel (I.K.).
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Sep; Vol. 41 (9), pp. 2452-2453. Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Editorial; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Protein Kinases*
Protein-Serine-Threonine Kinases*
Raport
Tytuł :
Compound essential oils relieve oxidative stress caused by PM 2 .5 exposure by inhibiting autophagy through the AMPK/mTOR pathway.
Autorzy :
Ren F; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning Province, China.
Xu X; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning Province, China.
Xu J; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning Province, China.
Mei Y; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning Province, China.
Zhang J; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning Province, China.
Wang X; Environmental Monitoring Station of Langfang, Langfang Environmental Protection Bureau, Langfang, Hebei Province, China.
Li F; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning Province, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Sep; Vol. 36 (9), pp. 1765-1774. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article
MeSH Terms :
AMP-Activated Protein Kinases*/genetics
AMP-Activated Protein Kinases*/metabolism
Oils, Volatile*
Autophagy ; Humans ; Oxidative Stress ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Enthalpy-Entropy Compensation in the Promiscuous Interaction of an Intrinsically Disordered Protein with Homologous Protein Partners.
Autorzy :
Kragelj J; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble, France.
Orand T; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble, France.
Delaforge E; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble, France.
Tengo L; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble, France.
Blackledge M; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble, France.
Palencia A; Institute for Advanced Biosciences, Structural Biology of Novel Targets in Human Diseases, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, Grenoble, France.
Jensen MR; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble, France.
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Źródło :
Biomolecules [Biomolecules] 2021 Aug 13; Vol. 11 (8). Date of Electronic Publication: 2021 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
JNK Mitogen-Activated Protein Kinases*/chemistry
JNK Mitogen-Activated Protein Kinases*/metabolism
MAP Kinase Kinase 4*/chemistry
MAP Kinase Kinase 4*/metabolism
Mitogen-Activated Protein Kinase 14*/chemistry
Mitogen-Activated Protein Kinase 14*/metabolism
Models, Molecular*
Humans ; Kinetics ; Protein Binding ; Protein Conformation ; Protein Folding
Czasopismo naukowe
Tytuł :
Molecular characterization of a novel p38 MAPK cDNA from Cyclina sinensis and its potential immune-related function under the threat of Vibrio anguillarum.
Autorzy :
Sun Z; College of Life Sciences, Tianjin Key Laboratory of Conservation and Utilization of Animal Diversity, Tianjin Normal University, Tianjin, China.
Sun W; College of Life Sciences, Tianjin Key Laboratory of Conservation and Utilization of Animal Diversity, Tianjin Normal University, Tianjin, China.
Pan B; College of Life Sciences, Tianjin Key Laboratory of Conservation and Utilization of Animal Diversity, Tianjin Normal University, Tianjin, China.
Yao Y; College of Life Sciences, Tianjin Key Laboratory of Conservation and Utilization of Animal Diversity, Tianjin Normal University, Tianjin, China.
Yan C; College of Life Sciences, Tianjin Key Laboratory of Conservation and Utilization of Animal Diversity, Tianjin Normal University, Tianjin, China. Electronic address: .
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Źródło :
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology [Comp Biochem Physiol B Biochem Mol Biol] 2021 Aug-Sep; Vol. 255, pp. 110599. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Journal Article
MeSH Terms :
Bivalvia*/genetics
Bivalvia*/immunology
Bivalvia*/microbiology
DNA, Complementary*/genetics
DNA, Complementary*/immunology
p38 Mitogen-Activated Protein Kinases*/genetics
p38 Mitogen-Activated Protein Kinases*/immunology
Vibrio/*immunology
Animals ; Cloning, Molecular
SCR Organism :
Vibrio anguillarum
Czasopismo naukowe
Tytuł :
C5aR deficiency attenuates the breast cancer development via the p38/p21 axis.
Autorzy :
Chen J; Department of Immunology, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Sun ZH; Breast Disease Center, Guiqian International General Hospital, Guiyang 550000, China.
Chen LY; Institute of Cancer, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China.
Xu F; Department of Immunology, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Zhao YP; Department of Immunology, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Li GQ; Department of Immunology, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Tang M; Urinary Nephropathy Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400065, China.
Li Y; Department of ICU, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Zheng QY; Department of Urology, 958 Hospital, Army Medical University (Third Military Medical University), Chongqing 400020, China.
Wang SF; Department of Immunology, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Yang XH; Breast Disease Center, Guiqian International General Hospital, Guiyang 550000, China.
Wu YZ; Department of Immunology, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Xu GL; Department of Immunology, Army Medical University (Third Military Medical University), Chongqing 400038, China.
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Źródło :
Aging [Aging (Albany NY)] 2020 Jul 15; Vol. 12 (14), pp. 14285-14299. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
p21-Activated Kinases*
p38 Mitogen-Activated Protein Kinases*
Breast Neoplasms/*genetics
Receptor, Anaphylatoxin C5a/*genetics
Signal Transduction/*genetics
Adult ; Animals ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cellular Senescence ; Complement C5a ; Female ; Humans ; MAP Kinase Signaling System ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Middle Aged ; Mitogen-Activated Protein Kinases/genetics ; Receptor, Anaphylatoxin C5a/antagonists & inhibitors ; Recombinant Proteins/pharmacology
Czasopismo naukowe
Tytuł :
The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo.
Autorzy :
Rackley B; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.; Cancer Biology Graduate Program, Emory University, Atlanta, GA, USA.
Seong CS; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.
Kiely E; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.; Winship Research Informatics, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Parker RE; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.; Cancer Biology Graduate Program, Emory University, Atlanta, GA, USA.
Rupji M; Biostatistics Shared Resource, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Dwivedi B; Bioinformatics and Systems Biology Shared Resource, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Heddleston JM; Advanced Imaging Center, Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Giang W; Integrated Cellular Imaging Core, Emory University School of Medicine, Emory University, Atlanta, GA, USA.
Anthony N; Integrated Cellular Imaging Core, Emory University School of Medicine, Emory University, Atlanta, GA, USA.
Chew TL; Advanced Imaging Center, Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Gilbert-Ross M; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA. .
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Źródło :
Communications biology [Commun Biol] 2021 Jan 29; Vol. 4 (1), pp. 142. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Genes, ras*
Mutation*
Drosophila Proteins/*genetics
Drosophila melanogaster/*genetics
Neoplasms, Experimental/*genetics
Protein Kinases/*genetics
AMP-Activated Protein Kinases/metabolism ; Adenocarcinoma of Lung/enzymology ; Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/mortality ; Animals ; Animals, Genetically Modified ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Cell Death ; Cell Movement ; Databases, Genetic ; Drosophila Proteins/metabolism ; Drosophila melanogaster/embryology ; Drosophila melanogaster/enzymology ; Enzyme Activation ; Genetic Predisposition to Disease ; Humans ; Larva/enzymology ; Larva/genetics ; Lung Neoplasms/enzymology ; Lung Neoplasms/genetics ; Lung Neoplasms/mortality ; Neoplasm Invasiveness ; Neoplasms, Experimental/enzymology ; Phenotype ; Protein Kinases/metabolism ; Protein-Serine-Threonine Kinases/genetics ; Proto-Oncogene Proteins p21(ras)/genetics
Czasopismo naukowe
Tytuł :
Potential for Protein Kinase Pharmacological Regulation in Flaviviridae Infections.
Autorzy :
Blázquez AB; Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), 28040 Madrid, Spain.
Saiz JC; Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), 28040 Madrid, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 15; Vol. 21 (24). Date of Electronic Publication: 2020 Dec 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Flaviviridae Infections/*drug therapy
Hepacivirus/*drug effects
Hepatitis C, Chronic/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Protein Kinases/*metabolism
Antiviral Agents/pharmacology ; Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Casein Kinase I/antagonists & inhibitors ; Casein Kinase I/metabolism ; Cyclin-Dependent Kinases/antagonists & inhibitors ; Cyclin-Dependent Kinases/metabolism ; Flaviviridae/drug effects ; Flaviviridae/enzymology ; Flaviviridae Infections/enzymology ; Hepacivirus/enzymology ; Hepacivirus/metabolism ; Hepatitis C, Chronic/metabolism ; Humans ; Phosphorylation ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Serine-Threonine Kinases/metabolism ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Alpha-lipoic acid attenuates silica-induced pulmonary fibrosis by improving mitochondrial function via AMPK/PGC1α pathway activation in C57BL/6J mice.
Autorzy :
Chang M; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Xu G; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Xiong C; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Yang X; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Yan S; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Tao Y; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Li H; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Li Y; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Yao S; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Zhao Y; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Oct 10; Vol. 350, pp. 121-132. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
AMP-Activated Protein Kinases/*metabolism
Mitochondria/*metabolism
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/*metabolism
Pulmonary Fibrosis/*chemically induced
Pulmonary Fibrosis/*drug therapy
Silicon Dioxide/*adverse effects
Silicosis/*drug therapy
Thioctic Acid/*therapeutic use
AMP-Activated Protein Kinases/drug effects ; Animals ; Antioxidants/metabolism ; Antioxidants/therapeutic use ; Humans ; Male ; Metabolic Networks and Pathways ; Mice ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Models, Animal ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/drug effects ; Pulmonary Fibrosis/metabolism ; Silicosis/metabolism ; Silicosis/physiopathology ; Thioctic Acid/metabolism
Czasopismo naukowe
Tytuł :
Sodium nitroprusside protects HFD induced gut dysfunction via activating AMPKα/SIRT1 signaling.
Autorzy :
Li X; Guangzhou Key Laboratory of Enhanced Recovery after Abdominal Surgery, Innovation Center for Advanced Interdisciplinary Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China.
Li C; Guangzhou Key Laboratory of Enhanced Recovery after Abdominal Surgery, Innovation Center for Advanced Interdisciplinary Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China.
Li Y; Guangzhou Key Laboratory of Enhanced Recovery after Abdominal Surgery, Innovation Center for Advanced Interdisciplinary Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China.
Liu C; Guangzhou Key Laboratory of Enhanced Recovery after Abdominal Surgery, Innovation Center for Advanced Interdisciplinary Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China.
Liang X; Guangzhou Key Laboratory of Enhanced Recovery after Abdominal Surgery, Innovation Center for Advanced Interdisciplinary Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China. .
Liu T; Guangzhou Key Laboratory of Enhanced Recovery after Abdominal Surgery, Innovation Center for Advanced Interdisciplinary Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China. .
Liu Z; Guangzhou Key Laboratory of Enhanced Recovery after Abdominal Surgery, Innovation Center for Advanced Interdisciplinary Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China. .
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Źródło :
BMC gastroenterology [BMC Gastroenterol] 2021 Oct 02; Vol. 21 (1), pp. 359. Date of Electronic Publication: 2021 Oct 02.
Typ publikacji :
Journal Article
MeSH Terms :
AMP-Activated Protein Kinases*/metabolism
Sirtuin 1*/genetics
Sirtuin 1*/metabolism
Animals ; Caco-2 Cells ; Diet, High-Fat ; Humans ; Mice ; Nitroprusside/pharmacology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Avicularin suppresses cartilage extracellular matrix degradation and inflammation via TRAF6/MAPK activation.
Autorzy :
Zou ZL; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Sun MH; Department of Joint Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210009, China.
Yin WF; Department of Orthopedics, Tonji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yang L; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: .
Kong LY; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Oct; Vol. 91, pp. 153657. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article
MeSH Terms :
Cartilage, Articular*
Mitogen-Activated Protein Kinases*/metabolism
TNF Receptor-Associated Factor 6*/metabolism
Extracellular Matrix/*drug effects
Flavonoids/*pharmacology
Animals ; Cartilage ; Cells, Cultured ; Disease Models, Animal ; Extracellular Matrix/pathology ; Humans ; Inflammation/drug therapy ; Rats
Czasopismo naukowe
Tytuł :
LINC00922 promotes the proliferation, migration, invasion and EMT process of liver cancer cells by regulating miR-424-5p/ARK5.
Autorzy :
Ye Z; Department of Hepatobiliary Surgery for Hernia, Ningbo First Hospital, No. 59 Liuting Street, Haishu District, Ningbo, 315000, Zhejiang Province, China. .
He Q; Department of Hepatobiliary Surgery for Hernia, Ningbo First Hospital, No. 59 Liuting Street, Haishu District, Ningbo, 315000, Zhejiang Province, China.
Wang Q; Department of Thyroid and Breast Surgery, Ningbo First Hospital, Haishu District, Ningbo, 315000, Zhejiang Province, China.
Lin Y; Department of Hepatobiliary Surgery for Hernia, Ningbo First Hospital, No. 59 Liuting Street, Haishu District, Ningbo, 315000, Zhejiang Province, China.
Cen K; Department of Hepatobiliary Surgery for Hernia, Ningbo First Hospital, No. 59 Liuting Street, Haishu District, Ningbo, 315000, Zhejiang Province, China.
Chen X; Department of Hepatobiliary Surgery for Hernia, Ningbo First Hospital, No. 59 Liuting Street, Haishu District, Ningbo, 315000, Zhejiang Province, China.
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Oct; Vol. 476 (10), pp. 3757-3769. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Movement*
Cell Proliferation*
Epithelial-Mesenchymal Transition*
Carcinoma, Hepatocellular/*metabolism
Liver Neoplasms/*metabolism
MicroRNAs/*metabolism
Neoplasm Proteins/*metabolism
Protein Kinases/*metabolism
RNA, Long Noncoding/*metabolism
RNA, Neoplasm/*metabolism
Repressor Proteins/*metabolism
Carcinoma, Hepatocellular/genetics ; Cell Line, Tumor ; Humans ; Liver Neoplasms/genetics ; MicroRNAs/genetics ; Neoplasm Invasiveness ; Neoplasm Proteins/genetics ; Protein Kinases/genetics ; RNA, Long Noncoding/genetics ; RNA, Neoplasm/genetics ; Repressor Proteins/genetics
Czasopismo naukowe
Tytuł :
Truncated variants of Ca -dependent protein kinases: a conserved regulatory mechanism?
Autorzy :
Loranger MEW; Department of Biology, Queen's University, Ontario, Canada.
Huffaker A; Department of Biological Sciences, University of California at San Diego, CA, USA.
Monaghan J; Department of Biology, Queen's University, Ontario, Canada. Electronic address: .
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Źródło :
Trends in plant science [Trends Plant Sci] 2021 Oct; Vol. 26 (10), pp. 1002-1005. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Arabidopsis*/enzymology
Arabidopsis*/genetics
Protein Kinases*/genetics
Czasopismo naukowe
Tytuł :
Genome-wide identification and analysis of Catharanthus roseus RLK1-like kinases in Nicotiana benthamiana.
Autorzy :
Rao S; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Biotechnology in Plant Protection of Ministry of Agriculture and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, 315211, China.
Wu X; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Biotechnology in Plant Protection of Ministry of Agriculture and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, 315211, China.; College of Life Science, China Jiliang University, Hangzhou, 310058, China.
Zheng H; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Biotechnology in Plant Protection of Ministry of Agriculture and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, 315211, China.
Lu Y; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Biotechnology in Plant Protection of Ministry of Agriculture and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, 315211, China.
Peng J; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Biotechnology in Plant Protection of Ministry of Agriculture and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, 315211, China.
Wu G; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Biotechnology in Plant Protection of Ministry of Agriculture and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, 315211, China.
Chen J; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Biotechnology in Plant Protection of Ministry of Agriculture and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, 315211, China.
Yan F; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Biotechnology in Plant Protection of Ministry of Agriculture and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, 315211, China. .
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Źródło :
BMC plant biology [BMC Plant Biol] 2021 Sep 18; Vol. 21 (1), pp. 425. Date of Electronic Publication: 2021 Sep 18.
Typ publikacji :
Journal Article
MeSH Terms :
Catharanthus/*genetics
Plant Proteins/*genetics
Protein Kinases/*genetics
Tobacco/*genetics
Catharanthus/enzymology ; Gene Expression Regulation, Plant ; Genome, Plant ; Host-Pathogen Interactions ; Phylogeny ; Plant Immunity/genetics ; Plant Leaves/genetics ; Plant Leaves/virology ; Plant Proteins/metabolism ; Promoter Regions, Genetic ; Protein Domains ; Protein Kinases/metabolism ; Pseudomonas syringae/pathogenicity ; Tobacco/microbiology ; Tobacco/virology ; Transcription Factors/genetics
Czasopismo naukowe

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