Temat: "Protein Multimerization" - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: Studying the mechanism of phase separation in aqueous solutions of globular proteins via molecular dynamics computer simulations.
Autorzy :: Brudar S; University of Ljubljana, Faculty of Chemistry and Chemical Technology, Večna pot 113, SI-1000 Ljubljana, Slovenia. .
Gujt J; University Duisburg-Essen, Faculty of Chemistry, Campus Essen, Universitätsstr. 5, D-45141 Essen, Germany and University of Paderborn, Dynamics of Condensed Matter and Center for Sustainable Systems Design, Chair of Theoretical Chemistry, Warburger Str. 100, D-33098 Paderborn, Germany.
Spohr E; University Duisburg-Essen, Faculty of Chemistry, Campus Essen, Universitätsstr. 5, D-45141 Essen, Germany.
Hribar-Lee B; University of Ljubljana, Faculty of Chemistry and Chemical Technology, Večna pot 113, SI-1000 Ljubljana, Slovenia. .; Pokaż więcej
Źródło :: Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2021 Jan 06; Vol. 23 (1), pp. 415-424.
Typ publikacji :: Journal Article
MeSH Terms :: Protein Multimerization*
Muramidase/*metabolism
gamma-Crystallins/*metabolism
Amino Acid Sequence ; Animals ; Arginine/chemistry ; Bacteriophage T4/chemistry ; Chickens ; Humans ; Lysine/chemistry ; Molecular Dynamics Simulation ; Muramidase/chemistry ; Protein Binding ; Temperature ; gamma-Crystallins/chemistry
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 2 2.

Tytuł :: Engineered trimeric ACE2 binds viral spike protein and locks it in "Three-up" conformation to potently inhibit SARS-CoV-2 infection.
Autorzy :: Guo L; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, 310024, China.; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310024, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310024, China.
Bi W; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, 310024, China.; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310024, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310024, China.
Wang X; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Fudan University, Shanghai, 200032, China.
Xu W; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Fudan University, Shanghai, 200032, China.
Yan R; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, 310024, China.; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310024, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310024, China.
Zhang Y; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, 310024, China.; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310024, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310024, China.
Zhao K; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, 310024, China.; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310024, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310024, China.
Li Y; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, 310024, China.; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310024, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310024, China.
Zhang M; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, 310024, China.; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310024, China.; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310024, China.
Cai X; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Fudan University, Shanghai, 200032, China.
Jiang S; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Fudan University, Shanghai, 200032, China.
Xie Y; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Fudan University, Shanghai, 200032, China.
Zhou Q; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, 310024, China. .; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310024, China. .; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310024, China. .
Lu L; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Fudan University, Shanghai, 200032, China. .
Dang B; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, 310024, China. .; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310024, China. .; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310024, China. .; Pokaż więcej
Źródło :: Cell research [Cell Res] 2021 Jan; Vol. 31 (1), pp. 98-100. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :: Letter; Research Support, Non-U.S. Gov't
MeSH Terms :: Mutation, Missense*
Protein Multimerization*
Angiotensin-Converting Enzyme 2/*chemistry
COVID-19/*drug therapy
SARS-CoV-2/*chemistry
Angiotensin-Converting Enzyme 2/pharmacology ; COVID-19/metabolism ; Humans ; Protein Binding ; Protein Engineering ; SARS-CoV-2/metabolism
: Raport

Szczegóły

Skocz do pozycji: 3 3.

Tytuł :: Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions.
Autorzy :: Carlson CR; Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Asfaha JB; Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Ghent CM; Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA.
Howard CJ; Department of Biochemistry & Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Hartooni N; Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Safari M; Department of Biochemistry & Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA.
Frankel AD; Department of Biochemistry & Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Morgan DO; Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: .; Pokaż więcej
Źródło :: Molecular cell [Mol Cell] 2020 Dec 17; Vol. 80 (6), pp. 1092-1103.e4. Date of Electronic Publication: 2020 Nov 20.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: COVID-19*
Protein Multimerization*
Coronavirus Nucleocapsid Proteins/*chemistry
RNA, Viral/*chemistry
SARS-CoV-2/*chemistry
Coronavirus Nucleocapsid Proteins/genetics ; Coronavirus Nucleocapsid Proteins/metabolism ; Humans ; Phosphoproteins/chemistry ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Phosphorylation ; Protein Domains ; RNA, Viral/genetics ; RNA, Viral/metabolism ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 4 4.

Tytuł :: Structurally plastic NEMO and oligomerization prone IKK2 subunits define the behavior of human IKK2:NEMO complexes in solution.
Autorzy :: Ko MS; Structural Biochemistry Laboratory, Department of Chemistry & Biochemistry, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182-1030, United States; Department of Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0357, United States.
Biswas T; Department of Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0357, United States.
Mulero MC; UC San Diego Moores Cancer Center, United States.
Bobkov AA; Sanford Burnham Prebys Medical Discovery Institute, United States.
Ghosh G; Department of Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0357, United States. Electronic address: .
Huxford T; Structural Biochemistry Laboratory, Department of Chemistry & Biochemistry, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182-1030, United States. Electronic address: .; Pokaż więcej
Źródło :: Biochimica et biophysica acta. Proteins and proteomics [Biochim Biophys Acta Proteins Proteom] 2020 Dec; Vol. 1868 (12), pp. 140526. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Protein Multimerization*
I-kappa B Kinase/*chemistry
Multiprotein Complexes/*chemistry
Humans ; Hydrodynamics ; I-kappa B Kinase/genetics ; I-kappa B Kinase/metabolism ; Multiprotein Complexes/metabolism ; Mutant Proteins ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Stability ; Recombinant Proteins ; Solutions ; Structure-Activity Relationship
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 5 5.

Tytuł :: Biased localization of actin binding proteins by actin filament conformation.
Autorzy :: Harris AR; Department of Bioengineering and Biophysics Program, University of California, Berkeley, 648 Stanley Hall MC 1762, Berkeley, CA, 94720, USA.
Jreij P; Department of Bioengineering and Biophysics Program, University of California, Berkeley, 648 Stanley Hall MC 1762, Berkeley, CA, 94720, USA.
Belardi B; Department of Bioengineering and Biophysics Program, University of California, Berkeley, 648 Stanley Hall MC 1762, Berkeley, CA, 94720, USA.
Joffe AM; Department of Bioengineering and Biophysics Program, University of California, Berkeley, 648 Stanley Hall MC 1762, Berkeley, CA, 94720, USA.
Bausch AR; Lehrstuhl für Biophysik (E27), Technische Universität München, Garching, 85748, Germany.
Fletcher DA; Department of Bioengineering and Biophysics Program, University of California, Berkeley, 648 Stanley Hall MC 1762, Berkeley, CA, 94720, USA. .; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, 648 Stanley Hall MC 1762, Berkeley, CA, 94720, USA. .; Chan Zuckerberg Biohub, San Francisco, CA, 94158, USA. .; Pokaż więcej
Źródło :: Nature communications [Nat Commun] 2020 Nov 25; Vol. 11 (1), pp. 5973. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Video-Audio Media
MeSH Terms :: Protein Multimerization*
Actin Cytoskeleton/*metabolism
Utrophin/*metabolism
Actin Cytoskeleton/chemistry ; Actin Depolymerizing Factors/metabolism ; Actins ; Animals ; Cytoplasm/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Intravital Microscopy ; Kinetics ; Microscopy, Fluorescence ; Mutation ; Neuropeptides/metabolism ; Point Mutation ; Protein Binding/genetics ; Protein Domains/genetics ; Rabbits ; Single Molecule Imaging ; Utrophin/chemistry ; Utrophin/genetics
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 6 6.

Tytuł :: Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break.
Autorzy :: Lou J; School of Physics, University of Melbourne, Melbourne, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Melbourne, Victoria, Australia.
Priest DG; School of Physics, University of Melbourne, Melbourne, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Melbourne, Victoria, Australia.
Solano A; School of Physics, University of Melbourne, Melbourne, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Melbourne, Victoria, Australia.
Kerjouan A; Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Melbourne, Victoria, Australia.
Hinde E; School of Physics, University of Melbourne, Melbourne, Victoria, Australia. .; Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Melbourne, Victoria, Australia. .; Pokaż więcej
Źródło :: Nature communications [Nat Commun] 2020 Nov 13; Vol. 11 (1), pp. 5776. Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: DNA Breaks, Double-Stranded*
Protein Multimerization*
Tumor Suppressor p53-Binding Protein 1/*metabolism
Cell Nucleus/metabolism ; DNA Repair ; Green Fluorescent Proteins/metabolism ; Histone Code ; Models, Biological ; Spectrometry, Fluorescence ; Time Factors
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 7 7.

Tytuł :: A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.
Autorzy :: van den Boomen DJH; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK. .
Sienkiewicz A; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK.
Berlin I; Leiden University Medical Centre, Leiden University, Leiden, The Netherlands.
Jongsma MLM; Leiden University Medical Centre, Leiden University, Leiden, The Netherlands.
van Elsland DM; Leiden University Medical Centre, Leiden University, Leiden, The Netherlands.
Luzio JP; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
Neefjes JJC; Leiden University Medical Centre, Leiden University, Leiden, The Netherlands.
Lehner PJ; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK. .; Pokaż więcej
Źródło :: Nature communications [Nat Commun] 2020 Nov 03; Vol. 11 (1), pp. 5559. Date of Electronic Publication: 2020 Nov 03.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Protein Multimerization*
Cholesterol/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Lysosomes/*metabolism
rab GTP-Binding Proteins/*metabolism
Biological Transport ; CRISPR-Cas Systems/genetics ; Cholesterol, LDL/metabolism ; Endosomes/metabolism ; Endosomes/ultrastructure ; Fluorescent Dyes/metabolism ; Genome, Human ; Guanine Nucleotide Exchange Factors/metabolism ; HEK293 Cells ; HeLa Cells ; Homeostasis ; Humans ; Hydroxymethylglutaryl-CoA Synthase/metabolism ; Lysosomes/ultrastructure ; Models, Biological ; Multiprotein Complexes/metabolism ; Protein Binding
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 8 8.

Tytuł :: Investigating ion transport inside the pentameric ion channel encoded in COVID-19 E protein.
Autorzy :: Saurabh K; Department of Engineering Science and Ocean Engineering, National Taiwan University, Taipei 10617, Taiwan.; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan 35053, Taiwan.; NTU High Performance and Scientific Computing Center, National Taiwan University, Taipei 10617, Taiwan.
Solovchuk M; Department of Engineering Science and Ocean Engineering, National Taiwan University, Taipei 10617, Taiwan.; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan 35053, Taiwan.
Sheu TW; Department of Engineering Science and Ocean Engineering, National Taiwan University, Taipei 10617, Taiwan.; Center for Advanced Study in Theoretical Sciences (CASTS), National Taiwan University, Taipei 10617, Taiwan.; NTU High Performance and Scientific Computing Center, National Taiwan University, Taipei 10617, Taiwan.; Pokaż więcej
Źródło :: Physical review. E [Phys Rev E] 2020 Nov; Vol. 102 (5-1), pp. 052408.
Typ publikacji :: Journal Article
MeSH Terms :: Models, Molecular*
Protein Multimerization*
Coronavirus Envelope Proteins/*chemistry
Coronavirus Envelope Proteins/*metabolism
Biological Transport ; Protein Structure, Quaternary
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 9 9.

Tytuł :: Dimeric states of transmembrane domains of insulin and IGF-1R receptors: Structures and possible role in activation.
Autorzy :: Kuznetsov AS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences RAS, str. Miklukho-Maklaya 16/10, Moscow 117997, Russian Federation; National Research University Higher School of Economics, Myasnitskaya ul. 20, Moscow 101000, Russian Federation; Moscow Institute of Physics and Technology, Institutsky per., 9, Dolgoprudnyi 141700, Russian Federation.
Zamaletdinov MF; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences RAS, str. Miklukho-Maklaya 16/10, Moscow 117997, Russian Federation; Lomonosov Moscow State University, Leninskiye Gory, 1, Moscow 119991, Russian Federation.
Bershatsky YV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences RAS, str. Miklukho-Maklaya 16/10, Moscow 117997, Russian Federation; Moscow Institute of Physics and Technology, Institutsky per., 9, Dolgoprudnyi 141700, Russian Federation.
Urban AS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences RAS, str. Miklukho-Maklaya 16/10, Moscow 117997, Russian Federation; Moscow Institute of Physics and Technology, Institutsky per., 9, Dolgoprudnyi 141700, Russian Federation.
Bocharova OV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences RAS, str. Miklukho-Maklaya 16/10, Moscow 117997, Russian Federation; Moscow Institute of Physics and Technology, Institutsky per., 9, Dolgoprudnyi 141700, Russian Federation.
Bennasroune A; UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne (URCA), UFR Sciences Exactes et Naturelles, Reims, France.
Maurice P; UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne (URCA), UFR Sciences Exactes et Naturelles, Reims, France.
Bocharov EV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences RAS, str. Miklukho-Maklaya 16/10, Moscow 117997, Russian Federation; Moscow Institute of Physics and Technology, Institutsky per., 9, Dolgoprudnyi 141700, Russian Federation.
Efremov RG; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences RAS, str. Miklukho-Maklaya 16/10, Moscow 117997, Russian Federation; National Research University Higher School of Economics, Myasnitskaya ul. 20, Moscow 101000, Russian Federation; Moscow Institute of Physics and Technology, Institutsky per., 9, Dolgoprudnyi 141700, Russian Federation. Electronic address: .; Pokaż więcej
Źródło :: Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2020 Nov 01; Vol. 1862 (11), pp. 183417. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Molecular Dynamics Simulation*
Protein Multimerization*
Receptor, IGF Type 1/*chemistry
Receptor, Insulin/*chemistry
Humans ; Nuclear Magnetic Resonance, Biomolecular ; Protein Domains
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 10 10.

Tytuł :: Tetramer protein complex interface residue pairs prediction with LSTM combined with graph representations.
Autorzy :: Sun D; Mathematics Intelligence Application LAB, Institute for Mathematical Sciences, Renmin University of China, Beijing 100872, PR China.
Gong X; Mathematics Intelligence Application LAB, Institute for Mathematical Sciences, Renmin University of China, Beijing 100872, PR China; Beijing Advanced Innovation Center for Structural Biology, Tsinghua Univeristy, Beijing 100091, PR China. Electronic address: .; Pokaż więcej
Źródło :: Biochimica et biophysica acta. Proteins and proteomics [Biochim Biophys Acta Proteins Proteom] 2020 Nov; Vol. 1868 (11), pp. 140504. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Protein Interaction Maps*
Protein Multimerization*
Amino Acids/chemistry ; Deep Learning ; Protein Conformation ; Proteins/chemistry ; Proteins/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 11 11.

Tytuł :: Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibrosis.
Autorzy :: Zheng D; Department of Abdominal Surgery, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Jiang Y; Department of Abdominal Surgery, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Qu C; Department of Abdominal Surgery, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Yuan H; Department of Abdominal Surgery, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Hu K; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
He L; Department of Abdominal Surgery, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Chen P; Department of Abdominal Surgery, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Li J; Department of Gastroenterology, the First Affiliated Hospital of Jinan University, Guangzhou, China.
Tu M; Department of Abdominal Surgery, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Lin L; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Chen H; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Lin Z; Department of Abdominal Surgery, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Lin W; Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Fan J; Departments of Medical Biochemistry and Molecular Biology, School of Medicine, Jinan University, Guangzhou, China.
Cheng G; Department of Pharmacy, College of Pharmacy, Jinan University, Guangzhou, China.
Hong J; Department of Abdominal Surgery, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China; Pathophysiology, School of Medicine, Jinan University, Guangzhou, China. Electronic address: .; Pokaż więcej
Źródło :: The American journal of pathology [Am J Pathol] 2020 Nov; Vol. 190 (11), pp. 2267-2281. Date of Electronic Publication: 2020 Aug 15.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Protein Multimerization*
Hepatic Stellate Cells/*enzymology
Liver Cirrhosis/*enzymology
Pyruvate Kinase/*metabolism
Acetylation ; Animals ; Cyclin D1/metabolism ; Female ; Hepatic Stellate Cells/pathology ; Histones/metabolism ; Humans ; Liver Cirrhosis/pathology ; Male ; Mice ; Organic Chemicals/pharmacology ; Proto-Oncogene Proteins c-myc/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 12 12.

Tytuł :: Crystal structure of tomato spotted wilt virus G N reveals a dimer complex formation and evolutionary link to animal-infecting viruses.
Autorzy :: Bahat Y; Azrieli Faculty of Medicine, Bar-Ilan University, Safed , Israel 1311502.
Alter J; Azrieli Faculty of Medicine, Bar-Ilan University, Safed , Israel 1311502.
Dessau M; Azrieli Faculty of Medicine, Bar-Ilan University, Safed , Israel 1311502 .; Pokaż więcej
Źródło :: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Oct 20; Vol. 117 (42), pp. 26237-26244. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Evolution, Molecular*
Protein Multimerization*
Glycoproteins/*chemistry
Insect Vectors/*virology
Lycopersicon esculentum/*virology
Tospovirus/*metabolism
Viral Proteins/*chemistry
Animals ; Crystallography, X-Ray ; Glycoproteins/metabolism ; Models, Molecular ; Protein Conformation ; Tospovirus/genetics ; Tospovirus/growth & development ; Viral Proteins/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 13 13.

Tytuł :: Conformation-dependent membrane permeabilization by neurotoxic PrP oligomers: The role of the H2H3 oligomerization domain.
Autorzy :: Huin C; Sorbonne Universités, CNRS, Institut Parisien de Chimie Moléculaire, Equipe Chimie des Polymères, 4 Place Jussieu, F-75005, Paris, France; University of Evry, F-91025, Evry, France.
Cronier S; UR892, Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique (INRA), Jouy-en-Josas, France.
Guégan P; Sorbonne Universités, CNRS, Institut Parisien de Chimie Moléculaire, Equipe Chimie des Polymères, 4 Place Jussieu, F-75005, Paris, France.
Béringue V; UR892, Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique (INRA), Jouy-en-Josas, France.
Rezaei H; UR892, Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique (INRA), Jouy-en-Josas, France.
Noinville S; UR892, Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique (INRA), Jouy-en-Josas, France; Sorbonne Universités, UPMC Univ Paris 06, CNRS, UMR8233, MONARIS, Université Pierre et Marie Curie, Paris, France. Electronic address: .; Pokaż więcej
Źródło :: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 Oct 15; Vol. 692, pp. 108517. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Cell Membrane Permeability*
Protein Multimerization*
Cell Membrane/*metabolism
Neurons/*metabolism
Pregnancy Proteins/*metabolism
Animals ; Cell Membrane/genetics ; Mice ; Mice, Knockout ; Pregnancy Proteins/genetics ; Protein Domains ; Protein Structure, Secondary
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 14 14.

Tytuł :: Separation of monoclonal antibody monomer-dimer mixtures by gradient elution with ceramic hydroxyapatite.
Autorzy :: Wang Y; Department of Chemical Engineering, University of Virginia, Charlottesville, VA, USA.
Carta G; Department of Chemical Engineering, University of Virginia, Charlottesville, VA, USA. Electronic address: .; Pokaż więcej
Źródło :: Journal of chromatography. A [J Chromatogr A] 2020 Oct 11; Vol. 1629, pp. 461465. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :: Journal Article
MeSH Terms :: Protein Multimerization*
Antibodies, Monoclonal/*isolation & purification
Ceramics/*chemistry
Durapatite/*chemistry
Adsorption ; Antibodies, Monoclonal/chemistry ; Computer Simulation ; Ions ; Kinetics ; Models, Chemical ; Polymers/chemistry ; Protein Binding ; Sodium/chemistry ; Temperature
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 15 15.

Tytuł :: Structural basis for dimerization quality control.
Autorzy :: Mena EL; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Jevtić P; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA, USA.
Greber BJ; California Institute for Quantitative Biosciences (QB3), University of California at Berkeley, Berkeley, CA, USA.; Molecular Biophysics and Integrative Bio-Imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Gee CL; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA, USA.
Lew BG; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA, USA.
Akopian D; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, USA.
Nogales E; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California at Berkeley, Berkeley, CA, USA.; Molecular Biophysics and Integrative Bio-Imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Kuriyan J; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California at Berkeley, Berkeley, CA, USA.; Molecular Biophysics and Integrative Bio-Imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; Department of Chemistry, University of California at Berkeley, Berkeley, CA, USA.
Rape M; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, USA. .; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA, USA. .; California Institute for Quantitative Biosciences (QB3), University of California at Berkeley, Berkeley, CA, USA. .; Pokaż więcej
Źródło :: Nature [Nature] 2020 Oct; Vol. 586 (7829), pp. 452-456. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :: BTB-POZ Domain*/genetics
Protein Multimerization*
F-Box Proteins/*metabolism
Stem Cell Factor/*metabolism
Humans ; Kelch-Like ECH-Associated Protein 1/chemistry ; Kelch-Like ECH-Associated Protein 1/genetics ; Kelch-Like ECH-Associated Protein 1/metabolism ; Models, Biological ; Models, Molecular ; Protein Binding ; Protein Folding ; Protein Stability ; Ubiquitination
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 16 16.

Tytuł :: The AHR1-ARNT1 dimerization pair is a major regulator of the response to natural ligands, but not to TCDD, in the chicken.
Autorzy :: Koh DH; Department of Life and Nanopharmaceutical Science, Kyung Hee University, Hoegi-Dong, Dongdaemun-Gu, Seoul, 130-701, South Korea.
Hwang JH; Department of Life and Nanopharmaceutical Science, Kyung Hee University, Hoegi-Dong, Dongdaemun-Gu, Seoul, 130-701, South Korea.
Park JG; Department of Life and Nanopharmaceutical Science, Kyung Hee University, Hoegi-Dong, Dongdaemun-Gu, Seoul, 130-701, South Korea.
Song WS; Department of Life and Nanopharmaceutical Science, Kyung Hee University, Hoegi-Dong, Dongdaemun-Gu, Seoul, 130-701, South Korea.
Iwata H; Center for Marine Environmental Studies (CMES), Ehime University, Matsuyama, 790-8577, Japan. Electronic address: .
Kim EY; Department of Life and Nanopharmaceutical Science, Kyung Hee University, Hoegi-Dong, Dongdaemun-Gu, Seoul, 130-701, South Korea; Department of Biology, Kyung Hee University, Hoegi-Dong, Dongdaemun-Gu, Seoul, 130-701, South Korea. Electronic address: .; Pokaż więcej
Źródło :: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Sep 15; Vol. 201, pp. 110835. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji :: Journal Article
MeSH Terms :: Protein Multimerization*
Aryl Hydrocarbon Receptor Nuclear Translocator/*metabolism
Chickens/*metabolism
Polychlorinated Dibenzodioxins/*metabolism
Receptors, Aryl Hydrocarbon/*metabolism
Xenobiotics/*metabolism
Animals ; Aryl Hydrocarbon Receptor Nuclear Translocator/genetics ; COS Cells ; Cell Line, Tumor ; Chlorocebus aethiops ; Computer Simulation ; Ligands ; Molecular Docking Simulation ; Protein Binding ; Protein Isoforms ; Receptors, Aryl Hydrocarbon/genetics ; Signal Transduction ; Species Specificity ; Transfection
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 17 17.

Tytuł :: Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains.
Autorzy :: Yu M; Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore.
Zhao Z; Department of Physics, National University of Singapore, Singapore, 117542, Singapore.
Chen Z; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.
Le S; Department of Physics, National University of Singapore, Singapore, 117542, Singapore. .
Yan J; Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore. .; Department of Physics, National University of Singapore, Singapore, 117542, Singapore. .; Pokaż więcej
Źródło :: Nature communications [Nat Commun] 2020 Sep 08; Vol. 11 (1), pp. 4476. Date of Electronic Publication: 2020 Sep 08.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Protein Engineering*
Protein Multimerization*
Protein Stability*
Actinin/chemistry ; Biomechanical Phenomena ; Connectin/chemistry ; Models, Molecular ; Molecular Dynamics Simulation ; Protein Conformation, alpha-Helical ; Protein Domains ; Protein Folding ; Protein Structure, Quaternary ; Protein Unfolding ; Single Molecule Imaging ; Temperature
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 18 18.

Tytuł :: Expression of cannabinoid CB 1 R-GPR55 heteromers in neuronal subtypes of the Macaca fascicularis striatum.
Autorzy :: Martínez-Pinilla E; Department of Morphology and Cell Biology, Faculty of Medicine, the University of Oviedo, Oviedo, Asturias, Spain.; Instituto de Neurociencias del Principado de Asturias (INEUROPA), Asturias, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Asturias, Spain.
Rico AJ; Neurosciences Division, Centre for Applied Medical Research (CIMA), the University of Navarra, Pamplona, Spain.; Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Rivas-Santisteban R; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Molecular Neurobiology Laboratory, Department of Biochemistry and Molecular Biomedicine, the University of Barcelona, Barcelona, Spain.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain.
Lillo J; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Molecular Neurobiology Laboratory, Department of Biochemistry and Molecular Biomedicine, the University of Barcelona, Barcelona, Spain.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain.
Roda E; Neurosciences Division, Centre for Applied Medical Research (CIMA), the University of Navarra, Pamplona, Spain.; Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Navarro G; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain.; Department of Biochemistry and Physiology, School of Pharmacy and Food Science, University of Barcelona, Barcelona, Spain.
Franco R; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Molecular Neurobiology Laboratory, Department of Biochemistry and Molecular Biomedicine, the University of Barcelona, Barcelona, Spain.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain.
Lanciego JL; Neurosciences Division, Centre for Applied Medical Research (CIMA), the University of Navarra, Pamplona, Spain.; Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Pokaż więcej
Źródło :: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2020 Sep; Vol. 1475 (1), pp. 34-42. Date of Electronic Publication: 2020 Jun 27.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Protein Multimerization*
Corpus Striatum/*metabolism
Neurons/*metabolism
Receptor, Cannabinoid, CB1/*metabolism
Receptors, Cannabinoid/*metabolism
Animals ; Antibodies/metabolism ; Biomarkers/metabolism ; Interneurons/metabolism ; Macaca fascicularis ; Male
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 19 19.

Tytuł :: Expression, purification and oligomerization of the S-adenosylmethionine transporter.
Autorzy :: Wang D; State Key Laboratory of Medicinal Chemical Biology, Tianjin, 300350, China; College of Pharmacy, Nankai University, Tianjin, 300350, China.
Liu M; State Key Laboratory of Medicinal Chemical Biology, Tianjin, 300350, China; College of Pharmacy, Nankai University, Tianjin, 300350, China.
Li X; State Key Laboratory of Medicinal Chemical Biology, Tianjin, 300350, China; College of Pharmacy, Nankai University, Tianjin, 300350, China.
Wang X; State Key Laboratory of Medicinal Chemical Biology, Tianjin, 300350, China; College of Pharmacy, Nankai University, Tianjin, 300350, China. Electronic address: .
Shen Y; State Key Laboratory of Medicinal Chemical Biology, Tianjin, 300350, China; College of Life Sciences, Nankai University, Tianjin, 300071, China. Electronic address: .; Pokaż więcej
Źródło :: Protein expression and purification [Protein Expr Purif] 2020 Sep; Vol. 173, pp. 105648. Date of Electronic Publication: 2020 Apr 23.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Amino Acid Transport Systems*/biosynthesis
Amino Acid Transport Systems*/chemistry
Amino Acid Transport Systems*/genetics
Amino Acid Transport Systems*/isolation & purification
Gene Expression*
Protein Multimerization*
Zebrafish Proteins*/biosynthesis
Zebrafish Proteins*/chemistry
Zebrafish Proteins*/genetics
Zebrafish Proteins*/isolation & purification
Zebrafish/*genetics
Animals ; Humans ; Male ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Zebrafish/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 20 20.

Tytuł :: Synthetic interleukin 22 (IL-22) signaling reveals biological activity of homodimeric IL-10 receptor 2 and functional cross-talk with the IL-6 receptor gp130.
Autorzy :: Mossner S; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Kuchner M; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Fazel Modares N; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Knebel B; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Al-Hasani H; Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Floss DM; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Scheller J; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany .; Pokaż więcej
Źródło :: The Journal of biological chemistry [J Biol Chem] 2020 Aug 28; Vol. 295 (35), pp. 12378-12397. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Protein Multimerization*
Cytokine Receptor gp130/*metabolism
Interleukin-10 Receptor beta Subunit/*metabolism
Interleukins/*metabolism
Animals ; CHO Cells ; Cricetulus ; Cytokine Receptor gp130/genetics ; HEK293 Cells ; Humans ; Interleukin-10 Receptor beta Subunit/genetics ; Interleukins/genetics ; Mice ; Protein Domains ; Receptors, Interleukin/genetics ; Receptors, Interleukin/metabolism
: Czasopismo naukowe

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