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Tytuł:
Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation.
Autorzy:
Cheng Q; Medical School of Nanjing University, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, 210093, China.
Wu J; Core Laboratory, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, China.
Xia Y; Medical School of Nanjing University, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, 210093, China.
Cheng Q; Department of Obstetrics, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, 210004, Jiangsu, China.
Zhao Y; Collaborative Innovation Center of Sustainable Forestry in Southern China, College of Forestry, Nanjing Forestry University, Nanjing, 210037, Jiangsu, China.
Zhu P; Medical School of Nanjing University, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, 210093, China.
Zhang W; Medical School of Nanjing University, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, 210093, China.
Zhang S; Department of General Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China.
Zhang L; Medical Imaging Center of Fuyang People's Hospital, Fuyang, Anhui Province, China.
Yuan Y; Medical Imaging Center of Fuyang People's Hospital, Fuyang, Anhui Province, China.
Li C; State Key Laboratory of Reproductive Medicine and China International Joint Research Center On Environment and Human Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. .
Chen G; Medical School of Nanjing University, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, 210093, China. .; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. .
Xue B; Core Laboratory, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, China. .; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, 211166, China. .
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Źródło:
Molecular brain [Mol Brain] 2023 Feb 13; Vol. 16 (1), pp. 24. Date of Electronic Publication: 2023 Feb 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Prenylation*
Neural Stem Cells*
Mice ; Animals ; Cerebellum ; Ataxia ; Cell Proliferation ; Mice, Knockout
SCR Disease Name:
Cerebellar Hypoplasia
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MALDI-MS Analysis of Peptide Libraries Expands the Scope of Substrates for Farnesyltransferase.
Autorzy:
Schey GL; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Buttery PH; Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Hildebrandt ER; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.
Novak SX; Department of Chemistry, Syracuse University, Syracuse, NY 13244, USA.
Schmidt WK; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.
Hougland JL; Department of Chemistry, Syracuse University, Syracuse, NY 13244, USA.; BioInspired Syracuse, Syracuse University, Syracuse, NY 13244, USA.
Distefano MD; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 07; Vol. 22 (21). Date of Electronic Publication: 2021 Nov 07.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Prenylation*
Farnesyltranstransferase/*metabolism
Proteome/*analysis
Amino Acid Sequence ; Animals ; Databases, Protein ; Humans ; Peptide Library ; Polyisoprenyl Phosphates/metabolism ; Protein Interaction Domains and Motifs ; Proteome/metabolism ; Proteomics/methods ; Rats ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae Proteins/metabolism ; Sesquiterpenes/metabolism ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Substrate Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A comprehensive in vivo screen of yeast farnesyltransferase activity reveals broad reactivity across a majority of CXXX sequences.
Autorzy:
Kim JH; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.
Hildebrandt ER; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.
Sarkar A; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.
Yeung W; Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.
Waldon RA; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.
Kannan N; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.; Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.
Schmidt WK; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.
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Źródło:
G3 (Bethesda, Md.) [G3 (Bethesda)] 2023 Jul 05; Vol. 13 (7).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Saccharomyces cerevisiae*/genetics
Saccharomyces cerevisiae*/metabolism
Alkyl and Aryl Transferases*/genetics
Alkyl and Aryl Transferases*/metabolism
Farnesyltranstransferase/genetics ; Farnesyltranstransferase/metabolism ; Amino Acid Sequence ; Protein Prenylation ; Proteins/genetics ; Substrate Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Metabolic labeling with an alkyne probe reveals similarities and differences in the prenylomes of several brain-derived cell lines and primary cells.
Autorzy:
Suazo KF; Department of Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA.
Jeong A; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA.
Ahmadi M; Department of Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA.
Brown C; Department of Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA.
Qu W; Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA.
Li L; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA.; Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA.
Distefano MD; Department of Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Feb 23; Vol. 11 (1), pp. 4367. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Protein Prenylation*
Brain/*metabolism
Proteome/*metabolism
Proteomics/*methods
Alkynes/chemistry ; Animals ; Astrocytes/metabolism ; Brain/cytology ; COS Cells ; Cells, Cultured ; Chlorocebus aethiops ; HeLa Cells ; Humans ; Mass Spectrometry/methods ; Mice ; Mice, Inbred C57BL ; Neurons/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prenyl Transferases Regulate Secretory Protein Sorting and Parasite Morphology in Toxoplasma gondii .
Autorzy:
Wang QQ; National Key Laboratory of Veterinary Public Health Security, School of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
He K; National Key Laboratory of Veterinary Public Health Security, School of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Aleem MT; Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, College of Sciences and Health Professions, Cleveland State University, Cleveland, OH 44115, USA.
Long S; National Key Laboratory of Veterinary Public Health Security, School of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Apr 12; Vol. 24 (8). Date of Electronic Publication: 2023 Apr 12.
Typ publikacji:
Journal Article
MeSH Terms:
Parasites*/metabolism
Toxoplasma*/metabolism
Animals ; Transferases/metabolism ; Farnesyltranstransferase/metabolism ; Protein Prenylation ; Protein Transport ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Novel KRAS Antibody Highlights a Regulation Mechanism of Post-Translational Modifications of KRAS during Tumorigenesis.
Autorzy:
Assi M; de Duve Institute, Université Catholique de Louvain, 1200 Brussels, Belgium.
Pirlot B; Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, 1200 Brussels, Belgium.
Stroobant V; Ludwig Institute for Cancer Research, Université Catholique de Louvain, 1200 Brussels, Belgium.
Thissen JP; Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, 1200 Brussels, Belgium.
Jacquemin P; de Duve Institute, Université Catholique de Louvain, 1200 Brussels, Belgium.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 02; Vol. 21 (17). Date of Electronic Publication: 2020 Sep 02.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Prenylation*
Protein Processing, Post-Translational*
Carcinogenesis/*pathology
Carcinoma, Pancreatic Ductal/*pathology
Pancreatic Neoplasms/*pathology
Proto-Oncogene Proteins p21(ras)/*immunology
Animals ; Antibody Formation ; Carcinogenesis/immunology ; Carcinogenesis/metabolism ; Carcinoma, Pancreatic Ductal/immunology ; Carcinoma, Pancreatic Ductal/metabolism ; HEK293 Cells ; Humans ; Mice ; Mice, Transgenic ; Pancreatic Neoplasms/immunology ; Pancreatic Neoplasms/metabolism ; Proto-Oncogene Proteins p21(ras)/metabolism ; Rabbits ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Mesenchymal subtype neuroblastomas are addicted to TGF-βR2/HMGCR-driven protein geranylgeranylation.
Autorzy:
Stokes ME; Department of Biological Sciences, Columbia University, New York City, NY, 10027, USA.
Small JC; Department of Biological Sciences, Columbia University, New York City, NY, 10027, USA.; Department of Medicine, Harvard Medical School, Chemical Biology and Therapeutic Sciences Program, Broad Institute, Boston, MA, 02115, USA.
Vasciaveo A; Department of Systems Biology, Columbia University, New York City, NY, 10027, USA.
Shimada K; Department of Biological Sciences, Columbia University, New York City, NY, 10027, USA.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.
Hirschhorn T; Department of Biological Sciences, Columbia University, New York City, NY, 10027, USA.
Califano A; Department of Systems Biology, Columbia University, New York City, NY, 10027, USA.
Stockwell BR; Department of Biological Sciences, Columbia University, New York City, NY, 10027, USA. .; Department of Chemistry, Columbia University, New York City, NY, 10027, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Jul 01; Vol. 10 (1), pp. 10748. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Prenylation*
Signal Transduction*
Neuroblastoma/*metabolism
Receptor, Transforming Growth Factor-beta Type II/*metabolism
Antineoplastic Agents/pharmacology ; Apoptosis ; Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; Fluvastatin/pharmacology ; Humans ; Hydroxymethylglutaryl CoA Reductases/metabolism ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Lipids/chemistry ; Lovastatin/pharmacology ; Methotrexate/pharmacology ; N-Myc Proto-Oncogene Protein/metabolism ; RNA, Small Interfering/metabolism ; Triamterene/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeting the Isoprenoid Biosynthetic Pathway in Multiple Myeloma.
Autorzy:
Haney SL; Department of Internal Medicine, University of Nebraska Medical Center, 986840 Nebraska Medical Center, Omaha, NE 68198, USA.
Holstein SA; Department of Internal Medicine, University of Nebraska Medical Center, 986840 Nebraska Medical Center, Omaha, NE 68198, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 21; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 21.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Multiple Myeloma*/pathology
Hydroxymethylglutaryl-CoA Reductase Inhibitors*/pharmacology
Humans ; Biosynthetic Pathways ; Diphosphonates/therapeutic use ; Diphosphonates/pharmacology ; Terpenes/metabolism ; Protein Prenylation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi.
Autorzy:
Souza ACO; a Department of Clinical Pharmacy and Translational Science , College of Pharmacy, University of Tennessee Health Science Center , Memphis , TN , USA.
Al Abdallah Q; a Department of Clinical Pharmacy and Translational Science , College of Pharmacy, University of Tennessee Health Science Center , Memphis , TN , USA.
DeJarnette K; a Department of Clinical Pharmacy and Translational Science , College of Pharmacy, University of Tennessee Health Science Center , Memphis , TN , USA.
Martin-Vicente A; a Department of Clinical Pharmacy and Translational Science , College of Pharmacy, University of Tennessee Health Science Center , Memphis , TN , USA.
Nywening AV; b Department of Molecular Immunology and Biochemistry , College of Graduate Health Sciences, University of Tennessee Health Science Center , Memphis , TN , USA.
DeJarnette C; b Department of Molecular Immunology and Biochemistry , College of Graduate Health Sciences, University of Tennessee Health Science Center , Memphis , TN , USA.
Sansevere EA; a Department of Clinical Pharmacy and Translational Science , College of Pharmacy, University of Tennessee Health Science Center , Memphis , TN , USA.
Ge W; a Department of Clinical Pharmacy and Translational Science , College of Pharmacy, University of Tennessee Health Science Center , Memphis , TN , USA.
Palmer GE; a Department of Clinical Pharmacy and Translational Science , College of Pharmacy, University of Tennessee Health Science Center , Memphis , TN , USA.
Fortwendel JR; a Department of Clinical Pharmacy and Translational Science , College of Pharmacy, University of Tennessee Health Science Center , Memphis , TN , USA.
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Źródło:
Virulence [Virulence] 2019 Dec; Vol. 10 (1), pp. 511-526.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Gene Expression Regulation, Fungal*
Protein Prenylation*
Aspergillus fumigatus/*pathogenicity
Fungal Proteins/*genetics
Animals ; Aspergillus fumigatus/genetics ; Candida albicans/genetics ; Candida albicans/pathogenicity ; Candidiasis/microbiology ; Farnesyltranstransferase/genetics ; Female ; Humans ; Hyphae/genetics ; Hyphae/growth & development ; Invasive Pulmonary Aspergillosis/microbiology ; Mice ; Mice, Inbred BALB C ; Virulence
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Protein Prenylation in Plant Stress Responses.
Autorzy:
Hála M; Department of Experimental Plant Biology, Faculty of Science, Charles University, Viničná 5, 128 44 Prague, Czech Republic. .
Žárský V; Department of Experimental Plant Biology, Faculty of Science, Charles University, Viničná 5, 128 44 Prague, Czech Republic. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2019 Oct 30; Vol. 24 (21). Date of Electronic Publication: 2019 Oct 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Protein Prenylation*
Stress, Physiological*
Plant Proteins/*metabolism
Plants/*metabolism
Biotechnology ; Substrate Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Impact of a conserved N-terminal proline-rich region of the α-subunit of CAAX-prenyltransferases on their enzyme properties.
Autorzy:
Hagemann A; Institute of Pharmacology and Toxicology, Centre of Biomedical Education and Science, School of Medicine, Faculty of Health, Witten/Herdecke University, Stockumer Strasse 10, 58453, Witten, Germany.
Tasillo S; Institute of Pharmacology and Toxicology, Centre of Biomedical Education and Science, School of Medicine, Faculty of Health, Witten/Herdecke University, Stockumer Strasse 10, 58453, Witten, Germany.
Aydin A; Institute of Pharmacology and Toxicology, Centre of Biomedical Education and Science, School of Medicine, Faculty of Health, Witten/Herdecke University, Stockumer Strasse 10, 58453, Witten, Germany.
Kehrenberg MCA; Institute of Pharmacology and Toxicology, Centre of Biomedical Education and Science, School of Medicine, Faculty of Health, Witten/Herdecke University, Stockumer Strasse 10, 58453, Witten, Germany.
Bachmann HS; Institute of Pharmacology and Toxicology, Centre of Biomedical Education and Science, School of Medicine, Faculty of Health, Witten/Herdecke University, Stockumer Strasse 10, 58453, Witten, Germany. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2022 Aug 08; Vol. 20 (1), pp. 118. Date of Electronic Publication: 2022 Aug 08.
Typ publikacji:
Journal Article; Video-Audio Media; Research Support, Non-U.S. Gov't
MeSH Terms:
Dimethylallyltranstransferase*
Animals ; Humans ; Mammals ; Proline ; Protein Prenylation ; Rats ; Saccharomyces cerevisiae ; Substrate Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.
Autorzy:
Jeong A; a Department of Experimental and Clinical Pharmacology , University of Minnesota , Minneapolis , MN , USA.
Suazo KF; b Department of Chemistry , University of Minnesota , Minneapolis , MN , USA.
Wood WG; c Department of Pharmacology , University of Minnesota , Minneapolis , MN , USA.
Distefano MD; b Department of Chemistry , University of Minnesota , Minneapolis , MN , USA.
Li L; a Department of Experimental and Clinical Pharmacology , University of Minnesota , Minneapolis , MN , USA.; c Department of Pharmacology , University of Minnesota , Minneapolis , MN , USA.
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Źródło:
Critical reviews in biochemistry and molecular biology [Crit Rev Biochem Mol Biol] 2018 Jun; Vol. 53 (3), pp. 279-310.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms:
Protein Prenylation*
Alzheimer Disease/*metabolism
Dimethylallyltranstransferase/*metabolism
Heterotrimeric GTP-Binding Proteins/*metabolism
Terpenes/*metabolism
Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Animals ; Dimethylallyltranstransferase/genetics ; Heterotrimeric GTP-Binding Proteins/genetics ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Functional classification and validation of yeast prenylation motifs using machine learning and genetic reporters.
Autorzy:
Berger BM; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America.
Yeung W; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America.; Institute of Bioinformatics, University of Georgia, Athens, Georgia, United States of America.
Goyal A; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America.
Zhou Z; Department of Computer Science, University of Georgia, Athens, Georgia, United States of America.
Hildebrandt ER; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America.
Kannan N; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America.; Institute of Bioinformatics, University of Georgia, Athens, Georgia, United States of America.
Schmidt WK; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America.
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Źródło:
PloS one [PLoS One] 2022 Jun 24; Vol. 17 (6), pp. e0270128. Date of Electronic Publication: 2022 Jun 24 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Alkyl and Aryl Transferases*/genetics
Saccharomyces cerevisiae*/genetics
Saccharomyces cerevisiae*/metabolism
Farnesyltranstransferase/genetics ; Farnesyltranstransferase/metabolism ; Machine Learning ; Protein Prenylation ; Substrate Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Protein Prenyltransferases and Their Inhibitors: Structural and Functional Characterization.
Autorzy:
Marchwicka A; Institute of Molecular and Industrial Biotechnology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 90-537 Lodz, Poland.
Kamińska D; Institute of Molecular and Industrial Biotechnology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 90-537 Lodz, Poland.
Monirialamdari M; Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, 90-924 Lodz, Poland.
Błażewska KM; Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, 90-924 Lodz, Poland.
Gendaszewska-Darmach E; Institute of Molecular and Industrial Biotechnology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 90-537 Lodz, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 May 12; Vol. 23 (10). Date of Electronic Publication: 2022 May 12.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Dimethylallyltranstransferase*/metabolism
Carbon/metabolism ; Farnesyltranstransferase ; Protein Prenylation ; Terpenes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Convenient synthetic approach for tri- and tetraprenylated cyclodipeptides by consecutive enzymatic prenylations.
Autorzy:
Wohlgemuth V; Institut für Pharmazeutische Biologie und Biotechnologie, Philipps-Universität Marburg, Robert-Koch-Straße 4, 35037, Marburg, Germany.
Kindinger F; Institut für Pharmazeutische Biologie und Biotechnologie, Philipps-Universität Marburg, Robert-Koch-Straße 4, 35037, Marburg, Germany.
Li SM; Institut für Pharmazeutische Biologie und Biotechnologie, Philipps-Universität Marburg, Robert-Koch-Straße 4, 35037, Marburg, Germany. .
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Źródło:
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2018 Mar; Vol. 102 (6), pp. 2671-2681. Date of Electronic Publication: 2018 Jan 25.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Prenylation*
Alkaloids/*metabolism
Aspergillus/*enzymology
Dimethylallyltranstransferase/*metabolism
Dimethylallyltranstransferase/chemistry ; Substrate Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Antioxidant Assessment of Prenylated Stilbenoid-Rich Extracts from Elicited Hairy Root Cultures of Three Cultivars of Peanut ( Arachis hypogaea ).
Autorzy:
Gajurel G; Arkansas Biosciences Institute, Arkansas State University, Jonesboro, AR 72467, USA.; Molecular Biosciences Graduate Program, Arkansas State University, Jonesboro, AR 72467, USA.
Hasan R; Arkansas Biosciences Institute, Arkansas State University, Jonesboro, AR 72467, USA.; Molecular Biosciences Graduate Program, Arkansas State University, Jonesboro, AR 72467, USA.
Medina-Bolivar F; Arkansas Biosciences Institute, Arkansas State University, Jonesboro, AR 72467, USA.; Department of Biological Sciences, Arkansas State University, Jonesboro, AR 72467, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Nov 10; Vol. 26 (22). Date of Electronic Publication: 2021 Nov 10.
Typ publikacji:
Journal Article
MeSH Terms:
Arachis/*metabolism
Oxidative Stress/*physiology
Stilbenes/*metabolism
Antioxidants/analysis ; Antioxidants/pharmacology ; Culture Media ; Eicosanoic Acids ; Fabaceae/metabolism ; Humans ; Plant Extracts/pharmacology ; Plant Roots/metabolism ; Protein Prenylation/physiology ; Stilbenes/chemistry ; Stilbenes/isolation & purification ; Stress, Physiological/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
Autorzy:
Jeong A; Department of Experimental and Clinical Pharmacology, University of Minnesota, 2001 6th Street SE, McGuire Translational Research Facility (MTRF) 4-208, Minneapolis, MN, 55455, USA.
Cheng S; Department of Experimental and Clinical Pharmacology, University of Minnesota, 2001 6th Street SE, McGuire Translational Research Facility (MTRF) 4-208, Minneapolis, MN, 55455, USA.; The Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, China.
Zhong R; Department of Experimental and Clinical Pharmacology, University of Minnesota, 2001 6th Street SE, McGuire Translational Research Facility (MTRF) 4-208, Minneapolis, MN, 55455, USA.
Bennett DA; Department of Neurological Sciences, Rush University, Chicago, IL, 60612, USA.; Rush Alzheimer's Disease Center, Rush University, Chicago, IL, 60612, USA.
Bergö MO; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
Li L; Department of Experimental and Clinical Pharmacology, University of Minnesota, 2001 6th Street SE, McGuire Translational Research Facility (MTRF) 4-208, Minneapolis, MN, 55455, USA. .; Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA. .; Graduate Program in Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2021 Jul 27; Vol. 9 (1), pp. 129. Date of Electronic Publication: 2021 Jul 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease/*genetics
Brain/*metabolism
Farnesyltranstransferase/*genetics
Neurons/*metabolism
Protein Prenylation/*genetics
Aged, 80 and over ; Alzheimer Disease/metabolism ; Amyloid beta-Protein Precursor/genetics ; Animals ; Behavior, Animal ; Cognitive Dysfunction/genetics ; Cognitive Dysfunction/metabolism ; Disease Models, Animal ; Extracellular Signal-Regulated MAP Kinases ; Farnesyltranstransferase/metabolism ; Female ; Humans ; Male ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mice ; Mice, Knockout ; Mice, Transgenic ; Plaque, Amyloid/genetics ; Plaque, Amyloid/metabolism ; Presenilin-1/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A prenylated dsRNA sensor protects against severe COVID-19.
Autorzy:
Wickenhagen A; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Sugrue E; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Lytras S; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Kuchi S; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Noerenberg M; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Turnbull ML; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Loney C; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Herder V; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Allan J; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Jarmson I; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Cameron-Ruiz N; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Varjak M; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Pinto RM; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Lee JY; Department of Biochemistry, University of Oxford, Oxford, UK.
Iselin L; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.; Department of Biochemistry, University of Oxford, Oxford, UK.; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Palmalux N; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Stewart DG; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Swingler S; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Greenwood EJD; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.
Crozier TWM; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.
Gu Q; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Davies EL; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Clohisey S; Roslin Institute, University of Edinburgh, Edinburgh, UK.
Wang B; Roslin Institute, University of Edinburgh, Edinburgh, UK.
Trindade Maranhão Costa F; Laboratory of Tropical Diseases, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Sao Paolo, Brazil.
Freire Santana M; Department of Education and Research, Oncology Control Centre of Amazonas State (FCECON), Manaus, Amazonas, Brazil.
de Lima Ferreira LC; Postgraduate Program in Tropical Medicine, Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
Murphy L; Edinburgh Clinical Research Facility, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Fawkes A; Edinburgh Clinical Research Facility, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Meynert A; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Grimes G; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Da Silva Filho JL; Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Marti M; Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Hughes J; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Stanton RJ; Division of Infection & Immunity, Cardiff University, Cardiff, UK.
Wang ECY; Division of Infection & Immunity, Cardiff University, Cardiff, UK.
Ho A; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Davis I; Department of Biochemistry, University of Oxford, Oxford, UK.
Jarrett RF; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Castello A; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Robertson DL; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Semple MG; NIHR Health Protection Research Unit for Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; Respiratory Medicine, Alder Hey Children's Hospital, Liverpool, UK.
Openshaw PJM; National Heart and Lung Institute, Imperial College London, London, UK.; Imperial College Healthcare, National Health Service Trust London, London, UK.
Palmarini M; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Lehner PJ; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.
Baillie JK; Roslin Institute, University of Edinburgh, Edinburgh, UK.; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.
Rihn SJ; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
Wilson SJ; Medical Research Council-University of Glasgow Centre for Virus Research (CVR), Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK.
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Corporate Authors:
ISARIC4C Investigators
Źródło:
Science (New York, N.Y.) [Science] 2021 Oct 29; Vol. 374 (6567), pp. eabj3624. Date of Electronic Publication: 2021 Oct 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
2',5'-Oligoadenylate Synthetase/*genetics
2',5'-Oligoadenylate Synthetase/*metabolism
COVID-19/*genetics
COVID-19/*physiopathology
RNA, Double-Stranded/*metabolism
RNA, Viral/*metabolism
SARS-CoV-2/*physiology
5' Untranslated Regions ; A549 Cells ; Animals ; COVID-19/enzymology ; COVID-19/immunology ; Chiroptera/genetics ; Chiroptera/virology ; Coronaviridae/enzymology ; Coronaviridae/genetics ; Coronaviridae/physiology ; Endoribonucleases/metabolism ; Humans ; Interferons/immunology ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Phosphoric Diester Hydrolases/genetics ; Phosphoric Diester Hydrolases/metabolism ; Polymorphism, Single Nucleotide ; Protein Prenylation ; RNA, Double-Stranded/chemistry ; RNA, Double-Stranded/genetics ; RNA, Viral/chemistry ; RNA, Viral/genetics ; Retroelements ; SARS-CoV-2/genetics ; Severity of Illness Index ; Virus Replication
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Macrothrombocytopenia of Takenouchi-Kosaki syndrome is ameliorated by CDC42 specific- and lipidation inhibitors in MEG-01 cells.
Autorzy:
Daimon E; Department of Molecular Medicine, Research Institute, Osaka Women's and Children's Hospital, 840 Murodo-cho, Izumi, Osaka, 594-1101, Japan.
Shibukawa Y; Department of Molecular Medicine, Research Institute, Osaka Women's and Children's Hospital, 840 Murodo-cho, Izumi, Osaka, 594-1101, Japan.
Thanasegaran S; Department of Molecular Medicine, Research Institute, Osaka Women's and Children's Hospital, 840 Murodo-cho, Izumi, Osaka, 594-1101, Japan.
Yamazaki N; Department of Molecular Medicine, Research Institute, Osaka Women's and Children's Hospital, 840 Murodo-cho, Izumi, Osaka, 594-1101, Japan.
Okamoto N; Department of Molecular Medicine, Research Institute, Osaka Women's and Children's Hospital, 840 Murodo-cho, Izumi, Osaka, 594-1101, Japan. .; Department of Medical Genetics, Research Institute, Osaka Women's and Children's Hospital, 840 Murodo-cho, Izumi, Osaka, 594-1101, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2021 Sep 09; Vol. 11 (1), pp. 17990. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Megakaryocytes/*drug effects
Megakaryocytes/*metabolism
Signal Transduction/*drug effects
Thrombocytopenia/*metabolism
cdc42 GTP-Binding Protein/*antagonists & inhibitors
cdc42 GTP-Binding Protein/*metabolism
Actins/metabolism ; Alkyl and Aryl Transferases/antagonists & inhibitors ; Benzamides/pharmacology ; Blood Platelets/metabolism ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Membrane/metabolism ; HEK293 Cells ; Humans ; Mutation ; Protein Prenylation/drug effects ; Pyrazoles/pharmacology ; Signal Transduction/genetics ; Sulfonamides/pharmacology ; Syndrome ; Thrombocytopenia/genetics ; Thrombopoiesis/drug effects ; Thrombopoiesis/genetics ; Transfection ; Wiskott-Aldrich Syndrome Protein, Neuronal/metabolism ; cdc42 GTP-Binding Protein/genetics ; p21-Activated Kinases/metabolism ; rho Guanine Nucleotide Dissociation Inhibitor alpha/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Double prenylation of SNARE protein Ykt6 is required for lysosomal hydrolase trafficking.
Autorzy:
Sakata N; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
Shirakawa R; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
Goto K; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
Trinh DA; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
Horiuchi H; Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
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Źródło:
Journal of biochemistry [J Biochem] 2021 Apr 18; Vol. 169 (3), pp. 363-370.
Typ publikacji:
Journal Article
MeSH Terms:
Hydrolases/*metabolism
Lysosomes/*metabolism
R-SNARE Proteins/*metabolism
SNARE Proteins/*metabolism
Alkyl and Aryl Transferases/metabolism ; Animals ; Dimethylallyltranstransferase/metabolism ; Golgi Apparatus/metabolism ; HeLa Cells ; Humans ; Membrane Fusion ; Protein Prenylation ; Protein Transport
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 649

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