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Wyszukujesz frazę ""Protein Stability"" wg kryterium: Temat


Tytuł :
All atom insights into the impact of crowded environments on protein stability by NMR spectroscopy.
Autorzy :
Köhn B; Department of Chemistry, University of Konstanz, Universitätsstrasse. 10, 78457, Konstanz, Germany.; Konstanz Research School Chemical Biology KoRS-CB, University of Konstanz, Universitätsstrasse. 10, 78457, Konstanz, Germany.
Kovermann M; Department of Chemistry, University of Konstanz, Universitätsstrasse. 10, 78457, Konstanz, Germany. .; Konstanz Research School Chemical Biology KoRS-CB, University of Konstanz, Universitätsstrasse. 10, 78457, Konstanz, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 13; Vol. 11 (1), pp. 5760. Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Magnetic Resonance Spectroscopy*
Protein Stability*
Macromolecular Substances/*chemistry
Bacillus subtilis/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Hydrodynamics ; Models, Molecular ; Protein Folding ; Thermodynamics ; Urea/pharmacology
Czasopismo naukowe
Tytuł :
Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains.
Autorzy :
Yu M; Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore.
Zhao Z; Department of Physics, National University of Singapore, Singapore, 117542, Singapore.
Chen Z; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.
Le S; Department of Physics, National University of Singapore, Singapore, 117542, Singapore. .
Yan J; Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore. .; Department of Physics, National University of Singapore, Singapore, 117542, Singapore. .
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Źródło :
Nature communications [Nat Commun] 2020 Sep 08; Vol. 11 (1), pp. 4476. Date of Electronic Publication: 2020 Sep 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Engineering*
Protein Multimerization*
Protein Stability*
Actinin/chemistry ; Biomechanical Phenomena ; Connectin/chemistry ; Models, Molecular ; Molecular Dynamics Simulation ; Protein Conformation, alpha-Helical ; Protein Domains ; Protein Folding ; Protein Structure, Quaternary ; Protein Unfolding ; Single Molecule Imaging ; Temperature
Czasopismo naukowe
Tytuł :
A method for efficient calculation of thermal stability of proteins upon point mutations.
Autorzy :
Wang B; Shanghai Engineering Research Center of Molecular Therapeutics & New Drug Development, Shanghai Key Laboratory of Green Chemistry & Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
Qi Y; Shanghai Engineering Research Center of Molecular Therapeutics & New Drug Development, Shanghai Key Laboratory of Green Chemistry & Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China and NYU-ECNU Center for Computational Chemistry at NYU Shanghai, Shanghai 200062, China. .
Gao Y; Shanghai Engineering Research Center of Molecular Therapeutics & New Drug Development, Shanghai Key Laboratory of Green Chemistry & Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China and School of Mathematics, Physics and Statistics, Shanghai University of Engineering Science, Shanghai 201620, China.
Zhang JZH; Shanghai Engineering Research Center of Molecular Therapeutics & New Drug Development, Shanghai Key Laboratory of Green Chemistry & Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China and NYU-ECNU Center for Computational Chemistry at NYU Shanghai, Shanghai 200062, China. and Department of Chemistry, New York University, NY, NY 10003, USA and Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan, Shanxi 030006, China.
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Źródło :
Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2020 Apr 29; Vol. 22 (16), pp. 8461-8466.
Typ publikacji :
Journal Article
MeSH Terms :
Computational Chemistry*
Point Mutation*
Protein Stability*
Chemistry Techniques, Analytical/*methods
Proteins/*genetics
Temperature
Czasopismo naukowe
Tytuł :
A Conserved Helix in the C-Terminal Region of Watermelon Silver Mottle Virus Nonstructural Protein S Is Imperative For Protein Stability Affecting Self-Interaction, RNA Silencing Suppression, and Pathogenicity.
Autorzy :
Huang CH; Department of Plant Pathology, National Chung Hsing University, Taichung 40227, Taiwan, Republic of China.; Advanced Plant Biotechnology Center, National Chung Hsing University.
Foo MH; Department of Plant Pathology, National Chung Hsing University, Taichung 40227, Taiwan, Republic of China.
Raja JAJ; Department of Plant Pathology, National Chung Hsing University, Taichung 40227, Taiwan, Republic of China.; Advanced Plant Biotechnology Center, National Chung Hsing University.
Tan YR; Department of Plant Pathology, National Chung Hsing University, Taichung 40227, Taiwan, Republic of China.
Lin TT; Department of Plant Pathology, National Chung Hsing University, Taichung 40227, Taiwan, Republic of China.
Lin SS; Advanced Plant Biotechnology Center, National Chung Hsing University.; Institute of Biotechnology, National Taiwan University, Taipei 106, Taiwan, Republic of China.
Yeh SD; Department of Plant Pathology, National Chung Hsing University, Taichung 40227, Taiwan, Republic of China.; Advanced Plant Biotechnology Center, National Chung Hsing University.
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Źródło :
Molecular plant-microbe interactions : MPMI [Mol Plant Microbe Interact] 2020 Apr; Vol. 33 (4), pp. 637-652. Date of Electronic Publication: 2020 Feb 26.
Typ publikacji :
Journal Article
MeSH Terms :
Protein S*/chemistry
Protein S*/genetics
Protein Stability*
Tospovirus*/chemistry
Tospovirus*/genetics
Viral Nonstructural Proteins*
RNA Interference ; Tobacco/virology ; Virulence/genetics
SCR Organism :
Watermelon silver mottle tospovirus
Czasopismo naukowe
Tytuł :
Protein stability governed by its structural plasticity is inferred by physicochemical factors and salt bridges.
Autorzy :
Panja AS; Post Graduate Department of Biotechnology, Molecular informatics Laboratory, Oriental Institute of Science and Technology, Vidyasagar University, Midnapore, West Bengal, India. .
Maiti S; Post Graduate Department of Biochemistry and Biotechnology, Cell and Molecular Therapeutics Laboratory, Oriental Institute of Science and Technology, Vidyasagar University, Midnapore, West Bengal, India.
Bandyopadhyay B; Post Graduate Department of Biotechnology, Molecular informatics Laboratory, Oriental Institute of Science and Technology, Vidyasagar University, Midnapore, West Bengal, India.
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Źródło :
Scientific reports [Sci Rep] 2020 Feb 04; Vol. 10 (1), pp. 1822. Date of Electronic Publication: 2020 Feb 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Stability*
Amino Acid Sequence ; Amino Acids/metabolism ; Computer Simulation ; Extremophiles/metabolism ; Hydrophobic and Hydrophilic Interactions ; Isoelectric Point ; Protein Conformation ; Sequence Alignment
Czasopismo naukowe
Tytuł :
Dynamic conformational flexibility and molecular interactions of intrinsically disordered proteins.
Autorzy :
Bhattarai A; Bioinformatics Programming Laboratory, Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore 632 014, India.
Emerson IA
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Źródło :
Journal of biosciences [J Biosci] 2020; Vol. 45.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Protein Conformation*
Protein Stability*
Intrinsically Disordered Proteins/*chemistry
Intrinsically Disordered Proteins/*metabolism
Drug Delivery Systems ; Protein Binding ; Protein Domains ; Protein Folding
Czasopismo naukowe
Tytuł :
Robust Prediction of Single and Multiple Point Protein Mutations Stability Changes.
Autorzy :
Álvarez-Machancoses Ó; Group of Inverse Problems, Optimization and Machine Learning, Department of Mathematics, University of Oviedo, C. Federico García Lorca, 18, 33007 Oviedo, Spain.
De Andrés-Galiana EJ; Group of Inverse Problems, Optimization and Machine Learning, Department of Mathematics, University of Oviedo, C. Federico García Lorca, 18, 33007 Oviedo, Spain.; Department of Computer Science, University of Oviedo, C. Federico García Lorca, 18, 33007 Oviedo, Spain.
Fernández-Martínez JL; Group of Inverse Problems, Optimization and Machine Learning, Department of Mathematics, University of Oviedo, C. Federico García Lorca, 18, 33007 Oviedo, Spain.
Kloczkowski A; Battelle Center for Mathematical Medicine, Nationwide Children's Hospital, Columbus, OH 43205, USA.; Department of Pediatrics, The Ohio State University, Columbus, OH 43210, USA.
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Źródło :
Biomolecules [Biomolecules] 2019 Dec 31; Vol. 10 (1). Date of Electronic Publication: 2019 Dec 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Neural Networks, Computer*
Protein Stability*
Proteins/*genetics
Amino Acids/chemistry ; Amino Acids/genetics ; Databases, Protein ; Machine Learning ; Point Mutation/genetics ; Proteins/chemistry ; Thermodynamics
Czasopismo naukowe
Tytuł :
Structural cavities are critical to balancing stability and activity of a membrane-integral enzyme.
Autorzy :
Guo R; Department of Chemistry, Michigan State University, East Lansing, MI 48824.
Cang Z; Department of Mathematics, Michigan State University, East Lansing, MI 48824.
Yao J; Department of Chemistry, Michigan State University, East Lansing, MI 48824.
Kim M; Department of Chemistry, Michigan State University, East Lansing, MI 48824.
Deans E; Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI 48824.
Wei G; Department of Mathematics, Michigan State University, East Lansing, MI 48824.
Kang SG; Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, NY 10598 .
Hong H; Department of Chemistry, Michigan State University, East Lansing, MI 48824; .; Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI 48824.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 08; Vol. 117 (36), pp. 22146-22156. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA-Binding Proteins/*chemistry
Endopeptidases/*chemistry
Escherichia coli Proteins/*chemistry
Membrane Proteins/*chemistry
Catalytic Domain ; DNA-Binding Proteins/metabolism ; Endopeptidases/metabolism ; Escherichia coli Proteins/metabolism ; Humans ; Membrane Proteins/metabolism ; Models, Molecular ; Molecular Dynamics Simulation ; Mutation ; Protein Conformation ; Protein Folding ; Protein Stability ; Serine Endopeptidases/chemistry
Czasopismo naukowe
Tytuł :
Structure and functional properties of soy protein isolate-lentinan conjugates obtained in Maillard reaction by slit divergent ultrasonic assisted wet heating and the stability of oil-in-water emulsions.
Autorzy :
Wen C; School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address: .
Zhang J; School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address: .
Qin W; School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.
Gu J; School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.
Zhang H; School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address: .
Duan Y; School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China; Institute of Food Physical Processing, Jiangsu University, Zhenjiang 212013, China. Electronic address: .
Ma H; School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China; Institute of Food Physical Processing, Jiangsu University, Zhenjiang 212013, China.
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Źródło :
Food chemistry [Food Chem] 2020 Nov 30; Vol. 331, pp. 127374. Date of Electronic Publication: 2020 Jun 21.
Typ publikacji :
Journal Article
MeSH Terms :
Maillard Reaction*
Emulsions/*chemistry
Lentinan/*chemistry
Soybean Proteins/*chemistry
Circular Dichroism ; Emulsifying Agents/chemistry ; Fluorescence ; Food-Processing Industry/methods ; Glycosylation ; Heating ; Hydrophobic and Hydrophilic Interactions ; Protein Stability ; Protein Structure, Secondary ; Solubility ; Soybean Proteins/isolation & purification ; Ultrasonics ; Viscosity ; Water/chemistry
Czasopismo naukowe
Tytuł :
Design of an engineered ACE2 as a novel therapeutics against COVID-19.
Autorzy :
Payandeh Z; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Rahbar MR; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Jahangiri A; Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Hashemi ZS; ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
Zakeri A; Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran.
Jafarisani M; Clinical Biochemistry, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Rasaee MJ; Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Khalili S; Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran. Electronic address: .
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Źródło :
Journal of theoretical biology [J Theor Biol] 2020 Nov 21; Vol. 505, pp. 110425. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Betacoronavirus/*metabolism
Coronavirus Infections/*drug therapy
Peptidyl-Dipeptidase A/*genetics
Peptidyl-Dipeptidase A/*metabolism
Pneumonia, Viral/*drug therapy
Protein Engineering/*methods
Amino Acid Substitution ; Betacoronavirus/genetics ; Binding Sites ; Directed Molecular Evolution ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/therapeutic use ; Protein Binding ; Protein Interaction Domains and Motifs/genetics ; Protein Stability ; Spike Glycoprotein, Coronavirus/metabolism
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Static all-atom energetic mappings of the SARS-Cov-2 spike protein and dynamic stability analysis of "Up" versus "Down" protomer states.
Autorzy :
Peters MH; Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Bastidas O; College of Biological Sciences, University of Minnesota, Minneapolis, Minnesota, United States of America.
Kokron DS; NASA Ames Research Center, Moffett Field, California, United Sates of America.
Henze CE; NASA Ames Research Center, Moffett Field, California, United Sates of America.
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Źródło :
PloS one [PLoS One] 2020 Nov 10; Vol. 15 (11), pp. e0241168. Date of Electronic Publication: 2020 Nov 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Betacoronavirus/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Betacoronavirus/isolation & purification ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Humans ; Molecular Dynamics Simulation ; Pandemics ; Peptidyl-Dipeptidase A/chemistry ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Point Mutation ; Protein Binding ; Protein Domains ; Protein Stability ; Protein Subunits/chemistry ; Protein Subunits/genetics ; Protein Subunits/metabolism ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Thermodynamics
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Parallel evolution in the emergence of highly pathogenic avian influenza A viruses.
Autorzy :
Escalera-Zamudio M; Department of Zoology, Oxford University, Parks Rd, Oxford, OX1 3PS, UK. .
Golden M; Department of Zoology, Oxford University, Parks Rd, Oxford, OX1 3PS, UK.
Gutiérrez B; Department of Zoology, Oxford University, Parks Rd, Oxford, OX1 3PS, UK.
Thézé J; Department of Zoology, Oxford University, Parks Rd, Oxford, OX1 3PS, UK.
Keown JR; Division of Structural Biology, Wellcome Centre for Human Genetics, Oxford, OX3 7BN, UK.
Carrique L; Division of Structural Biology, Wellcome Centre for Human Genetics, Oxford, OX3 7BN, UK.
Bowden TA; Division of Structural Biology, Wellcome Centre for Human Genetics, Oxford, OX3 7BN, UK.
Pybus OG; Department of Zoology, Oxford University, Parks Rd, Oxford, OX1 3PS, UK. .; Department of Pathobiology and Population Sciences, Royal Veterinary College, London, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 02; Vol. 11 (1), pp. 5511. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Evolution, Molecular*
Influenza A virus/*pathogenicity
Influenza in Birds/*virology
Influenza, Human/*virology
Virulence/*genetics
Animals ; Base Sequence/genetics ; Birds/virology ; Datasets as Topic ; Genome, Viral/genetics ; Humans ; Influenza A virus/genetics ; Influenza in Birds/transmission ; Influenza, Human/transmission ; Mutation ; Phylogeny ; Protein Stability ; Selection, Genetic ; Sequence Alignment ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer.
Autorzy :
Shi Q; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
Li Y; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
Li S; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
Jin L; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
Lai H; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
Wu Y; Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, 510080, Guangzhou, China.
Cai Z; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
Zhu M; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
Li Q; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
Li Y; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
Wang J; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
Liu Y; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
Wu Z; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
Song E; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
Liu Q; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China. .; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 02; Vol. 11 (1), pp. 5513. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents, Hormonal/*pharmacology
Breast Neoplasms/*drug therapy
Cyclin D1/*genetics
RNA, Long Noncoding/*metabolism
Tamoxifen/*pharmacology
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents, Hormonal/therapeutic use ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Disease-Free Survival ; Drug Resistance, Neoplasm/genetics ; Female ; Follow-Up Studies ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Middle Aged ; Prognosis ; Protein Processing, Post-Translational/genetics ; Protein Stability ; Proteolysis ; RNA, Long Noncoding/genetics ; Tamoxifen/therapeutic use ; Xenograft Model Antitumor Assays ; Young Adult
Czasopismo naukowe
Tytuł :
Small grain and semi-dwarf 3, a WRKY transcription factor, negatively regulates plant height and grain size by stabilizing SLR1 expression in rice.
Autorzy :
Lan J; State Key Laboratory of Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University, Nanjing, 210095, China.
Lin Q; National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Zhou C; State Key Laboratory of Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University, Nanjing, 210095, China.
Ren Y; State Key Laboratory of Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University, Nanjing, 210095, China.
Liu X; State Key Laboratory of Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University, Nanjing, 210095, China.
Miao R; State Key Laboratory of Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University, Nanjing, 210095, China.
Jing R; State Key Laboratory of Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University, Nanjing, 210095, China.
Mou C; State Key Laboratory of Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University, Nanjing, 210095, China.
Nguyen T; State Key Laboratory of Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University, Nanjing, 210095, China.; Department of Biology and Agricultural Engineering, Quynhon University, Quynhon, Binhdinh, 590000, Vietnam.
Zhu X; State Key Laboratory of Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University, Nanjing, 210095, China.
Wang Q; State Key Laboratory of Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University, Nanjing, 210095, China.
Zhang X; National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Guo X; National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Liu S; State Key Laboratory of Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University, Nanjing, 210095, China.
Jiang L; State Key Laboratory of Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University, Nanjing, 210095, China. .
Wan J; State Key Laboratory of Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University, Nanjing, 210095, China. .; National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, 100081, China. .
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Źródło :
Plant molecular biology [Plant Mol Biol] 2020 Nov; Vol. 104 (4-5), pp. 429-450. Date of Electronic Publication: 2020 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
Oryza/*genetics
Oryza/*growth & development
Plant Proteins/*genetics
Transcription Factors/*genetics
5' Untranslated Regions ; DNA, Bacterial ; Gene Expression Regulation, Plant ; Gibberellins/metabolism ; Mutation ; Oryza/cytology ; Phenotype ; Plant Cells ; Plant Proteins/chemistry ; Plant Proteins/metabolism ; Plant Stems/cytology ; Plant Stems/genetics ; Promoter Regions, Genetic ; Protein Stability ; RNA Interference ; Seeds/genetics ; Seeds/growth & development ; Signal Transduction ; Transcription Factors/chemistry ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target.
Autorzy :
Dridi H; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Kushnir A; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Zalk R; The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Yuan Q; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Melville Z; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Marks AR; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. .
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Źródło :
Nature reviews. Cardiology [Nat Rev Cardiol] 2020 Nov; Vol. 17 (11), pp. 732-747. Date of Electronic Publication: 2020 Jun 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Atrial Fibrillation/*metabolism
Calcium/*metabolism
Heart Failure/*metabolism
Mitochondria, Heart/*metabolism
Myocytes, Cardiac/*metabolism
Ryanodine Receptor Calcium Release Channel/*metabolism
Tacrolimus Binding Proteins/*metabolism
Allosteric Regulation ; Animals ; Arrhythmias, Cardiac/metabolism ; Atrial Fibrillation/physiopathology ; Calcium Signaling ; Diastole ; Disease Progression ; Excitation Contraction Coupling ; Heart Failure/physiopathology ; Humans ; Mice ; Mutation ; Oxidation-Reduction ; Phosphorylation ; Protein Stability ; Ryanodine Receptor Calcium Release Channel/genetics ; Sarcoplasmic Reticulum/metabolism
Czasopismo naukowe
Tytuł :
ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population.
Autorzy :
Benetti E; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Tita R; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Spiga O; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
Ciolfi A; Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.
Birolo G; Department of Medical Sciences, University of Turin, Turin, Italy.
Bruselles A; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Doddato G; Medical Genetics, University of Siena, Siena, Italy.
Giliberti A; Medical Genetics, University of Siena, Siena, Italy.
Marconi C; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Musacchia F; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.
Pippucci T; Sant'Orsola-Malpighi University Hospital, Bologna, Italy.
Torella A; Dipartimento di Medicina di Precisione, Università della Campania 'Luigi Vanvitelli', Napoli, Italy.
Trezza A; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
Valentino F; Medical Genetics, University of Siena, Siena, Italy.
Baldassarri M; Medical Genetics, University of Siena, Siena, Italy.
Brusco A; Department of Medical Sciences, University of Turin, Turin, Italy.; Genetica Medica, Città della Salute e della Scienza, Torino, Italy.
Asselta R; Department of Biomedical Sciences, Humanitas University, Rozzano, Milan, Italy.; Humanitas Clinical and Research Center-IRCCS, Rozzano, Milan, Italy.
Bruttini M; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.; Medical Genetics, University of Siena, Siena, Italy.
Furini S; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Seri M; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.; Sant'Orsola-Malpighi University Hospital, Bologna, Italy.
Nigro V; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.; Dipartimento di Medicina di Precisione, Università della Campania 'Luigi Vanvitelli', Napoli, Italy.
Matullo G; Department of Medical Sciences, University of Turin, Turin, Italy.; Genetica Medica, Città della Salute e della Scienza, Torino, Italy.
Tartaglia M; Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.
Mari F; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.; Medical Genetics, University of Siena, Siena, Italy.
Renieri A; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy. .; Medical Genetics, University of Siena, Siena, Italy. .
Pinto AM; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
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Corporate Authors :
GEN-COVID Multicenter Study
Źródło :
European journal of human genetics : EJHG [Eur J Hum Genet] 2020 Nov; Vol. 28 (11), pp. 1602-1614. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronavirus Infections/*genetics
Peptidyl-Dipeptidase A/*genetics
Pneumonia, Viral/*genetics
Aged ; Betacoronavirus/chemistry ; Cohort Studies ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Databases, Genetic ; Female ; Frameshift Mutation ; Genetic Predisposition to Disease ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Molecular Dynamics Simulation ; Mutation, Missense ; Pandemics ; Peptidyl-Dipeptidase A/chemistry ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Protein Stability ; Spike Glycoprotein, Coronavirus/metabolism ; Whole Exome Sequencing
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Development of humanized tri-specific nanobodies with potent neutralization for SARS-CoV-2.
Autorzy :
Dong J; Ab Studio Inc., Hayward, CA, USA. .
Huang B; Ab Studio Inc., Hayward, CA, USA.
Wang B; Ab Studio Inc., Hayward, CA, USA.
Titong A; Ab Studio Inc., Hayward, CA, USA.
Gallolu Kankanamalage S; Ab Studio Inc., Hayward, CA, USA.
Jia Z; Ab Studio Inc., Hayward, CA, USA.
Wright M; Ab Studio Inc., Hayward, CA, USA.
Parthasarathy P; Ab Studio Inc., Hayward, CA, USA.
Liu Y; Ab Studio Inc., Hayward, CA, USA.; Ab Therapeutics Inc., Hayward, CA, USA.
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Źródło :
Scientific reports [Sci Rep] 2020 Oct 20; Vol. 10 (1), pp. 17806. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article
MeSH Terms :
Betacoronavirus/*metabolism
Single-Domain Antibodies/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Amino Acid Sequence ; Antigen-Antibody Reactions ; Betacoronavirus/isolation & purification ; Binding Sites ; Cell Line ; Computer-Aided Design ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Epitopes/chemistry ; Epitopes/immunology ; Humans ; Immunoglobulin Fc Fragments/genetics ; Immunoglobulin Fc Fragments/metabolism ; Molecular Docking Simulation ; Mutagenesis, Site-Directed ; Neutralization Tests ; Pandemics ; Peptide Library ; Peptidyl-Dipeptidase A/chemistry ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Protein Stability ; Single-Domain Antibodies/genetics ; Single-Domain Antibodies/metabolism ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression.
Autorzy :
Yip HYK; Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia.
Chee A; Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia.
Ang CS; Bio21 Mass Spectrometry and Proteomics Facility, The University of Melbourne, Parkville, VIC 3010, Australia.
Shin SY; Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia.
Ooms LM; Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia.
Mohammadi Z; Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia.
Phillips WA; Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia.
Daly RJ; Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia.
Cole TJ; Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia.
Bronson RT; Department of Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Nguyen LK; Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia.
Tiganis T; Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Hobbs RM; Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC 3800, Australia; Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.
McLean CA; Department of Anatomical Pathology, Alfred Hospital, Prahran, VIC 3181, Australia.
Mitchell CA; Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia.
Papa A; Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Oct 15; Vol. 80 (2), pp. 279-295.e8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mammary Neoplasms, Animal/*metabolism
Mammary Neoplasms, Animal/*pathology
PTEN Phosphohydrolase/*metabolism
Receptors, Glucocorticoid/*metabolism
Animals ; Carcinogenesis ; Cell Death ; Cell Line, Tumor ; Cell Proliferation ; Dexamethasone/pharmacology ; Female ; Humans ; Isoenzymes/metabolism ; Mice ; Models, Biological ; Mutation/genetics ; Organoids/pathology ; PTEN Phosphohydrolase/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Protein Stability ; Proteome/metabolism ; Proto-Oncogene Proteins c-akt/metabolism
Czasopismo naukowe
Tytuł :
Shifts and drifts in prion science.
Autorzy :
Aguzzi A; Institute of Neuropathology, University of Zürich, Rümistrasse 100, CH-8091 Zürich, Switzerland. .
De Cecco E; Institute of Neuropathology, University of Zürich, Rümistrasse 100, CH-8091 Zürich, Switzerland.
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Źródło :
Science (New York, N.Y.) [Science] 2020 Oct 02; Vol. 370 (6512), pp. 32-34.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Aggregates*
PrPSc Proteins/*biosynthesis
PrPSc Proteins/*chemistry
Prion Diseases/*transmission
Animals ; Cricetinae ; Humans ; Mice ; PrPSc Proteins/genetics ; Prion Diseases/metabolism ; Protein Conformation ; Protein Stability
Czasopismo naukowe

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