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Wyszukujesz frazę ""Protein Stability"" wg kryterium: Temat


Tytuł :
Understanding the Origins of Loss of Protein Function by Analyzing the Effects of Thousands of Variants on Activity and Abundance.
Autorzy :
Cagiada M; Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Johansson KE; Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Valanciute A; Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Nielsen SV; Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Hartmann-Petersen R; Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Yang JJ; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Fowler DM; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA.
Stein A; Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Lindorff-Larsen K; Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
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Źródło :
Molecular biology and evolution [Mol Biol Evol] 2021 Jul 29; Vol. 38 (8), pp. 3235-3246.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Substitution*
Protein Stability*
Structure-Activity Relationship*
PTEN Phosphohydrolase/*genetics
Pyrophosphatases/*genetics
Humans ; PTEN Phosphohydrolase/metabolism ; Protein Folding ; Pyrophosphatases/metabolism
Czasopismo naukowe
Tytuł :
Protease cleavage of RNF20 facilitates coronavirus replication via stabilization of SREBP1.
Autorzy :
Zhang S; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.
Wang J; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.; Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.; Suzhou Institute of System Medicine, Suzhou 215123, China.
Cheng G; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Sep 14; Vol. 118 (37).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Stability*
Virus Replication*
Coronavirus 3C Proteases/*metabolism
SARS-CoV-2/*pathogenicity
Sterol Regulatory Element Binding Protein 1/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Animals ; Antiviral Agents/pharmacology ; Cell Line ; Chlorocebus aethiops ; Gene Expression Regulation ; Interferons/physiology ; SARS-CoV-2/immunology ; Sterol Regulatory Element Binding Protein 1/antagonists & inhibitors ; Vero Cells
Czasopismo naukowe
Tytuł :
The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach.
Autorzy :
Romero-Romero S; Laboratorio de Fisicoquímica e Ingeniería de Proteínas, Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510 Mexico City, Mexico; Department of Biochemistry, University of Bayreuth, 95447 Bayreuth, Germany.
Costas M; Laboratorio de Biofisicoquímica, Departamento de Fisicoquímica, Facultad de Química, Universidad Nacional Autónoma de México, 04510 Mexico City, Mexico.
Silva Manzano DA; Department of Biochemistry, University of Washington, 98195 Seattle, USA; Institute for Protein Design, University of Washington, 98195 Seattle, USA.
Kordes S; Department of Biochemistry, University of Bayreuth, 95447 Bayreuth, Germany.
Rojas-Ortega E; Laboratorio de Fisicoquímica e Ingeniería de Proteínas, Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510 Mexico City, Mexico.
Tapia C; Laboratorio de Fisicoquímica e Ingeniería de Proteínas, Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510 Mexico City, Mexico.
Guerra Y; Laboratorio de Fisicoquímica e Ingeniería de Proteínas, Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510 Mexico City, Mexico.
Shanmugaratnam S; Department of Biochemistry, University of Bayreuth, 95447 Bayreuth, Germany.
Rodríguez-Romero A; Instituto de Química, Universidad Nacional Autónoma de México, 04510 Mexico City, Mexico.
Baker D; Department of Biochemistry, University of Washington, 98195 Seattle, USA; Institute for Protein Design, University of Washington, 98195 Seattle, USA. Electronic address: .
Höcker B; Department of Biochemistry, University of Bayreuth, 95447 Bayreuth, Germany. Electronic address: .
Fernández-Velasco DA; Laboratorio de Fisicoquímica e Ingeniería de Proteínas, Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510 Mexico City, Mexico. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Sep 03; Vol. 433 (18), pp. 167153. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Conformation, alpha-Helical*
Protein Conformation, beta-Strand*
Protein Folding*
Protein Stability*
Proteins/*chemistry
Evolution, Molecular ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Temperature
Czasopismo naukowe
Tytuł :
Thermostability of Ctenophore and Coelenterate Ca -Regulated Apo-photoproteins: A Comparative Study.
Autorzy :
Nemati R; Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran 14115-154, Iran.
Molakarimi M; Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran 14115-154, Iran.
Mohseni A; Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran 14115-154, Iran.
Taghdir M; Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran 14115-154, Iran.
Khalifeh K; Department of Biology, Faculty of Sciences, University of Zanjan, Zanjan 45371-38791, Iran.
H Sajedi R; Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran 14115-154, Iran.
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Źródło :
ACS chemical biology [ACS Chem Biol] 2021 Aug 20; Vol. 16 (8), pp. 1538-1545. Date of Electronic Publication: 2021 Jun 28.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Stability*
Cnidaria/*chemistry
Ctenophora/*chemistry
Luminescent Proteins/*chemistry
Animals ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Kinetics ; Molecular Dynamics Simulation ; Pliability ; Protein Conformation ; Thermodynamics
Czasopismo naukowe
Tytuł :
Community-Wide Experimental Evaluation of the PROSS Stability-Design Method.
Autorzy :
Peleg Y; Department of Life Sciences Core Facilities (LSCF), Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: .
Vincentelli R; Unité Mixte de Recherche (UMR) 7257, Centre National de la Recherche Scientifique (CNRS) Aix-Marseille Université, Architecture et Fonction des Macromolécules Biologiques (AFMB), Marseille, France.
Collins BM; The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Queensland 4072, Australia.
Chen KE; The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Queensland 4072, Australia.
Livingstone EK; The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Queensland 4072, Australia.
Weeratunga S; The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Queensland 4072, Australia.
Leneva N; The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Queensland 4072, Australia.
Guo Q; The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Queensland 4072, Australia.
Remans K; European Molecular Biology Laboratory (EMBL), Protein Expression and Purification Core Facility, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Perez K; European Molecular Biology Laboratory (EMBL), Protein Expression and Purification Core Facility, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Bjerga GEK; NORCE Norwegian Research Centre, Postboks 22 Nygårdstangen, 5038 Bergen, Norway.
Larsen Ø; NORCE Norwegian Research Centre, Postboks 22 Nygårdstangen, 5038 Bergen, Norway.
Vaněk O; Department of Biochemistry, Faculty of Science, Charles University, Hlavova 2030/8, 12840 Prague, Czech Republic.
Skořepa O; Department of Biochemistry, Faculty of Science, Charles University, Hlavova 2030/8, 12840 Prague, Czech Republic.
Jacquemin S; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS), UMR 7104, Institut National de la Santé et de la Recherche Médicale (INSERM), U1258, Université de Strasbourg, France.
Poterszman A; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS), UMR 7104, Institut National de la Santé et de la Recherche Médicale (INSERM), U1258, Université de Strasbourg, France.
Kjær S; Structural Biology Science Technology Platform, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Christodoulou E; Structural Biology Science Technology Platform, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Albeck S; Department of Life Sciences Core Facilities (LSCF), Weizmann Institute of Science, Rehovot 7610001, Israel.
Dym O; Department of Life Sciences Core Facilities (LSCF), Weizmann Institute of Science, Rehovot 7610001, Israel.
Ainbinder E; Department of Life Sciences Core Facilities (LSCF), Weizmann Institute of Science, Rehovot 7610001, Israel.
Unger T; Department of Life Sciences Core Facilities (LSCF), Weizmann Institute of Science, Rehovot 7610001, Israel.
Schuetz A; Max-Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany.
Matthes S; Max-Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany.
Bader M; Max-Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany; University of Lübeck, Institute for Biology, Ratzeburger Allee 160, 23562 Lübeck, Germany; Charité University Medicine, Charitéplatz 1, 10117 Berlin, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany.
de Marco A; Laboratory for Environmental and Life Sciences, University of Nova Gorica, Slovenia.
Storici P; Elettra Sincrotrone Trieste - SS 14 - km 163, 5 in Area Science Park, 34149 Basovizza, Trieste, Italy.
Semrau MS; Elettra Sincrotrone Trieste - SS 14 - km 163, 5 in Area Science Park, 34149 Basovizza, Trieste, Italy.
Stolt-Bergner P; Vienna Biocenter Core Facilities GmbH, Dr. Bohr-gasse 3, 1030 Vienna, Austria.
Aigner C; Vienna Biocenter Core Facilities GmbH, Dr. Bohr-gasse 3, 1030 Vienna, Austria.
Suppmann S; Max-Planck Institute of Biochemistry, Biochemistry Core Facility, Am Klopferspitz 18, 82152 Martinsried, Germany.
Goldenzweig A; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.
Fleishman SJ; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Jun 25; Vol. 433 (13), pp. 166964. Date of Electronic Publication: 2021 Mar 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Algorithms*
Protein Stability*
Animals ; Escherichia coli/metabolism ; HEK293 Cells ; High-Throughput Screening Assays ; Humans ; Models, Molecular ; Proteins/chemistry ; Proteins/metabolism ; Solubility ; Temperature ; Zebrafish
Czasopismo naukowe
Tytuł :
A Deep-Learning Sequence-Based Method to Predict Protein Stability Changes Upon Genetic Variations.
Autorzy :
Pancotti C; Department of Medical Science, University of Turin, Via Santena 19, 10126 Torino, Italy.
Benevenuta S; Department of Medical Science, University of Turin, Via Santena 19, 10126 Torino, Italy.
Repetto V; Department of Medical Science, University of Turin, Via Santena 19, 10126 Torino, Italy.
Birolo G; Department of Medical Science, University of Turin, Via Santena 19, 10126 Torino, Italy.
Capriotti E; Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via Francesco Selmi 3, 40126 Bologna, Italy.
Sanavia T; Department of Medical Science, University of Turin, Via Santena 19, 10126 Torino, Italy.
Fariselli P; Department of Medical Science, University of Turin, Via Santena 19, 10126 Torino, Italy.
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Źródło :
Genes [Genes (Basel)] 2021 Jun 12; Vol. 12 (6). Date of Electronic Publication: 2021 Jun 12.
Typ publikacji :
Journal Article
MeSH Terms :
Deep Learning*
Genetic Variation*
Protein Stability*
Sequence Analysis, Protein/*methods
Amino Acid Substitution ; Humans ; Molecular Dynamics Simulation
Czasopismo naukowe
Tytuł :
Standard operating procedure for fluorescent thermal shift assay (FTSA) for determination of protein-ligand binding and protein stability.
Autorzy :
Kazlauskas E; Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio 7, 10257, Vilnius, Lithuania.
Petrauskas V; Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio 7, 10257, Vilnius, Lithuania.
Paketurytė V; Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio 7, 10257, Vilnius, Lithuania.
Matulis D; Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio 7, 10257, Vilnius, Lithuania. .
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Źródło :
European biophysics journal : EBJ [Eur Biophys J] 2021 May; Vol. 50 (3-4), pp. 373-379. Date of Electronic Publication: 2021 Apr 29.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Stability*
Ligands ; Protein Binding ; Proteins/metabolism
Czasopismo naukowe
Tytuł :
Perturbing the energy landscape for improved packing during computational protein design.
Autorzy :
Maguire JB; Program in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Haddox HK; Department of Biochemistry, University of Washington, Seattle, Washington, USA.; Institute for Protein Design, University of Washington, Seattle, Washington, USA.
Strickland D; Department of Electrical and Computer Engineering, University of Washington, Seattle, Washington, USA.
Halabiya SF; Department of Electrical and Computer Engineering, University of Washington, Seattle, Washington, USA.
Coventry B; Institute for Protein Design, University of Washington, Seattle, Washington, USA.; Molecular Engineering PhD Program, University of Washington, Seattle, Washington, USA.
Griffin JR; Department of Chemistry, State University of New York at Buffalo, Buffalo, New York, USA.
Pulavarti SVSRK; Department of Chemistry, State University of New York at Buffalo, Buffalo, New York, USA.
Cummins M; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Thieker DF; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Klavins E; Department of Electrical and Computer Engineering, University of Washington, Seattle, Washington, USA.
Szyperski T; Department of Chemistry, State University of New York at Buffalo, Buffalo, New York, USA.
DiMaio F; Department of Biochemistry, University of Washington, Seattle, Washington, USA.; Institute for Protein Design, University of Washington, Seattle, Washington, USA.
Baker D; Department of Biochemistry, University of Washington, Seattle, Washington, USA.; Institute for Protein Design, University of Washington, Seattle, Washington, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, Washington, USA.
Kuhlman B; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
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Źródło :
Proteins [Proteins] 2021 Apr; Vol. 89 (4), pp. 436-449. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Protein Conformation*
Protein Folding*
Protein Stability*
Computational Biology/*methods
Proteins/*chemistry
Databases, Protein ; Hydrophobic and Hydrophilic Interactions ; Protein Engineering
Czasopismo naukowe
Tytuł :
A Bayesian semi-parametric model for thermal proteome profiling.
Autorzy :
Fang S; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK.; Milner Therapeutics Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
Kirk PDW; MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.
Bantscheff M; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany.
Lilley KS; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK. .; Milner Therapeutics Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK. .
Crook OM; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK. .; MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK. .; Milner Therapeutics Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK. .
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Źródło :
Communications biology [Commun Biol] 2021 Jun 29; Vol. 4 (1), pp. 810. Date of Electronic Publication: 2021 Jun 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bayes Theorem*
Protein Stability*
Proteome*
Solubility ; Temperature ; Thermodynamics
Czasopismo naukowe
Tytuł :
Freeze-thaw characterization process to minimize aggregation and enable drug product manufacturing of protein based therapeutics.
Autorzy :
Jain K; Takeda Pharmaceutical Company Limited, 200 Shire Way, Lexington, MA, 02421, USA. .
Salamat-Miller N; Takeda Pharmaceutical Company Limited, 200 Shire Way, Lexington, MA, 02421, USA.
Taylor K; Takeda Pharmaceutical Company Limited, 200 Shire Way, Lexington, MA, 02421, USA.
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Źródło :
Scientific reports [Sci Rep] 2021 May 31; Vol. 11 (1), pp. 11332. Date of Electronic Publication: 2021 May 31.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal*
Freezing*
Protein Aggregates*
Protein Stability*
Czasopismo naukowe
Tytuł :
Predicting the stability of mutant proteins by computational approaches: an overview.
Autorzy :
Marabotti A; University of Salerno.
Scafuri B; University of Salerno.
Facchiano A; Institute of Food Sciences, CNR Italy.
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Źródło :
Briefings in bioinformatics [Brief Bioinform] 2021 May 20; Vol. 22 (3).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Mutation*
Protein Stability*
Computational Biology/*methods
Proteins/*chemistry
Genetic Diseases, Inborn/genetics ; Humans ; Proteins/genetics ; Thermodynamics
Czasopismo naukowe
Tytuł :
An enzyme-based biosensor for monitoring and engineering protein stability in vivo.
Autorzy :
Ren C; State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, Shanghai 200237, China.
Wen X; State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, Shanghai 200237, China.
Mencius J; State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, Shanghai 200237, China.
Quan S; State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, Shanghai 200237, China .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Mar 30; Vol. 118 (13).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biosensing Techniques*
Protein Engineering*
Protein Stability*
Directed Molecular Evolution/*methods
Methyltransferases/*chemistry
Acid Anhydride Hydrolases/chemistry ; Acid Anhydride Hydrolases/genetics ; Catalytic Domain ; Escherichia coli ; Fluorescence ; High-Throughput Screening Assays ; Humans ; Methyltransferases/genetics ; Mutation
Czasopismo naukowe
Tytuł :
A base measure of precision for protein stability predictors: structural sensitivity.
Autorzy :
Caldararu O; DTU Chemistry, Technical University of Denmark, Building 206, 2800, Kgs. Lyngby, Denmark.
Blundell TL; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK.
Kepp KP; DTU Chemistry, Technical University of Denmark, Building 206, 2800, Kgs. Lyngby, Denmark. .
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2021 Feb 25; Vol. 22 (1), pp. 88. Date of Electronic Publication: 2021 Feb 25.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Engineering*
Protein Stability*
Proteins*/genetics
Mutagenesis ; Thermodynamics
Czasopismo naukowe
Tytuł :
Improved dual luciferase reporter (DLR) assay to determine the protein stability.
Autorzy :
Sun Y; National Key Facility for Crop Gene Resources and Genetic Improvement, ICS, CAAS, 12 Zhongguancun South Street, Haidian District, Beijing, 100081, China. Electronic address: .
Zhao J; National Key Facility for Crop Gene Resources and Genetic Improvement, ICS, CAAS, 12 Zhongguancun South Street, Haidian District, Beijing, 100081, China. Electronic address: .
Patil SB; National Key Facility for Crop Gene Resources and Genetic Improvement, ICS, CAAS, 12 Zhongguancun South Street, Haidian District, Beijing, 100081, China. Electronic address: .
Fang J; National Key Facility for Crop Gene Resources and Genetic Improvement, ICS, CAAS, 12 Zhongguancun South Street, Haidian District, Beijing, 100081, China. Electronic address: .
Liu J; National Key Facility for Crop Gene Resources and Genetic Improvement, ICS, CAAS, 12 Zhongguancun South Street, Haidian District, Beijing, 100081, China. Electronic address: .
Li X; National Key Facility for Crop Gene Resources and Genetic Improvement, ICS, CAAS, 12 Zhongguancun South Street, Haidian District, Beijing, 100081, China. Electronic address: .
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Źródło :
Analytical biochemistry [Anal Biochem] 2021 Jan 01; Vol. 612, pp. 114021. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Reporter*
Protein Stability*
Biological Assay/*methods
Luciferases/*metabolism
Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Genetic Vectors ; Heterocyclic Compounds, 3-Ring/pharmacology ; Indicators and Reagents/chemistry ; Lactones/pharmacology ; Luciferases, Firefly/genetics ; Luciferases, Renilla/genetics ; Oryza/metabolism ; Plant Growth Regulators/genetics ; Plant Growth Regulators/metabolism ; Plant Leaves/metabolism ; Protoplasts/metabolism ; Tobacco/metabolism
Czasopismo naukowe
Tytuł :
Stabilizing or Destabilizing: Simulations of Chymotrypsin Inhibitor 2 under Crowding Reveal Existence of a Crossover Temperature.
Autorzy :
Timr S; CNRS, Université de Paris, UPR 9080, Laboratoire de Biochimie Théorique, 13 rue Pierre et Marie Curie, F-75005, Paris, France.; Institut de Biologie Physico-Chimique-Fondation Edmond de Rothschild, PSL Research University, Paris, France.
Sterpone F; CNRS, Université de Paris, UPR 9080, Laboratoire de Biochimie Théorique, 13 rue Pierre et Marie Curie, F-75005, Paris, France.; Institut de Biologie Physico-Chimique-Fondation Edmond de Rothschild, PSL Research University, Paris, France.
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Źródło :
The journal of physical chemistry letters [J Phys Chem Lett] 2021 Feb 18; Vol. 12 (6), pp. 1741-1746. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article
MeSH Terms :
Computer Simulation*
Protein Stability*
Temperature*
Peptides/*chemistry
Plant Proteins/*chemistry
Hydrophobic and Hydrophilic Interactions ; Serum Albumin, Bovine/chemistry ; Thermodynamics
Czasopismo naukowe
Tytuł :
Origin of the Surprising Mechanical Stability of Kinesin's Neck Coiled Coil.
Autorzy :
Liu SX; Institute of Biophysics, Hebei University of Technology, Tianjin 300401, China.
Lü G; Mathematical and Physical Science School, North China Electric Power University, Baoding 071003, China.
Zhang H; School of Science, Hebei University of Technology, Tianjin 300401, China.
Geng YZ; Institute of Biophysics, Hebei University of Technology, Tianjin 300401, China.; School of Science, Hebei University of Technology, Tianjin 300401, China.
Ji Q; Institute of Biophysics, Hebei University of Technology, Tianjin 300401, China.; School of Science, Hebei University of Technology, Tianjin 300401, China.; State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, China.
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Źródło :
Journal of chemical theory and computation [J Chem Theory Comput] 2021 Feb 09; Vol. 17 (2), pp. 1017-1029. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Stability*
Kinesin/*chemistry
Computer Simulation ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Protein Domains ; Protein Structure, Secondary
Czasopismo naukowe
Tytuł :
SARS-CoV-2 infection remodels the host protein thermal stability landscape.
Autorzy :
Selkrig J; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Stanifer M; Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital, Heidelberg, Germany.
Mateus A; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Mitosch K; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Barrio-Hernandez I; European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Rettel M; Proteomics Core Facility, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Kim H; Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital, Heidelberg, Germany.
Voogdt CGP; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Walch P; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.; Faculty of Biosciences, EMBL and Heidelberg University, Heidelberg, Germany.
Kee C; Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital, Heidelberg, Germany.
Kurzawa N; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.; Faculty of Biosciences, EMBL and Heidelberg University, Heidelberg, Germany.
Stein F; Proteomics Core Facility, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Potel C; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Jarzab A; Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
Kuster B; Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
Bartenschlager R; Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital, Heidelberg, Germany.; Division 'Virus-associated Carcinogenesis', German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Center for Infection Research, Heidelberg Partner site, Heidelberg, Germany.
Boulant S; Department of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany.; Research Group 'Cellular Polarity and Viral Infection', German Cancer Research Center (DKFZ), Heidelberg, Germany.
Beltrao P; European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Typas A; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Savitski MM; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
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Źródło :
Molecular systems biology [Mol Syst Biol] 2021 Feb; Vol. 17 (2), pp. e10188.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Host-Pathogen Interactions*
Protein Stability*
COVID-19/*metabolism
SARS-CoV-2/*physiology
Viral Proteins/*metabolism
Antiviral Agents/pharmacology ; COVID-19/virology ; Humans ; Proteome ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/metabolism ; Temperature ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
The Challenge of Peptide Proteolytic Stability Studies: Scarce Data, Difficult Readability, and the Need for Harmonization.
Autorzy :
Cavaco M; Department of Biochemistry, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof Egas Moniz, 1649-028, Lisboa, Portugal.; Proteomics and Protein Chemistry Unit, Department of Experimental and Health Sciences, Pompeu Fabra University, Dr Aiguader 88, Barcelona Biomedical Research Park, 08003, Barcelona, Spain.
Andreu D; Proteomics and Protein Chemistry Unit, Department of Experimental and Health Sciences, Pompeu Fabra University, Dr Aiguader 88, Barcelona Biomedical Research Park, 08003, Barcelona, Spain.
Castanho MARB; Department of Biochemistry, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof Egas Moniz, 1649-028, Lisboa, Portugal.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Jan 25; Vol. 60 (4), pp. 1686-1688. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Stability*
Peptides/*chemistry
Animals ; Humans ; Proteolysis
Czasopismo naukowe
Tytuł :
Protein Folding Stability Changes Across the Proteome Reveal Targets of Cu Toxicity in E. coli .
Autorzy :
Wiebelhaus N; Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708, United States.
Zaengle-Barone JM; Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708, United States.
Hwang KK; Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708, United States.
Franz KJ; Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708, United States.
Fitzgerald MC; Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708, United States.
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Źródło :
ACS chemical biology [ACS Chem Biol] 2021 Jan 15; Vol. 16 (1), pp. 214-224. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Protein Folding*
Protein Stability*
Copper/*toxicity
Escherichia coli/*drug effects
Proteome/*chemistry
Escherichia coli/metabolism
Czasopismo naukowe
Tytuł :
SAAFEC-SEQ: A Sequence-Based Method for Predicting the Effect of Single Point Mutations on Protein Thermodynamic Stability.
Autorzy :
Li G; Department of Physics and Astronomy, Clemson University, Clemson, SC 29634, USA.
Panday SK; Department of Physics and Astronomy, Clemson University, Clemson, SC 29634, USA.
Alexov E; Department of Physics and Astronomy, Clemson University, Clemson, SC 29634, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 09; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 09.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Stability*
Proteins/*chemistry
Amino Acid Substitution ; Humans ; Machine Learning ; Point Mutation ; Proteins/genetics ; Software ; Thermodynamics
Czasopismo naukowe

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