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Tytuł:
A base measure of precision for protein stability predictors: structural sensitivity.
Autorzy:
Caldararu O; DTU Chemistry, Technical University of Denmark, Building 206, 2800, Kgs. Lyngby, Denmark.
Blundell TL; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK.
Kepp KP; DTU Chemistry, Technical University of Denmark, Building 206, 2800, Kgs. Lyngby, Denmark. .
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Źródło:
BMC bioinformatics [BMC Bioinformatics] 2021 Feb 25; Vol. 22 (1), pp. 88. Date of Electronic Publication: 2021 Feb 25.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Engineering*
Protein Stability*
Proteins*/genetics
Mutagenesis ; Thermodynamics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
IMPROvER: the Integral Membrane Protein Stability Selector.
Autorzy:
Harborne SPD; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK. .; Peak Proteins, BioHub, Alderley Park, Macclesfield, UK. .
Strauss J; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK.
Boakes JC; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK.
Wright DL; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK.
Henderson JG; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK.
Boivineau J; Novartis Institutes for Biomedical Research, Chemical Biology and Therapeutics, Virchow 16, Basel, Switzerland.
Jaakola VP; Confo Therapeutics, Technologiepark 94, 9052, Zwijnaarde, Belgium.
Goldman A; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK. .; MIBS, Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland. .
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Źródło:
Scientific reports [Sci Rep] 2020 Sep 16; Vol. 10 (1), pp. 15165. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Engineering*
Protein Stability*
Software*
Membrane Proteins/*chemistry
Membrane Proteins/*genetics
Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Clostridium/chemistry ; Clostridium/genetics ; Computer Simulation ; Equilibrative Nucleoside Transporter 1/chemistry ; Equilibrative Nucleoside Transporter 1/genetics ; Genetic Variation ; High-Throughput Nucleotide Sequencing ; Humans ; Models, Molecular ; Protein Conformation, alpha-Helical/genetics ; Protein Denaturation ; Pyrophosphatases/chemistry ; Pyrophosphatases/genetics ; Receptor, Parathyroid Hormone, Type 1/chemistry ; Receptors, G-Protein-Coupled/chemistry ; Receptors, G-Protein-Coupled/genetics ; Sequence Alignment ; Sequence Analysis, Protein ; Structural Homology, Protein
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Improvement of Biophysical Properties and Affinity of a Human Anti-L1CAM Therapeutic Antibody through Antibody Engineering Based on Computational Methods.
Autorzy:
Chae H; Department of Systems Immunology, Kangwon National University, Chuncheon 24341, Korea.; APIT BIO Inc., B910, Munjeongdong Tera Tower, 167 Songpa-daero, Songpa-gu, Seoul 05855, Korea.
Cho S; Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341, Korea.
Jeong M; Department of Systems Immunology, Kangwon National University, Chuncheon 24341, Korea.
Kwon K; Department of Systems Immunology, Kangwon National University, Chuncheon 24341, Korea.
Choi D; Division of Drug Process Development, New Drug Development Center, Osong Medical Innovation Foundation, Chungcheongbuk-do, Cheongju-si 28160, Korea.
Lee J; APIT BIO Inc., B910, Munjeongdong Tera Tower, 167 Songpa-daero, Songpa-gu, Seoul 05855, Korea.
Nam W; APIT BIO Inc., B910, Munjeongdong Tera Tower, 167 Songpa-daero, Songpa-gu, Seoul 05855, Korea.
Hong J; Department of Systems Immunology, Kangwon National University, Chuncheon 24341, Korea.
Lee J; Department of Systems Immunology, Kangwon National University, Chuncheon 24341, Korea.
Yoon S; APIT BIO Inc., B910, Munjeongdong Tera Tower, 167 Songpa-daero, Songpa-gu, Seoul 05855, Korea.
Hong H; Department of Systems Immunology, Kangwon National University, Chuncheon 24341, Korea.; Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 22; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 22.
Typ publikacji:
Journal Article
MeSH Terms:
Models, Molecular*
Protein Engineering*/methods
Antibodies, Monoclonal/*chemistry
Neural Cell Adhesion Molecule L1/*chemistry
Animals ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/pharmacology ; Antibody Affinity ; CHO Cells ; Chemical Phenomena ; Cricetulus ; Drug Design ; Drug Evaluation, Preclinical ; Humans ; Neural Cell Adhesion Molecule L1/antagonists & inhibitors ; Protein Stability ; Thermodynamics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Rational thermostabilisation of four-helix bundle dimeric de novo proteins.
Autorzy:
Irumagawa S; Department of Science and Technology, Graduate School of Medicine, Science and Technology, Shinshu University, Ueda, Nagano, 386-8567, Japan.; Department of Biomolecular Innovation, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, Matsumoto, Nagano, 390-8621, Japan.; Department of Applied Biology, Faculty of Textile Science and Technology, Shinshu University, Ueda, Nagano, 386-8567, Japan.
Kobayashi K; Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, 135-0064, Japan.
Saito Y; Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, 135-0064, Japan.; AIST-Waseda University Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL), Tokyo, 169-8555, Japan.; Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, 277-8561, Japan.
Miyata T; Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima, 890-0065, Japan.
Umetsu M; Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan.
Kameda T; Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, 135-0064, Japan.
Arai R; Department of Science and Technology, Graduate School of Medicine, Science and Technology, Shinshu University, Ueda, Nagano, 386-8567, Japan. .; Department of Biomolecular Innovation, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, Matsumoto, Nagano, 390-8621, Japan. .; Department of Applied Biology, Faculty of Textile Science and Technology, Shinshu University, Ueda, Nagano, 386-8567, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2021 Apr 06; Vol. 11 (1), pp. 7526. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Conformation, alpha-Helical/*genetics
Protein Engineering/*methods
Protein Structure, Secondary/*genetics
Amino Acid Sequence/genetics ; Molecular Dynamics Simulation ; Mutagenesis, Site-Directed/methods ; Protein Denaturation ; Protein Stability ; Protein Structure, Secondary/physiology ; Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
De novo design of transmembrane β barrels.
Autorzy:
Vorobieva AA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
White P; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, USA.
Liang B; Department of Molecular Physiology and Biological Physics and Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA 22903, USA.
Horne JE; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, USA.
Bera AK; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Chow CM; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Gerben S; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Marx S; Department of Molecular Engineering and Sciences, University of Washington, Seattle, WA 98195, USA.
Kang A; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Stiving AQ; Department of Chemistry and Biochemistry, Resource for Native Mass Spectrometry Guided Structural Biology, The Ohio State University, Columbus, OH 43210, USA.
Harvey SR; Department of Chemistry and Biochemistry, Resource for Native Mass Spectrometry Guided Structural Biology, The Ohio State University, Columbus, OH 43210, USA.
Marx DC; TC Jenkins Department of Biophysics Johns Hopkins University, Baltimore, MD 21218, USA.
Khan GN; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, USA.
Fleming KG; TC Jenkins Department of Biophysics Johns Hopkins University, Baltimore, MD 21218, USA.
Wysocki VH; Department of Chemistry and Biochemistry, Resource for Native Mass Spectrometry Guided Structural Biology, The Ohio State University, Columbus, OH 43210, USA.
Brockwell DJ; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, USA.
Tamm LK; Department of Molecular Physiology and Biological Physics and Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA 22903, USA.
Radford SE; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, USA.
Baker D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. .; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2021 Feb 19; Vol. 371 (6531).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Computer Simulation*
Models, Molecular*
Protein Conformation, beta-Strand*
Protein Engineering*
Membrane Proteins/*chemistry
Amino Acid Sequence ; Crystallography, X-Ray ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Lipid Bilayers ; Magnetic Resonance Spectroscopy ; Membranes, Artificial ; Micelles ; Protein Conformation ; Protein Folding ; Protein Stability
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Increasing thermal stability and improving biodistribution of VEGFR2-binding affibody molecules by a combination of in silico and directed evolution approaches.
Autorzy:
Güler R; Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.
Svedmark SF; Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.
Abouzayed A; Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Orlova A; Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.; Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia.
Löfblom J; Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden. .
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Źródło:
Scientific reports [Sci Rep] 2020 Oct 23; Vol. 10 (1), pp. 18148. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Engineering*
Recombinant Fusion Proteins*/administration & dosage
Recombinant Fusion Proteins*/chemistry
Recombinant Fusion Proteins*/genetics
Recombinant Fusion Proteins*/pharmacokinetics
Vascular Endothelial Growth Factor Receptor-2/*antagonists & inhibitors
Animals ; Computer Simulation ; Directed Molecular Evolution ; Female ; Flow Cytometry ; Hot Temperature/adverse effects ; Mice ; Models, Animal ; Mutation ; Peptide Library ; Protein Binding ; Protein Stability ; Tissue Distribution
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dodecin as carrier protein for immunizations and bioengineering applications.
Autorzy:
Bourdeaux F; Institute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Cluster of Excellence for Macromolecular Complexes, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438, Frankfurt am Main, Germany.
Kopp Y; Institute of Biophysical Chemistry, Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Max-von-Lauer Str. 15, 60438, Frankfurt am Main, Germany.
Lautenschläger J; Institute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Cluster of Excellence for Macromolecular Complexes, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438, Frankfurt am Main, Germany.
Gößner I; Institute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Cluster of Excellence for Macromolecular Complexes, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438, Frankfurt am Main, Germany.
Besir H; European Molecular Biology Laboratory, 69117, Heidelberg, Germany.; PROGEN Biotechnik GmbH, 69123, Heidelberg, Germany.
Vabulas RM; Institute of Biochemistry, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Grininger M; Institute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Cluster of Excellence for Macromolecular Complexes, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438, Frankfurt am Main, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2020 Aug 06; Vol. 10 (1), pp. 13297. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Engineering*
Bacterial Proteins/*genetics
Bacterial Proteins/*immunology
Immunization/*methods
Bacterial Proteins/chemistry ; Mycobacterium tuberculosis/genetics ; Protein Domains ; Protein Stability ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Engineering a disulfide-gated switch in streptavidin enables reversible binding without sacrificing binding affinity.
Autorzy:
Marangoni JM; Department of Biological Sciences, University of Calgary, Calgary, AB, T2N 1N4, Canada.
Wu SC; Department of Biological Sciences, University of Calgary, Calgary, AB, T2N 1N4, Canada.
Fogen D; Department of Biological Sciences, University of Calgary, Calgary, AB, T2N 1N4, Canada.; Department of Molecular Biosciences and Bioengineering, University of Hawaii, Honolulu, HI, 96822, USA.
Wong SL; Department of Biological Sciences, University of Calgary, Calgary, AB, T2N 1N4, Canada.
Ng KKS; Department of Biological Sciences, University of Calgary, Calgary, AB, T2N 1N4, Canada. .
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Źródło:
Scientific reports [Sci Rep] 2020 Jul 27; Vol. 10 (1), pp. 12483. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Protein Engineering*
Disulfides/*chemistry
Streptavidin/*chemistry
Binding Sites ; Biotin/chemistry ; Crystallography, X-Ray ; Fluorescein/chemistry ; Kinetics ; Models, Molecular ; Mutant Proteins/chemistry ; Oxidation-Reduction ; Protein Binding ; Protein Stability ; Temperature
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Albumin-neprilysin fusion protein: understanding stability using small angle X-ray scattering and molecular dynamic simulations.
Autorzy:
Kulakova A; Department of Chemistry, Technical University of Denmark, Kemitorvet building 207, Kgs. Lyngby, 2800, Denmark.
Indrakumar S; Department of Chemistry, Technical University of Denmark, Kemitorvet building 207, Kgs. Lyngby, 2800, Denmark.
Sønderby Tuelung P; Department of Chemistry, Technical University of Denmark, Kemitorvet building 207, Kgs. Lyngby, 2800, Denmark.
Mahapatra S; Novozymes A/S, Biologiens Vej 2, 2800, Kgs. Lyngby, Denmark.
Streicher WW; Novozymes A/S, Biologiens Vej 2, 2800, Kgs. Lyngby, Denmark.
Peters GHJ; Department of Chemistry, Technical University of Denmark, Kemitorvet building 207, Kgs. Lyngby, 2800, Denmark.
Harris P; Department of Chemistry, Technical University of Denmark, Kemitorvet building 207, Kgs. Lyngby, 2800, Denmark. .
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Źródło:
Scientific reports [Sci Rep] 2020 Jun 22; Vol. 10 (1), pp. 10089. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neprilysin/*chemistry
Protein Engineering/*methods
Serum Albumin, Human/*chemistry
Albumins/chemistry ; Hydrogen-Ion Concentration ; Molecular Dynamics Simulation ; Protein Conformation ; Protein Stability/drug effects ; Scattering, Small Angle ; X-Ray Diffraction/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
ProtDataTherm: A database for thermostability analysis and engineering of proteins.
Autorzy:
Pezeshgi Modarres H; BioMEMS and Bioinspired Microfluidic Laboratory, Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, Alberta, Canada.; Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California Berkeley, 208A Stanley Hall, Berkeley, CA, United States of America.; School of Biological Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.
Mofrad MR; Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California Berkeley, 208A Stanley Hall, Berkeley, CA, United States of America.; Physical Biosciences Division, Lawrence Berkeley National Lab, Berkeley, CA, United States of America.
Sanati-Nezhad A; BioMEMS and Bioinspired Microfluidic Laboratory, Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, Alberta, Canada.; Center for BioEngineering Research and Education, University of Calgary, Alberta, Canada.
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Źródło:
PloS one [PLoS One] 2018 Jan 29; Vol. 13 (1), pp. e0191222. Date of Electronic Publication: 2018 Jan 29 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Databases, Protein*
Protein Engineering*
Protein Stability*
Algorithms ; Amino Acid Sequence ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Hot Temperature ; Models, Molecular ; Mutation ; Thermodynamics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Selection, characterization, and thermal stabilization of llama single domain antibodies towards Ebola virus glycoprotein.
Autorzy:
Liu JL; US Naval Research Laboratory, Center for Bio/Molecular Science and Engineering, 4555 Overlook Ave SW, Washington, DC, 20375, USA.
Shriver-Lake LC; US Naval Research Laboratory, Center for Bio/Molecular Science and Engineering, 4555 Overlook Ave SW, Washington, DC, 20375, USA.
Anderson GP; US Naval Research Laboratory, Center for Bio/Molecular Science and Engineering, 4555 Overlook Ave SW, Washington, DC, 20375, USA.
Zabetakis D; US Naval Research Laboratory, Center for Bio/Molecular Science and Engineering, 4555 Overlook Ave SW, Washington, DC, 20375, USA.
Goldman ER; US Naval Research Laboratory, Center for Bio/Molecular Science and Engineering, 4555 Overlook Ave SW, Washington, DC, 20375, USA. .
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Źródło:
Microbial cell factories [Microb Cell Fact] 2017 Dec 12; Vol. 16 (1), pp. 223. Date of Electronic Publication: 2017 Dec 12.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Stability*
Ebolavirus/*immunology
Protein Engineering/*methods
Single-Domain Antibodies/*immunology
Single-Domain Antibodies/*isolation & purification
Viral Envelope Proteins/*immunology
Animals ; Camelids, New World ; Ebolavirus/chemistry ; Hemorrhagic Fever, Ebola/diagnosis ; Hemorrhagic Fever, Ebola/therapy ; Humans ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Heavy Chains/immunology ; Immunoglobulin Heavy Chains/isolation & purification ; Immunoglobulin Heavy Chains/metabolism ; Peptide Library ; Protein Binding ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Refrigeration ; Single-Domain Antibodies/genetics ; Single-Domain Antibodies/metabolism ; Temperature ; Viral Envelope Proteins/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Bioengineering oligomerization and monomerization of enzymes: learning from natural evolution to matching the demands for industrial applications.
Autorzy:
Liu H; Institute for Synthetic Biosystem, Department of Biochemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, China.
Cao M; Institute for Synthetic Biosystem, Department of Biochemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, China.
Wang Y; Institute for Synthetic Biosystem, Department of Biochemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, China.
Lv B; Institute for Synthetic Biosystem, Department of Biochemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, China.
Li C; Institute for Synthetic Biosystem, Department of Biochemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, China.
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Źródło:
Critical reviews in biotechnology [Crit Rev Biotechnol] 2020 Mar; Vol. 40 (2), pp. 231-246. Date of Electronic Publication: 2020 Jan 08.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Engineering*
Enzymes/*genetics
Bioengineering ; Catalysis ; Enzymes/chemistry ; Enzymes/metabolism ; Protein Stability
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Protein Engineering of Multi-Modular Transcription Factor Alcohol Dehydrogenase Repressor 1 (Adr1p), a Tool for Dissecting In Vitro Transcription Activation.
Autorzy:
Buttinelli M; Department of Biology and Biotechnology 'Charles Darwin', Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Panetta G; Department of Biochemical Sciences, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Bucci A; Department of Biology and Biotechnology 'Charles Darwin', Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.; Department of Biochemical Sciences, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Frascaria D; Department of Biology and Biotechnology 'Charles Darwin', Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Morea V; National Research Council of Italy (CNR), Institute of Molecular Biology and Pathology, P.le Aldo Moro 5, 00185 Rome, Italy.
Miele AE; Department of Biochemical Sciences, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy. .f.; Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), UMR 5246 CNRS - UCBL - Université de Lyon, 43 boulevard du 11 Novembre 1918, 69622 Villeurbanne, France. .f.
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Źródło:
Biomolecules [Biomolecules] 2019 Sep 17; Vol. 9 (9). Date of Electronic Publication: 2019 Sep 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alcohol Dehydrogenase/*genetics
DNA-Binding Proteins/*chemistry
DNA-Binding Proteins/*metabolism
Protein Engineering/*methods
Saccharomyces cerevisiae/*enzymology
Saccharomyces cerevisiae Proteins/*chemistry
Saccharomyces cerevisiae Proteins/*genetics
Saccharomyces cerevisiae Proteins/*metabolism
Transcription Factors/*chemistry
Transcription Factors/*metabolism
Alcohol Dehydrogenase/chemistry ; Alcohol Dehydrogenase/metabolism ; Binding Sites ; Cloning, Molecular ; DNA, Fungal/metabolism ; DNA-Binding Proteins/genetics ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Pichia/genetics ; Pichia/metabolism ; Protein Binding ; Protein Domains ; Protein Stability ; Saccharomyces cerevisiae/genetics ; Transcription Factors/genetics ; Transcriptional Activation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.
Autorzy:
Warszawski S; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Borenstein Katz A; Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Lipsh R; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Khmelnitsky L; Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Ben Nissan G; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Javitt G; Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Dym O; Israel Structural Proteomics Center, Weizmann Institute of Science, Rehovot, Israel.
Unger T; Israel Structural Proteomics Center, Weizmann Institute of Science, Rehovot, Israel.
Knop O; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Albeck S; Israel Structural Proteomics Center, Weizmann Institute of Science, Rehovot, Israel.
Diskin R; Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Fass D; Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Sharon M; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Fleishman SJ; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2019 Aug 23; Vol. 15 (8), pp. e1007207. Date of Electronic Publication: 2019 Aug 23 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibody Affinity*/genetics
Drug Design*
Immunoglobulin Variable Region/*genetics
Protein Engineering/*methods
Animals ; Computational Biology ; HEK293 Cells ; Humans ; Immunoglobulin Fragments/chemistry ; Immunoglobulin Fragments/genetics ; Immunoglobulin Heavy Chains/chemistry ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Light Chains/chemistry ; Immunoglobulin Light Chains/genetics ; Immunoglobulin Variable Region/chemistry ; Models, Molecular ; Mutagenesis, Site-Directed ; Mutation ; Oxidoreductases Acting on Sulfur Group Donors/antagonists & inhibitors ; Oxidoreductases Acting on Sulfur Group Donors/immunology ; Peptide Library ; Protein Engineering/statistics & numerical data ; Protein Stability ; Software ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Vascular Endothelial Growth Factor A/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Protein Engineering of Dual-Cys Cyanobacteriochrome AM1_1186g2 for Biliverdin Incorporation and Far-Red/Blue Reversible Photoconversion.
Autorzy:
Kuwasaki Y; Graduate School of Arts and Sciences, University of Tokyo, Komaba, Meguro, Tokyo 153-8902, Japan. .
Miyake K; Graduate School of Science and Technology, Shizuoka University, Ohya, Suruga-ku, Shizuoka 422-8529, Japan. .
Fushimi K; Graduate School of Science and Technology, Shizuoka University, Ohya, Suruga-ku, Shizuoka 422-8529, Japan. .; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan. .
Takeda Y; Graduate School of Science and Technology, Shizuoka University, Ohya, Suruga-ku, Shizuoka 422-8529, Japan. .
Ueda Y; Graduate School of Arts and Sciences, University of Tokyo, Komaba, Meguro, Tokyo 153-8902, Japan. .; Japan Agency for Medical Research and Development-PRIME, Tokyo 100-0004, Japan. .
Nakajima T; Graduate School of Arts and Sciences, University of Tokyo, Komaba, Meguro, Tokyo 153-8902, Japan. .
Ikeuchi M; Graduate School of Arts and Sciences, University of Tokyo, Komaba, Meguro, Tokyo 153-8902, Japan. .; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan. .
Sato M; Graduate School of Arts and Sciences, University of Tokyo, Komaba, Meguro, Tokyo 153-8902, Japan. .; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan. .
Narikawa R; Graduate School of Science and Technology, Shizuoka University, Ohya, Suruga-ku, Shizuoka 422-8529, Japan. .; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan. .; Green Biology Research Division, Research Institute of Green Science and Technology, Shizuoka University, Ohya, Suruga-ku, Shizuoka 422-8529, Japan. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Jun 15; Vol. 20 (12). Date of Electronic Publication: 2019 Jun 15.
Typ publikacji:
Journal Article
MeSH Terms:
Light*
Protein Engineering*
Biliverdine/*chemistry
Phytochrome/*chemistry
Phytochrome/*metabolism
Amino Acid Sequence ; Biliverdine/metabolism ; Cyanobacteria/genetics ; Cyanobacteria/metabolism ; Molecular Structure ; Photoreceptors, Microbial/genetics ; Photoreceptors, Microbial/metabolism ; Phytochrome/genetics ; Protein Stability
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
De novo design of tunable, pH-driven conformational changes.
Autorzy:
Boyken SE; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Benhaim MA; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.
Busch F; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Jia M; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Bick MJ; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Choi H; Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147, USA.
Klima JC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Chen Z; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Graduate Program in Biological Physics, Structure, and Design, University of Washington, Seattle, WA, USA.
Walkey C; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Mileant A; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.; Graduate Program in Biological Physics, Structure, and Design, University of Washington, Seattle, WA, USA.
Sahasrabuddhe A; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Wei KY; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Bioengineering, University of California, Berkeley, CA 94720, USA.
Hodge EA; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.
Byron S; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Quijano-Rubio A; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Sankaran B; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720.
King NP; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Lippincott-Schwartz J; Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147, USA.
Wysocki VH; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Lee KK; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.; Graduate Program in Biological Physics, Structure, and Design, University of Washington, Seattle, WA, USA.
Baker D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. .; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2019 May 17; Vol. 364 (6441), pp. 658-664.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Conformation*
Protein Multimerization*
Protein Engineering/*methods
Hydrogen-Ion Concentration ; Protein Stability
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Surface patches on recombinant erythropoietin predict protein solubility: engineering proteins to minimise aggregation.
Autorzy:
Carballo-Amador MA; Facultad de Ciencias, Universidad Autónoma de Baja California, Km. 103 Carretera Tijuana-Ensenada, Pedregal Playitas, 22860, Ensenada, Baja California, Mexico.
McKenzie EA; School of Chemistry, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.
Dickson AJ; Faculty of Science and Engineering, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.
Warwicker J; School of Chemistry, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK. .
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Źródło:
BMC biotechnology [BMC Biotechnol] 2019 May 09; Vol. 19 (1), pp. 26. Date of Electronic Publication: 2019 May 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Erythropoietin/*genetics
Protein Aggregation, Pathological/*genetics
Protein Engineering/*methods
Recombinant Proteins/*genetics
Erythropoietin/chemistry ; Erythropoietin/metabolism ; Humans ; Models, Molecular ; Mutation ; Protein Aggregation, Pathological/metabolism ; Protein Conformation ; Protein Stability ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Surface Properties
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Catching a SPY: Using the SpyCatcher-SpyTag and Related Systems for Labeling and Localizing Bacterial Proteins.
Autorzy:
Hatlem D; Bacterial Cell Surface Group, Section for Evolution and Genetics, Department of Biosciences, University of Oslo, 0316 Oslo, Norway. .
Trunk T; Bacterial Cell Surface Group, Section for Evolution and Genetics, Department of Biosciences, University of Oslo, 0316 Oslo, Norway. .
Linke D; Bacterial Cell Surface Group, Section for Evolution and Genetics, Department of Biosciences, University of Oslo, 0316 Oslo, Norway. .
Leo JC; Bacterial Cell Surface Group, Section for Evolution and Genetics, Department of Biosciences, University of Oslo, 0316 Oslo, Norway. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Apr 30; Vol. 20 (9). Date of Electronic Publication: 2019 Apr 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Bacterial Toxins/*chemistry
Protein Engineering/*methods
Bacterial Toxins/genetics ; Bacterial Toxins/metabolism ; Nanoparticles/chemistry ; Protein Stability ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Streptococcus pyogenes/chemistry ; Streptococcus pyogenes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Computer aided protein engineering to enhance the thermo-stability of CXCR1- T4 lysozyme complex.
Autorzy:
Wang Y; Complex Systems Division, Beijing Computational Science Research Center, Beijing, 100193, China.
Park JH; Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul, 03722, South Korea.
Lupala CS; Complex Systems Division, Beijing Computational Science Research Center, Beijing, 100193, China.
Yun JH; Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul, 03722, South Korea.
Jin Z; Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul, 03722, South Korea.
Huang L; Complex Systems Division, Beijing Computational Science Research Center, Beijing, 100193, China.
Li X; Complex Systems Division, Beijing Computational Science Research Center, Beijing, 100193, China.; Department of Engineering Physics, Tsinghua University, Beijing, 100084, China.
Tang L; Complex Systems Division, Beijing Computational Science Research Center, Beijing, 100193, China.; Department of Physics and Institute of Computational and Theoretical Studies, Hong Kong Baptist University, Hong Kong, China.
Lee W; Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul, 03722, South Korea. .
Liu H; Complex Systems Division, Beijing Computational Science Research Center, Beijing, 100193, China. .
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Źródło:
Scientific reports [Sci Rep] 2019 Mar 29; Vol. 9 (1), pp. 5317. Date of Electronic Publication: 2019 Mar 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Molecular Docking Simulation*
Molecular Dynamics Simulation*
Protein Engineering*
Muramidase/*chemistry
Muramidase/*metabolism
Receptors, Interleukin-8A/*chemistry
Receptors, Interleukin-8A/*metabolism
Amino Acid Sequence ; Binding Sites ; Muramidase/genetics ; Mutation ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Stability ; Receptors, Interleukin-8A/genetics ; Structure-Activity Relationship ; Thermodynamics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Packing of apolar side chains enables accurate design of highly stable membrane proteins.
Autorzy:
Mravic M; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Thomaston JL; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Tucker M; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Solomon PE; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Liu L; State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China. .; DLX Scientific, Lawrence, KS 66049, USA.
DeGrado WF; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2019 Mar 29; Vol. 363 (6434), pp. 1418-1423.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Models, Molecular*
Molecular Dynamics Simulation*
Protein Folding*
Calcium-Binding Proteins/*chemistry
Membrane Proteins/*chemistry
Protein Engineering/*methods
Amino Acid Sequence ; Hydrophobic and Hydrophilic Interactions ; Protein Stability ; Protein Structure, Secondary
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 497

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