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Wyszukujesz frazę ""Protein Subunits"" wg kryterium: Temat


Tytuł:
Phase separation promotes a highly active oligomeric scaffold of the MLL1 core complex for regulation of histone H3K4 methylation.
Autorzy:
Namitz KEW; Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York, USA.
Showalter SA; Department of Chemistry, Penn State University, University Park, Pennsylvania, USA.
Cosgrove MS; Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York, USA. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Oct; Vol. 299 (10), pp. 105204. Date of Electronic Publication: 2023 Sep 01.
Typ publikacji:
Journal Article
MeSH Terms:
Histones*/metabolism
Myeloid-Lymphoid Leukemia Protein*/metabolism
Protein Subunits*/chemistry
Protein Subunits*/metabolism
Models, Molecular*
Humans ; Methylation ; Phase Separation ; Protein Structure, Quaternary ; Thermodynamics ; Enzyme Activation
Czasopismo naukowe
Tytuł:
Beta-subunit-eliminated eHAP expression (BeHAPe) cells reveal subunit regulation of the cardiac voltage-gated sodium channel.
Autorzy:
Minard AY; Department of Molecular Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, Iowa, United States.
Clark CJ; Department of Molecular Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, Iowa, United States.
Ahern CA; Department of Molecular Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, Iowa, United States. Electronic address: .
Piper RC; Department of Molecular Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, Iowa, United States. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Sep; Vol. 299 (9), pp. 105132. Date of Electronic Publication: 2023 Aug 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
NAV1.5 Voltage-Gated Sodium Channel*/chemistry
NAV1.5 Voltage-Gated Sodium Channel*/metabolism
Protein Subunits*/chemistry
Protein Subunits*/deficiency
Protein Subunits*/genetics
Protein Subunits*/metabolism
Voltage-Gated Sodium Channel beta Subunits*/chemistry
Voltage-Gated Sodium Channel beta Subunits*/deficiency
Voltage-Gated Sodium Channel beta Subunits*/genetics
Voltage-Gated Sodium Channel beta Subunits*/metabolism
Humans ; Action Potentials ; Cell Line ; Intracellular Signaling Peptides and Proteins/metabolism ; Phosphoproteins/metabolism ; Mutation
Czasopismo naukowe
Tytuł:
Protomers of the green and cyan fluorescent protein chromophores investigated using action spectroscopy.
Autorzy:
Ashworth EK; School of Chemistry, Norwich Research Park, University of East Anglia, Norwich NR4 7TJ, UK. .
Dezalay J; Department of Physics, Stockholm University, SE-10691 Stockholm, Sweden.
Ryan CRM; Department of Chemistry, University of Waterloo, Waterloo N2L 3G1, Canada.
Ieritano C; Department of Chemistry, University of Waterloo, Waterloo N2L 3G1, Canada.
Hopkins WS; Department of Chemistry, University of Waterloo, Waterloo N2L 3G1, Canada.
Chambrier I; School of Chemistry, Norwich Research Park, University of East Anglia, Norwich NR4 7TJ, UK. .
Cammidge AN; School of Chemistry, Norwich Research Park, University of East Anglia, Norwich NR4 7TJ, UK. .
Stockett MH; Department of Physics, Stockholm University, SE-10691 Stockholm, Sweden.
Noble JA; Aix-Marseille University, CNRS, PIIM, Marseille, France.
Bull JN; School of Chemistry, Norwich Research Park, University of East Anglia, Norwich NR4 7TJ, UK. .
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Źródło:
Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2023 Aug 02; Vol. 25 (30), pp. 20405-20413. Date of Electronic Publication: 2023 Aug 02.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Subunits*/chemistry
Spectrum Analysis ; Green Fluorescent Proteins/chemistry ; Ions/chemistry
Czasopismo naukowe
Tytuł:
Reconstitution of the phosphodiesterase 6 maturation process important for photoreceptor cell function.
Autorzy:
Singh S; Department of Molecular Physiology and Biophysics, The University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Srivastava D; Department of Molecular Physiology and Biophysics, The University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Boyd K; Department of Molecular Physiology and Biophysics, The University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Artemyev NO; Department of Molecular Physiology and Biophysics, The University of Iowa Carver College of Medicine, Iowa City, Iowa, USA; Department of Ophthalmology and Visual Sciences, The University of Iowa Carver College of Medicine, Iowa City, Iowa, USA. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2024 Jan; Vol. 300 (1), pp. 105576. Date of Electronic Publication: 2023 Dec 16.
Typ publikacji:
Journal Article
MeSH Terms:
Cyclic Nucleotide Phosphodiesterases, Type 6*/chemistry
Cyclic Nucleotide Phosphodiesterases, Type 6*/deficiency
Cyclic Nucleotide Phosphodiesterases, Type 6*/genetics
Cyclic Nucleotide Phosphodiesterases, Type 6*/metabolism
Retinal Cone Photoreceptor Cells*/chemistry
Retinal Cone Photoreceptor Cells*/metabolism
Animals ; Humans ; Mice ; Adaptor Proteins, Signal Transducing/metabolism ; Blindness/genetics ; Cell Line ; HSP90 Heat-Shock Proteins/metabolism ; Mutation ; Protein Multimerization ; Protein Subunits/chemistry ; Protein Subunits/deficiency ; Protein Subunits/genetics ; Protein Subunits/metabolism
Czasopismo naukowe
Tytuł:
hERG1 channel subunit composition mediates proton inhibition of rapid delayed rectifier potassium current (I Kr ) in cardiomyocytes derived from hiPSCs.
Autorzy:
Ukachukwu CU; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Jimenez-Vazquez EN; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Jain A; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Jones DK; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA; Department of Internal Medicine, University of Michigan Medical School. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Feb; Vol. 299 (2), pp. 102778. Date of Electronic Publication: 2022 Dec 08.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
ERG1 Potassium Channel*/chemistry
ERG1 Potassium Channel*/genetics
ERG1 Potassium Channel*/metabolism
Induced Pluripotent Stem Cells*/cytology
Myocytes, Cardiac*/metabolism
Potassium*/metabolism
Protons*
Electric Conductivity*
Protein Subunits*/chemistry
Protein Subunits*/genetics
Protein Subunits*/metabolism
Humans ; Acidosis/metabolism ; RNA, Messenger/metabolism ; Down-Regulation ; Extracellular Space
Czasopismo naukowe
Tytuł:
Fourth dose of microneedle array patch of SARS-CoV-2 S1 protein subunit vaccine elicits robust long-lasting humoral responses in mice.
Autorzy:
Kim E; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Shin J; Medical Business Division, Raphas Co., Ltd., Seoul, Republic of Korea.
Ferrari A; Molecular Virology Unit, Microbiology and Virology Department, IRCCS Policlinico San Matteo, Pavia, Italy.
Huang S; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
An E; Medical Business Division, Raphas Co., Ltd., Seoul, Republic of Korea.
Han D; Medical Business Division, Raphas Co., Ltd., Seoul, Republic of Korea.
Khan MS; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA.
Kenniston TW; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Cassaniti I; Molecular Virology Unit, Microbiology and Virology Department, IRCCS Policlinico San Matteo, Pavia, Italy.
Baldanti F; Molecular Virology Unit, Microbiology and Virology Department, IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Jeong D; Medical Business Division, Raphas Co., Ltd., Seoul, Republic of Korea.
Gambotto A; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; UPMC Hillman Cancer Center, Pittsburgh, PA, USA. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Mar 10; Vol. 129, pp. 111569. Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19 Vaccines*
COVID-19*/prevention & control
Animals ; Humans ; Mice ; Protein Subunits ; SARS-CoV-2 ; Protein Subunit Vaccines ; Pandemics ; Antibodies, Neutralizing ; Immunoglobulin G ; Antibodies, Viral
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Characterization of the Zinc Uptake Repressor (Zur) from Acinetobacter baumannii .
Autorzy:
Kim M; Department of Chemistry, Indiana University, Bloomington, Indiana 47405-7102, United States.; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana 47405, United States.
Le MT; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana 47405, United States.
Fan L; Basic Science Program, Frederick National Laboratory for Cancer Research, SAXS Core Facility of the National Cancer Institute, Frederick, Maryland 21702, United States.
Campbell C; Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan 48201-2417, United States.
Sen S; Department of Chemistry, Indiana University, Bloomington, Indiana 47405-7102, United States.
Capdevila DA; Fundación Instituto Leloir, Instituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA-CONICET), C1405 BWE Buenos Aires, Argentina.
Stemmler TL; Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan 48201-2417, United States.
Giedroc DP; Department of Chemistry, Indiana University, Bloomington, Indiana 47405-7102, United States.; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana 47405, United States.
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Źródło:
Biochemistry [Biochemistry] 2024 Mar 05; Vol. 63 (5), pp. 660-670. Date of Electronic Publication: 2024 Feb 22.
Typ publikacji:
Journal Article
MeSH Terms:
Acinetobacter baumannii*/genetics
Acinetobacter baumannii*/metabolism
Isoquinolines*
Sulfonamides*
Bacterial Proteins/chemistry ; Binding Sites ; Cadmium ; Protein Subunits ; Scattering, Small Angle ; Zinc/metabolism ; X-Ray Diffraction ; Repressor Proteins/metabolism ; Metals ; DNA/metabolism
Czasopismo naukowe
Tytuł:
Spectral Tuning and Excitation-Energy Transfer by Unique Carotenoids in Diatom Light-Harvesting Antenna.
Autorzy:
Fujimoto KJ; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Furocho, Chikusa, Nagoya 464-8601, Japan.; Department of Chemistry, Graduate School of Science, Nagoya University, Furocho, Chikusa, Nagoya 464-8601, Japan.
Seki T; Department of Chemistry, Graduate School of Science, Nagoya University, Furocho, Chikusa, Nagoya 464-8601, Japan.
Minoda T; Department of Chemistry, Graduate School of Science, Nagoya University, Furocho, Chikusa, Nagoya 464-8601, Japan.
Yanai T; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Furocho, Chikusa, Nagoya 464-8601, Japan.; Department of Chemistry, Graduate School of Science, Nagoya University, Furocho, Chikusa, Nagoya 464-8601, Japan.
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Źródło:
Journal of the American Chemical Society [J Am Chem Soc] 2024 Feb 14; Vol. 146 (6), pp. 3984-3991. Date of Electronic Publication: 2024 Jan 18.
Typ publikacji:
Journal Article
MeSH Terms:
Carotenoids*/chemistry
Diatoms*/chemistry
Xanthophylls*
Chlorophyll A ; Cryoelectron Microscopy ; Protein Subunits/metabolism ; Chlorophyll/chemistry ; Light-Harvesting Protein Complexes/chemistry ; Energy Transfer ; Chlorophyll Binding Proteins/chemistry ; Chlorophyll Binding Proteins/metabolism
Czasopismo naukowe
Tytuł:
Inhibition of ferroptosis by POLE2 in gastric cancer cells involves the activation of NRF2/GPX4 pathway.
Autorzy:
Jian H; Department of Gastrointestinal Surgery, Affiliated Hospital of Jianghan University, Wuhan, Hubei, China.
Chen ZQ; Department of Gastrointestinal Surgery, Affiliated Hospital of Jianghan University, Wuhan, Hubei, China.
Du H; Department of Gastrointestinal Surgery, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang, Hubei, China.
Liao T; Department of Gastroenterology, Affiliated Hospital of Jianghan University, Wuhan, Hubei, China.
Sun YC; Department of Oncology, Affiliated Hospital of Jianghan University, Wuhan, Hubei, China.
Ke D; Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Yu Y; Department of Gastrointestinal Surgery, Affiliated Hospital of Jianghan University, Wuhan, Hubei, China.
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Źródło:
Journal of cellular and molecular medicine [J Cell Mol Med] 2024 Jan; Vol. 28 (1), pp. e17983. Date of Electronic Publication: 2023 Dec 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ferroptosis*
Stomach Neoplasms*
Humans ; Lentivirus ; NF-E2-Related Factor 2 ; Nucleotidyltransferases ; Protein Subunits
Czasopismo naukowe
Tytuł:
Distinct oligomerization and NADPH binding modes observed between L. donovani and human quinone oxidoreductases.
Autorzy:
Vishwakarma C; Biochemistry and Structural Biology Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.
Ansari A; Biochemistry and Structural Biology Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India.
Pratap JV; Biochemistry and Structural Biology Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Jan 01; Vol. 690, pp. 149096. Date of Electronic Publication: 2023 Nov 10.
Typ publikacji:
Journal Article
MeSH Terms:
NAD(P)H Dehydrogenase (Quinone)*/metabolism
Quinone Reductases*/chemistry
Quinone Reductases*/metabolism
Humans ; NADP/metabolism ; Protein Subunits ; Quinones ; Arginine ; Binding Sites ; Crystallography, X-Ray
Czasopismo naukowe
Tytuł:
Efficient degradation of soybean protein B 3 subunit in soy sauce by ultrasound-assisted prolyl endopeptidase and its primary mechanism.
Autorzy:
Zhang Z; School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China.
Shan P; School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China.
Zhang ZH; School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China.
He R; School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China.
Xing L; Honworld Group Limited, 299 Zhongxing Avenue, Huzhou 313000, China.
Liu J; Honworld Group Limited, 299 Zhongxing Avenue, Huzhou 313000, China.
He D; Honworld Group Limited, 299 Zhongxing Avenue, Huzhou 313000, China.
Ma H; School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China.
Wang Z; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China. Electronic address: .
Gao X; School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China. Electronic address: .
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Źródło:
Food chemistry [Food Chem] 2023 Dec 15; Vol. 429, pp. 136972. Date of Electronic Publication: 2023 Jul 22.
Typ publikacji:
Journal Article
MeSH Terms:
Soy Foods*
Soybean Proteins/chemistry ; Soybean Proteins/metabolism ; Prolyl Oligopeptidases/metabolism ; Molecular Weight ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Fermentation ; Protein Structure, Secondary ; Sonication
Czasopismo naukowe
Tytuł:
Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
Autorzy:
Sun C; Vollum Institute, Oregon Health and Science University, Portland, OR, USA.
Zhu H; Vollum Institute, Oregon Health and Science University, Portland, OR, USA.; Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China.
Clark S; Vollum Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, USA.
Gouaux E; Vollum Institute, Oregon Health and Science University, Portland, OR, USA. .; Howard Hughes Medical Institute, Oregon Health and Science University, Portland, OR, USA. .
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Źródło:
Nature [Nature] 2023 Oct; Vol. 622 (7981), pp. 195-201. Date of Electronic Publication: 2023 Sep 20.
Typ publikacji:
Journal Article
MeSH Terms:
Cryoelectron Microscopy*
gamma-Aminobutyric Acid*/metabolism
Neurosteroids*/metabolism
Neurosteroids*/pharmacology
Receptors, GABA-A*/chemistry
Receptors, GABA-A*/drug effects
Receptors, GABA-A*/metabolism
Receptors, GABA-A*/ultrastructure
Animals ; Mice ; Binding Sites/drug effects ; Depression, Postpartum/drug therapy ; Flurazepam/pharmacology ; Hypnotics and Sedatives/pharmacology ; Ion Channel Gating/drug effects ; Photobleaching ; Pregnanolone/pharmacology ; Protein Conformation/drug effects ; Protein Subunits/chemistry ; Protein Subunits/drug effects ; Protein Subunits/metabolism ; Sleep Initiation and Maintenance Disorders/drug therapy ; Zolpidem/pharmacology
Czasopismo naukowe
Tytuł:
Differential regulation of tetramerization of the AMPA receptor glutamate-gated ion channel by auxiliary subunits.
Autorzy:
Certain N; Graduate Program in Molecular and Cellular Pharmacology, Stony Brook University, Stony Brook, New York, USA.
Gan Q; Graduate Program in Neuroscience, Stony Brook University, Stony Brook, New York, USA.
Bennett J; Department of Neurobiology & Behavior, Stony Brook University, Stony Brook, New York, USA.
Hsieh H; Department of Surgery, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA; Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York, USA.
Wollmuth LP; Department of Neurobiology & Behavior, Stony Brook University, Stony Brook, New York, USA; Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York, USA; Department of Biochemistry & Cell Biology, Stony Brook University, Stony Brook, New York, USA. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Oct; Vol. 299 (10), pp. 105227. Date of Electronic Publication: 2023 Sep 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Glutamic Acid*/metabolism
Receptors, AMPA*/chemistry
Receptors, AMPA*/genetics
Protein Multimerization*
Neurons/metabolism ; Protein Domains ; Signal Transduction ; Protein Subunits/chemistry ; Protein Subunits/genetics ; HEK293 Cells ; Humans
Czasopismo naukowe
Tytuł:
Effect of high-molecular-weight glutenin subunits silencing on dough aggregation characteristics.
Autorzy:
Wang Q; The National Engineering Laboratory for Wheat & Corn Further Processing, Henan University of Technology, Zhengzhou 450001, China; School of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China.
Wang Z; School of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China.
Wang Z; School of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China.
Duan Y; School of International Education, Henan University of Technology, Zhengzhou 450001, China.
Guo H; School of International Education, Henan University of Technology, Zhengzhou 450001, China.
Liang Y; School of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China.
Zhang X; School of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China.
Zhang Y; Institute of Cereal and Oil Crops, Hebei Academy of Agriculture and Forestry Sciences, Laboratory of Crop Genetics and Breeding of Hebei, Shijiazhuang 050035, China. Electronic address: .
Wang J; School of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China. Electronic address: .
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Źródło:
Food chemistry [Food Chem] 2024 May 30; Vol. 441, pp. 138371. Date of Electronic Publication: 2024 Jan 08.
Typ publikacji:
Journal Article
MeSH Terms:
Gliadin*/metabolism
Glutens*/chemistry
Molecular Weight ; Triticum/chemistry ; Flour ; Protein Subunits/chemistry
Czasopismo naukowe
Tytuł:
Structure of the nutrient-sensing hub GATOR2.
Autorzy:
Valenstein ML; Whitehead Institute for Biomedical Research, Cambridge, MA, USA. .; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. .
Rogala KB; Whitehead Institute for Biomedical Research, Cambridge, MA, USA. .; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA. .; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. .; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA. .; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA. .
Lalgudi PV; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Brignole EJ; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; MIT.nano, Massachusetts Institute of Technology, Cambridge, MA, USA.
Gu X; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Saxton RA; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Chantranupong L; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Kolibius J; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.
Quast JP; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.
Sabatini DM
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Źródło:
Nature [Nature] 2022 Jul; Vol. 607 (7919), pp. 610-616. Date of Electronic Publication: 2022 Jul 13.
Typ publikacji:
Journal Article
MeSH Terms:
Amino Acids*/metabolism
Cryoelectron Microscopy*
Multiprotein Complexes*/chemistry
Multiprotein Complexes*/metabolism
Multiprotein Complexes*/ultrastructure
Nutrients*/metabolism
Protein Subunits*/chemistry
Protein Subunits*/metabolism
Humans ; Arginine ; Carrier Proteins ; Leucine ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Protein Domains ; Proteins
Czasopismo naukowe
Tytuł:
Safety and immunogenicity of SCB-2019, an adjuvanted, recombinant SARS-CoV-2 trimeric S-protein subunit COVID-19 vaccine in healthy 12-17 year-old adolescents.
Autorzy:
Lopez P; Centro de Estudios en Infectología Pediátrica, Universidad Del Valle Clínica Imbanaco, Cali, Colombia.
Bravo L; College of Medicine, University of the Philippines Manila, Ermita, The Philippines.
Buntinx E; Anima Research Center, Alken, Belgium.
Borja-Tabora C; Asian Hospital and Medical Center, Muntinlupa, Philippines.
Velasquez H; Center of Attention in Medical Research (CAIMED), Bogotá, Colombia.
Rodriquez EJ; Center of Attention in Medical Research (CAIMED), Bogotá, Colombia.
Rodriguez CA; Policlínico Social del Norte, Bogotá, Colombia.
Carlos J; University of the East Ramon Magsaysay Memorial Medical Center, Quezon City, The Philippines.
Montellano MEB; Far Eastern University Hospital - Nicanor Reyes Medical Foundation, Quezon City, The Philippines.
Alberto ER; Tropical Disease Foundation-HIMC, Cavite City, The Philippines.
Salvani-Bautista M; University of the East Ramon Magsaysay Memorial Medical Center, Quezon City, The Philippines.
Huang Y; Clover Biopharmaceuticals, Boston, MA, USA.
Hu B; Clover Biopharmaceuticals, Boston, MA, USA.
Li P; Clover Biopharmaceuticals, Boston, MA, USA.
Han HH; Clover Biopharmaceuticals, Boston, MA, USA.
Baccarini C; Clover Biopharmaceuticals, Boston, MA, USA.
Smolenov I; Clover Biopharmaceuticals, Boston, MA, USA.
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Źródło:
Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2023 Dec 31; Vol. 19 (1), pp. 2206359. Date of Electronic Publication: 2023 May 25.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19*/prevention & control
COVID-19 Vaccines*/adverse effects
Adolescent ; Adult ; Child ; Humans ; Young Adult ; Adjuvants, Immunologic/adverse effects ; Antibodies, Neutralizing ; Antibodies, Viral ; Double-Blind Method ; Immunogenicity, Vaccine ; Protein Subunits ; SARS-CoV-2
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2.
Autorzy:
Zhu H; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Tonelli F; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.
Turk M; Cryo-EM and Tomography Center, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Prescott A; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Alessi DR; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.
Sun J; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Dec 22; Vol. 382 (6677), pp. 1404-1411. Date of Electronic Publication: 2023 Dec 21.
Typ publikacji:
Journal Article
MeSH Terms:
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/antagonists & inhibitors
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/chemistry
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/genetics
Parkinson Disease*/drug therapy
Parkinson Disease*/genetics
rab GTP-Binding Proteins*/chemistry
Humans ; Antiparkinson Agents/chemistry ; Antiparkinson Agents/pharmacology ; Catalytic Domain ; Cryoelectron Microscopy ; Drug Design ; Gain of Function Mutation ; Protein Subunits/chemistry ; Protein Multimerization ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology
SCR Disease Name:
Parkinson Disease 16
Czasopismo naukowe
Tytuł:
A booster of Delta-Omicron RBD-dimer protein subunit vaccine augments sera neutralization of Omicron sub-variants BA.1/BA.2/BA.2.12.1/BA.4/BA.5.
Autorzy:
Duan M; School of Life Sciences, Yunnan University, Kunming, People's Republic of China.
Duan H; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, People's Republic of China.
An Y; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, People's Republic of China.
Zheng T; Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Wan S; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
Wang H; Beijing Institute of Biological Products Company Limited, Beijing, People's Republic of China.
Zhao X; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
Dai L; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, People's Republic of China.; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
Xu K; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, People's Republic of China.
Gao GF; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, People's Republic of China.; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, People's Republic of China.
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Źródło:
Emerging microbes & infections [Emerg Microbes Infect] 2023 Dec; Vol. 12 (1), pp. e2179357.
Typ publikacji:
Letter
MeSH Terms:
Carrier Proteins*
COVID-19*/prevention & control
Animals ; Humans ; Mice ; COVID-19 Vaccines ; SARS-CoV-2 ; Protein Subunits ; Antibodies, Neutralizing ; Antibodies, Viral
SCR Organism:
SARS-CoV-2 variants
Opinia redakcyjna
Tytuł:
Multistep conformational changes leading to the gate opening of light-driven sodium pump rhodopsin.
Autorzy:
Sato Y; Graduate School of Life Science, Hokkaido University, Sapporo, Japan.
Hashimoto T; Graduate School of Life Science, Hokkaido University, Sapporo, Japan.
Kato K; Research Institute for Interdisciplinary Science, Okayama University, Okayama, Japan.
Okamura A; Graduate School of Life Science, Hokkaido University, Sapporo, Japan.
Hasegawa K; Graduate School of Life Science, Hokkaido University, Sapporo, Japan.
Shinone T; Graduate School of Life Science, Hokkaido University, Sapporo, Japan.
Tanaka Y; Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
Tanaka Y; Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara, Japan.
Tsukazaki T; Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara, Japan.
Tsukamoto T; Graduate School of Life Science, Hokkaido University, Sapporo, Japan; Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.
Demura M; Graduate School of Life Science, Hokkaido University, Sapporo, Japan; Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.
Yao M; Graduate School of Life Science, Hokkaido University, Sapporo, Japan; Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.
Kikukawa T; Graduate School of Life Science, Hokkaido University, Sapporo, Japan; Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Dec; Vol. 299 (12), pp. 105393. Date of Electronic Publication: 2023 Oct 27.
Typ publikacji:
Journal Article
MeSH Terms:
Rhodopsin*/chemistry
Rhodopsin*/metabolism
Cell Membrane/metabolism ; Ion Transport ; Ions/metabolism ; Protein Subunits/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism ; Animals
Czasopismo naukowe
Tytuł:
G Protein Subunit Beta 3 (GNB3) Variant Is Associated with Biochemical Changes in Brazilian Patients with Hypertension.
Autorzy:
Agostini LDC; Universidade Federal de Ouro Preto (UFOP), Ouro Preto , MG - Brasil.
Silva NNT; Universidade Federal de Ouro Preto (UFOP) - Departamento de Análises Clínicas (DEACL), Ouro Preto , MG - Brasil.
Lopes ACF; Universidade Federal de Ouro Preto (UFOP) - Departamento de Análises Clínicas (DEACL), Ouro Preto , MG - Brasil.
Melo AS; Universidade Federal de Ouro Preto (UFOP), Ouro Preto , MG - Brasil.
Bicalho LSM; Universidade Federal de Ouro Preto (UFOP), Ouro Preto , MG - Brasil.
Almeida TC; Butantan Institute , São Paulo , SP - Brasil.
Belo VA; Universidade Federal de Ouro Preto - Programa de Pós-Graduação em Ciências Farmacêuticas ( CiPharma ) - Departamento de Farmácia ( DEFAR ), Ouro Preto , MG - Brasil.
Coura-Vital W; Universidade Federal de Ouro Preto - Programa de Pós-Graduação em Ciências Farmacêuticas ( CiPharma ) - Departamento de Análises Clínicas ( DEACL ), Ouro Preto , MG - Brasil.
Teixeira LFM; Universidade Federal de Ouro Preto (UFOP) - Departamento de Análises Clínicas (DEACL), Ouro Preto , MG - Brasil.
Lima AA; Universidade Federal de Ouro Preto - Programa de Pós-Graduação em Ciências Farmacêuticas ( CiPharma ) - Departamento de Análises Clínicas ( DEACL ), Ouro Preto , MG - Brasil.
Silva GND; Universidade Federal de Ouro Preto - Programa de Pós-Graduação em Ciências Farmacêuticas ( CiPharma ) - Departamento de Análises Clínicas ( DEACL ), Ouro Preto , MG - Brasil.
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Transliterated Title:
Variante da Subunidade Beta 3 da Proteína G ( GNB3 ) Está Associada a Alterações Bioquímicas em Pacientes Brasileiros com Hipertensão.
Źródło:
Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2023 Dec; Vol. 120 (12), pp. e20230396.
Typ publikacji:
Journal Article
MeSH Terms:
Hypertension*/genetics
Heterotrimeric GTP-Binding Proteins*/genetics
Humans ; Alleles ; Blood Pressure/genetics ; Brazil ; Genotype ; Protein Subunits/genetics
Czasopismo naukowe

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