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Wyszukujesz frazę ""Protein Tyrosine Phosphatase, Non-Receptor Type 1"" wg kryterium: Temat


Tytuł :
Natural α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors: A Source of Scaffold Molecules for Synthesis of New Multitarget Antidiabetic Drugs.
Autorzy :
Genovese M; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, 50139 Florence, Italy.
Nesi I; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, 50139 Florence, Italy.
Caselli A; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, 50139 Florence, Italy.
Paoli P; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, 50139 Florence, Italy.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Aug 09; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Enzyme Inhibitors/*chemistry
Hypoglycemic Agents/*chemistry
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*antagonists & inhibitors
alpha-Glucosidases/*drug effects
Diabetes Mellitus, Type 2/drug therapy ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/therapeutic use ; Glycoside Hydrolase Inhibitors/chemical synthesis ; Glycoside Hydrolase Inhibitors/chemistry ; Glycoside Hydrolase Inhibitors/therapeutic use ; Humans ; Hypoglycemic Agents/chemical synthesis ; Hypoglycemic Agents/therapeutic use ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/chemistry ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/genetics ; alpha-Glucosidases/chemistry ; alpha-Glucosidases/genetics
Czasopismo naukowe
Tytuł :
Indole- and Pyrazole-Glycyrrhetinic Acid Derivatives as PTP1B Inhibitors: Synthesis, In Vitro and In Silico Studies.
Autorzy :
De-la-Cruz-Martínez L; Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Xochimilco (UAM-X), Ciudad de México 04960, Mexico.; Maestría en Ciencias Farmacéuticas, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Xochimilco (UAM-X), Ciudad de México 04960, Mexico.
Duran-Becerra C; Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Xochimilco (UAM-X), Ciudad de México 04960, Mexico.
González-Andrade M; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico.
Páez-Franco JC; Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14000, Mexico.
Germán-Acacio JM; Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14000, Mexico.
Espinosa-Chávez J; Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58030, Mexico.
Torres-Valencia JM; Área Académica de Química, Universidad Autónoma del Estado de Hidalgo, Pachuca 42184, Mexico.
Pérez-Villanueva J; Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Xochimilco (UAM-X), Ciudad de México 04960, Mexico.
Palacios-Espinosa JF; Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Xochimilco (UAM-X), Ciudad de México 04960, Mexico.
Soria-Arteche O; Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Xochimilco (UAM-X), Ciudad de México 04960, Mexico.
Cortés-Benítez F; Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Xochimilco (UAM-X), Ciudad de México 04960, Mexico.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jul 20; Vol. 26 (14). Date of Electronic Publication: 2021 Jul 20.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Inhibitors*/chemical synthesis
Enzyme Inhibitors*/chemistry
Glycyrrhetinic Acid*/analogs & derivatives
Glycyrrhetinic Acid*/chemical synthesis
Glycyrrhetinic Acid*/chemistry
Indoles*/chemical synthesis
Indoles*/chemistry
Molecular Docking Simulation*
Molecular Dynamics Simulation*
Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors
Protein Tyrosine Phosphatase, Non-Receptor Type 1*/chemistry
Pyrazoles*/chemical synthesis
Pyrazoles*/chemistry
Humans ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Pyrazoles as novel protein tyrosine phosphatase 1B (PTP1B) inhibitors: An in vitro and in silico study.
Autorzy :
Rocha S; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Lucas M; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Silva VLM; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Gomes PMO; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Silva AMS; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Araújo AN; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Aniceto N; Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, Portugal.
Guedes RC; Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, Portugal.
Corvo ML; Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, Portugal.
Fernandes E; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal. Electronic address: .
Freitas M; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jun 30; Vol. 181, pp. 1171-1182. Date of Electronic Publication: 2021 Apr 13.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Type 2/*drug therapy
Enzyme Inhibitors/*pharmacology
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*genetics
Pyrazoles/*pharmacology
Binding Sites/drug effects ; Computer Simulation ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Enzyme Inhibitors/chemistry ; Humans ; Insulin/chemistry ; Insulin/genetics ; Insulin/metabolism ; Insulin Resistance/genetics ; Molecular Docking Simulation ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/chemistry ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/genetics ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Assessment of Antidiabetic Activity of the Shikonin by Allosteric Inhibition of Protein-Tyrosine Phosphatase 1B (PTP1B) Using State of Art: An In Silico and In Vitro Tactics.
Autorzy :
Saeed M; Department of Biology, College of Sciences, University of Hail, Hail 81451, Saudi Arabia.
Shoaib A; Department of Clinical Pharmacy, College of Pharmacy, Jazan University, P.O. Box No. 114, Jazan 45142, Saudi Arabia.
Tasleem M; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China.
Alabdallah NM; Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, 383, Dammam 31113, Saudi Arabia.
Alam MJ; Department of Biology, College of Sciences, University of Hail, Hail 81451, Saudi Arabia.
Asmar ZE; Department of Biology, College of Sciences, University of Hail, Hail 81451, Saudi Arabia.
Jamal QMS; Department of Health Informatics, College of Public Health and Health Informatics, Qassim University, Al Bukayriyah 52571, Saudi Arabia.
Bardakci F; Department of Biology, College of Sciences, University of Hail, Hail 81451, Saudi Arabia.
Alqahtani SS; Department of Clinical Pharmacy, College of Pharmacy, Jazan University, P.O. Box No. 114, Jazan 45142, Saudi Arabia.
Ansari IA; Department of Biosciences, Integral University, Lucknow 226026, India.
Badraoui R; Department of Biology, College of Sciences, University of Hail, Hail 81451, Saudi Arabia.; Section of Histology-Cytology, Medicine Faculty of Tunis, University of Tunis El Manar, La Rabta-Tunis 1007, Tunisia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 30; Vol. 26 (13). Date of Electronic Publication: 2021 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Docking Simulation*
Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors
Protein Tyrosine Phosphatase, Non-Receptor Type 1*/chemistry
Enzyme Inhibitors/*chemistry
Hypoglycemic Agents/*chemistry
Naphthoquinones/*chemistry
Allosteric Regulation ; Humans ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
On the Inhibitability of Natural Products Isolated from Tetradium ruticarpum towards Tyrosine Phosphatase 1B (PTP1B) and α-Glucosidase (3W37): An In Vitro and In Silico Study.
Autorzy :
To DC; Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, Vietnam.; A&A Green Phoenix Group JSC, Phenikaa Research and Technology Institute (PRATI), 167 Hoang Ngan, Cau Giay District, Hanoi 11313, Vietnam.
Bui TQ; Department of Chemistry, University of Sciences, Hue University, Hue City 530000, Vietnam.
Nhung NTA; Department of Chemistry, University of Sciences, Hue University, Hue City 530000, Vietnam.
Tran QT; Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay District, Hanoi 122100, Vietnam.
Do TT; Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay District, Hanoi 122100, Vietnam.
Tran MH; Faculty of Hi-Tech Agricultural and Food Sciences, Dong A University, Da Nang City 550000, Vietnam.
Hien PP; Institute of Applied Science and Technology, Van Lang University, Ho Chi Minh City 700000, Vietnam.
Ngu TN; Department of Natural Sciences & Technology, Tay Nguyen University, Buon Ma Thuot, Dak Lak 630000, Vietnam.
Quy PT; Department of Natural Sciences & Technology, Tay Nguyen University, Buon Ma Thuot, Dak Lak 630000, Vietnam.
Nguyen TH; College of Agriculture and Forestry, Thai Nguyen University (TUAF), Quyet Thang 24119, Vietnam.
Nguyen HT; College of Agriculture and Forestry, Thai Nguyen University (TUAF), Quyet Thang 24119, Vietnam.
Nguyen TD; College of Agriculture and Forestry, Thai Nguyen University (TUAF), Quyet Thang 24119, Vietnam.; Institute of Forestry Researh and Development, TUAF, Quyet Thang 24119, Vietnam.
Nguyen PH; Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay District, Hanoi 122100, Vietnam.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 17; Vol. 26 (12). Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Journal Article
MeSH Terms :
Evodia/*metabolism
Glycoside Hydrolase Inhibitors/*chemistry
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*antagonists & inhibitors
Biological Products/chemistry ; Biological Products/pharmacology ; Enzyme Inhibitors/pharmacology ; Molecular Docking Simulation ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/drug effects ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Structure-Activity Relationship ; alpha-Glucosidases/drug effects ; alpha-Glucosidases/metabolism
Czasopismo naukowe
Tytuł :
Regulation of Phosphoinositide Levels in the Retina by Protein Tyrosine Phosphatase 1B and Growth Factor Receptor-Bound Protein 14.
Autorzy :
Rajala RVS; Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Dean McGee Eye Institute, Oklahoma City, OK 73104, USA.
McCauley A; Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Dean McGee Eye Institute, Oklahoma City, OK 73104, USA.
Rajala R; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Cardiovascular Biology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Teel K; Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Dean McGee Eye Institute, Oklahoma City, OK 73104, USA.
Rajala A; Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Dean McGee Eye Institute, Oklahoma City, OK 73104, USA.
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Źródło :
Biomolecules [Biomolecules] 2021 Apr 19; Vol. 11 (4). Date of Electronic Publication: 2021 Apr 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Phosphatidylinositols/*metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*metabolism
Retina/*metabolism
Adaptor Proteins, Signal Transducing/chemistry ; Animals ; Binding Sites ; Mice ; Protein Binding ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/chemistry
Czasopismo naukowe
Tytuł :
Protein tyrosine phosphatase 1B inhibitors from the fungus Malbranchea albolutea.
Autorzy :
Díaz-Rojas M; Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico.
Raja H; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, 27412, NC, USA.
González-Andrade M; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Rivera-Chávez J; Instituto de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Rangel-Grimaldo M; Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico.
Rivero-Cruz I; Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico.
Mata R; Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico. Electronic address: .
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Źródło :
Phytochemistry [Phytochemistry] 2021 Apr; Vol. 184, pp. 112664. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Inhibitors*/pharmacology
Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism
Fungi/metabolism ; Kinetics ; Molecular Docking Simulation ; Onygenales
SCR Organism :
Auxarthron alboluteum
Czasopismo naukowe
Tytuł :
Loop Dynamics and Enzyme Catalysis in Protein Tyrosine Phosphatases.
Autorzy :
Crean RM; Science for Life Laboratory, Department of Chemistry - BMC, Uppsala University, Box 576, S-751 23 Uppsala, Sweden.
Biler M; Science for Life Laboratory, Department of Chemistry - BMC, Uppsala University, Box 576, S-751 23 Uppsala, Sweden.
van der Kamp MW; School of Biochemistry, University of Bristol, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, United Kingdom.
Hengge AC; Department of Chemistry and Biochemistry, Utah State University, Logan, Utah 84322-0300, United States.
Kamerlin SCL; Science for Life Laboratory, Department of Chemistry - BMC, Uppsala University, Box 576, S-751 23 Uppsala, Sweden.
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2021 Mar 17; Vol. 143 (10), pp. 3830-3845. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*metabolism
Allosteric Regulation ; Biocatalysis ; Catalytic Domain ; Humans ; Kinetics ; Molecular Dynamics Simulation ; Protein Stability ; Protein Structure, Tertiary ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/chemistry ; Thermodynamics
Czasopismo naukowe
Tytuł :
miR-34c inhibits proliferation of glioma by targeting PTP1B.
Autorzy :
Shu Y; Key Laboratory of Brain Science, Zunyi Medical University, Zunyi 563000, China.
Yao S; Department of Cerebrovascular Disease, Affiliated Hospital of Zunyi Medical University, Zunyi Medical University, Zunyi 563000, China.
Cai S; Key Laboratory of Brain Science, Zunyi Medical University, Zunyi 563000, China.
Li J; Key Laboratory of Brain Science, Zunyi Medical University, Zunyi 563000, China.
He L; Key Laboratory of Brain Science, Zunyi Medical University, Zunyi 563000, China.
Zou J; Key Laboratory of Brain Science, Zunyi Medical University, Zunyi 563000, China.
Zhang Q; Department of Cerebrovascular Disease, Affiliated Hospital of Zunyi Medical University, Zunyi Medical University, Zunyi 563000, China.
Fan H; Department of Microbiology, Zunyi Medical University, Zunyi 563000, China.
Zhou L; Key Laboratory of Brain Science, Zunyi Medical University, Zunyi 563000, China.
Yu S; Key Laboratory of Brain Science, Zunyi Medical University, Zunyi 563000, China.
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Źródło :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2021 Mar 02; Vol. 53 (3), pp. 325-332.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation*
Glioma/*metabolism
MicroRNAs/*metabolism
Neoplasm Proteins/*metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*metabolism
RNA, Neoplasm/*metabolism
Animals ; Cell Line, Tumor ; Glioma/genetics ; Glioma/pathology ; Humans ; Mice ; MicroRNAs/genetics ; Neoplasm Invasiveness ; Neoplasm Proteins/genetics ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/pathology ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/genetics ; RNA, Neoplasm/genetics
Czasopismo naukowe
Tytuł :
Discovery of 5-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzylidene)thiazolidine-2,4-dione as a novel potent protein tyrosine phosphatase 1B inhibitor with antidiabetic properties.
Autorzy :
Jiang B; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China.
Luo J; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
Guo S; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China.
Wang L; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Mar; Vol. 108, pp. 104648. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
Diabetes Mellitus, Experimental/*drug therapy
Enzyme Inhibitors/*pharmacology
Hypoglycemic Agents/*pharmacology
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*antagonists & inhibitors
Animals ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Hypoglycemic Agents/chemical synthesis ; Hypoglycemic Agents/chemistry ; Male ; Mice ; Mice, Congenic ; Molecular Structure ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Flavonoids from Sophora alopecuroides L. improve palmitate-induced insulin resistance by inhibiting PTP1B activity in vitro.
Autorzy :
Zhang M; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.
Zhang Y; Chinese Medicine Research Institute, Shandong Hongjitang Pharmaceutical Group Co., Ltd., Jinan 250103, China.
Huang Q; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.
Duan H; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.
Zhao G; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.
Liu L; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China. Electronic address: .
Li Y; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Mar 01; Vol. 35, pp. 127775. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enzyme Inhibitors/*pharmacology
Flavonoids/*pharmacology
Palmitates/*pharmacology
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*antagonists & inhibitors
Sophora/*chemistry
Animals ; Cell Differentiation/drug effects ; Cell Line ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/isolation & purification ; Flavonoids/chemistry ; Flavonoids/isolation & purification ; Insulin Resistance ; Mice ; Molecular Structure ; Palmitates/chemistry ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity.
Autorzy :
Ghosh S; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Liu H; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Yazdankhah M; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Stepicheva N; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Shang P; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Vaidya T; GROW Research Laboratory, Narayana Nethralaya Foundation, Bengaluru, India.
Hose S; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Gupta U; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Calderon MJ; Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Hu MW; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nair AP; GROW Research Laboratory, Narayana Nethralaya Foundation, Bengaluru, India.
Weiss J; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Fitting CS; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Bhutto IA; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gadde SGK; GROW Research Laboratory, Narayana Nethralaya Foundation, Bengaluru, India.
Naik NK; GROW Research Laboratory, Narayana Nethralaya Foundation, Bengaluru, India.
Jaydev C; GROW Research Laboratory, Narayana Nethralaya Foundation, Bengaluru, India.
Lutty GA; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Handa JT; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jayagopal A; Kodiak Sciences, Palo Alto, CA, USA.
Qian J; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sahel JA; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Institut de la Vision, INSERM, CNRS, Sorbonne Université, Paris, France.
Rajasundaram D; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Sergeev Y; National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Zigler JS Jr; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sethu S; GROW Research Laboratory, Narayana Nethralaya Foundation, Bengaluru, India.
Watkins S; Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Ghosh A; GROW Research Laboratory, Narayana Nethralaya Foundation, Bengaluru, India.
Sinha D; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. .; Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. .; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. .
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Źródło :
Communications biology [Commun Biol] 2021 Feb 24; Vol. 4 (1), pp. 248. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Energy Metabolism*
Astrocytes/*enzymology
Diabetic Retinopathy/*enzymology
Glucose/*metabolism
Mitochondria/*enzymology
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*metabolism
Retina/*enzymology
beta-Crystallin A Chain/*metabolism
Animals ; Astrocytes/pathology ; Case-Control Studies ; Cells, Cultured ; Crystallins/genetics ; Crystallins/metabolism ; Diabetic Retinopathy/genetics ; Diabetic Retinopathy/pathology ; Disease Models, Animal ; Humans ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/genetics ; Mitochondria/pathology ; Protein Binding ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/genetics ; Rats, Sprague-Dawley ; Retina/pathology ; beta-Crystallin A Chain/genetics
Czasopismo naukowe
Tytuł :
Optogenetic Analysis of Allosteric Control in Protein Tyrosine Phosphatases.
Autorzy :
Hongdusit A; Department of Chemical and Biological Engineering, University of Colorado-Boulder, 3415 Colorado Avenue, Boulder, Colorado 80303, United States.
Fox JM; Department of Chemical and Biological Engineering, University of Colorado-Boulder, 3415 Colorado Avenue, Boulder, Colorado 80303, United States.
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Źródło :
Biochemistry [Biochemistry] 2021 Feb 02; Vol. 60 (4), pp. 254-258. Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Optogenetics*
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*chemistry
Protein Tyrosine Phosphatase, Non-Receptor Type 2/*chemistry
Allosteric Regulation ; Humans ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/genetics
Czasopismo naukowe
Tytuł :
PTP1B negatively regulates STAT1-independent Pseudomonas aeruginosa killing by macrophages.
Autorzy :
Yue L; The Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China.
Yan M; Department of Microbiology and Immunology, Kunming Medical University, Kunming, Yunnan, China.
Chen S; Department of Microbiology and Immunology, Kunming Medical University, Kunming, Yunnan, China.
Cao H; The Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China.
Li H; The Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China. Electronic address: .
Xie Z; The Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Dec 10; Vol. 533 (3), pp. 296-303. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Host-Pathogen Interactions/*genetics
Macrophages/*immunology
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*genetics
Pseudomonas Infections/*genetics
Pseudomonas aeruginosa/*immunology
STAT1 Transcription Factor/*genetics
Animals ; Chemokine CXCL10/genetics ; Chemokine CXCL10/immunology ; Chemokine CXCL2/genetics ; Chemokine CXCL2/immunology ; Gene Expression Regulation ; Host-Pathogen Interactions/immunology ; Humans ; Interferon-gamma/genetics ; Interferon-gamma/immunology ; Interleukin-1beta/genetics ; Interleukin-1beta/immunology ; Interleukin-6/genetics ; Interleukin-6/immunology ; Macrophages/microbiology ; Mice ; Mice, Knockout ; Nitric Oxide/immunology ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/immunology ; Phagocytosis ; Primary Cell Culture ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/deficiency ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/immunology ; Pseudomonas Infections/immunology ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/pathogenicity ; STAT1 Transcription Factor/immunology ; Signal Transduction ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/immunology
Czasopismo naukowe
Tytuł :
In Search for Multi-Target Ligands as Potential Agents for Diabetes Mellitus and Its Complications-A Structure-Activity Relationship Study on Inhibitors of Aldose Reductase and Protein Tyrosine Phosphatase 1B.
Autorzy :
Ottanà R; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Palatucci, Polo Universitario Annunziata, 98168 Messina, Italy.
Paoli P; Department of Scienze Biomediche Sperimentali e Cliniche, Sezione di Scienze Biochimiche, University of Firenze, Viale Morgagni 50, 50134 Firenze, Italy.
Cappiello M; Department of Biology, Biochemistry Unit, University of Pisa, Via S. Zeno, 51, 56123 Pisa, Italy.
Nguyen TN; Molecular Design Lab, Institute of Pharmacy, Freie Universität Berlin, Königin-Luisestr. 2 + 4, 14195 Berlin, Germany.
Adornato I; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Palatucci, Polo Universitario Annunziata, 98168 Messina, Italy.
Del Corso A; Department of Biology, Biochemistry Unit, University of Pisa, Via S. Zeno, 51, 56123 Pisa, Italy.
Genovese M; Department of Scienze Biomediche Sperimentali e Cliniche, Sezione di Scienze Biochimiche, University of Firenze, Viale Morgagni 50, 50134 Firenze, Italy.
Nesi I; Department of Scienze Biomediche Sperimentali e Cliniche, Sezione di Scienze Biochimiche, University of Firenze, Viale Morgagni 50, 50134 Firenze, Italy.
Moschini R; Department of Biology, Biochemistry Unit, University of Pisa, Via S. Zeno, 51, 56123 Pisa, Italy.
Naß A; Molecular Design Lab, Institute of Pharmacy, Freie Universität Berlin, Königin-Luisestr. 2 + 4, 14195 Berlin, Germany.
Wolber G; Molecular Design Lab, Institute of Pharmacy, Freie Universität Berlin, Königin-Luisestr. 2 + 4, 14195 Berlin, Germany.
Maccari R; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Palatucci, Polo Universitario Annunziata, 98168 Messina, Italy.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jan 10; Vol. 26 (2). Date of Electronic Publication: 2021 Jan 10.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/pharmacology
Hypoglycemic Agents*/chemistry
Hypoglycemic Agents*/pharmacology
Aldehyde Reductase/*antagonists & inhibitors
Diabetes Mellitus/*drug therapy
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*antagonists & inhibitors
Aldehyde Reductase/metabolism ; Animals ; Diabetes Mellitus/enzymology ; Drug Evaluation, Preclinical ; Hep G2 Cells ; Humans ; Ligands ; Mice ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
l-Lactate Dehydrogenase Identified as a Protein Tyrosine Phosphatase 1B Substrate by Using K-BIPS.
Autorzy :
Acharige NPN; Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI, 48202, USA.
Pflum MKH; Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI, 48202, USA.
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Źródło :
Chembiochem : a European journal of chemical biology [Chembiochem] 2021 Jan 05; Vol. 22 (1), pp. 186-192. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
L-Lactate Dehydrogenase/*analysis
Phosphoric Monoester Hydrolases/*metabolism
Phosphotransferases/*metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*metabolism
Biocatalysis ; Biotinylation ; Humans ; L-Lactate Dehydrogenase/metabolism ; Molecular Conformation ; Phosphoric Monoester Hydrolases/chemistry ; Phosphotransferases/chemistry ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/chemistry ; Substrate Specificity
Czasopismo naukowe
Tytuł :
5-Aryl-furan derivatives bearing a phenylalanine- or isoleucine-derived rhodanine moiety as potential PTP1B inhibitors.
Autorzy :
Niu T; College of Medicine, Yanbian University, Yanji 133000, China; China-Japan Union Hospital of Jilin University, Changchun 130033, China.
Wang P; National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai 201203, China.
Li C; College of Medicine, Yanbian University, Yanji 133000, China; Department of Pharmacy, Yanbian University Hospital, Yanji 133000, China.
Dou T; College of Pharmacy, Yanbian University, Yanji 133000, China.
Piao H; College of Pharmacy, Yanbian University, Yanji 133000, China.
Li J; National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: .
Sun L; College of Medicine, Yanbian University, Yanji 133000, China; College of Pharmacy, Yanbian University, Yanji 133000, China. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Jan; Vol. 106, pp. 104483. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enzyme Inhibitors/*pharmacology
Furans/*pharmacology
Isoleucine/*pharmacology
Phenylalanine/*pharmacology
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*antagonists & inhibitors
Rhodanine/*pharmacology
Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Furans/chemical synthesis ; Furans/chemistry ; Humans ; Isoleucine/chemistry ; Molecular Structure ; Phenylalanine/chemistry ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Rhodanine/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Effectiveness of cyclohexyl functionality in ugonins from Helminthostachys zeylanica to PTP1B and α-glucosidase inhibitions.
Autorzy :
Shah AB; Division of Applied Life Science (BK21 plus), IALS, Gyeongsang National University, Jinju 52828, Republic of Korea.
Yoon S; Division of Life Science, Department of Bio & Medical Big-data (BK21 plus), RINS, Gyeongsang National University, Jinju 52828, Republic of Korea.
Kim JH; Division of Applied Life Science (BK21 plus), IALS, Gyeongsang National University, Jinju 52828, Republic of Korea.
Zhumanova K; Division of Applied Life Science (BK21 plus), IALS, Gyeongsang National University, Jinju 52828, Republic of Korea.
Ban YJ; Division of Applied Life Science (BK21 plus), IALS, Gyeongsang National University, Jinju 52828, Republic of Korea.
Lee KW; Division of Life Science, Department of Bio & Medical Big-data (BK21 plus), RINS, Gyeongsang National University, Jinju 52828, Republic of Korea. Electronic address: .
Park KH; Division of Applied Life Science (BK21 plus), IALS, Gyeongsang National University, Jinju 52828, Republic of Korea. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Dec 15; Vol. 165 (Pt B), pp. 1822-1831. Date of Electronic Publication: 2020 Oct 17.
Typ publikacji :
Journal Article
MeSH Terms :
Cyclohexanes/*chemistry
Flavonoids/*chemistry
Flavonoids/*isolation & purification
Glycoside Hydrolase Inhibitors/*pharmacology
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*antagonists & inhibitors
Tracheophyta/*chemistry
alpha-Glucosidases/*metabolism
Flavonoids/pharmacology ; Humans ; Kinetics ; Molecular Docking Simulation ; Protein Binding ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/chemistry ; Spectrometry, Fluorescence
Czasopismo naukowe
Tytuł :
One-step partial synthesis of (±)-asperteretone B and related hPTP1B 1-400 inhibitors from butyrolactone I.
Autorzy :
Rivera-Chávez J; Departamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria 04510, Ciudad de México, Mexico. Electronic address: .
Coporo-Blancas D; Departamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria 04510, Ciudad de México, Mexico.
Morales-Jiménez J; CONACYT-Consorcio de Investigación, Innovación y Desarrollo para las Zonas Áridas (CIIDZA), Instituto Potosino de Investigación Científica y Tecnológica A. C., Camino a la Presa San José 2055, Lomas 4a sección, 78216 San Luis Potosí, Mexico.
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 Dec 15; Vol. 28 (24), pp. 115817. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
4-Butyrolactone/*analogs & derivatives
Enzyme Inhibitors/*chemical synthesis
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*antagonists & inhibitors
4-Butyrolactone/chemistry ; 4-Butyrolactone/metabolism ; Aspergillus/chemistry ; Aspergillus/metabolism ; Binding Sites ; Drug Design ; Enzyme Inhibitors/metabolism ; Humans ; Molecular Docking Simulation ; Principal Component Analysis ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Stereoisomerism ; Structure-Activity Relationship
SCR Organism :
Aspergillus terreus
Czasopismo naukowe
Tytuł :
MiR-590-3p regulates cardiomyocyte P19CL6 proliferation, apoptosis and differentiation in vitro by targeting PTPN1 via JNK/STAT/NF-kB pathway.
Autorzy :
Wang F; Department of Cardiac Surgery, Zhongshan Hospital of Fudan University, Shanghai, China.
Zhang H; Department of Cardiac Surgery, Zhongshan Hospital of Fudan University, Shanghai, China.
Wang C; Department of Cardiac Surgery, Zhongshan Hospital of Fudan University, Shanghai, China.
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Źródło :
International journal of experimental pathology [Int J Exp Pathol] 2020 Dec; Vol. 101 (6), pp. 196-202. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
MAP Kinase Signaling System*
Signal Transduction*
MicroRNAs/*genetics
NF-kappa B/*metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*metabolism
STAT Transcription Factors/*metabolism
Animals ; Apoptosis ; Cell Differentiation ; Cell Line, Tumor ; Cell Proliferation ; Mice ; Myocytes, Cardiac/physiology ; NF-kappa B/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/genetics ; RNA, Messenger/genetics ; STAT Transcription Factors/genetics
Czasopismo naukowe

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