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Wyszukujesz frazę ""Protein Tyrosine Phosphatase, Non-Receptor Type 1"" wg kryterium: Temat

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Tytuł:
The phosphatidylethanolamine derivative diDCP-LA-PE mimics intracellular insulin signaling.
Autorzy:
Nishizaki T; Innovative Bioinformation Research Organization, Kobe, Japan.
Gotoh A; Laboratory of Cell and Gene Therapy, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan.
Shimizu T; Laboratory of Chemical Biology, Advanced Medicinal Research Center, Hyogo University of Health Sciences, Kobe, Japan.
Tanaka A; Laboratory of Chemical Biology, Advanced Medicinal Research Center, Hyogo University of Health Sciences, Kobe, Japan.
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Źródło:
Scientific reports [Sci Rep] 2016 Jun 02; Vol. 6, pp. 27267. Date of Electronic Publication: 2016 Jun 02.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 1/*drug therapy
Insulin/*metabolism
Phosphatidylethanolamines/*administration & dosage
Signal Transduction/*drug effects
3T3-L1 Cells ; Animals ; Blood Glucose/drug effects ; Cell Differentiation/drug effects ; Cell Membrane/metabolism ; Diabetes Mellitus, Type 1/metabolism ; Disease Models, Animal ; Glucose/metabolism ; Humans ; Mice ; Phosphatidylethanolamines/pharmacology ; Phosphorylation ; Protein Kinase C/metabolism ; Protein Kinase C-epsilon/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population.
Autorzy:
Santiago JL; Immunology Department, Hospital Universitario San Carlos, Madrid, Spain. />Martínez A
de la Calle H
Fernández-Arquero M
Figueredo MA
de la Concha EG
Urcelay E
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Źródło:
BMC medical genetics [BMC Med Genet] 2007 Aug 13; Vol. 8, pp. 54. Date of Electronic Publication: 2007 Aug 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Predisposition to Disease*
Diabetes Mellitus, Type 1/*genetics
Protein Tyrosine Phosphatases/*genetics
Adolescent ; Adult ; Age Factors ; Alleles ; Case-Control Studies ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatase, Non-Receptor Type 22 ; Sex Factors ; Spain
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
CD40 is required for development of islet inflammation in the RIP-CD154 transgenic mouse model of type 1 diabetes.
Autorzy:
Haase C; Hagedorn Research Institute and Novo Nordisk A/S, Department of Immunopharmacology, Novo Nordisk Park, DK-2760 Måløv, Denmark. />Markholst H
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Źródło:
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2007 Jun; Vol. 1107, pp. 373-9.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CD40 Antigens/*metabolism
CD40 Ligand/*metabolism
Diabetes Mellitus, Type 1/*metabolism
Diabetes Mellitus, Type 1/*pathology
Insulin/*metabolism
Pancreatic Diseases/*metabolism
Promoter Regions, Genetic/*genetics
Animals ; CD40 Antigens/deficiency ; CD40 Antigens/genetics ; CD40 Ligand/genetics ; Disease Models, Animal ; Disease Progression ; Inflammation/metabolism ; Inflammation/pathology ; Insulin/genetics ; Leukocyte Common Antigens/metabolism ; Mice ; Mice, Knockout ; Mice, Transgenic ; Pancreatic Diseases/pathology ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genetic determinants of type 1 diabetes across populations.
Autorzy:
Jahromi MM; Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, PO Box 6511, Aurora, CO 80010, USA.
Eisenbarth GS
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Źródło:
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2006 Oct; Vol. 1079, pp. 289-99.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Diabetes Mellitus, Type 1/*genetics
Population Groups/*genetics
Antigens, CD/genetics ; Antigens, Differentiation/genetics ; CTLA-4 Antigen ; Diabetes Mellitus, Type 1/immunology ; Genetic Variation ; HLA-DQ Antigens/genetics ; HLA-DR Antigens/genetics ; Humans ; Insulin/genetics ; Major Histocompatibility Complex/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatase, Non-Receptor Type 22 ; Protein Tyrosine Phosphatases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The 1858T PTPN22 gene variant contributes to a genetic risk of type 1 diabetes in a Ukrainian population.
Autorzy:
Fedetz M; Instituto de Parasitología y Biomedicina López Neyra, CSIC, Granada, Spain.
Matesanz F
Caro-Maldonado A
Smirnov II
Chvorostinka VN
Moiseenko TA
Alcina A
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Źródło:
Tissue antigens [Tissue Antigens] 2006 May; Vol. 67 (5), pp. 430-3.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Polymorphism, Genetic*
Diabetes Mellitus, Type 1/*epidemiology
Diabetes Mellitus, Type 1/*genetics
Population/*genetics
Protein Tyrosine Phosphatases/*genetics
Adolescent ; Adult ; Aged ; Alleles ; Female ; Gene Frequency ; Humans ; Male ; Middle Aged ; Molecular Epidemiology ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatase, Non-Receptor Type 22 ; Risk ; Ukraine/epidemiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
IA-2 antibody isotypes and epitope specificity during the prediabetic process in children with HLA-conferred susceptibility to type I diabetes.
Autorzy:
Hoppu S; Paediatric Research Centre, Medical School, University of Tampere and Department of Paediatrics, Tampere University Hospital, Tampere, Finland.
Härkönen T
Ronkainen MS
Simell S
Hekkala A
Toivonen A
Ilonen J
Simell O
Knip M
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2006 Apr; Vol. 144 (1), pp. 59-66.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autoantibodies/*immunology
Diabetes Mellitus, Type 1/*immunology
Epitopes/*immunology
Child, Preschool ; Cross Reactions/immunology ; Female ; Genotype ; HLA-DQ Antigens/genetics ; HLA-DQ beta-Chains ; Humans ; Immunoglobulin A/immunology ; Immunoglobulin G/immunology ; Immunoglobulin Isotypes/immunology ; Immunoglobulin M/immunology ; Infant ; Male ; Membrane Proteins/immunology ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatases/immunology ; Receptor-Like Protein Tyrosine Phosphatases, Class 8 ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant.
Autorzy:
Vang T; Program on Inflammatory Disease Research, Infectious and Inflammatory Disease Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
Congia M
Macis MD
Musumeci L
Orrú V
Zavattari P
Nika K
Tautz L
Taskén K
Cucca F
Mustelin T
Bottini N
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Źródło:
Nature genetics [Nat Genet] 2005 Dec; Vol. 37 (12), pp. 1317-9. Date of Electronic Publication: 2005 Nov 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Polymorphism, Single Nucleotide*
Autoimmune Diseases/*enzymology
Diabetes Mellitus, Type 1/*enzymology
Protein Tyrosine Phosphatases/*genetics
T-Lymphocytes/*immunology
Alleles ; Antibodies/pharmacology ; Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Catalysis ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/immunology ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Heterozygote ; Humans ; Interleukin-2/metabolism ; Italy ; Lymphocyte Activation ; Male ; Mutation ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatase, Non-Receptor Type 22 ; Receptors, Antigen, T-Cell/drug effects ; Receptors, Antigen, T-Cell/metabolism ; T-Lymphocytes/enzymology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Diminished Th1-like response to autoantigens in children with a high risk of developing type 1 diabetes.
Autorzy:
Karlsson Faresjö MG; Division of Paediatrics and Diabetes Research Centre, Department of Molecular & Clinical Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden. />Ludvigsson J
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Źródło:
Scandinavian journal of immunology [Scand J Immunol] 2005 Feb; Vol. 61 (2), pp. 173-9.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 1/*immunology
Prediabetic State/*immunology
Th1 Cells/*immunology
Adolescent ; Adult ; Autoantigens/immunology ; C-Reactive Protein/metabolism ; Child ; Diabetes Mellitus, Type 1/enzymology ; Enzyme-Linked Immunosorbent Assay ; Female ; Glutamate Decarboxylase/immunology ; Humans ; Insulin/immunology ; Interferon-gamma/immunology ; Interleukin-4/immunology ; Lymphocyte Activation/immunology ; Male ; Middle Aged ; Niacinamide/pharmacology ; Prediabetic State/enzymology ; Proinsulin/blood ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatases/immunology ; Th2 Cells/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population.
Autorzy:
Thude H; Institute for Transfusion Medicine, University of Jena, Jena, Germany. />Rosenhahn S
Hunger-Dathe W
Müller UA
Barz D
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Źródło:
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics [Eur J Immunogenet] 2004 Dec; Vol. 31 (6), pp. 245-7.
Typ publikacji:
Journal Article
MeSH Terms:
Genetic Predisposition to Disease*
Point Mutation*
Diabetes Mellitus, Type 1/*genetics
Leukocyte Common Antigens/*genetics
Diabetes Mellitus, Type 1/immunology ; Exons ; Genotype ; Germany ; Humans ; Leukocyte Common Antigens/immunology ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Sequence Analysis, DNA
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A functional polymorphism (1858C/T) in the PTPN22 gene is linked and associated with type I diabetes in multiplex families.
Autorzy:
Onengut-Gumuscu S; Molecular Genetics Program, Benaroya Research Institute, 1201 Ninth Ave, Seattle, WA 98101, USA.
Ewens KG
Spielman RS
Concannon P
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Źródło:
Genes and immunity [Genes Immun] 2004 Dec; Vol. 5 (8), pp. 678-80.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Genetic Linkage*
Genetic Predisposition to Disease*
Diabetes Mellitus, Type 1/*genetics
Polymorphism, Single Nucleotide/*genetics
Protein Tyrosine Phosphatases/*genetics
Alleles ; Humans ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatase, Non-Receptor Type 22 ; Risk Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes.
Autorzy:
Bottini N; Program of Signal Transduction, Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
Musumeci L
Alonso A
Rahmouni S
Nika K
Rostamkhani M
MacMurray J
Meloni GF
Lucarelli P
Pellecchia M
Eisenbarth GS
Comings D
Mustelin T
Pokaż więcej
Źródło:
Nature genetics [Nat Genet] 2004 Apr; Vol. 36 (4), pp. 337-8. Date of Electronic Publication: 2004 Mar 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 1/*genetics
Protein Tyrosine Phosphatases/*metabolism
Diabetes Mellitus, Type 1/enzymology ; Genetic Markers ; Humans ; Polymorphism, Single Nucleotide ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Islet regeneration during the reversal of autoimmune diabetes in NOD mice.
Autorzy:
Kodama S; Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 3602, Charlestown, MA 02129, USA.
Kühtreiber W
Fujimura S
Dale EA
Faustman DL
Pokaż więcej
Źródło:
Science (New York, N.Y.) [Science] 2003 Nov 14; Vol. 302 (5648), pp. 1223-7.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Cell Transplantation*
Regeneration*
Diabetes Mellitus, Type 1/*physiopathology
Diabetes Mellitus, Type 1/*therapy
Freund's Adjuvant/*therapeutic use
Islets of Langerhans/*physiology
Spleen/*cytology
Stem Cells/*physiology
Animals ; Autoimmunity ; Blood Glucose/analysis ; Cell Differentiation ; Cell Fusion ; Combined Modality Therapy ; Diabetes Mellitus, Type 1/immunology ; Diabetes Mellitus, Type 1/pathology ; Female ; In Situ Hybridization, Fluorescence ; Insulin/analysis ; Islets of Langerhans/pathology ; Islets of Langerhans Transplantation ; Leukocyte Common Antigens/analysis ; Male ; Mice ; Mice, Inbred NOD ; Pancreatic Ducts/cytology ; Ploidies ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Spleen/radiation effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Islet autoantibodies in cord blood from patients who developed type 1 diabetes mellitus at 15-30 years of age.
Autorzy:
Elfving AM; Department of Pediatrics, Lund University Hospital, Lund University, SE-221 85 Lund, Sweden. />Lindberg BA
Nyström L
Sundkvist G
Lernmark A
Ivarsson SA
Pokaż więcej
Corporate Authors:
DISS Study Group
Źródło:
Autoimmunity [Autoimmunity] 2003 Jun; Vol. 36 (4), pp. 227-31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Autoantibodies/*immunology
Diabetes Mellitus, Type 1/*immunology
Fetal Blood/*immunology
Islets of Langerhans/*immunology
Adolescent ; Adult ; Autoantibodies/blood ; Autoantigens ; Diabetes Mellitus, Type 1/blood ; Female ; Glutamate Decarboxylase/blood ; Glutamate Decarboxylase/immunology ; Humans ; Insulin/blood ; Insulin/immunology ; Male ; Membrane Proteins/blood ; Membrane Proteins/immunology ; Prediabetic State/blood ; Prediabetic State/immunology ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatases/blood ; Protein Tyrosine Phosphatases/immunology ; Receptor-Like Protein Tyrosine Phosphatases, Class 8
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Tyrosine phosphatase-like protein (IA-2) and glutamic acid decarboxylase (GAD65) autoantibodies: a study of Chinese patients with diabetes mellitus.
Autorzy:
Ng WY; Department of Medicine, National University of Singapore, Republic of Singapore. />Lee YS
Todd AL
Lui KF
Loke KY
Thai AC
Pokaż więcej
Źródło:
Autoimmunity [Autoimmunity] 2002 Mar; Vol. 35 (2), pp. 119-24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autoantibodies/*immunology
Diabetes Mellitus, Type 1/*immunology
Diabetes Mellitus, Type 2/*immunology
Glutamate Decarboxylase/*immunology
Isoenzymes/*immunology
Protein Tyrosine Phosphatases/*immunology
Adult ; Asian People ; Autoantibodies/blood ; Child ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/diagnosis ; Diabetes Mellitus, Type 1/enzymology ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/enzymology ; Female ; Glutamate Decarboxylase/metabolism ; Humans ; Isoenzymes/metabolism ; Male ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatases/metabolism ; Receptor-Like Protein Tyrosine Phosphatases, Class 8
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
CD45 exon 4 point mutation does not confer susceptibility to type 1 diabetes mellitus or Graves' disease.
Autorzy:
Wood JP; Medical Department 1, Division of Endocrinology, Centre of Internal Medicine, Johann Wolfgang Goethe University Hospital, Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany.
Bieda K
Segni M
Herwig J
Krause M
Usadel KH
Badenhoop K
Pokaż więcej
Źródło:
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics [Eur J Immunogenet] 2002 Feb; Vol. 29 (1), pp. 73-4.
Typ publikacji:
Journal Article
MeSH Terms:
Genetic Predisposition to Disease*
Diabetes Mellitus, Type 1/*genetics
Graves Disease/*genetics
Leukocyte Common Antigens/*genetics
Exons ; Humans ; Protein Tyrosine Phosphatase, Non-Receptor Type 1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
BB rat lyp mutation and Type 1 diabetes.
Autorzy:
Ramanathan S; Arthritis and Immune Disorder Research Centre at the University Health Network, University of Toronto, Ontario, Canada.
Poussier P
Pokaż więcej
Źródło:
Immunological reviews [Immunol Rev] 2001 Dec; Vol. 184, pp. 161-71.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Diabetes Mellitus, Type 1/*genetics
Protein Tyrosine Phosphatases/*genetics
Rats, Mutant Strains/*genetics
Animals ; Diabetes Mellitus, Type 1/immunology ; Humans ; Lymphopenia/immunology ; Lymphopenia/physiopathology ; Mice ; Mitosis ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatase, Non-Receptor Type 22 ; Rats ; Rats, Mutant Strains/immunology ; T-Lymphocytes/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Biochemical markers of type 1 diabetes: clinical use.
Autorzy:
Pozzilli P; Università Campus Biomedico, Rome, Italy. />Manfrini S
Monetini L
Pokaż więcej
Źródło:
Scandinavian journal of clinical and laboratory investigation. Supplementum [Scand J Clin Lab Invest Suppl] 2001; Vol. 235, pp. 38-44.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Diabetes Mellitus, Type 1/*immunology
Animals ; Autoantibodies/blood ; Autoantigens ; Biomarkers/blood ; Glutamate Decarboxylase/immunology ; Humans ; Insulin/immunology ; Isoenzymes/immunology ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatases/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 26

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