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Wyszukujesz frazę ""Protein-Serine-Threonine Kinases"" wg kryterium: Temat


Tytuł :
The interaction of TEA domain transcription factor 4 (TEAD4) and Yes-associated protein 1 (YAP1) promoted the malignant process mediated by serum/glucocorticoid regulated kinase 1 (SGK1).
Autorzy :
He S; Department of Cardiothoracic Surgery, The Second People's Hospital of Chengdu , Chengdu, Sichuan, China.
Zhang H; Department of Thoracic Surgery, West China Hospital of Sichuan University , Chengdu, Sichuan, China.
Xiao Z; Department of Cardiothoracic Surgery, The Second People's Hospital of Chengdu , Chengdu, Sichuan, China.
Bhushan S; Department of Cardiothoracic Surgery, The Second People's Hospital of Chengdu , Chengdu, Sichuan, China.
Gao K; Department of Cardiothoracic Surgery, The Second People's Hospital of Chengdu , Chengdu, Sichuan, China.
Wang W; Department of Thoracic Surgery, West China Hospital of Sichuan University , Chengdu, Sichuan, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 601-614.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
DNA-Binding Proteins*/genetics
DNA-Binding Proteins*/metabolism
Immediate-Early Proteins*/genetics
Immediate-Early Proteins*/metabolism
Muscle Proteins*/genetics
Muscle Proteins*/metabolism
Protein-Serine-Threonine Kinases*/genetics
Protein-Serine-Threonine Kinases*/metabolism
Transcription Factors*/genetics
Transcription Factors*/metabolism
Gene Expression Regulation, Neoplastic/*genetics
Animals ; Cell Line, Tumor ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/genetics ; Esophageal Squamous Cell Carcinoma/metabolism ; Esophageal Squamous Cell Carcinoma/pathology ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude
Czasopismo naukowe
Tytuł :
Gene of the month: STK11 .
Autorzy :
Zyla RE; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Hahn E; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Anatomic Pathology, University Health Network, Toronto, Ontario, Canada.
Hodgson A; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada .; Anatomic Pathology, University Health Network, Toronto, Ontario, Canada.
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Źródło :
Journal of clinical pathology [J Clin Pathol] 2021 Nov; Vol. 74 (11), pp. 681-685. Date of Electronic Publication: 2021 Sep 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Mutation*
Protein-Serine-Threonine Kinases*/genetics
Protein-Serine-Threonine Kinases*/metabolism
Protein-Serine-Threonine Kinases*/physiology
Neoplasms/*genetics
Peutz-Jeghers Syndrome/*genetics
Humans
Czasopismo naukowe
Tytuł :
GAK and PRKCD are positive regulators of PRKN-independent mitophagy.
Autorzy :
Munson MJ; Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, N-0372, Oslo, Norway. .; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0316, Oslo, Norway. .; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. .
Mathai BJ; Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, N-0372, Oslo, Norway.; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0316, Oslo, Norway.
Ng MYW; Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, N-0372, Oslo, Norway.; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0316, Oslo, Norway.
Trachsel-Moncho L; Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, N-0372, Oslo, Norway.; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0316, Oslo, Norway.
de la Ballina LR; Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, N-0372, Oslo, Norway.; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0316, Oslo, Norway.
Schultz SW; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0316, Oslo, Norway.; Department of Molecular Cell Biology, The Norwegian Radium Hospital Montebello, N-0379, Oslo, Norway.
Aman Y; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478, Lørenskog, Norway.
Lystad AH; Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, N-0372, Oslo, Norway.; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0316, Oslo, Norway.
Singh S; Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, N-0372, Oslo, Norway.; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0316, Oslo, Norway.
Singh S; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0316, Oslo, Norway.; Department of Tumor Biology, The Norwegian Radium Hospital Montebello, N-0379, Oslo, Norway.
Wesche J; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0316, Oslo, Norway.; Department of Tumor Biology, The Norwegian Radium Hospital Montebello, N-0379, Oslo, Norway.
Fang EF; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478, Lørenskog, Norway.
Simonsen A; Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, N-0372, Oslo, Norway. .; Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, N-0316, Oslo, Norway. .; Department of Molecular Cell Biology, The Norwegian Radium Hospital Montebello, N-0379, Oslo, Norway. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 20; Vol. 12 (1), pp. 6101. Date of Electronic Publication: 2021 Oct 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitophagy*/drug effects
Intracellular Signaling Peptides and Proteins/*metabolism
Protein Kinase C-delta/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Animals ; Autophagy ; Autophagy-Related Protein-1 Homolog/metabolism ; Autophagy-Related Proteins/metabolism ; Caenorhabditis elegans ; Cell Line, Tumor ; Deferiprone/pharmacology ; Fatty Acid-Binding Proteins/genetics ; Fatty Acid-Binding Proteins/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors ; Intracellular Signaling Peptides and Proteins/genetics ; Lysosomes/metabolism ; Mitochondria/metabolism ; Protein Kinase C-delta/antagonists & inhibitors ; Protein Kinase C-delta/genetics ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Serine-Threonine Kinases/genetics ; Zebrafish
Czasopismo naukowe
Tytuł :
Loss of haspin suppresses cancer cell proliferation by interfering with cell cycle progression at multiple stages.
Autorzy :
Wang P; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, P. R. China.; Division of Pharmaceutical Sciences, School of Pharmacy, The University of Wisconsin, Madison, Wisconsin, USA.
Hua X; Division of Pharmaceutical Sciences, School of Pharmacy, The University of Wisconsin, Madison, Wisconsin, USA.
Sun Y; Division of Pharmaceutical Sciences, School of Pharmacy, The University of Wisconsin, Madison, Wisconsin, USA.
Li H; Division of Pharmaceutical Sciences, School of Pharmacy, The University of Wisconsin, Madison, Wisconsin, USA.
Bryner YH; Division of Pharmaceutical Sciences, School of Pharmacy, The University of Wisconsin, Madison, Wisconsin, USA.
Hsung RP; Division of Pharmaceutical Sciences, School of Pharmacy, The University of Wisconsin, Madison, Wisconsin, USA.
Dai J; Division of Pharmaceutical Sciences, School of Pharmacy, The University of Wisconsin, Madison, Wisconsin, USA.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Oct; Vol. 35 (10), pp. e21923.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle*/drug effects
Cell Cycle*/genetics
Cell Proliferation*/drug effects
Cell Proliferation*/genetics
Intracellular Signaling Peptides and Proteins/*deficiency
Neoplasms/*pathology
Protein-Serine-Threonine Kinases/*deficiency
Cell Line, Tumor ; Fluorescent Dyes ; G1 Phase Cell Cycle Checkpoints/drug effects ; G2 Phase/drug effects ; Humans ; Interphase/drug effects ; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors ; Intracellular Signaling Peptides and Proteins/genetics ; Mitosis/drug effects ; Neoplasms/genetics ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Serine-Threonine Kinases/genetics ; S Phase/drug effects ; Tubercidin/analogs & derivatives ; Tubercidin/pharmacology ; Tumor Suppressor Protein p53/genetics ; Ubiquitination ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
MicroRNA miR-330-3p suppresses the progression of ovarian cancer by targeting RIPK4.
Autorzy :
Cai L; Department of Oncology, Jiangxi Maternal and Child Health Hospital , Nanchang, Jiangxi, China.
Ye L; Department of Pathology, Jiangxi Maternal and Child Health Hospital , Nanchang, Jiangxi, China.
Hu X; Department of Oncology, Jiangxi Maternal and Child Health Hospital , Nanchang, Jiangxi, China.
He W; Jiangxi Key Laboratory of Molecular Medicine, The Second Affiliated Hospital of Nanchang University , Nanchang, Jiangxi, China.
Zhuang D; Department of Pathology, Jiangxi Maternal and Child Health Hospital , Nanchang, Jiangxi, China.
Guo Q; Department of Pathology, Jiangxi Maternal and Child Health Hospital , Nanchang, Jiangxi, China.
Shu K; Department of Oncology, Jiangxi Maternal and Child Health Hospital , Nanchang, Jiangxi, China.
Jie Y; Department of Pathology, Jiangxi Maternal and Child Health Hospital , Nanchang, Jiangxi, China.; Department of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University , Nanchang, Jiangxi, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 440-449.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
MicroRNAs*/metabolism
MicroRNAs*/pharmacology
Ovarian Neoplasms*/metabolism
Ovarian Neoplasms*/pathology
Protein-Serine-Threonine Kinases*/metabolism
Cell Movement/drug effects ; Cell Proliferation/drug effects ; Disease Progression ; Female ; Humans ; Middle Aged ; Ovary/chemistry ; Ovary/metabolism
Czasopismo naukowe
Tytuł :
Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach.
Autorzy :
Chao MW; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Lin TE; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Master Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
HuangFu WC; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.
Chang CD; Ph.D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Tu HJ; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chen LC; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, P. R. China.
Yen SC; Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, P. R. China.; School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, P. R. China.
Sung TY; Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan.
Huang WJ; Ph.D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.; School of Pharmacy, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan.
Yang CR; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Pan SL; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.; Biomedical Commercialization Center, Taipei Medical University, Taipei, Taiwan.
Hsu KC; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.; Biomedical Commercialization Center, Taipei Medical University, Taipei, Taiwan.; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 98-108.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Protein-Serine-Threonine Kinases/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Protein-Serine-Threonine Kinases/metabolism ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
MAPK interacting serine/threonine kinase 1 ( MKNK1 ), one target gene of miR-223-3p, correlates with neutrophils in sepsis based on bioinformatic analysis.
Autorzy :
Fu M; Department of Intensive Care Unit, Huzhou Cent Hosp, Affiliated Cent Hosp HuZhou University, Huzhou, Zhejiang, Peoples R China.
Zhang K; Department of Emergency, Huzhou Cent Hosp, Affiliated Cent Hosp HuZhou University, Huzhou, Zhejiang, Peoples R China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 2550-2562.
Typ publikacji :
Journal Article
MeSH Terms :
Computational Biology*
Intracellular Signaling Peptides and Proteins/*genetics
MicroRNAs/*metabolism
Neutrophils/*metabolism
Protein-Serine-Threonine Kinases/*genetics
Sepsis/*genetics
Gene Expression Profiling ; Humans ; Immunity/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; MicroRNAs/genetics ; Neutrophils/immunology ; Protein Interaction Maps/genetics ; Protein-Serine-Threonine Kinases/metabolism ; ROC Curve ; Reproducibility of Results ; Sepsis/immunology ; Sepsis/pathology
Czasopismo naukowe
Tytuł :
Intermittent hypoxia aggravates non-alcoholic fatty liver disease via RIPK3-dependent necroptosis-modulated Nrf2/NFκB signaling pathway.
Autorzy :
Zhang H; Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.
Zhou L; Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.
Zhou Y; Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.
Wang L; Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.
Jiang W; Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.
Liu L; Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.
Yue S; Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.
Zheng P; Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.
Liu H; Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Nov 15; Vol. 285, pp. 119963. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji :
Journal Article
MeSH Terms :
Necroptosis*
Hypoxia/*complications
NF-E2-Related Factor 2/*metabolism
NF-kappa B/*metabolism
Non-alcoholic Fatty Liver Disease/*complications
Non-alcoholic Fatty Liver Disease/*pathology
Receptor-Interacting Protein Serine-Threonine Kinases/*metabolism
Sleep Apnea, Obstructive/*complications
Animals ; Cell Line ; Hepatocytes/drug effects ; Hepatocytes/pathology ; Humans ; Hydroquinones/pharmacology ; Hypoxia/metabolism ; Male ; Mice ; Mice, Inbred Strains ; Oxidative Stress ; Palmitic Acid/pharmacology ; Receptor-Interacting Protein Serine-Threonine Kinases/genetics ; Signal Transduction ; Sleep Apnea, Obstructive/metabolism
Czasopismo naukowe
Tytuł :
ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR.
Autorzy :
Feldman HC; Department of Chemistry, University of Washington, Seattle, WA, USA.
Ghosh R; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.
Auyeung VC; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.
Mueller JL; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, University of California, San Francisco, San Francisco, CA, USA.
Kim JH; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.
Potter ZE; Department of Chemistry, University of Washington, Seattle, WA, USA.
Vidadala VN; Department of Chemistry, University of Washington, Seattle, WA, USA.
Perera BGK; Department of Chemistry, University of Washington, Seattle, WA, USA.
Olivier A; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.
Backes BJ; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA.
Zikherman J; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, University of California, San Francisco, San Francisco, CA, USA.
Papa FR; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. .; Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA. .; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA. .; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA. .; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA. .
Maly DJ; Department of Chemistry, University of Washington, Seattle, WA, USA. .; Department of Biochemistry, University of Washington, Seattle, WA, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Nov; Vol. 17 (11), pp. 1148-1156. Date of Electronic Publication: 2021 Sep 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Triphosphate/*pharmacology
Endoribonucleases/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Protein-Serine-Threonine Kinases/*antagonists & inhibitors
Adenosine Triphosphate/chemistry ; Endoribonucleases/metabolism ; Humans ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/chemistry ; Protein Unfolding/drug effects ; Protein-Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.
Autorzy :
Matsuki T; Department of Cellular Pathology, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai 480-0392, Japan .
Iio A; Department of Cellular Pathology, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai 480-0392, Japan.; Biogate Co. Ltd., Gifu 501-2123, Japan.
Ueda M; Department of Cellular Pathology, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai 480-0392, Japan.
Tsuneura Y; Department of Cellular Pathology, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai 480-0392, Japan.
Howell BW; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York 13210.
Nakayama A; Department of Cellular Pathology, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai 480-0392, Japan.; Laboratory of Neurochemistry, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2021 Oct 27; Vol. 41 (43), pp. 8887-8903. Date of Electronic Publication: 2021 Sep 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebral Cortex/*embryology
Cerebral Cortex/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
rho GTP-Binding Proteins/*metabolism
Animals ; Cells, Cultured ; Female ; Gene Knockdown Techniques ; HEK293 Cells ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Pregnancy ; Protein-Serine-Threonine Kinases/genetics ; rho GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
CDKL5 Deficiency Augments Inhibitory Input into the Dentate Gyrus That Can Be Reversed by Deep Brain Stimulation.
Autorzy :
Hao S; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030.; Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Wang Q; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030.; Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Tang B; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030.; Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Wu Z; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030.; Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Yang T; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030.; Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.; Department of Neurology, People's Hospital of Guizhou Province, Guiyang, 560000, China.
Tang J; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030 .; Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2021 Oct 27; Vol. 41 (43), pp. 9031-9046. Date of Electronic Publication: 2021 Sep 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Deep Brain Stimulation/*methods
Dentate Gyrus/*metabolism
Epileptic Syndromes/*metabolism
Epileptic Syndromes/*therapy
Neural Inhibition/*physiology
Protein-Serine-Threonine Kinases/*deficiency
Spasms, Infantile/*metabolism
Spasms, Infantile/*therapy
Animals ; Avoidance Learning/physiology ; Epileptic Syndromes/genetics ; Fear/physiology ; Female ; Male ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Transgenic ; Organ Culture Techniques ; Protein-Serine-Threonine Kinases/genetics ; Spasms, Infantile/genetics
SCR Disease Name :
CDKL5 deficiency disorder
Czasopismo naukowe
Tytuł :
Overview of PCTK3/CDK18: A Cyclin-Dependent Kinase Involved in Specific Functions in Post-Mitotic Cells.
Autorzy :
de Oliveira Pepino R; Department of Chemistry and Molecular Physics, Sao Carlos Institute of Chemistry, University of Sao Paulo (USP), P.O. Box 780, Sao Carlos, 13560-970, Brazil.
Coelho F; Department of Chemistry and Molecular Physics, Sao Carlos Institute of Chemistry, University of Sao Paulo (USP), P.O. Box 780, Sao Carlos, 13560-970, Brazil.
Janku TAB; Department of Chemistry and Molecular Physics, Sao Carlos Institute of Chemistry, University of Sao Paulo (USP), P.O. Box 780, Sao Carlos, 13560-970, Brazil.
Alencar DP; Department of Chemistry and Molecular Physics, Sao Carlos Institute of Chemistry, University of Sao Paulo (USP), P.O. Box 780, Sao Carlos, 13560-970, Brazil.
de Azevedo WF; Pontifical Catholic University of Rio Grande do Sul (PUCRS), School of Health and Life Sciences, Av. Ipiranga, 6681 Porto Alegre/RS 90619-900, Brazil.
Canduri F; Department of Chemistry and Molecular Physics, Sao Carlos Institute of Chemistry, University of Sao Paulo (USP), P.O. Box 780, Sao Carlos, 13560-970, Brazil.
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Źródło :
Current medicinal chemistry [Curr Med Chem] 2021 Oct 25; Vol. 28 (33), pp. 6846-6865.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cyclin-Dependent Kinases*/metabolism
Protein-Serine-Threonine Kinases*
Cell Cycle ; Cell Cycle Checkpoints ; Cyclin-Dependent Kinase 2 ; Phosphorylation
Czasopismo naukowe
Tytuł :
RIPK1 regulates starvation resistance by modulating aspartate catabolism.
Autorzy :
Mei X; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, P. R. China.; Center for Clinical Research and Translational Medicine, Yangpu Hospital, Tongji University School of Medicine, Shanghai, P.R. China.
Guo Y; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, P. R. China.; University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Xie Z; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, P. R. China.; University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Zhong Y; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, P. R. China.
Wu X; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, P. R. China.; University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Xu D; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, P. R. China.
Li Y; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, P. R. China.
Liu N; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, P. R. China.
Zhu ZJ; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, P. R. China. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 22; Vol. 12 (1), pp. 6144. Date of Electronic Publication: 2021 Oct 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aspartic Acid/*metabolism
Receptor-Interacting Protein Serine-Threonine Kinases/*metabolism
Starvation/*metabolism
AMP-Activated Protein Kinases/metabolism ; Adenosine Triphosphate/biosynthesis ; Animals ; Animals, Newborn ; Aspartic Acid/pharmacology ; Autophagy/drug effects ; Autophagy-Related Protein-1 Homolog/metabolism ; Cell Line ; Cell Nucleus/metabolism ; Cell Survival ; Citric Acid Cycle ; Humans ; Metabolomics ; Mice ; Receptor-Interacting Protein Serine-Threonine Kinases/deficiency ; Signal Transduction ; Sp1 Transcription Factor/genetics ; Sp1 Transcription Factor/metabolism ; Starvation/genetics ; Starvation/mortality
Czasopismo naukowe
Tytuł :
[RIP1/RIP3-MLKL signaling pathway correlates with occurrence, progression and prognosis of chronic heart failure].
Autorzy :
Chen Y; Department of Cardiology, First Affiliated Hospital, Bengbu Medical College, Bengbu 233000, China.; Cardiovascular and Cerebrovascular Disease Research Center, Bengbu Medical College, Bengbu 233000, China.
Li X; Department of Cardiology, First Affiliated Hospital, Bengbu Medical College, Bengbu 233000, China.; Cardiovascular and Cerebrovascular Disease Research Center, Bengbu Medical College, Bengbu 233000, China.
Lai W; Class 1, Grade 2017, School of Medical Imaging, Bengbu Medical College, Bengbu 233000, China.
Zhu F; Department of Cardiology, First Affiliated Hospital, Bengbu Medical College, Bengbu 233000, China.
Tan X; Department of Cardiology, First Affiliated Hospital, Bengbu Medical College, Bengbu 233000, China.; Cardiovascular and Cerebrovascular Disease Research Center, Bengbu Medical College, Bengbu 233000, China.
Xian W; Department of Cardiology, First Affiliated Hospital, Bengbu Medical College, Bengbu 233000, China.; Cardiovascular and Cerebrovascular Disease Research Center, Bengbu Medical College, Bengbu 233000, China.
Kang P; Department of Cardiology, First Affiliated Hospital, Bengbu Medical College, Bengbu 233000, China.
Wang H; Department of Cardiology, First Affiliated Hospital, Bengbu Medical College, Bengbu 233000, China.
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Źródło :
Nan fang yi ke da xue xue bao = Journal of Southern Medical University [Nan Fang Yi Ke Da Xue Xue Bao] 2021 Oct 20; Vol. 41 (10), pp. 1534-1539.
Typ publikacji :
Journal Article
MeSH Terms :
Heart Failure*
Receptor-Interacting Protein Serine-Threonine Kinases*/metabolism
Follow-Up Studies ; Humans ; Necrosis ; Prognosis ; Protein Kinases/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Discovery of an Allosteric, Inactive Conformation-Selective Inhibitor of Full-Length HPK1 Utilizing a Kinase Cascade Assay.
Autorzy :
Wang W; Discovery Technologies and Molecular Pharmacology, Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.
Mevellec L; Discovery Chemistry, Janssen Research and Development, Campus de Maigremont, Val de Reuil 27106, France.
Liu A; Discovery Technologies and Molecular Pharmacology, Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.
Struble G; Discovery Technologies and Molecular Pharmacology, Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.
Miller R; Discovery Technologies and Molecular Pharmacology, Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.
Allen SJ; Discovery Technologies and Molecular Pharmacology, Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.
Federowicz K; Discovery Technologies and Molecular Pharmacology, Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.
Wroblowski B; Computational Chemistry, Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium.
Vialard J; Oncology Discovery Biology, Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium.
Ahn K; Discovery Technologies and Molecular Pharmacology, Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.
Krosky D; Discovery Technologies and Molecular Pharmacology, Janssen Research and Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.
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Źródło :
Biochemistry [Biochemistry] 2021 Oct 19; Vol. 60 (41), pp. 3114-3124. Date of Electronic Publication: 2021 Oct 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Kinase Inhibitors/*chemistry
Protein-Serine-Threonine Kinases/*antagonists & inhibitors
Pyrimidinones/*chemistry
Triazoles/*chemistry
Adaptor Proteins, Signal Transducing/chemistry ; High-Throughput Screening Assays ; Humans ; Phosphoproteins/chemistry ; Phosphorylation ; Protein-Serine-Threonine Kinases/chemistry
Czasopismo naukowe
Tytuł :
Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease.
Autorzy :
Liu W; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang 110840, People's Republic of China.
Liu X; School of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang 110840, People's Republic of China.
Tian L; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang 110840, People's Republic of China.
Gao Y; School of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang 110840, People's Republic of China.
Liu W; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang 110840, People's Republic of China.
Chen H; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang 110840, People's Republic of China.
Jiang X; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang 110840, People's Republic of China.
Xu Z; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang 110840, People's Republic of China.
Ding H; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address: .
Zhao Q; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang 110840, People's Republic of China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113554. Date of Electronic Publication: 2021 May 29.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*drug therapy
Glycogen Synthase Kinase 3 beta/*antagonists & inhibitors
Harmine/*pharmacology
Neuroprotective Agents/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Protein-Serine-Threonine Kinases/*antagonists & inhibitors
Protein-Tyrosine Kinases/*antagonists & inhibitors
Alzheimer Disease/metabolism ; Cell Line ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Design ; Glycogen Synthase Kinase 3 beta/metabolism ; Harmine/chemical synthesis ; Harmine/chemistry ; Humans ; Models, Molecular ; Molecular Structure ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Protein-Serine-Threonine Kinases/metabolism ; Protein-Tyrosine Kinases/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
The CRL4VPRBP(DCAF1) E3 ubiquitin ligase directs constitutive RAG1 degradation in a non-lymphoid cell line.
Autorzy :
Schabla NM; Department of Medical Microbiology and Immunology, Creighton University, Omaha, Nebraska, United States of America.
Swanson PC; Department of Medical Microbiology and Immunology, Creighton University, Omaha, Nebraska, United States of America.
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Źródło :
PloS one [PLoS One] 2021 Oct 14; Vol. 16 (10), pp. e0258683. Date of Electronic Publication: 2021 Oct 14 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Homeodomain Proteins/*chemistry
Homeodomain Proteins/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Animals ; B-Lymphocytes/immunology ; Cell Line ; HEK293 Cells ; Homeodomain Proteins/genetics ; Humans ; Immunoglobulin Light Chains/metabolism ; Mice ; Protein-Serine-Threonine Kinases/genetics ; Proteolysis ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/genetics ; V(D)J Recombination
Czasopismo naukowe
Tytuł :
Spatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platforms.
Autorzy :
Lee HS; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea. .
Min S; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea.
Jung YE; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.
Chae S; Institute of Medical Science, Ajou University School of Medicine, Suwon, 16499, Korea.
Heo J; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea.; Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, 16499, Korea.
Lee JH; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea.; Institute of Medical Science, Ajou University School of Medicine, Suwon, 16499, Korea.
Kim T; Department of Life Science, Ewha Womans University, Seoul, 03760, Korea.
Kang HC; Department of Physiology, Ajou University School of Medicine, Suwon, Korea.
Nakanish M; Division of Cancer Cell Biology, The University of Tokyo, Tokyo, 108-8639, Japan.
Cha SS; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.
Cho H; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 11; Vol. 12 (1), pp. 5931. Date of Electronic Publication: 2021 Oct 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosome Segregation*
Mitosis*
Aurora Kinase B/*genetics
Cell Cycle Proteins/*genetics
Nuclear Proteins/*genetics
Protein-Serine-Threonine Kinases/*genetics
Proto-Oncogene Proteins/*genetics
Signal Transduction/*genetics
Trans-Activators/*genetics
Aspartic Acid/metabolism ; Aurora Kinase B/metabolism ; Cell Cycle Proteins/metabolism ; Chromatin/chemistry ; Chromatin/metabolism ; Feedback, Physiological ; Gene Expression Regulation ; HeLa Cells ; Histones/genetics ; Histones/metabolism ; Humans ; Kinetochores/metabolism ; Kinetochores/ultrastructure ; Microtubules/metabolism ; Microtubules/ultrastructure ; Nuclear Proteins/deficiency ; Phosphorylation ; Protein-Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/metabolism ; Serine/metabolism ; Trans-Activators/deficiency
Czasopismo naukowe
Tytuł :
OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice.
Autorzy :
Schünke H; Institute for Genetics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Göbel U; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Dikic I; Institute of Biochemistry II, Goethe-Universität Frankfurt am Main, Buchmann Institute for Molecular Life Sciences, Frankfurt, Germany.
Pasparakis M; Institute for Genetics, University of Cologne, Cologne, Germany. .; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. .; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 08; Vol. 12 (1), pp. 5912. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dermatitis/*prevention & control
Endopeptidases/*metabolism
Endopeptidases/*pharmacology
Keratinocytes/*metabolism
Necroptosis/*drug effects
Receptor-Interacting Protein Serine-Threonine Kinases/*metabolism
Animals ; Apoptosis ; Cell Death ; Dermatitis/pathology ; Endopeptidases/genetics ; Epidermis/metabolism ; Female ; Homeostasis ; Inflammation ; Keratinocytes/drug effects ; Male ; Mice ; Mice, Knockout ; Receptor-Interacting Protein Serine-Threonine Kinases/genetics ; Receptors, Tumor Necrosis Factor, Type I ; Signal Transduction ; Skin/pathology ; Transcriptome
Czasopismo naukowe
Tytuł :
DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks.
Autorzy :
Aricthota S; Laboratory of Chromatin Biology and Epigenetics, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.; Graduate Studies, Manipal Academy of Higher Education, Manipal, India.
Haldar D; Laboratory of Chromatin Biology and Epigenetics, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.
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Źródło :
ELife [Elife] 2021 Oct 05; Vol. 10. Date of Electronic Publication: 2021 Oct 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*genetics
Histone Deacetylases/*genetics
Protein-Serine-Threonine Kinases/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Schizosaccharomyces/*genetics
Schizosaccharomyces pombe Proteins/*genetics
Cell Cycle Proteins/metabolism ; DNA Replication ; Histone Deacetylases/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/metabolism
Czasopismo naukowe

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