Temat: "Protein-Serine-Threonine Kinases" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Leveraging the Fragment Molecular Orbital Method to Explore the PLK1 Kinase Binding Site and Polo-Box Domain for Potent Small-Molecule Drug Design.
Autorzy:: Jin H; The Interdisciplinary Graduate Program in Integrative Biotechnology & Translational Medicine, Yonsei University, Incheon 21983, Republic of Korea.
Kim J; Department of Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.; Bioinformatics and Molecular Design Research Center (BMDRC), Incheon 21983, Republic of Korea.
Lee O; The Interdisciplinary Graduate Program in Integrative Biotechnology & Translational Medicine, Yonsei University, Incheon 21983, Republic of Korea.
Kim H; Bioinformatics and Molecular Design Research Center (BMDRC), Incheon 21983, Republic of Korea.
No KT; The Interdisciplinary Graduate Program in Integrative Biotechnology & Translational Medicine, Yonsei University, Incheon 21983, Republic of Korea.; Department of Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.; Bioinformatics and Molecular Design Research Center (BMDRC), Incheon 21983, Republic of Korea.; Baobab AiBIO Co., Ltd., Incheon 21983, Republic of Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 27; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 27.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Cycle Proteins*/metabolism
Protein Serine-Threonine Kinases*/metabolism
Binding Sites ; Drug Design ; Protein Kinase Inhibitors/chemistry ; Polo-Like Kinase 1

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 2.

Tytuł:: Genetic enhancers of partial PLK1 inhibition reveal hypersensitivity to kinetochore perturbations.
Autorzy:: Normandin K; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada.
Coulombe-Huntington J; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada.
St-Denis C; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada.
Bernard A; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada.
Bourouh M; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada.
Bertomeu T; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada.
Tyers M; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada.; Département de médecine, Université de Montréal, Montréal, Canada.
Archambault V; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada.; Département de biochimie et médecine moléculaire, Université de Montréal, Montréal, Canada.; Pokaż więcej
Źródło:: PLoS genetics [PLoS Genet] 2023 Aug 28; Vol. 19 (8), pp. e1010903. Date of Electronic Publication: 2023 Aug 28 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Cycle Proteins*/genetics
Kinetochores*
Protein Serine-Threonine Kinases*/genetics
Enhancer Elements, Genetic*
Humans ; Polo-Like Kinase 1

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 3.

Tytuł:: Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells.
Autorzy:: Yang X; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Smith JL; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Beck MT; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53719, USA.
Wilkinson JM; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53719, USA.
Michaud A; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53719, USA.
Vasta JD; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53719, USA.
Robers MB; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53719, USA.
Willson TM; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Mar 25; Vol. 28 (7). Date of Electronic Publication: 2023 Mar 25.
Typ publikacji:: Journal Article
MeSH Terms:: Protein Serine-Threonine Kinases*
Cell Cycle Proteins*/metabolism
Protein Kinases ; Cell Proliferation ; Mitosis ; Protein Kinase Inhibitors/pharmacology

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 4.

Tytuł:: Multiple Roles of PLK1 in Mitosis and Meiosis.
Autorzy:: Kalous J; Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 277 21 Libechov, Czech Republic.
Aleshkina D; Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 277 21 Libechov, Czech Republic.; Pokaż więcej
Źródło:: Cells [Cells] 2023 Jan 02; Vol. 12 (1). Date of Electronic Publication: 2023 Jan 02.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:: Protein Serine-Threonine Kinases*/metabolism
Cell Cycle Proteins*/metabolism
Female ; Humans ; Proto-Oncogene Proteins/metabolism ; Meiosis ; Mitosis ; Polo-Like Kinase 1

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 5.

Tytuł:: Selective role of the DNA helicase Mcm5 in BMP retrograde signaling during Drosophila neuronal differentiation.
Autorzy:: Rubio-Ferrera I; Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.
Baladrón-de-Juan P; Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.
Clarembaux-Badell L; Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.
Truchado-Garcia M; University of California Berkeley, Berkeley, California, United States of America.
Jordán-Álvarez S; Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.
Thor S; School of Biomedical Sciences, The University of Queensland, Brisbane, Australia.
Benito-Sipos J; Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.
Monedero Cobeta I; Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.; Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.; Pokaż więcej
Źródło:: PLoS genetics [PLoS Genet] 2022 Jun 23; Vol. 18 (6), pp. e1010255. Date of Electronic Publication: 2022 Jun 23 (Print Publication: 2022).
Typ publikacji:: Journal Article
MeSH Terms:: Bone Morphogenetic Proteins*/genetics
Bone Morphogenetic Proteins*/metabolism
Cell Cycle Proteins*/genetics
Cell Cycle Proteins*/metabolism
Drosophila Proteins*/genetics
Drosophila Proteins*/metabolism
Neurons*/cytology
Neurons*/metabolism
Protein Serine-Threonine Kinases*/genetics
Protein Serine-Threonine Kinases*/metabolism
Receptors, Cell Surface*/genetics
Receptors, Cell Surface*/metabolism
Animals ; DNA Replication/genetics ; Drosophila melanogaster ; Mice ; Minichromosome Maintenance Proteins/genetics ; Signal Transduction

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 6.

Tytuł:: N(6)-methyladenosine methylation-regulated polo-like kinase 1 cell cycle homeostasis as a potential target of radiotherapy in pancreatic adenocarcinoma.
Autorzy:: Tatekawa S; Department of Radiation Oncology, Osaka University Graduate School of Medicine, Yamadaoka 2-2, Suita, Osaka, 565-0871, Japan.
Tamari K; Department of Radiation Oncology, Osaka University Graduate School of Medicine, Yamadaoka 2-2, Suita, Osaka, 565-0871, Japan.
Chijimatsu R; Department of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Yamadaoka 2-2, Suita, Osaka, 565-0871, Japan.
Konno M; Department of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Yamadaoka 2-2, Suita, Osaka, 565-0871, Japan.; Division of Tumor Biology, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science, Noda, Chiba, Japan.
Motooka D; Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, 565-0871, Japan.
Mitsufuji S; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan.
Akita H; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan.
Kobayashi S; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan.
Murakumo Y; Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa, 252-0374, Japan.
Doki Y; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan.
Eguchi H; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan.
Ishii H; Department of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Yamadaoka 2-2, Suita, Osaka, 565-0871, Japan. .
Ogawa K; Department of Radiation Oncology, Osaka University Graduate School of Medicine, Yamadaoka 2-2, Suita, Osaka, 565-0871, Japan. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Jun 30; Vol. 12 (1), pp. 11074. Date of Electronic Publication: 2022 Jun 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Adenocarcinoma*/genetics
Adenocarcinoma*/radiotherapy
Adenosine*/analogs & derivatives
Adenosine*/metabolism
Cell Cycle Proteins*/metabolism
Pancreatic Neoplasms*/drug therapy
Pancreatic Neoplasms*/genetics
Pancreatic Neoplasms*/radiotherapy
Protein Serine-Threonine Kinases*/metabolism
Proto-Oncogene Proteins*/metabolism
Cell Cycle/genetics ; Homeostasis ; Humans ; Methylation ; Methyltransferases/metabolism ; RNA-Binding Proteins/metabolism ; Polo-Like Kinase 1 ; Pancreatic Neoplasms

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 7.

Tytuł:: Clinicopathological Significance of AKT1 and PLK1 Expression in Oral Squamous Cell Carcinoma.
Autorzy:: Sun EC; Department of Stomatology, Shihezi University School of Medicine & the First Affiliated Hospital to Shihezi University School of Medicine, Shihezi, 832002 Xinjiang, China.
Dong SS; Department of Pathology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu 225000, China.
Li ZJ; Department of Stomatology, Shihezi University School of Medicine & the First Affiliated Hospital to Shihezi University School of Medicine, Shihezi, 832002 Xinjiang, China.
Li CX; Department of Stomatology, Shihezi University School of Medicine & the First Affiliated Hospital to Shihezi University School of Medicine, Shihezi, 832002 Xinjiang, China.; Pokaż więcej
Źródło:: Disease markers [Dis Markers] 2022 Jun 17; Vol. 2022, pp. 7300593. Date of Electronic Publication: 2022 Jun 17 (Print Publication: 2022).
Typ publikacji:: Journal Article
MeSH Terms:: Cell Cycle Proteins*/biosynthesis
Mouth Neoplasms*/metabolism
Protein Serine-Threonine Kinases*/biosynthesis
Proto-Oncogene Proteins*/biosynthesis
Proto-Oncogene Proteins c-akt*
Squamous Cell Carcinoma of Head and Neck*/metabolism
Biomarkers, Tumor/metabolism ; Humans ; Prognosis ; Polo-Like Kinase 1

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 8.

Tytuł:: Ste20-like kinase activity promotes meiotic resumption and spindle microtubule stability in mouse oocytes.
Autorzy:: Song K; Department of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Jiang X; Division of Sport Anatomy, School of Sport Science, Beijing Sport University, Beijing, China.
Xu X; Department of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Chen Y; Department of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Zhang J; Department of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Tian Y; Department of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Wang Q; Department of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Weng J; Department of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Liang Y; Department of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Ma W; Department of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.; Pokaż więcej
Źródło:: Cell proliferation [Cell Prolif] 2023 Apr; Vol. 56 (4), pp. e13391. Date of Electronic Publication: 2022 Dec 29.
Typ publikacji:: Journal Article
MeSH Terms:: Oocytes*/metabolism
Cell Cycle Proteins*/metabolism
Animals ; Mice ; RNA, Complementary/metabolism ; Meiosis ; Microtubules/metabolism ; Spindle Apparatus/metabolism ; Protein Serine-Threonine Kinases/metabolism

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 9.

Tytuł:: Deletion of TRIB3 disrupts the tumor progression induced by integrin αvβ3 in lung cancer.
Autorzy:: Zhou W; Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin City, 300052, China.; Department of Thoracic Surgery, Shanxi Provincial People's Hospital, Taiyuan, China.
Ma J; Department of Thoracic Surgery, Shanxi Provincial People's Hospital, Taiyuan, China.
Meng L; Department of Thoracic Surgery, Shanxi Provincial People's Hospital, Taiyuan, China.
Liu D; Department of Thoracic Surgery, Shanxi Provincial People's Hospital, Taiyuan, China.
Chen J; Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin City, 300052, China. .; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2022 Apr 26; Vol. 22 (1), pp. 459. Date of Electronic Publication: 2022 Apr 26.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Cycle Proteins*/genetics
Cell Cycle Proteins*/metabolism
Integrin alphaVbeta3*/genetics
Integrin alphaVbeta3*/metabolism
Lung Neoplasms*/pathology
Protein Serine-Threonine Kinases*/antagonists & inhibitors
Protein Serine-Threonine Kinases*/genetics
Protein Serine-Threonine Kinases*/metabolism
Repressor Proteins*/genetics
Repressor Proteins*/metabolism
Animals ; Cell Proliferation/genetics ; Humans ; Mice ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 10.

Tytuł:: Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.
Autorzy:: Papenfuss M; Institute of Pharmacology and Toxicology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.
Lützow S; Institute of Pharmacology and Toxicology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.
Wilms G; Institute of Pharmacology and Toxicology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.
Babendreyer A; Institute of Molecular Pharmacology, RWTH Aachen University, 52074, Aachen, Germany.
Flaßhoff M; Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, 38106, Braunschweig, Germany.
Kunick C; Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, 38106, Braunschweig, Germany.
Becker W; Institute of Pharmacology and Toxicology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Feb 14; Vol. 12 (1), pp. 2393. Date of Electronic Publication: 2022 Feb 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Cycle Proteins/*metabolism
Chaperonins/*metabolism
HSP90 Heat-Shock Proteins/*metabolism
Protein Serine-Threonine Kinases/*metabolism
Protein-Tyrosine Kinases/*metabolism
Animals ; Catalytic Domain ; Cell Cycle Proteins/genetics ; Chaperonins/genetics ; HSP90 Heat-Shock Proteins/genetics ; Humans ; Phosphorylation ; Protein Domains ; Protein Folding ; Protein Kinases/chemistry ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Protein Serine-Threonine Kinases/chemistry ; Protein Serine-Threonine Kinases/genetics ; Protein-Tyrosine Kinases/chemistry ; Protein-Tyrosine Kinases/genetics ; Xenopus/genetics ; Xenopus/metabolism ; Xenopus Proteins/chemistry ; Xenopus Proteins/genetics ; Xenopus Proteins/metabolism ; Zebrafish/genetics ; Zebrafish/metabolism ; Zebrafish Proteins/chemistry ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism ; Dyrk Kinases

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 11.

Tytuł:: Sima, a Drosophila homolog of HIF-1α, in fat body tissue inhibits larval body growth by inducing Tribbles gene expression.
Autorzy:: Noguchi K; Department of Life Sciences and Medical BioScience, Waseda University School of Advanced Science and Engineering, Tokyo, Japan.
Yokozeki K; Department of Life Sciences and Medical BioScience, Waseda University School of Advanced Science and Engineering, Tokyo, Japan.
Tanaka Y; Department of Life Sciences and Medical BioScience, Waseda University School of Advanced Science and Engineering, Tokyo, Japan.
Suzuki Y; Department of Life Sciences and Medical BioScience, Waseda University School of Advanced Science and Engineering, Tokyo, Japan.
Nakajima K; Department of Life Sciences and Medical BioScience, Waseda University School of Advanced Science and Engineering, Tokyo, Japan.
Nishimura T; Laboratory of Metabolic Regulation and Genetics, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan.
Goda N; Department of Life Sciences and Medical BioScience, Waseda University School of Advanced Science and Engineering, Tokyo, Japan.; Pokaż więcej
Źródło:: Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2022 Feb; Vol. 27 (2), pp. 145-151. Date of Electronic Publication: 2021 Dec 27.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Cycle Proteins*/genetics
Cell Cycle Proteins*/metabolism
DNA-Binding Proteins*/genetics
DNA-Binding Proteins*/metabolism
Drosophila*/genetics
Drosophila*/growth & development
Drosophila Proteins*/genetics
Drosophila Proteins*/metabolism
Protein Serine-Threonine Kinases*/genetics
Protein Serine-Threonine Kinases*/metabolism
Animals ; Fat Body/metabolism ; Gene Expression ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Larva/growth & development

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 12.

Tytuł:: BUBs Are New Biomarkers of Promoting Tumorigenesis and Affecting Prognosis in Breast Cancer.
Autorzy:: Wang S; Department of Thyroid and Breast Surgery, Tianjin Fourth Central Hospital, Tianjin 300140, China.; The Fourth Central Clinical School, Tianjin Medical University, Tianjin 300140, China.
Liu X; Department of Thyroid and Breast Surgery, Tianjin Fourth Central Hospital, Tianjin 300140, China.; The Fourth Central Clinical School, Tianjin Medical University, Tianjin 300140, China.
Yang M; Department of Thyroid and Breast Surgery, Tianjin Fourth Central Hospital, Tianjin 300140, China.; The Fourth Central Clinical School, Tianjin Medical University, Tianjin 300140, China.
Yuan D; The Fourth Central Clinical School, Tianjin Medical University, Tianjin 300140, China.
Ye K; Department of Vascular Surgery, Tianjin Fourth Central Hospital, Tianjin 300140, China.
Qu X; Department of Thyroid and Breast Surgery, Tianjin Fourth Central Hospital, Tianjin 300140, China.
Wang X; Department of Thyroid and Breast Surgery, Tianjin Fourth Central Hospital, Tianjin 300140, China.; The Fourth Central Clinical School, Tianjin Medical University, Tianjin 300140, China.; Pokaż więcej
Źródło:: Disease markers [Dis Markers] 2022 Apr 21; Vol. 2022, pp. 2760432. Date of Electronic Publication: 2022 Apr 21 (Print Publication: 2022).
Typ publikacji:: Journal Article
MeSH Terms:: Breast Neoplasms*/genetics
Cell Cycle Proteins/*metabolism
Poly-ADP-Ribose Binding Proteins/*metabolism
Protein Serine-Threonine Kinases/*metabolism
Benzimidazoles ; Biomarkers ; Carcinogenesis ; Cell Cycle Proteins/genetics ; Cell Transformation, Neoplastic ; Female ; Humans ; Prognosis ; Protein Serine-Threonine Kinases/genetics

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 13.

Tytuł:: Pharmacological Activation of YAP/TAZ by Targeting LATS1/2 Enhances Periodontal Tissue Regeneration in a Murine Model.
Autorzy:: Sato A; Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Suzuki S; Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Yuan H; Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Fahreza RR; Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Wang X; Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Nemoto E; Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Saito M; Department of Restorative Dentistry, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.
Yamada S; Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Jan 04; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 04.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Cycle Proteins*/genetics
Cell Cycle Proteins*/metabolism
Adaptor Proteins, Signal Transducing*/metabolism
Mice ; Animals ; Disease Models, Animal ; Transcription Factors/genetics ; Transcription Factors/metabolism ; YAP-Signaling Proteins ; Protein Serine-Threonine Kinases/metabolism

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 14.

Tytuł:: Tanshinone IIA suppresses the progression of lung adenocarcinoma through regulating CCNA2-CDK2 complex and AURKA/PLK1 pathway.
Autorzy:: Li Z; Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Zhang Y; Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Zhou Y; Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Wang F; Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Yin C; Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Ding L; Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China. .
Zhang S; Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Dec 08; Vol. 11 (1), pp. 23681. Date of Electronic Publication: 2021 Dec 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Abietanes/*pharmacology
Adenocarcinoma of Lung/*metabolism
Antineoplastic Agents, Phytogenic/*pharmacology
Aurora Kinase A/*metabolism
Cell Cycle Proteins/*metabolism
Cyclin A2/*metabolism
Cyclin-Dependent Kinase 2/*metabolism
Protein Serine-Threonine Kinases/*metabolism
Proto-Oncogene Proteins/*metabolism
Abietanes/chemistry ; Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/etiology ; Adenocarcinoma of Lung/pathology ; Antineoplastic Agents, Phytogenic/chemistry ; Apoptosis/drug effects ; Aurora Kinase A/chemistry ; Biomarkers, Tumor ; Cell Cycle/drug effects ; Cell Cycle Proteins/chemistry ; Cell Line, Tumor ; Computational Biology/methods ; Cyclin A2/chemistry ; Cyclin-Dependent Kinase 2/chemistry ; Disease Susceptibility ; Gene Expression Profiling ; Humans ; Models, Molecular ; Protein Interaction Mapping ; Protein Interaction Maps ; Protein Serine-Threonine Kinases/chemistry ; Proto-Oncogene Proteins/chemistry ; Signal Transduction/drug effects ; Structure-Activity Relationship ; Transcriptome ; Polo-Like Kinase 1

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 15.

Tytuł:: Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP/PS1 transgenic mice.
Autorzy:: Cao LL; College of Life and Health Sciences, Northeastern University, No. 3-11. Wenhua Road, Shenyang, 110819, People's Republic of China.
Guan PP; College of Life and Health Sciences, Northeastern University, No. 3-11. Wenhua Road, Shenyang, 110819, People's Republic of China.
Zhang SQ; College of Life and Health Sciences, Northeastern University, No. 3-11. Wenhua Road, Shenyang, 110819, People's Republic of China.
Yang Y; College of Life and Health Sciences, Northeastern University, No. 3-11. Wenhua Road, Shenyang, 110819, People's Republic of China.
Huang XS; College of Life and Health Sciences, Northeastern University, No. 3-11. Wenhua Road, Shenyang, 110819, People's Republic of China. .
Wang P; College of Life and Health Sciences, Northeastern University, No. 3-11. Wenhua Road, Shenyang, 110819, People's Republic of China. .; Pokaż więcej
Źródło:: Journal of neuroinflammation [J Neuroinflammation] 2021 Dec 03; Vol. 18 (1), pp. 281. Date of Electronic Publication: 2021 Dec 03.
Typ publikacji:: Journal Article
MeSH Terms:: Alzheimer Disease/*metabolism
Cell Cycle Proteins/*metabolism
DNA-Binding Proteins/*metabolism
Inflammasomes/*metabolism
Membrane Transport Proteins/*metabolism
Neuroinflammatory Diseases/*metabolism
Receptor-Interacting Protein Serine-Threonine Kinases/*metabolism
Animals ; Apoptosis/physiology ; Brain/metabolism ; Caspase 1/metabolism ; Cell Cycle Proteins/genetics ; Cell Line ; DNA-Binding Proteins/genetics ; Humans ; Interleukin-1beta/metabolism ; Membrane Transport Proteins/genetics ; Mice ; Mice, Transgenic ; Neuroinflammatory Diseases/genetics ; Receptor-Interacting Protein Serine-Threonine Kinases/genetics

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 16.

Tytuł:: TRIB3 regulates FSHR expression in human granulosa cells under high levels of free fatty acids.
Autorzy:: Wang N; Department of Gynecology and Obstetrics, Ruijin Hospital Affiliated with the Medical School of Shanghai Jiao Tong University, Shanghai, 200025, China.
Si C; Department of Gynecology and Obstetrics, Ruijin Hospital Affiliated with the Medical School of Shanghai Jiao Tong University, Shanghai, 200025, China.
Xia L; Department of Gynecology and Obstetrics, Ruijin Hospital Affiliated with the Medical School of Shanghai Jiao Tong University, Shanghai, 200025, China.
Wu X; Department of Gynecology and Obstetrics, Ruijin Hospital Affiliated with the Medical School of Shanghai Jiao Tong University, Shanghai, 200025, China.
Zhao S; Department of Gynecology and Obstetrics, Ruijin Hospital Affiliated with the Medical School of Shanghai Jiao Tong University, Shanghai, 200025, China.
Xu H; Department of Gynecology and Obstetrics, Ruijin Hospital Affiliated with the Medical School of Shanghai Jiao Tong University, Shanghai, 200025, China.
Ding Z; Department of Histology, Embryology, Genetics and Developmental Biology, Shanghai Key Laboratory for Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. .
Niu Z; Department of Gynecology and Obstetrics, Ruijin Hospital Affiliated with the Medical School of Shanghai Jiao Tong University, Shanghai, 200025, China. .; Pokaż więcej
Źródło:: Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2021 Sep 09; Vol. 19 (1), pp. 139. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Expression Regulation*
Cell Cycle Proteins/*genetics
Fatty Acids, Nonesterified/*metabolism
Granulosa Cells/*metabolism
Protein Serine-Threonine Kinases/*antagonists & inhibitors
Receptors, FSH/*genetics
Repressor Proteins/*genetics
Activating Transcription Factor 4/genetics ; Activating Transcription Factor 4/metabolism ; Adult ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cells, Cultured ; Estradiol/metabolism ; Female ; Fertilization in Vitro/methods ; Glycogen Synthase Kinase 3 beta/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Infertility, Female/genetics ; Infertility, Female/metabolism ; Infertility, Female/therapy ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; RNA Interference ; Receptors, FSH/metabolism ; Repressor Proteins/metabolism ; Signal Transduction/genetics

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 17.

Tytuł:: TRIB3 Modulates PPARγ-Mediated Growth Inhibition by Interfering with the MLL Complex in Breast Cancer Cells.
Autorzy:: Hernández-Quiles M; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3584 Utrecht, CG, The Netherlands.
Baak R; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3584 Utrecht, CG, The Netherlands.
Orea-Soufi A; Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, 28040 Madrid, Spain.; Instituto de Investigaciones Sanitarias San Carlos (IdISSC), 28040 Madrid, Spain.
Borgman A; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3584 Utrecht, CG, The Netherlands.
den Haan S; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3584 Utrecht, CG, The Netherlands.
Sobrevals Alcaraz P; Oncode Institute and Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3584 Utrecht, CG, The Netherlands.
Jongejan A; Department of Bioinformatics, Amsterdam UMC Location University of Amsterdam, 1105 Amsterdam, AZ, The Netherlands.
van Es R; Oncode Institute and Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3584 Utrecht, CG, The Netherlands.
Velasco G; Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, 28040 Madrid, Spain.; Instituto de Investigaciones Sanitarias San Carlos (IdISSC), 28040 Madrid, Spain.
Vos H; Oncode Institute and Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3584 Utrecht, CG, The Netherlands.
Kalkhoven E; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3584 Utrecht, CG, The Netherlands.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Sep 11; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 11.
Typ publikacji:: Journal Article
MeSH Terms:: Breast Neoplasms*/genetics
Cell Cycle Proteins*/metabolism
Female ; Humans ; Ligands ; PPAR gamma/genetics ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein Serine-Threonine Kinases/genetics ; RNA, Messenger/genetics ; Repressor Proteins/genetics ; Transcription Factors

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 18.

Tytuł:: Effects of Aurora kinase A on mouse decidualization via Stat3-plk1-cdk1 pathway.
Autorzy:: Wang PC; College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, China.; College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Chen ST; College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Yang ZM; College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. .; Pokaż więcej
Źródło:: Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2021 Oct 29; Vol. 19 (1), pp. 162. Date of Electronic Publication: 2021 Oct 29.
Typ publikacji:: Journal Article
MeSH Terms:: Aurora Kinase A/*biosynthesis
CDC2 Protein Kinase/*metabolism
Cell Cycle Proteins/*metabolism
Decidua/*metabolism
Protein Serine-Threonine Kinases/*metabolism
Proto-Oncogene Proteins/*metabolism
STAT3 Transcription Factor/*metabolism
Signal Transduction/*physiology
Animals ; Aurora Kinase A/antagonists & inhibitors ; CDC2 Protein Kinase/antagonists & inhibitors ; Cell Cycle Proteins/antagonists & inhibitors ; Cells, Cultured ; Decidua/drug effects ; Enzyme Inhibitors/pharmacology ; Female ; Mice ; Pregnancy ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Proto-Oncogene Proteins/antagonists & inhibitors ; STAT3 Transcription Factor/antagonists & inhibitors ; Signal Transduction/drug effects ; Polo-Like Kinase 1

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 19.

Tytuł:: Loss of BubR1 acetylation provokes replication stress and leads to complex chromosomal rearrangements.
Autorzy:: Park J; Department of Biological Sciences & Institute of Molecular Biology and Genetics, Seoul National University, Korea.
Yeu SY; Department of Biological Sciences & Institute of Molecular Biology and Genetics, Seoul National University, Korea.
Paik S; Department of Biological Sciences & Institute of Molecular Biology and Genetics, Seoul National University, Korea.
Kim H; Department of Biological Sciences & Institute of Molecular Biology and Genetics, Seoul National University, Korea.
Choi SY; Department of Biological Sciences & Institute of Molecular Biology and Genetics, Seoul National University, Korea.
Lee J; Department of Biological Sciences & Institute of Molecular Biology and Genetics, Seoul National University, Korea.
Jang J; Department of Bioengineering, School of Life Sciences, Ulsan National Institute of Science and Technology, Korea.
Lee S; Department of Bioengineering, School of Life Sciences, Ulsan National Institute of Science and Technology, Korea.
Koh Y; Department of Internal Medicine, Seoul National University Hospital, Korea.
Lee H; Department of Biological Sciences & Institute of Molecular Biology and Genetics, Seoul National University, Korea.; Pokaż więcej
Źródło:: The FEBS journal [FEBS J] 2021 Oct; Vol. 288 (20), pp. 5925-5942. Date of Electronic Publication: 2021 May 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Aneuploidy*
Chromosomal Instability*
Chromosome Segregation*
Carcinogenesis/*pathology
Cell Cycle Proteins/*physiology
Protein Serine-Threonine Kinases/*physiology
Telomere/*genetics
Tumor Suppressor Protein p53/*physiology
Acetylation ; Animals ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Cell Cycle Checkpoints ; Cell Cycle Proteins/chemistry ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Protein Serine-Threonine Kinases/chemistry

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 20.

Tytuł:: Studies of Interaction Mechanism between Pyrido [3,4- d ] Pyrimidine Inhibitors and Mps1.
Autorzy:: Xing C; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Zhou X; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Chen C; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Sun W; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Zheng Q; Laboratory of Theoretical and Computational Chemistry, Jilin University, Changchun 130023, China.
Liang D; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2021 Aug 21; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 21.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Cycle Proteins/*chemistry
Protein Kinase Inhibitors/*chemistry
Protein Serine-Threonine Kinases/*antagonists & inhibitors
Protein-Tyrosine Kinases/*antagonists & inhibitors
Pyrimidines/*chemistry
Catalytic Domain ; Cell Cycle Proteins/antagonists & inhibitors ; Crystallography, X-Ray ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Kinase Inhibitors/pharmacology ; Protein Serine-Threonine Kinases/chemistry ; Protein-Tyrosine Kinases/chemistry ; Pyrimidines/pharmacology

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Informacja

Wyszukujesz frazę ""Protein-Serine-Threonine Kinases"" wg kryterium: Temat

Źródło danych

Ogranicz do:

Ogranicz do bazy

Typ dokumentu

Temat

Wydawca

Publikacja

Język