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Wyszukujesz frazę ""Protein-Tyrosine Kinases"" wg kryterium: Temat


Tytuł:
Individualized targeted treatment in a case of a rare TFG::ROS1 fusion positive inflammatory myofibroblastic tumor (IMT).
Autorzy:
Sommer S; Department of Hematology and Oncology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Schmutz M; Department of Hematology and Oncology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Schaller T; General Pathology and Molecular Diagnostics, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Mayr P; Department of Hematology and Oncology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Dintner S; General Pathology and Molecular Diagnostics, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Märkl B; General Pathology and Molecular Diagnostics, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Huss R; General Pathology and Molecular Diagnostics, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Golas MM; Department of Hematology and Oncology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.; Human Genetics, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Kuhlen M; Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.; Swabian Children's Cancer Center, University Medical Center Augsburg, Augsburg, Germany.
Jordan F; Department of Hematology and Oncology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Claus R; General Pathology and Molecular Diagnostics, Faculty of Medicine, University of Augsburg, Augsburg, Germany.; Comprehensive Cancer Center Augsburg (CCCA), Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Heinrich B; Heinrich/Bangerter, Hämatologie-Onkologie im Zentrum MVZ, Augsburg, Germany.
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Źródło:
Cancer reports (Hoboken, N.J.) [Cancer Rep (Hoboken)] 2024 Jan; Vol. 7 (1), pp. e1916. Date of Electronic Publication: 2023 Nov 11.
Typ publikacji:
Case Reports
MeSH Terms:
Protein-Tyrosine Kinases*/genetics
Neoplasms*
Female ; Humans ; Adult ; Quality of Life ; Proto-Oncogene Proteins/genetics ; Precision Medicine ; Receptor Protein-Tyrosine Kinases/genetics ; Vesicular Transport Proteins
Raport
Tytuł:
Abdominal inflammatory myofibroblastic tumour: Clinicopathological and molecular analysis of 20 cases, highlighting potential therapeutic targets.
Autorzy:
Vernemmen AIP; Department of Pathology, School for Oncology and Reproduction (GROW), Maastricht University Medical Center, Maastricht, The Netherlands.
Samarska IV; Department of Pathology, School for Oncology and Reproduction (GROW), Maastricht University Medical Center, Maastricht, The Netherlands.
Speel EM; Department of Pathology, School for Oncology and Reproduction (GROW), Maastricht University Medical Center, Maastricht, The Netherlands.
Riedl RG; Department of Pathology, Zuyderland Medical Center, Geleen, The Netherlands.
Goudkade D; Department of Pathology, Zuyderland Medical Center, Geleen, The Netherlands.
de Bruïne AP; Department of Pathology, VieCuri Medical Center, Venlo, The Netherlands.
Wouda S; Department of Pathology, VieCuri Medical Center, Venlo, The Netherlands.
van Marion AM; Department of Pathology, VieCuri Medical Center, Venlo, The Netherlands.
Verlinden IV; Department of Pathology, Laurentius Hospital, Roermond, The Netherlands.
van Lijnschoten I; Department of Pathology, PAMM Laboratory for Pathology and Medical Microbiology, Eindhoven, The Netherlands.
Friederich P; Department of Gastroenterology and Hepatology, Catharina Hospital, Eindhoven, The Netherlands.
Winnepenninckx VJL; Department of Pathology, School for Oncology and Reproduction (GROW), Maastricht University Medical Center, Maastricht, The Netherlands.
Zur Hausen A; Department of Pathology, School for Oncology and Reproduction (GROW), Maastricht University Medical Center, Maastricht, The Netherlands.
Sciot RME; Department of Pathology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
van den Hout MFCM; Department of Pathology, School for Oncology and Reproduction (GROW), Maastricht University Medical Center, Maastricht, The Netherlands.
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Źródło:
Histopathology [Histopathology] 2024 Apr; Vol. 84 (5), pp. 794-809. Date of Electronic Publication: 2023 Dec 28.
Typ publikacji:
Journal Article
MeSH Terms:
Protein-Tyrosine Kinases*/genetics
Sarcoma*/genetics
Humans ; Anaplastic Lymphoma Kinase/genetics ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Proto-Oncogene Proteins/genetics ; Receptor Protein-Tyrosine Kinases/genetics
Czasopismo naukowe
Tytuł:
Effect of High-Fat Food on the Pharmacokinetic Profile and Safety of SAF-189s, an ALK/ROS1 Inhibitor, in Healthy Chinese Adults.
Autorzy:
Qin H; Department of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Tan Y; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Diao L; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Hui AM; EnCureGen Pharma, 9 Yayingshi Road, Huangpu District, Guangzhou, 510700, China.
Wu Z; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Zhou Y; Wanbang Biopharmaceuticals, 6 Yangshan Road, Economic Zone, Xuzhou, 221004, Jiangsu, China.
Sun J; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Xiang X; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Qiu J; Shanghai Fosun Pharmaceutical Development Co., Ltd., 1289 Yishan Road, Shanghai, 200233, China.
Hu W; Department of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China. .
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Źródło:
Drugs in R&D [Drugs R D] 2023 Dec; Vol. 23 (4), pp. 465-473. Date of Electronic Publication: 2023 Nov 07.
Typ publikacji:
Randomized Controlled Trial; Clinical Trial, Phase I; Journal Article
MeSH Terms:
East Asian People*
Protein-Tyrosine Kinases*/pharmacokinetics
Diet, High-Fat*
Adult ; Humans ; Administration, Oral ; Area Under Curve ; Biological Availability ; Cross-Over Studies ; Fasting ; Food-Drug Interactions ; Healthy Volunteers ; Proto-Oncogene Proteins ; Receptor Protein-Tyrosine Kinases
Czasopismo naukowe
Tytuł:
Molecular, clinicopathological characteristics and surgical results of resectable SMARCA4-deficient thoracic tumors.
Autorzy:
Luo J; Department of Thoracic Surgery, School of Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 West Huaihai Rd, Xuhui District, Shanghai, 200030, China.
Ding B; Department of Pathology, School of Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 West Huaihai Rd, Xuhui District, Shanghai, 200030, China.
Campisi A; Department of Thoracic Surgery, School of Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 West Huaihai Rd, Xuhui District, Shanghai, 200030, China.; Department of Thoracic Surgery, University and Hospital Trust-Ospedale Borgo Trento, piazzale aristide stefani 1, Verona, Italy.
Chen T; Department of Thoracic Surgery, School of Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 West Huaihai Rd, Xuhui District, Shanghai, 200030, China.
Teng H; Department of Pathology, School of Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 West Huaihai Rd, Xuhui District, Shanghai, 200030, China. .
Ji C; Department of Thoracic Surgery, School of Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 West Huaihai Rd, Xuhui District, Shanghai, 200030, China. .
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Źródło:
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2023 Jul; Vol. 149 (8), pp. 4455-4463. Date of Electronic Publication: 2022 Sep 19.
Typ publikacji:
Observational Study; Journal Article
MeSH Terms:
Protein-Tyrosine Kinases*
Thoracic Neoplasms*/genetics
Thoracic Neoplasms*/surgery
Thoracic Neoplasms*/pathology
Humans ; Proto-Oncogene Proteins ; Prognosis ; Receptor Protein-Tyrosine Kinases ; Biomarkers, Tumor/genetics ; DNA Helicases/genetics ; Nuclear Proteins/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł:
Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.
Autorzy:
Kan Y; Department of Physiology and Biophysics, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USA.
Paung Y; Department of Pharmacology, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USA.
Seeliger MA; Department of Pharmacology, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USA.
Miller WT; Department of Physiology and Biophysics, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USA.; Department of Veterans Affairs Medical Center, Northport, NY 11768-2200, USA.
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Źródło:
Cells [Cells] 2023 Mar 15; Vol. 12 (6). Date of Electronic Publication: 2023 Mar 15.
Typ publikacji:
Journal Article; Review; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
MeSH Terms:
ErbB Receptors*/metabolism
Protein-Tyrosine Kinases*/chemistry
Protein-Tyrosine Kinases*/metabolism
Protein-Tyrosine Kinases*/physiology
Protein Domains ; Receptor Protein-Tyrosine Kinases/metabolism ; src Homology Domains
Czasopismo naukowe
Tytuł:
Pterostilbene protects against H 2 O 2 -induced oxidative stress by regulating GAS6/Axl signaling in HL-1 cells.
Autorzy:
Di W; Department of Cardiovascular Medicine, National Clinical Research Center for Infectious Diseases, Shenzhen, China.
Zhao A; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China.
Li X; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China.
Chen J; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China.; Department of Cardiology, Affiliated Hospital, Yan'an University, Yan'an, China.
Dai Y; Department of Cardiovascular Medicine, National Clinical Research Center for Infectious Diseases, Shenzhen, China.
Li J; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China.
Lei W; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China.
Yang Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China.
Lu H; Department of Cardiovascular Medicine, National Clinical Research Center for Infectious Diseases, Shenzhen, China.
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Źródło:
Cell biochemistry and function [Cell Biochem Funct] 2024 Mar; Vol. 42 (2), pp. e3956.
Typ publikacji:
Journal Article
MeSH Terms:
Axl Receptor Tyrosine Kinase*
Receptor Protein-Tyrosine Kinases*/genetics
Receptor Protein-Tyrosine Kinases*/metabolism
Receptor Protein-Tyrosine Kinases*/pharmacology
Reactive Oxygen Species ; Proto-Oncogene Proteins/metabolism ; Molecular Docking Simulation ; Intercellular Signaling Peptides and Proteins/metabolism ; Signal Transduction ; Oxidative Stress ; Apoptosis
Czasopismo naukowe
Tytuł:
Receptor tyrosine kinase gene expression profiling of orbital rhabdomyosarcoma unveils MET as a potential biomarker and therapeutic target.
Autorzy:
Chauhan S; Ocular Pathology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, Room No. 725, New Delhi, 110029, India.
Sen S; Ocular Pathology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, Room No. 725, New Delhi, 110029, India. .
Irshad K; Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Kashyap S; Ocular Pathology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, Room No. 725, New Delhi, 110029, India.
Pushker N; Ophthalmoplasty Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
Meel R; Ophthalmoplasty Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
Sharma MC; Department of Pathology, All India Institute of Medical Sciences, New Delhi, 110029, India.
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Źródło:
Human cell [Hum Cell] 2024 Jan; Vol. 37 (1), pp. 297-309. Date of Electronic Publication: 2023 Nov 02.
Typ publikacji:
Journal Article
MeSH Terms:
Receptor Protein-Tyrosine Kinases*/genetics
Receptor Protein-Tyrosine Kinases*/metabolism
Rhabdomyosarcoma, Alveolar*/diagnosis
Rhabdomyosarcoma, Alveolar*/enzymology
Rhabdomyosarcoma, Alveolar*/pathology
Proto-Oncogene Proteins c-met*/genetics
Biomarkers, Tumor*/genetics
Gene Expression Regulation, Neoplastic*
Humans ; Drug Delivery Systems ; Survival Analysis ; Male ; Female ; Infant ; Child, Preschool ; Child ; Adolescent ; Multigene Family/genetics ; Principal Component Analysis ; Gene Expression Profiling
SCR Disease Name:
Rhabdomyosarcoma of the orbit
Czasopismo naukowe
Tytuł:
Somatic genomic landscape of East Asian epithelial ovarian carcinoma and its clinical implications from prospective clinical sequencing: A Korean Gynecologic Oncology Group study (KGOG 3047).
Autorzy:
Sa JK; BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, South Korea.
Kim J; Departments of Obstetrics and Gynecology, Chung-ang University Gwang-myeong Hospital, Gwang-myeong, South Korea.
Kang S; Gynecologic Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, South Korea.
Kim SW; Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Women's Cancer Center, Yonsei University College of Medicine, Seoul, South Korea.
Song T; Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Shim SH; Department of Obstetrics and Gynecology, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, South Korea.
Choi MC; Comprehensive Gynecologic Cancer Center, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
No JH; Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, South Korea.
Song JY; Department of Obstetrics and Gynecology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, South Korea.
Kim D; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Kim YM; Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, South Korea.
Kim JH; Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Lee JW; Departments of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.; Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University School of Medicine, Seoul, South Korea.
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Źródło:
International journal of cancer [Int J Cancer] 2022 Oct 01; Vol. 151 (7), pp. 1086-1097. Date of Electronic Publication: 2022 Jun 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/pathology
Protein-Tyrosine Kinases*/genetics
Carcinoma, Ovarian Epithelial/genetics ; Class I Phosphatidylinositol 3-Kinases/genetics ; Female ; Genomics ; Humans ; Mutation ; Prospective Studies ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins p21(ras)/genetics ; Receptor Protein-Tyrosine Kinases ; Republic of Korea/epidemiology
Czasopismo naukowe
Tytuł:
Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies.
Autorzy:
Robbins DW; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Noviski MA; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Tan YS; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Konst ZA; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Kelly A; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Auger P; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Brathaban N; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Cass R; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Chan ML; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Cherala G; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Clifton MC; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Gajewski S; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Ingallinera TG; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Karr D; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Kato D; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Ma J; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
McKinnell J; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
McIntosh J; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Mihalic J; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Murphy B; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Panga JR; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Peng G; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Powers J; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Perez L; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Rountree R; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Tenn-McClellan A; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Sands AT; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Weiss DR; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Wu J; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Ye J; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Guiducci C; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Hansen G; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
Cohen F; Nurix Therapeutics, Inc., 1700 Owens St., San Francisco, California 94158, United States.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2024 Feb 22; Vol. 67 (4), pp. 2321-2336. Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Protein-Tyrosine Kinases*
Protein Kinase Inhibitors*/adverse effects
Humans ; Agammaglobulinaemia Tyrosine Kinase ; Signal Transduction
Czasopismo naukowe
Tytuł:
The Wnt Co-Receptor PTK7/Otk and Its Homolog Otk-2 in Neurogenesis and Patterning.
Autorzy:
Tan QH; Division of Science, Yale-NUS College, Singapore 138527, Singapore.
Otgonbaatar A; Division of Science, Yale-NUS College, Singapore 138527, Singapore.
Kaur P; Division of Science, Yale-NUS College, Singapore 138527, Singapore.
Ga AF; Division of Science, Yale-NUS College, Singapore 138527, Singapore.
Harmston NP; Division of Science, Yale-NUS College, Singapore 138527, Singapore.; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 169857, Singapore.; Molecular Biosciences Division, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.
Tolwinski NS; Division of Science, Yale-NUS College, Singapore 138527, Singapore.; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 169857, Singapore.
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Źródło:
Cells [Cells] 2024 Feb 20; Vol. 13 (5). Date of Electronic Publication: 2024 Feb 20.
Typ publikacji:
Journal Article
MeSH Terms:
Neurogenesis*
Receptor Protein-Tyrosine Kinases*/metabolism
Wnt Signaling Pathway*/physiology
Body Patterning*
Animals ; Cell Differentiation ; Cell Membrane/metabolism
Czasopismo naukowe
Tytuł:
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
Autorzy:
Bashore FM; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Katis VL; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Du Y; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America.; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America.
Sikdar A; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Wang D; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America.; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America.
Bradshaw WJ; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Rygiel KA; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Leisner TM; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Chalk R; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Mishra S; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America.
Williams CA; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America.
Gileadi O; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Brennan PE; Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom.
Wiley JC; Sage Bionetworks, Seattle, WA, United States of America.
Gockley J; Sage Bionetworks, Seattle, WA, United States of America.
Cary GA; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, United States of America.
Carter GW; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, United States of America.
Young JE; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America.
Pearce KH; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Fu H; Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America.; Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America.
Axtman AD; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
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Corporate Authors:
Emory-Sage-SGC TREAT-AD Center
Źródło:
PloS one [PLoS One] 2024 Feb 15; Vol. 19 (2), pp. e0293548. Date of Electronic Publication: 2024 Feb 15 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
src Homology Domains*
Protein-Tyrosine Kinases*/metabolism
Humans ; Immunoreceptor Tyrosine-Based Activation Motif ; Intracellular Signaling Peptides and Proteins/metabolism ; Syk Kinase/metabolism ; Phosphorylation ; Receptors, Fc/metabolism ; Enzyme Precursors/metabolism
Czasopismo naukowe
Tytuł:
Differential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology through co-targeting PYK2.
Autorzy:
Liao Y; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Remsing Rix LL; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Li X; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Fang B; Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Izumi V; Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Welsh EA; Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Monastyrskyi A; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Department of Oncologic Sciences, University of South Florida, Tampa, FL 33620, USA.
Haura EB; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Koomen JM; Department of Oncologic Sciences, University of South Florida, Tampa, FL 33620, USA; Department of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Doebele RC; Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Rix U; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Department of Oncologic Sciences, University of South Florida, Tampa, FL 33620, USA. Electronic address: .
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Źródło:
Cell chemical biology [Cell Chem Biol] 2024 Feb 15; Vol. 31 (2), pp. 284-297.e10. Date of Electronic Publication: 2023 Oct 16.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Lactams*
Lung Neoplasms*/drug therapy
Protein-Tyrosine Kinases*/antagonists & inhibitors
Pyrazoles*
Humans ; Aminopyridines/pharmacology ; Anaplastic Lymphoma Kinase/genetics ; Focal Adhesion Kinase 2/antagonists & inhibitors ; Lactams, Macrocyclic ; Polypharmacology ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins
Czasopismo naukowe
Tytuł:
Larotrectinib versus infigratinib for adult patients with both glioma and tyrosine kinase alterations after failure of initial therapies: Efficacy and safety analysis.
Autorzy:
Chen Y; Department of Pathology, Changzhou Tumor Hospital, Changzhou, Jiangsu, China.
Ma J; Department of Oncology, Changzhou Tumor Hospital, Changzhou, Jiangsu, China.
Gao Q; Department of Pathology, Changzhou Tumor Hospital, Changzhou, Jiangsu, China.
Gai Y; Department of Pathology, Changzhou Tumor Hospital, Changzhou, Jiangsu, China.
Sun Y; Department of Pathology, Changzhou Tumor Hospital, Changzhou, Jiangsu, China.
Wang M; Department of Pathology, Changzhou Tumor Hospital, Changzhou, Jiangsu, China. Electronic address: .
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Źródło:
Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2024 Feb 07; Vol. 79, pp. 100329. Date of Electronic Publication: 2024 Feb 07 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Protein-Tyrosine Kinases*
Glioma*/drug therapy
Phenylurea Compounds*
Pyrazoles*
Pyrimidines*
Adult ; Humans ; Bevacizumab ; Disease Progression
Czasopismo naukowe
Tytuł:
Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2.
Autorzy:
Le Coadou L; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, F-75013, Paris, France.
Berthelet J; Université Paris Cité, CNRS, Unité Epigénétique et Destin Cellulaire, F-75013, Paris, France.
Mechaly AE; Institut Pasteur, Université Paris Cité, CNRS, Plateforme de Cristallographie-C2RT, F-75015, Paris, France.
Michail C; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, F-75013, Paris, France.
Bui LC; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, F-75013, Paris, France.
Dairou J; Université Paris cité, CNRS, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, F-75006, Paris, France.
Haouz A; Institut Pasteur, Université Paris Cité, CNRS, Plateforme de Cristallographie-C2RT, F-75015, Paris, France.
Dupret JM; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, F-75013, Paris, France.
Rodrigues Lima F; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, F-75013, Paris, France. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Feb 05; Vol. 695, pp. 149400. Date of Electronic Publication: 2023 Dec 21.
Typ publikacji:
Journal Article
MeSH Terms:
Protein-Tyrosine Kinases*/metabolism
Histones*/metabolism
Methylation ; Histone-Lysine N-Methyltransferase/genetics ; Protein Processing, Post-Translational
Czasopismo naukowe
Tytuł:
Prediction of ROS1 and TRKA/B/C occupancy in plasma and cerebrospinal fluid for entrectinib alone and in DDIs using physiologically based pharmacokinetic (PBPK) modeling approach.
Autorzy:
Chen L; 980 (Bethune International Peace) Hospital of PLA Joint Logistics Support Forces, Shijiazhuang, 050051, China.
Yao N; 980 (Bethune International Peace) Hospital of PLA Joint Logistics Support Forces, Shijiazhuang, 050051, China.
Yang H; 980 (Bethune International Peace) Hospital of PLA Joint Logistics Support Forces, Shijiazhuang, 050051, China.
Zhang S; Shijiazhuang Medical College, Shijiazhuang, 050599, China.
Zhang K; Department of Medical Oncology, Shijiazhuang People's Hospital, Shijiazhuang, 050051, China. .
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Źródło:
Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2024 Feb; Vol. 93 (2), pp. 107-119. Date of Electronic Publication: 2023 Oct 14.
Typ publikacji:
Journal Article
MeSH Terms:
Protein-Tyrosine Kinases*
Proto-Oncogene Proteins*
Benzamides*
Indazoles*
Humans ; Drug Interactions ; Itraconazole/pharmacokinetics ; Models, Biological
Czasopismo naukowe
Tytuł:
The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis.
Autorzy:
Korai A; Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan.
Lin X; Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan.
Tago K; Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, 3-39-22 Showa-Machi, Maebashi, Gunma 371-8514, Japan. Electronic address: .
Funakoshi-Tago M; Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan. Electronic address: .
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Źródło:
Cellular signalling [Cell Signal] 2024 Feb; Vol. 114, pp. 110985. Date of Electronic Publication: 2023 Nov 23.
Typ publikacji:
Journal Article
MeSH Terms:
Protein-Tyrosine Kinases*/metabolism
STAT3 Transcription Factor*/metabolism
Oncogene Proteins, Fusion*/metabolism
Animals ; Mice ; Acetylation ; Anaplastic Lymphoma Kinase/metabolism ; Cell Line, Tumor ; Cell Transformation, Neoplastic ; Mice, Nude ; Nucleophosmin/metabolism ; Humans
Czasopismo naukowe
Tytuł:
Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk.
Autorzy:
Lao-Peregrin C; Department of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA.
Xiang G; Department of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA; Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA.
Kim J; Department of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA.
Srivastava I; Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA.
Fall AB; Department of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA.
Gerhard DM; Department of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA.
Kohtala P; Department of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA.
Kim D; Department of Life Sciences, Yeongnam University, Gyeongsan, Gyeongbuk 38451, South Korea.
Song M; Department of Life Sciences, Yeongnam University, Gyeongsan, Gyeongbuk 38451, South Korea.
Garcia-Marcos M; Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
Levitz J; Department of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA; Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: .
Lee FS; Department of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2024 Jan 23; Vol. 43 (1), pp. 113595. Date of Electronic Publication: 2023 Dec 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Brain-Derived Neurotrophic Factor*
Receptor Protein-Tyrosine Kinases*
Signal Transduction/physiology ; Receptor, trkB/metabolism ; Receptors, G-Protein-Coupled ; Neuronal Plasticity/physiology
Czasopismo naukowe
Tytuł:
TrkB-mediated sustained neuroprotection is sex-specific and Erα-dependent in adult mice following neonatal hypoxia ischemia.
Autorzy:
Chanana V; Department of Pediatrics, University of Wisconsin-Madison, 1500 Highland Ave-T503, Madison, WI, 53705-9345, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Hackett M; Department of Pediatrics, University of Wisconsin-Madison, 1500 Highland Ave-T503, Madison, WI, 53705-9345, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Deveci N; Department of Pediatrics, University of Wisconsin-Madison, 1500 Highland Ave-T503, Madison, WI, 53705-9345, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Aycan N; Department of Pediatrics, University of Wisconsin-Madison, 1500 Highland Ave-T503, Madison, WI, 53705-9345, USA.
Ozaydin B; Department of Pediatrics, University of Wisconsin-Madison, 1500 Highland Ave-T503, Madison, WI, 53705-9345, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Cagatay NS; Department of Pediatrics, University of Wisconsin-Madison, 1500 Highland Ave-T503, Madison, WI, 53705-9345, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Hanalioglu D; Department of Pediatrics, University of Wisconsin-Madison, 1500 Highland Ave-T503, Madison, WI, 53705-9345, USA.
Kintner DB; Department of Pediatrics, University of Wisconsin-Madison, 1500 Highland Ave-T503, Madison, WI, 53705-9345, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Corcoran K; Department of Pediatrics, University of Wisconsin-Madison, 1500 Highland Ave-T503, Madison, WI, 53705-9345, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Yapici S; Department of Pediatrics, University of Wisconsin-Madison, 1500 Highland Ave-T503, Madison, WI, 53705-9345, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Camci F; Department of Pediatrics, University of Wisconsin-Madison, 1500 Highland Ave-T503, Madison, WI, 53705-9345, USA.
Eickhoff J; Department of Biostatistics & Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.
Frick KM; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Ferrazzano P; Department of Pediatrics, University of Wisconsin-Madison, 1500 Highland Ave-T503, Madison, WI, 53705-9345, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Levine JE; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA.
Cengiz P; Department of Pediatrics, University of Wisconsin-Madison, 1500 Highland Ave-T503, Madison, WI, 53705-9345, USA. .; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA. .
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Źródło:
Biology of sex differences [Biol Sex Differ] 2024 Jan 04; Vol. 15 (1), pp. 1. Date of Electronic Publication: 2024 Jan 04.
Typ publikacji:
Journal Article
MeSH Terms:
Receptor Protein-Tyrosine Kinases*/therapeutic use
Hypoxia-Ischemia, Brain*/drug therapy
Hypoxia-Ischemia, Brain*/metabolism
Animals ; Mice ; Male ; Female ; Neuroprotection ; Ischemia ; Hypoxia
Czasopismo naukowe
Tytuł:
Expression of NELL2/NICOL-ROS1 lumicrine signaling-related molecules in the human male reproductive tract.
Autorzy:
Kiyozumi D; Japan Science and Technology Agency, 7, Gobancho, Chiyoda-ku, Tokyo, 102-0076, Japan. .; Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan. .
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Źródło:
Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2024 Jan 02; Vol. 22 (1), pp. 3. Date of Electronic Publication: 2024 Jan 02.
Typ publikacji:
Journal Article
MeSH Terms:
Protein-Tyrosine Kinases*
Proto-Oncogene Proteins*/metabolism
Humans ; Male ; Mice ; Animals ; Ligands ; Semen ; Testis/metabolism ; Epididymis/metabolism ; Spermatozoa/metabolism ; Nerve Tissue Proteins
Czasopismo naukowe
Tytuł:
Screening and Characterization of Allosteric Small Molecules Targeting Bruton's Tyrosine Kinase.
Autorzy:
Kueffer LE; Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, United States.
Lin DY; Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, United States.
Amatya N; Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, United States.
Serrenho J; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Joseph RE; Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, United States.
Courtney AH; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Andreotti AH; Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, United States.
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Źródło:
Biochemistry [Biochemistry] 2024 Jan 02; Vol. 63 (1), pp. 94-106. Date of Electronic Publication: 2023 Dec 13.
Typ publikacji:
Journal Article
MeSH Terms:
Protein-Tyrosine Kinases*/chemistry
Signal Transduction*
Humans ; Agammaglobulinaemia Tyrosine Kinase ; Mutation ; Binding Sites
Czasopismo naukowe

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