Temat: "Proteinase Inhibitors" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Ligand-Based Design of Selective Peptidomimetic uPA and TMPRSS2 Inhibitors with Arg Bioisosteres.
Autorzy:: Müller P; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudinger Weg 5, D-55128 Mainz, Germany.
Zimmer C; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudinger Weg 5, D-55128 Mainz, Germany.
Frey A; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudinger Weg 5, D-55128 Mainz, Germany.
Holzmann G; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudinger Weg 5, D-55128 Mainz, Germany.
Weldert AC; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudinger Weg 5, D-55128 Mainz, Germany.
Schirmeister T; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudinger Weg 5, D-55128 Mainz, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 23; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 23.
Typ publikacji:: Journal Article
MeSH Terms:: Peptidomimetics*/chemistry
Peptidomimetics*/pharmacology
Urokinase-Type Plasminogen Activator*/metabolism
Serine Proteinase Inhibitors*/chemistry
Serine Proteinase Inhibitors*/pharmacology
Ligands ; Peptide Hydrolases ; Trypsin ; Serine Endopeptidases

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Skocz do pozycji: 2.

Tytuł:: The Inhibition of Serine Proteases by Serpins Is Augmented by Negatively Charged Heparin: A Concise Review of Some Clinically Relevant Interactions.
Autorzy:: Chan, Edward D. (AUTHOR)
King, Paul T. (AUTHOR)
Bai, Xiyuan (AUTHOR)
Schoffstall, Allen M. (AUTHOR)
Sandhaus, Robert A. (AUTHOR)
Buckle, Ashley M. (AUTHOR); Pokaż więcej
Źródło:: International Journal of Molecular Sciences. Feb2024, Vol. 25 Issue 3, p1804. 14p.

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Skocz do pozycji: 3.

Tytuł:: Targeted Library of Phosphonic-Type Inhibitors of Human Neutrophil Elastase.
Autorzy:: Torzyk-Jurowska K; Division of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.
Ciekot J; Department of Experimental Oncology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.
Winiarski L; Division of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2024 Mar 01; Vol. 29 (5). Date of Electronic Publication: 2024 Mar 01.
Typ publikacji:: Journal Article
MeSH Terms:: Leukocyte Elastase*/metabolism
Serine Proteases*
Humans ; Cathepsin G ; Myeloblastin/chemistry ; Serine Proteinase Inhibitors/pharmacology

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Skocz do pozycji: 4.

Tytuł:: SERPINA3: A novel inflammatory biomarker associated with cerebral small vessel disease burden in ischemic stroke.
Autorzy:: Hu X; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xiao ZS; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Shen YQ; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yang WS; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wang P; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Li PZ; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wang ZJ; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The Second Hospital of Anhui Medical University, Hefei, China.
Pu MJ; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhao LB; Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Cerebrovascular Disease Research, Chongqing, China.
Xie P; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Li Q; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The Second Hospital of Anhui Medical University, Hefei, China.; Pokaż więcej
Źródło:: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Mar; Vol. 30 (3), pp. e14472. Date of Electronic Publication: 2023 Sep 18.
Typ publikacji:: Journal Article
MeSH Terms:: Ischemic Stroke*/complications
Cerebral Small Vessel Diseases*/complications
Cerebral Small Vessel Diseases*/diagnostic imaging
Serpins*
Humans ; Male ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Magnetic Resonance Imaging ; Serine Proteinase Inhibitors ; Biomarkers ; Inflammation/diagnostic imaging ; Inflammation/complications

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Skocz do pozycji: 5.

Tytuł:: Attachment of Proteolytic Enzyme Inhibitors to Vascular Prosthesis-An Analysis of Binding and Antimicrobial Properties.
Autorzy:: Mordzińska-Rak A; Department of Biochemistry and Biotechnology, Institute of Biological Science, Maria Curie-Skłodowska University, Akademicka 19, 20-031 Lublin, Poland.
Szałapata K; Department of Biochemistry and Biotechnology, Institute of Biological Science, Maria Curie-Skłodowska University, Akademicka 19, 20-031 Lublin, Poland.
Wydrych J; Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka 19, 20-031 Lublin, Poland.
Gagoś M; Department of Cell Biology, Institute of Biological Science, Maria Curie-Skłodowska University, Akademicka 19, 20-031 Lublin, Poland.
Jarosz-Wilkołazka A; Department of Biochemistry and Biotechnology, Institute of Biological Science, Maria Curie-Skłodowska University, Akademicka 19, 20-031 Lublin, Poland.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2024 Feb 21; Vol. 29 (5). Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:: Journal Article
MeSH Terms:: Anti-Infective Agents*
Staphylococcal Infections*
Sulfones*
Humans ; Blood Vessel Prosthesis ; Anti-Bacterial Agents/pharmacology ; Biofilms ; Serine Proteinase Inhibitors/pharmacology ; Staphylococcus aureus ; Biocompatible Materials ; Puromycin ; Peptide Hydrolases

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Skocz do pozycji: 6.

Tytuł:: A Genome-Wide Analysis of Serine Protease Inhibitors in Cydia pomonella Provides Insights into Their Evolution and Expression Pattern.
Autorzy:: Wu Q; Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China.
Xing L; College of Life Sciences, Hebei Basic Science Center for Biotic Interactions, Institute of Life Sciences and Green Development, Hebei University, Baoding 071000, China.
Du M; Shandong Province Key Laboratory for Integrated Control of Plant Diseases and Insect Pests, Sino-Australian Joint Research Institute of Agriculture and Environmental Health, College of Plant Health & Medicine, Qingdao Agricultural University, Qingdao 266109, China.
Huang C; Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China.
Liu B; Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China.
Zhou H; Shandong Province Key Laboratory for Integrated Control of Plant Diseases and Insect Pests, Sino-Australian Joint Research Institute of Agriculture and Environmental Health, College of Plant Health & Medicine, Qingdao Agricultural University, Qingdao 266109, China.
Liu W; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Wan F; Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China.
Qian W; Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 15; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 15.
Typ publikacji:: Journal Article
MeSH Terms:: Serpins*/genetics
Serpins*/chemistry
Moths*/genetics
Animals ; Serine Proteinase Inhibitors/genetics ; Serine Proteinase Inhibitors/pharmacology ; Insecta ; Protein Isoforms

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Skocz do pozycji: 7.

Tytuł:: A Serine Protease Inhibitor, Camostat Mesilate, Suppresses Urinary Plasmin Activity and Alleviates Hypertension and Podocyte Injury in Dahl Salt-Sensitive Rats.
Autorzy:: Iwata Y; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan.
Deng Q; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan.
Kakizoe Y; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan.; Comprehensive Clinical Education, Training and Development Center, Kumamoto University Hospital, Kumamoto 860-8556, Japan.
Nakagawa T; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan.
Miyasato Y; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan.
Nakagawa M; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan.
Nishiguchi K; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan.
Nagayoshi Y; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan.
Narita Y; Department of Pharmacy, Kumamoto University Hospital, Kumamoto 860-8556, Japan.
Izumi Y; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan.
Kuwabara T; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan.
Adachi M; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan.
Mukoyama M; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan.; Comprehensive Clinical Education, Training and Development Center, Kumamoto University Hospital, Kumamoto 860-8556, Japan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 30; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 30.
Typ publikacji:: Journal Article
MeSH Terms:: Podocytes*/metabolism
Hypertension*
Serpins*/pharmacology
Rats ; Animals ; Serine Proteinase Inhibitors/pharmacology ; Serine Proteinase Inhibitors/therapeutic use ; Fibrinolysin ; Rats, Inbred Dahl ; Sodium Chloride, Dietary/pharmacology ; Proteinuria/pathology ; Blood Pressure ; Kidney/metabolism

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Skocz do pozycji: 8.

Tytuł:: Viral SERPINS-A Family of Highly Potent Immune-Modulating Therapeutic Proteins.
Autorzy:: Varkoly K; Department of Internal Medicine, McLaren Macomb Hospital, Michigan State University College of Human Medicine, 1000 Harrington St., Mt Clemens, MI 48043, USA.
Beladi R; Department of Neurological Surgery, Ascension Providence Hospital, Michigan State University College of Human Medicine, 16001 W Nine Mile Rd., Southfield, MI 48075, USA.
Hamada M; College of Medicine, Kansas City University, 1750 Independence Ave, Kansas City, MO 64106, USA.; Center for Immunotherapy Vaccines and Virotherapy, Biodesign Institute, Arizona State University, 727 E Tyler St., Tempe, AZ 85287, USA.
McFadden G; Center for Immunotherapy Vaccines and Virotherapy, Biodesign Institute, Arizona State University, 727 E Tyler St., Tempe, AZ 85287, USA.
Irving J; UCL Respiratory and the Institute of Structural and Molecular Biology, University College London, 5 University Street, London WC1E 6JF, UK.
Lucas AR; Center for Immunotherapy Vaccines and Virotherapy, Biodesign Institute, Arizona State University, 727 E Tyler St., Tempe, AZ 85287, USA.; Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, 727 E Tyler St., Tempe, AZ 85287, USA.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2023 Sep 15; Vol. 13 (9). Date of Electronic Publication: 2023 Sep 15.
Typ publikacji:: Journal Article; Review; Research Support, N.I.H., Extramural
MeSH Terms:: Serpins*/therapeutic use
Serpins*/metabolism
Animals ; Humans ; Serine Proteinase Inhibitors/pharmacology ; Serine Proteinase Inhibitors/therapeutic use ; Serine Endopeptidases ; Serine Proteases ; Mammals/metabolism

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Skocz do pozycji: 9.

Tytuł:: Association between copy number variation of SERPINA3-1 gene and growth traits in Chinese cattle.
Autorzy:: Huang, Yong-zhen (AUTHOR)
Shi, Qiao ting (AUTHOR)
Shi, Shu-yue (AUTHOR)
Yang, Peng (AUTHOR)
Zhang, Zi-jing (AUTHOR)
Lyu, Shi-jie (AUTHOR)
Chen, Fu-ying (AUTHOR)
Xu, Jia-wei (AUTHOR)
Liu, Xian (AUTHOR)
Li, Zhiming (AUTHOR)
Ru, Baorui (AUTHOR)
Cai, Cuicui (AUTHOR)
Xie, Jianliang (AUTHOR)
Lei, ChuZhao (AUTHOR)
Chen, Hong (AUTHOR)
Xu, Zhaoxue (AUTHOR)
Wang, Eryao (AUTHOR); Pokaż więcej
Źródło:: Animal Biotechnology. 2023, Vol. 34 Issue 4, p1524-1531. 8p.

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Skocz do pozycji: 10.

Tytuł:: Nafamostat reduces systemic inflammation in TLR7-mediated virus-like illness.
Autorzy:: Yates AG; Department of Pharmacology, The University of Oxford, Mansfield Road, Oxford, UK.; School of Biomedical Sciences, The University of Queensland, Brisbane, Australia.
Weglinski CM; Department of Pharmacology, The University of Oxford, Mansfield Road, Oxford, UK.
Ying Y; Department of Pharmacology, The University of Oxford, Mansfield Road, Oxford, UK.
Dunstan IK; Department of Pharmacology, The University of Oxford, Mansfield Road, Oxford, UK.
Strekalova T; Sechenov First Moscow State Medical University, Moscow, Russia.; Institute of General Pathology and Pathophysiology, Moscow, Russia.
Anthony DC; Department of Pharmacology, The University of Oxford, Mansfield Road, Oxford, UK. .; Sechenov First Moscow State Medical University, Moscow, Russia. .; University of Southern Denmark, Odense, Denmark. .; Pokaż więcej
Źródło:: Journal of neuroinflammation [J Neuroinflammation] 2022 Jan 06; Vol. 19 (1), pp. 8. Date of Electronic Publication: 2022 Jan 06.
Typ publikacji:: Journal Article
MeSH Terms:: Benzamidines*/pharmacology
Benzamidines*/therapeutic use
Guanidines*/pharmacology
Guanidines*/therapeutic use
Serine Proteinase Inhibitors*/pharmacology
Serine Proteinase Inhibitors*/therapeutic use
Inflammation/*drug therapy
Serine Endopeptidases/*metabolism
Toll-Like Receptor 7/*immunology
Virus Diseases/*drug therapy
Animals ; COVID-19/complications ; Illness Behavior/drug effects ; Imidazoles/administration & dosage ; Imidazoles/immunology ; Inflammation/metabolism ; Inflammation/virology ; Male ; Mice ; Toll-Like Receptor 7/agonists ; Virus Diseases/metabolism ; Virus Diseases/virology ; COVID-19 Drug Treatment

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Skocz do pozycji: 11.

Tytuł:: Enteral administration of the protease inhibitor gabexate mesilate preserves vascular function in experimental trauma/hemorrhagic shock.
Autorzy:: J D Moreira N; Instituto do Coração, Hospital das ClínicasFaculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. .
Dos Santos F; Department of Anesthesiology and Critical Care, University of California, San Diego, La Jolla, CA, USA.
Li JB; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Aletti F; Universidade Federal de São Paulo, São José dos Campos, Brazil.
Irigoyen MCC; Instituto do Coração, Hospital das ClínicasFaculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Kistler EB; Department of Anesthesiology and Critical Care, University of California, San Diego, La Jolla, CA, USA.; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Jun 22; Vol. 13 (1), pp. 10148. Date of Electronic Publication: 2023 Jun 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Shock, Hemorrhagic*/drug therapy
Shock, Hemorrhagic*/enzymology
Gabexate/pharmacology ; Gabexate/therapeutic use ; Endothelium/drug effects ; Serine Proteinase Inhibitors/pharmacology ; Serine Proteinase Inhibitors/therapeutic use ; Rats, Wistar ; Male ; Animals ; Rats

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Skocz do pozycji: 12.

Tytuł:: SPINK2 Protein Expression Is an Independent Adverse Prognostic Marker in AML and Is Potentially Implicated in the Regulation of Ferroptosis and Immune Response.
Autorzy:: Pitts HA; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.
Cheng CK; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.
Cheung JS; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.
Sun MK; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.
Yung YL; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.
Chan HY; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.
Wong RSM; Sir Y.K. Pao Centre for Cancer, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Yip SF; Department of Clinical Pathology, Tuen Mun Hospital, Hong Kong SAR, China.
Lau KN; Department of Clinical Pathology, Tuen Mun Hospital, Hong Kong SAR, China.
Wong WS; Pathology Department, Queen Elizabeth Hospital, Hong Kong SAR, China.
Raghupathy R; Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Chan NPH; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.
Ng MHL; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.; State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong, Hong Kong SAR, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 02; Vol. 24 (11). Date of Electronic Publication: 2023 Jun 02.
Typ publikacji:: Journal Article
MeSH Terms:: Ferroptosis*/genetics
Leukemia, Myeloid, Acute*/diagnosis
Leukemia, Myeloid, Acute*/genetics
Leukemia, Myeloid, Acute*/drug therapy
Humans ; Prognosis ; Serine Proteinase Inhibitors/blood ; Serine Proteinase Inhibitors/metabolism ; Serpins/blood ; Serpins/metabolism

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Skocz do pozycji: 13.

Tytuł:: Predicting Diagnostic Potential of Cathepsin in Epithelial Ovarian Cancer: A Design Validated by Computational, Biophysical and Electrochemical Data.
Autorzy:: Ranade H; Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, India.
Paliwal P; Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, India.
Chaudhary AA; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh 11564, Saudi Arabia.
Piplani S; Vaxine Pty Ltd., Flinders University, Bedford Park, SA 5042, Australia.
Rudayni HA; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh 11564, Saudi Arabia.
Al-Zharani M; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh 11564, Saudi Arabia.
Niraj RR; Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, India.
Datta M; Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, India.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2021 Dec 30; Vol. 12 (1). Date of Electronic Publication: 2021 Dec 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cysteine Proteinase Inhibitors*/chemistry
Ovarian Neoplasms*/diagnosis
Carcinoma, Ovarian Epithelial ; Cathepsin L ; Endopeptidases ; Humans ; Protease Inhibitors

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Skocz do pozycji: 14.

Tytuł:: Serpin family proteins as potential biomarkers and therapeutic drugs in stroke: A systematic review and meta‐analysis on clinical/preclinical studies.
Autorzy:: Yan, Bing (AUTHOR)
Luo, Lu (AUTHOR)
Liu, Li (AUTHOR)
Wang, Zhenyu (AUTHOR)
Chen, Ruiying (AUTHOR)
Wu, Yi (AUTHOR)
Xiao, Xiao (AUTHOR); Pokaż więcej
Źródło:: CNS Neuroscience & Therapeutics. Jul2023, Vol. 29 Issue 7, p1738-1749. 12p.

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Skocz do pozycji: 15.

Tytuł:: Bioguided Isolation of Cyclopenin Analogues as Potential SARS-CoV-2 M Inhibitors from Penicillium citrinum TDPEF34.
Autorzy:: Thissera B; School of Computing, Engineering & Physical Science, University of the West of Scotland, Paisley PA1 2BE, UK.
Sayed AM; Department of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef 62513, Egypt.
Hassan MHA; Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
Abdelwahab SF; Department of Pharmaceutics and Industrial Pharmacy, Taif College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Amaeze N; School of Health and Life Sciences, University of the West of Scotland, Paisley PA1 2BE, UK.
Semler VT; School of Computing, Engineering & Physical Science, University of the West of Scotland, Paisley PA1 2BE, UK.
Alenezi FN; The Public Authority for Applied Education and Training, Adailiyah 00965, Kuwait.
Yaseen M; School of Computing, Engineering & Physical Science, University of the West of Scotland, Paisley PA1 2BE, UK.
Alhadrami HA; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, P.O. Box 80402, Jeddah 21589, Saudi Arabia.; Molecular Diagnostic Lab, King Abdulaziz University Hospital, King Abdulaziz University, P.O. Box 80402, Jeddah 21589, Saudi Arabia.
Belbahri L; Laboratory of Soil Biology, University of Neuchatel, 2000 Neuchatel, Switzerland.
Rateb ME; School of Computing, Engineering & Physical Science, University of the West of Scotland, Paisley PA1 2BE, UK.; Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, UK.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2021 Sep 15; Vol. 11 (9). Date of Electronic Publication: 2021 Sep 15.
Typ publikacji:: Journal Article
MeSH Terms:: Coronavirus 3C Proteases*/antagonists & inhibitors
Coronavirus 3C Proteases*/chemistry
Cysteine Proteinase Inhibitors*/chemistry
Cysteine Proteinase Inhibitors*/isolation & purification
Molecular Docking Simulation*
Molecular Dynamics Simulation*
Penicillium/*chemistry
SARS-CoV-2/*enzymology
Benzodiazepinones/chemistry ; Benzodiazepinones/isolation & purification
SCR Organism:: Penicillium citrinum

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Skocz do pozycji: 16.

Tytuł:: Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.
Autorzy:: Drayman N; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA. .
DeMarco JK; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA.
Jones KA; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Chemistry, The University of Chicago, Chicago, IL, USA.
Azizi SA; Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.; Department of Chemistry, The University of Chicago, Chicago, IL, USA.
Froggatt HM; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France.; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
Tan K; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA.
Maltseva NI; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA.
Chen S; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Cellular Screening Center, The University of Chicago, Chicago, IL, USA.
Nicolaescu V; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.
Dvorkin S; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.
Furlong K; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.
Kathayat RS; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Chemistry, The University of Chicago, Chicago, IL, USA.
Firpo MR; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA.; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Mastrodomenico V; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Bruce EA; Cellular Screening Center, The University of Chicago, Chicago, IL, USA.; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Schmidt MM; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Jedrzejczak R; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA.
Muñoz-Alía MÁ; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
Schuster B; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA.
Nair V; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA.
Han KY; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA.; Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
O'Brien A; Department of Pharmaceutical Sciences, College of Pharmacy, Biophysics Core at Research Resources Center, University of Illinois at Chicago, Chicago, IL, USA.; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Tomatsidou A; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.
Meyer B; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France.
Vignuzzi M; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA.; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France.
Missiakas D; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.
Botten JW; Cellular Screening Center, The University of Chicago, Chicago, IL, USA.; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Brooke CB; Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Lee H; Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Pharmaceutical Sciences, College of Pharmacy, Biophysics Core at Research Resources Center, University of Illinois at Chicago, Chicago, IL, USA.
Baker SC; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France.; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA.; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Mounce BC; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France.; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Heaton NS; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France.; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
Severson WE; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA.
Palmer KE; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA.
Dickinson BC; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Chemistry, The University of Chicago, Chicago, IL, USA.
Joachimiak A; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA.; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.
Randall G; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.
Tay S; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA. .; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2021 Aug 20; Vol. 373 (6557), pp. 931-936. Date of Electronic Publication: 2021 Jul 20.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: COVID-19 Drug Treatment*
Antiviral Agents/*pharmacology
Coronavirus 3C Proteases/*antagonists & inhibitors
Coronavirus OC43, Human/*drug effects
Cysteine Proteinase Inhibitors/*pharmacology
SARS-CoV-2/*drug effects
Thiazoles/*pharmacology
A549 Cells ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Antiviral Agents/therapeutic use ; Benzamides ; COVID-19/virology ; Catalytic Domain ; Coronavirus 3C Proteases/chemistry ; Coronavirus 3C Proteases/metabolism ; Coronavirus OC43, Human/physiology ; Cysteine Proteinase Inhibitors/chemistry ; Cysteine Proteinase Inhibitors/metabolism ; HEK293 Cells ; Humans ; Inhibitory Concentration 50 ; Mice ; Mice, Transgenic ; Microbial Sensitivity Tests ; Piperidines ; Pyridines ; SARS-CoV-2/enzymology ; SARS-CoV-2/physiology ; Thiazoles/chemistry ; Thiazoles/metabolism ; Thiazoles/therapeutic use ; Viral Load/drug effects ; Virus Replication/drug effects

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Tytuł:: Identification of 13 Guanidinobenzoyl- or Aminidinobenzoyl-Containing Drugs to Potentially Inhibit TMPRSS2 for COVID-19 Treatment.
Autorzy:: Huang X; Department of Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.
Pearce R; Department of Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.
Omenn GS; Department of Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.; Departments of Internal Medicine and Human Genetics and School of Public Health, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.
Zhang Y; Department of Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.; Department of Biological Chemistry, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jun 30; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 30.
Typ publikacji:: Journal Article
MeSH Terms:: Antiviral Agents/*chemistry
Serine Endopeptidases/*metabolism
Serine Proteinase Inhibitors/*chemistry
Antiviral Agents/metabolism ; Antiviral Agents/therapeutic use ; Benzamidines/chemistry ; Benzamidines/metabolism ; Binding Sites ; COVID-19/pathology ; COVID-19/virology ; Catalytic Domain ; Esters/chemistry ; Esters/metabolism ; Guanidines/chemistry ; Guanidines/metabolism ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Serine Endopeptidases/chemistry ; Serine Proteinase Inhibitors/metabolism ; Serine Proteinase Inhibitors/therapeutic use ; Thermodynamics ; COVID-19 Drug Treatment

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Skocz do pozycji: 18.

Tytuł:: The recombinant plant Bauhinia bauhinioides elastase inhibitor reduces rat thrombus without alterations in hemostatic parameters.
Autorzy:: Oliveira C; Departamento de Bioquímica, Universidade Federal de São Paulo, Rua Três de Maio, 100, São Paulo, SP, 04044-020, Brazil.
Valois MV; Departamento de Bioquímica, Universidade Federal de São Paulo, Rua Três de Maio, 100, São Paulo, SP, 04044-020, Brazil.
Ottaiano TF; Departamento de Bioquímica, Universidade Federal de São Paulo, Rua Três de Maio, 100, São Paulo, SP, 04044-020, Brazil.
Miranda A; Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo, SP, 04044-020, Brazil.
Hansen D; Departamento de Bioquímica, Universidade Federal de São Paulo, Rua Três de Maio, 100, São Paulo, SP, 04044-020, Brazil.
Sampaio MU; Departamento de Bioquímica, Universidade Federal de São Paulo, Rua Três de Maio, 100, São Paulo, SP, 04044-020, Brazil.
Oliva MLV; Departamento de Bioquímica, Universidade Federal de São Paulo, Rua Três de Maio, 100, São Paulo, SP, 04044-020, Brazil. .
de Abreu Maffei FH; Departamento de Cirurgia e Ortopedia, Universidade Estadual Paulista, Botucatu, SP, 18618-970, Brazil.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Jun 29; Vol. 11 (1), pp. 13475. Date of Electronic Publication: 2021 Jun 29.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Thrombosis*/blood
Thrombosis*/drug therapy
Bauhinia/*enzymology
Plant Proteins/*pharmacology
Serine Proteinase Inhibitors/*pharmacology
Animals ; Bauhinia/genetics ; Blood Coagulation/drug effects ; Humans ; Male ; Pancreatic Elastase/antagonists & inhibitors ; Pancreatic Elastase/blood ; Partial Thromboplastin Time ; Plant Proteins/chemistry ; Plant Proteins/genetics ; Rats ; Rats, Wistar ; Recombinant Proteins/genetics ; Recombinant Proteins/pharmacology ; Serine Proteinase Inhibitors/chemistry ; Serine Proteinase Inhibitors/genetics

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Skocz do pozycji: 19.

Tytuł:: In silico identification of noncompetitive inhibitors targeting an uncharacterized allosteric site of falcipain-2.
Autorzy:: Hernández González JE; Departamento de Física, Instituto de Biociências, Letras e Ciências Exatas - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Rua Cristóvão Colombo 2265, Jardim Nazareth, São José do Rio Preto, SP, CEP 15054-000, Brazil. .; Laboratório de Modelagem e Dinâmica Molecular, Instituto de Biofı́sica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Ave. Carlos Chagas Filho - Universidade Federal do Rio de Janeiro (UFRJ), Ave. Carlos Chagas Filho, 373, CCS-Bloco D sala 30, Cidade Universitária Ilha de Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil. .; Institute for Molecular Modeling and Simulation, Department for Material Sciences and Process Engineering - University of Natural Resources and Life Sciences (BOKU), Vienna, Muthgasse 18, 1190, Vienna, Austria. .
Salas-Sarduy E; Instituto de Investigaciones Biotecnológicas Dr. Rodolfo Ugalde, Universidad Nacional de San Martín, CONICET, San Martín, Buenos Aires, Argentina.
Hernández Alvarez L; Departamento de Física, Instituto de Biociências, Letras e Ciências Exatas - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Rua Cristóvão Colombo 2265, Jardim Nazareth, São José do Rio Preto, SP, CEP 15054-000, Brazil.
Barreto Gomes DE; Laboratório de Modelagem e Dinâmica Molecular, Instituto de Biofı́sica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Ave. Carlos Chagas Filho - Universidade Federal do Rio de Janeiro (UFRJ), Ave. Carlos Chagas Filho, 373, CCS-Bloco D sala 30, Cidade Universitária Ilha de Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil.; Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora (UFJF), Rua José Lourenço Kelmer, s/n - Campus Universitário, Bairro São Pedro, Juiz de Fora, MG, CEP 36036-900, Brazil.
Pascutti PG; Laboratório de Modelagem e Dinâmica Molecular, Instituto de Biofı́sica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Ave. Carlos Chagas Filho - Universidade Federal do Rio de Janeiro (UFRJ), Ave. Carlos Chagas Filho, 373, CCS-Bloco D sala 30, Cidade Universitária Ilha de Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil.
Oostenbrink C; Institute for Molecular Modeling and Simulation, Department for Material Sciences and Process Engineering - University of Natural Resources and Life Sciences (BOKU), Vienna, Muthgasse 18, 1190, Vienna, Austria.
Leite VBP; Departamento de Física, Instituto de Biociências, Letras e Ciências Exatas - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Rua Cristóvão Colombo 2265, Jardim Nazareth, São José do Rio Preto, SP, CEP 15054-000, Brazil.; Pokaż więcej
Źródło:: Journal of computer-aided molecular design [J Comput Aided Mol Des] 2021 Oct; Vol. 35 (10), pp. 1067-1079. Date of Electronic Publication: 2021 Oct 07.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Computer Simulation*
Antimalarials/*pharmacology
Cysteine Endopeptidases/*chemistry
Cysteine Proteinase Inhibitors/*pharmacology
Plasmodium falciparum/*drug effects
Allosteric Site ; Antimalarials/chemistry ; Cysteine Proteinase Inhibitors/chemistry ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Plasmodium falciparum/enzymology ; Protein Binding ; Structure-Activity Relationship

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Skocz do pozycji: 20.

Tytuł:: A phase I study of high dose camostat mesylate in healthy adults provides a rationale to repurpose the TMPRSS2 inhibitor for the treatment of COVID-19.
Autorzy:: Kitagawa J; Clinical Pharmacology, Ono Pharmaceutical Co., Ltd., Osaka, Japan.; Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Fukuoka, Japan.
Arai H; Clinical Pharmacology, Ono Pharmaceutical Co., Ltd., Osaka, Japan.
Iida H; Clinical Pharmacology, Ono Pharmaceutical Co., Ltd., Osaka, Japan.
Mukai J; Clinical Pharmacology, Ono Pharmaceutical Co., Ltd., Osaka, Japan.
Furukawa K; Clinical Pharmacology, Ono Pharmaceutical Co., Ltd., Osaka, Japan.
Ohtsu S; Pharmacokinetic Research, Ono Pharmaceutical Co., Ltd., Ibaraki, Japan.
Nakade S; Clinical Pharmacology, Ono Pharmaceutical Co., Ltd., Osaka, Japan.
Hikima T; Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Fukuoka, Japan.
Haranaka M; SOUSEIKAI Hakata Clinic, Fukuoka, Japan.
Uemura N; Department of Clinical Pharmacology and Therapeutics, Faculty of Medicine, Oita University, Oita, Japan.; Pokaż więcej
Źródło:: Clinical and translational science [Clin Transl Sci] 2021 Sep; Vol. 14 (5), pp. 1967-1976. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji:: Clinical Trial, Phase I; Journal Article
MeSH Terms:: Drug Repositioning*
COVID-19 Drug Treatment*
Esters/*adverse effects
Guanidines/*adverse effects
Serine Proteinase Inhibitors/*administration & dosage
Administration, Oral ; Adolescent ; Adult ; Computer Simulation ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Esters/administration & dosage ; Esters/pharmacokinetics ; Food-Drug Interactions ; Guanidines/administration & dosage ; Guanidines/pharmacokinetics ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; Models, Biological ; Serine Endopeptidases/metabolism ; Serine Proteinase Inhibitors/adverse effects ; Young Adult

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