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Wyszukujesz frazę ""Proteolysis"" wg kryterium: Temat


Tytuł :
N-terminome analyses underscore the prevalence of SPPL3-mediated intramembrane proteolysis among Golgi-resident enzymes and its role in Golgi enzyme secretion.
Autorzy :
Hobohm L; Institute of Biochemistry, Kiel University, Rudolf-Höber-Str. 1, 24118, Kiel, Germany.
Koudelka T; Systematic Proteome Research and Bioanalytics, Institute for Experimental Medicine, Kiel University, 24105, Kiel, Germany.
Bahr FH; Institute of Biochemistry, Kiel University, Rudolf-Höber-Str. 1, 24118, Kiel, Germany.
Truberg J; Institute of Biochemistry, Kiel University, Rudolf-Höber-Str. 1, 24118, Kiel, Germany.
Kapell S; National Bioinformatics Infrastructure Sweden (NBIS), Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 10691, Stockholm, Sweden.
Schacht SS; Institute of Biochemistry, Kiel University, Rudolf-Höber-Str. 1, 24118, Kiel, Germany.; Institute of Immunology, University Medical Center Schleswig-Holstein, 24105, Kiel, Germany.
Meisinger D; Institute of Biochemistry, Kiel University, Rudolf-Höber-Str. 1, 24118, Kiel, Germany.
Mengel M; Institute of Biochemistry, Kiel University, Rudolf-Höber-Str. 1, 24118, Kiel, Germany.
Jochimsen A; Institute of Biochemistry, Kiel University, Rudolf-Höber-Str. 1, 24118, Kiel, Germany.
Hofmann A; Institute of Biochemistry, Kiel University, Rudolf-Höber-Str. 1, 24118, Kiel, Germany.
Heintz L; Institute of Biochemistry, Kiel University, Rudolf-Höber-Str. 1, 24118, Kiel, Germany.; Institute for Cellular and Integrative Physiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
Tholey A; Systematic Proteome Research and Bioanalytics, Institute for Experimental Medicine, Kiel University, 24105, Kiel, Germany.
Voss M; Institute of Biochemistry, Kiel University, Rudolf-Höber-Str. 1, 24118, Kiel, Germany. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2022 Mar 13; Vol. 79 (3), pp. 185. Date of Electronic Publication: 2022 Mar 13.
Typ publikacji :
Journal Article
MeSH Terms :
Proteolysis*
Aspartic Acid Endopeptidases/*metabolism
Golgi Apparatus/*metabolism
N-Acetylgalactosaminyltransferases/*metabolism
Proteome/*analysis
Aspartic Acid Endopeptidases/deficiency ; Aspartic Acid Endopeptidases/genetics ; Catalytic Domain/genetics ; Gene Editing ; HEK293 Cells ; HeLa Cells ; Humans ; Mutagenesis, Site-Directed ; N-Acetylgalactosaminyltransferases/genetics ; Proteomics/methods ; RNA, Guide/metabolism ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Mouse Adenovirus Type 1 E4orf6 Induces PKR Degradation.
Autorzy :
Tejera-Hernández B; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Goodman DE; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Nevarez JM; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Spindler KR; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
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Źródło :
Journal of virology [J Virol] 2022 Apr 13; Vol. 96 (7), pp. e0206321. Date of Electronic Publication: 2022 Mar 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenoviridae*/genetics
Adenoviridae*/metabolism
Adenoviridae Infections*/enzymology
Proteolysis*
eIF-2 Kinase*/metabolism
Adenovirus E1B Proteins/metabolism ; Adenovirus E4 Proteins/genetics ; Adenovirus E4 Proteins/metabolism ; Adenoviruses, Human/genetics ; Animals ; Humans ; Mice ; Proteasome Endopeptidase Complex/metabolism ; Viral Proteins/genetics ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC).
Autorzy :
Chotitumnavee J; SANKEN, Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan. .; Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1-5 Shimogamohangi-cho, Sakyo-ku, Kyoto 606-0823, Japan.
Yamashita Y; SANKEN, Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan. .
Takahashi Y; Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1-5 Shimogamohangi-cho, Sakyo-ku, Kyoto 606-0823, Japan.
Takada Y; SANKEN, Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan. .
Iida T; SANKEN, Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan. .; Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1-5 Shimogamohangi-cho, Sakyo-ku, Kyoto 606-0823, Japan.
Oba M; Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1-5 Shimogamohangi-cho, Sakyo-ku, Kyoto 606-0823, Japan.
Itoh Y; SANKEN, Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan. .; Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1-5 Shimogamohangi-cho, Sakyo-ku, Kyoto 606-0823, Japan.
Suzuki T; SANKEN, Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan. .; Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1-5 Shimogamohangi-cho, Sakyo-ku, Kyoto 606-0823, Japan.
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Źródło :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2022 Apr 07; Vol. 58 (29), pp. 4635-4638. Date of Electronic Publication: 2022 Apr 07.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*/methods
Histone Deacetylase Inhibitors*/chemistry
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylases*/metabolism
Proteolysis*
Repressor Proteins*/metabolism
Humans ; Jurkat Cells
Czasopismo naukowe
Tytuł :
Tsc2 knockout counteracts ubiquitin-proteasome system insufficiency and delays photoreceptor loss in retinitis pigmentosa.
Autorzy :
Wang Y; Department of Ophthalmology, University of Florida, Gainesville, FL 32610.
Punzo C; Department of Ophthalmology and Visual Sciences, University of Massachusetts Medical School, Worcester, MA 01655.
Ash JD; Department of Ophthalmology, University of Florida, Gainesville, FL 32610.
Lobanova ES; Department of Ophthalmology, University of Florida, Gainesville, FL 32610.; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Mar 15; Vol. 119 (11), pp. e2118479119. Date of Electronic Publication: 2022 Mar 11.
Typ publikacji :
Journal Article
MeSH Terms :
Proteasome Endopeptidase Complex*/genetics
Proteasome Endopeptidase Complex*/metabolism
Proteolysis*
Retinal Rod Photoreceptor Cells*/metabolism
Retinal Rod Photoreceptor Cells*/pathology
Retinitis Pigmentosa*/genetics
Retinitis Pigmentosa*/metabolism
Retinitis Pigmentosa*/pathology
Ubiquitin*/genetics
Ubiquitin*/metabolism
Animals ; Disease Models, Animal ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mice ; Mice, Knockout ; Tuberous Sclerosis Complex 2 Protein/genetics ; Tuberous Sclerosis Complex 2 Protein/metabolism ; Ubiquitinated Proteins/metabolism
Czasopismo naukowe
Tytuł :
RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1.
Autorzy :
Yang Y; Department of Gastroenterology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing, 100730, China.
Cao X; Department of Gastroenterology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing, 100730, China.
Huang L; Emergency Department, The Aerospace Central Hospital, Beijing, 100049, China.
Yang A; Department of Gastroenterology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing, 100730, China. Electronic address: .
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Źródło :
Molecular immunology [Mol Immunol] 2022 Mar; Vol. 143, pp. 1-6. Date of Electronic Publication: 2022 Jan 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity*
Proteolysis*
Antiviral Agents/*immunology
Protein Serine-Threonine Kinases/*metabolism
RNA Viruses/*immunology
Ubiquitin-Protein Ligases/*metabolism
Animals ; Herpesvirus 1, Human/physiology ; Interferon Type I/metabolism ; Lysine/metabolism ; Macrophages, Peritoneal/metabolism ; Macrophages, Peritoneal/virology ; Male ; Mice, Inbred C57BL ; Ubiquitination ; Vesiculovirus/physiology
Czasopismo naukowe
Tytuł :
Hyperphosphatemia-induced degradation of transcription factor EB exacerbates vascular calcification.
Autorzy :
Ishiwata R; Department of Physiology, National Defense Medical College, Japan. Electronic address: .
Morimoto Y; Department of Physiology, National Defense Medical College, Japan.
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Źródło :
Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2022 Mar 01; Vol. 1868 (3), pp. 166323. Date of Electronic Publication: 2021 Dec 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteolysis*
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/*metabolism
Hyperphosphatemia/*complications
Renal Insufficiency, Chronic/*complications
Vascular Calcification/*pathology
Animals ; Autophagy ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Rats ; Rats, Wistar ; Vascular Calcification/etiology ; Vascular Calcification/metabolism
Czasopismo naukowe
Tytuł :
Ectodomain shedding by ADAM proteases as a central regulator in kidney physiology and disease.
Autorzy :
Meyer-Schwesinger C; Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Seipold L; Biochemical Institute, Christian-Albrechts-University Kiel, Olshausenstrasse 40, D-24098 Kiel, Germany.
Saftig P; Biochemical Institute, Christian-Albrechts-University Kiel, Olshausenstrasse 40, D-24098 Kiel, Germany. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2022 Mar; Vol. 1869 (3), pp. 119165. Date of Electronic Publication: 2021 Oct 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Proteolysis*
ADAM Proteins/*metabolism
Kidney/*physiopathology
Kidney Diseases/*pathology
Membrane Proteins/*metabolism
ADAM Proteins/genetics ; Animals ; Humans ; Kidney/enzymology ; Kidney Diseases/enzymology
Czasopismo naukowe
Tytuł :
Pseudomonas aeruginosa Triggered Exosomal Release of ADAM10 Mediates Proteolytic Cleavage in Trans.
Autorzy :
Aljohmani A; Institute of Experimental and Clinical Pharmacology and Toxicology, PZMS, ZHMB, Saarland University, 66421 Homburg, Germany.
Opitz B; Department of Infectious Diseases and Respiratory Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Bischoff M; Institute for Medical Microbiology and Hygiene, Saarland University, 66421 Homburg, Germany.
Yildiz D; Institute of Experimental and Clinical Pharmacology and Toxicology, PZMS, ZHMB, Saarland University, 66421 Homburg, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 23; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 23.
Typ publikacji :
Journal Article
MeSH Terms :
Proteolysis*
ADAM10 Protein/*metabolism
Amyloid Precursor Protein Secretases/*metabolism
Antigens, CD/*metabolism
Cadherins/*metabolism
Membrane Proteins/*metabolism
A549 Cells ; Epithelium/metabolism ; Exosomes/metabolism ; Exosomes/physiology ; Humans ; Inflammation/microbiology ; Pseudomonas aeruginosa/metabolism ; Pseudomonas aeruginosa/pathogenicity ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Function and proteolytic generation of the soluble interleukin-6 receptor in health and disease.
Autorzy :
Schumertl T; Department of Pathology, Otto-von-Guericke-University Magdeburg, Medical Faculty, Magdeburg, Germany.
Lokau J; Department of Pathology, Otto-von-Guericke-University Magdeburg, Medical Faculty, Magdeburg, Germany.
Rose-John S; Institute of Biochemistry, Kiel University, 24118 Kiel, Germany.
Garbers C; Department of Pathology, Otto-von-Guericke-University Magdeburg, Medical Faculty, Magdeburg, Germany. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2022 Jan; Vol. 1869 (1), pp. 119143. Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Proteolysis*
Inflammatory Bowel Diseases/*drug therapy
Receptors, Interleukin-6/*metabolism
Animals ; Anti-Inflammatory Agents/pharmacology ; Humans ; Interleukin-6/metabolism ; Receptors, Interleukin-6/genetics ; Recombinant Fusion Proteins/pharmacology ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
The role of proteolysis in interleukin-11 signaling.
Autorzy :
Lokau J; Department of Pathology, Otto-von-Guericke-University Magdeburg, Medical Faculty, Magdeburg, Germany.
Kespohl B; Department of Pathology, Otto-von-Guericke-University Magdeburg, Medical Faculty, Magdeburg, Germany.
Kirschke S; Department of Pathology, Otto-von-Guericke-University Magdeburg, Medical Faculty, Magdeburg, Germany.
Garbers C; Department of Pathology, Otto-von-Guericke-University Magdeburg, Medical Faculty, Magdeburg, Germany. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2022 Jan; Vol. 1869 (1), pp. 119135. Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Proteolysis*
Interleukin-11/*metabolism
Animals ; Humans ; Receptors, Interleukin-11/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Shedding light on both ends: An update on analytical approaches for N- and C-terminomics.
Autorzy :
Koudelka T; Systematic Proteome Research & Bioanalytics, Institute for Experimental Medicine, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Winkels K; Systematic Proteome Research & Bioanalytics, Institute for Experimental Medicine, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Kaleja P; Systematic Proteome Research & Bioanalytics, Institute for Experimental Medicine, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Tholey A; Systematic Proteome Research & Bioanalytics, Institute for Experimental Medicine, Christian-Albrechts-Universität zu Kiel, Kiel, Germany. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2022 Jan; Vol. 1869 (1), pp. 119137. Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Proteolysis*
Proteome/*metabolism
Proteomics/*methods
Animals ; Humans ; Proteome/chemistry ; Proteome/genetics ; RNA Splicing
Czasopismo naukowe
Tytuł :
Proteolytic degradation patterns of the receptor for advanced glycation end products peptide fragments correlate with their neuroprotective activity in Alzheimer's disease models.
Autorzy :
Volpina OM; Department of Molecular Neurobiology, Laboratory of Synthetic Vaccines, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (RAS), Moscow, Russia.
Koroev DO; Department of Molecular Neurobiology, Laboratory of Synthetic Vaccines, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (RAS), Moscow, Russia.
Serebryakova MV; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
Volkova TD; Department of Molecular Neurobiology, Laboratory of Synthetic Vaccines, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (RAS), Moscow, Russia.
Kamynina AV; Department of Molecular Neurobiology, Laboratory of Synthetic Vaccines, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (RAS), Moscow, Russia.; Research Center for Molecular Mechanisms of Aging and Age Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
Bobkova NV; Laboratory of Cellular Mechanisms of Memory Pathology, Institute of Cell Biophysics (RAS), Pushchino, Russia.
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Źródło :
Drug development research [Drug Dev Res] 2021 Dec; Vol. 82 (8), pp. 1217-1226. Date of Electronic Publication: 2021 May 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteolysis*
Alzheimer Disease/*drug therapy
Neuroprotective Agents/*therapeutic use
Peptide Fragments/*therapeutic use
Receptor for Advanced Glycation End Products/*metabolism
Animals ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Male ; Mass Spectrometry ; Mice
Czasopismo naukowe
Tytuł :
Interleukin-6-interleukin-11 receptor chimeras reveal ionomycin-induced proteolysis beyond ADAM10.
Autorzy :
Lokau J; Department of Pathology, Medical Faculty, Otto-von-Guericke-University, Magdeburg, Germany.
Garbers C; Department of Pathology, Medical Faculty, Otto-von-Guericke-University, Magdeburg, Germany.
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Źródło :
FEBS letters [FEBS Lett] 2021 Dec; Vol. 595 (24), pp. 3072-3082. Date of Electronic Publication: 2021 Nov 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteolysis*/drug effects
ADAM10 Protein/*metabolism
Ionomycin/*pharmacology
Receptors, Interleukin-11/*metabolism
Recombinant Fusion Proteins/*pharmacology
HEK293 Cells ; Humans ; Interleukin-6/chemistry ; Interleukin-6/metabolism ; Protease Inhibitors/pharmacology ; Receptors, Interleukin-11/chemistry
Czasopismo naukowe
Tytuł :
Carbonic anhydrase amyloid fibrils composed of laterally associated protofilaments show reduced cytotoxicity.
Autorzy :
Ryabova N; Institute of Protein Research RAS, Institutskaya St., 4, Pushchino, Russia. Electronic address: .
Fakhranurova L; Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Prospekt Nauki, 6, Pushchino, Russia. Electronic address: .
Balobanov V; Institute of Protein Research RAS, Institutskaya St., 4, Pushchino, Russia. Electronic address: .
Marchenkov V; Institute of Protein Research RAS, Institutskaya St., 4, Pushchino, Russia. Electronic address: .
Glukhov A; Institute of Protein Research RAS, Institutskaya St., 4, Pushchino, Russia. Electronic address: .
Ilyina N; Institute of Protein Research RAS, Institutskaya St., 4, Pushchino, Russia. Electronic address: .
Kochetov A; Pushchino State Institute of Natural Sciences, Prospekt Nauki, 3, Pushchino, Russia. Electronic address: .
Suvorina M; Institute of Protein Research RAS, Institutskaya St., 4, Pushchino, Russia. Electronic address: .
Surin A; Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Prospekt Nauki, 6, Pushchino, Russia; State Research Center for Applied Microbiology and Biotechnology, Kvartal A, 24, Obolensk, Russia. Electronic address: .
Katina N; Institute of Protein Research RAS, Institutskaya St., 4, Pushchino, Russia. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Feb 19; Vol. 593, pp. 46-51. Date of Electronic Publication: 2022 Jan 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Proteolysis*
Amyloid/*toxicity
Carbonic Anhydrases/*metabolism
Fibroblasts/*pathology
Amino Acid Substitution ; Animals ; Carbonic Anhydrases/chemistry ; Carbonic Anhydrases/genetics ; Cattle ; Fibroblasts/enzymology ; Mice ; Toxicity Tests
Czasopismo naukowe
Tytuł :
The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system.
Autorzy :
Ji CH; Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Korea.; AUTOTAC Bio Inc., Changkkyunggung-ro 254, Jongno-gu, Seoul, 03080, Korea.
Kim HY; Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Korea.; AUTOTAC Bio Inc., Changkkyunggung-ro 254, Jongno-gu, Seoul, 03080, Korea.
Lee MJ; Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Korea.; AUTOTAC Bio Inc., Changkkyunggung-ro 254, Jongno-gu, Seoul, 03080, Korea.
Heo AJ; Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Korea.; AUTOTAC Bio Inc., Changkkyunggung-ro 254, Jongno-gu, Seoul, 03080, Korea.
Park DY; Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Korea.
Lim S; Convergence Research Center for Brain Science, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Korea.
Shin S; Convergence Research Center for Brain Science, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Korea.; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology (UST), Seoul, 02792, Korea.
Ganipisetti S; Brown Cancer Center, University of Louisville, 529 S Jackson Street, Louisville, KY, 40202, USA.
Yang WS; Convergence Research Center for Brain Science, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Korea.
Jung CA; AUTOTAC Bio Inc., Changkkyunggung-ro 254, Jongno-gu, Seoul, 03080, Korea.
Kim KY; AUTOTAC Bio Inc., Changkkyunggung-ro 254, Jongno-gu, Seoul, 03080, Korea.
Jeong EH; AUTOTAC Bio Inc., Changkkyunggung-ro 254, Jongno-gu, Seoul, 03080, Korea.
Park SH; AUTOTAC Bio Inc., Changkkyunggung-ro 254, Jongno-gu, Seoul, 03080, Korea.
Bin Kim S; Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Korea.
Lee SJ; Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Korea.
Na JE; AUTOTAC Bio Inc., Changkkyunggung-ro 254, Jongno-gu, Seoul, 03080, Korea.
Kang JI; Anticancer Agents Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongju, 28116, Korea.
Chi HM; Department of Chemisty, Pohang University of Science and Technology, Pohang, 37673, Korea.
Kim HT; AUTOTAC Bio Inc., Changkkyunggung-ro 254, Jongno-gu, Seoul, 03080, Korea.
Kim YK; Convergence Research Center for Brain Science, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Korea. .; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology (UST), Seoul, 02792, Korea. .
Kim BY; Anticancer Agents Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongju, 28116, Korea. .; Department of Biomolecular Science, KRIBB School, University of Science and Technology (UST), Daejeon, 34113, Korea. .
Kwon YT; Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Korea. .; AUTOTAC Bio Inc., Changkkyunggung-ro 254, Jongno-gu, Seoul, 03080, Korea. .; SNU Dementia Research Center, College of Medicine, Seoul National University, Seoul, 110-799, Republic of Korea. .
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Źródło :
Nature communications [Nat Commun] 2022 Feb 16; Vol. 13 (1), pp. 904. Date of Electronic Publication: 2022 Feb 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteolysis*
Autophagy/*physiology
Lysosomes/*metabolism
Oncogene Proteins/*metabolism
Protein Aggregates/*physiology
Cell Line, Tumor ; HeLa Cells ; Humans ; Protein Binding/physiology ; Protein Folding ; Proteostasis/physiology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.
Autorzy :
Lim SA; Department of Pharmaceutical Chemistry.
Zhou J; Department of Pharmaceutical Chemistry.
Martinko AJ; Department of Pharmaceutical Chemistry.
Wang YH; Department of Radiology and Biomedical Imaging, and.; Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, California, USA.
Filippova EV; Department of Biochemistry and Molecular Biology, and.; Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois, USA.
Steri V; Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, California, USA.; Preclinical Therapeutics Core, UCSF, San Francisco, California, USA.
Wang D; Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, California, USA.; Preclinical Therapeutics Core, UCSF, San Francisco, California, USA.
Remesh SG; Department of Pharmaceutical Chemistry.
Liu J; Department of Pharmaceutical Chemistry.
Hann B; Preclinical Therapeutics Core, UCSF, San Francisco, California, USA.
Kossiakoff AA; Department of Biochemistry and Molecular Biology, and.; Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois, USA.
Evans MJ; Department of Radiology and Biomedical Imaging, and.; Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, California, USA.
Leung KK; Department of Pharmaceutical Chemistry.
Wells JA; Department of Pharmaceutical Chemistry.; Chan Zuckerberg Biohub, San Francisco, California, USA.; Department of Cellular and Molecular Pharmacology, UCSF, San Francisco, California, USA.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2022 Feb 15; Vol. 132 (4).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Proteolysis*
Antigens, Neoplasm/*immunology
Cell Adhesion Molecules/*immunology
Epitopes/*immunology
Neoplasm Proteins/*immunology
Neoplasms, Experimental/*immunology
Pancreatic Neoplasms/*immunology
Animals ; Antigens, Neoplasm/genetics ; Cell Adhesion Molecules/genetics ; Cell Line, Tumor ; Epitopes/genetics ; Humans ; Male ; Mice ; Mice, Nude ; Neoplasm Proteins/genetics ; Neoplasms, Experimental/genetics ; Pancreatic Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex.
Autorzy :
Nightingale K; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Potts M; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Hunter LM; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Fielding CA; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom.
Zerbe CM; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Fletcher-Etherington A; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Nobre L; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Wang ECY; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom.
Strang BL; Institute for Infection and Immunity, University of London, London SW17 0RE, United Kingdom.
Houghton JW; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Antrobus R; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Suarez NM; Centre for Virus Research, Medical Research Council, University of Glasgow, Glasgow G61 1QH, United Kingdom.
Nichols J; Centre for Virus Research, Medical Research Council, University of Glasgow, Glasgow G61 1QH, United Kingdom.
Davison AJ; Centre for Virus Research, Medical Research Council, University of Glasgow, Glasgow G61 1QH, United Kingdom.
Stanton RJ; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom.
Weekes MP; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom; .; Department of Medicine, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Feb 08; Vol. 119 (6).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immune Evasion*
Proteolysis*
Cytomegalovirus/*immunology
Cytomegalovirus Infections/*immunology
Nuclear Proteins/*immunology
Viral Envelope Proteins/*immunology
Cytomegalovirus/genetics ; Cytomegalovirus Infections/genetics ; Humans ; Nuclear Proteins/genetics ; Ubiquitin-Protein Ligase Complexes/genetics ; Ubiquitin-Protein Ligase Complexes/immunology ; Viral Envelope Proteins/genetics
Czasopismo naukowe
Tytuł :
The Proteolysis of ECM in Intervertebral Disc Degeneration.
Autorzy :
Liang H; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Luo R; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Li G; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhang W; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Song Y; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yang C; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2022 Feb 02; Vol. 23 (3). Date of Electronic Publication: 2022 Feb 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Proteolysis*
Extracellular Matrix/*metabolism
Intervertebral Disc Degeneration/*metabolism
Low Back Pain/*metabolism
Animals ; Humans
Czasopismo naukowe
Tytuł :
Protein clearance strategies for disease intervention.
Autorzy :
Hommen F; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph Stelzmann Strasse 26, 50931, Cologne, Germany.
Bilican S; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph Stelzmann Strasse 26, 50931, Cologne, Germany.
Vilchez D; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph Stelzmann Strasse 26, 50931, Cologne, Germany. .; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. .; Faculty of Medicine, University Hospital Cologne, Cologne, Germany. .
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Źródło :
Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2022 Feb; Vol. 129 (2), pp. 141-172. Date of Electronic Publication: 2021 Oct 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Neurodegenerative Diseases*/metabolism
Neurodegenerative Diseases*/therapy
Proteolysis*
Autophagy ; Humans ; Proteasome Endopeptidase Complex/metabolism ; Ubiquitin/metabolism
Czasopismo naukowe

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