Temat: "Proto-Oncogene Protein c-ets-2" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: USP39-Mediated Non-Proteolytic Control of ETS2 Suppresses Nuclear Localization and Activity.
Autorzy:: Choi Y; Department of Life Sciences, Sogang University, Seoul 04107, Republic of Korea.
Lee Y; Department of Life Sciences, Sogang University, Seoul 04107, Republic of Korea.
Kim JS; Department of Life Sciences, Sogang University, Seoul 04107, Republic of Korea.
Zhang P; Department of Biological Pharmaceutics, Huazhong University of Science and Technology, Wuhan 430074, China.
Kim J; Department of Life Sciences, Sogang University, Seoul 04107, Republic of Korea.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2023 Oct 01; Vol. 13 (10). Date of Electronic Publication: 2023 Oct 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Proto-Oncogene Protein c-ets-2*/genetics
Proto-Oncogene Protein c-ets-2*/metabolism
Transcription Factors*/metabolism
Humans ; Cell Proliferation ; Ubiquitin-Specific Proteases

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 2.

Tytuł:: Distinct Prognostic and Immunological Roles of ETS1 and ETS2: A Pan-Cancer Analysis.
Autorzy:: Ren Y; Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Chen B; Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Zhang M; Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.; Key Clinical Laboratory of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.; Pokaż więcej
Źródło:: BioMed research international [Biomed Res Int] 2023 Jan 31; Vol. 2023, pp. 4343350. Date of Electronic Publication: 2023 Jan 31 (Print Publication: 2023).
Typ publikacji:: Journal Article
MeSH Terms:: Proto-Oncogene Protein c-ets-1*/genetics
Proto-Oncogene Protein c-ets-1*/metabolism
Proto-Oncogene Protein c-ets-2*/genetics
Proto-Oncogene Protein c-ets-2*/metabolism
Humans ; Carcinogenesis ; Prognosis ; Transcription Factors/metabolism

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 3.

Tytuł:: Association of Cyclin Dependent Kinase 10 and Transcription Factor 2 during Human Corneal Epithelial Wound Healing in vitro model.
Autorzy:: Zehra M; Department of Research, Department of Biochemistry, Ziauddin University, Karachi, 75600, Pakistan.; Department of Biochemistry, University of Karachi, Karachi, 75500, Pakistan.
Mushtaq S; Department of Research, Department of Biochemistry, Ziauddin University, Karachi, 75600, Pakistan. .
Ghulam Musharraf S; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, Karachi, Pakistan.; H.E.J. Research Institute of Chemistry, International, Center for Chemical and Biological Sciences,University of Karachi, Karachi, 75270, Pakistan.
Ghani R; Department of Biochemistry, Jinnah Medical and Dental College, Karachi, 74800, Pakistan.
Ahmed N; Department of Research, Department of Biochemistry, Ziauddin University, Karachi, 75600, Pakistan.; Department of Biochemistry, Barette Hodgson University, Department of Bioscience, Karachi, 74900, Pakistan.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Aug 14; Vol. 9 (1), pp. 11802. Date of Electronic Publication: 2019 Aug 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Wound Healing*
Corneal Injuries/*pathology
Cyclin-Dependent Kinases/*physiology
Epithelium, Corneal/*pathology
Proto-Oncogene Protein c-ets-2/*physiology
Corneal Injuries/metabolism ; Cyclin-Dependent Kinases/metabolism ; Epithelium, Corneal/enzymology ; Epithelium, Corneal/metabolism ; Humans ; In Vitro Techniques ; Models, Biological ; Proto-Oncogene Protein c-ets-2/metabolism

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 4.

Tytuł:: A novel tissue specific alternative splicing variant mitigates phenotypes in Ets2 frame-shift mutant models.
Autorzy:: Kishimoto Y; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara, 630-0192, Japan.
Nishiura I; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara, 630-0192, Japan.
Hirata W; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara, 630-0192, Japan.
Yuri S; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara, 630-0192, Japan.
Yamamoto N; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara, 630-0192, Japan.
Ikawa M; Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Isotani A; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara, 630-0192, Japan. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Apr 15; Vol. 11 (1), pp. 8297. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Phenotype*
Frameshift Mutation/*genetics
Proto-Oncogene Protein c-ets-2/*genetics
RNA Splicing/*genetics
CRISPR-Cas Systems ; DNA-Binding Proteins/genetics ; Embryo Loss/genetics ; Embryo Loss/pathology ; Embryonic Development/genetics ; Exons/genetics ; Female ; Gene Editing/methods ; Humans ; Male ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Skin/metabolism ; Trophoblasts/pathology

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 5.

Tytuł:: Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.
Autorzy:: Li Y; Institute of Molecular and Cell Biology (IMCB), A∗STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore.
Zhou QL; Institute of Molecular and Cell Biology (IMCB), A∗STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore.; Cancer Science Institute of Singapore, 14 Medical Dr #12-01, Singapore 117599, Singapore.
Sun W; Computational and Systems Biology, Genome Institute of Singapore, 60 Biopolis St, Singapore 138672, Singapore.
Chandrasekharan P; Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Agency for Science, Technology and Research Singapore, 11 Biopolis Way, #02-02 Helios, Singapore 138667, Singapore.
Cheng HS; Institute of Molecular and Cell Biology (IMCB), A∗STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore.
Ying Z; Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.; Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Chinese Ministry of Education, Guangzhou, Guangdong 510080, China.
Lakshmanan M; Institute of Molecular and Cell Biology (IMCB), A∗STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore.
Raju A; Institute of Molecular and Cell Biology (IMCB), A∗STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore.
Tenen DG; Cancer Science Institute of Singapore, 14 Medical Dr #12-01, Singapore 117599, Singapore.; Harvard Medical School, Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA.
Cheng SY; Department of Neurology, Northwestern Brain Tumor Institute, Center for Genetic Medicine &The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Chuang KH; Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Agency for Science, Technology and Research Singapore, 11 Biopolis Way, #02-02 Helios, Singapore 138667, Singapore.
Li J; Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.; Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Chinese Ministry of Education, Guangzhou, Guangdong 510080, China.
Prabhakar S; Computational and Systems Biology, Genome Institute of Singapore, 60 Biopolis St, Singapore 138672, Singapore.
Li M; Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.; Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Chinese Ministry of Education, Guangzhou, Guangdong 510080, China.
Tergaonkar V; Institute of Molecular and Cell Biology (IMCB), A∗STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore.; Pokaż więcej
Źródło:: Nature cell biology [Nat Cell Biol] 2015 Oct; Vol. 17 (10), pp. 1327-38. Date of Electronic Publication: 2015 Sep 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Mutation, Missense*
NF-kappa B/*metabolism
Promoter Regions, Genetic/*genetics
Proto-Oncogene Protein c-ets-1/*metabolism
Proto-Oncogene Protein c-ets-2/*metabolism
Telomerase/*genetics
Animals ; Blotting, Western ; Cell Line, Tumor ; Cytokine TWEAK ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Mice, Inbred NOD ; Mice, SCID ; NF-kappa B/genetics ; NF-kappa B p52 Subunit/genetics ; NF-kappa B p52 Subunit/metabolism ; Protein Binding ; Proto-Oncogene Protein c-ets-1/genetics ; Proto-Oncogene Protein c-ets-2/genetics ; RNA Interference ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/genetics ; Transplantation, Heterologous ; Tumor Necrosis Factors/pharmacology

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 6.

Tytuł:: Transcriptional (ChIP-Chip) Analysis of ELF1, ETS2, RUNX1 and STAT5 in Human Abdominal Aortic Aneurysm.
Autorzy:: Pahl MC; Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, PA 17822, USA. .
Erdman R; Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, PA 17822, USA. .
Kuivaniemi H; Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, PA 17822, USA. .; Department of Surgery, Temple University School of Medicine, Philadelphia, PA 19140, USA. .
Lillvis JH; Department of Ophthalmology, Wayne State University School of Medicine, Detroit, MI 48202, USA. .
Elmore JR; Department of Vascular and Endovascular Surgery, Geisinger Health System, Danville, PA 17822, USA. .
Tromp G; Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, PA 17822, USA. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2015 May 18; Vol. 16 (5), pp. 11229-58. Date of Electronic Publication: 2015 May 18.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Aortic Aneurysm, Abdominal/*pathology
Core Binding Factor Alpha 2 Subunit/*metabolism
Nuclear Proteins/*metabolism
Proto-Oncogene Protein c-ets-2/*metabolism
STAT5 Transcription Factor/*metabolism
Transcription Factors/*metabolism
Aged ; Aged, 80 and over ; Aorta/metabolism ; Aorta/pathology ; Aortic Aneurysm, Abdominal/metabolism ; Binding Sites ; Cells, Cultured ; Chromatin Immunoprecipitation ; Core Binding Factor Alpha 2 Subunit/genetics ; Female ; Gene Regulatory Networks ; Humans ; Male ; Middle Aged ; Nuclear Proteins/genetics ; Oligonucleotide Array Sequence Analysis ; Promoter Regions, Genetic ; Protein Binding ; Proto-Oncogene Protein c-ets-2/genetics ; Real-Time Polymerase Chain Reaction ; STAT5 Transcription Factor/genetics ; Transcription Factors/genetics

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 7.

Tytuł:: MicroRNA 17-92 cluster mediates ETS1 and ETS2-dependent RAS-oncogenic transformation.
Autorzy:: Kabbout M; Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America; Graduate Program in Molecular Cellular and Developmental Biology, The Ohio State University, Columbus, Ohio, United States of America; Solid Tumor Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America.
Dakhlallah D; Graduate Program in Molecular Cellular and Developmental Biology, The Ohio State University, Columbus, Ohio, United States of America; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States of America.
Sharma S; Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America; Solid Tumor Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America.
Bronisz A; Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America; Solid Tumor Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America.
Srinivasan R; Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America; Graduate Program in Molecular Cellular and Developmental Biology, The Ohio State University, Columbus, Ohio, United States of America; Solid Tumor Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America.
Piper M; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States of America; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America.
Marsh CB; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States of America; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America.
Ostrowski MC; Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America; Solid Tumor Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2014 Jun 26; Vol. 9 (6), pp. e100693. Date of Electronic Publication: 2014 Jun 26 (Print Publication: 2014).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Carcinogenesis*
Cell Transformation, Neoplastic*
MicroRNAs/*genetics
MicroRNAs/*metabolism
Oncogene Protein p21(ras)/*metabolism
Proto-Oncogene Protein c-ets-1/*metabolism
Proto-Oncogene Protein c-ets-2/*metabolism
Animals ; Cell Line ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Gene Knockout Techniques ; Humans ; Male ; Mice ; Proto-Oncogene Protein c-ets-1/deficiency ; Proto-Oncogene Protein c-ets-1/genetics ; Proto-Oncogene Protein c-ets-2/deficiency ; Proto-Oncogene Protein c-ets-2/genetics ; Proto-Oncogene Proteins c-myc/metabolism

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 8.

Tytuł:: Potential contribution of SIM2 and ETS2 functional polymorphisms in Down syndrome associated malignancies.
Autorzy:: Chatterjee A; Manovikas Biomedical Research and Diagnostic Centre, MRIH, Kolkata, India.
Dutta S
Mukherjee S
Mukherjee N
Dutta A
Mukherjee A
Sinha S
Panda CK
Chaudhuri K
Roy AL
Mukhopadhyay K; Pokaż więcej
Źródło:: BMC medical genetics [BMC Med Genet] 2013 Jan 23; Vol. 14, pp. 12. Date of Electronic Publication: 2013 Jan 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Polymorphism, Single Nucleotide*
Basic Helix-Loop-Helix Transcription Factors/*genetics
Down Syndrome/*complications
Down Syndrome/*genetics
Proto-Oncogene Protein c-ets-2/*genetics
Basic Helix-Loop-Helix Transcription Factors/metabolism ; Breast Neoplasms/etiology ; Breast Neoplasms/genetics ; Case-Control Studies ; Computer Simulation ; Epistasis, Genetic ; Female ; Gene Frequency ; Haplotypes/genetics ; Humans ; India ; Linkage Disequilibrium ; Mouth Neoplasms/etiology ; Mouth Neoplasms/genetics ; Pedigree ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/etiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Proto-Oncogene Protein c-ets-2/metabolism

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 9.

Tytuł:: The SAM domain of human TEL2 can abrogate transcriptional output from TEL1 (ETV-6) and ETS1/ETS2.
Autorzy:: Vivekanand P; Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois, United States of America.
Rebay I; Pokaż więcej
Źródło:: PloS one [PLoS One] 2012; Vol. 7 (5), pp. e37151. Date of Electronic Publication: 2012 May 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Proto-Oncogene Protein c-ets-1/*metabolism
Proto-Oncogene Protein c-ets-2/*metabolism
Proto-Oncogene Proteins c-ets/*metabolism
Repressor Proteins/*metabolism
Transcription, Genetic/*genetics
Transcriptional Activation/*genetics
Animals ; Cells, Cultured ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Drosophila/metabolism ; Drosophila Proteins/metabolism ; Eye Proteins/metabolism ; HeLa Cells ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Protein Interaction Domains and Motifs/genetics ; Protein Structure, Tertiary/genetics ; Proto-Oncogene Protein c-ets-1/genetics ; Proto-Oncogene Protein c-ets-2/genetics ; Proto-Oncogene Proteins c-ets/genetics ; Repressor Proteins/genetics ; ETS Translocation Variant 6 Protein

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 10.

Tytuł:: Ets2-dependent microenvironmental support of mouse mammary tumors.
Autorzy:: Tynan JA; Graduate Program in Molecular Pathology, University of California, San Diego, 9500 Gilman Drive 0612, La Jolla, CA 92093, USA.
Wen F
Muller WJ
Oshima RG; Pokaż więcej
Źródło:: Oncogene [Oncogene] 2005 Oct 20; Vol. 24 (46), pp. 6870-6.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:: Mammary Neoplasms, Experimental/*pathology
Proto-Oncogene Protein c-ets-2/*physiology
Animals ; Base Sequence ; DNA Primers ; Female ; Genotype ; Mammary Neoplasms, Experimental/metabolism ; Mice ; Mice, Inbred BALB C ; Proto-Oncogene Protein c-ets-2/genetics ; Proto-Oncogene Protein c-ets-2/metabolism

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 11.

Tytuł:: Ets-2 and p53 mediate cAMP-induced MMP-2 expression, activity and trophoblast invasion.
Autorzy:: Staun-Ram E; Laboratory for Research in Reproductive Sciences, Department of Obstetrics and Gynecology, Ha'Emek Medical Center, Afula, Israel. />Goldman S
Shalev E; Pokaż więcej
Źródło:: Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2009 Nov 25; Vol. 7, pp. 135. Date of Electronic Publication: 2009 Nov 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cyclic AMP/*pharmacology
Matrix Metalloproteinase 2/*genetics
Matrix Metalloproteinase 2/*metabolism
Proto-Oncogene Protein c-ets-2/*physiology
Trophoblasts/*drug effects
Tumor Suppressor Protein p53/*physiology
Binding Sites/drug effects ; Cell Adhesion/drug effects ; Cell Adhesion/genetics ; Cell Movement/drug effects ; Cell Movement/genetics ; Cells, Cultured ; Colforsin/pharmacology ; Gene Expression/drug effects ; Humans ; Promoter Regions, Genetic/drug effects ; Protein Binding/drug effects ; Proto-Oncogene Protein c-ets-2/metabolism ; Trophoblasts/metabolism ; Trophoblasts/physiology ; Tumor Suppressor Protein p53/metabolism

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 12.

Tytuł:: Ets-2 and C/EBP-beta are important mediators of ovine trophoblast Kunitz domain protein-1 gene expression in trophoblast.
Autorzy:: Chakrabarty A; Departments of Veterinary Pathobiology, University of Missouri-Columbia, Columbia, MO 65211, USA. <>
Roberts MR; Pokaż więcej
Źródło:: BMC molecular biology [BMC Mol Biol] 2007 Feb 27; Vol. 8, pp. 14. Date of Electronic Publication: 2007 Feb 27.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Gene Expression Regulation*
CCAAT-Enhancer-Binding Protein-beta/*metabolism
Proto-Oncogene Protein c-ets-2/*metabolism
Sheep/*genetics
Trophoblasts/*metabolism
Trypsin Inhibitors/*genetics
Animals ; Base Pairing ; Binding Sites ; CCAAT-Enhancer-Binding Protein-beta/genetics ; Choriocarcinoma/enzymology ; Choriocarcinoma/genetics ; Choriocarcinoma/pathology ; Cyclic AMP/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Female ; Humans ; Interferon Type I/genetics ; Interferon Type I/metabolism ; Mice ; Mitogen-Activated Protein Kinases/metabolism ; NIH 3T3 Cells ; Pregnancy ; Pregnancy Proteins/genetics ; Pregnancy Proteins/metabolism ; Promoter Regions, Genetic/genetics ; Protein Binding ; Proto-Oncogene Protein c-ets-2/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Transcription Factor AP-1/genetics ; Transcription, Genetic ; Trypsin Inhibitors/metabolism

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 13.

Tytuł:: High expression of ETS2 predicts poor prognosis in acute myeloid leukemia and may guide treatment decisions.
Autorzy:: Fu L; Department of Hematology and Lymphoma Research Center, Peking University, Third Hospital, Beijing, 100191, China.; Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China.; Department of Hematology, Huaihe Hospital of Henan University, Kaifeng, 475000, China.
Fu H; Department of Nuclear Medicine, Chinese PLA General Hospital, Beijing, 100853, China.
Wu Q; Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China.
Pang Y; Department of Medicine, Wil-liam Beaumont Hospital, Royal Oak, MI, 48073, USA.
Xu K; Northeastern University, Boston, MA, 02115, USA.
Zhou L; Department of Hematology, Chinese PLA General Hospital, Beijing, 100853, China.
Qiao J; Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China.
Ke X; Department of Hematology and Lymphoma Research Center, Peking University, Third Hospital, Beijing, 100191, China. .
Xu K; Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China. .
Shi J; Department of Hematology, Huaihe Hospital of Henan University, Kaifeng, 475000, China. jinlong_.; Department of Biomedical Engineering, Chinese PLA General Hospital, Beijing, 100853, China. jinlong_.; Department of Medical Big Data, Chinese PLA General Hospital, Beijing, 100853, China. jinlong_.; Pokaż więcej
Źródło:: Journal of translational medicine [J Transl Med] 2017 Jul 19; Vol. 15 (1), pp. 159. Date of Electronic Publication: 2017 Jul 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Clinical Decision-Making*
Leukemia, Myeloid, Acute/*metabolism
Proto-Oncogene Protein c-ets-2/*metabolism
Biomarkers, Tumor/metabolism ; Case-Control Studies ; Cohort Studies ; Disease-Free Survival ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Leukemic ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Male ; Middle Aged ; Multivariate Analysis ; Prognosis

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 14.

Tytuł:: Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma.
Autorzy:: Capaldo BJ; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, United States of America.
Roller D; Department of Microbiology, Immunology, and Cancer, University of Virginia, Charlottesville, Virginia, United States of America.
Axelrod MJ; Department of Microbiology, Immunology, and Cancer, University of Virginia, Charlottesville, Virginia, United States of America.
Koeppel AF; Bioinfomatics Core Facility, University of Virginia, Charlottesville, Virginia, United States of America.
Petricoin EF; Center for Applied Proteomics and Molecular Medicine, School of Systems Biology, College of Science, George Mason University, Manassas, Virginia, United States of America.
Slingluff CL Jr; Department of Surgery, University of Virginia, Charlottesville, Virginia, United States of America.
Weber MJ; Department of Microbiology, Immunology, and Cancer, University of Virginia, Charlottesville, Virginia, United States of America.
Mackey AJ; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America.
Gioeli D; Department of Microbiology, Immunology, and Cancer, University of Virginia, Charlottesville, Virginia, United States of America.
Bekiranov S; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 Sep 25; Vol. 10 (9), pp. e0138210. Date of Electronic Publication: 2015 Sep 25 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Mutation, Missense*
Drug Resistance, Neoplasm/*drug effects
Indoles/*pharmacology
MAP Kinase Signaling System/*drug effects
Melanoma/*metabolism
Proto-Oncogene Proteins B-raf/*metabolism
Sulfonamides/*pharmacology
Amino Acid Substitution ; Cell Line, Tumor ; Drug Resistance, Neoplasm/genetics ; Humans ; Melanoma/drug therapy ; Melanoma/genetics ; Melanoma/pathology ; Proto-Oncogene Protein c-ets-2/genetics ; Proto-Oncogene Protein c-ets-2/metabolism ; Proto-Oncogene Proteins B-raf/genetics

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 15.

Tytuł:: VEGFA Expression Is Inhibited by Arsenic Trioxide in HUVECs through the Upregulation of Ets-2 and miRNA-126.
Autorzy:: Ge HY; Key Laboratory of Harbin Medical University Eye Center, Eye Hospital, First Affiliated Hospital, Harbin Medical University, 23 Youzheng Street, Harbin, China.
Han ZJ; Daqing Oilfield General Hospital,9 ZhongKang street, Saertu District of Daqing, China; Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.
Tian P; Key Laboratory of Harbin Medical University Eye Center, Eye Hospital, First Affiliated Hospital, Harbin Medical University, 23 Youzheng Street, Harbin, China.
Sun WJ; Key Laboratory of Harbin Medical University Eye Center, Eye Hospital, First Affiliated Hospital, Harbin Medical University, 23 Youzheng Street, Harbin, China; Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Key Laboratory of Myocardial Ischemia Mechanism and Treatment (Harbin Medical University), Ministry of Education, Baojian Road, Harbin, Heilongjiang Province, PR China.
Xue DX; Key Laboratory of Harbin Medical University Eye Center, Eye Hospital, First Affiliated Hospital, Harbin Medical University, 23 Youzheng Street, Harbin, China.
Bi Y; Key Laboratory of Harbin Medical University Eye Center, Eye Hospital, First Affiliated Hospital, Harbin Medical University, 23 Youzheng Street, Harbin, China.
Yang ZH; Key Laboratory of Harbin Medical University Eye Center, Eye Hospital, First Affiliated Hospital, Harbin Medical University, 23 Youzheng Street, Harbin, China.
Liu P; Key Laboratory of Harbin Medical University Eye Center, Eye Hospital, First Affiliated Hospital, Harbin Medical University, 23 Youzheng Street, Harbin, China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 Aug 14; Vol. 10 (8), pp. e0135795. Date of Electronic Publication: 2015 Aug 14 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Arsenicals/*pharmacology
Down-Regulation/*drug effects
MicroRNAs/*biosynthesis
Oxides/*pharmacology
Proto-Oncogene Protein c-ets-2/*biosynthesis
Up-Regulation/*drug effects
Vascular Endothelial Growth Factor A/*biosynthesis
Apoptosis/drug effects ; Arsenic Trioxide ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Human Umbilical Vein Endothelial Cells ; Humans

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 16.

Tytuł:: CSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth.
Autorzy:: Mathsyaraja H; 1] Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine, Columbus, OH, USA [2] The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Thies K; 1] Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine, Columbus, OH, USA [2] The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Taffany DA; 1] Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine, Columbus, OH, USA [2] The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Deighan C; Department of Chemical Engineering, The Ohio State University, Columbus, OH, USA.
Liu T; The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Yu L; Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
Fernandez SA; Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
Shapiro C; 1] The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA [2] Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, USA.
Otero J; 1] The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA [2] Department of Pathology, Ohio State University College of Medicine, Columbus, OH, USA.
Timmers C; The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Lustberg MB; 1] The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA [2] Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, USA.
Chalmers J; 1] The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA [2] Department of Chemical Engineering, The Ohio State University, Columbus, OH, USA.
Leone G; 1] The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA [2] Department of Molecular Virology, Immunology & Medical Genetics, The Ohio State University College of Medicine, Columbus, OH, USA [3] Department of Molecular Genetics, The Ohio State University, Columbus, OH, USA.
Ostrowski MC; 1] Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine, Columbus, OH, USA [2] The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.; Pokaż więcej
Źródło:: Oncogene [Oncogene] 2015 Jul; Vol. 34 (28), pp. 3651-61. Date of Electronic Publication: 2014 Sep 22.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Breast Neoplasms/*genetics
Breast Neoplasms/*pathology
Macrophages/*metabolism
Melanoma, Experimental/*genetics
MicroRNAs/*genetics
Animals ; Breast Neoplasms/blood supply ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Female ; Humans ; Macrophage Colony-Stimulating Factor/metabolism ; Melanoma, Experimental/metabolism ; Melanoma, Experimental/pathology ; Melanoma, Experimental/secondary ; Mice ; Mice, Inbred C57BL ; Neovascularization, Pathologic/genetics ; Proto-Oncogene Protein c-ets-2/metabolism ; Signal Transduction

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 17.

Tytuł:: Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms.
Autorzy:: Bilsland AE; Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom.
Stevenson K; Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom.
Liu Y; Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom.
Hoare S; Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom.
Cairney CJ; Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom.
Roffey J; Cancer Research Technology Ltd., Wolfson Institute for Biomedical Research, London, United Kingdom.
Keith WN; Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom.; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2014 Feb 13; Vol. 10 (2), pp. e1003448. Date of Electronic Publication: 2014 Feb 13 (Print Publication: 2014).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Models, Genetic*
Neoplasms/*enzymology
Neoplasms/*genetics
Telomerase/*antagonists & inhibitors
Telomerase/*genetics
Cell Line, Tumor ; Computational Biology ; Drug Discovery ; Enzyme Inhibitors/pharmacology ; Female ; Gene Regulatory Networks/genetics ; Genes, myc ; Glycogen Synthase Kinase 3/antagonists & inhibitors ; Humans ; Indoles/pharmacology ; Mathematical Concepts ; Models, Biological ; Neoplasms/drug therapy ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/enzymology ; Ovarian Neoplasms/genetics ; Proto-Oncogene Protein c-ets-2/genetics ; Pyrazoles/pharmacology ; Pyridazines/pharmacology ; Signal Transduction/drug effects ; Sulfonamides/pharmacology ; Telomerase/metabolism ; Transfection