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Wyszukujesz frazę ""Proto-Oncogene Proteins c-akt"" wg kryterium: Temat


Tytuł :
Brucine promotes apoptosis in cervical cancer cells (ME-180) via suppression of inflammation and cell proliferation by regulating PI3K/AKT/mTOR signaling pathway.
Autorzy :
Seshadri VD; Department of Pharmacology & Toxicology, College of Pharmacy, Prince Sattam Bin Abdul Aziz University, Al-Kharj, Saudi Arabia.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Sep; Vol. 36 (9), pp. 1841-1847. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article
MeSH Terms :
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Uterine Cervical Neoplasms*
Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Female ; Humans ; Inflammation ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction ; Strychnine/analogs & derivatives ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Cadmium induces the thymus apoptosis of pigs through ROS-dependent PTEN/PI3K/AKT signaling pathway.
Autorzy :
Yiming Z; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Zhaoyi L; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Jing L; Quality and Safety Institute of Agricultural Products, Heilongjiang Academy of Agricultural Sciences, Harbin, 150000, China.
Jinliang W; Shandong Binzhou Anim Sci & Vet Med Acad, Binzhou, 256600, People's Republic of China.
Zhiqiang S; Shandong Binzhou Anim Sci & Vet Med Acad, Binzhou, 256600, People's Republic of China.
Guangliang S; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. .
Shu L; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. .
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Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2021 Aug; Vol. 28 (29), pp. 39982-39992. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article
MeSH Terms :
Phosphatidylinositol 3-Kinases*/genetics
Phosphatidylinositol 3-Kinases*/metabolism
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Animals ; Apoptosis ; Cadmium/toxicity ; Reactive Oxygen Species ; Signal Transduction ; Swine
Czasopismo naukowe
Tytuł :
The tRNA-derived fragment 5026a inhibits the proliferation of gastric cancer cells by regulating the PTEN/PI3K/AKT signaling pathway.
Autorzy :
Zhu L; Department of Gastroenterology, The Affiliated Hospital of Ningbo University School of Medicine, Ningbo, 315020, China.; Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, 315211, China.; Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, 315041, China.
Li Z; Department of Gastroenterology, The Affiliated Hospital of Ningbo University School of Medicine, Ningbo, 315020, China.; Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, 315211, China.
Yu X; Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, 315211, China.
Ruan Y; Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, 315211, China.
Shen Y; Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, 315211, China.
Shao Y; Department of Gastroenterology, The Affiliated Hospital of Ningbo University School of Medicine, Ningbo, 315020, China.; Institute of Digestive Diseases of Ningbo University, Ningbo, 315020, China.
Zhang X; Department of Gastroenterology, The Affiliated Hospital of Ningbo University School of Medicine, Ningbo, 315020, China.; Institute of Digestive Diseases of Ningbo University, Ningbo, 315020, China.
Ye G; Department of Gastroenterology, The Affiliated Hospital of Ningbo University School of Medicine, Ningbo, 315020, China.; Institute of Digestive Diseases of Ningbo University, Ningbo, 315020, China.
Guo J; Department of Gastroenterology, The Affiliated Hospital of Ningbo University School of Medicine, Ningbo, 315020, China. .; Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, 315211, China. .; Institute of Digestive Diseases of Ningbo University, Ningbo, 315020, China. .
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Źródło :
Stem cell research & therapy [Stem Cell Res Ther] 2021 Jul 22; Vol. 12 (1), pp. 418. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Stomach Neoplasms*/genetics
Animals ; Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Mice, Nude ; PTEN Phosphohydrolase/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; RNA, Transfer ; Signal Transduction
Czasopismo naukowe
Tytuł :
Dasatinib inhibits proliferation of liver cancer cells, but activation of Akt/mTOR compromises dasatinib as a cancer drug.
Autorzy :
Liu C; Department of Biochemistry and Molecular Biology, Changzhi Medical College, Changzhi 046000, China.; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, China.
Zhu X; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, China.
Jia Y; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, China.
Chi F; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, China.
Qin K; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, China.
Pei J; Department of Biochemistry and Molecular Biology, Changzhi Medical College, Changzhi 046000, China.
Zhang C; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, China.
Mu X; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, China.
Zhang H; Department of Hematology, Affiliated Tumor Hospital of Shanxi Medical University, Taiyuan 030013, China.
Dong X; Department of General Surgery, Shanxi Bethune Hospital, Taiyuan 030032, China.
Xu J; Department of General Surgery, The First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Yu B; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, China.
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Źródło :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2021 Jul 05; Vol. 53 (7), pp. 823-836.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*/drug therapy
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/metabolism
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/drug therapy
Liver Neoplasms*/genetics
Liver Neoplasms*/metabolism
Liver Neoplasms*/pathology
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
TOR Serine-Threonine Kinases*/genetics
TOR Serine-Threonine Kinases*/metabolism
Antineoplastic Agents/*pharmacology
Cell Proliferation/*drug effects
Dasatinib/*pharmacology
Signal Transduction/*drug effects
Cell Line, Tumor ; Enzyme Activation/drug effects ; Humans ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Targeting Akt-associated microRNAs for cancer therapeutics.
Autorzy :
Adil MS; Clinical and Experimental Therapeutics, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA, United States.
Khulood D; Clinical and Experimental Therapeutics, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA, United States.
Somanath PR; Clinical and Experimental Therapeutics, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA, United States. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Jul; Vol. 189, pp. 114384. Date of Electronic Publication: 2020 Dec 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antineoplastic Agents/*administration & dosage
Drug Delivery Systems/*methods
MicroRNAs/*metabolism
Neoplasms/*drug therapy
Neoplasms/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Animals ; Drug Delivery Systems/trends ; Humans ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/genetics ; Neoplasms/genetics ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt/genetics
Czasopismo naukowe
Tytuł :
Role of PI3K/AKT Signaling Pathway in Nucleus Pulposus Cells.
Autorzy :
Xiao Q; Department of Orthopaedic Surgery, The Affiliated Lianshui People's Hospital of Kangda College of Nanjing Medical Universty, Lianshui, Jiangsu, China.
Teng Y; Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Xu C; Department of Orthopaedic Surgery, The Affiliated Lianshui People's Hospital of Kangda College of Nanjing Medical Universty, Lianshui, Jiangsu, China.
Pan W; Department of Orthopaedic Surgery, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu 223002, China.
Yang H; Department of Orthopaedic Surgery, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu 223002, China.
Zhao J; Department of Orthopaedic Surgery, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu 223002, China.
Zhou Q; Department of Orthopaedic Surgery, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu 223002, China.
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Źródło :
BioMed research international [Biomed Res Int] 2021 Jul 01; Vol. 2021, pp. 9941253. Date of Electronic Publication: 2021 Jul 01 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Nucleus Pulposus/*enzymology
Proto-Oncogene Proteins c-akt/*metabolism
Animals ; Apoptosis ; Cell Proliferation/drug effects ; Chromones ; Insulin-Like Growth Factor I/metabolism ; Morpholines ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-akt/agonists ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Digitonin-facilitated delivery of imaging probes enables single-cell analysis of AKT signalling activities in suspension cells.
Autorzy :
Wang S; Department of Chemistry, University of California, Riverside, Riverside, California 92521, USA. .
Perkins NG
Ji F
Chaudhuri R
Guo Z
Sarkar P
Shao S
Li Z
Xue M
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Źródło :
The Analyst [Analyst] 2021 Sep 07; Vol. 146 (17), pp. 5307-5315. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Phenomena*
Proto-Oncogene Proteins c-akt*/metabolism
Digitonin ; Humans ; Signal Transduction ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Akt scaffold proteins: the key to controlling specificity of Akt signaling.
Autorzy :
Bao F; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.; Center of Stomatology, The First People's Hospital of Yunnan Province, Kunming, China.; The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Hao P; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
An S; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
Yang Y; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
Liu Y; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
Hao Q; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
Ejaz M; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
Guo XX; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
Xu TR; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2021 Sep 01; Vol. 321 (3), pp. C429-C442. Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Gene Expression Regulation, Neoplastic/*drug effects
Neoplasms/*drug therapy
Phosphatidylinositol 3-Kinases/*genetics
Proto-Oncogene Proteins c-akt/*genetics
Signal Transduction/*drug effects
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Molecular Targeted Therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/genetics ; Sodium-Hydrogen Exchangers/genetics ; Sodium-Hydrogen Exchangers/metabolism ; ras GTPase-Activating Proteins/genetics ; ras GTPase-Activating Proteins/metabolism
Czasopismo naukowe
Tytuł :
Hepatotoxic effect of tramadol and O-desmethyltramadol in HepG2 cells and potential role of PI3K/AKT/mTOR.
Autorzy :
Helmy MA; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Abdalla HA; Department of Medical Biochemistry, Faculty of Medicine, Mansoura University, Mansoura, Egypt.; Department of Clinical Biochemistry and Molecular Medicine, Faculty of Medicine, Taibah University, Medina, Saudi Arabia.
Abd El Rahman HA; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Ahmed DAM; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Sep; Vol. 51 (9), pp. 1029-1037. Date of Electronic Publication: 2021 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
Proto-Oncogene Proteins c-akt*
Tramadol*/analogs & derivatives
Tramadol*/toxicity
Hep G2 Cells ; Humans ; Phosphatidylinositol 3-Kinases ; TOR Serine-Threonine Kinases
Czasopismo naukowe
Tytuł :
Ochratoxin A induces human kidney tubular epithelial cell apoptosis through regulating lipid raft/PTEN/AKT signaling pathway.
Autorzy :
Song Y; Department of Nephrology, The Second Hospital of Jilin University, Changchun, China.
Liu W; Department of Spinal Surgery, The First Hospital of Jilin University, Changchun, China.
Zhao Y; Department of Nephrology, The Second Hospital of Jilin University, Changchun, China.
Zang J; Department of Bone and Joint Surgery, The First Hospital of Jilin University, Changchun, China.
Gao H; Department of Bone and Joint Surgery, The First Hospital of Jilin University, Changchun, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Sep; Vol. 36 (9), pp. 1880-1885. Date of Electronic Publication: 2021 Jun 08.
Typ publikacji :
Journal Article
MeSH Terms :
Ochratoxins*/toxicity
Proto-Oncogene Proteins c-akt*/metabolism
Apoptosis ; Epithelial Cells/metabolism ; Humans ; Kidney/metabolism ; Membrane Microdomains/metabolism ; PTEN Phosphohydrolase ; Reactive Oxygen Species ; Signal Transduction
Czasopismo naukowe
Tytuł :
An updated patent review of Akt inhibitors (2016-present).
Autorzy :
Guo Y; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P.R. China.
Jin Y; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P.R. China.
Qu B; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P.R. China.
Zhang Y; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P.R. China.
Che J; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P.R. China.
Dong X; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P.R. China.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, P.R. China.; Cancer Center, Zhejiang University, Hangzhou, P.R. China.
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Źródło :
Expert opinion on therapeutic patents [Expert Opin Ther Pat] 2021 Sep; Vol. 31 (9), pp. 837-849. Date of Electronic Publication: 2021 May 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Design*
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins c-akt/*antagonists & inhibitors
Animals ; Drug Development ; Humans ; Immunotherapy/methods ; Neoplasms/drug therapy ; Neoplasms/enzymology ; Patents as Topic ; Proto-Oncogene Proteins c-akt/metabolism
Czasopismo naukowe
Tytuł :
Silenced fatty acid-binding protein 4 suppresses epithelial-mesenchymal transition of endometriosis via the phosphatidyl inositol 3-kinase/protein kinase B axis.
Autorzy :
Zhang Y; Department of Gynecology, the Affiliated Hospital of Chengde Medical College, Chengde, Hebei Province, China.
Hou A; Department of Gynecology, the University of Chinese Academy of Sciences Shenzhen Hospital, Shenzhen, Guangdong Province, China.
Zhuang XR; Department of Gynecology, the Affiliated Hospital of Chengde Medical College, Chengde, Hebei Province, China.
Gao XJ; Department of Gynecology, the Affiliated Hospital of Chengde Medical College, Chengde, Hebei Province, China.
Zhang GX; Department of Gynecology, the Affiliated Hospital of Chengde Medical College, Chengde, Hebei Province, China.
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Źródło :
Journal of biological regulators and homeostatic agents [J Biol Regul Homeost Agents] 2021 Aug 27; Vol. 35 (4). Date of Electronic Publication: 2021 Jul 20.
Typ publikacji :
Letter
MeSH Terms :
Endometriosis*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Epithelial-Mesenchymal Transition ; Fatty Acid-Binding Proteins/genetics ; Female ; Humans ; Neoplasm Invasiveness ; Phosphatidylinositol 3-Kinase ; Phosphatidylinositols
Opinia redakcyjna
Tytuł :
Co-targeting CDK4/6 and AKT with endocrine therapy prevents progression in CDK4/6 inhibitor and endocrine therapy-resistant breast cancer.
Autorzy :
Alves CL; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark. .
Ehmsen S; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Department of Oncology, Institute of Clinical Research, Odense University Hospital, Odense, Denmark.
Terp MG; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Portman N; Garvan Institute of Medical Research, Sydney, NSW, Australia.; St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales Sydney, Sydney, NSW, Australia.
Tuttolomondo M; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Gammelgaard OL; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Hundebøl MF; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Kaminska K; Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.
Johansen LE; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Bak M; Department of Pathology, Sydvestjysk Sygehus, Esbjerg, Denmark.
Honeth G; Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.
Bosch A; Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.
Lim E; Garvan Institute of Medical Research, Sydney, NSW, Australia.; St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales Sydney, Sydney, NSW, Australia.
Ditzel HJ; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark. .; Department of Oncology, Institute of Clinical Research, Odense University Hospital, Odense, Denmark. .; Academy of Geriatric Cancer Research (AgeCare), Odense University Hospital, Odense, Denmark. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 25; Vol. 12 (1), pp. 5112. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*drug therapy
Cyclin-Dependent Kinase 4/*antagonists & inhibitors
Cyclin-Dependent Kinase 6/*antagonists & inhibitors
Fulvestrant/*administration & dosage
Protein Kinase Inhibitors/*administration & dosage
Proto-Oncogene Proteins c-akt/*metabolism
Breast Neoplasms/enzymology ; Breast Neoplasms/genetics ; Cell Line, Tumor ; Cyclin-Dependent Kinase 4/genetics ; Cyclin-Dependent Kinase 4/metabolism ; Cyclin-Dependent Kinase 6/genetics ; Cyclin-Dependent Kinase 6/metabolism ; Disease Progression ; Drug Resistance, Neoplasm ; Drug Therapy, Combination ; Female ; Humans ; Molecular Targeted Therapy ; Proto-Oncogene Proteins c-akt/genetics
Czasopismo naukowe
Tytuł :
[Procyanidin B2 protects neurons from cypermethrin-induced oxidative stress through the P13K/Akt/Nrf2 signaling pathway].
Autorzy :
Zhou L; School of Public Health, Bengbu Medical College, Bengbu 233030, China.
Chang J; Scientific Research Center, Bengbu Medical College, Bengbu 233030, China.
Gao Y; School of Public Health, Bengbu Medical College, Bengbu 233030, China.
Wang C; School of Public Health, Bengbu Medical College, Bengbu 233030, China.
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Źródło :
Nan fang yi ke da xue xue bao = Journal of Southern Medical University [Nan Fang Yi Ke Da Xue Xue Bao] 2021 Aug 20; Vol. 41 (8), pp. 1158-1164.
Typ publikacji :
Journal Article
MeSH Terms :
NF-E2-Related Factor 2*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Animals ; Apoptosis ; Biflavonoids ; Catechin ; Mice ; Mice, Inbred C57BL ; Neurons/metabolism ; Oxidative Stress ; Proanthocyanidins ; Pyrethrins ; Reactive Oxygen Species ; Signal Transduction
Czasopismo naukowe
Tytuł :
Inhibition of Cell Proliferation and Metastasis by Scutellarein Regulating PI3K/Akt/NF-κB Signaling through PTEN Activation in Hepatocellular Carcinoma.
Autorzy :
Ha SE; Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Gazwa Campus, 501 Jinju-daero, Jinju 52828, Korea.
Kim SM; Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Gazwa Campus, 501 Jinju-daero, Jinju 52828, Korea.
Vetrivel P; Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Gazwa Campus, 501 Jinju-daero, Jinju 52828, Korea.
Kim HH; Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Gazwa Campus, 501 Jinju-daero, Jinju 52828, Korea.
Bhosale PB; Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Gazwa Campus, 501 Jinju-daero, Jinju 52828, Korea.
Heo JD; Biological Resources Research Group, Gyeongnam Department of Environment Toxicology and Chemistry, Korea Institute of Toxicology, 17 Jegok-gil, Jinju 52834, Korea.
Lee HJ; Biological Resources Research Group, Gyeongnam Department of Environment Toxicology and Chemistry, Korea Institute of Toxicology, 17 Jegok-gil, Jinju 52834, Korea.
Kim GS; Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Gazwa Campus, 501 Jinju-daero, Jinju 52828, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 17; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article
MeSH Terms :
Apigenin/*pharmacology
Carcinoma, Hepatocellular/*drug therapy
Gene Expression Regulation, Neoplastic/*drug effects
NF-kappa B/*metabolism
PTEN Phosphohydrolase/*metabolism
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Movement ; Cell Proliferation ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; NF-kappa B/genetics ; PTEN Phosphohydrolase/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
P2Y2 promotes fibroblasts activation and skeletal muscle fibrosis through AKT, ERK, and PKC.
Autorzy :
Chen M; Department of Otorhinolaryngology, Changhai Hospital of Navy Medical University, 168 Changhai Road, Shanghai, 200433, China.
Chen H; Department of Otorhinolaryngology, The First Affiliate Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Gu Y; Department of Otorhinolaryngology, Jingjiang People's Hospital, Jingjiang, 214500, Jiangsu, China.
Sun P; Department of Otorhinolaryngology, The First Affiliate Hospital of Soochow University, Suzhou, 215006, Jiangsu, China.
Sun J; Department of Otorhinolaryngology, Changhai Hospital of Navy Medical University, 168 Changhai Road, Shanghai, 200433, China.
Yu H; Department of Otorhinolaryngology, Changhai Hospital of Navy Medical University, 168 Changhai Road, Shanghai, 200433, China.
Zheng H; Department of Otorhinolaryngology, Changhai Hospital of Navy Medical University, 168 Changhai Road, Shanghai, 200433, China. .
Chen D; Department of Otorhinolaryngology, The First Affiliate Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China. .
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Źródło :
BMC musculoskeletal disorders [BMC Musculoskelet Disord] 2021 Aug 11; Vol. 22 (1), pp. 680. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji :
Journal Article
MeSH Terms :
Proto-Oncogene Proteins c-akt*/metabolism
Extracellular Signal-Regulated MAP Kinases/*metabolism
Muscle, Skeletal/*pathology
Protein Kinase C/*metabolism
Receptors, Purinergic P2Y2/*metabolism
Animals ; Cells, Cultured ; Fibroblasts/pathology ; Fibrosis ; Mice ; Mice, Knockout ; Transforming Growth Factor beta1/pharmacology
Czasopismo naukowe
Tytuł :
Sargahydroquinoic acid (SHQA) suppresses cellular senescence through Akt/mTOR signaling pathway.
Autorzy :
Cao L; Institute of Marine Life Science, Pukyong National University, Daeyeon 3-dong, Nam-gu, Busan 608-737, South Korea. Electronic address: .
Lee SG; Department of Food Science and Nutrition, Pukyong National University, Daeyeon 3-dong, Nam-gu, Busan 608-737, South Korea. Electronic address: .
Park SH; Department of Biomedical Engineering, Pukyong National University, Daeyeon 3-dong, Nam-gu, Busan 608-737, South Korea. Electronic address: .
Kim HR; Department of Food Science and Nutrition, Pukyong National University, Daeyeon 3-dong, Nam-gu, Busan 608-737, South Korea. Electronic address: .
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Źródło :
Experimental gerontology [Exp Gerontol] 2021 Aug; Vol. 151, pp. 111406. Date of Electronic Publication: 2021 May 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelial Cells*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Alkenes ; Benzoquinones ; Cells, Cultured ; Cellular Senescence ; Humans ; Hydrogen Peroxide ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Tumor Suppressor Protein p53
Czasopismo naukowe
Tytuł :
Polycystin-1 regulates cardiomyocyte mitophagy.
Autorzy :
Ramírez-Sagredo A; Advanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas y Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Quiroga C; Advanced Center for Chronic Diseases (ACCDiS), División de Enfermedades Cardiovasculares, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Garrido-Moreno V; Advanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas y Facultad de Medicina, Universidad de Chile, Santiago, Chile.
López-Crisosto C; Advanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas y Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Advanced Center for Chronic Diseases (ACCDiS), División de Enfermedades Cardiovasculares, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Leiva-Navarrete S; Advanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas y Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Autophagy Research Center, Universidad de Chile, Santiago, Chile.; Network for the Study of High-lethality Cardiopulmonary Diseases (REECPAL), Universidad de Chile, Santiago, Chile.
Norambuena-Soto I; Advanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas y Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Ortiz-Quintero J; Advanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas y Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Departamento de Bioanálisis e Inmunología, Escuela de Microbiología, Facultad de Ciencias, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras.
Díaz-Vesga MC; Advanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas y Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Programa de Fisiología y Biofísica, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Grupo de Investigación en Ciencias Básicas y Clínicas de la Salud, Pontificia Universidad Javeriana de Cali, Cali, Colombia.
Perez W; Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, USA.
Hendrickson T; Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, USA.; Texas A&M MD/PhD Program, Texas A&M Health Science Center, College Station, TX, USA.
Parra V; Advanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas y Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Autophagy Research Center, Universidad de Chile, Santiago, Chile.; Network for the Study of High-lethality Cardiopulmonary Diseases (REECPAL), Universidad de Chile, Santiago, Chile.
Pedrozo Z; Advanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas y Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Network for the Study of High-lethality Cardiopulmonary Diseases (REECPAL), Universidad de Chile, Santiago, Chile.; Programa de Fisiología y Biofísica, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Altamirano F; Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, USA.; Department of Cardiothoracic Surgery, Weill Cornell Medical College, Cornell University, Ithaca, NY, USA.
Chiong M; Advanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas y Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Lavandero S; Advanced Center of Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas y Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Corporación Centro de Estudios Científicos de las Enfermedades Crónicas (CECEC), Santiago, Chile.; Department of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX, USA.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Aug; Vol. 35 (8), pp. e21796.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Forkhead Box Protein O1/*metabolism
Mitophagy/*physiology
Myocytes, Cardiac/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
TRPP Cation Channels/*metabolism
Animals ; Animals, Newborn ; Forkhead Box Protein O1/genetics ; Gene Expression Regulation/physiology ; Gene Silencing ; Mitochondria/metabolism ; Mitophagy/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Rats ; Rats, Sprague-Dawley ; TRPP Cation Channels/genetics
Czasopismo naukowe
Tytuł :
Sortilin regulates keratinocyte proliferation and apoptosis through the PI3K-AKT signaling pathway.
Autorzy :
Zhang R; Department of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou 215004, China.
Wang YH; Department of Cell Biology, School of Biology and Basic Medical, Soochow University, No. 199 Renai Road, Suzhou 215123, China.
Shi X; Department of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou 215004, China.
Ji J; Department of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou 215004, China.
Zhan FQ; Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, 215004, China.
Leng H; Department of Dermatology, The Second Affiliated Hospital of Soochow University, Su Zhou 215004, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Aug 01; Vol. 278, pp. 119630. Date of Electronic Publication: 2021 May 15.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Cell Proliferation*
Adaptor Proteins, Vesicular Transport/*pharmacology
Keratinocytes/*pathology
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Psoriasis/*pathology
Adolescent ; Adult ; Aged ; Animals ; Case-Control Studies ; Female ; Gene Expression Regulation ; Humans ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Middle Aged ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Psoriasis/drug therapy ; Psoriasis/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Pseudogene ANXA2P2 knockdown shows tumor-suppressive function by inhibition of the PI3K/PKB pathway in glioblastoma cells.
Autorzy :
Ni H; Department of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Zhi R; Department of Gastroenterology, Lianshui County People's Hospital Affiliated to Kangda College of Nanjing Medical University, Huai'an, China.
Zuo J; Department of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Liu W; Department of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Xie P; Department of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Zhi Z; Department of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
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Źródło :
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2021 Aug; Vol. 35 (8), pp. e22824. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Knockdown Techniques*
Genes, Tumor Suppressor*
Glioblastoma*/genetics
Glioblastoma*/metabolism
Pseudogenes*
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Cell Line, Tumor ; Humans ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics
Czasopismo naukowe

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