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Wyszukujesz frazę ""Proto-Oncogene Proteins c-akt"" wg kryterium: Temat


Tytuł:
Effects of ambient PM 2.5 on development of psoriasiform inflammation through KRT17-dependent activation of AKT/mTOR/HIF-1α pathway.
Autorzy:
Wang X; Department of Occupational Health and Environmental Health, Hebei Medical University, Shijiazhuang 050017, People's Republic of China; Department of Dermatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, People's Republic of China.
Niu L; Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, People's Republic of China.
Kang A; Department of Occupational Health and Environmental Health, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Pang Y; Department of Toxicology, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Zhang Y; Department of Toxicology, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Wang W; Department of Dermatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, People's Republic of China.
Zhang Y; Department of Dermatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, People's Republic of China.
Huang X; Department of Occupational Health and Environmental Health, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Liu Q; Department of Toxicology, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Geng Z; Department of Occupational Health and Environmental Health, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
He L; Department of Occupational Health and Environmental Health, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.
Niu Y; Department of Occupational Health and Environmental Health, Hebei Medical University, Shijiazhuang 050017, People's Republic of China; Hebei Key Laboratory of Environment and Human Health, Shijiazhuang 050017, People's Republic of China. Electronic address: .
Zhang R; Department of Toxicology, Hebei Medical University, Shijiazhuang 050017, People's Republic of China; Hebei Key Laboratory of Environment and Human Health, Shijiazhuang 050017, People's Republic of China. Electronic address: .
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Źródło:
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2022 Sep 15; Vol. 243, pp. 114008. Date of Electronic Publication: 2022 Aug 24.
Typ publikacji:
Journal Article; Randomized Controlled Trial, Veterinary
MeSH Terms:
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Psoriasis*/chemically induced
Psoriasis*/genetics
Psoriasis*/pathology
Animals ; Imiquimod/toxicity ; Inflammation/chemically induced ; Male ; Mice ; Mice, Inbred C57BL ; Particulate Matter/toxicity ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Vascular Endothelial Growth Factor A
Czasopismo naukowe
Tytuł:
ADAM33 Silencing Inhibits Vascular Smooth Muscle Cell Migration and Regulates Cytokine Secretion in Airway Vascular Remodeling via the PI3K/AKT/mTOR Pathway.
Autorzy:
Yan F; School of Public Health, Xinjiang Medical University, Urumqi 830011, China.; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Respiratory Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Hu X; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Respiratory Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
He L; Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Jiao K; School of Public Health, Xinjiang Medical University, Urumqi 830011, China.
Hao Y; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Respiratory Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Wang J; Department of Respiratory Medicine, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, China.
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Źródło:
Canadian respiratory journal [Can Respir J] 2022 Aug 31; Vol. 2022, pp. 8437348. Date of Electronic Publication: 2022 Aug 31 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Asthma*/genetics
Asthma*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Proto-Oncogene Proteins c-akt*/pharmacology
ADAM Proteins/genetics ; ADAM Proteins/metabolism ; ADAM Proteins/pharmacology ; Airway Remodeling ; Cell Movement ; Cells, Cultured ; Cytokines ; Humans ; Muscle, Smooth, Vascular/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphatidylinositol 3-Kinase/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositol 3-Kinases/pharmacology ; RNA, Small Interfering/metabolism ; RNA, Small Interfering/pharmacology ; TOR Serine-Threonine Kinases/metabolism ; TOR Serine-Threonine Kinases/pharmacology ; Vascular Remodeling
Czasopismo naukowe
Tytuł:
Effect of AKT silence on malignant biological behavior of renal cell carcinoma cells.
Autorzy:
Li Z; Department of Urology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Nong D; Department of Urology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Li B; Department of Urology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Wang H; Department of Urology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Li C; Department of Urology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Chen Z; Department of Urology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Li X; Department of Urology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Huang G; Department of Urology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Lin J; Department of Urology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Hao N; Department of Urology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Li W; Department of Urology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China. liwei95_.
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Źródło:
BMC urology [BMC Urol] 2022 Aug 22; Vol. 22 (1), pp. 129. Date of Electronic Publication: 2022 Aug 22.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Renal Cell*/pathology
Kidney Neoplasms*/pathology
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Gene Silencing ; Humans ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism
Czasopismo naukowe
Tytuł:
Interleukin-8 Regulates the Autophagy and Apoptosis in Gastric Cancer Cells via Regulating PI3K/Akt Signaling Pathway.
Autorzy:
Yu L; Department of General Surgery, Changshu No. 2 People's Hospital, China.
Zhou G; Department of General Surgery, Changshu No. 2 People's Hospital, China.
Shi Z; Department of General Surgery, Changshu No. 2 People's Hospital, China.
Guo J; Department of General Surgery, Changshu No. 2 People's Hospital, China.
Yu S; Department of General Surgery, Changshu No. 2 People's Hospital, China.
Yu C; Department of General Surgery, Changshu No. 2 People's Hospital, China.
Shen C; Department of General Surgery, Changshu No. 2 People's Hospital, China.
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Źródło:
Disease markers [Dis Markers] 2022 Aug 11; Vol. 2022, pp. 7300987. Date of Electronic Publication: 2022 Aug 11 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*/genetics
Autophagy*/genetics
Interleukin-8*/genetics
Interleukin-8*/metabolism
Phosphatidylinositol 3-Kinases*/genetics
Phosphatidylinositol 3-Kinases*/metabolism
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Stomach Neoplasms*/genetics
Stomach Neoplasms*/metabolism
Autophagy-Related Protein 5/genetics ; Beclin-1/genetics ; Beclin-1/metabolism ; CRISPR-Associated Proteins/pharmacology ; Humans ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Proto-Oncogene Proteins c-bcl-2/pharmacology ; Signal Transduction ; bcl-2-Associated X Protein/pharmacology
Czasopismo naukowe
Tytuł:
Neuroprotection of Triptolide against Amyloid-Beta1-42-induced toxicity via the Akt/mTOR/p70S6K-mediated Autophagy Pathway.
Autorzy:
Xu P; Tianjin University of Traditional Chinese Medicine, School of Integrative Medicine, 10 Poyanghu Road, Jinghai District, Tianjin 301617, China.
Wu Z; Tianjin University of Traditional Chinese Medicine, School of Integrative Medicine, 10 Poyanghu Road, Jinghai District, Tianjin 301617, China.
Peng Y; Tianjin University of Traditional Chinese Medicine, School of Integrative Medicine, 10 Poyanghu Road, Jinghai District, Tianjin 301617, China.
Gao J; Tianjin University of Traditional Chinese Medicine, School of Integrative Medicine, 10 Poyanghu Road, Jinghai District, Tianjin 301617, China.
Zheng F; Tianjin University of Traditional Chinese Medicine, School of Integrative Medicine, 10 Poyanghu Road, Jinghai District, Tianjin 301617, China.
Tan J; Tianjin University of Traditional Chinese Medicine, School of Integrative Medicine, 10 Poyanghu Road, Jinghai District, Tianjin 301617, China.
Xu J; Tianjin Medical University General Hospital, Department of Neurology, 154 Anshan Road, Heping District, Tianjin 300052, China.
Wang T; Tianjin University of Traditional Chinese Medicine, School of Integrative Medicine, 10 Poyanghu Road, Jinghai District, Tianjin 301617, China.
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Źródło:
Anais da Academia Brasileira de Ciencias [An Acad Bras Cienc] 2022 Aug 08; Vol. 94 (2), pp. e20210938. Date of Electronic Publication: 2022 Aug 08 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*
Proto-Oncogene Proteins c-akt*/metabolism
Proto-Oncogene Proteins c-akt*/pharmacology
Animals ; Autophagy ; Diterpenes ; Epoxy Compounds ; Humans ; Mammals ; Neuroprotection ; Phenanthrenes ; Rats ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Ribosomal Protein S6 Kinases, 70-kDa/pharmacology ; TOR Serine-Threonine Kinases/metabolism ; TOR Serine-Threonine Kinases/pharmacology
Czasopismo naukowe
Tytuł:
AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay.
Autorzy:
Cho H; Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA; Center for RNA Biology, University of Rochester, Rochester, NY 14642, USA.
Abshire ET; Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA; Center for RNA Biology, University of Rochester, Rochester, NY 14642, USA.
Popp MW; Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA; Center for RNA Biology, University of Rochester, Rochester, NY 14642, USA.
Pröschel C; Department of Biomedical Genetics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA; Stem Cell and Regenerative Medicine Institute, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA.
Schwartz JL; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA; Stem Cell Program, University of California, San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, USA.
Yeo GW; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA; Stem Cell Program, University of California, San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, USA.
Maquat LE; Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA; Center for RNA Biology, University of Rochester, Rochester, NY 14642, USA. Electronic address: lynne_.
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Źródło:
Molecular cell [Mol Cell] 2022 Aug 04; Vol. 82 (15), pp. 2779-2796.e10. Date of Electronic Publication: 2022 Jun 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Nonsense Mediated mRNA Decay*
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Animals ; Codon, Nonsense/genetics ; Exons/genetics ; Mammals/metabolism ; RNA Helicases/genetics ; RNA Helicases/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
A κ-OR Agonist Protects the Endothelial Function Impaired by Hyperuricemia Through Regulating the Akt/eNOS Signal Pathway.
Autorzy:
Zheng Q; Department of Geriatrics, The First Affiliated Hospital of Chengdu Medical College, Sichuan, Chengdu, China.
Wu Q; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Chengdu Medical College, Sichuan, China. .
Yang H; Department of Cardiovascular Medicine, The First Affiliated Hospital of Chengdu Medical College, Sichuan, Chengdu, China.
Chen Q; Department of Cardiovascular Medicine, The First Affiliated Hospital of Chengdu Medical College, Sichuan, Chengdu, China.
Li X; Department of Cardiovascular Medicine, The First Affiliated Hospital of Chengdu Medical College, Sichuan, Chengdu, China.
Guo J; Department of Cardiovascular Medicine, The First Affiliated Hospital of Chengdu Medical College, Sichuan, Chengdu, China.
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Źródło:
Probiotics and antimicrobial proteins [Probiotics Antimicrob Proteins] 2022 Aug; Vol. 14 (4), pp. 751-759. Date of Electronic Publication: 2022 May 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hyperuricemia*/drug therapy
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer/pharmacology ; Animals ; Endothelial Cells/metabolism ; Intercellular Adhesion Molecule-1/genetics ; Intercellular Adhesion Molecule-1/pharmacology ; Nitric Oxide Synthase Type III/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid, kappa/metabolism ; Signal Transduction ; Tumor Necrosis Factor-alpha/genetics
Czasopismo naukowe
Tytuł:
In vitro assessment of roles of PPP1R14B in cervical and endometrial cancer.
Autorzy:
Xiang N; Department of Obstetrics and Gynecology, Shandong Provincial Third Hospital, Jinan 250031, China.
Chen T; Department of Clinical Laboratory, Jinan Maternity and Child Care Hospital, Jinan 250001, China.
Zhao X; Department of Obstetrics, The Third People's Hospital of Jinan, Jinan 250132, China.
Zhao M; Department of Obstetrics and Gynecology, Shandong Provincial Third Hospital, Jinan 250031, China. Electronic address: zm84_.
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Źródło:
Tissue & cell [Tissue Cell] 2022 Aug; Vol. 77, pp. 101845. Date of Electronic Publication: 2022 May 31.
Typ publikacji:
Journal Article
MeSH Terms:
Endometrial Neoplasms*/genetics
Endometrial Neoplasms*/metabolism
Endometrial Neoplasms*/pathology
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Apoptosis/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Female ; Humans ; Protein Phosphatase 1/genetics
Czasopismo naukowe
Tytuł:
The PI3K/AKT signaling pathway in cancer: Molecular mechanisms and possible therapeutic interventions.
Autorzy:
Khezri MR; Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
Jafari R; Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.
Yousefi K; Department of Molecular and Cellular Pharmacology, University of Miami-Miller School of Medicine, Miami, FL, USA.
Zolbanin NM; Experimental and Applied Pharmaceutical Sciences Research Center, Urmia University of Medical Sciences, Urmia, Iran; Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran. Electronic address: .
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Źródło:
Experimental and molecular pathology [Exp Mol Pathol] 2022 Aug; Vol. 127, pp. 104787. Date of Electronic Publication: 2022 May 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neoplasms*/genetics
Neoplasms*/therapy
Phosphatidylinositol 3-Kinases*/genetics
Phosphatidylinositol 3-Kinases*/metabolism
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Signal Transduction*
Cell Proliferation/genetics ; Humans
Czasopismo naukowe
Tytuł:
Corn oligopeptides inhibit Akt/NF-κB signaling pathway and inflammatory factors to ameliorate CCl 4 -induced hepatic fibrosis in mice.
Autorzy:
Feng XW; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.
Cheng QL; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.
Fang L; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.
Liu WY; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.; Engineering Laboratory for Agro Biomass Recycling & Valorizing, College of Engineering, China Agricultural University, Beijing, People's Republic of China.
Liu LW; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.; College of Food Science, Northeast Agricultural University, Harbin, People's Republic of China.
Sun CQ; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.; College of Food Science, Northeast Agricultural University, Harbin, People's Republic of China.
Lu ZH; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.
Li GM; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.
Gu RZ; Beijing Engineering Research Center of Protein and Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, People's Republic of China.
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Źródło:
Journal of food biochemistry [J Food Biochem] 2022 Aug; Vol. 46 (8), pp. e14162. Date of Electronic Publication: 2022 Apr 11.
Typ publikacji:
Journal Article
MeSH Terms:
NF-kappa B*/genetics
NF-kappa B*/metabolism
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Animals ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/drug therapy ; Mice ; Oligopeptides/pharmacology ; Signal Transduction ; Zea mays/metabolism
Czasopismo naukowe
Tytuł:
The insulin receptor family in the heart: new light on old insights.
Autorzy:
Clerk A; School of Biological Sciences, University of Reading, Reading, U.K.
Sugden PH; School of Biological Sciences, University of Reading, Reading, U.K.
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Źródło:
Bioscience reports [Biosci Rep] 2022 Jul 29; Vol. 42 (7).
Typ publikacji:
Journal Article; Review
MeSH Terms:
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Receptor, Insulin*/genetics
Receptor, Insulin*/metabolism
Insulin/metabolism ; Myocytes, Cardiac/metabolism ; Phosphorylation ; Signal Transduction
Czasopismo naukowe
Tytuł:
Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer.
Autorzy:
Kubota Y; Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan.
Fujioka Y; Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, Shinagawa-ku, Tokyo, Japan.; Division of Biological Molecular Mechanisms, Institute for Genetic Medicine, Hokkaido University, Sapporo, 060-0815, Japan.
Patil A; Laboratory of Functional Analysis In Silico, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan.; Combinatics Inc., Chiba, Japan.
Takagi Y; Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan.
Matsubara D; Molecular Pathology Laboratory, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan.
Iijima M; Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, Shinagawa-ku, Tokyo, Japan.
Momose I; Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, Shinagawa-ku, Tokyo, Japan.
Naka R; Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan.
Nakai K; Laboratory of Functional Analysis In Silico, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan.
Noda NN; Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, Shinagawa-ku, Tokyo, Japan.; Division of Biological Molecular Mechanisms, Institute for Genetic Medicine, Hokkaido University, Sapporo, 060-0815, Japan.
Takekawa M; Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan. .
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Źródło:
Nature communications [Nat Commun] 2022 Jul 13; Vol. 13 (1), pp. 4063. Date of Electronic Publication: 2022 Jul 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neoplasms*/metabolism
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Humans ; MAP Kinase Kinase 1/genetics ; MAP Kinase Signaling System/genetics ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł:
PD-L1 regulates cell proliferation and apoptosis in acute myeloid leukemia by activating PI3K-AKT signaling pathway.
Autorzy:
Wang F; Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.; South Sichuan Institute of Translational Medicine, Luzhou, China.
Yang L; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.; South Sichuan Institute of Translational Medicine, Luzhou, China.
Xiao M; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.; South Sichuan Institute of Translational Medicine, Luzhou, China.
Zhang Z; Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.; South Sichuan Institute of Translational Medicine, Luzhou, China.
Shen J; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.; South Sichuan Institute of Translational Medicine, Luzhou, China.
Anuchapreeda S; Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.; Research Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, Thailand.
Tima S; Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.; Research Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, Thailand.
Chiampanichayakul S; Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand. .; Research Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, Thailand. .
Xiao Z; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China. .; South Sichuan Institute of Translational Medicine, Luzhou, China. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jul 06; Vol. 12 (1), pp. 11444. Date of Electronic Publication: 2022 Jul 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
B7-H1 Antigen*/metabolism
Leukemia, Myeloid, Acute*/genetics
Leukemia, Myeloid, Acute*/metabolism
Leukemia, Myeloid, Acute*/pathology
Phosphatidylinositol 3-Kinases*/genetics
Phosphatidylinositol 3-Kinases*/metabolism
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Apoptosis/genetics ; Cell Proliferation/physiology ; Humans ; Programmed Cell Death 1 Receptor/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł:
Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development.
Autorzy:
Page N; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
Wappett M; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
O'Dowd CR; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
O'Rourke M; Amphista Therapeutics, BioCity, Bo'Ness Rd, Newhouse, Chapelhall, Motherwell, ML1 5UH, UK.
Gavory G; Ridgeline Therapeutics GmbH, Technologiepark, Hochbergerstrasse 60C, 4057, Basel, Switzerland.
Zhang L; Shenyang University of Chemical Technology, Shenyang, China.
Rountree JSS; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
Jordan L; Globachem, Alderley Park, 2 BioHub, Mereside, Macclesfield, SK10 4TG, UK.
Barker O; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
Gibson H; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
Boyd C; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
Feutren-Burton S; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
McLean E; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
Trevitt G; Sygnature Discovery, BioCity, Pennyfoot Street, Nottingham, NG1 1GR, UK.
Harrison T; Almac Discovery Ltd, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK. .; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, BT9 7AE, Northern Ireland, UK. .
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Źródło:
Scientific reports [Sci Rep] 2022 Sep 20; Vol. 12 (1), pp. 15715. Date of Electronic Publication: 2022 Sep 20.
Typ publikacji:
Journal Article
MeSH Terms:
Phosphatidylinositol 3-Kinases*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Angiogenesis Inhibitors ; Humans ; Isoenzymes ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Serine ; Tamoxifen ; Threonine
Czasopismo naukowe
Tytuł:
Synthesis, Molecular Docking, In Vitro and In Vivo Studies of Novel Dimorpholinoquinazoline-Based Potential Inhibitors of PI3K/Akt/mTOR Pathway.
Autorzy:
Zapevalova MV; Department of Organic Chemistry, Nizhny Novgorod State University, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia.
Shchegravina ES; Department of Organic Chemistry, Nizhny Novgorod State University, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia.; N.D. Zelinsky Insitute of Organic Chemistry RAS, Leninsky Prospect 47, 119991 Moscow, Russia.
Fonareva IP; Department of Organic Chemistry, Nizhny Novgorod State University, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia.
Salnikova DI; Department of Experimental Tumor Biology, Blokhin N.N. National Medical Research Center of Oncology, Kashirskoye Sh. 24, 115522 Moscow, Russia.
Sorokin DV; Department of Experimental Tumor Biology, Blokhin N.N. National Medical Research Center of Oncology, Kashirskoye Sh. 24, 115522 Moscow, Russia.
Scherbakov AM; Department of Experimental Tumor Biology, Blokhin N.N. National Medical Research Center of Oncology, Kashirskoye Sh. 24, 115522 Moscow, Russia.
Maleev AA; Department of Organic Chemistry, Nizhny Novgorod State University, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia.
Ignatov SK; Department of Organic Chemistry, Nizhny Novgorod State University, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia.
Grishin ID; Department of Organic Chemistry, Nizhny Novgorod State University, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia.
Kuimov AN; A.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Leninskye Gory, House 1, Building 40, 119992 Moscow, Russia.
Konovalova MV; Department of Immunology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Svirshchevskaya EV; Department of Immunology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Fedorov AY; Department of Organic Chemistry, Nizhny Novgorod State University, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia.; N.D. Zelinsky Insitute of Organic Chemistry RAS, Leninsky Prospect 47, 119991 Moscow, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 17; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 17.
Typ publikacji:
Journal Article
MeSH Terms:
Phosphatidylinositol 3-Kinases*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Cell Line, Tumor ; Cell Proliferation ; Molecular Docking Simulation ; Protein Kinase Inhibitors/pharmacology ; Quinazolines/pharmacology ; Reactive Oxygen Species ; TOR Serine-Threonine Kinases/metabolism ; Triazines/pharmacology ; Urea
Czasopismo naukowe
Tytuł:
Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling.
Autorzy:
Mishra S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India.
Cosentino C; The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Tamta AK; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India.
Khan D; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India.
Srinivasan S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India.
Ravi V; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India.
Abbotto E; Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Genoa, Italy.
Arathi BP; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India.
Kumar S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India.
Jain A; Centre for BioSystems Science and Engineering, Indian Institute of Science, Bengaluru, India.
Ramaian AS; Department of Biotechnology, Anna University, Chennai, India.
Kizkekra SM; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India.
Rajagopal R; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India.
Rao S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India.
Krishna S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India.
Asirvatham-Jeyaraj N; Department of Biotechnology, Indian Institute of Technology, Chennai, India.
Haggerty ER; The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Silberman DM; Centro de Estudios Farmacologicos y Botanicos (CEFYBO-CONICET), Catedra de Farmacologia, Facultad de Medicina, UBA, Buenos Aires, Argentina.
Kurland IJ; Albert Einstein College of Medicine, Bronx, NY, USA.
Veeranna RP; Department of Biochemistry, CSIR- Central Food Technological Research Institute, Mysuru, India.
Jayavelu T; Department of Biotechnology, Anna University, Chennai, India.
Bruzzone S; Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Genoa, Italy.
Mostoslavsky R; The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA. .
Sundaresan NR; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India. .
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Źródło:
Nature communications [Nat Commun] 2022 Sep 15; Vol. 13 (1), pp. 5415. Date of Electronic Publication: 2022 Sep 15.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Sirtuins*/genetics
Sirtuins*/metabolism
Animals ; Chromatin ; Glucocorticoids/pharmacology ; Mammals/metabolism ; Mice ; Muscle Fibers, Skeletal/metabolism ; Muscular Atrophy/chemically induced ; Muscular Atrophy/metabolism ; Muscular Atrophy/prevention & control ; Phosphatidylinositol 3-Kinases/metabolism ; Somatomedins/metabolism ; Transcription Factors
Czasopismo naukowe
Tytuł:
Hyperactive Akt1 Signaling Increases Tumor Progression and DNA Repair in Embryonal Rhabdomyosarcoma RD Line and Confers Susceptibility to Glycolysis and Mevalonate Pathway Inhibitors.
Autorzy:
Codenotti S; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Zizioli D; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Mignani L; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Rezzola S; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Tabellini G; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Parolini S; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Giacomini A; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Asperti M; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Poli M; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Mandracchia D; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Vezzoli M; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Bernardi S; Department of Clinical and Experimental Sciences, ASST Spedali Civili di Brescia, University of Brescia, 25123 Brescia, Italy.
Russo D; Department of Clinical and Experimental Sciences, ASST Spedali Civili di Brescia, University of Brescia, 25123 Brescia, Italy.
Mitola S; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Monti E; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Triggiani L; Radiation Oncology Department, ASST Spedali Civili di Brescia, University of Brescia, 25123 Brescia, Italy.
Tomasini D; Radiation Oncology Department, ASST Spedali Civili di Brescia, University of Brescia, 25123 Brescia, Italy.
Gastaldello S; Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.; Precision Medicine Research Center, School of Pharmacy, Binzhou Medical University, Laishan District, Guanhai Road 346, Yantai 264003, China.
Cassandri M; Department of Hematology and Oncology, Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.; Department of Radiotherapy, Policlinico Umberto I, 'Sapienza' University of Rome, 00161 Rome, Italy.
Rota R; Department of Hematology and Oncology, Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Marampon F; Department of Radiotherapy, Policlinico Umberto I, 'Sapienza' University of Rome, 00161 Rome, Italy.
Fanzani A; Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
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Źródło:
Cells [Cells] 2022 Sep 14; Vol. 11 (18). Date of Electronic Publication: 2022 Sep 14.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Rhabdomyosarcoma, Embryonal*/drug therapy
Animals ; Child ; DNA/metabolism ; DNA Repair ; DNA-Activated Protein Kinase/genetics ; Deoxyglucose ; Doxorubicin/pharmacology ; Glucose ; Glycolysis ; Hexokinase/metabolism ; Histones/metabolism ; Humans ; Ki-67 Antigen/metabolism ; Lovastatin ; MTOR Inhibitors ; Mammals/metabolism ; Mevalonic Acid ; Oxidoreductases/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositols ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases/metabolism ; Zebrafish/genetics
Czasopismo naukowe
Tytuł:
Therapeutic Effects of Saponins for the Prevention and Treatment of Cancer by Ameliorating Inflammation and Angiogenesis and Inducing Antioxidant and Apoptotic Effects in Human Cells.
Autorzy:
Khan MI; Department of Biotechnology, Faculty of Biomedical and Life Sciences, Kohsar University, Murree 47150, Pakistan.
Karima G; Department of Bionanotechnology, Graduate School, Hanyang University, Seoul 04763, Korea.
Khan MZ; Department of Biotechnology, Chonnam National University, Yeosu 59626, Korea.
Shin JH; Department of Biotechnology, Chonnam National University, Yeosu 59626, Korea.
Kim JD; Department of Biotechnology, Chonnam National University, Yeosu 59626, Korea.; Research Center on Anti-Obesity and Health Care, Chonnam National University, Yeosu 59626, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 14; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 14.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Saponins*/pharmacology
Saponins*/therapeutic use
Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/therapeutic use ; Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Caspase 3/metabolism ; Endothelial Cells/metabolism ; HEK293 Cells ; Humans ; Inflammation/drug therapy ; Interleukin-6/metabolism ; Mammals/metabolism ; NF-kappa B/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Reactive Oxygen Species/metabolism ; Tea ; Tumor Necrosis Factor-alpha/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł:
UBE2T regulates epithelial-mesenchymal transition through the PI3K-AKT pathway and plays a carcinogenic role in ovarian cancer.
Autorzy:
Cui P; Department of Gynecologic Oncology, Harbin Medical University Cancer Hospital, Heilongjiang, 150040, Harbin, China.
Li H; Department of Gynecologic Oncology, Harbin Medical University Cancer Hospital, Heilongjiang, 150040, Harbin, China.
Wang C; Department of Gynecologic Oncology, Harbin Medical University Cancer Hospital, Heilongjiang, 150040, Harbin, China.
Liu Y; Department of Gynecologic Oncology, Harbin Medical University Cancer Hospital, Heilongjiang, 150040, Harbin, China.
Zhang M; Department of Gynecologic Oncology, Harbin Medical University Cancer Hospital, Heilongjiang, 150040, Harbin, China.
Yin Y; Department of Gynecologic Oncology, Harbin Medical University Cancer Hospital, Heilongjiang, 150040, Harbin, China.
Sun Z; Department of Gynecologic Oncology, Harbin Medical University Cancer Hospital, Heilongjiang, 150040, Harbin, China.
Wang Y; Department of Gynecologic Oncology, Harbin Medical University Cancer Hospital, Heilongjiang, 150040, Harbin, China.
Chen X; Department of Gynecologic Oncology, Harbin Medical University Cancer Hospital, Heilongjiang, 150040, Harbin, China. .
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Źródło:
Journal of ovarian research [J Ovarian Res] 2022 Sep 10; Vol. 15 (1), pp. 103. Date of Electronic Publication: 2022 Sep 10.
Typ publikacji:
Journal Article
MeSH Terms:
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/pathology
Proto-Oncogene Proteins c-akt*/metabolism
Animals ; Carcinogenesis/genetics ; Carcinogens ; Carcinoma, Ovarian Epithelial ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition/genetics ; Female ; Humans ; Mice ; Mice, Nude ; Phosphatidylinositol 3-Kinases/metabolism ; Ubiquitin-Conjugating Enzymes/genetics ; Ubiquitin-Conjugating Enzymes/metabolism ; Ubiquitins
Czasopismo naukowe
Tytuł:
Saquayamycin B 1 Suppresses Proliferation, Invasion, and Migration by Inhibiting PI3K/AKT Signaling Pathway in Human Colorectal Cancer Cells.
Autorzy:
Li J; Marine College, Shandong University, Weihai 264209, China.
Han N; Marine College, Shandong University, Weihai 264209, China.
Zhang H; Marine College, Shandong University, Weihai 264209, China.
Xie X; Marine College, Shandong University, Weihai 264209, China.
Zhu Y; Marine College, Shandong University, Weihai 264209, China.
Zhang E; Marine College, Shandong University, Weihai 264209, China.
Ma J; Marine College, Shandong University, Weihai 264209, China.
Shang C; Marine College, Shandong University, Weihai 264209, China.
Yin M; Marine College, Shandong University, Weihai 264209, China.
Xie W; Marine College, Shandong University, Weihai 264209, China.
Li X; Marine College, Shandong University, Weihai 264209, China.; School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
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Źródło:
Marine drugs [Mar Drugs] 2022 Sep 07; Vol. 20 (9). Date of Electronic Publication: 2022 Sep 07.
Typ publikacji:
Journal Article
MeSH Terms:
Colorectal Neoplasms*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Anthraquinones ; Cadherins/genetics ; Cadherins/metabolism ; Cadherins/pharmacology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation/genetics ; Epithelial-Mesenchymal Transition ; Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Messenger ; Signal Transduction
Czasopismo naukowe

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