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Tytuł:
Oxyresveratrol Improves Cognitive Impairments and Episodic-like Memory through Modulating Neuroinflammation and PI3K-Akt Signaling Pathway in LPS-Induced Mice.
Autorzy:
Yin G; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.; Byhealth Co., Ltd., Guangzhou 510030, China.
Pan C; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Liu H; Jihua Laboratory, Foshan 528061, China.
Dong C; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Chang X; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Zhou W; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Wang S; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Du Z; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.; Foshan Allan Conney Biotechnology Co., Ltd., Foshan 523281, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Mar 13; Vol. 29 (6). Date of Electronic Publication: 2024 Mar 13.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Cognitive Dysfunction*/drug therapy
Cognitive Dysfunction*/metabolism
Plant Extracts*
Stilbenes*
Mice ; Animals ; Inflammation/metabolism ; Lipopolysaccharides/adverse effects ; Lipopolysaccharides/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Neuroinflammatory Diseases ; Signal Transduction ; Microglia/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Selectivity Studies and Free Energy Calculations of AKT Inhibitors.
Autorzy:
Zhong HA; Department of Chemistry, University of Nebraska at Omaha, Omaha, NE 68182, USA.
Goodwin DT; Department of Chemistry, University of Nebraska at Omaha, Omaha, NE 68182, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Mar 10; Vol. 29 (6). Date of Electronic Publication: 2024 Mar 10.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Protein Kinase Inhibitors*/pharmacology
Protein Kinase Inhibitors*/chemistry
Angiogenesis Inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PI3K/Akt/mTOR Signaling Pathway as a Target for Colorectal Cancer Treatment.
Autorzy:
Leiphrakpam PD; Graduate Medical Education, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Division of Surgical Oncology, Department of Surgery, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Are C; Graduate Medical Education, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Division of Surgical Oncology, Department of Surgery, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 09; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 09.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/metabolism
Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoinositide-3 Kinase Inhibitors ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pregnancy-Specific Beta-1-Glycoprotein 1 Increases HTR-8/SVneo Cell Migration through the Orai1/Akt Signaling Pathway.
Autorzy:
Wang Q; Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China.; Department of Obstetrics and Gynaecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China.; The Fifth Clinical College of Anhui Medical University, Hefei 230032, China.
Fang Y; Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China.; The Fifth Clinical College of Anhui Medical University, Hefei 230032, China.
Li Y; Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China.; The Fifth Clinical College of Anhui Medical University, Hefei 230032, China.
Liu H; Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China.; The Fifth Clinical College of Anhui Medical University, Hefei 230032, China.
Zhu M; Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China.; The Fifth Clinical College of Anhui Medical University, Hefei 230032, China.
Hu X; Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China.; The Fifth Clinical College of Anhui Medical University, Hefei 230032, China.
Zhou J; Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China.; The Fifth Clinical College of Anhui Medical University, Hefei 230032, China.
Deng A; School of Basic Medical Science, Anhui Medical University, Hefei 230032, China.
Shen B; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China.
Chen H; Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China.; The Fifth Clinical College of Anhui Medical University, Hefei 230032, China.
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Źródło:
Biomolecules [Biomolecules] 2024 Feb 29; Vol. 14 (3). Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Pre-Eclampsia*/metabolism
Phosphatidylethanolamines*
Eosine Yellowish-(YS)/*analogs & derivatives
Female ; Pregnancy ; Humans ; Signal Transduction/physiology ; Transcription Factors ; Cell Movement/physiology ; Glycoproteins ; Cell Proliferation/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dihydromyrcenol Modulates Involucrin Expression through the Akt Signaling Pathway.
Autorzy:
Yang S; Department of Food and Nutrition, BK21 FOUR, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
Kang W; Department of Food and Nutrition, BK21 FOUR, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
Choi D; Department of Food and Nutrition, BK21 FOUR, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
Roh J; Department of Food and Nutrition, BK21 FOUR, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
Park T; Department of Food and Nutrition, BK21 FOUR, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 13; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 13.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Keratinocytes*/metabolism
Octanols*
Protein Precursors*
Monoterpenes*
Humans ; Cell Differentiation/genetics ; Signal Transduction ; RNA, Messenger/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines.
Autorzy:
Tian LY; Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.; Beijing Key Surgical Basic Research Laboratory of Liver Cirrhosis and Liver Cancer, Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing 100044, China.
Smit DJ; Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
Popova NV; Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
Horn S; Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Velasquez LN; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Huber S; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Jücker M; Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 11; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 11.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/metabolism
Liver Neoplasms*/genetics
Liver Neoplasms*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Humans ; Cell Line, Tumor ; Lactic Acid/metabolism ; Oxidoreductases ; Oxygen/metabolism ; Phosphatidylinositol 3-Kinases ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Pyruvates
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Age-Dependent Activation of Purinergic Transmission Contributes to the Development of Epileptogenesis in ADSHE Model Rats.
Autorzy:
Fukuyama K; Department of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.
Motomura E; Department of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.
Okada M; Department of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.
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Źródło:
Biomolecules [Biomolecules] 2024 Feb 08; Vol. 14 (2). Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:
Journal Article
MeSH Terms:
Connexin 43*/genetics
Connexin 43*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Rats ; Animals ; Astrocytes/metabolism ; Seizures/metabolism ; Adenosine Triphosphate/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer.
Autorzy:
Morgos DT; Discipline of Anatomy, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Stefani C; Department I of Family Medicine and Clinical Base, 'Dr. Carol Davila' Central Military Emergency University Hospital, 010825 Bucharest, Romania.
Miricescu D; Discipline of Biochemistry, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Greabu M; Discipline of Biochemistry, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Stanciu S; Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, Central Military Emergency University Hospital, 010825 Bucharest, Romania.
Nica S; Emergency Discipline, University Hospital of Bucharest, 050098 Bucharest, Romania.
Stanescu-Spinu II; Discipline of Physiology, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Balan DG; Discipline of Physiology, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Balcangiu-Stroescu AE; Discipline of Physiology, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Coculescu EC; Discipline of Oral Pathology, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Georgescu DE; Department of General Surgery, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 50474 Bucharest, Romania.; Department of General Surgery, 'Dr. Ion Cantacuzino' Clinical Hospital, 020475 Bucharest, Romania.
Nica RI; Central Military Emergency University Hospital 'Dr. Carol Davila', 010825 Bucharest, Romania.; Discipline of General Surgery, Faculty of Midwifery and Nursing, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 03; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 03.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Stomach Neoplasms*/etiology
Stomach Neoplasms*/genetics
Humans ; Phosphatidylinositol 3-Kinase/metabolism ; Sirolimus ; Phosphatidylinositol 3-Kinases/metabolism ; TOR Serine-Threonine Kinases/metabolism ; MAP Kinase Signaling System
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Potential of PIP3 in Enhancing Wound Healing.
Autorzy:
Blitsman Y; Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Hollander E; Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Benafsha C; Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Yegodayev KM; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Hadad U; The Ilse Katz Institute for Nanoscale Science and Technology, Marcus Campus, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Goldbart R; Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Traitel T; Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Rudich A; Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Elkabets M; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Kost J; Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 01; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Wound Healing*/physiology
Mice ; Animals ; Signal Transduction/physiology ; Fibroblasts/metabolism ; Starch/metabolism ; Cell Proliferation/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sophoridine Counteracts Obesity via Src-Mediated Inhibition of VEGFR Expression and PI3K/AKT Phosphorylation.
Autorzy:
Sun J; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition & Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Wang X; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition & Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
He Y; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition & Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Tian X; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition & Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Yuan T; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition & Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Yang G; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition & Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Yu T; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition & Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 19; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Matrines*
Mice ; Animals ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Vascular Endothelial Growth Factor A/metabolism ; Adipocytes/metabolism ; Mice, Inbred C57BL ; Obesity/drug therapy ; Obesity/metabolism ; Diet, High-Fat/adverse effects ; 3T3-L1 Cells ; Adipogenesis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Let-7a-5p Regulates Animal Lipid Accumulation by Targeting Srebf2 and Thbs1 Signaling.
Autorzy:
Shao J; College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Jiang G; College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Li Y; College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Wang M; College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Tang T; College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Wang J; College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Jia X; College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Lai S; College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 11; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Phosphatidylinositol 3-Kinases*
Proto-Oncogene Proteins c-akt*
Lipid Metabolism*
Animals ; Obesity ; TOR Serine-Threonine Kinases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch.
Autorzy:
Bracho-Valdés I; Department of Pharmacology, Cinvestav-IPN. Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Mexico City 07360, Mexico.; Academic Department of Apparatus and Systems I, Deanship of Health Sciences, Universidad Autónoma de Guadalajara, Av. Patria 1201, Zapopan 45129, Mexico.
Cervantes-Villagrana RD; Department of Pharmacology, Cinvestav-IPN. Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Mexico City 07360, Mexico.; Department of Pharmacology, Moores Cancer Center, School of Medicine, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Beltrán-Navarro YM; Department of Pharmacology, Cinvestav-IPN. Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Mexico City 07360, Mexico.
Olguín-Olguín A; Department of Pharmacology, Cinvestav-IPN. Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Mexico City 07360, Mexico.
Escobar-Islas E; Department of Pharmacology, Cinvestav-IPN. Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Mexico City 07360, Mexico.
Carretero-Ortega J; Department of Pharmacology, Cinvestav-IPN. Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Mexico City 07360, Mexico.
Olivares-Reyes JA; Department of Biochemistry, Cinvestav-IPN. Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Mexico City 07360, Mexico.
Reyes-Cruz G; Department of Cell Biology, Cinvestav-IPN. Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Mexico City 07360, Mexico.
Gutkind JS; Department of Pharmacology, Moores Cancer Center, School of Medicine, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Vázquez-Prado J; Department of Pharmacology, Cinvestav-IPN. Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Mexico City 07360, Mexico.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 15; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 15.
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Chaperones*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
HSP70 Heat-Shock Proteins/metabolism ; Phosphorylation ; Ubiquitination ; HEK293 Cells ; Humans ; Animals ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Metabolites-Based Network Pharmacology to Preliminarily Verify In Vitro Anti-Inflammatory Effect of Ardisiacrispin B.
Autorzy:
Zhou W; School of Basic Medicine, Guizhou Medical University, Guiyang 550004, China.; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550004, China.; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang 550004, China.
Yang G; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550004, China.
Wen Y; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550004, China.
Xiao Q; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550004, China.
Sun L; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550004, China.
Li Y; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Medical University, Guiyang 550004, China.
Gong Z; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang 550004, China.
Wang Y; School of Basic Medicine, Guizhou Medical University, Guiyang 550004, China.; School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550004, China.; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang 550004, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 02; Vol. 24 (23). Date of Electronic Publication: 2023 Dec 02.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Saponins*/chemistry
Rats ; Animals ; Phosphatidylinositol 3-Kinases/metabolism ; Network Pharmacology ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Molecular Docking Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Acute In Vivo Administration of Compound 21 Stimulates Akt and ERK1/2 Phosphorylation in Mouse Heart and Adipose Tissue.
Autorzy:
Quiroga DT; Facultad de Farmacia y Bioquímica, Departamento de Química Biológica and IQUIFIB (UBA-CONICET), Universidad de Buenos Aires, Buenos Aires C1113AAD, Argentina.
Narvaéz Pardo JA; Facultad de Farmacia y Bioquímica, Departamento de Química Biológica and IQUIFIB (UBA-CONICET), Universidad de Buenos Aires, Buenos Aires C1113AAD, Argentina.
Zubiría MG; Laboratorio de Neuroendocrinología, Instituto Multidisciplinario de Biología Celular (IMBICE), CICPBA-CONICET-UNLP), La Plata B1906APO, Argentina.
Barrales B; Facultad de Farmacia y Bioquímica, Departamento de Química Biológica and IQUIFIB (UBA-CONICET), Universidad de Buenos Aires, Buenos Aires C1113AAD, Argentina.
Muñoz MC; Facultad de Farmacia y Bioquímica, Departamento de Química Biológica and IQUIFIB (UBA-CONICET), Universidad de Buenos Aires, Buenos Aires C1113AAD, Argentina.
Giovambattista A; Laboratorio de Neuroendocrinología, Instituto Multidisciplinario de Biología Celular (IMBICE), CICPBA-CONICET-UNLP), La Plata B1906APO, Argentina.
Dominici FP; Facultad de Farmacia y Bioquímica, Departamento de Química Biológica and IQUIFIB (UBA-CONICET), Universidad de Buenos Aires, Buenos Aires C1113AAD, Argentina.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 28; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 28.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*
Insulins*
Mice ; Animals ; Male ; Phosphorylation ; MAP Kinase Signaling System ; Mice, Inbred C57BL ; Adipose Tissue/metabolism ; Receptor, Angiotensin, Type 2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Role of the p38/AKT Pathway in the Promotion of Cell Proliferation by Serum Heat Inactivation.
Autorzy:
Geng H; College of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China.
Li R; College of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China.
Feng D; College of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China.
Zhu Y; College of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China.
Deng L; College of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 20; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 20.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*
Hot Temperature*
Reactive Oxygen Species ; Cell Proliferation ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effects of GHRH Deficiency and GHRH Antagonism on Emotional Disorders in Mice.
Autorzy:
Recinella L; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, 66013 Chieti, Italy.
Libero ML; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, 66013 Chieti, Italy.; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14014 Cordoba, Spain.
Veschi S; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, 66013 Chieti, Italy.
Piro A; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, 66013 Chieti, Italy.
Marconi GD; Department of Innovative Technologies in Medicine & Dentistry, 'G. d'Annunzio' University of Chieti-Pescara, 66013 Chieti, Italy.
Diomede F; Department of Innovative Technologies in Medicine & Dentistry, 'G. d'Annunzio' University of Chieti-Pescara, 66013 Chieti, Italy.
Chiavaroli A; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, 66013 Chieti, Italy.
Orlando G; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, 66013 Chieti, Italy.
Ferrante C; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, 66013 Chieti, Italy.
Florio R; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, 66013 Chieti, Italy.
Lamolinara A; Department of Neuroscience Imaging and Clinical Sciences, 'G. d'Annunzio' University of Chieti-Pescara, 66013 Chieti, Italy.
Cai R; Veterans Affairs Medical Center, Miami, FL 33125, USA.; Division of Medical/Oncology and Endocrinology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.
Sha W; Veterans Affairs Medical Center, Miami, FL 33125, USA.; Division of Medical/Oncology and Endocrinology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.
Schally AV; Veterans Affairs Medical Center, Miami, FL 33125, USA.; Division of Medical/Oncology and Endocrinology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.
Salvatori R; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Brunetti L; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, 66013 Chieti, Italy.
Leone S; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, 66013 Chieti, Italy.
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Źródło:
Cells [Cells] 2023 Nov 12; Vol. 12 (22). Date of Electronic Publication: 2023 Nov 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
NF-kappa B*
Proto-Oncogene Proteins c-akt*
Animals ; Mice ; Growth Hormone-Releasing Hormone/genetics ; Growth Hormone-Releasing Hormone/metabolism ; Homozygote
Czasopismo naukowe
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Tytuł:
Browning of Mammary Fat Suppresses Pubertal Mammary Gland Development of Mice via Elevation of Serum Phosphatidylcholine and Inhibition of PI3K/Akt Pathway.
Autorzy:
Lang L; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Zheng J; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Liang S; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Zhang F; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Fu Y; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Deng K; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Li F; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Yang X; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Wang J; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Luo Y; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Zhang S; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Zhu X; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Wang L; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Gao P; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Zhu C; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Shu G; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Xi Q; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Zhang Y; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Jiang Q; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Wang S; Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 10; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 10.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Phosphatidylinositol 3-Kinases*/metabolism
Animals ; Mice ; Signal Transduction ; Adipocytes, Brown/metabolism ; Lecithins/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
L-Type Amino Acid Transporter 1 (LAT1) Promotes PMA-Induced Cell Migration through mTORC2 Activation at the Lysosome.
Autorzy:
Tae K; Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Kim SJ; Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Cho SW; Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Lee H; Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Cha HS; Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Choi CY; Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
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Źródło:
Cells [Cells] 2023 Oct 23; Vol. 12 (20). Date of Electronic Publication: 2023 Oct 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lysosomes*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Large Neutral Amino Acid-Transporter 1*/metabolism
Cell Movement/physiology ; Mechanistic Target of Rapamycin Complex 1 ; Mechanistic Target of Rapamycin Complex 2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
AKT Mediates Adiponectin-Dependent Regulation of VSMC Phenotype.
Autorzy:
Cullen AE; Department of Nutrition and Integrative Physiology, Florida State University, Tallahassee, FL 32306, USA.; Department of Human Physiology, University of Oregon, Eugene, OR 97403, USA.
Centner AM; Department of Nutrition and Integrative Physiology, Florida State University, Tallahassee, FL 32306, USA.
Deitado R; Department of Nutrition and Integrative Physiology, Florida State University, Tallahassee, FL 32306, USA.
Ismaeel A; Department of Physiology, University of Kentucky, Lexington, KY 40536, USA.
Koutakis P; Department of Biology, Baylor University, Waco, TX 76706, USA.
Muller-Delp J; Department of Biological Sciences, Florida State University, Tallahassee, FL 32306, USA.
Salazar G; Department of Nutrition and Integrative Physiology, Florida State University, Tallahassee, FL 32306, USA.; Center for Advancing Exercise and Nutrition Research on Aging (CAENRA), Florida State University, Tallahassee, FL 32306, USA.
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Źródło:
Cells [Cells] 2023 Oct 20; Vol. 12 (20). Date of Electronic Publication: 2023 Oct 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Adiponectin*/genetics
Adiponectin*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Male ; Mice ; Female ; Animals ; Muscle, Smooth, Vascular/metabolism ; Phenotype ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Thrombin-Induced COX-2 Expression and PGE 2 Synthesis in Human Tracheal Smooth Muscle Cells: Role of PKCδ/Pyk2-Dependent AP-1 Pathway Modulation.
Autorzy:
Yang CC; Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital at Taoyuan, Taoyuan 333008, Taiwan.; School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan.
Lee IT; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110301, Taiwan.
Lin YJ; Ph.D. Program for Biotech Pharmaceutical Industry, China Medical University, Taichung 406040, Taiwan.
Wu WB; School of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan.; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
Hsiao LD; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
Yang CM; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 13; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 13.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Transcription Factor AP-1*/metabolism
Humans ; CSK Tyrosine-Protein Kinase/metabolism ; Cyclooxygenase 2/metabolism ; Dinoprostone/metabolism ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Focal Adhesion Kinase 2/genetics ; Focal Adhesion Kinase 2/metabolism ; Inflammation/metabolism ; Myocytes, Smooth Muscle/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Resveratrol/pharmacology ; Resveratrol/metabolism ; src-Family Kinases/metabolism ; Thrombin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 1465

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