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Wyszukujesz frazę ""Proto-Oncogene Proteins c-bcl-2"" wg kryterium: Temat


Tytuł :
Interaction between Ras and Bcl2L12 in B cells suppresses IL-10 expression.
Autorzy :
Li J; Department of Otolaryngology, Jinjiang Municipal Hospital, Jinjiang, China.
Yang G; Department of Otolaryngology, Jinjiang Municipal Hospital, Jinjiang, China; Department of Otolaryngology, Longgang Central Hospital, Shenzhen, China.
Luo XQ; Department of Pediatric Otolaryngology, Shenzhen Hospital, Southern Medical University, Shenzhen, China. Electronic address: .
Mo LH; Department of Pediatric Otolaryngology, Shenzhen Hospital, Southern Medical University, Shenzhen, China; Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Shenzhen, China; Research Center of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Qiu SY; Department of Pediatric Otolaryngology, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
Yang LT; Department of Clinical Chemistry, Longgang District People's Hospital, Shenzhen, China.
Liu DB; Department of Pediatric Otolaryngology, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
An YF; Department of Otolaryngology, Head & Neck Surgery, Second Hospital of Shanxi Medical University, Taiyuan, China. Electronic address: .
Yang PC; Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Shenzhen, China; Research Center of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China. Electronic address: .
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Źródło :
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2021 Aug; Vol. 229, pp. 108775. Date of Electronic Publication: 2021 Jun 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*immunology
B-Lymphocytes/*metabolism
Interleukin-10/*metabolism
Muscle Proteins/*metabolism
Proto-Oncogene Proteins c-bcl-2/*metabolism
ras Proteins/*metabolism
Adolescent ; Adult ; B-Lymphocytes/pathology ; Child ; Down-Regulation ; Female ; GTPase-Activating Proteins/metabolism ; Gene Knockdown Techniques ; Humans ; Immune Tolerance ; Interleukin-10/genetics ; Male ; Muscle Proteins/antagonists & inhibitors ; Muscle Proteins/genetics ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Proto-Oncogene Proteins c-bcl-2/genetics ; Recurrence ; Rho Guanine Nucleotide Exchange Factors/genetics ; Rho Guanine Nucleotide Exchange Factors/metabolism ; Signal Transduction ; Sp1 Transcription Factor/antagonists & inhibitors ; Sp1 Transcription Factor/genetics ; Sp1 Transcription Factor/metabolism ; Tonsillitis/immunology ; Tonsillitis/metabolism ; Tonsillitis/pathology ; Up-Regulation ; Young Adult
Czasopismo naukowe
Tytuł :
High-grade B-cell lymphomas with MYC and BCL2 translocations lack tumor-associated macrophages and PD-L1 expression: A possible noninflamed subgroup.
Autorzy :
Breinholt MF; Department of Patologi, Herlev og Gentofte Hospital, Herlev, Denmark.
Oliveira DVNP; Department of Patologi, Herlev og Gentofte Hospital, Herlev, Denmark.
Klausen TW; Department of Hematology, Herlev og Gentofte Hospital, Herlev, Denmark.
Gang AO; Department of Hematology, Herlev og Gentofte Hospital, Herlev, Denmark.
Schejbel L; Department of Patologi, Herlev og Gentofte Hospital, Herlev, Denmark.
Pedersen MØ; Department of Patologi, Herlev og Gentofte Hospital, Herlev, Denmark.
Elbaek MV
Clasen-Linde E; Department of Patologi, Rigshospitalet, Copenhagen, Denmark.
Nielsen SL; Department of Patologi, Herlev og Gentofte Hospital, Herlev, Denmark.
Knudsen H; Department of Patologi, Herlev og Gentofte Hospital, Herlev, Denmark.
Høgdall E; Department of Patologi, Herlev og Gentofte Hospital, Herlev, Denmark.
Nørgaard P; Department of Patologi, Herlev og Gentofte Hospital, Herlev, Denmark.
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Źródło :
Hematological oncology [Hematol Oncol] 2021 Aug; Vol. 39 (3), pp. 284-292. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
B-Lymphocytes*/metabolism
B-Lymphocytes*/pathology
B7-H1 Antigen*/biosynthesis
B7-H1 Antigen*/genetics
Gene Expression Regulation, Leukemic*
Lymphoma, Large B-Cell, Diffuse*/genetics
Lymphoma, Large B-Cell, Diffuse*/metabolism
Lymphoma, Large B-Cell, Diffuse*/pathology
Proto-Oncogene Proteins c-bcl-2*/genetics
Proto-Oncogene Proteins c-bcl-2*/metabolism
Proto-Oncogene Proteins c-myc*/genetics
Proto-Oncogene Proteins c-myc*/metabolism
Translocation, Genetic*
Aged ; Aged, 80 and over ; Female ; Humans ; Inflammation/genetics ; Inflammation/metabolism ; Inflammation/pathology ; Male ; Middle Aged ; Tumor-Associated Macrophages/metabolism ; Tumor-Associated Macrophages/pathology
Czasopismo naukowe
Tytuł :
Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm.
Autorzy :
Roychowdhury T; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Lu H; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Hornsby WE; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Crone B; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Wang GT; Center for Statistical Genetics, Gertrude H. Sergievsky Center, and the Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.
Guo DC; Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 70030, USA.
Sendamarai AK; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA 02130, USA; Booz Allen Hamilton, McLean, VA 22102, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Devineni P; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA 02130, USA.
Lin M; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA 02114, USA.
Zhou W; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Graham SE; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Wolford BN; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Surakka I; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Wang Z; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Chang L; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Zhang J; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Mathis M; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA; Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109, USA.
Brummett CM; Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109, USA.
Melendez TL; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Shea MJ; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Kim KM; Department of Cardiac Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Deeb GM; Department of Cardiac Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Patel HJ; Department of Cardiac Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Eliason J; Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Eagle KA; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Yang B; Department of Cardiac Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Ganesh SK; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Brumpton B; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim 7030, Norway; HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger 7600, Norway.
Åsvold BO; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway; HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger 7600, Norway; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim 7030, Norway.
Skogholt AH; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway.
Hveem K; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway; HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger 7600, Norway.
Pyarajan S; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA 02130, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Klarin D; Malcolm Randall VA Medical Center, Gainesville, FL 32608, USA; Division of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville, FL 32608, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Tsao PS; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305-5406, USA.
Damrauer SM; Department of Surgery, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Leal SM; Center for Statistical Genetics, Gertrude H. Sergievsky Center, and the Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA; Taub Institute for Alzheimer disease and the Aging Brain, Columbia University, NY 10032, USA.
Milewicz DM; Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 70030, USA.
Chen YE; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cardiac Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Garcia-Barrio MT; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: .
Willer CJ; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: .
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Corporate Authors :
VA Million Veteran Program
Źródło :
American journal of human genetics [Am J Hum Genet] 2021 Sep 02; Vol. 108 (9), pp. 1578-1589. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Quantitative Trait Loci*
Aortic Aneurysm, Thoracic/*genetics
Diabetes Mellitus, Type 2/*genetics
Endothelial Cells/*metabolism
Proto-Oncogene Proteins c-bcl-2/*genetics
Transcription Factor 7-Like 2 Protein/*genetics
Aorta/metabolism ; Aorta/pathology ; Aortic Aneurysm, Thoracic/metabolism ; Aortic Aneurysm, Thoracic/pathology ; Case-Control Studies ; Caspase 3/genetics ; Caspase 3/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/pathology ; Endothelial Cells/pathology ; Gene Expression Regulation ; Genome, Human ; Genome-Wide Association Study ; Humans ; Introns ; Michigan ; Muscle, Smooth, Vascular/metabolism ; Muscle, Smooth, Vascular/pathology ; Mutation ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Transcription Factor 7-Like 2 Protein/metabolism ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Serum B cell lymphoma-2 concentrations and mortality of patients with spontaneous intracerebral hemorrhage.
Autorzy :
Lorente L; Intensive Care Unit, Hospital Universitario de Canarias, Ofra s/n, La Laguna, 38320, Santa Cruz de Tenerife, Spain. .
Martín MM; Intensive Care Unit, Hospital Universitario Nuestra Señora de Candelaria, Crta del Rosario s/n, 38010, Santa Cruz de Tenerife, Spain.
González-Rivero AF; Laboratory Department, Hospital Universitario de Canarias, Ofra, s/n, La Laguna, 38320, Santa Cruz de Tenerife, Spain.
Pérez-Cejas A; Laboratory Department, Hospital Universitario de Canarias, Ofra, s/n, La Laguna, 38320, Santa Cruz de Tenerife, Spain.
Ramos-Gómez L; Intensive Care Unit, Hospital General La Palma, Buenavista de Arriba s/n, La Palma, 38713, Breña Alta, Spain.
Cáceres JJ; Intensive Care Unit, Hospital Insular, Plaza Dr. Pasteur s/n, 35016, Las Palmas de Gran Canaria, Spain.
Solé-Violán J; Intensive Care Unit, Hospital Universitario Dr. Negrín, CIBERES, Barranco de la Ballena s/n, 35010, Las Palmas de Gran Canaria, Spain.
Villacampa-Jiménez JJ; Laboratory Department, Hospital Universitario de Canarias, Ofra, s/n, La Laguna, 38320, Santa Cruz de Tenerife, Spain.
Jiménez A; Research Unit, Hospital Universitario de Canarias, Ofra s/n, La Laguna, 38320, Santa Cruz de Tenerife, Spain.
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Źródło :
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2021 Sep; Vol. 42 (9), pp. 3631-3636. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Cerebral Hemorrhage*
Proto-Oncogene Proteins c-bcl-2*
Biomarkers ; Glasgow Coma Scale ; Humans ; Prospective Studies
Czasopismo naukowe
Tytuł :
Bok joining the "Ca club".
Autorzy :
de Ridder I; KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, and Leuven Kanker Instituut, Campus Gasthuisberg O/N-1 Bus 802, Herestraat 49, 3000 Leuven, Belgium.
Rosa N; KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, and Leuven Kanker Instituut, Campus Gasthuisberg O/N-1 Bus 802, Herestraat 49, 3000 Leuven, Belgium.
Kerkhofs M; KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, and Leuven Kanker Instituut, Campus Gasthuisberg O/N-1 Bus 802, Herestraat 49, 3000 Leuven, Belgium.
Bultynck G; KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, and Leuven Kanker Instituut, Campus Gasthuisberg O/N-1 Bus 802, Herestraat 49, 3000 Leuven, Belgium. Electronic address: .
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Źródło :
Cell calcium [Cell Calcium] 2021 Sep; Vol. 98, pp. 102438. Date of Electronic Publication: 2021 Jul 02.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Apoptosis*
Proto-Oncogene Proteins c-bcl-2*
Czasopismo naukowe
Tytuł :
Multiple myeloma with t(11;14)-associated immature phenotype has lower CD38 expression and higher BCL2 dependence.
Autorzy :
Kitadate A; Division of Hematology/Oncology, Department of Medicine, Kameda Medical Center, Kamogawa, Japan.; Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.
Terao T; Division of Hematology/Oncology, Department of Medicine, Kameda Medical Center, Kamogawa, Japan.
Narita K; Division of Hematology/Oncology, Department of Medicine, Kameda Medical Center, Kamogawa, Japan.
Ikeda S; Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.
Takahashi Y; Department of Life Science, Akita University Graduate School of Engineering Science, Akita, Japan.
Tsushima T; Division of Hematology/Oncology, Department of Medicine, Kameda Medical Center, Kamogawa, Japan.
Miura D; Division of Hematology/Oncology, Department of Medicine, Kameda Medical Center, Kamogawa, Japan.
Takeuchi M; Division of Hematology/Oncology, Department of Medicine, Kameda Medical Center, Kamogawa, Japan.
Takahashi N; Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.
Matsue K; Division of Hematology/Oncology, Department of Medicine, Kameda Medical Center, Kamogawa, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Sep; Vol. 112 (9), pp. 3645-3654. Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article
MeSH Terms :
Phenotype*
ADP-ribosyl Cyclase 1/*metabolism
Membrane Glycoproteins/*metabolism
Multiple Myeloma/*genetics
Multiple Myeloma/*metabolism
Proto-Oncogene Proteins c-bcl-2/*metabolism
Translocation, Genetic/*genetics
ADP-ribosyl Cyclase 1/antagonists & inhibitors ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; B-Lymphocytes/metabolism ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Chromosomes, Human, Pair 11/genetics ; Chromosomes, Human, Pair 14/genetics ; Female ; Humans ; Male ; Membrane Glycoproteins/antagonists & inhibitors ; Middle Aged ; Multiple Myeloma/drug therapy ; Multiple Myeloma/pathology ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Signal Transduction/drug effects ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use ; Tretinoin/pharmacology
Czasopismo naukowe
Tytuł :
Inhibitors of BCL2A1/Bfl-1 protein: Potential stock in cancer therapy.
Autorzy :
Li X; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Dou J; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
You Q; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Jiang Z; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Aug 05; Vol. 220, pp. 113539. Date of Electronic Publication: 2021 May 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*pharmacology
Bridged Bicyclo Compounds, Heterocyclic/*pharmacology
Leukemia, Lymphocytic, Chronic, B-Cell/*drug therapy
Proto-Oncogene Proteins c-bcl-2/*antagonists & inhibitors
Sulfonamides/*pharmacology
Antineoplastic Agents/chemistry ; Bridged Bicyclo Compounds, Heterocyclic/chemistry ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism ; Minor Histocompatibility Antigens/metabolism ; Models, Molecular ; Molecular Structure ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Sulfonamides/chemistry
Czasopismo naukowe
Tytuł :
Targeting Bcl-2 for cancer therapy.
Autorzy :
Zhang L; Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, LN, China.
Lu Z; Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, LN, China. Electronic address: .
Zhao X; Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, LN, China. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2021 Aug; Vol. 1876 (1), pp. 188569. Date of Electronic Publication: 2021 May 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Apoptosis/*drug effects
Neoplasms/*drug therapy
Proto-Oncogene Proteins c-bcl-2/*antagonists & inhibitors
Animals ; Drug Resistance, Neoplasm ; Humans ; Molecular Targeted Therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
High Bax/Bcl-2 ratio is associated with good prognosis and better survival in patients with B cell chronic lymphocytic leukemia.
Autorzy :
Helaly NA; Department of Medical Laboratory Technology, Faculty of Applied Health Sciences, Pharos University, Alexandria, Egypt.
Esheba NE; Department of Internal Medicine, Hematology Unit, Faculty of Medicine, Tanta University, Egypt. Electronic address: .
Ammo DEA; Department of Clinical Pathology, Faculty of Medicine, Tanta University, Egypt.
Elwan NM; Department of Clinical Pathology, Faculty of Medicine, Tanta University, Egypt.
Elkholy RA; Department of Clinical Pathology, Faculty of Medicine, Tanta University, Egypt.
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Źródło :
Leukemia research [Leuk Res] 2021 Aug; Vol. 107, pp. 106604. Date of Electronic Publication: 2021 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor*
Leukemia, Lymphocytic, Chronic, B-Cell/*metabolism
Leukemia, Lymphocytic, Chronic, B-Cell/*mortality
Proto-Oncogene Proteins c-bcl-2/*metabolism
bcl-2-Associated X Protein/*metabolism
Humans ; Immunophenotyping ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/etiology ; Neoplasm Staging ; Prognosis ; Proto-Oncogene Proteins c-bcl-2/genetics ; ROC Curve ; bcl-2-Associated X Protein/genetics
Czasopismo naukowe
Tytuł :
Predicting ROR1/BCL2 combination targeted therapy of small cell carcinoma of the lung.
Autorzy :
Wang WZ; Department of Internal Medicine, Division of Medical Oncology, The Ohio State University, Columbus, OH, 43210, USA. .; The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA. .
Shilo K; Department of Pathology, The Ohio State University, Columbus, OH, 43210, USA.
Amann JM; Department of Internal Medicine, Division of Medical Oncology, The Ohio State University, Columbus, OH, 43210, USA.; The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
Shulman A; Department of Internal Medicine, Division of Medical Oncology, The Ohio State University, Columbus, OH, 43210, USA.; The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
Hojjat-Farsangi M; Department of Oncology-Pathology, Karolinska Institutet, 17177, Stockholm, Sweden.
Mellstedt H; Department of Oncology-Pathology, Karolinska Institutet, 17177, Stockholm, Sweden.
Schultz J; Kancera AB, Banvaktsvägen 22, 17148, Solna, Sweden.
Croce CM; The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, 43210, USA.
Carbone DP; Department of Internal Medicine, Division of Medical Oncology, The Ohio State University, Columbus, OH, 43210, USA. .; The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA. .
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Źródło :
Cell death & disease [Cell Death Dis] 2021 Jun 04; Vol. 12 (6), pp. 577. Date of Electronic Publication: 2021 Jun 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Bridged Bicyclo Compounds, Heterocyclic/*pharmacology
Lung Neoplasms/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins c-bcl-2/*antagonists & inhibitors
Receptor Tyrosine Kinase-like Orphan Receptors/*antagonists & inhibitors
Small Cell Lung Carcinoma/*drug therapy
Sulfonamides/*pharmacology
Bridged Bicyclo Compounds, Heterocyclic/administration & dosage ; Cell Line, Tumor ; Drug Synergism ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Molecular Targeted Therapy ; Protein Kinase Inhibitors/administration & dosage ; Proto-Oncogene Proteins c-bcl-2/biosynthesis ; Proto-Oncogene Proteins c-bcl-2/genetics ; Receptor Tyrosine Kinase-like Orphan Receptors/biosynthesis ; Receptor Tyrosine Kinase-like Orphan Receptors/genetics ; Small Cell Lung Carcinoma/genetics ; Small Cell Lung Carcinoma/metabolism ; Sulfonamides/administration & dosage ; Survival Analysis
Czasopismo naukowe
Tytuł :
Susceptibility of multiple myeloma to B-cell lymphoma 2 family inhibitors.
Autorzy :
Lernoux M; Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg 9, rue Edward Steichen, L-2540 Luxembourg, Luxembourg.
Schnekenburger M; Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg 9, rue Edward Steichen, L-2540 Luxembourg, Luxembourg.
Dicato M; Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg 9, rue Edward Steichen, L-2540 Luxembourg, Luxembourg.
Diederich M; College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Jun; Vol. 188, pp. 114526. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Resistance, Neoplasm/*drug effects
Lymphoma, B-Cell/*drug therapy
Multiple Myeloma/*drug therapy
Proto-Oncogene Proteins c-bcl-2/*antagonists & inhibitors
Tumor Microenvironment/*drug effects
Animals ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Drug Resistance, Neoplasm/physiology ; Humans ; Immunotherapy/methods ; Lymphoma, B-Cell/immunology ; Lymphoma, B-Cell/metabolism ; Multiple Myeloma/immunology ; Multiple Myeloma/metabolism ; Proto-Oncogene Proteins c-bcl-2/immunology ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Tumor Microenvironment/physiology
Czasopismo naukowe
Tytuł :
Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X L and BCL-2.
Autorzy :
Roy MJ; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.
Vom A; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.
Okamoto T; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.
Smith BJ; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.
Birkinshaw RW; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.
Yang H; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.
Abdo H; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.
White CA; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.
Segal D; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
Huang DCS; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.
Baell JB; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.
Colman PM; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.
Czabotar PE; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.
Lessene G; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.; Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, VIC 3050, Australia.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 5447-5469. Date of Electronic Publication: 2021 Apr 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemistry
Proto-Oncogene Proteins c-bcl-2/*antagonists & inhibitors
Urea/*analogs & derivatives
bcl-X Protein/*antagonists & inhibitors
Animals ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Binding Sites ; Biphenyl Compounds/chemistry ; Biphenyl Compounds/metabolism ; Cell Line ; Cell Survival/drug effects ; Crystallography, X-Ray ; Humans ; Hydrophobic and Hydrophilic Interactions ; Inhibitory Concentration 50 ; Mice ; Molecular Dynamics Simulation ; Nitrophenols/chemistry ; Nitrophenols/metabolism ; Piperazines/chemistry ; Piperazines/metabolism ; Protein Binding ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Structure-Activity Relationship ; Sulfonamides/chemistry ; Sulfonamides/metabolism ; Surface Plasmon Resonance ; Urea/metabolism ; Urea/pharmacology ; bcl-X Protein/genetics ; bcl-X Protein/metabolism
Czasopismo naukowe
Tytuł :
Cell of origin (COO), BCL2/MYC status and IPI define a group of patients with Diffuse Large B-cell Lymphoma (DLBCL) with poor prognosis in a real-world clinical setting.
Autorzy :
Bettelli S; SSD Patologia Molecolare e Medicina Predittiva, AOU Modena, Dipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell'Adulto, Università di Modena e Reggio Emilia, Italy.
Marcheselli R; Fondazione Italiana Linfomi - Onlus, Modena, Italy.
Pozzi S; Dipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell'Adulto, Università di Modena e Reggio Emilia, Italy.
Marcheselli L; Fondazione Italiana Linfomi - Onlus, Modena, Italy.
Papotti R; International PhD School in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, Modena, Italy.
Forti E; SSD Patologia Molecolare e Medicina Predittiva, AOU Modena, Dipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell'Adulto, Università di Modena e Reggio Emilia, Italy.
Cox MCC; Haematology Department, King's College Hospital NHS Trust and UOC Ematologia, AOU Sant'Andrea, Roma, Italy.
Di Napoli A; Anatomia Patologica, Ospedale Sant'Andrea, Roma, Italy.
Tadmor T; Hematology, Bnai Zion Medical Center, Haifa, Israel.
Mansueto GR; IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture, Italy.
Musto P; Aldo Moro University School of Medicine and Unit of Hematology and Stem Cell Transplantation, AOU Consorziale Policlinico, Bari, Italy.
Flenghi L; Azienda Ospedaliera di Perugia, Department of Emergency and Organ Transplantation, Italy.
Quintini M; Azienda Ospedaliera di Perugia, Department of Emergency and Organ Transplantation, Italy.
Galimberti S; Ematologia, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Lalinga V; Anatomia Patologica, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture, Italy.
Donati V; Anatomia Patologica, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Maiorana A; Dipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell'Adulto, Università di Modena e Reggio Emilia, Italy.
Polliack A; Hadassah- Hebrew University Medical Center Jerusalem, Israel.
Sacchi S; Dipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell'Adulto, Università di Modena e Reggio Emilia, Italy. Electronic address: .
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Źródło :
Leukemia research [Leuk Res] 2021 May; Vol. 104, pp. 106552. Date of Electronic Publication: 2021 Feb 27.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphoma, Large B-Cell, Diffuse*/drug therapy
Lymphoma, Large B-Cell, Diffuse*/genetics
Lymphoma, Large B-Cell, Diffuse*/metabolism
Lymphoma, Large B-Cell, Diffuse*/mortality
Proto-Oncogene Proteins c-bcl-2*/genetics
Proto-Oncogene Proteins c-bcl-2*/metabolism
Proto-Oncogene Proteins c-myc/*administration & dosage
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols ; Cyclophosphamide ; Doxorubicin ; Female ; Humans ; Male ; Middle Aged ; Prednisone ; Proto-Oncogene Proteins c-myc/adverse effects ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Retrospective Studies ; Rituximab ; Vincristine
Raport
Tytuł :
Photobiomodulation by Near-Infrared 980-nm Wavelengths Regulates Pre-Osteoblast Proliferation and Viability through the PI3K/Akt/Bcl-2 Pathway.
Autorzy :
Agas D; School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, 62032 Macerata, Italy.
Hanna R; Department of Oral Surgery, Dental Institute, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK.; Department of Surgical and Diagnostic Sciences, University of Genoa, 16132 Genoa, Italy.
Benedicenti S; Department of Surgical and Diagnostic Sciences, University of Genoa, 16132 Genoa, Italy.
De Angelis N; Department of Surgical and Diagnostic Sciences, University of Genoa, 16132 Genoa, Italy.
Sabbieti MG; School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, 62032 Macerata, Italy.
Amaroli A; Department of Surgical and Diagnostic Sciences, University of Genoa, 16132 Genoa, Italy.; Department of Orthopaedic Dentistry, First Moscow State Medical University (Sechenov University), 11991 Moscow, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 15; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 15.
Typ publikacji :
Journal Article
MeSH Terms :
Osteoblasts/*cytology
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Proto-Oncogene Proteins c-bcl-2/*metabolism
Skull/*cytology
Animals ; Cell Differentiation/radiation effects ; Cell Proliferation/radiation effects ; Cell Survival/radiation effects ; Lasers ; Low-Level Light Therapy/methods ; Mice ; Osteoblasts/metabolism ; Osteoblasts/radiation effects ; Osteogenesis ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-bcl-2/genetics ; Signal Transduction ; Skull/metabolism ; Skull/radiation effects
Czasopismo naukowe
Tytuł :
Bcl-2/Bcl-xL inhibitor ABT-263 overcomes hypoxia-driven radioresistence and improves radiotherapy.
Autorzy :
Ritter V; Institute for Cell Biology (Cancer Research), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Krautter F; Institute for Cell Biology (Cancer Research), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Klein D; Institute for Cell Biology (Cancer Research), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Jendrossek V; Institute for Cell Biology (Cancer Research), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Rudner J; Institute for Cell Biology (Cancer Research), University Hospital Essen, University of Duisburg-Essen, Essen, Germany. .
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Źródło :
Cell death & disease [Cell Death Dis] 2021 Jul 13; Vol. 12 (7), pp. 694. Date of Electronic Publication: 2021 Jul 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*/drug effects
Apoptosis*/radiation effects
Radiation Tolerance*
Aniline Compounds/*pharmacology
Colonic Neoplasms/*radiotherapy
Lung Neoplasms/*drug therapy
Proto-Oncogene Proteins c-bcl-2/*antagonists & inhibitors
Radiation-Sensitizing Agents/*pharmacology
Sulfonamides/*pharmacology
bcl-X Protein/*antagonists & inhibitors
Animals ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; HCT116 Cells ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Macrolides/metabolism ; Mice, Nude ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Signal Transduction ; Tumor Burden/drug effects ; Tumor Burden/radiation effects ; Tumor Hypoxia ; Tumor Microenvironment ; Xenograft Model Antitumor Assays ; bcl-X Protein/metabolism
Czasopismo naukowe
Tytuł :
Venetoclax nanomedicine alleviates acute lung injury via increasing neutrophil apoptosis.
Autorzy :
Su R; Center for Nanomedicine, Department of Pediatrics and Department of Allergy, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China. .
Wang H; Center for Nanomedicine, Department of Pediatrics and Department of Allergy, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China. .
Xiao C; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Tao Y; Center for Nanomedicine, Department of Pediatrics and Department of Allergy, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China. and Laboratory of Biomaterials and Translational Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Li M; Center for Nanomedicine, Department of Pediatrics and Department of Allergy, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China. and Laboratory of Biomaterials and Translational Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China and Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou 510630, China.
Chen Z; Center for Nanomedicine, Department of Pediatrics and Department of Allergy, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China. .
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Źródło :
Biomaterials science [Biomater Sci] 2021 Jul 07; Vol. 9 (13), pp. 4746-4754. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Lung Injury*/drug therapy
Proto-Oncogene Proteins c-bcl-2*
Apoptosis ; Bridged Bicyclo Compounds, Heterocyclic ; Humans ; Nanomedicine ; Neutrophils ; Sulfonamides
Czasopismo naukowe
Tytuł :
Synergistic Effect of the Long-Term Overexpression of Bcl-2 and BDNF Lentiviral in Cell Protecting against Death and Generating TH Positive and CHAT Positive Cells from MSC.
Autorzy :
Borkowska P; Department of Medical Genetics, Medical University of Silesia, 41-200 Sosnowiec, Poland.
Zielinska A; Department of Medical Genetics, Medical University of Silesia, 41-200 Sosnowiec, Poland.
Paul-Samojedny M; Department of Medical Genetics, Medical University of Silesia, 41-200 Sosnowiec, Poland.
Stojko R; Chair and Department of Gynecology, Obstetrics and Oncological Gynecology, Medical University of Silesia, 40-211 Katowice, Poland.
Kowalski J; Department of Medical Genetics, Medical University of Silesia, 41-200 Sosnowiec, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 30; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation*
Brain-Derived Neurotrophic Factor/*biosynthesis
Dopaminergic Neurons/*metabolism
Mesenchymal Stem Cells/*metabolism
Proto-Oncogene Proteins c-bcl-2/*biosynthesis
Brain-Derived Neurotrophic Factor/genetics ; Dopaminergic Neurons/cytology ; Humans ; Lentivirus ; Mesenchymal Stem Cells/cytology ; Proto-Oncogene Proteins c-bcl-2/genetics ; Transduction, Genetic
Czasopismo naukowe
Tytuł :
Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis.
Autorzy :
Wang J; Department of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Thomas HR; Department of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Li Z; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Yeo NCF; Department of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Scott HE; Department of Biology, University of Alabama at Birmingham Collage of Arts and Sciences Department and Genetics Department, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Dang N; Department of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Hossain MI; Department of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Andrabi SA; Department of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.; Department of Neurology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Parant JM; Department of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA. .
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Źródło :
Cell death & disease [Cell Death Dis] 2021 Jun 30; Vol. 12 (7), pp. 659. Date of Electronic Publication: 2021 Jun 30.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*/drug effects
Apoptosis*/radiation effects
DNA Damage*
Endoplasmic Reticulum Stress*/drug effects
Oxidative Stress*/drug effects
Apoptosis Regulatory Proteins/*metabolism
Phosphoproteins/*metabolism
Proto-Oncogene Proteins/*metabolism
Proto-Oncogene Proteins c-bcl-2/*metabolism
Trans-Activators/*metabolism
Tumor Suppressor Protein p53/*metabolism
Zebrafish Proteins/*metabolism
Animals ; Animals, Genetically Modified ; Apoptosis Regulatory Proteins/genetics ; Gene Expression Regulation ; Macrolides/pharmacology ; Phosphoproteins/genetics ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-mdm2/genetics ; Proto-Oncogene Proteins c-mdm2/metabolism ; Signal Transduction ; Tetradecanoylphorbol Acetate/pharmacology ; Thapsigargin/pharmacology ; Time Factors ; Trans-Activators/genetics ; Transcription, Genetic ; Tumor Suppressor Protein p53/genetics ; X-Rays ; Zebrafish/genetics ; Zebrafish Proteins/genetics
Czasopismo naukowe
Tytuł :
Functional Analysis of the Promoter Regions of Two Apoptosis-Related Genes ( Bcl-2 and Cycs ) and Their Regulation by Zn in Yellow Catfish.
Autorzy :
He Y; Laboratory of Molecular Nutrition for Aquatic Economic Animals, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Zhao T; Laboratory of Molecular Nutrition for Aquatic Economic Animals, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Chen F; Laboratory of Molecular Nutrition for Aquatic Economic Animals, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Song C; Laboratory of Molecular Nutrition for Aquatic Economic Animals, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Zhong C; Laboratory of Molecular Nutrition for Aquatic Economic Animals, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Luo Z; Laboratory of Molecular Nutrition for Aquatic Economic Animals, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 11; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 11.
Typ publikacji :
Journal Article
MeSH Terms :
Promoter Regions, Genetic*
Apoptosis/*genetics
Catfishes/*genetics
Cytochromes c/*genetics
Proto-Oncogene Proteins c-bcl-2/*genetics
Zinc/*pharmacology
Animals ; Apoptosis/drug effects ; Base Sequence ; Binding Sites ; Cytochromes c/metabolism ; Gene Expression Regulation/drug effects ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Sequence Deletion
Czasopismo naukowe
Tytuł :
Zinc Modulates the Response to Apoptosis in an In Vitro Model with High Glucose and Inflammatory Stimuli in C2C12 Cells.
Autorzy :
Andrews-Guzmán M; Micronutrient Laboratory, Institute of Nutrition and Food Technology, University of Chile, El Líbano 5524, Macul, Santiago, Chile.
Ruz M; Department of Nutrition, Faculty of Medicine, University of Chile, Avenida Independencia 1027, Independencia, Santiago, Chile.
Arredondo-Olguín M; Micronutrient Laboratory, Institute of Nutrition and Food Technology, University of Chile, El Líbano 5524, Macul, Santiago, Chile. .
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Źródło :
Biological trace element research [Biol Trace Elem Res] 2021 Jun; Vol. 199 (6), pp. 2288-2294. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Journal Article
MeSH Terms :
Proto-Oncogene Proteins c-bcl-2*
Zinc*/pharmacology
Apoptosis ; Glucose/pharmacology ; bcl-2-Associated X Protein/genetics ; bcl-X Protein/genetics
Czasopismo naukowe

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