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Tytuł :
SARS-CoV-2 Proteins Bind to Hemoglobin and Its Metabolites.
Autorzy :
Lechuga GC; FIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Population Diseases (INCT-IDPN), Rio de Janeiro 21040-900, RJ, Brazil.; Laboratory of Celular Ultrastructure, FIOCRUZ, Oswaldo Cruz Institute, Rio de Janeiro 21040-900, RJ, Brazil.
Souza-Silva F; FIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Population Diseases (INCT-IDPN), Rio de Janeiro 21040-900, RJ, Brazil.; Biology and Heath Science Faculty, Iguaçu University, Nova Iguaçu 26260-045, RJ, Brazil.
Sacramento CQ; FIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Population Diseases (INCT-IDPN), Rio de Janeiro 21040-900, RJ, Brazil.; Laboratory of Immunopharmacology, FIOCRUZ, Oswaldo Cruz Institute, Rio de Janeiro 21040-900, RJ, Brazil.
Trugilho MRO; FIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Population Diseases (INCT-IDPN), Rio de Janeiro 21040-900, RJ, Brazil.; Laboratory of Toxinology, FIOCRUZ, Oswaldo Cruz Institute, Rio de Janeiro 21040-900, RJ, Brazil.
Valente RH; Laboratory of Toxinology, FIOCRUZ, Oswaldo Cruz Institute, Rio de Janeiro 21040-900, RJ, Brazil.
Napoleão-Pêgo P; FIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Population Diseases (INCT-IDPN), Rio de Janeiro 21040-900, RJ, Brazil.
Dias SSG; Laboratory of Immunopharmacology, FIOCRUZ, Oswaldo Cruz Institute, Rio de Janeiro 21040-900, RJ, Brazil.
Fintelman-Rodrigues N; FIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Population Diseases (INCT-IDPN), Rio de Janeiro 21040-900, RJ, Brazil.; Laboratory of Immunopharmacology, FIOCRUZ, Oswaldo Cruz Institute, Rio de Janeiro 21040-900, RJ, Brazil.
Temerozo JR; Laboratory of Thymus Research, FIOCRUZ, Oswaldo Cruz Institute, Rio de Janeiro 21040-900, RJ, Brazil.; FIOCRUZ, National Institute for Science and Technology on Neuroimmunomodulation (INCT/NIM), Rio de Janeiro 21040-900, RJ, Brazil.
Carels N; FIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Population Diseases (INCT-IDPN), Rio de Janeiro 21040-900, RJ, Brazil.; Biology and Heath Science Faculty, Iguaçu University, Nova Iguaçu 26260-045, RJ, Brazil.
Alves CR; Laboratory of Molecular Biology and Endemic Diseases, FIOCRUZ, Oswaldo Cruz Institute, Rio de Janeiro 21040-900, RJ, Brazil.
Pereira MCS; Laboratory of Celular Ultrastructure, FIOCRUZ, Oswaldo Cruz Institute, Rio de Janeiro 21040-900, RJ, Brazil.
Provance DW Jr; FIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Population Diseases (INCT-IDPN), Rio de Janeiro 21040-900, RJ, Brazil.
Souza TML; FIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Population Diseases (INCT-IDPN), Rio de Janeiro 21040-900, RJ, Brazil.; Laboratory of Immunopharmacology, FIOCRUZ, Oswaldo Cruz Institute, Rio de Janeiro 21040-900, RJ, Brazil.
De-Simone SG; FIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Population Diseases (INCT-IDPN), Rio de Janeiro 21040-900, RJ, Brazil.; Department of Cellular and Molecular Biology, Biology Institute, Federal Fluminense University, Niterói 24020-141, RJ, Brazil.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 21; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 21.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*etiology
Hemoglobins/*metabolism
SARS-CoV-2/*metabolism
Viral Nonstructural Proteins/*metabolism
Viral Structural Proteins/*metabolism
COVID-19/blood ; Hemin/metabolism ; Hemoglobins/ultrastructure ; Humans ; Molecular Docking Simulation ; Protein Binding ; Protein Domains ; Proteomics ; Protoporphyrins/metabolism ; SARS-CoV-2/pathogenicity ; Viral Nonstructural Proteins/ultrastructure ; Viral Structural Proteins/ultrastructure ; Virus Attachment ; Virus Replication
Czasopismo naukowe
Tytuł :
Nicastrin-Like, a Novel Transmembrane Protein from Trypanosoma cruzi Associated to the Flagellar Pocket.
Autorzy :
Lechuga GC; FIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Diseases Populations (INCT-IDPN), Rio de Janeiro 21040-900, Brazil.
Napoleão-Pêgo P; FIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Diseases Populations (INCT-IDPN), Rio de Janeiro 21040-900, Brazil.
Gomes LR; FIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Diseases Populations (INCT-IDPN), Rio de Janeiro 21040-900, Brazil.
da Matta Durans A; FIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Diseases Populations (INCT-IDPN), Rio de Janeiro 21040-900, Brazil.
Provance DW Jr; FIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Diseases Populations (INCT-IDPN), Rio de Janeiro 21040-900, Brazil.; FIOCRUZ, Interdisciplinary Medical Research Laboratory, Oswaldo Cruz Institute, Rio de Janeiro 21040-900, Brazil.
De-Simone SG; FIOCRUZ, Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Diseases Populations (INCT-IDPN), Rio de Janeiro 21040-900, Brazil.; Department of Cellular and Molecular Biology, Biology Institute, Federal Fluminense University, Niterói 24020-141, Brazil.
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Źródło :
Microorganisms [Microorganisms] 2021 Aug 17; Vol. 9 (8). Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Performance assessment of a multi-epitope chimeric antigen for the serological diagnosis of acute Mayaro fever.
Autorzy :
Napoleão-Pêgo P; Oswaldo Cruz Foundation (FIOCRUZ), Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation in Diseases of Neglected Populations (INCT-IDPN), Brazil Av 4365, Leonidas Deane Building, Room 309, Rio de Janeiro, RJ, 21040-900, Brazil.
Carneiro FRG; Oswaldo Cruz Foundation (FIOCRUZ), Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation in Diseases of Neglected Populations (INCT-IDPN), Brazil Av 4365, Leonidas Deane Building, Room 309, Rio de Janeiro, RJ, 21040-900, Brazil.; Laboratory of Interdisplinary Medical Research (LIPMED), Oswaldo Cruz Institute (IOC), FIOCRUZ, Brazil Av 4365, Rio de Janeiro, RJ, 21040-900, Brazil.
Durans AM; Oswaldo Cruz Foundation (FIOCRUZ), Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation in Diseases of Neglected Populations (INCT-IDPN), Brazil Av 4365, Leonidas Deane Building, Room 309, Rio de Janeiro, RJ, 21040-900, Brazil.; Laboratory of Interdisplinary Medical Research (LIPMED), Oswaldo Cruz Institute (IOC), FIOCRUZ, Brazil Av 4365, Rio de Janeiro, RJ, 21040-900, Brazil.
Gomes LR; Oswaldo Cruz Foundation (FIOCRUZ), Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation in Diseases of Neglected Populations (INCT-IDPN), Brazil Av 4365, Leonidas Deane Building, Room 309, Rio de Janeiro, RJ, 21040-900, Brazil.
Morel CM; Oswaldo Cruz Foundation (FIOCRUZ), Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation in Diseases of Neglected Populations (INCT-IDPN), Brazil Av 4365, Leonidas Deane Building, Room 309, Rio de Janeiro, RJ, 21040-900, Brazil.
Provance DW Jr; Oswaldo Cruz Foundation (FIOCRUZ), Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation in Diseases of Neglected Populations (INCT-IDPN), Brazil Av 4365, Leonidas Deane Building, Room 309, Rio de Janeiro, RJ, 21040-900, Brazil.; Laboratory of Interdisplinary Medical Research (LIPMED), Oswaldo Cruz Institute (IOC), FIOCRUZ, Brazil Av 4365, Rio de Janeiro, RJ, 21040-900, Brazil.
De-Simone SG; Oswaldo Cruz Foundation (FIOCRUZ), Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation in Diseases of Neglected Populations (INCT-IDPN), Brazil Av 4365, Leonidas Deane Building, Room 309, Rio de Janeiro, RJ, 21040-900, Brazil. .; Biology Institute, Federal Fluminense University, Outeiro de São Joao Batista S/N, Niterói, RJ, 24020-141, Brazil. .
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Źródło :
Scientific reports [Sci Rep] 2021 Jul 28; Vol. 11 (1), pp. 15374. Date of Electronic Publication: 2021 Jul 28.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Small Angle X-ray Scattering, Molecular Modeling, and Chemometric Studies from a Thrombin-Like (Lmr-47) Enzyme of Lachesis m. rhombeata Venom.
Autorzy :
De-Simone SG; FIOCRUZ, Center of Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Diseases Population (INCT-IDPN), Rio de Janeiro 21040-900, Brazil.; Department of Cellular and Molecular Biology, Biology Institute, Federal Fluminense University, Niterói 24020-141, Brazil.
Lechuga GC; FIOCRUZ, Center of Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Diseases Population (INCT-IDPN), Rio de Janeiro 21040-900, Brazil.
Napoleão-Pêgo P; FIOCRUZ, Center of Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Diseases Population (INCT-IDPN), Rio de Janeiro 21040-900, Brazil.
Gomes LR; FIOCRUZ, Center of Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Diseases Population (INCT-IDPN), Rio de Janeiro 21040-900, Brazil.
Provance DW Jr; FIOCRUZ, Center of Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation on Neglected Diseases Population (INCT-IDPN), Rio de Janeiro 21040-900, Brazil.; Interdisciplinary Medical Research Laboratory, Oswaldo Cruz Institute/FIOCRUZ, Rio de Janeiro 21040-900, Brazil.
Nirello VD; Faculty of Pharmacy, Federal of Rio de Janeiro University, Rio de Janeiro 21949-900, Brazil.
Sodero ACR; Faculty of Pharmacy, Federal of Rio de Janeiro University, Rio de Janeiro 21949-900, Brazil.
Guedes HLM; Interdisciplinary Medical Research Laboratory, Oswaldo Cruz Institute/FIOCRUZ, Rio de Janeiro 21040-900, Brazil.; Laboratory of Immunopharmacology, Federal of Rio de Janeiro University, Duque de Caxias 25245-390, Brazil.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 28; Vol. 26 (13). Date of Electronic Publication: 2021 Jun 28.
Typ publikacji :
Journal Article
MeSH Terms :
Crotalinae*
Molecular Docking Simulation*
Crotalid Venoms/*enzymology
Reptilian Proteins/*chemistry
Thrombin/*chemistry
Animals ; Scattering, Small Angle ; X-Ray Diffraction
Czasopismo naukowe
Tytuł :
Lectin Affinity Chromatography: An Efficient Method to Purify Horse IgG3.
Autorzy :
De-Simone SG; FIOCRUZ, Center for Technological Development in Health (CDTS)/National Institute of Science and Technology for Innovation on Neglected of Population Diseases (INCT-INDP), Rio de Janeiro, RJ, Brazil. .; FIOCRUZ, Oswaldo Cruz Institute, Laboratory of Experimental and Computational Biochemistry of Pharmaceuticals, Rio de Janeiro, RJ, Brazil. .; Department of Cellular and Molecular Biology, Biology Institute, Federal Fluminense University, Niterói, RJ, Brazil. .
Provance DW Jr; FIOCRUZ, Center for Technological Development in Health (CDTS)/National Institute of Science and Technology for Innovation on Neglected of Population Diseases (INCT-INDP), Rio de Janeiro, RJ, Brazil.; FIOCRUZ, Oswaldo Cruz Institute, Interdisciplinar Laboratory of Medical Research, Rio de Janeiro, RJ, Brazil.
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2178, pp. 301-310.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatography, Affinity*
Horses*
Immunoglobulin E/*isolation & purification
Immunoglobulin G/*isolation & purification
Plant Lectins/*chemistry
Animals ; Humans ; Immunoglobulin E/chemistry ; Immunoglobulin G/chemistry
Czasopismo naukowe
Tytuł :
Zika Induces Human Placental Damage and Inflammation.
Autorzy :
Rabelo K; Laboratório de Ultraestrutura e Biologia Tecidual, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
de Souza LJ; Faculdade de Medicina de Campos, Rio de Janeiro, Brazil.
Salomão NG; Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil.
Machado LN; Faculdade de Medicina de Campos, Rio de Janeiro, Brazil.
Pereira PG; Laboratório de Ultraestrutura e Biologia Tecidual, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Portari EA; Anatomia Patológica, Instituto Fernandes Figueira, Rio de Janeiro, Brazil.
Basílio-de-Oliveira R; Anatomia Patológica, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Dos Santos FB; Laboratório de Imunologia Viral, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil.
Neves LD; Hospital Geral Dr. Beda, CEPLIN - Uti Neonatal Nicola Albano, Rio de Janeiro, Brazil.
Morgade LF; Hospital Geral Dr. Beda, CEPLIN - Uti Neonatal Nicola Albano, Rio de Janeiro, Brazil.
Provance DW Jr; Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil.; Centro de Desenvolvimento Tecnológico em Saúde, Fiocruz, Rio de Janeiro, Brazil.
Higa LM; Laboratório de Virologia Molecular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Tanuri A; Laboratório de Virologia Molecular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
de Carvalho JJ; Laboratório de Ultraestrutura e Biologia Tecidual, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Paes MV; Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Sep 01; Vol. 11, pp. 2146. Date of Electronic Publication: 2020 Sep 01 (Print Publication: 2020).
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Microcephaly/*etiology
Placenta/*pathology
Pregnancy Complications, Infectious/*pathology
Zika Virus/*pathogenicity
Zika Virus Infection/*pathology
Adult ; Antigens, Viral/analysis ; Brain-Derived Neurotrophic Factor/biosynthesis ; Brain-Derived Neurotrophic Factor/genetics ; Brazil/epidemiology ; Case-Control Studies ; Cesarean Section ; Collagen/biosynthesis ; Collagen/genetics ; Cytokines/biosynthesis ; Cytokines/genetics ; Disease Outbreaks ; Female ; Humans ; Inclusion Bodies, Viral ; Infant, Newborn ; Male ; Matrix Metalloproteinases/biosynthesis ; Matrix Metalloproteinases/genetics ; Placenta/metabolism ; Placenta/virology ; Pregnancy ; Pregnancy Complications, Infectious/metabolism ; Pregnancy Complications, Infectious/virology ; Trophoblasts/ultrastructure ; Trophoblasts/virology ; Virus Replication ; Young Adult ; Zika Virus/immunology ; Zika Virus/isolation & purification ; Zika Virus/physiology ; Zika Virus Infection/epidemiology ; Zika Virus Infection/immunology
Czasopismo naukowe
Tytuł :
Application of WHO International Biological Reference Standards to evaluate commercial serological tests for chronic Chagas disease.
Autorzy :
Sáez-Alquezar A; Programa Nacional de Controle de Qualidade, Sociedade Brasileira de Análises Clínicas, Rio de Janeiro, RJ, Brasil.
Junqueira ACV; Laboratório de Doenças Parasitárias, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brazil.
Durans ADM; Centro de Desenvolvimento Tecnológico em Saúde, Fundação Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brazil.
Guimarães AV; Programa Nacional de Controle de Qualidade, Sociedade Brasileira de Análises Clínicas, Rio de Janeiro, RJ, Brasil.
Corrêa JA; Programa Nacional de Controle de Qualidade, Sociedade Brasileira de Análises Clínicas, Rio de Janeiro, RJ, Brasil.
Provance DW Jr; Centro de Desenvolvimento Tecnológico em Saúde, Fundação Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brazil.
Cabello PH; Laboratório de Genética Humana, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brazil.
Coura JR; Laboratório de Doenças Parasitárias, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brazil.
Viñas PA; Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.
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Źródło :
Memorias do Instituto Oswaldo Cruz [Mem Inst Oswaldo Cruz] 2020; Vol. 115, pp. e200214. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article
MeSH Terms :
Chagas Disease/*diagnosis
Serologic Tests/*standards
Trypanosoma cruzi/*isolation & purification
Antibodies, Protozoan/blood ; Chagas Disease/parasitology ; Humans ; Immunoassay/methods ; Reference Standards ; Serologic Tests/methods ; Trypanosoma cruzi/immunology ; World Health Organization
Czasopismo naukowe
Tytuł :
Physical exercise stimulates salivary secretion of cystatins.
Autorzy :
Sant'Anna ML; Institute of Medical Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Physical Activity Biosciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Almirante Sylvio de Carmargo Training Center, Brazilian Navy, Rio de Janeiro, Brazil.
Oliveira LT; Institute of Medical Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Gomes DV; Department of Physical Activity Biosciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Marques STF; Naval Sports Commisson, Brazilian Navy, Rio de Janeiro, Brazil.
Provance DW Jr; Center for Technological Development in Health, Oswaldo Cruz Insitute, Rio de Janeiro, Brazil.
Sorenson MM; Institute of Medical Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Salerno VP; Department of Physical Activity Biosciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
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Źródło :
PloS one [PLoS One] 2019 Oct 24; Vol. 14 (10), pp. e0224147. Date of Electronic Publication: 2019 Oct 24 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Exercise*
Salivary Cystatins/*metabolism
Submandibular Gland/*metabolism
Adrenergic beta-Agonists/pharmacology ; Adrenergic beta-Antagonists/pharmacology ; Adult ; Cells, Cultured ; Humans ; Male ; Submandibular Gland/cytology ; Submandibular Gland/drug effects
Czasopismo naukowe
Tytuł :
Separation of Volatile Metabolites from the Leaf-Derived Essential Oil of Piper mollicomum Kunth (Piperaceae) by High-Speed Countercurrent Chromatography.
Autorzy :
Marques AM; Laboratório de Produtos Naturais, PN3, FarManguinhos, FIOCRUZ, 21045-900 Rio de Janeiro, Brazil. .
Peixoto ACC; Instituto de Pesquisas de Produtos Naturais (IPPN), Universidade Federal do Rio de Janeiro (UFRJ), 21941-902 Rio de Janeiro, Brazil. .
Provance DW Jr; Centro de Desenvolvimento Tecnológico em Saúde (CDTS/Fiocruz), 21045-360 Rio de Janeiro, Brasil. bill.provance@cdts.fiocruz.br.
Kaplan MAC; Instituto de Pesquisas de Produtos Naturais (IPPN), Universidade Federal do Rio de Janeiro (UFRJ), 21941-902 Rio de Janeiro, Brazil. .
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2018 Nov 23; Vol. 23 (12). Date of Electronic Publication: 2018 Nov 23.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatography*/methods
Metabolomics*/methods
Oils, Volatile/*chemistry
Piper/*chemistry
Plant Leaves/*chemistry
Volatile Organic Compounds/*chemistry
Gas Chromatography-Mass Spectrometry ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Solvents
Czasopismo naukowe
Tytuł :
Purification of equine IgG3 by lectin affinity and an interaction analysis via microscale thermophoresis.
Autorzy :
De-Simone SG; FIOCRUZ, Center for Technological Development in Health (CDTS)/ National Institute of Science and Technology for Innovation in Neglected Diseases (INCT-IDN), Rio de Janeiro, RJ, Brazil; FIOCRUZ, Oswaldo Cruz Institute, Laboratory of Experimental and Computational Biochemistry of Pharmaceuticals, Rio de Janeiro, RJ, Brazil; Federal Fluminense University, Biology Institute, Department of Molecular and Cellular Biology, Niterói, RJ, Brazil. Electronic address: .
Nascimento HJ; FIOCRUZ, Institute of Technology in Immunobiology, Rio de Janeiro, RJ, Brazil.
Prado IC; FIOCRUZ, Center for Technological Development in Health (CDTS)/ National Institute of Science and Technology for Innovation in Neglected Diseases (INCT-IDN), Rio de Janeiro, RJ, Brazil.
Aguiar AS; Vital Brazil Institute, Research and Development Laboratory, Niterói, RJ, Brazil.
Melgarejo AR; Vital Brazil Institute, Research and Development Laboratory, Niterói, RJ, Brazil.
Pina JLS; FIOCRUZ, Oswaldo Cruz Institute, Laboratory of Experimental and Computational Biochemistry of Pharmaceuticals, Rio de Janeiro, RJ, Brazil.
Ferreira PF; FIOCRUZ, Center for Technological Development in Health (CDTS)/ National Institute of Science and Technology for Innovation in Neglected Diseases (INCT-IDN), Rio de Janeiro, RJ, Brazil.
Provance DW Jr; FIOCRUZ, Center for Technological Development in Health (CDTS)/ National Institute of Science and Technology for Innovation in Neglected Diseases (INCT-IDN), Rio de Janeiro, RJ, Brazil.
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Źródło :
Analytical biochemistry [Anal Biochem] 2018 Nov 15; Vol. 561-562, pp. 27-31. Date of Electronic Publication: 2018 Sep 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Temperature*
Immunoglobulin G/*chemistry
Immunoglobulin G/*isolation & purification
Lectins/*chemistry
Animals ; Chromatography, Affinity ; Horses ; Immunoglobulin G/immunology ; Lectins/immunology ; Plant Lectins/chemistry
Czasopismo naukowe
Tytuł :
Impairing the function of MLCK, myosin Va or myosin Vb disrupts Rhinovirus B14 replication.
Autorzy :
Real-Hohn A; Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Departamento de Biociências da Atividade Física, Escola de Educação Física e Desportos, Universidade Federal Rio do Janeiro, Rio de Janeiro, Brazil.; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Rio de Janeiro, RJ, Brazil.
Provance DW Jr; Center for Technological Development in Health, National Institute of Science and Technology for Innovation in Diseases of Neglected Populations, Oswaldo Cruz Foundation/Fiocruz, Rio de Janeiro, Brazil.
Gonçalves RB; Departamento de Bioquímica, Instituto Biomédico, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Rio de Janeiro, RJ, Brazil.
Denani CB; Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Rio de Janeiro, RJ, Brazil.
de Oliveira AC; Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Rio de Janeiro, RJ, Brazil.
Salerno VP; Departamento de Biociências da Atividade Física, Escola de Educação Física e Desportos, Universidade Federal Rio do Janeiro, Rio de Janeiro, Brazil.
Oliveira Gomes AM; Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. .; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Rio de Janeiro, RJ, Brazil. .
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Źródło :
Scientific reports [Sci Rep] 2017 Dec 07; Vol. 7 (1), pp. 17153. Date of Electronic Publication: 2017 Dec 07.
Typ publikacji :
Journal Article
MeSH Terms :
Enterovirus Infections/*prevention & control
Methylmalonic Acid/*analogs & derivatives
Myosin Heavy Chains/*antagonists & inhibitors
Myosin Type V/*antagonists & inhibitors
Myosin-Light-Chain Kinase/*antagonists & inhibitors
Virus Internalization/*drug effects
Virus Replication/*drug effects
Actin Cytoskeleton/metabolism ; Enterovirus Infections/metabolism ; Enterovirus Infections/virology ; HeLa Cells ; Humans ; Methylmalonic Acid/pharmacology ; Phosphorylation ; Rhinovirus/drug effects ; Rhinovirus/physiology
Czasopismo naukowe
Tytuł :
Ultrasensitive and rapid immuno-detection of human IgE anti-therapeutic horse sera using an electrochemical immunosensor.
Autorzy :
Prado IC; FIOCRUZ, Center for Technological Development in Health (CDTS)/National Institute of Science and Technology on Innovation in Neglected Population Diseases (INCT-IDPN) FIOCRUZ, Rio de Janeiro, RJ, Brazil; Federal Fluminense University, Chemistry Institute, Analytical Chemistry Department, Niterói, Rio de Janeiro, Brazil.
Souza ALA; FIOCRUZ, Oswaldo Cruz Institute, Laboratory of Experimental and Computational Biochemistry of Pharmaceuticals, Rio de Janeiro, RJ, Brazil.
Provance DW Jr; FIOCRUZ, Center for Technological Development in Health (CDTS)/National Institute of Science and Technology on Innovation in Neglected Population Diseases (INCT-IDPN) FIOCRUZ, Rio de Janeiro, RJ, Brazil.
Cassella RJ; Federal Fluminense University, Chemistry Institute, Analytical Chemistry Department, Niterói, Rio de Janeiro, Brazil.
De-Simone SG; FIOCRUZ, Center for Technological Development in Health (CDTS)/National Institute of Science and Technology on Innovation in Neglected Population Diseases (INCT-IDPN) FIOCRUZ, Rio de Janeiro, RJ, Brazil; FIOCRUZ, Oswaldo Cruz Institute, Laboratory of Experimental and Computational Biochemistry of Pharmaceuticals, Rio de Janeiro, RJ, Brazil; Federal Fluminense University, Biology Institute, Cellular and Molecular Department, Niterói, Rio de Janeiro, Brazil. Electronic address: .
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Źródło :
Analytical biochemistry [Anal Biochem] 2017 Dec 01; Vol. 538, pp. 13-19. Date of Electronic Publication: 2017 Sep 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Electrochemical Techniques*
Biosensing Techniques/*methods
Immunoassay/*methods
Immunoglobulin E/*analysis
Animals ; Antibodies, Anti-Idiotypic/immunology ; Chitosan/chemistry ; Electrodes ; Gold/chemistry ; Horses ; Humans ; Immunoglobulin E/immunology ; Immunoglobulin G/immunology ; Immunoglobulin G/isolation & purification ; Limit of Detection ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Echinodorus grandiflorus: Ethnobotanical, phytochemical and pharmacological overview of a medicinal plant used in Brazil.
Autorzy :
Marques AM; Fundação Oswaldo Cruz (FIOCRUZ), Departamento de Produtos Naturais, Laboratório de Produtos Naturais, PN3, Farmanguinhos, CEP 21041-250, Rua Sizenando Nabuco, 100, Rio de Janeiro, RJ, Brazil. Electronic address: .
Provance DW Jr; Fundação Oswaldo Cruz (FIOCRUZ), Centro de Desenvolvimento Tecnológico em Saúde (CDTS), Rio de Janeiro, Brazil.
Kaplan MAC; Instituto de Pesquisas de Produtos Naturais Walter Mors (IPPN), Universidade Federal do Rio de Janeiro, CEP 21.941-590, Rio de Janeiro, RJ, Brazil.
Figueiredo MR; Fundação Oswaldo Cruz (FIOCRUZ), Departamento de Produtos Naturais, Laboratório de Produtos Naturais, PN3, Farmanguinhos, CEP 21041-250, Rua Sizenando Nabuco, 100, Rio de Janeiro, RJ, Brazil.
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2017 Nov; Vol. 109 (Pt 2), pp. 1032-1047. Date of Electronic Publication: 2017 Mar 18.
Typ publikacji :
Journal Article; Review; Systematic Review
MeSH Terms :
Alismataceae/*chemistry
Phytochemicals/*chemistry
Phytochemicals/*pharmacology
Plant Extracts/*chemistry
Plant Extracts/*pharmacology
Plants, Medicinal/*chemistry
Animals ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/isolation & purification ; Anti-Inflammatory Agents/pharmacology ; Antihypertensive Agents/chemistry ; Antihypertensive Agents/isolation & purification ; Antihypertensive Agents/pharmacology ; Brazil ; Humans ; Phytochemicals/isolation & purification ; Plant Extracts/isolation & purification
Czasopismo naukowe
Tytuł :
Development of an elisa for the diagnosis of reactive IgE antibodies anti-therapeutic horse sera.
Autorzy :
De-Simone SG; FIOCRUZ, Center of Technological Development in Health (CDTS)/National Institute of Science and Technology for Innovation on Neglected Diseases (INCT-IDN), Rio of Janeiro, RJ, Brazil; FIOCRUZ, Oswaldo Cruz Institute, Laboratory of Experimental and Computational Biochemistry of Pharmaceuticals, Rio de Janeiro, RJ, Brazil; Federal Fluminense University, Biology Institute, Department of Cellular and Molecular Biology, Niterói, Rio Janeiro, Brazil. Electronic address: .
Souza ALA; FIOCRUZ, Oswaldo Cruz Institute, Laboratory of Experimental and Computational Biochemistry of Pharmaceuticals, Rio de Janeiro, RJ, Brazil.
Aguiar AS; Vital Brazil Institute, Research and Development Laboratory, Niterói, RJ, Brazil.
Melgarejo AR; Vital Brazil Institute, Research and Development Laboratory, Niterói, RJ, Brazil.
Provance DW Jr; FIOCRUZ, Center of Technological Development in Health (CDTS)/National Institute of Science and Technology for Innovation on Neglected Diseases (INCT-IDN), Rio of Janeiro, RJ, Brazil.
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Źródło :
Toxicon : official journal of the International Society on Toxinology [Toxicon] 2017 Nov; Vol. 138, pp. 37-42. Date of Electronic Publication: 2017 Aug 12.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Anti-Idiotypic/*analysis
Enzyme-Linked Immunosorbent Assay/*methods
Immunoglobulin G/*analysis
Animals ; Antivenins/immunology ; Horses ; Humans ; Hypersensitivity/diagnosis ; Immunoglobulin G/immunology ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
HPV vaccines: a controversial issue?
Autorzy :
Nicol AF; Laboratório Interdisciplinar de Pesquisas Médicas, Fiocruz, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
Andrade CV; Instituto Nacional de Saúde da Mulher, Fiocruz, da Criança e do Adolescente Fernandes Figueira, Rio de Janeiro, RJ, Brasil.
Russomano FB; Instituto Nacional de Saúde da Mulher, Fiocruz, da Criança e do Adolescente Fernandes Figueira, Rio de Janeiro, RJ, Brasil.
Rodrigues LL; Instituto de Saúde Coletiva, Universidade Federal do Oeste do Pará, Santarém, PA, Brasil.
Oliveira NS; Laboratório Interdisciplinar de Pesquisas Médicas, Fiocruz, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
Provance DW Jr; Fiocruz, Centro de Desenvolvimento Tecnológico em Saúde, Rio de Janeiro, RJ, Brasil.
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Źródło :
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas [Braz J Med Biol Res] 2016; Vol. 49 (5), pp. e5060. Date of Electronic Publication: 2016 Apr 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Vaccination*/adverse effects
Papillomavirus Infections/*prevention & control
Papillomavirus Vaccines/*administration & dosage
Female ; Humans ; Male ; Papillomavirus Vaccines/adverse effects
Czasopismo naukowe
Tytuł :
Phenotypic variability confirmed by nuclear ribosomal DNA suggests a possible natural hybrid zone of Triatoma brasiliensis species complex.
Autorzy :
Costa J; Laboratório de Biodiversidade Entomológica,Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brazil. Electronic address: .
Bargues MD; Dep. de Parasitología, Facultad de Farmacia, Univ. de Valencia, Burjassot, Valencia, Spain.
Neiva VL; Laboratório de Biodiversidade Entomológica,Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
Lawrence GG; Entomology Branch, Div. Parasitic Diseases, CDC, Atlanta, GA, USA.
Gumiel M; Laboratório de Fisiologia e Bioquímica de Insetos Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
Oliveira G; Secretaria de Vigilância em Saúde, Pernambuco, Brazil.
Cabello P; Laboratório de Genética Humana, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
Lima MM; Laboratório de Eco-epidemiologia da Doença de Chagas, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
Dotson E; Entomology Branch, Div. Parasitic Diseases, CDC, Atlanta, GA, USA.
Provance DW Jr; Centro de Des. Tecnológico em Saúde/Fiocruz, CDTS, Rio de Janeiro, RJ, Brazil.
Almeida CE; Univers. Est. Paulista Júlio de Mesquita Filho, Araquara, SP, Prog. de Pós-Graduação em Ecologia e Monitoramento Ambiental (PPGEMA), UFPB, Campus IV, Paraíba, Brazil. Electronic address: .
Mateo L; Dep. de Parasitología, Facultad de Farmacia, Univ. de Valencia, Burjassot, Valencia, Spain.
Mas-Coma S; Dep. de Parasitología, Facultad de Farmacia, Univ. de Valencia, Burjassot, Valencia, Spain.
Dujardin JP; Institute de Recherche pour le Development, Montpelier, France.
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Źródło :
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2016 Jan; Vol. 37, pp. 77-87. Date of Electronic Publication: 2015 Oct 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Skin Pigmentation*
DNA, Ribosomal/*genetics
Triatoma/*genetics
Animals ; Brazil ; Chromatin/genetics ; Evolution, Molecular ; Phenotype ; Phylogeography ; Triatoma/classification
Czasopismo naukowe
Tytuł :
HPV vaccines: their pathology-based discovery, benefits, and adverse effects.
Autorzy :
Nicol AF; Laboratório Interdisciplinar de Pesquisas Médicas, IOC, Fiocruz, Rio de Janeiro, Brasil.
de Andrade CV; Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira - Fundação Oswaldo Cruz.
Russomano FB; Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira - Fundação Oswaldo Cruz.
Rodrigues LS; Instituto de Saúde Coletiva, Universidade Federal do Oeste do Pará and Post-graduate Student at Medicina Tropical - IOC - Fiocruz - Rio de Janeiro, Brasil.
Oliveira NS; Laboratório Interdisciplinar de Pesquisas Médicas, IOC, Fiocruz, Rio de Janeiro, Brasil.
Provance DW Jr; Center for Technology Development in Health (CDTS)/(INCT-IDPN)-Fiocruz, Brazil.
Nuovo GJ; Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. Electronic address: .
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Źródło :
Annals of diagnostic pathology [Ann Diagn Pathol] 2015 Dec; Vol. 19 (6), pp. 418-22. Date of Electronic Publication: 2015 Aug 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cervical Intraepithelial Neoplasia/*prevention & control
Condylomata Acuminata/*prevention & control
Papillomavirus Infections/*prevention & control
Papillomavirus Vaccines/*therapeutic use
Uterine Cervical Neoplasms/*prevention & control
Vaccination/*adverse effects
Cervical Intraepithelial Neoplasia/virology ; Condylomata Acuminata/virology ; Female ; Humans ; Male ; Papillomavirus Infections/virology ; Papillomavirus Vaccines/adverse effects ; Uterine Cervical Neoplasms/virology
Czasopismo naukowe
Tytuł :
Exogenous β-amyloid peptide interferes with GLUT4 localization in neurons.
Autorzy :
Oliveira LT; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, RJ 21944-590, Brazil; School of Physical Education and Sports, Federal University of Rio deJaneiro, RJ 21944-590, Brazil.
Leon GVO; School of Physical Education and Sports, Federal University of Rio deJaneiro, RJ 21944-590, Brazil.
Provance DW Jr; Center for the Development of Technology in Health (CDTS)/National Institute of Science and Technology for Innovation in Neglected Diseases (INCT-IDN), Oswaldo Cruz Foundation, RJ 21040-361, Brazil.
de Mello FG; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, RJ 21944-590, Brazil.
Sorenson MM; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, RJ 21944-590, Brazil.
Salerno VP; School of Physical Education and Sports, Federal University of Rio deJaneiro, RJ 21944-590, Brazil. Electronic address: .
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Źródło :
Brain research [Brain Res] 2015 Jul 30; Vol. 1615, pp. 42-50. Date of Electronic Publication: 2015 Apr 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid beta-Peptides/*metabolism
Glucose Transporter Type 4/*metabolism
Myosin Type V/*metabolism
Neurons/*metabolism
Alzheimer Disease/etiology ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/pharmacology ; Animals ; Cells, Cultured ; Chick Embryo ; Chickens ; Retina/cytology ; Retina/metabolism
Czasopismo naukowe
Tytuł :
IgE and IgG epitope mapping by microarray peptide-immunoassay reveals the importance and diversity of the immune response to the IgG3 equine immunoglobulin.
Autorzy :
De-Simone SG; Center for Technological Development in Health (CDTS) National Institute of Science and Technology for Innovation in Neglected Diseases (INCT-IDN), FIOCRUZ, Rio de Janeiro, RJ, Brazil; Molecular and Cellular Biology Department, Federal Fluminense University, Niterói, RJ, Brazil. Electronic address: .
Napoleão-Pêgo P; Molecular and Cellular Biology Department, Federal Fluminense University, Niterói, RJ, Brazil.
Teixeira-Pinto LA; Molecular and Cellular Biology Department, Federal Fluminense University, Niterói, RJ, Brazil.
Melgarejo AR; Research and Development Laboratory, Vital Brazil Institute, Niterói, RJ, Brazil.
Aguiar AS; Research and Development Laboratory, Vital Brazil Institute, Niterói, RJ, Brazil.
Provance DW Jr; Center for Technological Development in Health (CDTS) National Institute of Science and Technology for Innovation in Neglected Diseases (INCT-IDN), FIOCRUZ, Rio de Janeiro, RJ, Brazil.
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Źródło :
Toxicon : official journal of the International Society on Toxinology [Toxicon] 2014 Feb; Vol. 78, pp. 83-93. Date of Electronic Publication: 2013 Dec 13.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Variation*
Epitope Mapping/*veterinary
Horses/*immunology
Immunoglobulin E/*genetics
Immunoglobulin G/*genetics
Amino Acid Sequence ; Animals ; Antibodies/immunology ; Computational Biology ; Epitope Mapping/methods ; Horses/genetics ; Humans ; Immunoassay/veterinary ; Immunoglobulin G/immunology ; Microarray Analysis/veterinary ; Molecular Sequence Data
Czasopismo naukowe
Tytuł :
Chagas disease-specific antigens: characterization of epitopes in CRA/FRA by synthetic peptide mapping and evaluation by ELISA-peptide assay.
Autorzy :
Bottino CG
Gomes LP
Pereira JB
Coura JR
Provance DW Jr
De-Simone SG; Centro de Desenvolvimento Tecnológico em Saúde (CDTS)/Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças Negligenciadas (INCT-IDN), Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil. .
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Źródło :
BMC infectious diseases [BMC Infect Dis] 2013 Dec 03; Vol. 13, pp. 568. Date of Electronic Publication: 2013 Dec 03.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Protozoan/*chemistry
Antigens, Protozoan/*immunology
Chagas Disease/*parasitology
Enzyme-Linked Immunosorbent Assay/*methods
Trypanosoma cruzi/*immunology
Amino Acid Sequence ; Antibodies, Protozoan/immunology ; Antigens, Protozoan/genetics ; Chagas Disease/diagnosis ; Chagas Disease/immunology ; Enzyme-Linked Immunosorbent Assay/instrumentation ; Epitope Mapping ; Female ; Humans ; Male ; Molecular Sequence Data ; Peptide Mapping ; Peptides/chemical synthesis ; Peptides/genetics ; Peptides/immunology ; Trypanosoma cruzi/chemistry ; Trypanosoma cruzi/genetics
Czasopismo naukowe

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