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Tytuł :
Distinct viral reservoirs in individuals with spontaneous control of HIV-1.
Autorzy :
Jiang C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.
Lian X; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.
Gao C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Sun X; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Einkauf KB; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.
Chevalier JM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.
Chen SMY; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Hua S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Rhee B; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.
Chang K; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Blackmer JE; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Osborn M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Peluso MJ; Department of Medicine, University of California at San Francisco, San Francisco, CA, USA.
Hoh R; Department of Medicine, University of California at San Francisco, San Francisco, CA, USA.
Somsouk M; Department of Medicine, University of California at San Francisco, San Francisco, CA, USA.
Milush J; Department of Medicine, University of California at San Francisco, San Francisco, CA, USA.
Bertagnolli LN; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sweet SE; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Varriale JA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Burbelo PD; Dental Clinical Research Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Chun TW; National Institute of Allergies and Infectious Diseases, Bethesda, MD, USA.
Laird GM; Accelevir Diagnostics, Baltimore, MD, USA.
Serrao E; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Engelman AN; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Carrington M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Siliciano RF; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Siliciano JM; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Deeks SG; Department of Medicine, University of California at San Francisco, San Francisco, CA, USA.
Walker BD; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Lichterfeld M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Yu XG; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. .; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA. .
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Źródło :
Nature [Nature] 2020 Sep; Vol. 585 (7824), pp. 261-267. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Silencing*
HIV Infections/*genetics
HIV Infections/*virology
HIV-1/*genetics
Heterochromatin/*genetics
Proviruses/*genetics
Virus Integration/*genetics
Virus Latency/*genetics
Adult ; Aged ; Centromere/genetics ; Chromosomes, Human, Pair 19/genetics ; DNA, Satellite/genetics ; Female ; Genome, Viral/genetics ; HIV Infections/blood ; HIV-1/isolation & purification ; Heterochromatin/metabolism ; Humans ; Male ; Middle Aged ; Proviruses/isolation & purification ; Repressor Proteins/genetics ; Transcription Initiation Site
Czasopismo naukowe
Tytuł :
Use of synthetic oligonucleotides for determination of HTLV-1 proviral load by real-time PCR: a helpful alternative approach in the clinical management.
Autorzy :
Bandeira LM; Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
Puga MAM; Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
de Paula VS; Oswaldo Cruz Institute, Rio de Janeiro, RJ, Brazil.
Demarchi LHF; Central Public Health Laboratory, Lacen/MS, Campo Grande, MS, Brazil.
Lichs GGC; Central Public Health Laboratory, Lacen/MS, Campo Grande, MS, Brazil.
Domingos JA; Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
da Cunha RV; Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.; Oswaldo Cruz Foundation, Campo Grande, MS, Brazil.
Uehara SNO; Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
Motta-Castro ARC; Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.; Oswaldo Cruz Foundation, Campo Grande, MS, Brazil.
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Źródło :
Journal of applied microbiology [J Appl Microbiol] 2020 Sep; Vol. 129 (3), pp. 768-774. Date of Electronic Publication: 2020 Apr 08.
Typ publikacji :
Journal Article
MeSH Terms :
HTLV-I Infections/*diagnosis
Human T-lymphotropic virus 1/*isolation & purification
Proviruses/*isolation & purification
Real-Time Polymerase Chain Reaction/*methods
Viral Load/*methods
Adult ; DNA, Viral/genetics ; Disease Progression ; Genome, Viral/genetics ; HTLV-I Infections/blood ; HTLV-I Infections/virology ; Human T-lymphotropic virus 1/genetics ; Humans ; Leukocytes, Mononuclear/virology ; Middle Aged ; Oligonucleotides/chemical synthesis ; Oligonucleotides/genetics ; Prognosis ; Proviruses/genetics ; Real-Time Polymerase Chain Reaction/standards ; Viral Load/standards
Czasopismo naukowe
Tytuł :
Dynamic Shifts in the HIV Proviral Landscape During Long Term Combination Antiretroviral Therapy: Implications for Persistence and Control of HIV Infections.
Autorzy :
Anderson EM; HIV Dynamics and Replication Program, NCI, NIH, Frederick, MD 21702, USA.; Department of Biology, The Catholic University of America, Washington, DC 20064, USA.
Simonetti FR; HIV Dynamics and Replication Program, NCI, NIH, Frederick, MD 21702, USA.
Gorelick RJ; Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Hill S; HIV Dynamics and Replication Program, NCI, NIH, Frederick, MD 21702, USA.
Gouzoulis MA; HIV Dynamics and Replication Program, NCI, NIH, Frederick, MD 21702, USA.
Bell J; Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Rehm C; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20814, USA.
Pérez L; Virus Persistence and Dynamics Section, VRC, NIAID, NIH, Bethesda, MD 20814, USA.
Boritz E; Virus Persistence and Dynamics Section, VRC, NIAID, NIH, Bethesda, MD 20814, USA.
Wu X; Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Wells D; Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Hughes SH; HIV Dynamics and Replication Program, NCI, NIH, Frederick, MD 21702, USA.
Rao V; Department of Biology, The Catholic University of America, Washington, DC 20064, USA.
Coffin JM; Department of Biology, Tufts University, Boston, MA 02155, USA.
Kearney MF; HIV Dynamics and Replication Program, NCI, NIH, Frederick, MD 21702, USA.
Maldarelli F; HIV Dynamics and Replication Program, NCI, NIH, Frederick, MD 21702, USA.
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Źródło :
Viruses [Viruses] 2020 Jan 25; Vol. 12 (2). Date of Electronic Publication: 2020 Jan 25.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-HIV Agents/*therapeutic use
HIV Infections/*drug therapy
HIV Infections/*virology
HIV-1/*genetics
HIV-1/*isolation & purification
Leukocytes, Mononuclear/*virology
Proviruses/*isolation & purification
Antiretroviral Therapy, Highly Active ; CD4-Positive T-Lymphocytes/virology ; Cell Cycle Proteins/genetics ; DNA, Viral/blood ; DNA, Viral/genetics ; Defective Viruses/genetics ; Genes, gag ; HIV Long Terminal Repeat ; HIV-1/drug effects ; Humans ; Immunologic Memory ; Multiplex Polymerase Chain Reaction ; Proviruses/genetics ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/virology ; Time Factors ; Treatment Outcome ; Viral Load
Czasopismo naukowe
Tytuł :
A dynamic i-motif with a duplex stem-loop in the long terminal repeat promoter of the HIV-1 proviral genome modulates viral transcription.
Autorzy :
Ruggiero E; Department of Molecular Medicine, University of Padua, 35121 Padua, Italy.
Lago S; Department of Molecular Medicine, University of Padua, 35121 Padua, Italy.
Šket P; Slovenian NMR center, National Institute of Chemistry, Hajdrihova, 19, Ljubljana SI-1000, Slovenia.
Nadai M; Department of Molecular Medicine, University of Padua, 35121 Padua, Italy.
Frasson I; Department of Molecular Medicine, University of Padua, 35121 Padua, Italy.
Plavec J; Slovenian NMR center, National Institute of Chemistry, Hajdrihova, 19, Ljubljana SI-1000, Slovenia.
Richter SN; Department of Molecular Medicine, University of Padua, 35121 Padua, Italy.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2019 Dec 02; Vol. 47 (21), pp. 11057-11068.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV Long Terminal Repeat*
HIV-1*/genetics
HIV-1*/physiology
Promoter Regions, Genetic*
Proviruses*/genetics
Proviruses*/physiology
Heterogeneous-Nuclear Ribonucleoprotein K/*chemistry
RNA, Viral/*chemistry
Binding Sites ; Gene Expression Regulation, Viral ; Transcription, Genetic ; Virus Replication
Czasopismo naukowe
Tytuł :
The dual-target approach in viral HIV-1 viremia testing: An added value to virological monitoring?
Autorzy :
Amendola A; Laboratory of Virology, National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy.
Sberna G; Laboratory of Virology, National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy.
Forbici F; Laboratory of Virology, National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy.
Abbate I; Laboratory of Virology, National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy.
Lorenzini P; Clinical Department, National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy.
Pinnetti C; Clinical Department, National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy.
Antinori A; Clinical Department, National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy.
Capobianchi MR; Laboratory of Virology, National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy.
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Źródło :
PloS one [PLoS One] 2020 Feb 05; Vol. 15 (2), pp. e0228192. Date of Electronic Publication: 2020 Feb 05 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV Infections/*virology
HIV-1/*genetics
Proviruses/*genetics
Viremia/*virology
Adult ; Anti-Retroviral Agents/therapeutic use ; CD4 Lymphocyte Count ; DNA, Viral/blood ; Drug Resistance, Viral ; Female ; Gene Products, pol/genetics ; Genotype ; HIV Infections/drug therapy ; HIV Infections/pathology ; HIV Long Terminal Repeat/genetics ; HIV-1/isolation & purification ; Humans ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/virology ; Logistic Models ; Male ; Middle Aged ; Proviruses/isolation & purification ; RNA, Viral/blood ; Viral Load ; Viremia/pathology
Czasopismo naukowe
Tytuł :
Chromatin maturation of the HIV-1 provirus in primary resting CD4+ T cells.
Autorzy :
Lindqvist B; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Svensson Akusjärvi S; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden.
Sönnerborg A; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden.; Department of Medicine Huddinge, Division of Infectious Diseases, Karolinska Institutet, Huddinge, Sweden.
Dimitriou M; Department of Medicine Huddinge, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Huddinge, Sweden.
Svensson JP; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Jan 30; Vol. 16 (1), pp. e1008264. Date of Electronic Publication: 2020 Jan 30 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD4-Positive T-Lymphocytes/*immunology
Chromatin/*virology
HIV Infections/*virology
HIV-1/*physiology
Proviruses/*physiology
CD4-Positive T-Lymphocytes/virology ; HIV Infections/immunology ; HIV-1/genetics ; Humans ; Proviruses/genetics ; Virus Activation ; Virus Assembly ; Virus Latency
Czasopismo naukowe
Tytuł :
Reduction of peak viremia by an integration-defective SIV proviral DNA vaccine in rhesus macaques.
Autorzy :
Wang C; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China.; The First Hospital and Institute of Immunology, Jilin University, Changchun, Jilin Province, China.
Gao N; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China.
Song Y; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China.
Duan S; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China.
Wang W; Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, China.; Comparative Medicine Center, Peking Union Medical College, Beijing, China.
Cong Z; Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, China.; Comparative Medicine Center, Peking Union Medical College, Beijing, China.
Qin C; Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, China.; Comparative Medicine Center, Peking Union Medical College, Beijing, China.
Jiang C; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China.; Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, Jilin Province, China.
Yu X; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China.; Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, Jilin Province, China.
Gao F; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China.; Department of Medicine, Duke University Medical Center, Durham, North Carolina.
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Źródło :
Microbiology and immunology [Microbiol Immunol] 2020 Jan; Vol. 64 (1), pp. 52-62. Date of Electronic Publication: 2019 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
Proviruses/*immunology
SAIDS Vaccines/*immunology
Vaccines, DNA/*immunology
Viremia/*prevention & control
Animals ; Antibodies, Neutralizing ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; CD4-Positive T-Lymphocytes ; Disease Models, Animal ; Immunity, Humoral ; Immunization ; Macaca mulatta ; Proviruses/genetics ; SAIDS Vaccines/genetics ; SAIDS Vaccines/therapeutic use ; Simian Immunodeficiency Virus/genetics ; Vaccination ; Vaccines, DNA/therapeutic use ; Viral Load
Czasopismo naukowe
Tytuł :
The relative contributions of infectious and mitotic spread to HTLV-1 persistence.
Autorzy :
Laydon DJ; MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom.; Section of Immunology, Wright-Fleming Institute, Imperial College School of Medicine, London, United Kingdom.
Sunkara V; Department of Mathematics and Computer Science, Freie Universität, Arnimallee, Berlin, Germany.
Boelen L; Section of Immunology, Wright-Fleming Institute, Imperial College School of Medicine, London, United Kingdom.
Bangham CRM; Section of Immunology, Wright-Fleming Institute, Imperial College School of Medicine, London, United Kingdom.
Asquith B; Section of Immunology, Wright-Fleming Institute, Imperial College School of Medicine, London, United Kingdom.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2020 Sep 17; Vol. 16 (9), pp. e1007470. Date of Electronic Publication: 2020 Sep 17 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HTLV-I Infections*/physiopathology
HTLV-I Infections*/virology
Host-Pathogen Interactions*/genetics
Host-Pathogen Interactions*/physiology
Human T-lymphotropic virus 1*/classification
Human T-lymphotropic virus 1*/genetics
Human T-lymphotropic virus 1*/pathogenicity
CD4-Positive T-Lymphocytes/virology ; Humans ; Mitosis/genetics ; Mitosis/physiology ; Models, Biological ; Proviruses/genetics ; Proviruses/pathogenicity ; Viral Load/genetics ; Virus Integration/genetics
Czasopismo naukowe
Tytuł :
Development and evaluation of human T-cell leukemia virus-1 and -2 multiplex quantitative PCR.
Autorzy :
Kuramitsu M; Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo, Japan.
Okuma K; Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo, Japan.
Tezuka K; Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo, Japan.
Nakamura H; Department of Quality, Japanese Red Cross Kyushu Block Blood Center, Fukuoka, Japan.
Sagara Y; Department of Quality, Japanese Red Cross Kyushu Block Blood Center, Fukuoka, Japan.
Kurane I; Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan.
Hamaguchi I; Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo, Japan.
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Źródło :
Microbiology and immunology [Microbiol Immunol] 2019 Nov; Vol. 63 (11), pp. 458-464. Date of Electronic Publication: 2019 Sep 11.
Typ publikacji :
Evaluation Study; Journal Article
MeSH Terms :
HTLV-I Infections/*diagnosis
HTLV-II Infections/*diagnosis
Human T-lymphotropic virus 1/*isolation & purification
Human T-lymphotropic virus 2/*isolation & purification
Multiplex Polymerase Chain Reaction/*methods
Proviruses/*isolation & purification
Real-Time Polymerase Chain Reaction/*methods
HTLV-I Infections/virology ; HTLV-II Infections/virology ; Human T-lymphotropic virus 1/genetics ; Human T-lymphotropic virus 2/genetics ; Humans ; Japan ; Proviruses/genetics ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
The free energy landscape of retroviral integration.
Autorzy :
Vanderlinden W; Department of Physics, Nanosystems Initiative Munich, Center for NanoScience, LMU Munich, Amalienstrasse 54, 80799, Munich, Germany. .; KU Leuven, Division of Molecular Imaging and Photonics, Celestijnenlaan 200F, 3001, Leuven, Belgium. .
Brouns T; KU Leuven, Division of Molecular Imaging and Photonics, Celestijnenlaan 200F, 3001, Leuven, Belgium.; KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Kapucijnenvoer 33 blok i - box 7001, 3000, Leuven, Flanders, Belgium.
Walker PU; Department of Physics, Nanosystems Initiative Munich, Center for NanoScience, LMU Munich, Amalienstrasse 54, 80799, Munich, Germany.
Kolbeck PJ; Department of Physics, Nanosystems Initiative Munich, Center for NanoScience, LMU Munich, Amalienstrasse 54, 80799, Munich, Germany.
Milles LF; Department of Physics, Nanosystems Initiative Munich, Center for NanoScience, LMU Munich, Amalienstrasse 54, 80799, Munich, Germany.
Ott W; Department of Physics, Nanosystems Initiative Munich, Center for NanoScience, LMU Munich, Amalienstrasse 54, 80799, Munich, Germany.
Nickels PC; Department of Physics, Nanosystems Initiative Munich, Center for NanoScience, LMU Munich, Amalienstrasse 54, 80799, Munich, Germany.
Debyser Z; KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Kapucijnenvoer 33 blok i - box 7001, 3000, Leuven, Flanders, Belgium.
Lipfert J; Department of Physics, Nanosystems Initiative Munich, Center for NanoScience, LMU Munich, Amalienstrasse 54, 80799, Munich, Germany. .
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Źródło :
Nature communications [Nat Commun] 2019 Oct 18; Vol. 10 (1), pp. 4738. Date of Electronic Publication: 2019 Oct 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Integrases/*chemistry
Proviruses/*genetics
Retroviridae/*genetics
Spumavirus/*genetics
Virus Integration/*genetics
Crystallography, X-Ray ; DNA, Viral/chemistry ; DNA, Viral/genetics ; DNA, Viral/metabolism ; Host-Pathogen Interactions/genetics ; Humans ; Integrases/genetics ; Integrases/metabolism ; Macromolecular Substances ; Microscopy, Atomic Force ; Models, Molecular ; Nucleic Acid Conformation ; Nucleoproteins/chemistry ; Nucleoproteins/genetics ; Nucleoproteins/metabolism ; Protein Multimerization ; Proviruses/enzymology ; Retroviridae/enzymology ; Spumavirus/enzymology
Czasopismo naukowe
Tytuł :
Targeting the proviral host kinase, FAK, limits influenza a virus pathogenesis and NFkB-regulated pro-inflammatory responses.
Autorzy :
Bergmann S; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Elbahesh H; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, 38163, USA. Electronic address: .
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Źródło :
Virology [Virology] 2019 Aug; Vol. 534, pp. 54-63. Date of Electronic Publication: 2019 Jun 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Focal Adhesion Protein-Tyrosine Kinases/*immunology
Influenza A Virus, H1N1 Subtype/*pathogenicity
Influenza, Human/*enzymology
NF-kappa B/*immunology
Proviruses/*pathogenicity
Animals ; Female ; Focal Adhesion Protein-Tyrosine Kinases/genetics ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H1N1 Subtype/physiology ; Influenza, Human/genetics ; Influenza, Human/immunology ; Influenza, Human/virology ; Mice ; Mice, Inbred DBA ; NF-kappa B/genetics ; Promoter Regions, Genetic ; Proviruses/genetics ; Proviruses/physiology ; Viral Load ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/metabolism ; Virulence ; Virus Replication
Czasopismo naukowe
Tytuł :
Inhibition of ABL1 tyrosine kinase reduces HTLV-1 proviral loads in peripheral blood mononuclear cells from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis.
Autorzy :
Kodama D; Division of Neuroimmunology, Joint Research Center for Human Retrovirus Infection, Kagoshima University, Kagoshima City, Kagoshima, JAPAN.
Tanaka M; Division of Neuroimmunology, Joint Research Center for Human Retrovirus Infection, Kagoshima University, Kagoshima City, Kagoshima, JAPAN.
Matsuzaki T; Division of Neuroimmunology, Joint Research Center for Human Retrovirus Infection, Kagoshima University, Kagoshima City, Kagoshima, JAPAN.; Medical Corporation Sanshukai Ohkatsu Hospital, Kagoshima City, Kagoshima, JAPAN.
Izumo K; Division of Neuroimmunology, Joint Research Center for Human Retrovirus Infection, Kagoshima University, Kagoshima City, Kagoshima, JAPAN.; Department of Hygiene and Health Promotion Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima City, Kagoshima, JAPAN.
Nakano N; Department of Hematology, Imamura General Hospital, Kagoshima City, Kagoshima, JAPAN.
Matsuura E; Department of Neurology and Geriatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima City, Kagoshima, JAPAN.
Saito M; Department of Microbiology, Kawasaki Medical School, Kurashiki City, Okayama, JAPAN.
Nagai M; Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, Toon City, Ehime, JAPAN.
Horiuchi M; Department of Hygiene and Health Promotion Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima City, Kagoshima, JAPAN.
Utsunomiya A; Department of Hematology, Imamura General Hospital, Kagoshima City, Kagoshima, JAPAN.
Takashima H; Department of Neurology and Geriatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima City, Kagoshima, JAPAN.
Kubota R; Division of Neuroimmunology, Joint Research Center for Human Retrovirus Infection, Kagoshima University, Kagoshima City, Kagoshima, JAPAN.
Izumo S; Division of Neuroimmunology, Joint Research Center for Human Retrovirus Infection, Kagoshima University, Kagoshima City, Kagoshima, JAPAN.
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Źródło :
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Jul 15; Vol. 14 (7), pp. e0008361. Date of Electronic Publication: 2020 Jul 15 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HTLV-I Infections/*complications
Human T-lymphotropic virus 1/*physiology
Leukocytes, Mononuclear/*virology
Paraparesis, Tropical Spastic/*enzymology
Spinal Cord Diseases/*enzymology
Adult ; Aged ; DNA, Viral/genetics ; Female ; HTLV-I Infections/virology ; Humans ; Male ; Middle Aged ; Paraparesis, Tropical Spastic/drug therapy ; Paraparesis, Tropical Spastic/etiology ; Paraparesis, Tropical Spastic/genetics ; Protein Kinase Inhibitors/administration & dosage ; Proto-Oncogene Proteins c-abl/antagonists & inhibitors ; Proto-Oncogene Proteins c-abl/genetics ; Proto-Oncogene Proteins c-abl/metabolism ; Proviruses/genetics ; Proviruses/physiology ; Retrospective Studies ; Spinal Cord Diseases/drug therapy ; Spinal Cord Diseases/etiology ; Spinal Cord Diseases/genetics ; Viral Load
Czasopismo naukowe
Tytuł :
A Protein Antagonist of Activation-Induced Cytidine Deaminase Encoded by a Complex Mouse Retrovirus.
Autorzy :
Singh GB; Dept. of Molecular Biosciences, LaMontagne Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA.
Byun H; Dept. of Molecular Biosciences, LaMontagne Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA.
Ali AF; Dept. of Molecular Biosciences, LaMontagne Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA.
Medina F; Dept. of Molecular Biosciences, LaMontagne Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA.
Wylie D; Computational Biology and Bioinformatics and Center for Biomedical Research Support, The University of Texas at Austin, Austin, Texas, USA.
Shivram H; Dept. of Molecular Biosciences, LaMontagne Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA.
Nash AK; Dept. of Molecular Biosciences, LaMontagne Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA.
Lozano MM; Dept. of Molecular Biosciences, LaMontagne Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA.
Dudley JP; Dept. of Molecular Biosciences, LaMontagne Center for Infectious Disease, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA .
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Źródło :
MBio [mBio] 2019 Aug 13; Vol. 10 (4). Date of Electronic Publication: 2019 Aug 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cytidine Deaminase/*antagonists & inhibitors
Mammary Tumor Virus, Mouse/*genetics
Proviruses/*genetics
Viral Regulatory and Accessory Proteins/*genetics
Animals ; Cytidine Deaminase/genetics ; Cytidine Deaminase/metabolism ; Female ; Immunity, Innate ; Male ; Mammary Neoplasms, Experimental/immunology ; Mammary Neoplasms, Experimental/virology ; Mammary Tumor Virus, Mouse/physiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Mutation ; Proviruses/physiology ; Retroviridae Infections/immunology ; Retroviridae Infections/virology ; Tumor Virus Infections/immunology ; Tumor Virus Infections/virology ; Viral Load/genetics ; Viral Regulatory and Accessory Proteins/metabolism ; Virus Replication
Czasopismo naukowe
Tytuł :
Transcriptional Circuit Fragility Influences HIV Proviral Fate.
Autorzy :
Morton EL; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Forst CV; Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Zheng Y; Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
DePaula-Silva AB; Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Ramirez NP; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Planelles V; Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
D'Orso I; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2019 Apr 02; Vol. 27 (1), pp. 154-171.e9.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Proviruses*/genetics
Proviruses*/physiology
Gene Regulatory Networks/*physiology
HIV Infections/*virology
HIV-1/*genetics
Virus Activation/*genetics
Virus Latency/*genetics
Cells, Cultured ; Gene Expression Regulation, Viral ; Genome, Viral ; Genomic Instability/physiology ; HEK293 Cells ; HIV Infections/genetics ; HIV-1/physiology ; Humans ; Jurkat Cells ; Transcription, Genetic ; Virus Replication/genetics
Czasopismo naukowe
Tytuł :
The chromatin landscape at the HIV-1 provirus integration site determines viral expression.
Autorzy :
Vansant G; Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Flanders, Belgium.
Chen HC; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Catalunya, Spain.
Zorita E; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Catalunya, Spain.
Trejbalová K; Institute of Molecular Genetics, Czech Academy of Sciences, Videnska, Prague, Czech Republic.
Miklík D; Institute of Molecular Genetics, Czech Academy of Sciences, Videnska, Prague, Czech Republic.
Filion G; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Catalunya, Spain.; University Pompeu Fabra, Barcelona, Catalunya, Spain.
Debyser Z; Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Flanders, Belgium.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Aug 20; Vol. 48 (14), pp. 7801-7817.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Viral*/drug effects
Gene Silencing*
Virus Integration*/drug effects
HIV-1/*genetics
Proviruses/*genetics
Cell Line ; Chromatin/metabolism ; HIV Integrase Inhibitors/pharmacology ; HIV-1/drug effects ; HIV-1/metabolism ; Histones/metabolism ; Humans ; Intercellular Signaling Peptides and Proteins ; RNA, Viral/metabolism
Czasopismo naukowe
Tytuł :
Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells.
Autorzy :
Chen TC; Department of Microbiology & Immunology, Stanford University SOM, Stanford, California, United States of America.; Chan Zuckerberg Biohub, San Francisco, California, United States of America.
Tallo-Parra M; Molecular Virology Group, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
Cao QM; Department of Microbiology & Immunology, Stanford University SOM, Stanford, California, United States of America.; Chan Zuckerberg Biohub, San Francisco, California, United States of America.
Kadener S; Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America.
Böttcher R; Molecular Virology Group, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
Pérez-Vilaró G; Molecular Virology Group, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
Boonchuen P; Department of Biochemistry, Chulalongkorn University, Bangkog, Thailand.
Somboonwiwat K; Department of Biochemistry, Chulalongkorn University, Bangkog, Thailand.
Díez J; Molecular Virology Group, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
Sarnow P; Department of Microbiology & Immunology, Stanford University SOM, Stanford, California, United States of America.; Chan Zuckerberg Biohub, San Francisco, California, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Aug 07; Vol. 16 (8), pp. e1008346. Date of Electronic Publication: 2020 Aug 07 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Replication*
Carcinoma, Hepatocellular/*virology
Hepacivirus/*genetics
Hepatitis C/*complications
Liver Neoplasms/*virology
Proviruses/*genetics
RNA, Circular/*genetics
RNA, Viral/*genetics
Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; Eukaryotic Initiation Factor-4A/genetics ; Eukaryotic Initiation Factor-4A/metabolism ; Gene Expression Profiling ; Hepatitis C/virology ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Nonsense Mediated mRNA Decay ; Viral Proteins/genetics ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA.
Autorzy :
Simonetti FR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
White JA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Tumiotto C; Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA 15260.
Ritter KD; AccelevirDx, Baltimore, MD 21205.
Cai M; AccelevirDx, Baltimore, MD 21205.
Gandhi RT; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114.
Deeks SG; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, CA 94118.
Howell BJ; Merck & Co., Kenilworth, NJ 07033.
Montaner LJ; The Wistar Institute, Philadelphia, PA 19104.
Blankson JN; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Martin A; AccelevirDx, Baltimore, MD 21205.
Laird GM; AccelevirDx, Baltimore, MD 21205.
Siliciano RF; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; .; HHMI, Baltimore, MD 21205.
Mellors JW; Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA 15260.
Siliciano JD; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 04; Vol. 117 (31), pp. 18692-18700. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV Infections*/blood
HIV Infections*/epidemiology
HIV Infections*/virology
DNA, Viral/*blood
Proviruses/*genetics
Virus Latency/*genetics
Adult ; Female ; Humans ; Male ; Middle Aged ; Polymerase Chain Reaction/methods
Czasopismo naukowe
Tytuł :
Deficient uracil base excision repair leads to persistent dUMP in HIV proviruses during infection of monocytes and macrophages.
Autorzy :
Meshesha M; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Esadze A; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Cui J; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Churgulia N; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Sahu SK; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Stivers JT; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Jul 14; Vol. 15 (7), pp. e0235012. Date of Electronic Publication: 2020 Jul 14 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
HIV Infections/*genetics
Macrophages/*virology
Monocytes/*virology
Proviruses/*genetics
Uracil/*metabolism
DNA, Viral/genetics ; Deoxyuracil Nucleotides/deficiency ; Deoxyuracil Nucleotides/metabolism ; HIV-1/genetics ; Humans ; Uracil-DNA Glycosidase/metabolism
Czasopismo naukowe
Tytuł :
Bovine leukemia virus proviral load is more strongly associated with bovine major histocompatibility complex class II DRB3 polymorphism than with DQA1 polymorphism in Holstein cow in Japan.
Autorzy :
Takeshima SN; Viral Infectious Diseases Unit, RIKEN, Wako, Saitama, 351-0198, Japan.; Photonics Control Technology Team, RIKEN Center for Advanced Photonics, Wako, Saitama, 3510198, Japan.; Department of Food and Nutrition, Jumonji University, Niiza, Saitama, 352-8510, Japan.
Ohno A; Viral Infectious Diseases Unit, RIKEN, Wako, Saitama, 351-0198, Japan.
Aida Y; Viral Infectious Diseases Unit, RIKEN, Wako, Saitama, 351-0198, Japan. .; Nakamura Laboratory, Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, Wako, Saitama, 351-0198, Japan. .
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Źródło :
Retrovirology [Retrovirology] 2019 May 16; Vol. 16 (1), pp. 14. Date of Electronic Publication: 2019 May 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Leukemia Virus, Bovine*
Polymorphism, Genetic*
Proviruses*
Viral Load*
Histocompatibility Antigens Class II/*genetics
Alleles ; Animals ; Cattle ; Disease Resistance/genetics ; Female ; Genetic Predisposition to Disease ; Haplotypes ; Japan ; Phenotype
Czasopismo naukowe

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