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Tytuł :
Pulmonary Stretch and Lung Mechanotransduction: Implications for Progression in the Fibrotic Lung.
Autorzy :
Marchioni A; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41125 Modena, Italy.; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41125 Modena, Italy.
Tonelli R; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41125 Modena, Italy.; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41125 Modena, Italy.; Clinical and Experimental Medicine PhD Program, University of Modena Reggio Emilia, 41125 Modena, Italy.
Cerri S; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41125 Modena, Italy.; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41125 Modena, Italy.
Castaniere I; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41125 Modena, Italy.; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41125 Modena, Italy.
Andrisani D; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41125 Modena, Italy.; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41125 Modena, Italy.; Clinical and Experimental Medicine PhD Program, University of Modena Reggio Emilia, 41125 Modena, Italy.
Gozzi F; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41125 Modena, Italy.; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41125 Modena, Italy.; Clinical and Experimental Medicine PhD Program, University of Modena Reggio Emilia, 41125 Modena, Italy.
Bruzzi G; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41125 Modena, Italy.; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41125 Modena, Italy.
Manicardi L; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41125 Modena, Italy.; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41125 Modena, Italy.
Moretti A; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41125 Modena, Italy.; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41125 Modena, Italy.
Demurtas J; Primary Care Department USL Toscana Sud Est-Grosseto, 58100 Grosseto, Italy.
Baroncini S; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41125 Modena, Italy.
Andreani A; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41125 Modena, Italy.
Cappiello GF; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41125 Modena, Italy.
Busani S; University Hospital of Modena, Anesthesiology Unit, University of Modena Reggio Emilia, 41124 Modena, Italy.
Fantini R; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41125 Modena, Italy.
Tabbì L; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41125 Modena, Italy.
Samarelli AV; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41125 Modena, Italy.; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41125 Modena, Italy.
Clini E; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41125 Modena, Italy.; University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41125 Modena, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 16; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Elasticity*
Mechanotransduction, Cellular*
Lung/*metabolism
Lung/*pathology
Pulmonary Fibrosis/*metabolism
Pulmonary Fibrosis/*pathology
Algorithms ; Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/pathology ; Animals ; Disease Progression ; Disease Susceptibility ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Humans ; Idiopathic Pulmonary Fibrosis/etiology ; Idiopathic Pulmonary Fibrosis/metabolism ; Idiopathic Pulmonary Fibrosis/pathology ; Mechanical Phenomena ; Models, Biological ; Pulmonary Fibrosis/etiology
Czasopismo naukowe
Tytuł :
Citrus Alkaline Extracts Inhibit Senescence of A549 Cells to Alleviate Pulmonary Fibrosis via the β-Catenin/P53 Pathway.
Autorzy :
Han D; Department of Respiratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China (mainland).
Xu Y; Department of Respiratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China (mainland).
Peng WP; Department of Respiratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China (mainland).
Feng F; Department of Respiratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China (mainland).; Department of Respiratory Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, China (mainland).
Wang Z; Department of Respiratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China (mainland).
Gu C; Department of Respiratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China (mainland).
Zhou X; Department of Respiratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China (mainland).; Department of Respiratory Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, China (mainland).
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Źródło :
Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2021 Mar 12; Vol. 27, pp. e928547. Date of Electronic Publication: 2021 Mar 12.
Typ publikacji :
Journal Article
MeSH Terms :
Alveolar Epithelial Cells/*metabolism
Citrus/*metabolism
Idiopathic Pulmonary Fibrosis/*metabolism
A549 Cells ; Aging/drug effects ; Aging/physiology ; Alveolar Epithelial Cells/drug effects ; Cellular Senescence/drug effects ; Cellular Senescence/physiology ; China ; Doxorubicin/adverse effects ; Doxorubicin/pharmacology ; Fibroblasts/metabolism ; Humans ; Idiopathic Pulmonary Fibrosis/drug therapy ; Lung/metabolism ; Plant Extracts/pharmacology ; Pulmonary Fibrosis/metabolism ; Tumor Suppressor Protein p53/metabolism ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
PPARγ mediates the anti-pulmonary fibrosis effect of icaritin.
Autorzy :
Hua Q; Xiangya Nursing School, Central South University, Changsha, Hunan, China.
Huang X; Xiangya Nursing School, Central South University, Changsha, Hunan, China.
Xie W; Xiangya Nursing School, Central South University, Changsha, Hunan, China.
Zhao F; College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, China.
Cheng H; Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Luo Z; Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Han J; Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Wang Z; Xiangya Nursing School, Central South University, Changsha, Hunan, China.
Zeng Q; Xiangya Nursing School, Central South University, Changsha, Hunan, China.
Lin M; Xiangya Nursing School, Central South University, Changsha, Hunan, China.
Zhou T; Xiangya Nursing School, Central South University, Changsha, Hunan, China.
Zhang J; Xiangya Nursing School, Central South University, Changsha, Hunan, China.
Gu C; Xiangya Nursing School, Central South University, Changsha, Hunan, China. Electronic address: .
Liu W; Xiangya Nursing School, Central South University, Changsha, Hunan, China. Electronic address: .
Tang S; Xiangya Nursing School, Central South University, Changsha, Hunan, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Oct 10; Vol. 350, pp. 81-90. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article
MeSH Terms :
Flavonoids/*metabolism
Flavonoids/*therapeutic use
PPAR gamma/*genetics
PPAR gamma/*metabolism
Pulmonary Fibrosis/*drug therapy
Pulmonary Fibrosis/*genetics
Pulmonary Fibrosis/*metabolism
Animals ; Bleomycin/pharmacology ; Cell Differentiation/drug effects ; Epimedium/chemistry ; Female ; Fibroblasts/drug effects ; Humans ; Medicine, Chinese Traditional ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Pulmonary Fibrosis/chemically induced
Czasopismo naukowe
Tytuł :
Triiodothyronine ameliorates silica-induced pulmonary inflammation and fibrosis in mice.
Autorzy :
Yang M; Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
Wang D; Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Gan S; Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Wang B; Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Yu L; Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Xie Y; Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Fan L; Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Ma J; Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Chen W; Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: .
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Źródło :
The Science of the total environment [Sci Total Environ] 2021 Oct 10; Vol. 790, pp. 148041. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article
MeSH Terms :
Pneumonia*/chemically induced
Pneumonia*/prevention & control
Pulmonary Fibrosis*/chemically induced
Pulmonary Fibrosis*/pathology
Pulmonary Fibrosis*/prevention & control
Animals ; Fibrosis ; Inflammation/chemically induced ; Inflammation/pathology ; Lung/pathology ; Mice ; Mice, Inbred C57BL ; Silicon Dioxide/toxicity ; Triiodothyronine
Czasopismo naukowe
Tytuł :
Alpha-lipoic acid attenuates silica-induced pulmonary fibrosis by improving mitochondrial function via AMPK/PGC1α pathway activation in C57BL/6J mice.
Autorzy :
Chang M; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Xu G; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Xiong C; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Yang X; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Yan S; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Tao Y; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Li H; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Li Y; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Yao S; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China.
Zhao Y; School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Oct 10; Vol. 350, pp. 121-132. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
AMP-Activated Protein Kinases/*metabolism
Mitochondria/*metabolism
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/*metabolism
Pulmonary Fibrosis/*chemically induced
Pulmonary Fibrosis/*drug therapy
Silicon Dioxide/*adverse effects
Silicosis/*drug therapy
Thioctic Acid/*therapeutic use
AMP-Activated Protein Kinases/drug effects ; Animals ; Antioxidants/metabolism ; Antioxidants/therapeutic use ; Humans ; Male ; Metabolic Networks and Pathways ; Mice ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Models, Animal ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/drug effects ; Pulmonary Fibrosis/metabolism ; Silicosis/metabolism ; Silicosis/physiopathology ; Thioctic Acid/metabolism
Czasopismo naukowe
Tytuł :
The interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis.
Autorzy :
Bolourani S; Center for Immunology and Inflammation, Feinstein Institutes for Medical Research, 350 Community Dr, Manhasset, NY, 11030, USA.; Elmezzi Graduate School of Molecular Medicine, Manhasset, NY, USA.; Department of Surgery, Donald and Barbara Zucker School of Medicine At Hofstra/Northwell, Manhasset, NY, USA.
Brenner M; Center for Immunology and Inflammation, Feinstein Institutes for Medical Research, 350 Community Dr, Manhasset, NY, 11030, USA. .; Elmezzi Graduate School of Molecular Medicine, Manhasset, NY, USA. .; Department of Molecular Medicine, Donald and Barbara Zucker School of Medicine At Hofstra/Northwell, Manhasset, NY, USA. .
Wang P; Center for Immunology and Inflammation, Feinstein Institutes for Medical Research, 350 Community Dr, Manhasset, NY, 11030, USA. .; Elmezzi Graduate School of Molecular Medicine, Manhasset, NY, USA. .; Department of Surgery, Donald and Barbara Zucker School of Medicine At Hofstra/Northwell, Manhasset, NY, USA. .; Department of Molecular Medicine, Donald and Barbara Zucker School of Medicine At Hofstra/Northwell, Manhasset, NY, USA. .
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Źródło :
Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 2021 Oct; Vol. 99 (10), pp. 1373-1384. Date of Electronic Publication: 2021 Jul 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Alarmins/*metabolism
Cytokines/*metabolism
Idiopathic Pulmonary Fibrosis/*metabolism
Inflammation/*metabolism
Toll-Like Receptor 4/*metabolism
Animals ; Humans ; Idiopathic Pulmonary Fibrosis/complications ; Idiopathic Pulmonary Fibrosis/therapy ; Inflammation/complications ; Models, Biological
Czasopismo naukowe
Tytuł :
Understanding idiopathic pulmonary fibrosis - Clinical features, molecular mechanism and therapies.
Autorzy :
Suri GS; California Baptist University, United States.
Kaur G; California Baptist University, United States.
Jha CK; Department of Human Genetics, Punjabi University, India.
Tiwari M; University of Florida, United States. Electronic address: .
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Źródło :
Experimental gerontology [Exp Gerontol] 2021 Oct 01; Vol. 153, pp. 111473. Date of Electronic Publication: 2021 Jul 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Idiopathic Pulmonary Fibrosis*/diagnosis
Idiopathic Pulmonary Fibrosis*/drug therapy
Idiopathic Pulmonary Fibrosis*/genetics
Epithelial Cells ; Fibroblasts/pathology ; Fibrosis ; Humans ; Prognosis
Czasopismo naukowe
Tytuł :
Uniportal video-assisted thoracic surgery and perioperative pirfenidone for lung cancer and idiopathic pulmonary fibrosis: a case report.
Autorzy :
Saiki A; Department of General Thoracic Surgery, Social Welfare Organization Saiseikai Imperial Gift Foundation, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.; Department of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
Mizobuchi T; Department of General Thoracic Surgery, Social Welfare Organization Saiseikai Imperial Gift Foundation, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
Nagato K; Department of General Thoracic Surgery, Social Welfare Organization Saiseikai Imperial Gift Foundation, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
Ishibashi F; Department of General Thoracic Surgery, Social Welfare Organization Saiseikai Imperial Gift Foundation, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
Tsuyusaki J; Department of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
Sugano I; Department of Pathology, Social Welfare Organization Saiseikai Imperial Gift Foundation, Chibaken Saiseikai Narashino Hospital, Chiba, Japan.
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Źródło :
The Journal of international medical research [J Int Med Res] 2021 Sep; Vol. 49 (9), pp. 3000605211016998.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Idiopathic Pulmonary Fibrosis*/diagnostic imaging
Idiopathic Pulmonary Fibrosis*/drug therapy
Idiopathic Pulmonary Fibrosis*/surgery
Lung Neoplasms*/diagnostic imaging
Lung Neoplasms*/drug therapy
Lung Neoplasms*/surgery
Aged ; Female ; Humans ; Neoplasm Recurrence, Local ; Pyridones ; Thoracic Surgery, Video-Assisted
Czasopismo naukowe
Tytuł :
Silibinin alleviates silica-induced pulmonary fibrosis: Potential role in modulating inflammation and epithelial-mesenchymal transition.
Autorzy :
Ali SA; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research-(NIPER), Hyderabad, India.; Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research-(NIPER), Hyderabad, India.
Saifi MA; Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research-(NIPER), Hyderabad, India.
Godugu C; Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research-(NIPER), Hyderabad, India.
Talla V; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research-(NIPER), Hyderabad, India.
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Źródło :
Phytotherapy research : PTR [Phytother Res] 2021 Sep; Vol. 35 (9), pp. 5290-5304. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelial-Mesenchymal Transition*/drug effects
Inflammation*/drug therapy
Pulmonary Fibrosis*/chemically induced
Pulmonary Fibrosis*/drug therapy
Silybin/*pharmacology
Animals ; Bleomycin ; Mice ; Silicon Dioxide
Czasopismo naukowe
Tytuł :
Cross-species integration of single-cell RNA-seq resolved alveolar-epithelial transitional states in idiopathic pulmonary fibrosis.
Autorzy :
Huang KY; Program in Cardiovascular and Metabolic Disorders (CVMD) and Center for Computational Biology (CCB), Duke-NUS Medical School, Singapore, Republic of Singapore.
Petretto E; Program in Cardiovascular and Metabolic Disorders (CVMD) and Center for Computational Biology (CCB), Duke-NUS Medical School, Singapore, Republic of Singapore.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2021 Sep 01; Vol. 321 (3), pp. L491-L506. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Idiopathic Pulmonary Fibrosis*/genetics
Idiopathic Pulmonary Fibrosis*/metabolism
Idiopathic Pulmonary Fibrosis*/pathology
RNA-Seq*
Single-Cell Analysis*
Alveolar Epithelial Cells/*metabolism
Respiratory Mucosa/*metabolism
Alveolar Epithelial Cells/pathology ; Animals ; Disease Models, Animal ; Humans ; Mice ; Mice, Knockout ; Respiratory Mucosa/pathology ; Species Specificity
Czasopismo naukowe
Tytuł :
CircRNA_0026344 via exosomal miR-21 regulation of Smad7 is involved in aberrant cross-talk of epithelium-fibroblasts during cigarette smoke-induced pulmonary fibrosis.
Autorzy :
Bai J; School of Public Health, Southwest Medical University, Luzhou, 646000, Sichuan, People's Republic of China.
Deng J; Department of Clinical Laboratory, 404 Hospital of Mianyang, Mianyang, 621000, Sichuan, People's Republic of China.
Han Z; School of Public Health, Southwest Medical University, Luzhou, 646000, Sichuan, People's Republic of China.
Cui Y; School of Public Health, Southwest Medical University, Luzhou, 646000, Sichuan, People's Republic of China.
He R; School of Public Health, Southwest Medical University, Luzhou, 646000, Sichuan, People's Republic of China.
Gu Y; Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, 646000, Sichuan, People's Republic of China. Electronic address: .
Zhang Q; School of Public Health, Southwest Medical University, Luzhou, 646000, Sichuan, People's Republic of China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Sep 01; Vol. 347, pp. 58-66. Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Communication*
Epithelial Cells/*metabolism
Exosomes/*metabolism
Fibroblasts/*metabolism
Lung/*metabolism
Pulmonary Fibrosis/*metabolism
RNA, Circular/*metabolism
Smad7 Protein/*metabolism
Animals ; Cell Line ; Disease Models, Animal ; Epithelial Cells/pathology ; Exosomes/genetics ; Exosomes/pathology ; Fibroblasts/pathology ; Gene Expression Regulation ; Humans ; Lung/pathology ; Male ; Mice, Inbred BALB C ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Pulmonary Fibrosis/etiology ; Pulmonary Fibrosis/genetics ; Pulmonary Fibrosis/pathology ; RNA, Circular/genetics ; Signal Transduction ; Smad7 Protein/genetics ; Smoke ; Tobacco Products ; Transforming Growth Factor beta1/metabolism
Czasopismo naukowe
Tytuł :
Diagnosis and Management of Idiopathic Pulmonary Fibrosis.
Autorzy :
Munchel JK; Division of Pulmonary, Critical Care and Sleep Medicine; Rhode Island Hospital and Alpert Medical School of Brown University; Providence, RI.
Shea BS; Division of Pulmonary, Critical Care and Sleep Medicine; Rhode Island Hospital and Alpert Medical School of Brown University; Providence, RI.
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Źródło :
Rhode Island medical journal (2013) [R I Med J (2013)] 2021 Sep 01; Vol. 104 (7), pp. 26-29. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Idiopathic Pulmonary Fibrosis*/diagnostic imaging
Idiopathic Pulmonary Fibrosis*/therapy
Lung Diseases, Interstitial*/diagnosis
Biopsy ; Diagnosis, Differential ; Humans ; Lung/diagnostic imaging ; Tomography, X-Ray Computed
Czasopismo naukowe
Tytuł :
The protective potential of alpha lipoic acid on amiodarone-induced pulmonary fibrosis and hepatic injury in rats.
Autorzy :
Ibrahim Fouad G; Department of Therapeutic Chemistry, National Research Centre, 33 El-Bohouth St., Dokki, Cairo, 12622, Egypt. .
R Mousa M; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Sep; Vol. 476 (9), pp. 3433-3448. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Journal Article
MeSH Terms :
Amiodarone/*toxicity
Antioxidants/*pharmacology
Chemical and Drug Induced Liver Injury/*prevention & control
Protective Agents/*pharmacology
Pulmonary Fibrosis/*prevention & control
Thioctic Acid/*pharmacology
Alanine Transaminase/metabolism ; Animals ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Cytokines/metabolism ; Glutathione/metabolism ; Inflammation Mediators/metabolism ; Male ; Malondialdehyde/metabolism ; Oxidative Stress ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/metabolism ; Pulmonary Fibrosis/pathology ; Rats ; Rats, Wistar ; Vasodilator Agents/toxicity
Czasopismo naukowe
Tytuł :
Spatially Resolved Identification of Transglutaminase Substrates by Proteomics in Pulmonary Fibrosis.
Autorzy :
Takeuchi T; Cellular Biochemistry Laboratory, Graduate School of Pharmaceutical Sciences, and.
Tatsukawa H; Cellular Biochemistry Laboratory, Graduate School of Pharmaceutical Sciences, and.
Shinoda Y; Cellular Biochemistry Laboratory, Graduate School of Pharmaceutical Sciences, and.
Kuwata K; Institute of Transformative Bio-Molecules, Nagoya University, Tokai National Higher Education and Research System, Furo-cho, Chikusa, Nagoya, Japan; and.
Nishiga M; Teijin Institute for Bio-Medical Research, Teijin Pharma Limited, Hino, Tokyo, Japan.
Takahashi H; Teijin Institute for Bio-Medical Research, Teijin Pharma Limited, Hino, Tokyo, Japan.
Hase N; Teijin Institute for Bio-Medical Research, Teijin Pharma Limited, Hino, Tokyo, Japan.
Hitomi K; Cellular Biochemistry Laboratory, Graduate School of Pharmaceutical Sciences, and.
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Źródło :
American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2021 Sep; Vol. 65 (3), pp. 319-330.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteomics*
Signal Transduction*
GTP-Binding Proteins/*metabolism
Lung/*enzymology
Pulmonary Fibrosis/*epidemiology
Transglutaminases/*metabolism
Animals ; Lung/pathology ; Mice ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/pathology
Czasopismo naukowe
Tytuł :
Dysbalance of ACE2 levels - a possible cause for severe COVID-19 outcome in COPD.
Autorzy :
Fließer E; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria.
Birnhuber A; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria.
Marsh LM; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria.
Gschwandtner E; Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.
Klepetko W; Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.
Olschewski H; Division of Pulmonology, Medical University of Graz, Graz, Austria.
Kwapiszewska G; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria.; Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
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Źródło :
The journal of pathology. Clinical research [J Pathol Clin Res] 2021 Sep; Vol. 7 (5), pp. 446-458. Date of Electronic Publication: 2021 May 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2/*metabolism
COVID-19/*pathology
Familial Primary Pulmonary Hypertension/*pathology
Idiopathic Pulmonary Fibrosis/*pathology
Pulmonary Disease, Chronic Obstructive/*pathology
SARS-CoV-2/*physiology
Serine Endopeptidases/*metabolism
Adult ; Aged ; Angiotensin-Converting Enzyme 2/genetics ; Basigin/genetics ; Basigin/metabolism ; COVID-19/metabolism ; COVID-19/virology ; Disease Susceptibility ; Familial Primary Pulmonary Hypertension/enzymology ; Familial Primary Pulmonary Hypertension/virology ; Female ; Furin/genetics ; Furin/metabolism ; Gene Expression Regulation ; Humans ; Idiopathic Pulmonary Fibrosis/metabolism ; Idiopathic Pulmonary Fibrosis/virology ; Lung/metabolism ; Lung/pathology ; Lung/virology ; Male ; Middle Aged ; Pulmonary Disease, Chronic Obstructive/metabolism ; Pulmonary Disease, Chronic Obstructive/virology ; Risk Factors ; Serine Endopeptidases/genetics ; Virus Internalization
Czasopismo naukowe
Tytuł :
Long-term personal air pollution exposure and risk for acute exacerbation of idiopathic pulmonary fibrosis.
Autorzy :
Tomos I; 2nd Pulmonary Medicine Department, National and Kapodistrian University of Athens, Medical School, 'ATTIKON' University Hospital, 1, Rimini street, 12462, Haidari, Greece. .
Dimakopoulou K; Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Manali ED; 2nd Pulmonary Medicine Department, National and Kapodistrian University of Athens, Medical School, 'ATTIKON' University Hospital, 1, Rimini street, 12462, Haidari, Greece.
Papiris SA; 2nd Pulmonary Medicine Department, National and Kapodistrian University of Athens, Medical School, 'ATTIKON' University Hospital, 1, Rimini street, 12462, Haidari, Greece.
Karakatsani A; 2nd Pulmonary Medicine Department, National and Kapodistrian University of Athens, Medical School, 'ATTIKON' University Hospital, 1, Rimini street, 12462, Haidari, Greece.
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Źródło :
Environmental health : a global access science source [Environ Health] 2021 Aug 30; Vol. 20 (1), pp. 99. Date of Electronic Publication: 2021 Aug 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Air Pollution/*adverse effects
Environmental Exposure/*adverse effects
Idiopathic Pulmonary Fibrosis/*epidemiology
Aged ; Aged, 80 and over ; Air Pollutants/adverse effects ; Air Pollutants/analysis ; Air Pollution/analysis ; Cytokines/blood ; Disease Progression ; Environmental Exposure/analysis ; Female ; Humans ; Idiopathic Pulmonary Fibrosis/blood ; Male ; Middle Aged ; Nitrogen Dioxide/adverse effects ; Nitrogen Dioxide/analysis ; Ozone/adverse effects ; Ozone/analysis ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Risk Factors ; Telomere
Czasopismo naukowe
Tytuł :
Effectivity of mesenchymal stem cells for bleomycin-induced pulmonary fibrosis: a systematic review and implication for clinical application.
Autorzy :
Zhao Y; Department of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xi Wu Road, Xi'an, 710004, Shaanxi, China.
Yan Z; Department of Liver Diseases, The Hospital Affiliated to Shaanxi University of Chinese Medicine, Xianyang, 712046, China.
Liu Y; The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Zhang Y; The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Shi J; Department of Respiratory, The Hospital Affiliated to Shaanxi University of Chinese Medicine, Xianyang, China.
Li J; Department of Liver Diseases, The Hospital Affiliated to Shaanxi University of Chinese Medicine, Xianyang, 712046, China. .
Ji F; Department of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xi Wu Road, Xi'an, 710004, Shaanxi, China. .; National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. .; Key Laboratory of Environment and Genes Related To Diseases, Xi'an Jiaotong University, Ministry of Education of China, Xi'an, China. .
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Źródło :
Stem cell research & therapy [Stem Cell Res Ther] 2021 Aug 23; Vol. 12 (1), pp. 470. Date of Electronic Publication: 2021 Aug 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review; Systematic Review
MeSH Terms :
COVID-19*
Idiopathic Pulmonary Fibrosis*/chemically induced
Idiopathic Pulmonary Fibrosis*/therapy
Mesenchymal Stem Cell Transplantation*
Bleomycin/adverse effects ; Humans ; Mesenchymal Stem Cells ; Quality of Life
Czasopismo naukowe
Tytuł :
Fibrotic Idiopathic Interstitial Lung Disease: The Molecular and Cellular Key Players.
Autorzy :
Samarelli AV; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41100 Modena, Italy.; Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, 41100 Modena, Italy.
Tonelli R; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41100 Modena, Italy.; Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, 41100 Modena, Italy.; Clinical and Experimental Medicine PhD Program, University of Modena Reggio Emilia, 41100 Modena, Italy.
Marchioni A; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41100 Modena, Italy.; Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, 41100 Modena, Italy.
Bruzzi G; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41100 Modena, Italy.; Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, 41100 Modena, Italy.
Gozzi F; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41100 Modena, Italy.; Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, 41100 Modena, Italy.; Clinical and Experimental Medicine PhD Program, University of Modena Reggio Emilia, 41100 Modena, Italy.
Andrisani D; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41100 Modena, Italy.; Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, 41100 Modena, Italy.; Clinical and Experimental Medicine PhD Program, University of Modena Reggio Emilia, 41100 Modena, Italy.
Castaniere I; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41100 Modena, Italy.; Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, 41100 Modena, Italy.; Clinical and Experimental Medicine PhD Program, University of Modena Reggio Emilia, 41100 Modena, Italy.
Manicardi L; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41100 Modena, Italy.; Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, 41100 Modena, Italy.
Moretti A; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41100 Modena, Italy.; Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, 41100 Modena, Italy.
Tabbì L; Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, 41100 Modena, Italy.
Cerri S; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41100 Modena, Italy.; Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, 41100 Modena, Italy.
Beghè B; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41100 Modena, Italy.; Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, 41100 Modena, Italy.
Dominici M; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41100 Modena, Italy.; Oncology Unit, University Hospital of Modena, University of Modena and Reggio Emilia, 41100 Modena, Italy.
Clini E; Laboratory of Cell Therapies and Respiratory Medicine, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, 41100 Modena, Italy.; Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, 41100 Modena, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 19; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 19.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Gene Expression Regulation*
Biomarkers/*metabolism
Idiopathic Pulmonary Fibrosis/*pathology
Lung Diseases, Interstitial/*pathology
Animals ; Humans ; Idiopathic Pulmonary Fibrosis/genetics ; Idiopathic Pulmonary Fibrosis/metabolism ; Lung Diseases, Interstitial/genetics ; Lung Diseases, Interstitial/metabolism
Czasopismo naukowe
Tytuł :
Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling.
Autorzy :
Cheng D; Department of Occupational Medical and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Xu Q; Department of Occupational Medical and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Wang Y; Department of Occupational Medical and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Li G; Department of Occupational Medical and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Sun W; Department of Occupational Medical and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Ma D; Department of Occupational Medical and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Zhou S; Department of Occupational Medical and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Liu Y; Department of Occupational Medical and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Han L; Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, 210028, China. .
Ni C; Department of Occupational Medical and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. .
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Źródło :
Journal of translational medicine [J Transl Med] 2021 Aug 16; Vol. 19 (1), pp. 349. Date of Electronic Publication: 2021 Aug 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Metformin*/pharmacology
Metformin*/therapeutic use
Pulmonary Fibrosis*/chemically induced
Pulmonary Fibrosis*/drug therapy
AMP-Activated Protein Kinases ; Animals ; Epithelial-Mesenchymal Transition ; Fibroblasts ; Humans ; Lung ; Mice ; Mice, Inbred C57BL ; Silicon Dioxide/toxicity ; Transforming Growth Factor beta1
Czasopismo naukowe
Tytuł :
Coronavirus disease 2019-associated pulmonary fibrosis: clinical findings, pathogenesis, and potential treatment.
Autorzy :
Jiang YL; School of Medicine, Tsinghua University, Beijing 100084, China.
Dai HP; Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, National Clinical Research Center for Respiratory Disease, Beijing 100029, China.
Wang C; Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, National Clinical Research Center for Respiratory Disease, Beijing 100029, China.; Tsinghua University-Peking University Joint Center for Life Sciences, Peking Union Medical College, Beijing 100730, China.
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Źródło :
Chinese medical journal [Chin Med J (Engl)] 2021 Aug 05; Vol. 134 (15), pp. 1792-1794.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19*
Idiopathic Pulmonary Fibrosis*
Pulmonary Fibrosis*
Humans ; SARS-CoV-2
Czasopismo naukowe

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