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Tytuł:
Involvement of microglial P2X7 receptor in pain modulation.
Autorzy:
Zhang J; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Gao L; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Zhang Y; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Wang H; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Sun S; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Wu LA; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Jan; Vol. 30 (1), pp. e14496. Date of Electronic Publication: 2023 Nov 10.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Microglia*
Receptors, Purinergic P2X7*/metabolism
Humans ; Quality of Life ; Pain/metabolism ; Signal Transduction ; Purinergic P2X Receptor Antagonists/pharmacology ; Purinergic P2X Receptor Antagonists/therapeutic use ; Purinergic P2X Receptor Antagonists/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Thrombus remodelling by reversible and irreversible P2Y 12 inhibitors.
Autorzy:
Tunströmer K; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Faxälv L; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Larsson P; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.; Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia.
Lindahl TL; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.; Department of Clinical Chemistry and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Boknäs N; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.; Department of Hematology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
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Źródło:
Platelets [Platelets] 2023 Dec; Vol. 34 (1), pp. 2157805.
Typ publikacji:
Journal Article
MeSH Terms:
Acute Coronary Syndrome*/drug therapy
Platelet Aggregation Inhibitors*/therapeutic use
Purinergic P2Y Receptor Antagonists*/therapeutic use
Thrombosis*/drug therapy
Thrombosis*/metabolism
Humans ; Blood Platelets/metabolism ; Fibrinolytic Agents/therapeutic use ; Prasugrel Hydrochloride/pharmacology ; Prasugrel Hydrochloride/therapeutic use ; Receptors, Purinergic P2Y12/metabolism ; Ticagrelor/pharmacology ; Ticagrelor/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
On the basis of sex: male vs. female rat adenosine A 1 /A 2A receptor affinity.
Autorzy:
Janse van Rensburg HD; Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa. .
Terre'Blanche G; Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.; Department of Pharmaceutical Chemistry, School of Pharmacy, North-West University, Potchefstroom, South Africa.
Van der Walt MM; Human Metabolomics, North-West University, Potchefstroom, South Africa.
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Źródło:
BMC research notes [BMC Res Notes] 2023 Aug 10; Vol. 16 (1), pp. 165. Date of Electronic Publication: 2023 Aug 10.
Typ publikacji:
Journal Article
MeSH Terms:
Adenosine*/pharmacology
Purinergic P1 Receptor Antagonists*
Female ; Rats ; Male ; Animals ; Rats, Sprague-Dawley ; Ligands ; Pilot Projects ; Reproducibility of Results ; Receptors, Purinergic P1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
P2X7 receptor antagonism by AZ10606120 significantly reduced in vitro tumour growth in human glioblastoma.
Autorzy:
Kan LK; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Drill M; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Jayakrishnan PC; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Sequeira RP; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Galea E; Department of Neurosurgery, The Alfred, Melbourne, VIC, Australia.
Todaro M; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia.; Department of Neurology, The Royal Melbourne Hospital, Melbourne, VIC, Australia.; Department of Neurology, The Alfred, Melbourne, VIC, Australia.
Sanfilippo PG; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Hunn M; Department of Neurosurgery, The Alfred, Melbourne, VIC, Australia.
Williams DA; Department of Physiology, The University of Melbourne, Melbourne, VIC, Australia.
O'Brien TJ; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia.; Department of Neurology, The Royal Melbourne Hospital, Melbourne, VIC, Australia.; Department of Neurology, The Alfred, Melbourne, VIC, Australia.
Drummond KJ; Department of Neurosurgery, The Royal Melbourne Hospital, Melbourne, VIC, Australia.
Monif M; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia. .; Department of Physiology, The University of Melbourne, Melbourne, VIC, Australia. .; Department of Neurology, The Royal Melbourne Hospital, Melbourne, VIC, Australia. .; Department of Neurology, The Alfred, Melbourne, VIC, Australia. .
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Źródło:
Scientific reports [Sci Rep] 2023 May 24; Vol. 13 (1), pp. 8435. Date of Electronic Publication: 2023 May 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adamantane*/analogs & derivatives
Adamantane*/pharmacology
Glioblastoma*/drug therapy
Purinergic P2X Receptor Antagonists*/pharmacology
Humans ; Aminoquinolines/pharmacology ; Receptors, Purinergic P2X7 ; Temozolomide/pharmacology ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Unlocking the Conformational Changes of P2Y 12 : Exploring an Acridinone Compound's Effect on Receptor Activity and Conformation.
Autorzy:
Al-Najjar BO; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.; Diagnostic Research Centre, Al-Ahliyya Amman University, Amman 19328, Jordan.
Saqallah FG; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.; Diagnostic Research Centre, Al-Ahliyya Amman University, Amman 19328, Jordan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 May 04; Vol. 28 (9). Date of Electronic Publication: 2023 May 04.
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Dynamics Simulation*
Receptors, Purinergic P2Y12*
Protein Structure, Secondary ; Purinergic P2Y Receptor Antagonists
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Signaling Pathway of the ADP Receptor P2Y 12 in the Immune System: Recent Discoveries and New Challenges.
Autorzy:
Entsie P; Department of Pharmaceutical Sciences, School of Pharmacy, College of Health Professions, North Dakota State University, Fargo, ND 58105, USA.
Kang Y; Department of Pharmaceutical Sciences, School of Pharmacy, College of Health Professions, North Dakota State University, Fargo, ND 58105, USA.
Amoafo EB; Department of Pharmaceutical Sciences, School of Pharmacy, College of Health Professions, North Dakota State University, Fargo, ND 58105, USA.
Schöneberg T; Division of Molecular Biochemistry, Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, 04103 Leipzig, Germany.
Liverani E; Department of Pharmaceutical Sciences, School of Pharmacy, College of Health Professions, North Dakota State University, Fargo, ND 58105, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Apr 04; Vol. 24 (7). Date of Electronic Publication: 2023 Apr 04.
Typ publikacji:
Journal Article; Review
MeSH Terms:
COVID-19*/metabolism
Receptors, Purinergic P2*/metabolism
Animals ; Humans ; Purinergic P2Y Receptor Antagonists/pharmacology ; Purinergic P2Y Receptor Antagonists/therapeutic use ; Blood Platelets/metabolism ; Signal Transduction ; Immune System ; Receptors, Purinergic P2Y12/genetics ; Receptors, Purinergic P2Y12/metabolism ; Platelet Aggregation ; Platelet Aggregation Inhibitors/pharmacology ; Adenosine Diphosphate/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Purinergic P2 Receptors: Structure and Function 2.0.
Autorzy:
Zemkova H; Institute of Physiology, Czech Academy of Sciences, 14220 Prague, Czech Republic.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 13; Vol. 24 (6). Date of Electronic Publication: 2023 Mar 13.
Typ publikacji:
Editorial
MeSH Terms:
Adenosine Triphosphate*
Receptors, Purinergic P2*
Signal Transduction ; Receptors, Purinergic P1 ; Purinergic P2 Receptor Antagonists
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
STAT1- and NFAT-independent amplification of purinoceptor function integrates cellular senescence with interleukin-6 production in preadipocytes.
Autorzy:
Majeed Y; Department of Microbiology and Immunology, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar.
Madani AY; Department of Microbiology and Immunology, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar.
Altamimi AI; Department of Microbiology and Immunology, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar.
Courjaret R; Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar.
Vakayil M; Department of Microbiology and Immunology, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar.; College of Health and Life Sciences, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.
Fountain SJ; School of Biological Sciences, University of East Anglia, Norwich, UK.
Machaca K; Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar.
Mazloum NA; Department of Microbiology and Immunology, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2023 Mar; Vol. 180 (5), pp. 609-627. Date of Electronic Publication: 2022 Nov 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, Purinergic P2*/metabolism
Hemangiosarcoma*
Mice ; Animals ; Interleukin-6 ; Calcium/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Adenosine Triphosphate/metabolism ; Receptors, Purinergic/metabolism ; Cellular Senescence ; Inflammation ; STAT1 Transcription Factor/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
C2-linked alkynyl poly-ethylene glycol(PEG) adenosine conjugates as water-soluble adenosine receptor agonists.
Autorzy:
Ferguson L; School of Science, University of the West of Scotland, Paisley, UK.
Madieh NS; Leicester School of Pharmacy, De Montfort University, Leicester, UK.
Vaideanu A; UCL School of Pharmacy, University College London, London, UK.
Schatzlein A; UCL School of Pharmacy, University College London, London, UK.
Festa J; Leicester School of Allied Health Sciences, De Montfort University, Leicester, UK.
Singh H; Leicester School of Allied Health Sciences, De Montfort University, Leicester, UK.
Wells G; UCL School of Pharmacy, University College London, London, UK.
Bhakta S; Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, London, UK.
Brucoli F; Leicester School of Pharmacy, De Montfort University, Leicester, UK.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2023 Feb; Vol. 101 (2), pp. 340-349. Date of Electronic Publication: 2022 Aug 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenosine*/pharmacology
Adenosine*/metabolism
Purinergic P1 Receptor Agonists*
Mice ; Animals ; Polyethylene Glycols ; Receptors, Purinergic P1/metabolism ; Protein Binding ; Receptor, Adenosine A2A/metabolism ; Receptor, Adenosine A3
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evidence for a PI3-kinase independent pathway in the regulation of Rap1b activation downstream of the P2Y12 receptor in platelets.
Autorzy:
Dangelmaier C; Sol Sherry Thrombosis Research Center and the Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Kunapuli SP; Sol Sherry Thrombosis Research Center and the Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
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Źródło:
Platelets [Platelets] 2022 Nov 17; Vol. 33 (8), pp. 1301-1306. Date of Electronic Publication: 2022 May 06.
Typ publikacji:
Journal Article
MeSH Terms:
Phosphatidylinositol 3-Kinases*/metabolism
Receptors, Purinergic P2*/metabolism
Adenosine Diphosphate/analogs & derivatives ; Adenosine Diphosphate/metabolism ; Adenosine Diphosphate/pharmacology ; Adenylyl Cyclases/metabolism ; Blood Platelets/metabolism ; Calcium/metabolism ; Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Purinergic P2Y Receptor Antagonists ; Receptors, Purinergic P2Y1/metabolism ; Receptors, Purinergic P2Y12/metabolism ; Thionucleotides ; Type C Phospholipases/metabolism ; rap GTP-Binding Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis, Biological Evaluation and Molecular Modeling Studies of Naphthoquinone Sulfonamides and Sulfonate Ester Derivatives as P2X7 Inhibitors.
Autorzy:
Pacheco PAF; Department of Organic Chemistry, Institute of Chemistry, Federal Fluminense University, Niterói 24020-141, Brazil.
Gonzaga DTG; Departament of Pharmacy, West Zone Campus, State University of Rio de Janeiro, Rio de Janeiro 23070-200, Brazil.
von Ranke NL; Department of Pharmaceuticals and Medicines, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21941-170, Brazil.
Rodrigues CR; Department of Pharmaceuticals and Medicines, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21941-170, Brazil.
da Rocha DR; Department of Organic Chemistry, Institute of Chemistry, Federal Fluminense University, Niterói 24020-141, Brazil.
da Silva FC; Department of Organic Chemistry, Institute of Chemistry, Federal Fluminense University, Niterói 24020-141, Brazil.
Ferreira VF; Department of Organic Chemistry, Institute of Chemistry, Federal Fluminense University, Niterói 24020-141, Brazil.
Faria RX; Evaluation and Promotion of the Ambiental Health Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, Brazil.; Postgraduate Program in Sciences and Biotechnology, Institute of Biology, Federal Fluminense University, Niterói 24210-130, Brazil.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Jan 06; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
Purinergic P2X Receptor Antagonists*/pharmacology
Purinergic P2X Receptor Antagonists*/chemistry
Naphthoquinones*/pharmacology
Naphthoquinones*/chemistry
Sulfonamides/pharmacology ; Molecular Docking Simulation ; Receptors, Purinergic P2X7 ; Adenosine Triphosphate/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
P2X7 receptor antagonists modulate experimental autoimmune neuritis via regulation of NLRP3 inflammasome activation and Th17 and Th1 cell differentiation.
Autorzy:
Xie Y; Department of Neurology, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, 300052, China.; Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Han R; Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Li Y; Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Li W; Department of Neurology, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, 300052, China.; Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Zhang S; Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300102, China.
Wu Y; Department of Neurology, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, 300052, China.
Zhao Y; Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Liu R; Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Wu J; Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Jiang W; Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China. .; Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. .
Chen X; Department of Neurology, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, 300052, China. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2024 Mar 25; Vol. 21 (1), pp. 73. Date of Electronic Publication: 2024 Mar 25.
Typ publikacji:
Journal Article
MeSH Terms:
Guillain-Barre Syndrome*/drug therapy
Neuritis, Autoimmune, Experimental*
Purinergic P2X Receptor Antagonists*/pharmacology
Purinergic P2X Receptor Antagonists*/therapeutic use
Animals ; Humans ; Rats ; CD8-Positive T-Lymphocytes ; Cell Differentiation/drug effects ; Inflammasomes/drug effects ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Sciatic Nerve/metabolism ; Th17 Cells/drug effects ; Th17 Cells/metabolism ; Th1 Cells/drug effects ; Th1 Cells/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
P2X7 Receptor in Dendritic Cells and Macrophages: Implications in Antigen Presentation and T Lymphocyte Activation.
Autorzy:
Acuña-Castillo C; Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9160000, Chile.; Centro de Biotecnología Acuícola, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9160000, Chile.
Escobar A; Laboratorio Biología Celular y Molecular, Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, Santiago 8380000, Chile.
García-Gómez M; Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago 7800003, Chile.
Bachelet VC; Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago 9160000, Chile.
Huidobro-Toro JP; Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9160000, Chile.
Sauma D; Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago 7800003, Chile.; Centro Ciencia & Vida, Av. Del Valle Norte 725, Huechuraba 8580000, Chile.
Barrera-Avalos C; Centro de Biotecnología Acuícola, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9160000, Chile.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 21; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Receptors, Purinergic P2X7*
Antigen Presentation*
Lymphocyte Activation ; Macrophages ; Dendritic Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ionotropic P2X4 and P2X7 receptors in the regulation of ion transport across rat colon.
Autorzy:
Ballout J; Institute for Veterinary Physiology and Biochemistry, Justus Liebig University Giessen, Giessen, Germany.
Claßen R; Institute for Veterinary Physiology and Biochemistry, Justus Liebig University Giessen, Giessen, Germany.
Richter K; Laboratory of Experimental Surgery, Department of General Surgery, German Centre for Lung Research (DZL), Justus Liebig University Giessen, Giessen, Germany.
Grau V; Laboratory of Experimental Surgery, Department of General Surgery, German Centre for Lung Research (DZL), Justus Liebig University Giessen, Giessen, Germany.
Diener M; Institute for Veterinary Physiology and Biochemistry, Justus Liebig University Giessen, Giessen, Germany.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2022 Nov; Vol. 179 (21), pp. 4992-5011. Date of Electronic Publication: 2022 Aug 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenosine Triphosphate*/metabolism
Adenosine Triphosphate*/pharmacology
Receptors, Purinergic P2X7*/metabolism
Animals ; Colon/metabolism ; Ion Transport ; Rats ; Receptors, Purinergic P2X4/metabolism ; Tetrodotoxin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions.
Autorzy:
Wilmes M; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Pinto Espinoza C; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Ludewig P; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Stabernack J; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Liesz A; Institute for Stroke and Dementia Research, University Medical Center, 813777, Munich, Germany.; Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.
Nicke A; SyNergy Cluster for Systems Neurology, 81377, Munich, Germany.
Gelderblom M; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Gerloff C; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Falzoni S; Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Tolosa E; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Di Virgilio F; Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Rissiek B; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Plesnilla N; Institute for Stroke and Dementia Research, University Medical Center, 813777, Munich, Germany.
Koch-Nolte F; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Magnus T; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2022 Oct 12; Vol. 19 (1), pp. 256. Date of Electronic Publication: 2022 Oct 12.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, Purinergic P2*/metabolism
Single-Domain Antibodies*/metabolism
Stroke*/metabolism
Adenosine Triphosphate/pharmacology ; Animals ; Calcium/metabolism ; Caspase 1/metabolism ; Infarction, Middle Cerebral Artery/pathology ; Interleukin-1beta/metabolism ; Mice ; Microglia/metabolism ; Receptors, Purinergic P2X7/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pyrazolo-triazolo-pyrimidine Scaffold as a Molecular Passepartout for the Pan-Recognition of Human Adenosine Receptors.
Autorzy:
Salmaso V; Molecular Modeling Section (MMS), Dipartimento di Scienze del Farmaco, Università di Padova, Via Marzolo 5, I-35131 Padova, Italy.
Persico M; Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, Via Licio Giorgieri 1, I-34127 Trieste, Italy.
Da Ros T; Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, Via Licio Giorgieri 1, I-34127 Trieste, Italy.
Spalluto G; Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, Via Licio Giorgieri 1, I-34127 Trieste, Italy.
Kachler S; Institut für Pharmakologie, Universität of Würzburg, Versbacher Str. 9, D-97078 Würzburg, Germany.
Klotz KN; Institut für Pharmakologie, Universität of Würzburg, Versbacher Str. 9, D-97078 Würzburg, Germany.
Moro S; Molecular Modeling Section (MMS), Dipartimento di Scienze del Farmaco, Università di Padova, Via Marzolo 5, I-35131 Padova, Italy.
Federico S; Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, Via Licio Giorgieri 1, I-34127 Trieste, Italy.
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Źródło:
Biomolecules [Biomolecules] 2023 Nov 03; Vol. 13 (11). Date of Electronic Publication: 2023 Nov 03.
Typ publikacji:
Journal Article
MeSH Terms:
Purinergic P1 Receptor Antagonists*/pharmacology
Receptors, Purinergic P1*
Humans ; Structure-Activity Relationship ; Models, Molecular ; Pyrimidines/pharmacology ; Pyrimidines/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prototypic P2X7 Receptor Agonist, BzATP, Induced the Expression of Unfolded Protein Response Genes in Human M1 Macrophages.
Autorzy:
Akhtari M; Department of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran AND Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Inflammation Research Center, Tehran University of Medical Sciences, Tehran, Iran. .
Jalal Zargar S; Department of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran. .
Javinani A; Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran. .
Ashraf-Ganjouei A; Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran. .
Vojdanian M; Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran. .
Jamshidi A; Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran. .
Mahmoudi M; Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran 3 Inflammation Research Center, Tehran University of Medical Sciences, Tehran, Iran. .
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Źródło:
Iranian journal of allergy, asthma, and immunology [Iran J Allergy Asthma Immunol] 2022 Feb 06; Vol. 21 (1), pp. 73-80. Date of Electronic Publication: 2022 Feb 06.
Typ publikacji:
Journal Article
MeSH Terms:
Adenosine Triphosphate*/analogs & derivatives
Adenosine Triphosphate*/pharmacology
Macrophages*/metabolism
Purinergic P2X Receptor Agonists*/pharmacology
Unfolded Protein Response*
Humans ; Receptors, Purinergic P2X7/genetics ; Receptors, Purinergic P2X7/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Off-Target Effects of P2Y12 Receptor Inhibitors: Focus on Early Myocardial Fibrosis Modulation.
Autorzy:
Lofrumento F; Department of Clinical and Experimental Medicine, Policlinic 'G. Martino', University of Messina, 98122 Messina, Italy.
Irrera N; Department of Clinical and Experimental Medicine, Policlinic 'G. Martino', University of Messina, 98122 Messina, Italy.
Licordari R; Department of Clinical and Experimental Medicine, Policlinic 'G. Martino', University of Messina, 98122 Messina, Italy.
Perfetti S; Department of Clinical and Experimental Medicine, Policlinic 'G. Martino', University of Messina, 98122 Messina, Italy.
Nasso E; Department of Clinical and Experimental Medicine, Policlinic 'G. Martino', University of Messina, 98122 Messina, Italy.
Liotta P; Department of Clinical and Experimental Medicine, Policlinic 'G. Martino', University of Messina, 98122 Messina, Italy.
Isgrò G; Department of Clinical and Experimental Medicine, Policlinic 'G. Martino', University of Messina, 98122 Messina, Italy.
Garcia-Ruiz V; Cardiology Department, GIOMI Hospital, 98165 Messina, Italy.
Squadrito F; Department of Clinical and Experimental Medicine, Policlinic 'G. Martino', University of Messina, 98122 Messina, Italy.
Carerj S; Department of Clinical and Experimental Medicine, Policlinic 'G. Martino', University of Messina, 98122 Messina, Italy.
Di Bella G; Department of Clinical and Experimental Medicine, Policlinic 'G. Martino', University of Messina, 98122 Messina, Italy.
Micari A; BIOMORF Department, Policlinic 'G. Martino', University of Messina, 98122 Messina, Italy.
Costa F; BIOMORF Department, Policlinic 'G. Martino', University of Messina, 98122 Messina, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 16; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 16.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Purinergic P2Y Receptor Antagonists*/pharmacology
Purinergic P2Y Receptor Antagonists*/therapeutic use
Myocardial Infarction*/metabolism
Humans ; Ticagrelor/pharmacology ; beta Catenin ; Adenosine ; Pericardium/metabolism ; Fibrosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Naringin inhibits P2X4 receptor expression on satellite glial cells in the neonatal rat dorsal root ganglion.
Autorzy:
Wang H; Basic Medical College of Nanchang University, Department of Physiology, Nanchang, 330006, P.R. China.
Chen L; Basic Medical College of Nanchang University, Department of Physiology, Nanchang, 330006, P.R. China.
Xing J; Basic Medical College of Nanchang University, Department of Physiology, Nanchang, 330006, P.R. China.
Shi X; Basic Medical College of Nanchang University, Department of Physiology, Nanchang, 330006, P.R. China.
Xu C; Basic Medical College of Nanchang University, Department of Physiology, Nanchang, 330006, P.R. China.; Jiangxi Provincial Key Laboratory of autonomic nervous function and disease, Nanchang, 330006, P.R. China.; Jiangxi Medical College, School of Clinical Medicine, Shangrao, 334000, P.R. China.; Jiangxi Medical College, The First Affiliated Hospital, Shangrao, 334000, P.R. China.
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Źródło:
Journal of applied biomedicine [J Appl Biomed] 2023 Dec; Vol. 21 (4), pp. 193-199. Date of Electronic Publication: 2023 Dec 04.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, Purinergic P2X4*/genetics
Receptors, Purinergic P2X4*/metabolism
NF-kappa B*/metabolism
Rats ; Animals ; Animals, Newborn ; Rats, Sprague-Dawley ; Ganglia, Spinal/metabolism ; Calcium/metabolism ; Calcium/pharmacology ; Neuroglia/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism ; p38 Mitogen-Activated Protein Kinases/pharmacology ; Inflammation ; Adenosine Triphosphate/metabolism ; Adenosine Triphosphate/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
P2X7 Receptor-Induced Human Mast Cell Degranulation Is Enhanced by Interleukin 33.
Autorzy:
Salcman B; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9NT, UK.
Bahri R; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9NT, UK.
West PW; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9NT, UK.
Tontini C; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9NT, UK.
Affleck K; GlaxoSmithKline, Stevenage SG1 2NY, UK.
Bulfone-Paus S; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9NT, UK.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 31; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 31.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Degranulation*/genetics
Cell Degranulation*/physiology
Interleukin-33*/pharmacology
Interleukin-33*/metabolism
Receptors, Purinergic P2X7*/metabolism
Humans ; Adenosine Triphosphate/pharmacology ; Adenosine Triphosphate/metabolism ; Mast Cells/metabolism ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 12271

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