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Wyszukujesz frazę ""Purinergic"" wg kryterium: Temat


Tytuł :
P2X7R: pivotal player in sepsis-induced liver damage.
Autorzy :
Vuerich M; Department of Anesthesia, Critical Care & Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA. .
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Źródło :
Purinergic signalling [Purinergic Signal] 2020 Dec; Vol. 16 (4), pp. 473-474. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Receptors, Purinergic P2X7*
Sepsis*
Humans ; Oxidative Stress ; Purinergic P2X Receptor Antagonists
Czasopismo naukowe
Tytuł :
Potential and Limitations of the New P2Y12 Inhibitor, Cangrelor, in Preventing Heparin-Induced Platelet Aggregation During Cardiac Surgery: An In Vitro Study.
Autorzy :
Scala E; From the Department of Anesthesiology.; Division of Hematology, Department of Oncology and Central Hematology Laboratory, Department of Laboratory Medicine and Pathology, Lausanne University Hospital (Centre Hospitalier Universitaire Vaudois [CHUV]) and University of Lausanne (UNIL), Lausanne, Switzerland.
Gerschheimer C; Division of Hematology, Department of Oncology and Central Hematology Laboratory, Department of Laboratory Medicine and Pathology, Lausanne University Hospital (Centre Hospitalier Universitaire Vaudois [CHUV]) and University of Lausanne (UNIL), Lausanne, Switzerland.
Gomez FJ; Division of Hematology, Department of Oncology and Central Hematology Laboratory, Department of Laboratory Medicine and Pathology, Lausanne University Hospital (Centre Hospitalier Universitaire Vaudois [CHUV]) and University of Lausanne (UNIL), Lausanne, Switzerland.
Alberio L; Division of Hematology, Department of Oncology and Central Hematology Laboratory, Department of Laboratory Medicine and Pathology, Lausanne University Hospital (Centre Hospitalier Universitaire Vaudois [CHUV]) and University of Lausanne (UNIL), Lausanne, Switzerland.
Marcucci C; From the Department of Anesthesiology.
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Źródło :
Anesthesia and analgesia [Anesth Analg] 2020 Aug; Vol. 131 (2), pp. 622-630.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, Purinergic P2Y12*/blood
Adenosine Monophosphate/*analogs & derivatives
Anticoagulants/*adverse effects
Cardiac Surgical Procedures/*methods
Heparin/*adverse effects
Platelet Aggregation/*drug effects
Purinergic P2Y Receptor Antagonists/*pharmacology
Adenosine Monophosphate/blood ; Adenosine Monophosphate/pharmacology ; Anticoagulants/blood ; Cardiac Surgical Procedures/adverse effects ; Heparin/blood ; Humans ; Platelet Aggregation/physiology ; Purinergic P2Y Receptor Antagonists/blood
Czasopismo naukowe
Tytuł :
P2Y 2 and P2X4 Receptors Mediate Ca Mobilization in DH82 Canine Macrophage Cells.
Autorzy :
Sophocleous RA; Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia.
Miles NA; Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia.
Ooi L; Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia.
Sluyter R; Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 13; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium Signaling*
Calcium/*metabolism
Macrophages/*metabolism
Receptors, Purinergic P2X4/*metabolism
Receptors, Purinergic P2Y2/*metabolism
Animals ; Cell Line ; Dogs ; Macrophages/cytology ; Purinergic P2X Receptor Antagonists/pharmacology ; Purinergic P2Y Receptor Antagonists/pharmacology
Czasopismo naukowe
Tytuł :
P2X7 receptors and glioma cells.
Autorzy :
Bergamin LS; Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Via Fossato di Mortara, 74, 44121, Ferrara, Italy. .
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Źródło :
Purinergic signalling [Purinergic Signal] 2020 Sep; Vol. 16 (3), pp. 253-254. Date of Electronic Publication: 2020 Sep 01.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Glioma*
Receptors, Purinergic P2X7*
Humans ; Purinergic P2X Receptor Antagonists
Czasopismo naukowe
Tytuł :
Managing unexplained chronic cough in adults: what are the unmet needs?
Autorzy :
Irwin RS; The Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: .
French CL; The Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Madison JM; The Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
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Źródło :
The Lancet. Respiratory medicine [Lancet Respir Med] 2020 Aug; Vol. 8 (8), pp. 745-747. Date of Electronic Publication: 2020 Feb 25.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Cough*
Purinergic P2X Receptor Antagonists*
Adult ; Chronic Disease ; Double-Blind Method ; Health Services Needs and Demand ; Humans ; Receptors, Purinergic P2X3
Czasopismo naukowe
Tytuł :
Dihydrotanshinone, a Natural Diterpenoid, Preserves Blood-Retinal Barrier Integrity via P2X7 Receptor.
Autorzy :
Fresta CG; Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95125 Catania, Italy.
Caruso G; Department of Drug Sciences, University of Catania, 95125 Catania, Italy.; Oasi Research Institute-IRCCS, 94018 Troina, Italy.
Fidilio A; Department of Drug Sciences, University of Catania, 95125 Catania, Italy.
Platania CBM; Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95125 Catania, Italy.
Musso N; Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95125 Catania, Italy.
Caraci F; Department of Drug Sciences, University of Catania, 95125 Catania, Italy.; Oasi Research Institute-IRCCS, 94018 Troina, Italy.
Drago F; Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95125 Catania, Italy.; Center for Research in Ocular Pharmacology-CERFO, University of Catania, 95125 Catania, Italy.
Bucolo C; Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95125 Catania, Italy.; Center for Research in Ocular Pharmacology-CERFO, University of Catania, 95125 Catania, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 06; Vol. 21 (23). Date of Electronic Publication: 2020 Dec 06.
Typ publikacji :
Journal Article
MeSH Terms :
Blood-Retinal Barrier/*drug effects
Furans/*pharmacology
Phenanthrenes/*pharmacology
Purinergic P2X Receptor Antagonists/*pharmacology
Receptors, Purinergic P2X7/*metabolism
Adenosine Triphosphate/analogs & derivatives ; Adenosine Triphosphate/toxicity ; Astrocytes/drug effects ; Astrocytes/metabolism ; Binding Sites ; Blood-Retinal Barrier/cytology ; Blood-Retinal Barrier/metabolism ; Capillary Permeability ; Cell Line ; Connexin 43/metabolism ; Cytokines/metabolism ; Cytoprotection ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Furans/chemistry ; Humans ; Pericytes/drug effects ; Pericytes/metabolism ; Phenanthrenes/chemistry ; Protein Binding ; Purinergic P2X Receptor Agonists/toxicity ; Purinergic P2X Receptor Antagonists/chemistry ; Reactive Oxygen Species/metabolism ; Receptors, Purinergic P2X7/chemistry
Czasopismo naukowe
Tytuł :
Dissection of P2X4 and P2X7 Receptor Current Components in BV-2 Microglia.
Autorzy :
Trang M; Julius-Bernstein-Institute for Physiology, Martin-Luther-University, D-06097 Halle-Wittenberg, Germany.
Schmalzing G; Institute of Clinical Pharmacology, RWTH Aachen University, D-52074 Aachen, Germany.
Müller CE; Pharmaceutical Institute, Pharmaceutical & Mediinal Chemistry, University of Bonn, D-53121 Bonn, Germany.
Markwardt F; Julius-Bernstein-Institute for Physiology, Martin-Luther-University, D-06097 Halle-Wittenberg, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 11; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :
Journal Article
MeSH Terms :
Microglia/*metabolism
Receptors, Purinergic P2X4/*metabolism
Receptors, Purinergic P2X7/*metabolism
Animals ; Cells, Cultured ; Female ; Interferon-gamma/metabolism ; Lipopolysaccharides/metabolism ; Mice ; Microglia/drug effects ; Patch-Clamp Techniques/methods ; Protein Subunits/metabolism ; Purinergic P2X Receptor Antagonists/pharmacology ; Up-Regulation/drug effects ; Up-Regulation/physiology ; Xenopus laevis/metabolism
Czasopismo naukowe
Tytuł :
Comparison of platelet reactivity between prasugrel and ticagrelor in patients with acute coronary syndrome: a meta-analysis.
Autorzy :
Wen M; Intensive Care Unit, Guizhou Provincial People's Hospital, No. 58 Zhongshan East Road, Nanming District, Guiyang, 550002, Guizhou, China. .
Li Y; Emergency Department, Guizhou Provincial People's Hospital, Guiyang, 550002, Guizhou, China.
Qu X; Emergency Department, Guizhou Provincial People's Hospital, Guiyang, 550002, Guizhou, China.
Zhu Y; Radiology Department, Guizhou Provincial People's Hospital, Guiyang, 550002, Guizhou, China.
Tian L; Endocrine Department, The First People's Hospital of Guiyang, Guiyang, 550002, Guizhou, China.
Shen Z; Endocrine Department, The First People's Hospital of Guiyang, Guiyang, 550002, Guizhou, China.
Yang X; Emergency Department, Guizhou Provincial People's Hospital, Guiyang, 550002, Guizhou, China.
Shi X; Intensive Care Unit, Guizhou Provincial People's Hospital, No. 58 Zhongshan East Road, Nanming District, Guiyang, 550002, Guizhou, China. .
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Źródło :
BMC cardiovascular disorders [BMC Cardiovasc Disord] 2020 Oct 01; Vol. 20 (1), pp. 430. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Acute Coronary Syndrome/*drug therapy
Blood Platelets/*drug effects
Platelet Aggregation Inhibitors/*therapeutic use
Prasugrel Hydrochloride/*therapeutic use
Purinergic P2Y Receptor Antagonists/*therapeutic use
Ticagrelor/*therapeutic use
Acute Coronary Syndrome/blood ; Acute Coronary Syndrome/diagnosis ; Aged ; Blood Platelets/metabolism ; Cell Adhesion Molecules/blood ; Female ; Humans ; Male ; Microfilament Proteins/blood ; Middle Aged ; Phosphoproteins/blood ; Platelet Aggregation Inhibitors/adverse effects ; Platelet Function Tests ; Prasugrel Hydrochloride/adverse effects ; Purinergic P2Y Receptor Antagonists/adverse effects ; Receptors, Purinergic P2Y12/blood ; Receptors, Purinergic P2Y12/drug effects ; Ticagrelor/adverse effects ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Potential Therapeutic Role of Purinergic Receptors in Cardiovascular Disease Mediated by SARS-CoV-2.
Autorzy :
Dos Anjos F; Medical School, Federal University of Fronteira Sul, Chapecó, SC, Brazil.
Simões JLB; Medical School, Federal University of Fronteira Sul, Chapecó, SC, Brazil.
Assmann CE; Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Carvalho FB; Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil.
Bagatini MD; Graduate Program in Biomedical Sciences, Federal University of Fronteira Sul, Chapecó, SC, Brazil.
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Źródło :
Journal of immunology research [J Immunol Res] 2020 Dec 01; Vol. 2020, pp. 8632048. Date of Electronic Publication: 2020 Dec 01 (Print Publication: 2020).
Typ publikacji :
Journal Article; Review
MeSH Terms :
SARS-CoV-2*
Adenosine Triphosphate/*metabolism
COVID-19/*immunology
Cardiovascular Diseases/*virology
Receptors, Purinergic/*metabolism
Adenosine A2 Receptor Agonists/pharmacology ; COVID-19/drug therapy ; COVID-19/metabolism ; Cardiovascular Diseases/immunology ; Cardiovascular Diseases/physiopathology ; Cytokines/metabolism ; Humans ; Myocardial Ischemia/immunology ; Myocardial Ischemia/physiopathology ; Myocardial Ischemia/virology ; Pandemics ; Purinergic Antagonists/pharmacology ; Receptor, Adenosine A2A/metabolism ; Receptor, Adenosine A3/metabolism ; Signal Transduction/drug effects ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
P2X7R orchestrates the progression of murine hepatic fibrosis by making a feedback loop from macrophage to hepatic stellate cells.
Autorzy :
Jiang M; Key Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, Jilin Province, 133002, China.
Cui BW; Key Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, Jilin Province, 133002, China.
Wu YL; Key Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, Jilin Province, 133002, China.
Zhang Y; Key Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, Jilin Province, 133002, China.
Shang Y; Key Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, Jilin Province, 133002, China.
Liu J; Key Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, Jilin Province, 133002, China.
Yang HX; Key Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, Jilin Province, 133002, China.
Qiao CY; Key Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, Jilin Province, 133002, China.
Zhan ZY; Key Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, Jilin Province, 133002, China.
Ye H; Key Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, Jilin Province, 133002, China.
Jin Q; Key Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, Jilin Province, 133002, China.
Nan JX; Key Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, Jilin Province, 133002, China; Clinical Research Center, Yanbian University Hospital, Yanji, Jilin Province, 133002, China. Electronic address: .
Lian LH; Key Laboratory for Traditional Chinese Korean Medicine of Jilin Province, College of Pharmacy, Yanbian University, Yanji, Jilin Province, 133002, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Oct 15; Vol. 333, pp. 22-32. Date of Electronic Publication: 2020 Jul 25.
Typ publikacji :
Journal Article
MeSH Terms :
Chemical and Drug Induced Liver Injury/*metabolism
Hepatic Stellate Cells/*drug effects
Liver Cirrhosis/*metabolism
Macrophages, Peritoneal/*drug effects
Receptors, Purinergic P2X7/*metabolism
Animals ; Cell Culture Techniques ; Cell Line, Tumor ; Chemical and Drug Induced Liver Injury/pathology ; Disease Models, Animal ; Extracellular Matrix/drug effects ; Extracellular Matrix/metabolism ; Feedback, Physiological ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Humans ; Liver Cirrhosis/pathology ; Macrophages, Peritoneal/metabolism ; Macrophages, Peritoneal/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Purinergic P2X Receptor Antagonists/pharmacology ; Pyridines/pharmacology ; Tetrazoles/pharmacology ; Thioacetamide/toxicity
Czasopismo naukowe
Tytuł :
P2X3 and P2X2/3 receptors activation induces articular hyperalgesia by an indirect sensitization of the primary afferent nociceptor in the rats' knee joint.
Autorzy :
Teixeira JM; Department of Structural and Functional Biology, Institute of Biology, State University of Campinas, UNICAMP, Brazil. Electronic address: .
Parada CA; Department of Structural and Functional Biology, Institute of Biology, State University of Campinas, UNICAMP, Brazil.
Tambeli CH; Department of Structural and Functional Biology, Institute of Biology, State University of Campinas, UNICAMP, Brazil. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 Jul 15; Vol. 879, pp. 173054. Date of Electronic Publication: 2020 Mar 04.
Typ publikacji :
Journal Article
MeSH Terms :
Hyperalgesia/*metabolism
Receptors, Purinergic P2X2/*metabolism
Receptors, Purinergic P2X3/*metabolism
Adenosine Triphosphate/analogs & derivatives ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Bradykinin ; Cytokines/immunology ; Dinoprostone ; Dopamine ; Hyperalgesia/chemically induced ; Hyperalgesia/immunology ; Knee Joint/immunology ; Knee Joint/metabolism ; Male ; Neutrophils/drug effects ; Phenols/pharmacology ; Phenols/therapeutic use ; Polycyclic Compounds/pharmacology ; Polycyclic Compounds/therapeutic use ; Purinergic P2X Receptor Agonists ; Purinergic P2X Receptor Antagonists/pharmacology ; Purinergic P2X Receptor Antagonists/therapeutic use ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Unravelling purinergic regulation in the epididymis: activation of V-ATPase-dependent acidification by luminal ATP and adenosine.
Autorzy :
Battistone MA; Program in Membrane Biology, Center for System Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Merkulova M; Program in Membrane Biology, Center for System Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Park YJ; Program in Membrane Biology, Center for System Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Peralta MA; Program in Membrane Biology, Center for System Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Gombar F; Program in Membrane Biology, Center for System Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Brown D; Program in Membrane Biology, Center for System Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Breton S; Program in Membrane Biology, Center for System Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
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Źródło :
The Journal of physiology [J Physiol] 2019 Apr; Vol. 597 (7), pp. 1957-1973. Date of Electronic Publication: 2019 Feb 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Purinergic Agents*
Adenosine/*pharmacology
Adenosine Triphosphate/*pharmacology
Epididymis/*physiology
Purinergic Agonists/*pharmacology
Vacuolar Proton-Translocating ATPases/*metabolism
Animals ; Epididymis/drug effects ; Gene Expression Regulation ; Hydrogen-Ion Concentration ; Male ; Mice ; Mice, Inbred C57BL ; Microscopy, Confocal ; Purinergic Antagonists/pharmacology ; Receptor, Adenosine A2B/genetics ; Receptor, Adenosine A2B/metabolism ; Receptors, Purinergic P2X4/genetics ; Receptors, Purinergic P2X4/metabolism ; Vacuolar Proton-Translocating ATPases/genetics
Czasopismo naukowe
Tytuł :
Lithocholic acid inhibits P2X2 and potentiates P2X4 receptor channel gating.
Autorzy :
Sivcev S; Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic; Faculty of Science, Charles University, Prague, Czech Republic.
Slavikova B; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.
Ivetic M; Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic; Faculty of Science, Charles University, Prague, Czech Republic.
Knezu M; Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic; Faculty of Science, Charles University, Prague, Czech Republic.
Kudova E; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.
Zemkova H; Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic. Electronic address: .
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2020 Sep; Vol. 202, pp. 105725. Date of Electronic Publication: 2020 Jul 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ion Channel Gating/*drug effects
Lithocholic Acid/*pharmacology
Purinergic P2X Receptor Agonists/*pharmacology
Purinergic P2X Receptor Antagonists/*pharmacology
Receptors, Purinergic P2X2/*physiology
Receptors, Purinergic P2X4/*physiology
Animals ; Female ; HEK293 Cells ; Humans ; Hypothalamus/cytology ; Hypothalamus/drug effects ; Hypothalamus/physiology ; Lithocholic Acid/analogs & derivatives ; Male ; Neurons/drug effects ; Neurons/physiology ; Pituitary Gland, Anterior/cytology ; Pituitary Gland, Anterior/drug effects ; Pituitary Gland, Anterior/physiology ; Rats, Wistar ; Receptors, Purinergic P2X7/physiology
Czasopismo naukowe
Tytuł :
P2 Receptors Influence hMSCs Differentiation towards Endothelial Cell and Smooth Muscle Cell Lineages.
Autorzy :
Zhang Y; Department of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, D-53359 Rheinbach, Germany.; Institute of Pharmaceutical & Medicinal Chemistry, University of Dusseldorf, D-40225 Dusseldorf, Germany.
Babczyk P; Department of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, D-53359 Rheinbach, Germany.
Pansky A; Department of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, D-53359 Rheinbach, Germany.
Kassack MU; Institute of Pharmaceutical & Medicinal Chemistry, University of Dusseldorf, D-40225 Dusseldorf, Germany.
Tobiasch E; Department of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, D-53359 Rheinbach, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Aug 27; Vol. 21 (17). Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Journal Article
MeSH Terms :
Endothelial Cells/*cytology
Mesenchymal Stem Cells/*cytology
Myocytes, Smooth Muscle/*cytology
Receptors, Purinergic P2/*metabolism
Cell Culture Techniques ; Cell Differentiation ; Cells, Cultured ; Endothelial Cells/metabolism ; Female ; Gene Expression Regulation ; Humans ; Lipectomy ; Mesenchymal Stem Cells/metabolism ; Myocytes, Smooth Muscle/metabolism ; Purinergic P2 Receptor Agonists/pharmacology ; Purinergic P2 Receptor Antagonists/pharmacology ; Receptors, Purinergic P2/genetics ; Receptors, Purinergic P2Y1/genetics ; Receptors, Purinergic P2Y1/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
[Risks of progression of cerebrovascular pathology associated with the activity of the brain purinergic system].
Autorzy :
Barinov EF; Gorky Donetsk National Medical University, Donetsk, Ukraina.
Statinova EA; Gorky Donetsk National Medical University, Donetsk, Ukraina.
Sokhina VS; Gorky Donetsk National Medical University, Donetsk, Ukraina.
Faber TI; Gorky Donetsk National Medical University, Donetsk, Ukraina.
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Transliterated Title :
Riski progressirovaniya tserebrovaskulyarnoi patologii, svyazannye s aktivnost'yu purinergicheskoi sistemy mozga.
Źródło :
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2020; Vol. 120 (10), pp. 118-124.
Typ publikacji :
Journal Article
MeSH Terms :
Adenosine Triphosphate*
Receptors, Purinergic P2*/metabolism
Brain/metabolism ; Neuroglia ; Receptors, Purinergic/metabolism
Czasopismo naukowe
Tytuł :
Entecavir as a P2X7R antagonist ameliorates platelet activation and thrombus formation.
Autorzy :
Ming Y; Laboratory of Ethnopharmacology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Xin G; Laboratory of Ethnopharmacology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Ji B; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pennsylvania, United States.
Ji C; Clinical Laboratory, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
Wei Z; Laboratory of Ethnopharmacology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Zhang B; Laboratory of Ethnopharmacology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Zhang J; Laboratory of Ethnopharmacology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Yu K; Laboratory of Ethnopharmacology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Zhang X; Laboratory of Ethnopharmacology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Li S; Laboratory of Ethnopharmacology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Li Y; Laboratory of Ethnopharmacology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Xing Z; Laboratory of Ethnopharmacology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Niu H; Laboratory of Ethnopharmacology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: .
Huang W; Laboratory of Ethnopharmacology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: .
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Źródło :
Journal of pharmacological sciences [J Pharmacol Sci] 2020 Sep; Vol. 144 (1), pp. 43-51. Date of Electronic Publication: 2020 Jul 03.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, Purinergic P2X7*
Guanine/*analogs & derivatives
Platelet Activation/*drug effects
Purinergic P2X Receptor Antagonists/*pharmacology
Purinergic P2X Receptor Antagonists/*therapeutic use
Thrombosis/*prevention & control
Animals ; Antioxidants ; Bleeding Time ; Blood Coagulation/drug effects ; Cytoprotection/drug effects ; Disease Models, Animal ; Guanine/pharmacology ; Guanine/therapeutic use ; Humans ; Lipid Peroxidation/drug effects ; Male ; Mice, Inbred C57BL ; Molecular Docking Simulation ; Platelet Aggregation/drug effects ; Thrombosis/blood
Czasopismo naukowe
Tytuł :
P2X7 receptors exert a permissive effect on the activation of presynaptic AMPA receptors in rat trigeminal caudal nucleus glutamatergic nerve terminals.
Autorzy :
Currò D; Institute of Pharmacology, School of Medicine, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168, Rome, Italy.
Navarra P; Institute of Pharmacology, School of Medicine, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168, Rome, Italy.
Samengo I; Institute of Pharmacology, School of Medicine, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168, Rome, Italy.
Martire M; Institute of Pharmacology, School of Medicine, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168, Rome, Italy. .
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Źródło :
The journal of headache and pain [J Headache Pain] 2020 Jul 02; Vol. 21 (1), pp. 83. Date of Electronic Publication: 2020 Jul 02.
Typ publikacji :
Journal Article
MeSH Terms :
Nerve Endings/*drug effects
Nerve Endings/*metabolism
Receptors, AMPA/*metabolism
Receptors, Presynaptic/*metabolism
Receptors, Purinergic P2X7/*physiology
Trigeminal Caudal Nucleus/*metabolism
Animals ; Excitatory Amino Acid Antagonists/pharmacology ; Male ; Purinergic P2X Receptor Agonists ; Purinergic P2X Receptor Antagonists/pharmacology ; Rats ; Synaptic Transmission ; Synaptosomes/drug effects ; Synaptosomes/metabolism
Czasopismo naukowe
Tytuł :
P2X7 Receptors: An Untapped Target for the Management of Cardiovascular Disease.
Autorzy :
Shokoples BG; Vascular and Hypertension Research Unit, Lady Davis Institute for Medical Research (B.G.S., P.P., E.L.S.), Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Paradis P; Vascular and Hypertension Research Unit, Lady Davis Institute for Medical Research (B.G.S., P.P., E.L.S.), Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Schiffrin EL; Vascular and Hypertension Research Unit, Lady Davis Institute for Medical Research (B.G.S., P.P., E.L.S.), Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.; Department of Medicine (E.L.S.), Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Jan; Vol. 41 (1), pp. 186-199. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Anti-Inflammatory Agents/*therapeutic use
Cardiovascular Agents/*therapeutic use
Cardiovascular Diseases/*drug therapy
Cardiovascular System/*drug effects
Purinergic P2X Receptor Antagonists/*therapeutic use
Receptors, Purinergic P2X7/*drug effects
Animals ; Anti-Inflammatory Agents/adverse effects ; Cardiovascular Agents/adverse effects ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/physiopathology ; Cardiovascular System/metabolism ; Cardiovascular System/pathology ; Humans ; Interleukin-18/metabolism ; Interleukin-1beta/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Purinergic P2X Receptor Antagonists/adverse effects ; Receptors, Purinergic P2X7/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
P2X7 Receptor Activity Limits Accumulation of T Cells within Tumors.
Autorzy :
Romagnani A; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland.
Rottoli E; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
Mazza EMC; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Rezzonico-Jost T; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland.
De Ponte Conti B; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
Proietti M; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland.
Perotti M; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland.; Institute for Microbiology, ETH Zürich, Zürich, Switzerland.
Civanelli E; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
Perruzza L; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland.
Catapano AL; Department of Excellence in Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.; IRCSS Multimedica, Milan, Italy.
Baragetti A; Department of Excellence in Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
Tenedini E; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.
Tagliafico E; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.
Falzoni S; Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara, Italy.
Di Virgilio F; Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara, Italy.
Norata GD; Department of Excellence in Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
Bicciato S; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Grassi F; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland. .; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.; Istituto Nazionale Genetica Molecolare 'Romeo ed Enrica Invernizzi,' Milan, Italy.
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Źródło :
Cancer research [Cancer Res] 2020 Sep 15; Vol. 80 (18), pp. 3906-3919. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Migration Inhibition*
Cellular Senescence/*immunology
Lymphocytes, Tumor-Infiltrating/*immunology
Lymphocytes, Tumor-Infiltrating/*metabolism
Melanoma, Experimental/*immunology
Receptors, Purinergic P2X7/*metabolism
Adenosine Triphosphate/metabolism ; Animals ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Cycle ; Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Flow Cytometry/methods ; Gene Expression Profiling ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy, Adoptive/methods ; Melanoma, Experimental/pathology ; Melanoma, Experimental/therapy ; Mice ; Mice, Inbred C57BL ; Mitochondria/metabolism ; Neoplasm Transplantation ; Purinergic P2X Receptor Antagonists ; Reactive Oxygen Species/metabolism ; Receptors, Purinergic P2X7/deficiency ; T-Lymphocytes, Cytotoxic/immunology ; Transcription, Genetic ; Tumor Microenvironment/immunology ; Up-Regulation
Czasopismo naukowe
Tytuł :
Expanding Role of Dopaminergic Inhibition in Hypercapnic Responses of Cultured Rat Carotid Body Cells: Involvement of Type II Glial Cells.
Autorzy :
Leonard EM; Department of Biology, McMaster University, 1280 Main St. West, Hamilton, ON L8S 4K1, Canada.
Nurse CA; Department of Biology, McMaster University, 1280 Main St. West, Hamilton, ON L8S 4K1, Canada.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jul 30; Vol. 21 (15). Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article
MeSH Terms :
Carotid Body/*metabolism
Dopamine/*metabolism
Receptors, Dopamine D2/*genetics
Receptors, Purinergic P2Y2/*genetics
Adenosine Triphosphate/metabolism ; Animals ; Calcium/metabolism ; Calcium Signaling/drug effects ; Carbon Dioxide/metabolism ; Carotid Body/drug effects ; Carotid Body/growth & development ; Homeostasis/genetics ; Hydrogen/metabolism ; Oxygen/metabolism ; Purinergic P2Y Receptor Agonists/pharmacology ; Rats ; Signal Transduction/drug effects ; Sulpiride/pharmacology ; Uridine Triphosphate/pharmacology
Czasopismo naukowe

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