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Tytuł:
Janus kinase inhibitors ruxolitinib and baricitinib impair glycoprotein-VI mediated platelet function.
Autorzy:
Parra-Izquierdo I; Knight Cardiovascular Institute and Division of Cardiology, Oregon Health & Science University, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.
Melrose AR; Knight Cardiovascular Institute and Division of Cardiology, Oregon Health & Science University, Portland, OR, USA.
Pang J; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.
Lakshmanan HHS; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.
Reitsma SE; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.
Vavilapalli SH; Knight Cardiovascular Institute and Division of Cardiology, Oregon Health & Science University, Portland, OR, USA.
Larson MK; Biology Department, Augustana University, Sioux Falls, SD, USA.
Shatzel JJ; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.; Division of Hematology and Medical Oncology, School of Medicine, Oregon Health & Science University, Portland, OR, USA.
McCarty OJT; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.; Division of Hematology and Medical Oncology, School of Medicine, Oregon Health & Science University, Portland, OR, USA.
Aslan JE; Knight Cardiovascular Institute and Division of Cardiology, Oregon Health & Science University, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, USA.
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Źródło:
Platelets [Platelets] 2022 Apr 03; Vol. 33 (3), pp. 404-415. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji:
Journal Article
MeSH Terms:
Azetidines/*therapeutic use
Blood Platelets/*metabolism
Janus Kinase Inhibitors/*therapeutic use
Nitriles/*therapeutic use
Platelet Activation/*drug effects
Platelet Adhesiveness/*drug effects
Platelet Membrane Glycoproteins/*drug effects
Purines/*therapeutic use
Pyrazoles/*therapeutic use
Pyrimidines/*therapeutic use
Sulfonamides/*therapeutic use
Azetidines/pharmacology ; Humans ; Janus Kinase Inhibitors/pharmacology ; Nitriles/pharmacology ; Platelet Membrane Glycoproteins/metabolism ; Purines/pharmacology ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; Sulfonamides/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Factors affecting drug retention of Janus kinase inhibitors in patients with rheumatoid arthritis: the ANSWER cohort study.
Autorzy:
Ebina K; Department of Musculoskeletal Regenerative Medicine, Osaka University Graduate School of Medicine, Osaka, Japan. .
Hirano T; Department of Rheumatology, Nishinomiya Municipal Hospital, Hyogo, Japan.
Maeda Y; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan.
Yamamoto W; Department of Health Information Management, Kurashiki Sweet Hospital, Okayama, Japan.; Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hashimoto M; Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Clinical Immunology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Murata K; Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Onishi A; Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Jinno S; Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Hyogo, Japan.
Hara R; Department of Orthopaedic Surgery, Nara Medical University, Nara, Japan.
Son Y; First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Amuro H; First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Takeuchi T; Department of Internal Medicine (IV), Osaka Medical and Pharmaceutical University, Osaka, Japan.
Yoshikawa A; Department of Internal Medicine (IV), Osaka Medical and Pharmaceutical University, Osaka, Japan.
Katayama M; Department of Rheumatology, Osaka Red Cross Hospital, Osaka, Japan.
Yamamoto K; Information Technology Center, Wakayama Medical University, Wakayama, Japan.
Okita Y; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.
Hirao M; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Etani Y; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Kumanogoh A; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan.
Okada S; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Nakata K; Department of Health and Sport Sciences, Osaka University Graduate School of Medicine, Osaka, Japan.
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Źródło:
Scientific reports [Sci Rep] 2022 Jan 07; Vol. 12 (1), pp. 134. Date of Electronic Publication: 2022 Jan 07.
Typ publikacji:
Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Antirheumatic Agents/*therapeutic use
Arthritis, Rheumatoid/*drug therapy
Azetidines/*therapeutic use
Janus Kinase Inhibitors/*therapeutic use
Piperidines/*therapeutic use
Purines/*therapeutic use
Pyrazoles/*therapeutic use
Pyrimidines/*therapeutic use
Sulfonamides/*therapeutic use
Age Factors ; Aged ; Antirheumatic Agents/adverse effects ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/enzymology ; Azetidines/adverse effects ; Drug-Related Side Effects and Adverse Reactions/etiology ; Female ; Humans ; Janus Kinase Inhibitors/adverse effects ; Japan ; Male ; Middle Aged ; Piperidines/adverse effects ; Purines/adverse effects ; Pyrazoles/adverse effects ; Pyrimidines/adverse effects ; Registries ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Sex Factors ; Sulfonamides/adverse effects ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ribociclib enhances infigratinib-induced cancer cell differentiation and delays resistance in FGFR-driven hepatocellular carcinoma.
Autorzy:
Prawira A; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore.
Le TBU; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore.
Vu TC; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore.
Huynh H; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore.
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2021 Mar; Vol. 41 (3), pp. 608-620. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aminopyridines*/pharmacology
Carcinoma, Hepatocellular*/drug therapy
Liver Neoplasms*/drug therapy
Phenylurea Compounds*/pharmacology
Purines*/pharmacology
Pyrimidines*/pharmacology
Animals ; Cell Differentiation ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Male ; Mice ; Mice, SCID ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tofacitinib and Baricitinib Are Taken up by Different Uptake Mechanisms Determining the Efficacy of Both Drugs in RA.
Autorzy:
Amrhein J; Experimental Nephrology, Department of Internal Medicine D, University Hospital Münster, 48149 Münster, Germany.
Drynda S; Department of Orthopedic Surgery, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Schlatt L; Institute of Inorganic and Analytical Chemistry, University of Münster, 48149 Münster, Germany.
Karst U; Institute of Inorganic and Analytical Chemistry, University of Münster, 48149 Münster, Germany.
Lohmann CH; Department of Orthopedic Surgery, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Ciarimboli G; Experimental Nephrology, Department of Internal Medicine D, University Hospital Münster, 48149 Münster, Germany.
Bertrand J; Department of Orthopedic Surgery, Otto-von-Guericke University, 39120 Magdeburg, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 10; Vol. 21 (18). Date of Electronic Publication: 2020 Sep 10.
Typ publikacji:
Journal Article
MeSH Terms:
Antirheumatic Agents/*pharmacokinetics
Arthritis, Rheumatoid/*drug therapy
Azetidines/*pharmacokinetics
Piperidines/*pharmacokinetics
Purines/*pharmacokinetics
Pyrazoles/*pharmacokinetics
Pyrimidines/*pharmacokinetics
Sulfonamides/*pharmacokinetics
Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/metabolism ; Azetidines/therapeutic use ; Drug Evaluation, Preclinical ; Fibroblasts/metabolism ; HEK293 Cells ; Humans ; Janus Kinase 1/antagonists & inhibitors ; Organic Cation Transport Proteins/metabolism ; Phosphorylation/drug effects ; Piperidines/therapeutic use ; Primary Cell Culture ; Purines/therapeutic use ; Pyrazoles/therapeutic use ; Pyrimidines/therapeutic use ; STAT3 Transcription Factor/metabolism ; Sulfonamides/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparative efficacy and safety of tofacitinib, baricitinib, upadacitinib, filgotinib and peficitinib as monotherapy for active rheumatoid arthritis.
Autorzy:
Ho Lee Y; Department of Internal Medicine, Division of Rheumatology, Korea University College of Medicine, Seoul, Korea.
Gyu Song G; Department of Internal Medicine, Division of Rheumatology, Korea University College of Medicine, Seoul, Korea.
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Źródło:
Journal of clinical pharmacy and therapeutics [J Clin Pharm Ther] 2020 Aug; Vol. 45 (4), pp. 674-681. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji:
Comparative Study; Journal Article; Meta-Analysis
MeSH Terms:
Adamantane/*analogs & derivatives
Antirheumatic Agents/*therapeutic use
Arthritis, Rheumatoid/*drug therapy
Azetidines/*therapeutic use
Heterocyclic Compounds, 3-Ring/*therapeutic use
Niacinamide/*analogs & derivatives
Piperidines/*therapeutic use
Purines/*therapeutic use
Pyrazoles/*therapeutic use
Pyridines/*therapeutic use
Pyrimidines/*therapeutic use
Sulfonamides/*therapeutic use
Triazoles/*therapeutic use
Adamantane/therapeutic use ; Bayes Theorem ; Humans ; Niacinamide/therapeutic use ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Recent updates on purine and pyrimidine metabolism in physiological and pathological settings.
Autorzy:
Jordheim LP; Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Univ Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Peters GJ; Laboratory of Medical Oncology, Amsterdam UMC, VUMC, Amsterdam, the Netherlands.
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Źródło:
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2020; Vol. 39 (10-12), pp. 1273-1280. Date of Electronic Publication: 2020 Mar 17.
Typ publikacji:
Congress
MeSH Terms:
Purines/*metabolism
Pyrimidines/*metabolism
Disease ; Humans
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Metabolic basis of neuronal vulnerability to ischemia; an in vivo untargeted metabolomics approach.
Autorzy:
Rashad S; Department of Neurosurgical Engineering and Translational Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan. .; Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan. .
Saigusa D; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Sendai, Japan.; Medical Biochemistry, Tohoku University School of Medicine, Sendai, Japan.
Yamazaki T; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Matsumoto Y; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Tomioka Y; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Saito R; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Sendai, Japan.; Medical Biochemistry, Tohoku University School of Medicine, Sendai, Japan.
Uruno A; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Sendai, Japan.; Medical Biochemistry, Tohoku University School of Medicine, Sendai, Japan.
Niizuma K; Department of Neurosurgical Engineering and Translational Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan. .; Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan. .; Department of Neurosurgical Engineering and Translational Neuroscience, Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan. .
Yamamoto M; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Sendai, Japan.; Medical Biochemistry, Tohoku University School of Medicine, Sendai, Japan.
Tominaga T; Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
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Źródło:
Scientific reports [Sci Rep] 2020 Apr 16; Vol. 10 (1), pp. 6507. Date of Electronic Publication: 2020 Apr 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain Ischemia/*metabolism
Ischemic Attack, Transient/*genetics
Neurons/*metabolism
Purines/*metabolism
Pyrimidines/*metabolism
Animals ; Apoptosis/genetics ; Brain Ischemia/pathology ; CA1 Region, Hippocampal/metabolism ; CA1 Region, Hippocampal/pathology ; CA3 Region, Hippocampal/metabolism ; Chromatography, Liquid ; Gene Expression Regulation/genetics ; Humans ; Ischemic Attack, Transient/metabolism ; Ischemic Attack, Transient/pathology ; Mass Spectrometry ; Metabolomics/methods ; Neurons/pathology ; Rats ; Signal Transduction/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Codon Directional Asymmetry Suggests Swapped Prebiotic 1st and 2nd Codon Positions.
Autorzy:
Seligmann H; The National Natural History Collections, The Hebrew University of Jerusalem, 91404 Jerusalem, Israel.; Faculty of Medicine, Université Grenoble Alpes, Laboratory AGEIS EA 7407, Team Tools for e-Gnosis Medical, F-38700 La Tronche, France.
Demongeot J; Faculty of Medicine, Université Grenoble Alpes, Laboratory AGEIS EA 7407, Team Tools for e-Gnosis Medical, F-38700 La Tronche, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 05; Vol. 21 (1). Date of Electronic Publication: 2020 Jan 05.
Typ publikacji:
Journal Article
MeSH Terms:
Codon*
Amino Acids/*genetics
Amino Acyl-tRNA Synthetases/*metabolism
Purines/*chemistry
Pyrimidines/*chemistry
Amino Acids/chemistry ; Evolution, Molecular ; Genetic Code ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Models, Genetic ; Nucleotides/chemistry ; Protein Biosynthesis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Advancement in the development of heterocyclic nucleosides for the treatment of cancer - A review.
Autorzy:
Mirza AZ; Chemistry Department, Faculty of Applied Sciences, Umm Al-Qura University , Makkah , Saudi Arabia.; Research Laboratories Centre, Faculty of Applied Sciences, Umm Al-Qura University , Makkah , Saudi Arabia.
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Źródło:
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2019; Vol. 38 (11), pp. 836-857. Date of Electronic Publication: 2019 May 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Antineoplastic Agents/*pharmacology
Nucleosides/*pharmacology
Purines/*chemistry
Pyrimidines/*chemistry
Antineoplastic Agents/chemistry ; Dioxolanes/chemistry ; Drug Approval ; Drug Screening Assays, Antitumor ; Humans ; Models, Molecular ; Molecular Structure ; Nucleosides/chemistry ; Quantitative Structure-Activity Relationship ; United States ; United States Food and Drug Administration
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Purine and pyrimidine salvage pathway in thermophiles: a valuable source of biocatalysts for the industrial production of nucleic acid derivatives.
Autorzy:
Del Arco J; Applied Biotechnology Group, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Urbanización El Bosque, c/ Tajo, s/n, E-28670, Villaviciosa de Odón, Madrid, Spain.
Fernández-Lucas J; Applied Biotechnology Group, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Urbanización El Bosque, c/ Tajo, s/n, E-28670, Villaviciosa de Odón, Madrid, Spain. .; Grupo de Investigación en Desarrollo Agroindustrial Sostenible, Universidad de la Costa, CUC, Calle 58 #55-66, Barranquilla, Colombia. .
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Źródło:
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2018 Sep; Vol. 102 (18), pp. 7805-7820. Date of Electronic Publication: 2018 Jul 19.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Enzymes/*chemistry
Nucleic Acids/*chemistry
Purines/*chemistry
Pyrimidines/*chemistry
Biocatalysis ; Enzyme Stability ; Hot Temperature
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ibrutinib and idelalisib block immunophenotypic changes associated with the adhesion and activation of CLL cells in the tumor microenvironment.
Autorzy:
Shen Y; a School of Life and Environmental Sciences , University of Sydney , Sydney , Australia.
Best OG; b Northern Blood Research Centre , Kolling Institute of Medical Research , St Leonards , Australia.
Mulligan SP; b Northern Blood Research Centre , Kolling Institute of Medical Research , St Leonards , Australia.
Christopherson RI; a School of Life and Environmental Sciences , University of Sydney , Sydney , Australia.
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Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2018 Aug; Vol. 59 (8), pp. 1927-1937. Date of Electronic Publication: 2017 Nov 22.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Adhesion/*drug effects
Lymphocyte Activation/*drug effects
Purines/*pharmacology
Pyrazoles/*pharmacology
Pyrimidines/*pharmacology
Quinazolinones/*pharmacology
Tumor Microenvironment/*drug effects
Adenine/analogs & derivatives ; Animals ; Antigens, CD/immunology ; Antigens, CD/metabolism ; Cell Adhesion/immunology ; Coculture Techniques ; Fibroblasts/drug effects ; Fibroblasts/immunology ; Fibroblasts/metabolism ; Humans ; Immunophenotyping ; L Cells ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Lymphocyte Activation/immunology ; Mice ; Piperidines ; Tumor Cells, Cultured ; Tumor Microenvironment/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Correlation between polar surface area and bioferroelectricity in DNA and RNA nucleobases.
Autorzy:
Yam SC; Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Zain SM; Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Sanghiran Lee V; Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Chew KH; Department of Physics, Centre for Theoretical and Computational Physics, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia. .
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Źródło:
The European physical journal. E, Soft matter [Eur Phys J E Soft Matter] 2018 Jul 18; Vol. 41 (7), pp. 86. Date of Electronic Publication: 2018 Jul 18.
Typ publikacji:
Journal Article
MeSH Terms:
Electricity*
DNA/*chemistry
Purines/*chemistry
Pyrimidines/*chemistry
RNA/*chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Are Janus Kinase Inhibitors Superior over Classic Biologic Agents in RA Patients?
Autorzy:
Kotyla PJ; Department of Internal Medicine and Rheumatology, Medical Faculty in Katowice, Medical University of Silesia, Katowice, Poland.
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Źródło:
BioMed research international [Biomed Res Int] 2018 May 10; Vol. 2018, pp. 7492904. Date of Electronic Publication: 2018 May 10 (Print Publication: 2018).
Typ publikacji:
Journal Article; Review
MeSH Terms:
Azetidines/*therapeutic use
Janus Kinases/*antagonists & inhibitors
Piperidines/*therapeutic use
Protein Kinase Inhibitors/*therapeutic use
Pyrimidines/*therapeutic use
Pyrroles/*therapeutic use
Rheumatic Fever/*drug therapy
Rheumatic Fever/*enzymology
Sulfonamides/*therapeutic use
Animals ; Humans ; Janus Kinases/metabolism ; Purines ; Pyrazoles
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Optimization of High Performance Liquid Chromatography Method for Simultaneous Determination of Some Purine and Pyrimidine Bases.
Autorzy:
Markelj J
Zupančič T
Pihlar B
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Źródło:
Acta chimica Slovenica [Acta Chim Slov] 2016; Vol. 63 (1), pp. 8-17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chromatography, High Pressure Liquid/*methods
Purines/*analysis
Pyrimidines/*analysis
Hydrogen-Ion Concentration ; Purines/chemistry ; Pyrimidines/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Targeting neoplastic B cells and harnessing microenvironment: the "double face" of ibrutinib and idelalisib.
Autorzy:
Maffei R; Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Via Del Pozzo 71, 41124, Modena, Italy. .
Fiorcari S; Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Via Del Pozzo 71, 41124, Modena, Italy. .
Martinelli S; Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Via Del Pozzo 71, 41124, Modena, Italy. .
Potenza L; Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Via Del Pozzo 71, 41124, Modena, Italy. .
Luppi M; Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Via Del Pozzo 71, 41124, Modena, Italy. .
Marasca R; Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Via Del Pozzo 71, 41124, Modena, Italy. .
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Źródło:
Journal of hematology & oncology [J Hematol Oncol] 2015 May 29; Vol. 8, pp. 60. Date of Electronic Publication: 2015 May 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Antineoplastic Agents/*therapeutic use
Purines/*therapeutic use
Pyrazoles/*therapeutic use
Pyrimidines/*therapeutic use
Quinazolinones/*therapeutic use
Adenine/analogs & derivatives ; Antineoplastic Agents/administration & dosage ; Humans ; Killer Cells, Natural ; Piperidines ; Protein Kinase Inhibitors/therapeutic use ; Purines/administration & dosage ; Pyrazoles/administration & dosage ; Pyrimidines/administration & dosage ; Quinazolinones/administration & dosage ; Signal Transduction ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A facile synthesis of novel pyrazolopyrimidine thioglycosides as purine thioglycoside analogues.
Autorzy:
Abu-Zaied MA; a Green Chemistry Department , National Research Centre , Dokki , Giza , Egypt.
Elgemeie GH; b Chemistry Department, Faculty of Science , Helwan University , Helwan , Cairo , Egypt.
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Źródło:
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2018 Jan 02; Vol. 37 (1), pp. 67-77. Date of Electronic Publication: 2018 Jan 16.
Typ publikacji:
Journal Article
MeSH Terms:
Pyrimidines/*chemical synthesis
Thioglycosides/*chemical synthesis
Carbohydrates/chemistry ; Magnetic Resonance Spectroscopy/methods ; Molecular Structure ; Purines/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Novel developments in metabolic disorders of purine and pyrimidine metabolism and therapeutic applications of their analogs.
Autorzy:
Torres RJ; a Divisions of Internal Medicine and Clinical Biochemistry, Unidad Metabólico-Vascular, Edificio de Consultas Externas, Planta SEMISÓTANO , Hospital Universitario 'La Paz' , Paseo de la Castellana 261, 28046 Madrid , Spain.
Peters GJ
Puig JG
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Źródło:
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2014; Vol. 33 (4-6), pp. 165-73.
Typ publikacji:
Introductory Journal Article
MeSH Terms:
Purine-Pyrimidine Metabolism, Inborn Errors/*drug therapy
Purine-Pyrimidine Metabolism, Inborn Errors/*metabolism
Purines/*metabolism
Purines/*therapeutic use
Pyrimidines/*metabolism
Pyrimidines/*therapeutic use
Awards and Prizes ; Humans ; Purines/chemistry ; Pyrimidines/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A new route for the prebiotic synthesis of nucleobases and hydantoins in water/ice solutions involving the photochemistry of acetylene.
Autorzy:
Menor-Salván C; Centro de Astrobiología (CSIC-INTA), Ctra. Torrejón-Ajalvir km. 4, 28850 Torrejón de Ardoz, Spain. />Marín-Yaseli MR
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Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2013 May 10; Vol. 19 (20), pp. 6488-97. Date of Electronic Publication: 2013 Mar 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetylene/*chemistry
Hydantoins/*chemical synthesis
Purines/*chemical synthesis
Pyrimidines/*chemical synthesis
Urea/*chemistry
Water/*chemistry
Acetylene/radiation effects ; Hydantoins/chemistry ; Ice/analysis ; Molecular Structure ; Nitrogen/chemistry ; Oxidation-Reduction ; Photochemistry ; Prebiotics ; Purines/chemistry ; Pyrimidines/chemistry ; Uracil/chemical synthesis ; Uric Acid/chemical synthesis ; Uric Acid/chemistry
Czasopismo naukowe
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Wyświetlanie 1-20 z 809

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