Cellograph: a semi-supervised approach to analyzing multi-condition single-cell RNA-sequencing data using graph neural networks.
Autorzy:
Shahir JA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Stanley N; Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. PurvisJE; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. .; Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. .; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. .; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. .
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Źródło:
BMC bioinformatics [BMC Bioinformatics] 2024 Jan 15; Vol. 25 (1), pp. 25. Date of Electronic Publication: 2024 Jan 15.
MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.
Autorzy:
Cho MG; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Kumar RJ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; UNC MD-PhD Program, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. Lin CC; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Boyer JA; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Shahir JA; Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Fagan-Solis K; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Simpson DA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Fan C; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Foster CE; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Goddard AM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Lerner LM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Ellington SW; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Wang Q; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Wang Y; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Ho AY; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA. Liu P; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Perou CM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Zhang Q; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. McGinty RK; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. PurvisJE; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Gupta GP; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. gaorav_.; UNC MD-PhD Program, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. gaorav_.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. gaorav_.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. gaorav_.; Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. gaorav_.
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Źródło:
Nature [Nature] 2024 Jan; Vol. 625 (7995), pp. 585-592. Date of Electronic Publication: 2024 Jan 10.
Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation.
Autorzy:
Adler FR; Department of Mathematics, University of Utah, Salt Lake City, UT 84112, USA; School of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA. Anderson ARA; Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Bhushan A; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL 60616, USA. Bogdan P; Ming Hsieh Department of Electrical and Computer Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, USA. Bravo-Cordero JJ; Division of Hematology and Oncology, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Brock A; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA. Chen Y; Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA. Cukierman E; Cancer Signaling and Microenvironment Program, Marvin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Philadelphia, PA 19111, USA; Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA. DelGiorno KE; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA. Denis GV; Boston University-Boston Medical Center Cancer Center, Boston University School of Medicine, Boston, MA 02118, USA. Ferrall-Fairbanks MC; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA; University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32611, USA. Gartner ZJ; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA; NSF Center for Cellular Construction, San Francisco, CA 94158, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA. Germain RN; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Gordon DM; Department of Biology, Stanford University, Stanford, CA 94305, USA. Hunter G; Department of Biology, Clarkson University, Potsdam, NY 13699, USA. Jolly MK; Centre for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, 560012, India. Karacosta LG; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Mythreye K; Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA; O'Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA. Katira P; Mechanical Engineering Department, San Diego State University, San Diego, CA 92182, USA; Computational Sciences Research Center, San Diego State University, San Diego, CA 92182, USA. Kulkarni RP; Department of Dermatology, Oregon Health and Science University, Portland, OR 97239, USA; Department Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA; Department Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA; Operative Care Division, VA Portland Health Care System, Portland, OR 97239, USA. Kutys ML; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA. Lander AD; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA. Laughney AM; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA. Levine H; Center for Theoretical Biological Physics, Northeastern University, Boston, MA 02115, USA. Lou E; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. Lowenstein PR; Department of Neurosurgery, Rogel Cancer Center, The University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, Rogel Cancer Center, The University of Michigan, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, The University of Michigan, Ann Arbor, MI 48109, USA. Masters KS; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA. Pe'er D; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Peyton SR; Department of Chemical Engineering, University of Massachusetts, Amherst, MA 01003, USA. Platt MO; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30322, USA; Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Emory University, Atlanta, GA 30322, USA. PurvisJE; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Quon G; Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USA. Richer JK; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Cancer Center, Aurora, CO 80045, USA. Riddle NC; Department of Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA. Rodriguez A; Department of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. Snyder JC; Department of Surgery, Duke University, Durham, NC 27710, USA; Department of Cell Biology, Duke University, Durham, NC 27710, USA. Lee Szeto G; Allen Institute for Immunology, Seattle, WA 98109, USA; Seagen, Bothell, WA 98021, USA. Tomlin CJ; Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA 94720, USA. Yanai I; Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA; Institute for Computational Medicine, NYU Langone Health, New York, NY 10016, USA. Zervantonakis IK; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15232, USA; Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA. Dueck H; Division of Cancer Biology, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA. Electronic address: .
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Źródło:
Cell systems [Cell Syst] 2023 Apr 19; Vol. 14 (4), pp. 252-257.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
The consequences of differential origin licensing dynamics in distinct chromatin environments.
Autorzy:
Mei L; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Kedziora KM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Bioinformatics and Analytics Research Collaborative (BARC), University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Song EA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. PurvisJE; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Cook JG; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Integrating temporal single-cell gene expression modalities for trajectory inference and disease prediction.
Autorzy:
Ranek JS; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, USA.; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, USA. Stanley N; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, USA. .; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, USA. . PurvisJE; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, USA. .; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, USA. .
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Źródło:
Genome biology [Genome Biol] 2022 Sep 05; Vol. 23 (1), pp. 186. Date of Electronic Publication: 2022 Sep 05.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Stallaert W; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Taylor SR; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Kedziora KM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Bioinformatics and Analytics Research Collaborative (BARC), University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Taylor CD; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Sobon HK; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Young CL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Limas JC; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Varblow Holloway J; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Johnson MS; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Cook JG; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. PurvisJE; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Stallaert W; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Kedziora KM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Bioinformatics and Analytics Research Collaborative, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Taylor CD; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Zikry TM; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA. Ranek JS; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Sobon HK; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Taylor SR; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Young CL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Cook JG; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. PurvisJE; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: .
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Źródło:
Cell systems [Cell Syst] 2022 Mar 16; Vol. 13 (3), pp. 230-240.e3. Date of Electronic Publication: 2021 Nov 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
A Proximal-to-Distal Survey of Healthy Adult Human Small Intestine and Colon Epithelium by Single-Cell Transcriptomics.
Autorzy:
Burclaff J; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Bliton RJ; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill/North Carolina State University, Chapel Hill, North Carolina. Breau KA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Ok MT; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill/North Carolina State University, Chapel Hill, North Carolina. Gomez-Martinez I; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Ranek JS; Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Bhatt AP; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. PurvisJE; Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Woosley JT; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Magness ST; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill/North Carolina State University, Chapel Hill, North Carolina; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address: .
Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2.
Autorzy:
Enrico TP; Department of Pharmacology. The University of North Carolina at Chapel Hill, Chapel Hill, United States.; Lineberger Comprehensive Cancer Center. The University of North Carolina at Chapel Hill, Chapel Hill, United States. Stallaert W; Department of Genetics. The University of North Carolina at Chapel Hill, Chapel Hill, United States. Wick ET; Department of Pharmacology. The University of North Carolina at Chapel Hill, Chapel Hill, United States.; Lineberger Comprehensive Cancer Center. The University of North Carolina at Chapel Hill, Chapel Hill, United States. Ngoi P; Department of Chemistry and Biochemistry. University of California at Santa Cruz, Santa Cruz, United States. Wang X; Lineberger Comprehensive Cancer Center. The University of North Carolina at Chapel Hill, Chapel Hill, United States. Rubin SM; Department of Chemistry and Biochemistry. University of California at Santa Cruz, Santa Cruz, United States. Brown NG; Department of Pharmacology. The University of North Carolina at Chapel Hill, Chapel Hill, United States.; Lineberger Comprehensive Cancer Center. The University of North Carolina at Chapel Hill, Chapel Hill, United States. PurvisJE; Lineberger Comprehensive Cancer Center. The University of North Carolina at Chapel Hill, Chapel Hill, United States.; Department of Genetics. The University of North Carolina at Chapel Hill, Chapel Hill, United States. Emanuele MJ; Department of Pharmacology. The University of North Carolina at Chapel Hill, Chapel Hill, United States.; Lineberger Comprehensive Cancer Center. The University of North Carolina at Chapel Hill, Chapel Hill, United States.
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Źródło:
ELife [Elife] 2021 Dec 01; Vol. 10. Date of Electronic Publication: 2021 Dec 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Inferring the structures of signaling motifs from paired dynamic traces of single cells.
Autorzy:
Haggerty RA; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Computational Medicine Program, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Curriculum for Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America. PurvisJE; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Computational Medicine Program, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Curriculum for Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2021 Feb 04; Vol. 17 (2), pp. e1008657. Date of Electronic Publication: 2021 Feb 04 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency.
Autorzy:
Kumar RJ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Chao HX; Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Simpson DA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Feng W; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Cho MG; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Roberts VR; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Sullivan AR; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Shah SJ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Wozny AS; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Fagan-Solis K; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Kumar S; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Luthman A; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Ramsden DA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. PurvisJE; Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Gupta GP; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
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Źródło:
NAR cancer [NAR Cancer] 2020 Dec; Vol. 2 (4), pp. zcaa038. Date of Electronic Publication: 2020 Dec 21.
Autophagy regulates the localization and degradation of p16 .
Autorzy:
Coryell PR; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Goraya SK; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Griffin KA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Redick MA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Sisk SR; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. PurvisJE; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Curriculum for Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
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Źródło:
Aging cell [Aging Cell] 2020 Jul; Vol. 19 (7), pp. e13171. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Bistable switches as integrators and actuators during cell cycle progression.
Autorzy:
Stallaert W; Department of Genetics, Computational Medicine Program, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA. Kedziora KM; Department of Genetics, Computational Medicine Program, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA. Chao HX; Department of Genetics, Computational Medicine Program, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA. PurvisJE; Department of Genetics, Computational Medicine Program, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
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Źródło:
FEBS letters [FEBS Lett] 2019 Oct; Vol. 593 (20), pp. 2805-2816. Date of Electronic Publication: 2019 Oct 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
Genetic determinants of cellular addiction to DNA polymerase theta.
Autorzy:
Feng W; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Simpson DA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Carvajal-Garcia J; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Price BA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Kumar RJ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Mose LE; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Wood RD; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville, TX, 78957, USA. Rashid N; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. PurvisJE; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Parker JS; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Ramsden DA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Gupta GP; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. .; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. .; Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. .
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Źródło:
Nature communications [Nat Commun] 2019 Sep 19; Vol. 10 (1), pp. 4286. Date of Electronic Publication: 2019 Sep 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Chemical screen for epigenetic barriers to single allele activation of Oct4.
Autorzy:
Headley KM; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, Chapel Hill, NC 27599, United States of America; Curriculum for Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, United States of America. Kedziora KM; Department of Genetics, Curriculum for Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States of America. Alejo A; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, Chapel Hill, NC 27599, United States of America. Lai EZ; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, Chapel Hill, NC 27599, United States of America. PurvisJE; Curriculum for Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, United States of America; Department of Genetics, Curriculum for Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina, 120 Mason Farm Road, Chapel Hill, NC 27599, United States of America. Hathaway NA; Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, Chapel Hill, NC 27599, United States of America; Curriculum for Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina, 120 Mason Farm Road, Chapel Hill, NC 27599, United States of America. Electronic address: .
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Źródło:
Stem cell research [Stem Cell Res] 2019 Jul; Vol. 38, pp. 101470. Date of Electronic Publication: 2019 May 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Wolff SC; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599-7264, USA. jeremy_purvis@med.unc.edu . PurvisJE; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599-7264, USA. jeremy_purvis@med.unc.edu .
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