- Tytuł:
- Comparative QSAR model generation using pyrazole derivatives for screening Janus kinase-1 inhibitors.
- Autorzy:
- Źródło:
- Chemical biology & drug design [Chem Biol Drug Des] 2020 May; Vol. 95 (5), pp. 503-519. Date of Electronic Publication: 2020 Mar 29.
- Typ publikacji:
- Journal Article
- MeSH Terms:
-
Quantitative Structure-Activity Relationship*
Janus Kinase 1/*antagonists & inhibitors
Protein Kinase Inhibitors/*chemistry
Pyrazoles/*chemistry
Asthma/drug therapy ; Asthma/pathology ; Binding Sites ; Humans ; Hydrophobic and Hydrophilic Interactions ; Inhibitory Concentration 50 ; Interleukin-4/metabolism ; Janus Kinase 1/metabolism ; Janus Kinase 2/antagonists & inhibitors ; Janus Kinase 2/metabolism ; Molecular Docking Simulation ; Nitriles ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Pyrazoles/metabolism ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use ; Pyrimidines ; STAT Transcription Factors ; Signal Transduction/drug effects
Czasopismo naukowe