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Wyszukujesz frazę ""Pyrazoles"" wg kryterium: Temat


Tytuł :
Identification of a new class of potent aldose reductase inhibitors: Design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines.
Autorzy :
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey. Electronic address: .
Demir Y; Department of Pharmacy Services, Nihat Delibalta Göle Vocational High School, Ardahan University, 75700, Ardahan, Turkey.
Yılmaz N; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.
Akalın Çiftçi G; Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.
Beydemir Ş; Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey; The Rectorate of Bilecik Şeyh Edebali University, 11230, Bilecik, Turkey.
Özdemir A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Aug 25; Vol. 345, pp. 109576. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Computer Simulation*
Drug Design*
Microwaves*
Aldehyde Reductase/*antagonists & inhibitors
Pyrazoles/*chemical synthesis
Pyrazoles/*pharmacology
Aldehyde Reductase/chemistry ; Aldehyde Reductase/metabolism ; Chemistry Techniques, Synthetic ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/pharmacology ; Molecular Docking Simulation ; Protein Conformation ; Pyrazoles/chemistry ; Pyrazoles/metabolism
Czasopismo naukowe
Tytuł :
Diazophosphonates: Effective Surrogates for Diazoalkanes in Pyrazole Synthesis.
Autorzy :
Ruffell K; School of Chemistry, University of Nottingham University Park, Nottingham, NG7 2RD, U.K.
Smith FR; School of Chemistry, University of Nottingham University Park, Nottingham, NG7 2RD, U.K.
Green MT; School of Chemistry, University of Nottingham University Park, Nottingham, NG7 2RD, U.K.
Nicolle SM; School of Chemistry, University of Nottingham University Park, Nottingham, NG7 2RD, U.K.
Inman M; School of Chemistry, University of Nottingham University Park, Nottingham, NG7 2RD, U.K.
Lewis W; School of Chemistry, University of Nottingham University Park, Nottingham, NG7 2RD, U.K.
Hayes CJ; School of Chemistry, University of Nottingham University Park, Nottingham, NG7 2RD, U.K.
Moody CJ; School of Chemistry, University of Nottingham University Park, Nottingham, NG7 2RD, U.K.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Oct 01; Vol. 27 (55), pp. 13703-13708. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Journal Article
MeSH Terms :
Alkynes*
Pyrazoles*
Cycloaddition Reaction ; Hydrazones
Czasopismo naukowe
Tytuł :
Reactivation of tuberculosis following ruxolitinib therapy for primary myelofibrosis: Case series and literature review.
Autorzy :
Khalid F; Division of Hematology and HSCT, Department of Oncology, King Abdul Aziz Medical City, Riyadh, Saudi Arabia.
Damlaj M; Division of Hematology and HSCT, Department of Oncology, King Abdul Aziz Medical City, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
AlZahrani M; Division of Hematology and HSCT, Department of Oncology, King Abdul Aziz Medical City, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Abuelgasim KA; Division of Hematology and HSCT, Department of Oncology, King Abdul Aziz Medical City, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Gmati GE; Division of Hematology and HSCT, Department of Oncology, King Abdul Aziz Medical City, Riyadh, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. Electronic address: .
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Źródło :
Hematology/oncology and stem cell therapy [Hematol Oncol Stem Cell Ther] 2021 Sep; Vol. 14 (3), pp. 252-256. Date of Electronic Publication: 2020 Mar 16.
Typ publikacji :
Case Reports; Journal Article; Review
MeSH Terms :
Hematopoietic Stem Cell Transplantation*
Pyrazoles*/administration & dosage
Pyrazoles*/adverse effects
Tuberculosis*/chemically induced
Tuberculosis*/immunology
Primary Myelofibrosis/*therapy
Th1 Cells/*immunology
Aged ; Allografts ; Cytokines/immunology ; Female ; Humans ; Male ; Middle Aged ; Primary Myelofibrosis/immunology
Czasopismo naukowe
Tytuł :
Substituted Pyrazoles and Their Heteroannulated Analogs-Recent Syntheses and Biological Activities.
Autorzy :
Ramadan M; Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assuit 71524, Egypt.
Aly AA; Chemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt.
El-Haleem LEA; Chemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt.
Alshammari MB; Chemistry Department, College of Sciences and Humanities, Prince Sattam Bin Abdulaziz University, P.O. Box 83, Al-Kharij 11942, Saudi Arabia.
Bräse S; Institute of Organic Chemistry, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.; Institute of Biological and Chemical Systems (IBCS-FMS), Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, Germany.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Aug 18; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Pyrazoles/*chemical synthesis
Pyrazoles/*pharmacology
Chemistry Techniques, Synthetic ; Humans ; Pyrazoles/chemistry
Czasopismo naukowe
Tytuł :
Severe Inflammation, Acute Kidney Injury, and Drug-Drug Interaction: Triple Penalty for Prolonged Elimination of Apixaban in Patients With Coronavirus Disease 2019: A Grand Round.
Autorzy :
Launay M; Laboratoire de Pharmacologie-Toxicologie-Gaz du Sang, CHU de Saint-Etienne, Saint Etienne, France.
Demartin AL; Laboratoire de Pharmacologie-Toxicologie-Gaz du Sang, CHU de Saint-Etienne, Saint Etienne, France.
Ragey SP; Service de Médecine Intensive et Réanimation G, CHU de Saint-Etienne, Saint Etienne, France.; INSERM U1059, Dysfonctions Vasculaires et de L'Hémostase, Université de Lyon, Saint-Etienne, France.
Mismetti P; Service de Médecine Vasculaire et Thérapeutique, CHU de Saint-Etienne, Saint Etienne, France; and.
Botelho-Nevers E; Infectious Diseases Department, CHU de Saint-Etienne, Saint Etienne, France.
Delavenne X; Laboratoire de Pharmacologie-Toxicologie-Gaz du Sang, CHU de Saint-Etienne, Saint Etienne, France.; INSERM U1059, Dysfonctions Vasculaires et de L'Hémostase, Université de Lyon, Saint-Etienne, France.
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Źródło :
Therapeutic drug monitoring [Ther Drug Monit] 2021 Aug 01; Vol. 43 (4), pp. 455-458.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Acute Kidney Injury/*metabolism
COVID-19/*metabolism
Drug Monitoring/*methods
Pyrazoles/*metabolism
Pyridones/*metabolism
Renal Elimination/*drug effects
Teaching Rounds/*methods
Acute Kidney Injury/chemically induced ; Acute Kidney Injury/prevention & control ; Aged, 80 and over ; Antiviral Agents/adverse effects ; Antiviral Agents/metabolism ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Drug Interactions/physiology ; Factor Xa Inhibitors/adverse effects ; Factor Xa Inhibitors/metabolism ; Factor Xa Inhibitors/therapeutic use ; Humans ; Inflammation/chemically induced ; Inflammation/metabolism ; Inflammation/prevention & control ; Male ; Pyrazoles/adverse effects ; Pyrazoles/therapeutic use ; Pyridones/adverse effects ; Pyridones/therapeutic use ; Renal Elimination/physiology ; Severity of Illness Index ; Time Factors
Czasopismo naukowe
Tytuł :
Asciminib: an investigational agent for the treatment of chronic myeloid leukemia.
Autorzy :
Breccia M; Department of Translational and Precision Medicine, Az. Policlinico Umberto I-Sapienza University, Rome, Italy.
Colafigli G; Department of Translational and Precision Medicine, Az. Policlinico Umberto I-Sapienza University, Rome, Italy.
Scalzulli E; Department of Translational and Precision Medicine, Az. Policlinico Umberto I-Sapienza University, Rome, Italy.
Martelli M; Department of Translational and Precision Medicine, Az. Policlinico Umberto I-Sapienza University, Rome, Italy.
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Źródło :
Expert opinion on investigational drugs [Expert Opin Investig Drugs] 2021 Aug; Vol. 30 (8), pp. 803-811. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*pharmacology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*drug therapy
Niacinamide/*analogs & derivatives
Pyrazoles/*pharmacology
Allosteric Regulation/drug effects ; Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Drug Resistance, Neoplasm ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Niacinamide/administration & dosage ; Niacinamide/adverse effects ; Niacinamide/pharmacology ; Protein Kinase Inhibitors/pharmacology ; Pyrazoles/administration & dosage ; Pyrazoles/adverse effects
Czasopismo naukowe
Tytuł :
Management of primary immune thrombocytopenia in a real-world setting in Japan: eltrombopag versus corticosteroids.
Autorzy :
Wong TF; Novartis Pharma KK, Tokyo, Japan.
Majewska R; Creativ-Ceutical, Kraków, Poland.
Tomiyama Y; Department of Blood Transfusion, Osaka University Hospital, Suita, Osaka, Japan. .
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Źródło :
International journal of hematology [Int J Hematol] 2021 Aug; Vol. 114 (2), pp. 152-163. Date of Electronic Publication: 2021 Apr 13.
Typ publikacji :
Journal Article
MeSH Terms :
Adrenal Cortex Hormones/*therapeutic use
Benzoates/*therapeutic use
Hydrazines/*therapeutic use
Purpura, Thrombocytopenic, Idiopathic/*drug therapy
Purpura, Thrombocytopenic, Idiopathic/*epidemiology
Pyrazoles/*therapeutic use
Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/adverse effects ; Benzoates/administration & dosage ; Benzoates/adverse effects ; Disease Management ; Disease Susceptibility ; Drug Therapy, Combination ; Hemorrhage/diagnosis ; Hemorrhage/epidemiology ; Hemorrhage/etiology ; Humans ; Hydrazines/administration & dosage ; Hydrazines/adverse effects ; Japan/epidemiology ; Kaplan-Meier Estimate ; Patient Acceptance of Health Care ; Platelet Count ; Practice Patterns, Physicians' ; Prevalence ; Prognosis ; Proportional Hazards Models ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Purpura, Thrombocytopenic, Idiopathic/etiology ; Pyrazoles/administration & dosage ; Pyrazoles/adverse effects ; Retrospective Studies ; Treatment Outcome
Czasopismo naukowe
Tytuł :
The dissipation behavior, household processing factor and risk assessment for cyenopyrafen residues in strawberry and mandarin fruits.
Autorzy :
Li Y; Ministry of Agriculture and Rural Affairs Key Laboratory for Pesticide Residue Detection, Institute of Agro-Products Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.
Xu J; Ministry of Agriculture and Rural Affairs Key Laboratory for Pesticide Residue Detection, Institute of Agro-Products Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.
Zhao X; Ministry of Agriculture and Rural Affairs Key Laboratory for Pesticide Residue Detection, Institute of Agro-Products Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.
He H; Ministry of Agriculture and Rural Affairs Key Laboratory for Pesticide Residue Detection, Institute of Agro-Products Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.
Zhang C; Ministry of Agriculture and Rural Affairs Key Laboratory for Pesticide Residue Detection, Institute of Agro-Products Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. Electronic address: .
Zhang Z; Ministry of Agriculture and Rural Affairs Key Laboratory for Pesticide Residue Detection, Institute of Agro-Products Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Oct 15; Vol. 359, pp. 129925. Date of Electronic Publication: 2021 Apr 22.
Typ publikacji :
Journal Article
MeSH Terms :
Acrylonitrile/*analogs & derivatives
Citrus sinensis/*chemistry
Fragaria/*chemistry
Fruit/*chemistry
Pesticide Residues/*chemistry
Pyrazoles/*chemistry
Acrylonitrile/analysis ; Acrylonitrile/chemistry ; Dietary Exposure ; Pesticide Residues/analysis ; Pyrazoles/analysis ; Risk Assessment
Czasopismo naukowe
Tytuł :
Immune modulating activity of the CHK1 inhibitor prexasertib and anti-PD-L1 antibody LY3300054 in patients with high-grade serous ovarian cancer and other solid tumors.
Autorzy :
Do KT; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue-DA2010, Boston, MA, 02215, USA. .
Manuszak C; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, USA.
Thrash E; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, USA.
Giobbie-Hurder A; Division of Biostatistics, Department of Data Science, Dana-Farber Cancer Institute, Boston, USA.
Hu J; Division of Biostatistics, Department of Data Science, Dana-Farber Cancer Institute, Boston, USA.
Kelland S; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue-DA2010, Boston, MA, 02215, USA.
Powers A; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue-DA2010, Boston, MA, 02215, USA.
de Jonge A; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue-DA2010, Boston, MA, 02215, USA.
Shapiro GI; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue-DA2010, Boston, MA, 02215, USA.
Severgnini M; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, USA.
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Oct; Vol. 70 (10), pp. 2991-3000. Date of Electronic Publication: 2021 Mar 20.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Cystadenocarcinoma, Serous/*drug therapy
Ovarian Neoplasms/*drug therapy
Pyrazines/*therapeutic use
Pyrazoles/*therapeutic use
Adult ; Aged ; Antineoplastic Agents/pharmacology ; Cystadenocarcinoma, Serous/pathology ; Female ; Humans ; Middle Aged ; Ovarian Neoplasms/pathology ; Pyrazines/pharmacology ; Pyrazoles/pharmacology
Czasopismo naukowe
Tytuł :
Altered K Ca 3.1 expression following burn injury and the therapeutic potential of TRAM-34 in post-burn hypertrophic scar formation.
Autorzy :
Seo CH; Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
Cui HS; Burn Institute, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
Kim JB; Department of Pediatrics, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea. Electronic address: .
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Źródło :
Translational research : the journal of laboratory and clinical medicine [Transl Res] 2021 Oct; Vol. 236, pp. 133-146. Date of Electronic Publication: 2021 Apr 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Burns/*drug therapy
Burns/*metabolism
Cicatrix, Hypertrophic/*drug therapy
Cicatrix, Hypertrophic/*etiology
Intermediate-Conductance Calcium-Activated Potassium Channels/*metabolism
Pyrazoles/*therapeutic use
Adolescent ; Adult ; Aged ; Animals ; Biomarkers/metabolism ; Burns/genetics ; Burns/pathology ; Calcium/metabolism ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Cell Proliferation/drug effects ; Cicatrix, Hypertrophic/genetics ; Cytosol/drug effects ; Cytosol/metabolism ; Female ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Humans ; Intermediate-Conductance Calcium-Activated Potassium Channels/genetics ; Male ; Mice ; Middle Aged ; Pyrazoles/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Lateral flow immunoassay for the simultaneous detection of fipronil and its metabolites in food samples.
Autorzy :
Yao J; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China; International Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China.
Wang Z; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China; International Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China.
Guo L; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China; International Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China.
Xu X; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China; International Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China.
Liu L; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China; International Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China. Electronic address: .
Kuang H; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China; International Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China. Electronic address: .
Xu C; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China; International Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China.
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Źródło :
Food chemistry [Food Chem] 2021 Sep 15; Vol. 356, pp. 129710. Date of Electronic Publication: 2021 Mar 27.
Typ publikacji :
Journal Article
MeSH Terms :
Food Analysis/*methods
Immunoassay/*methods
Pyrazoles/*analysis
Animals ; Chromatography, Liquid ; Eggs/analysis ; Gold/chemistry ; Haptens/chemistry ; Limit of Detection ; Metal Nanoparticles/chemistry ; Pyrazoles/metabolism ; Tandem Mass Spectrometry ; Time Factors
Czasopismo naukowe
Tytuł :
Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding.
Autorzy :
Wittwer K; Veterinary Medicine Division, Paul-Ehrlich-Institute, Langen, Germany.
Anderson DE; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Pfeffermann K; Veterinary Medicine Division, Paul-Ehrlich-Institute, Langen, Germany.
Cox RM; Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
Wolf JD; Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
Santibanez S; WHO European Regional Reference Laboratory for Measles and Rubella, Robert Koch-Institute, Berlin, Germany.
Mankertz A; WHO European Regional Reference Laboratory for Measles and Rubella, Robert Koch-Institute, Berlin, Germany.
Plesker R; Veterinary Medicine Division, Paul-Ehrlich-Institute, Langen, Germany.
Sticher ZM; Emory Institute for Drug Development, Emory University, Atlanta, GA, USA.
Kolkykhalov AA; Emory Institute for Drug Development, Emory University, Atlanta, GA, USA.
Natchus MG; Emory Institute for Drug Development, Emory University, Atlanta, GA, USA.
Pfaller CK; Veterinary Medicine Division, Paul-Ehrlich-Institute, Langen, Germany. .
Plemper RK; Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA. .
von Messling V; Veterinary Medicine Division, Paul-Ehrlich-Institute, Langen, Germany.; Life Sciences Unit, Federal Ministry of Education and Research, Berlin, Germany.
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Źródło :
Nature communications [Nat Commun] 2021 Sep 02; Vol. 12 (1), pp. 5233. Date of Electronic Publication: 2021 Sep 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Enzyme Inhibitors/*therapeutic use
Measles/*prevention & control
Morpholines/*therapeutic use
Piperidines/*therapeutic use
Pyrazoles/*therapeutic use
RNA-Dependent RNA Polymerase/*antagonists & inhibitors
Animals ; Drug Evaluation, Preclinical ; Enzyme Inhibitors/pharmacokinetics ; Immune Tolerance/drug effects ; Immunity, Humoral/drug effects ; Measles virus/drug effects ; Morpholines/pharmacokinetics ; Piperidines/pharmacokinetics ; Pyrazoles/pharmacokinetics ; Saimiri ; Virus Replication/drug effects ; Virus Shedding/drug effects
SCR Organism :
Saimiri boliviensis
Czasopismo naukowe
Tytuł :
Tuning a pyrazoline-based fluorogenic reagent, 3-naphthyl-1-(4-trifluoromethyl)-5-(4-carboxy phenyl)-2-pyrazoline for sensitive precolumn derivatization of aliphatic alcohols and trace analysis by RP-HPLC with fluorescence detection.
Autorzy :
Al-Sabahi A; Department of Chemistry, College of Science, Sultan Qaboos University, Sultanate of Oman.
Al-Busafi S; Department of Chemistry, College of Science, Sultan Qaboos University, Sultanate of Oman.
Varghese B; Department of Chemistry, College of Science, Sultan Qaboos University, Sultanate of Oman.
Al-Kindy S; Department of Chemistry, College of Science, Sultan Qaboos University, Sultanate of Oman.
Suliman F; Department of Chemistry, College of Science, Sultan Qaboos University, Sultanate of Oman.
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Źródło :
Biomedical chromatography : BMC [Biomed Chromatogr] 2021 Sep; Vol. 35 (9), pp. e5134. Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Journal Article
MeSH Terms :
Alcohols*/analysis
Alcohols*/chemistry
Chromatography, Reverse-Phase/*methods
Fluorescent Dyes/*chemistry
Pyrazoles/*chemistry
Spectrometry, Fluorescence/*methods
Chromatography, High Pressure Liquid/methods ; Fluorescent Dyes/analysis ; Limit of Detection ; Linear Models ; Pyrazoles/analysis ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Prevention of Lyme and other tickborne diseases using a rodent-targeted approach: A randomized controlled trial in Connecticut.
Autorzy :
Hinckley AF; Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Niesobecki SA; Connecticut Emerging Infections Program, Yale School of Public Health, New Haven, CT, USA.
Connally NP; Department of Biological & Environmental Sciences, Western Connecticut State University, Danbury, CT, USA.
Hook SA; Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Biggerstaff BJ; Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Horiuchi KA; Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Hojgaard A; Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Mead PS; Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Meek JI; Connecticut Emerging Infections Program, Yale School of Public Health, New Haven, CT, USA.
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Źródło :
Zoonoses and public health [Zoonoses Public Health] 2021 Sep; Vol. 68 (6), pp. 578-587. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Antiparasitic Agents/*pharmacology
Ixodes/*drug effects
Lyme Disease/*prevention & control
Pyrazoles/*pharmacology
Rodent Diseases/*parasitology
Tick Infestations/*veterinary
Animals ; Antiparasitic Agents/administration & dosage ; Connecticut ; Humans ; Ixodes/microbiology ; Pyrazoles/administration & dosage ; Rodent Diseases/drug therapy ; Rodentia ; Tick Infestations/drug therapy ; Tick Infestations/parasitology
Czasopismo naukowe
Tytuł :
JTE-013 Alleviates Inflammatory Injury and Endothelial Dysfunction Induced by Sepsis In Vivo and In Vitro.
Autorzy :
Xu Q; Emergency Department, The Fourth Sanatorium Area of Hangzhou Special Service Sanatorium Center of Air Force, Nanjing City, Jiangsu Province, China.
Chen J; Emergency Department, The Fourth Sanatorium Area of Hangzhou Special Service Sanatorium Center of Air Force, Nanjing City, Jiangsu Province, China.
Zhu Y; Convalescent Department, The Fourth Sanatorium Area of Hangzhou Special Service Sanatorium Center of Air Force, Nanjing City, Jiangsu Province, China.
Xia W; Emergency Department, The Fourth Sanatorium Area of Hangzhou Special Service Sanatorium Center of Air Force, Nanjing City, Jiangsu Province, China.
Liu Y; Emergency Department, The Fourth Sanatorium Area of Hangzhou Special Service Sanatorium Center of Air Force, Nanjing City, Jiangsu Province, China.
Xu J; Special Functions Section, The Fourth Sanatorium Area of Hangzhou Special Service Sanatorium Center of Air Force, Nanjing City, Jiangsu Province, China. Electronic address: .
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Źródło :
The Journal of surgical research [J Surg Res] 2021 Sep; Vol. 265, pp. 323-332. Date of Electronic Publication: 2021 May 07.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Lung Injury/*drug therapy
Endothelial Cells/*drug effects
Endothelium, Vascular/*drug effects
Pyrazoles/*therapeutic use
Pyridines/*therapeutic use
Sepsis/*complications
Acute Lung Injury/etiology ; Acute Lung Injury/metabolism ; Animals ; Cells, Cultured ; Drug Evaluation, Preclinical ; Humans ; Male ; Pyrazoles/pharmacology ; Pyridines/pharmacology ; Rats, Sprague-Dawley ; Sphingosine-1-Phosphate Receptors/antagonists & inhibitors ; Sphingosine-1-Phosphate Receptors/metabolism
Czasopismo naukowe
Tytuł :
Triple Therapy for Cystic Fibrosis Phe508del -Gating and -Residual Function Genotypes.
Autorzy :
Barry PJ; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Mall MA; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Álvarez A; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Colombo C; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
de Winter-de Groot KM; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Fajac I; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
McBennett KA; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
McKone EF; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Ramsey BW; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Sutharsan S; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Taylor-Cousar JL; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Tullis E; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Ahluwalia N; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Jun LS; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Moskowitz SM; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Prieto-Centurion V; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Tian S; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Waltz D; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Xuan F; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Zhang Y; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Rowe SM; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
Polineni D; From Manchester University NHS Foundation Trust, Manchester, United Kingdom (P.J.B.); Charité-Universitätsmedizin Berlin, the Berlin Institute of Health, and the German Center for Lung Research, Berlin (M.A.M.), and the Division of Cystic Fibrosis, Department of Pulmonary Medicine, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen (S.S.) - all in Germany; Vall d'Hebron Barcelona Hospital Campus, Barcelona (A.A.); Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and the University of Milan - both in Milan (C.C.); Wilhelmina Children's Hospital-University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (K.M.W.-G.); Assistance Publique-Hôpitaux de Paris (AP-HP) Centre-Université de Paris Hôpital Cochin AP-HP, Paris (I.F.); Rainbow Babies and Children's Hospital, Cleveland (K.A.M.); St. Vincent's University Hospital, Dublin (E.F.M.); Seattle Children's Hospital, Seattle (B.W.R.); National Jewish Health, Denver (J.L.T.-C.); St. Michael's Hospital, Toronto (E.T.); Vertex Pharmaceuticals, Boston (N.A., L.S.J., S.M.M., V.P.-C., S.T., D.W., F.X., Y.Z.); the University of Alabama at Birmingham, Birmingham (S.M.R.); and the University of Kansas Medical Center, Kansas City (D.P.).
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Corporate Authors :
VX18-445-104 Study Group
Źródło :
The New England journal of medicine [N Engl J Med] 2021 Aug 26; Vol. 385 (9), pp. 815-825.
Typ publikacji :
Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
MeSH Terms :
Aminophenols/*therapeutic use
Benzodioxoles/*therapeutic use
Chloride Channel Agonists/*therapeutic use
Cystic Fibrosis/*drug therapy
Indoles/*therapeutic use
Pyrazoles/*therapeutic use
Pyridines/*therapeutic use
Quinolines/*therapeutic use
Adolescent ; Adult ; Aminophenols/adverse effects ; Benzodioxoles/adverse effects ; Child ; Chloride Channel Agonists/adverse effects ; Chlorides/analysis ; Cystic Fibrosis/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Double-Blind Method ; Drug Combinations ; Female ; Genotype ; Humans ; Indoles/adverse effects ; Male ; Pyrazoles/adverse effects ; Pyridines/adverse effects ; Quinolines/adverse effects ; Sweat/chemistry
Czasopismo naukowe
Tytuł :
Estrogen suppresses HOXB2 expression via ERα in breast cancer cells.
Autorzy :
Kumar A; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
Dhillon A; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
Manjegowda MC; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
Singh N; Molecular and Cellular Biology Laboratory, ICMR-National Institute of Research in Reproductive Health, Indian Council of Medical Research (ICMR), Parel 400012, Mumbai, India.
Mary DJSJ; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
Kumar S; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
Modi D; Molecular and Cellular Biology Laboratory, ICMR-National Institute of Research in Reproductive Health, Indian Council of Medical Research (ICMR), Parel 400012, Mumbai, India.
Limaye AM; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India. Electronic address: .
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Źródło :
Gene [Gene] 2021 Aug 20; Vol. 794, pp. 145746. Date of Electronic Publication: 2021 May 29.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Breast Neoplasms/*genetics
Estrogen Receptor alpha/*genetics
Homeodomain Proteins/*genetics
Phenols/*administration & dosage
Pyrazoles/*administration & dosage
Transcription Factors/*genetics
Animals ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; MCF-7 Cells ; Mice ; Neoplasm Transplantation ; Phenols/pharmacology ; Promoter Regions, Genetic ; Pyrazoles/pharmacology
Czasopismo naukowe
Tytuł :
Efficacy and safety of tyrosine kinase inhibitors alone or in combination with radiation therapy for metastatic renal cell carcinoma: A protocol for evidence-based systematic review and Bayesian network meta-analysis.
Autorzy :
Wang S; Department of Pharmacy, The General Hospital of Western Theater Command, Sichuan, China.
Jin W
Jiang C
Zhang Y
Deng K
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Aug 20; Vol. 100 (33), pp. e27004.
Typ publikacji :
Journal Article
MeSH Terms :
Clinical Protocols*
Drug Therapy, Combination/*standards
Pyrazoles/*standards
Pyrimidines/*standards
Radiotherapy/*standards
Bayes Theorem ; Carcinoma, Renal Cell/therapy ; Humans ; Network Meta-Analysis ; Pyrazoles/therapeutic use ; Pyrimidines/therapeutic use ; Radiotherapy/methods ; Systematic Reviews as Topic
Czasopismo naukowe
Tytuł :
Structural Basis of Inhibition of DCLK1 by Ruxolitinib.
Autorzy :
Jang DM; Research Institute, National Cancer Center, Goyang 10408, Gyeonggi, Korea.
Lim HJ; Research Institute, National Cancer Center, Goyang 10408, Gyeonggi, Korea.
Hahn H; Research Institute, National Cancer Center, Goyang 10408, Gyeonggi, Korea.
Lee Y; Research Institute, National Cancer Center, Goyang 10408, Gyeonggi, Korea.
Kim HK; Research Institute, National Cancer Center, Goyang 10408, Gyeonggi, Korea.
Kim HS; Research Institute, National Cancer Center, Goyang 10408, Gyeonggi, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 06; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 06.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Intracellular Signaling Peptides and Proteins/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Protein-Serine-Threonine Kinases/*antagonists & inhibitors
Pyrazoles/*pharmacology
Antineoplastic Agents/chemistry ; Humans ; Intracellular Signaling Peptides and Proteins/chemistry ; Intracellular Signaling Peptides and Proteins/metabolism ; Molecular Docking Simulation ; Protein Conformation/drug effects ; Protein Kinase Inhibitors/chemistry ; Protein-Serine-Threonine Kinases/chemistry ; Protein-Serine-Threonine Kinases/metabolism ; Pyrazoles/chemistry
Czasopismo naukowe
Tytuł :
Study of thrombin generation with St Genesia to evaluate xaban pharmacodynamics: Analytical performances over 18 months.
Autorzy :
Foulon-Pinto G; Innovations Thérapeutiques en Hémostase, Université de Paris, INSERM, Paris, France.; Service d'Hématologie Biologique, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Jourdi G; Innovations Thérapeutiques en Hémostase, Université de Paris, INSERM, Paris, France.; Service d'Hématologie Biologique, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Perrin J; Université de Lorraine, INSERM, DCAC, Nancy, France.; Service d'Hématologie Biologique, Pôle Laboratoires, CHRU Nancy, Nancy, France.
Abdoul J; Innovations Thérapeutiques en Hémostase, Université de Paris, INSERM, Paris, France.; Service d'Hématologie Biologique, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Paris G; Innovations Thérapeutiques en Hémostase, Université de Paris, INSERM, Paris, France.; Service d'Hématologie Biologique, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Gouin-Thibault I; INSERM, CIC 1414 (Centre d'Investigation Clinique de Rennes), Université de Rennes, CHU de Rennes, Rennes, France.; Service d'Hématologie Biologique, CHU de Rennes, Rennes, France.
Curis E; UR 7537 BioSTM, Faculté de Pharmacie, Université de Paris, Paris, France.; Service de Biostatistique et Information Médicale, AP-HP, Hôpital Saint-Louis, Paris, France.
Lecompte T; Département de Médecine, Faculté de Médecine - GpG, Hôpitaux Universitaires de Genève, Unité d'hémostase, Université de Genève, Geneva, Switzerland.
Siguret V; Innovations Thérapeutiques en Hémostase, Université de Paris, INSERM, Paris, France.; Service d'Hématologie Biologique, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
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Źródło :
International journal of laboratory hematology [Int J Lab Hematol] 2021 Aug; Vol. 43 (4), pp. 821-830. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
Blood Coagulation/*drug effects
Factor Xa Inhibitors/*pharmacology
Pyrazoles/*pharmacology
Pyridones/*pharmacology
Rivaroxaban/*pharmacology
Blood Coagulation Tests ; Factor Xa Inhibitors/blood ; Humans ; Pyrazoles/blood ; Pyridones/blood ; Reproducibility of Results ; Rivaroxaban/blood ; Thrombin/metabolism
Czasopismo naukowe

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