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Wyszukujesz frazę ""Pyridines"" wg kryterium: Temat


Tytuł :
Synthesis, electronic structures, and reactivity of mononuclear and dinuclear low-valent molybdenum complexes in iminopyridine and bis(imino)pyridine ligand environments.
Autorzy :
Dissanayake AI; Department of Chemistry, Wayne State University, 5101 Cass Ave, Detroit, MI 48202, USA.
Hollingsworth TS; Department of Chemistry, Wayne State University, 5101 Cass Ave, Detroit, MI 48202, USA.
Kurup SS; Department of Chemistry, Wayne State University, 5101 Cass Ave, Detroit, MI 48202, USA.
Wannipurage D; Department of Chemistry, Wayne State University, 5101 Cass Ave, Detroit, MI 48202, USA.
Hamilton PN; BASF Corporation, 1609 Biddle Ave, Wyandotte, MI 48192, USA. Electronic address: .
Lord RL; Department of Chemistry, Grand Valley State University, Allendale, MI 49401, USA. Electronic address: .
Groysman S; Department of Chemistry, Wayne State University, 5101 Cass Ave, Detroit, MI 48202, USA. Electronic address: .
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Źródło :
Journal of inorganic biochemistry [J Inorg Biochem] 2022 May; Vol. 230, pp. 111744. Date of Electronic Publication: 2022 Feb 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molybdenum*/chemistry
Pyridines*/chemistry
Crystallography, X-Ray ; Electronics ; Ligands
Czasopismo naukowe
Tytuł :
Novel therapeutic strategy for melanoma based on albendazole and the CDK4/6 inhibitor palbociclib.
Autorzy :
Zhu L; Molecular Biology Research Center, Center for Medical Genetics, Hunan Province Key Laboratory of Basic and Applied Hematology, Medical Genetics and School of Life Sciences, Central South University, Changsha, 410078, China.; Department of Dermatology, Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Clinical Research Center for Cancer Immunotherapy, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Yang Q; Molecular Biology Research Center, Center for Medical Genetics, Hunan Province Key Laboratory of Basic and Applied Hematology, Medical Genetics and School of Life Sciences, Central South University, Changsha, 410078, China.; School of Medical Laboratory, Shao Yang University, Shaoyang, 422000, Hunan Province, China.
Hu R; Molecular Biology Research Center, Center for Medical Genetics, Hunan Province Key Laboratory of Basic and Applied Hematology, Medical Genetics and School of Life Sciences, Central South University, Changsha, 410078, China.
Li Y; Molecular Biology Research Center, Center for Medical Genetics, Hunan Province Key Laboratory of Basic and Applied Hematology, Medical Genetics and School of Life Sciences, Central South University, Changsha, 410078, China.
Peng Y; Molecular Biology Research Center, Center for Medical Genetics, Hunan Province Key Laboratory of Basic and Applied Hematology, Medical Genetics and School of Life Sciences, Central South University, Changsha, 410078, China.
Liu H; Department of Dermatology, Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Clinical Research Center for Cancer Immunotherapy, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Ye M; Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha, 410082, Hunan, China.
Zhang B; Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, 410013, China.
Zhang P; Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, 410013, China.
Liu-Smith F; Molecular Biology Research Center, Center for Medical Genetics, Hunan Province Key Laboratory of Basic and Applied Hematology, Medical Genetics and School of Life Sciences, Central South University, Changsha, 410078, China.
Li H; Molecular Biology Research Center, Center for Medical Genetics, Hunan Province Key Laboratory of Basic and Applied Hematology, Medical Genetics and School of Life Sciences, Central South University, Changsha, 410078, China. .; Department of Dermatology, Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Clinical Research Center for Cancer Immunotherapy, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. .; Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha, 410082, Hunan, China. .
Liu J; Molecular Biology Research Center, Center for Medical Genetics, Hunan Province Key Laboratory of Basic and Applied Hematology, Medical Genetics and School of Life Sciences, Central South University, Changsha, 410078, China. .
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Źródło :
Scientific reports [Sci Rep] 2022 Apr 05; Vol. 12 (1), pp. 5706. Date of Electronic Publication: 2022 Apr 05.
Typ publikacji :
Journal Article
MeSH Terms :
Albendazole*/pharmacology
Albendazole*/therapeutic use
Melanoma*/genetics
Piperazines*/pharmacology
Piperazines*/therapeutic use
Pyridines*/pharmacology
Pyridines*/therapeutic use
Animals ; Cell Line, Tumor ; Cyclin-Dependent Kinase 4/antagonists & inhibitors ; Cyclin-Dependent Kinase 6/antagonists & inhibitors ; Humans ; Mice
Czasopismo naukowe
Tytuł :
Synthesis and biological evaluation of 4-(pyridine-4-oxy)-3-(tetrahydro-2H-pyran-4-yl)-pyrazole derivatives as novel, potent of ALK5 receptor inhibitors.
Autorzy :
Wang Z; School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, China; R &D Center, Nanjing Sanhome Pharmaceutical Co. Ltd., Nanjing, Jiangsu 211135, China.
Zhang Y; R &D Center, Nanjing Sanhome Pharmaceutical Co. Ltd., Nanjing, Jiangsu 211135, China.
Wang H; R &D Center, Nanjing Sanhome Pharmaceutical Co. Ltd., Nanjing, Jiangsu 211135, China.
Wang X; R &D Center, Nanjing Sanhome Pharmaceutical Co. Ltd., Nanjing, Jiangsu 211135, China.
Yu Z; R &D Center, Nanjing Sanhome Pharmaceutical Co. Ltd., Nanjing, Jiangsu 211135, China.
Zhao L; R &D Center, Nanjing Sanhome Pharmaceutical Co. Ltd., Nanjing, Jiangsu 211135, China. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Apr 01; Vol. 61, pp. 128552. Date of Electronic Publication: 2022 Jan 18.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Pyrazoles/*pharmacology
Pyridines/*pharmacology
Receptor, Transforming Growth Factor-beta Type I/*antagonists & inhibitors
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Mice ; Molecular Structure ; NIH 3T3 Cells ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Pyrazoles/chemical synthesis ; Pyrazoles/chemistry ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Receptor, Transforming Growth Factor-beta Type I/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
1 H -Pyrazolo[3,4- b ]pyridines: Synthesis and Biomedical Applications.
Autorzy :
Donaire-Arias A; Grup de Química Farmacèutica, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain.
Montagut AM; Grup de Química Farmacèutica, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain.
Puig de la Bellacasa R; Grup de Química Farmacèutica, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain.
Estrada-Tejedor R; Grup de Química Farmacèutica, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain.
Teixidó J; Grup de Química Farmacèutica, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain.
Borrell JI; Grup de Química Farmacèutica, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2022 Mar 30; Vol. 27 (7). Date of Electronic Publication: 2022 Mar 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Pyridines*/therapeutic use
Czasopismo naukowe
Tytuł :
Pharmacodynamic Modeling of CDK4/6 Inhibition-Related Biomarkers and the Characterization of the Relationship Between Biomarker Response and Progression-Free Survival in Patients With Advanced Breast Cancer.
Autorzy :
Yu Y; Pfizer, Clinical Pharmacology, San Diego, California, USA.
Sun W; Vertex, Clinical Pharmacology, Boston, Massachusetts, USA.
Liu Y; Pfizer, Translational Oncology, San Diego, California, USA.
Wang D; Pfizer, Clinical Pharmacology, San Diego, California, USA.
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Źródło :
Journal of clinical pharmacology [J Clin Pharmacol] 2022 Mar; Vol. 62 (3), pp. 376-384. Date of Electronic Publication: 2021 Nov 16.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Breast Neoplasms/*drug therapy
Ki-67 Antigen/*blood
Piperazines/*pharmacology
Pyridines/*pharmacology
Retinoblastoma Protein/*blood
Thymidine Kinase/*blood
Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor ; Breast Neoplasms/pathology ; China ; Cyclin-Dependent Kinase 4/antagonists & inhibitors ; Cyclin-Dependent Kinase 6/antagonists & inhibitors ; Female ; Humans ; Ki-67 Antigen/drug effects ; Metabolic Clearance Rate ; Models, Biological ; Neoplasm Staging ; Piperazines/pharmacokinetics ; Piperazines/therapeutic use ; Progression-Free Survival ; Pyridines/pharmacokinetics ; Pyridines/therapeutic use ; Retinoblastoma Protein/drug effects ; Thymidine Kinase/drug effects
Czasopismo naukowe
Tytuł :
Design, synthesis and anti-breast cancer evaluation of biaryl pyridine analogues as potent RSK inhibitors.
Autorzy :
Cui YM; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Li W; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China; Kunming College of Life Sciences, The University of the Chinese Academy of Sciences, Kunming 650201, China.
Shen TZ; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Tao YX; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Liu BQ; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Li XL; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Zhang RH; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Jiang DW; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China; Kunming College of Life Sciences, The University of the Chinese Academy of Sciences, Kunming 650201, China. Electronic address: .
Xiao WL; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Mar 01; Vol. 59, pp. 128565. Date of Electronic Publication: 2022 Jan 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Pyridines/*pharmacology
Ribosomal Protein S6 Kinases, 90-kDa/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Ribosomal Protein S6 Kinases, 90-kDa/metabolism ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Access to Thienopyridine and Thienoquinoline Derivatives via Site-Selective C-H Bond Functionalization and Annulation.
Autorzy :
He R; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529090, China.
Liu Y; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529090, China.
Feng Y; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529090, China.
Chen L; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529090, China.
Huang Y; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529090, China.
Xie F; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529090, China.
Li Y; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529090, China.
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Źródło :
Organic letters [Org Lett] 2022 May 06; Vol. 24 (17), pp. 3167-3172. Date of Electronic Publication: 2022 Apr 25.
Typ publikacji :
Journal Article
MeSH Terms :
Pyridines*
Thienopyridines*/chemistry
Cyclization ; Sulfur
Czasopismo naukowe
Tytuł :
Ethynyl-SF 4 -Pyridines: Reagents for SF 4 -Alkynylation to Carbonyl Compounds.
Autorzy :
Iwaki K; Department of Nanopharmaceutical Sciences & Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan.
Maruno K; Department of Nanopharmaceutical Sciences & Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan.
Nagata O; Pharmaceutical Division, Ube Industries, Ltd., Seavans North Bldg, 1-2-1 Shibaura, Minato-ku, Tokyo 105-8449, Japan.
Shibata N; Department of Nanopharmaceutical Sciences & Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan.
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Źródło :
The Journal of organic chemistry [J Org Chem] 2022 May 06; Vol. 87 (9), pp. 6302-6311. Date of Electronic Publication: 2022 Apr 18.
Typ publikacji :
Journal Article
MeSH Terms :
Alcohols*
Pyridines*
Indicators and Reagents
Czasopismo naukowe
Tytuł :
Recent synthetic methodologies for imidazo[1,5- a ]pyridines and related heterocycles.
Autorzy :
Ramana Reddy M; James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA, 45267-0514. .
Darapaneni CM; Paraza Pharma Inc., Montreal, Canada, H4S 2E1.
Patil RD; School of Chemical Sciences, Moolji Jaitha College, Jalgaon, Maharashratra, India, 425001.
Kumari H; James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA, 45267-0514. .
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Źródło :
Organic & biomolecular chemistry [Org Biomol Chem] 2022 May 04; Vol. 20 (17), pp. 3440-3468. Date of Electronic Publication: 2022 May 04.
Typ publikacji :
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms :
Imidazoles*/chemistry
Pyridines*/chemistry
Cyclization ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Dual blockade of MET and VEGFR2 signaling pathways as a potential therapeutic maneuver for peritoneal carcinomatosis in scirrhous gastric cancer.
Autorzy :
Kasai S; Division of Medical Oncology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Ishikawa, 920-0293, Japan.
Kuwayama N; Division of Medical Oncology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Ishikawa, 920-0293, Japan.
Motoo Y; Division of Medical Oncology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Ishikawa, 920-0293, Japan.
Kawashima A; Kanazawa Medical Center, Kanazawa, 920-8650, Japan.
Matsumoto K; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.
Yano S; Department of Medical Oncology, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-0934, Japan.
Matsushima K; Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science, Chiba, 278-0022, Japan.
Yasumoto K; Division of Medical Oncology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Ishikawa, 920-0293, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Apr 16; Vol. 600, pp. 80-86. Date of Electronic Publication: 2022 Feb 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anilides*/pharmacology
Peritoneal Neoplasms*/drug therapy
Peritoneal Neoplasms*/metabolism
Peritoneal Neoplasms*/pathology
Proto-Oncogene Proteins c-met*/antagonists & inhibitors
Pyridines*/pharmacology
Stomach Neoplasms*/drug therapy
Stomach Neoplasms*/metabolism
Stomach Neoplasms*/pathology
Vascular Endothelial Growth Factor Receptor-2*/antagonists & inhibitors
Animals ; Ascites/drug therapy ; Cell Line, Tumor ; Humans ; Mice ; Mice, Nude ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
hERG Optimization of Benzofuro-Pyridine and Pyrazino-Indole Derivatives as MCHR1 Antagonists.
Autorzy :
Huszár J; Department of Chemistry, Gedeon Richter Plc., Gyömrői út 19-21, 1103, Budapest, Hungary.
Bozó É; Department of Chemistry, Gedeon Richter Plc., Gyömrői út 19-21, 1103, Budapest, Hungary.
Beke G; Department of Chemistry, Gedeon Richter Plc., Gyömrői út 19-21, 1103, Budapest, Hungary.
Katalin Szalai K; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Gyömrői út 19-21, 1103, Budapest, Hungary.
Kardos P; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Gyömrői út 19-21, 1103, Budapest, Hungary.
Boros A; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Gyömrői út 19-21, 1103, Budapest, Hungary.
Greiner I; Research Directorate, Gedeon Richter Plc., Gyömrői út 19-21, 1103, Budapest, Hungary.
Éles J; Department of Chemistry, Gedeon Richter Plc., Gyömrői út 19-21, 1103, Budapest, Hungary.
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Źródło :
ChemMedChem [ChemMedChem] 2022 Apr 05; Vol. 17 (7), pp. e202100707. Date of Electronic Publication: 2022 Feb 03.
Typ publikacji :
Journal Article
MeSH Terms :
Pyridines*/pharmacology
Receptors, Somatostatin*
Humans ; Obesity/drug therapy ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Atogepant: an emerging treatment for migraine.
Autorzy :
Rustichelli C; Department of Life Sciences, University of Modena and Reggio Emilia, via Campi, Modena, Italy.
Avallone R; Department of Life Sciences, University of Modena and Reggio Emilia, via Campi, Modena, Italy.
Ferrari A; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, via del Pozzo, Modena, Italy.
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Źródło :
Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2022 Apr; Vol. 23 (6), pp. 653-662. Date of Electronic Publication: 2022 Mar 28.
Typ publikacji :
Journal Article
MeSH Terms :
Migraine Disorders*/drug therapy
Piperidines*/adverse effects
Pyridines*/adverse effects
Pyrroles*/adverse effects
Spiro Compounds*/adverse effects
Adult ; Antibodies, Monoclonal ; Calcitonin Gene-Related Peptide ; Calcitonin Gene-Related Peptide Receptor Antagonists/therapeutic use ; Humans
Czasopismo naukowe
Tytuł :
Vanadium complexes with polypyridyl ligands: Speciation, structure and potential medicinal activity.
Autorzy :
Hernández L; Laboratorio de Equilibrios en Solución, Universidad Simón Bolívar (USB), Apartado 89000, Caracas 1080 A, Venezuela. Electronic address: .
Araujo ML; Centro de Equilibrios en Solución, Escuela de Química, Facultad de Ciencias, Universidad Central de Venezuela, Venezuela.
Madden W; Laboratorio de Equilibrios en Solución, Universidad Simón Bolívar (USB), Apartado 89000, Caracas 1080 A, Venezuela.
Del Carpio E; Laboratorio de Equilibrios en Solución, Universidad Simón Bolívar (USB), Apartado 89000, Caracas 1080 A, Venezuela; Unidad de Química Medicinal, Facultad de Farmacia, Escuela 'Dr. Jesús María Bianco', Universidad Central de Venezuela, Venezuela.
Lubes V; Laboratorio de Equilibrios en Solución, Universidad Simón Bolívar (USB), Apartado 89000, Caracas 1080 A, Venezuela.
Lubes G; Laboratorio de Equilibrios en Solución, Universidad Simón Bolívar (USB), Apartado 89000, Caracas 1080 A, Venezuela.
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Źródło :
Journal of inorganic biochemistry [J Inorg Biochem] 2022 Apr; Vol. 229, pp. 111712. Date of Electronic Publication: 2022 Jan 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*pharmacology
Coordination Complexes/*pharmacology
Pyridines/*pharmacology
Animals ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Coordination Complexes/chemistry ; Drug Screening Assays, Antitumor ; Humans ; Ligands ; Molecular Structure ; Phenanthrolines/chemistry ; Phenanthrolines/pharmacology ; Pyridines/chemistry ; Vanadium/chemistry
Czasopismo naukowe
Tytuł :
DYRK1A suppression attenuates HIF‑1α accumulation and enhances the anti‑liver cancer effects of regorafenib and sorafenib under hypoxic conditions.
Autorzy :
Zhang C; Department of Pharmacology, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, P.R. China.
Wu LW; Department of Pharmacology, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, P.R. China.
Li ZD; Department of Pharmacology, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, P.R. China.
Zhang MM; Department of Pharmacology, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, P.R. China.
Wu J; School of Pharmaceutical and Materials Engineering and Institute for Advanced Studies, Taizhou University, Taizhou, Jiangsu 318000, P.R. China.
Du FH; Department of Pharmacology, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, P.R. China.
Zeng LH; Department of Pharmacology, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, P.R. China.
Li YL; Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, P.R. China.
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Źródło :
International journal of oncology [Int J Oncol] 2022 Apr; Vol. 60 (4). Date of Electronic Publication: 2022 Mar 04.
Typ publikacji :
Journal Article
MeSH Terms :
Hypoxia/*metabolism
Hypoxia-Inducible Factor 1, alpha Subunit/*antagonists & inhibitors
Liver Neoplasms/*drug therapy
Phenylurea Compounds/*pharmacology
Protein Serine-Threonine Kinases/*antagonists & inhibitors
Protein-Tyrosine Kinases/*antagonists & inhibitors
Pyridines/*pharmacology
Sorafenib/*pharmacokinetics
Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Liver Neoplasms/physiopathology ; Phenylurea Compounds/metabolism ; Protective Factors ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/metabolism ; Pyridines/metabolism ; Sorafenib/metabolism
Czasopismo naukowe
Tytuł :
Design and Self-Assembly of Macrocycles with Metals at the Corners Based on Dissymmetric Terpyridine Ligands.
Autorzy :
Xu Y; State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, Jilin, 130012, P. R. China.
Su H; State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, Jilin, 130012, P. R. China.
Bai Q; Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou, Guangdong, 510006, P. R. China.
Fang F; Instrumental Analysis Center, Shenzhen University, Shenzhen, Guangdong, 518055, P. R. China.
Ma J; State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, Jilin, 130012, P. R. China.
Zhang Z; Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou, Guangdong, 510006, P. R. China.
Hao XQ; College of Chemistry and Green Catalysis Center, Zhengzhou University, Zhengzhou, Henan, 450001, P. R. China.
Shi J; State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, Jilin, 130012, P. R. China.
Wang P; Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou, Guangdong, 510006, P. R. China.
Wang M; State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, Jilin, 130012, P. R. China.
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Źródło :
Chemistry, an Asian journal [Chem Asian J] 2022 Apr 01; Vol. 17 (7), pp. e202200071. Date of Electronic Publication: 2022 Mar 04.
Typ publikacji :
Journal Article
MeSH Terms :
Metals*/chemistry
Pyridines*/chemistry
Ions/chemistry ; Ligands ; Polymers/chemistry
Czasopismo naukowe
Tytuł :
BF 3 -etherate promoted facile access to vinyloxyimidazopyridines: a metal-free sustainable approach.
Autorzy :
Tiwari SK; Laboratory of Green Synthesis, Department of Chemistry, University of Allahabad, Prayagraj, 211002, India.
Nazeef M; Laboratory of Green Synthesis, Department of Chemistry, University of Allahabad, Prayagraj, 211002, India.
Verma A; Laboratory of Green Synthesis, Department of Chemistry, University of Allahabad, Prayagraj, 211002, India.
Kumar A; Department of Chemistry, University of Delhi, New Delhi, India.
Yadav V; Laboratory of Green Synthesis, Department of Chemistry, University of Allahabad, Prayagraj, 211002, India.
Yadav N; Laboratory of Green Synthesis, Department of Chemistry, University of Allahabad, Prayagraj, 211002, India.
Ansari S; Laboratory of Green Synthesis, Department of Chemistry, University of Allahabad, Prayagraj, 211002, India.
Siddiqui IR; Laboratory of Green Synthesis, Department of Chemistry, University of Allahabad, Prayagraj, 211002, India. .
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Źródło :
Molecular diversity [Mol Divers] 2022 Apr; Vol. 26 (2), pp. 1259-1266. Date of Electronic Publication: 2021 May 16.
Typ publikacji :
Journal Article
MeSH Terms :
Pyridines*
Catalysis
Czasopismo naukowe
Tytuł :
Green synthesis and biological activities assessment of some new chromeno[2,3-b]pyridine derivatives.
Autorzy :
Azarifar D; Department of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
Ghaemi M; Department of Chemistry, Bu-Ali Sina University, Hamedan, Iran. .
Jaymand M; Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. .
Karamian R; Department of Biology, Faculty of Science, Bu-Ali Sina University, Hamedan, Iran.
Asadbegy M; Department of Biology, Faculty of Science, Bu-Ali Sina University, Hamedan, Iran.
Ghasemlou F; Department of Biology, Faculty of Science, Bu-Ali Sina University, Hamedan, Iran.
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Źródło :
Molecular diversity [Mol Divers] 2022 Apr; Vol. 26 (2), pp. 891-902. Date of Electronic Publication: 2021 Apr 16.
Typ publikacji :
Journal Article
MeSH Terms :
Magnetite Nanoparticles*/chemistry
Pyridines*/pharmacology
Antioxidants/pharmacology ; Catalysis ; Solvents
Czasopismo naukowe
Tytuł :
Pyridine interaction with γ-CuI: synergy between molecular dynamics and molecular orbital approaches to molecule/surface interactions.
Autorzy :
Duston TB; Department of Chemistry, William & Mary, Williamsburg, VA 23187, USA. .
Pike RD; Department of Chemistry, William & Mary, Williamsburg, VA 23187, USA. .
Welch DA; Chemistry Department, Farmingdale State College, Farmingdale, NY, 11784, USA. .
Nicholas AD; Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, WA, 99354, USA. .
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Źródło :
Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2022 Mar 30; Vol. 24 (13), pp. 7950-7960. Date of Electronic Publication: 2022 Mar 30.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Dynamics Simulation*
Pyridines*/chemistry
Copper ; Hydrogen Bonding
Czasopismo naukowe
Tytuł :
Symmetric bis-benzimidazoles as DNA minor groove-binding agents with anti-tumour and antibacterial activity, and the evolution of the drug ridinilazole for the treatment of Clostridium difficile infections.
Autorzy :
Baron A; School of Chemistry, Queen's University Belfast, Belfast BT9 5AG, UK.
Sann CL; School of Chemistry, Queen's University Belfast, Belfast BT9 5AG, UK.
Mann J; School of Chemistry, Queen's University Belfast, Belfast BT9 5AG, UK. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 Mar 15; Vol. 58, pp. 116656. Date of Electronic Publication: 2022 Feb 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Antineoplastic Agents/*pharmacology
Benzimidazoles/*pharmacology
Clostridium Infections/*drug therapy
DNA/*chemistry
Pyridines/*pharmacology
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Benzimidazoles/chemical synthesis ; Benzimidazoles/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Crystallography, X-Ray ; Drug Screening Assays, Antitumor ; Humans ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Pyridines/chemistry
Czasopismo naukowe
Tytuł :
Synthesis and Structural Characterization of Pyridine-2,6-dicarboxamide and Furan-2,5-dicarboxamide Derivatives.
Autorzy :
Puckowska A; Department of Organic Chemistry, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Bialystok, Mickiewicza 2A, 15-222 Bialystok, Poland.
Gawel M; Department of Structural Biology of Prokaryotic Organisms, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-074 Poznan, Poland.
Komorowska M; Department of Structural Biology of Prokaryotic Organisms, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-074 Poznan, Poland.
Drozdzal P; Department of Structural Biology of Prokaryotic Organisms, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-074 Poznan, Poland.
Arning A; Department of Structural Biology of Prokaryotic Organisms, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-074 Poznan, Poland.; Faculty of Chemistry, A. Mickiewicz University, Uniwersytetu Poznanskiego 8, 60-780 Poznan, Poland.
Pawelski D; Department of Organic Chemistry, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Bialystok, Mickiewicza 2A, 15-222 Bialystok, Poland.
Brzezinski K; Department of Structural Biology of Prokaryotic Organisms, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-074 Poznan, Poland.
Plonska-Brzezinska ME; Department of Organic Chemistry, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Bialystok, Mickiewicza 2A, 15-222 Bialystok, Poland.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2022 Mar 10; Vol. 27 (6). Date of Electronic Publication: 2022 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Furans*
Pyridines*/chemistry
Amides/chemistry ; Magnetic Resonance Spectroscopy
Czasopismo naukowe

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