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Wyszukujesz frazę ""Pyridinium Compounds"" wg kryterium: Temat


Tytuł :
Developing Push-Pull Hydroxylphenylpolyenylpyridinium Chromophores as Ratiometric Two-Photon Fluorescent Probes for Cellular and Intravital Imaging of Mitochondrial NQO1.
Autorzy :
Yang YP; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
Qi FJ; Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, Lanzhou 730000, P. R. China.
Qian YP; School of Chemical Science and Technology, Gannan Normal University, Ganzhou 341000, P. R. China.
Bao XZ; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
Zhang HC; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
Ma B; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
Dai F; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
Zhang SX; Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, Lanzhou 730000, P. R. China.
Zhou B; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
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Źródło :
Analytical chemistry [Anal Chem] 2021 Feb 02; Vol. 93 (4), pp. 2385-2393. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fluorescent Dyes/*chemistry
Mitochondria/*metabolism
NAD(P)H Dehydrogenase (Quinone)/*metabolism
Pyridinium Compounds/*chemistry
Animals ; Brain/blood supply ; Cell Line ; Cell Survival/drug effects ; Diagnostic Imaging ; Humans ; Intravital Microscopy/methods ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; NAD(P)H Dehydrogenase (Quinone)/chemistry ; Pyridinium Compounds/chemical synthesis ; Pyridinium Compounds/toxicity ; Rats ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Design, synthesis and biological evaluation of edaravone derivatives bearing the N -benzyl pyridinium moiety as multifunctional anti-Alzheimer's agents.
Autorzy :
Zondagh LS; Pharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Bellville, South Africa.
Malan SF; Pharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Bellville, South Africa.
Joubert J; Pharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Bellville, South Africa.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1596-1605.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Docking Simulation*
Alzheimer Disease/*drug therapy
Cholinesterase Inhibitors/*pharmacology
Edaravone/*pharmacology
Neuroprotective Agents/*pharmacology
Pyridinium Compounds/*pharmacology
Acetylcholinesterase/metabolism ; Alzheimer Disease/metabolism ; Animals ; Butyrylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Drug Design ; Edaravone/chemical synthesis ; Edaravone/chemistry ; Electrophorus ; Horses ; Molecular Structure ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; Pyridinium Compounds/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Pyridinium derivatives of 3-aminobenzenesulfonamide are nanomolar-potent inhibitors of tumor-expressed carbonic anhydrase isozymes CA IX and CA XII.
Autorzy :
Akocak S; Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia PA-19140, United States.
Güzel-Akdemir Ö; NEUROFARBA Department, Università degli Studi di Firenze, Polo Scientifico, Via della Lastruccia 3, 50019 Sesto Fiorentino (Florence), Italy; Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 34116 Beyazıt, Istanbul, Turkey.
Kishore Kumar Sanku R; Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia PA-19140, United States.
Russom SS; Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia PA-19140, United States.
Iorga BI; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles (ICSN), 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
Supuran CT; NEUROFARBA Department, Università degli Studi di Firenze, Polo Scientifico, Via della Lastruccia 3, 50019 Sesto Fiorentino (Florence), Italy. Electronic address: .
Ilies MA; Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia PA-19140, United States. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Oct; Vol. 103, pp. 104204. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Neoplasm/*metabolism
Antineoplastic Agents/*pharmacology
Carbonic Anhydrase IX/*metabolism
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Neoplasms/*enzymology
Pyridinium Compounds/*pharmacology
Sulfonamides/*pharmacology
Antigens, Neoplasm/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Base Sequence ; Carbonic Anhydrase IX/chemistry ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/metabolism ; Carbonic Anhydrases/chemistry ; Catalytic Domain ; Cell Line, Tumor ; Drug Design ; Drug Screening Assays, Antitumor ; Humans ; Molecular Docking Simulation ; Protein Binding ; Pyridinium Compounds/chemical synthesis ; Pyridinium Compounds/metabolism ; Sulfonamides/chemical synthesis ; Sulfonamides/metabolism
Czasopismo naukowe
Tytuł :
Design, synthesis, biological evaluation, and docking study of novel dual-acting thiazole-pyridiniums inhibiting acetylcholinesterase and β-amyloid aggregation for Alzheimer's disease.
Autorzy :
Ghotbi G; Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Medicinal Chemistry, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Mahdavi M; Endocrinology & Metabolism Research Institute (EMRI), Tehran University of Medical Sciences, Tehran, Iran.
Najafi Z; Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Moghadam FH; Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.
Hamzeh-Mivehroud M; Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Medicinal Chemistry, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Davaran S; Department of Medicinal Chemistry, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Dastmalchi S; Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Medicinal Chemistry, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Faculty of Pharmacy, Near East University, POBOX:99138, Nicosia, North Cyprus, Mersin 10, Turkey. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Oct; Vol. 103, pp. 104186. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid beta-Peptides/*metabolism
Cholinesterase Inhibitors/*pharmacology
Neuroprotective Agents/*pharmacology
Peptide Fragments/*metabolism
Protein Multimerization/*drug effects
Pyridinium Compounds/*pharmacology
Thiazoles/*pharmacology
Acetylcholinesterase/metabolism ; Animals ; Butyrylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/metabolism ; Molecular Docking Simulation ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/metabolism ; PC12 Cells ; Pyridinium Compounds/chemical synthesis ; Pyridinium Compounds/metabolism ; Rats ; Thiazoles/chemical synthesis ; Thiazoles/metabolism
Czasopismo naukowe
Tytuł :
Codelivery of HIF-1α siRNA and Dinaciclib by Carboxylated Graphene Oxide-Trimethyl Chitosan-Hyaluronate Nanoparticles Significantly Suppresses Cancer Cell Progression.
Autorzy :
Izadi S; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Moslehi A; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Kheiry H; Division of Genetics, Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran.
Karoon Kiani F; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Ahmadi A; Department of Chemical and Materials Engineering, The University of Alabama in Huntsville, Huntsville, Alabama, 35899, USA.
Masjedi A; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Ghani S; Student Research Committee, Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Rafiee B; Department of Biology, Faculty of Basic Science, Payame Noor University, Tehran, Iran.
Karpisheh V; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Hajizadeh F; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Atyabi F; Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Assali A; Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Mirzazadeh Tekie FS; Department of radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Namdar A; Department of Oncology, Cross Cancer Institute, The University of Alberta, Edmonton, Alberta, Canada.
Ghalamfarsa G; Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
Sojoodi M; Division of Surgical Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, USA. .
Jadidi-Niaragh F; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. .; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. .
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Źródło :
Pharmaceutical research [Pharm Res] 2020 Sep 17; Vol. 37 (10), pp. 196. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article
MeSH Terms :
Bridged Bicyclo Compounds, Heterocyclic/*administration & dosage
Hypoxia-Inducible Factor 1, alpha Subunit/*genetics
Neoplasms, Experimental/*therapy
Pyridinium Compounds/*administration & dosage
RNA, Small Interfering/*administration & dosage
Animals ; Bridged Bicyclo Compounds, Heterocyclic/chemistry ; Bridged Bicyclo Compounds, Heterocyclic/pharmacokinetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Chitosan/chemistry ; Graphite/chemistry ; Hyaluronic Acid/chemistry ; Mice ; Nanoparticles/chemistry ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Pyridinium Compounds/chemistry ; Pyridinium Compounds/pharmacokinetics ; RNA, Small Interfering/chemistry ; RNA, Small Interfering/genetics ; RNA, Small Interfering/pharmacokinetics
Czasopismo naukowe
Tytuł :
The effect of polar head group of dodecyl surfactants on the growth of wheat and cucumber.
Autorzy :
Tot A; University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg D. Obradovića 3, 21000, Novi Sad, Serbia.
Maksimović I; University of Novi Sad, Faculty of Agriculture, Trg D. Obradovića 8, 21000, Novi Sad, Serbia.
Putnik-Delić M; University of Novi Sad, Faculty of Agriculture, Trg D. Obradovića 8, 21000, Novi Sad, Serbia.
Daničić M; University of Novi Sad, Faculty of Agriculture, Trg D. Obradovića 8, 21000, Novi Sad, Serbia.
Gadžurić S; University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg D. Obradovića 3, 21000, Novi Sad, Serbia.
Bešter-Rogač M; University of Ljubljana, Faculty of Chemistry and Chemical Technology, Večna Pot 113, 1000, Ljubljana, Slovenia.
Vraneš M; University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg D. Obradovića 3, 21000, Novi Sad, Serbia. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2020 Sep; Vol. 254, pp. 126918. Date of Electronic Publication: 2020 Apr 29.
Typ publikacji :
Journal Article
MeSH Terms :
Cucumis sativus/*drug effects
Imidazoles/*toxicity
Pyridinium Compounds/*toxicity
Surface-Active Agents/*toxicity
Triticum/*drug effects
Cations ; Cell Membrane/chemistry ; Cell Membrane/drug effects ; Cucumis sativus/growth & development ; Germination/drug effects ; Imidazoles/chemistry ; Lipid Bilayers/chemistry ; Molecular Dynamics Simulation ; Pyridinium Compounds/chemistry ; Pyridinium Compounds/pharmacology ; Seedlings/drug effects ; Seedlings/growth & development ; Seeds/drug effects ; Seeds/growth & development ; Structure-Activity Relationship ; Surface-Active Agents/chemistry ; Triticum/growth & development
Czasopismo naukowe
Tytuł :
Pyridinium-Substituted Tetraphenylethylenes Functionalized with Alkyl Chains as Autophagy Modulators for Cancer Therapy.
Autorzy :
Huang Y; Beijing National Laboratory for Molecular Sciences, CAS Key Laboratories of Organic Solids and Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemistry, University of Chinese Academy of Sciences, Beijing, 100049, China.
You X; Beijing National Laboratory for Molecular Sciences, CAS Key Laboratories of Organic Solids and Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemistry, University of Chinese Academy of Sciences, Beijing, 100049, China.
Wang L; Beijing National Laboratory for Molecular Sciences, CAS Key Laboratories of Organic Solids and Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemistry, University of Chinese Academy of Sciences, Beijing, 100049, China.
Zhang G; Beijing National Laboratory for Molecular Sciences, CAS Key Laboratories of Organic Solids and Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemistry, University of Chinese Academy of Sciences, Beijing, 100049, China.
Gui S; Beijing National Laboratory for Molecular Sciences, CAS Key Laboratories of Organic Solids and Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemistry, University of Chinese Academy of Sciences, Beijing, 100049, China.
Jin Y; Beijing National Laboratory for Molecular Sciences, CAS Key Laboratories of Organic Solids and Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemistry, University of Chinese Academy of Sciences, Beijing, 100049, China.
Zhao R; Beijing National Laboratory for Molecular Sciences, CAS Key Laboratories of Organic Solids and Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemistry, University of Chinese Academy of Sciences, Beijing, 100049, China.
Zhang D; Beijing National Laboratory for Molecular Sciences, CAS Key Laboratories of Organic Solids and Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; School of Chemistry, University of Chinese Academy of Sciences, Beijing, 100049, China.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Jun 15; Vol. 59 (25), pp. 10042-10051. Date of Electronic Publication: 2020 Apr 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Autophagy/*drug effects
Pyridinium Compounds/*chemistry
Pyridinium Compounds/*pharmacology
Stilbenes/*chemistry
Stilbenes/*pharmacology
Alkylation ; Antineoplastic Agents/therapeutic use ; Cell Fusion ; Cell Line, Tumor ; Hep G2 Cells ; Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Pyridinium Compounds/therapeutic use ; Stilbenes/therapeutic use
Czasopismo naukowe
Tytuł :
Custom G4 Microarrays Reveal Selective G-Quadruplex Recognition of Small Molecule BMVC: A Large-Scale Assessment of Ligand Binding Selectivity.
Autorzy :
Wu G; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 W Stadium Ave, West Lafayette, IN 47907, USA.
Tillo D; Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Ray S; Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Chang TC; Institute of Atomic and Molecular Sciences, Academia Sinica, P.O. Box 23-166, Taipei 106, Taiwan.
Schneekloth JS Jr; Chemical Biology Laboratory, National Cancer Institute-Frederick, Frederick, MD 21702, USA.
Vinson C; Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Yang D; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 W Stadium Ave, West Lafayette, IN 47907, USA.; Purdue Center for Cancer Research, West Lafayette, IN 47906, USA.; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Jul 30; Vol. 25 (15). Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article
MeSH Terms :
G-Quadruplexes*
Carbazoles/*metabolism
Fluorescent Dyes/*metabolism
Proto-Oncogene Proteins c-myc/*genetics
Pyridinium Compounds/*metabolism
Carbazoles/chemistry ; Fluorescence ; Fluorescent Dyes/chemistry ; Humans ; Ligands ; Microarray Analysis ; Promoter Regions, Genetic ; Proto-Oncogene Proteins c-myc/metabolism ; Pyridinium Compounds/chemistry
Czasopismo naukowe
Tytuł :
Oxidation of Isodrimeninol with PCC Yields Drimane Derivatives with Activity against Candida Yeast by Inhibition of Lanosterol 14-Alpha Demethylase.
Autorzy :
Marin V; Laboratory of Natural Products & Drug Discovery, Department of Basic Science, Universidad de La Frontera, Av. Francisco Salazar 01145, 4780000 Temuco, Chile.
Iturra A; Laboratory of Natural Products & Drug Discovery, Department of Basic Science, Universidad de La Frontera, Av. Francisco Salazar 01145, 4780000 Temuco, Chile.
Opazo A; Universidad de Concepción, Departamento de Microbiología, Laboratorio de Investigación en Agentes Antibacterianos (LIAA), Barrio Universitario S/N, 160-C 1807 Concepción, Chile.
Schmidt B; Universität Potsdam, Institut für Chemie, Karl-Liebknecht-Str. 24-25, D-14476 Potsdam, Germany.
Heydenreich M; Universität Potsdam, Institut für Chemie, Karl-Liebknecht-Str. 24-25, D-14476 Potsdam, Germany.
Ortiz L; Universidad Austral de Chile, Instituto de Ciencias Química, Facultad de Ciencias, Universidad Austral de Chile, Casilla 567, 5091000 Valdivia, Chile.
Jiménez VA; Universidad Andres Bello, Sede Concepción, Departamento de Ciencias Químicas, Facultad de Ciencias Exactas, Autopista Concepción-Talcahuano 7100, 4030000 Talcahuano, Chile.
Paz C; Laboratory of Natural Products & Drug Discovery, Department of Basic Science, Universidad de La Frontera, Av. Francisco Salazar 01145, 4780000 Temuco, Chile.
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Źródło :
Biomolecules [Biomolecules] 2020 Jul 24; Vol. 10 (8). Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
14-alpha Demethylase Inhibitors/*chemistry
Candida/*growth & development
Polycyclic Sesquiterpenes/*chemistry
Pyridinium Compounds/*chemistry
Sesquiterpenes/*chemistry
Sterol 14-Demethylase/*chemistry
14-alpha Demethylase Inhibitors/chemical synthesis ; 14-alpha Demethylase Inhibitors/pharmacology ; Antifungal Agents/chemical synthesis ; Antifungal Agents/chemistry ; Antifungal Agents/pharmacology ; Candida/classification ; Candida/drug effects ; Catalytic Domain ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Docking Simulation ; Molecular Structure ; Oxidation-Reduction ; Polycyclic Sesquiterpenes/chemical synthesis ; Polycyclic Sesquiterpenes/pharmacology ; Protein Domains ; Pyridinium Compounds/metabolism ; Sesquiterpenes/chemical synthesis ; Sesquiterpenes/pharmacology ; Sterol 14-Demethylase/metabolism
Czasopismo naukowe
Tytuł :
Photoresponsivity and antibiotic sensing properties of an entangled tris(pyridinium)-based metal-organic framework.
Autorzy :
Li P; Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China. .
Guo MY
Gao LL
Yin XM
Yang SL
Bu R
Gao EQ
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Źródło :
Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2020 Jun 14; Vol. 49 (22), pp. 7488-7495. Date of Electronic Publication: 2020 May 22.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*analysis
Fluorescent Dyes/*chemistry
Metal-Organic Frameworks/*chemistry
Nitrofurans/*analysis
Pyridinium Compounds/*chemistry
Fluorescent Dyes/chemical synthesis ; Metal-Organic Frameworks/chemical synthesis ; Photochemical Processes ; Pyridinium Compounds/chemical synthesis ; Spectrometry, Fluorescence
Czasopismo naukowe
Tytuł :
Novel composite unit with one pyridinium and three N-halamine structures for enhanced synergism and superior biocidability on magnetic nanoparticles.
Autorzy :
Chen Y; Department of Applied Chemistry, College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, PR China. Electronic address: .
Feng C; Department of Applied Chemistry, College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, PR China.
Chen Q; Department of Applied Chemistry, College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, PR China.
Yu H; Department of Applied Chemistry, College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, PR China.
Wang Y; Department of Applied Chemistry, College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, PR China.
Han Q; Department of Biological Engineering, College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, PR China. Electronic address: .
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Źródło :
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2020 Jun; Vol. 190, pp. 110890. Date of Electronic Publication: 2020 Feb 21.
Typ publikacji :
Journal Article
MeSH Terms :
Amines/*pharmacology
Anti-Bacterial Agents/*pharmacology
Escherichia coli/*drug effects
Magnetite Nanoparticles/*chemistry
Pyridinium Compounds/*pharmacology
Staphylococcus aureus/*drug effects
Amines/chemistry ; Anti-Bacterial Agents/chemistry ; Microbial Sensitivity Tests ; Molecular Structure ; Particle Size ; Pyridinium Compounds/chemistry ; Surface Properties
Czasopismo naukowe
Tytuł :
Novel Insights into the Thioesterolytic Activity of N -Substituted Pyridinium-4-oximes.
Autorzy :
Foretić B; Department of Chemistry and Biochemistry, School of Medicine, University of Zagreb, Šalata 3, HR-10000 Zagreb, Croatia.
Damjanović V; Department of Chemistry and Biochemistry, School of Medicine, University of Zagreb, Šalata 3, HR-10000 Zagreb, Croatia.
Vianello R; Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička 54, HR-10000 Zagreb, Croatia.
Picek I; Department of Chemistry and Biochemistry, School of Medicine, University of Zagreb, Šalata 3, HR-10000 Zagreb, Croatia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 May 21; Vol. 25 (10). Date of Electronic Publication: 2020 May 21.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylthiocholine/*chemistry
Cholinesterase Inhibitors/*chemistry
Oximes/*chemistry
Pyridinium Compounds/*chemistry
Acetylthiocholine/metabolism ; Catalysis/drug effects ; Cholinesterase Inhibitors/therapeutic use ; Cholinesterase Reactivators/chemistry ; Computational Chemistry ; Humans ; Kinetics ; Oximes/pharmacology ; Pyridinium Compounds/pharmacology
Czasopismo naukowe
Tytuł :
Synergistic Anti Leukemia Effect of a Novel Hsp90 and a Pan Cyclin Dependent Kinase Inhibitors.
Autorzy :
Abdalla AN; College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Abdallah ME; Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Aslam A; Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Bader A; College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Vassallo A; Dipartimento di Scienze, Università Degli Studi della Basilicata, 85100 Potenza, Italy.
Tommasi N; Dipartimento di Farmacia, Università Degli Studi di Salerno, 84084 Fisciano (SA), Italy.
Malki WH; College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Gouda AM; Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
Mukhtar MH; Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
El-Readi MZ; Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia.; Faculty of Pharmacy, Al-Azhar University, Assiut, 71524, Egypt.
Alkahtani HM; College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Abdel-Aziz AA; College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
El-Azab AS; College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 May 08; Vol. 25 (9). Date of Electronic Publication: 2020 May 08.
Typ publikacji :
Journal Article
MeSH Terms :
Leukemia, Myeloid, Acute*/drug therapy
Leukemia, Myeloid, Acute*/metabolism
Leukemia, Myeloid, Acute*/pathology
Antineoplastic Agents/*pharmacology
Cyclic N-Oxides/*pharmacology
Cyclin-Dependent Kinases/*antagonists & inhibitors
HSP90 Heat-Shock Proteins/*antagonists & inhibitors
Indolizines/*pharmacology
Neoplasm Proteins/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Pyridinium Compounds/*pharmacology
Apoptosis/drug effects ; Cyclic N-Oxides/agonists ; Cyclin-Dependent Kinases/metabolism ; Drug Synergism ; HL-60 Cells ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Indolizines/agonists ; Neoplasm Proteins/metabolism ; Pyridinium Compounds/agonists
Czasopismo naukowe
Tytuł :
4,4'-(((1E,5E)-pentane-1,5-diylidene)bis(azanylylidene))bis(1-dodecylpyridin-1-ium) bromide as a novel corrosion inhibitor in an acidic solution (part I).
Autorzy :
Hegazy MA; Egyptian Petroleum Research Institute (EPRI), Nasr City, Cairo 11727, Egypt. Electronic address: .
Samy RM; Egyptian Petroleum Research Institute (EPRI), Nasr City, Cairo 11727, Egypt.
Labena A; Egyptian Petroleum Research Institute (EPRI), Nasr City, Cairo 11727, Egypt. Electronic address: .
Wadaan MAM; Bioproducts Research Chair, Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Hozzein WN; Bioproducts Research Chair, Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; Botany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62511, Egypt.
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Źródło :
Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2020 May; Vol. 110, pp. 110673. Date of Electronic Publication: 2020 Jan 16.
Typ publikacji :
Journal Article
MeSH Terms :
Acids/*chemistry
Pyridinium Compounds/*chemistry
Adsorption ; Computer Simulation ; Corrosion ; Dielectric Spectroscopy ; Proton Magnetic Resonance Spectroscopy ; Pyridinium Compounds/chemical synthesis ; Solutions ; Spectroscopy, Fourier Transform Infrared ; Surface Tension ; Surface-Active Agents/chemical synthesis ; Surface-Active Agents/chemistry ; Temperature
Czasopismo naukowe
Tytuł :
Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness.
Autorzy :
Zdarova Karasova J; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence in Brno Hradec Kralove, Czech Republic; Biomedical Research Center, University Hospital, Hradec Kralove, Czech Republic. Electronic address: .
Hepnarova V; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence in Brno Hradec Kralove, Czech Republic; Biomedical Research Center, University Hospital, Hradec Kralove, Czech Republic.
Andrys R; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Lisa M; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Jost P; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence in Brno Hradec Kralove, Czech Republic; Biomedical Research Center, University Hospital, Hradec Kralove, Czech Republic.
Muckova L; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence in Brno Hradec Kralove, Czech Republic; Biomedical Research Center, University Hospital, Hradec Kralove, Czech Republic.
Pejchal J; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence in Brno Hradec Kralove, Czech Republic.
Herman D; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence in Brno Hradec Kralove, Czech Republic; Biomedical Research Center, University Hospital, Hradec Kralove, Czech Republic.
Jun D; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence in Brno Hradec Kralove, Czech Republic; Biomedical Research Center, University Hospital, Hradec Kralove, Czech Republic.
Kassa J; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence in Brno Hradec Kralove, Czech Republic.
Kuca K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Mar 01; Vol. 320, pp. 64-72. Date of Electronic Publication: 2019 Nov 30.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcholinesterase/*blood
Acetylcholinesterase/*metabolism
Brain/*drug effects
Bridged-Ring Compounds/*pharmacokinetics
Cholinesterase Reactivators/*pharmacokinetics
Erythrocytes/*drug effects
Imidazoles/*pharmacokinetics
Oximes/*pharmacokinetics
Pyridinium Compounds/*pharmacokinetics
A549 Cells ; Animals ; Brain/enzymology ; Bridged-Ring Compounds/administration & dosage ; Bridged-Ring Compounds/toxicity ; Cell Survival/drug effects ; Cholinesterase Reactivators/administration & dosage ; Cholinesterase Reactivators/toxicity ; Dose-Response Relationship, Drug ; Erythrocytes/enzymology ; Female ; GPI-Linked Proteins/blood ; GPI-Linked Proteins/metabolism ; Hep G2 Cells ; Humans ; Imidazoles/administration & dosage ; Imidazoles/toxicity ; Injections, Intramuscular ; Male ; Maximum Tolerated Dose ; Mice, Inbred ICR ; Oximes/administration & dosage ; Oximes/toxicity ; Pyridinium Compounds/administration & dosage ; Pyridinium Compounds/toxicity ; Risk Assessment ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Molecular determinants of binding of non-oxime bispyridinium nerve agent antidote compounds to the adult muscle nAChR.
Autorzy :
Epstein M; Department of Biochemistry, Structural Bioinformatics and Computational Biochemistry, University of Oxford, Oxford, UK.
Bali K; Department of Biochemistry, Structural Bioinformatics and Computational Biochemistry, University of Oxford, Oxford, UK; Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge, UK.
Piggot TJ; Chemical, Biological and Radiological Sciences Division, Defence Science and Technology Laboratory (DSTL), Porton Down, Salisbury, Wiltshire, UK.
Green AC; Chemical, Biological and Radiological Sciences Division, Defence Science and Technology Laboratory (DSTL), Porton Down, Salisbury, Wiltshire, UK.
Timperley CM; Chemical, Biological and Radiological Sciences Division, Defence Science and Technology Laboratory (DSTL), Porton Down, Salisbury, Wiltshire, UK.
Bird M; Chemical, Biological and Radiological Sciences Division, Defence Science and Technology Laboratory (DSTL), Porton Down, Salisbury, Wiltshire, UK.
Tattersall JEH; Chemical, Biological and Radiological Sciences Division, Defence Science and Technology Laboratory (DSTL), Porton Down, Salisbury, Wiltshire, UK.
Bermudez I; Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK.
Biggin PC; Department of Biochemistry, Structural Bioinformatics and Computational Biochemistry, University of Oxford, Oxford, UK. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Apr 01; Vol. 340, pp. 114-122. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article
MeSH Terms :
Antidotes/*chemistry
Antidotes/*pharmacology
Nerve Agents/*toxicity
Nicotinic Antagonists/*toxicity
Receptors, Nicotinic/*metabolism
Animals ; Models, Molecular ; Molecular Docking Simulation ; Oocytes/metabolism ; Protein Conformation ; Pyridinium Compounds ; Structure-Activity Relationship ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Normalization of LC-MS mycotoxin determination using the N-alkylpyridinium-3-sulfonates (NAPS) retention index system.
Autorzy :
Renaud JB; London Research and Development Centre, Agriculture and Agri-Food Canada, London, Ontario, N5V 4T3, Canada.
Hoogstra S; London Research and Development Centre, Agriculture and Agri-Food Canada, London, Ontario, N5V 4T3, Canada.
Quilliam MA; Biotoxin Metrology, National Research Council Canada, Halifax, Nova Scotia, B3H 3Z1, Canada.
Sumarah MW; London Research and Development Centre, Agriculture and Agri-Food Canada, London, Ontario, N5V 4T3, Canada. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Feb 22; Vol. 1639, pp. 461901. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatography, Liquid/*methods
Mycotoxins/*analysis
Polymers/*chemistry
Pyridinium Compounds/*chemistry
Penicillium/metabolism ; Secondary Metabolism ; Tandem Mass Spectrometry
SCR Organism :
Penicillium roqueforti
Czasopismo naukowe
Tytuł :
Glyceraldehyde-Derived Pyridinium Evokes Renal Tubular Cell Damage via RAGE Interaction.
Autorzy :
Sotokawauchi A; Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume 830-0011, Japan.
Nakamura N; Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume 830-0011, Japan.
Matsui T; Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume 830-0011, Japan.
Higashimoto Y; Department of Chemistry, Kurume University School of Medicine, Kurume 830-0011, Japan.
Yamagishi SI; Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Apr 09; Vol. 21 (7). Date of Electronic Publication: 2020 Apr 09.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelial Cells/*drug effects
Epithelial Cells/*metabolism
Glycation End Products, Advanced/*metabolism
Glyceraldehyde/*pharmacology
Kidney Tubules/*drug effects
Kidney Tubules/*metabolism
Pyridinium Compounds/*pharmacology
Biomarkers ; Cells, Cultured ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/pathology ; Glycation End Products, Advanced/pharmacology ; Glyceraldehyde/analogs & derivatives ; Humans ; Kidney Tubules/pathology ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/metabolism ; Kidney Tubules, Proximal/pathology ; Oxidative Stress/drug effects ; Pyridinium Compounds/chemistry ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
In vitro cytotoxicity assessment of monocationic and dicationic pyridinium-based ionic liquids on HeLa, MCF-7, BGM and EA.hy926 cell lines.
Autorzy :
Pérez SA; Chemical Engineering Department, Faculty of Chemistry, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, 30071, Murcia, Spain.
Montalbán MG; Chemical Engineering Department, University of Alicante, Apartado 99, 03080, Alicante, Spain. Electronic address: .
Carissimi G; Chemical Engineering Department, Faculty of Chemistry, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, 30071, Murcia, Spain.
Licence P; School of Chemistry, The University of Nottingham, University Park, Nottingham, UK.
Víllora G; Chemical Engineering Department, Faculty of Chemistry, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, 30071, Murcia, Spain.
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Źródło :
Journal of hazardous materials [J Hazard Mater] 2020 Mar 05; Vol. 385, pp. 121513. Date of Electronic Publication: 2019 Oct 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ionic Liquids/*toxicity
Pyridinium Compounds/*toxicity
Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Chlorocebus aethiops ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Ionic Liquids/chemistry ; Molecular Structure ; Pyridinium Compounds/chemistry ; S Phase Cell Cycle Checkpoints/drug effects ; Toxicity Tests
Czasopismo naukowe
Tytuł :
Rational Combination Therapy for Melanoma with Dinaciclib by Targeting BAK-Dependent Cell Death.
Autorzy :
Xu X; Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Eshima S; Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Kato S; Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, Toyama, Japan.; Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Massachusetts.
Fisher DE; Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Massachusetts.
Sakurai H; Department of Cancer Cell Biology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Hayakawa Y; Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Yokoyama S; Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, Toyama, Japan. .; Department of Cancer Cell Biology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
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Źródło :
Molecular cancer therapeutics [Mol Cancer Ther] 2020 Feb; Vol. 19 (2), pp. 627-636. Date of Electronic Publication: 2019 Nov 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Death/*drug effects
Cyclic N-Oxides/*therapeutic use
Cyclin-Dependent Kinases/*therapeutic use
Drug Therapy, Combination/*methods
Indolizines/*therapeutic use
Melanoma/*drug therapy
Pyridinium Compounds/*therapeutic use
Cell Line, Tumor ; Cyclic N-Oxides/pharmacology ; Cyclin-Dependent Kinases/pharmacology ; Humans ; Indolizines/pharmacology ; Pyridinium Compounds/pharmacology
Czasopismo naukowe

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