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Tytuł :
Inborn errors in the vitamin B6 salvage enzymes associated with neonatal epileptic encephalopathy and other pathologies.
Autorzy :
Ghatge MS; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, 23298, USA; Institute for Structural Biology, Drug Discovery, and Development, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Al Mughram M; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, 23298, USA; Institute for Structural Biology, Drug Discovery, and Development, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Omar AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Alsulaymanyah, Jeddah, 21589, Saudi Arabia; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, 11884, Egypt.
Safo MK; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, 23298, USA; Institute for Structural Biology, Drug Discovery, and Development, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, 23298, USA. Electronic address: .
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Źródło :
Biochimie [Biochimie] 2021 Apr; Vol. 183, pp. 18-29. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Brain Diseases, Metabolic*/genetics
Brain Diseases, Metabolic*/metabolism
Hypoxia-Ischemia, Brain*/genetics
Hypoxia-Ischemia, Brain*/metabolism
Metabolism, Inborn Errors*/genetics
Metabolism, Inborn Errors*/metabolism
Phosphotransferases (Alcohol Group Acceptor)*/genetics
Phosphotransferases (Alcohol Group Acceptor)*/metabolism
Pyridoxal Phosphate*/genetics
Pyridoxal Phosphate*/metabolism
Seizures*/genetics
Seizures*/metabolism
Pyridoxaminephosphate Oxidase/*deficiency
Animals ; Humans ; Infant, Newborn ; Pyridoxaminephosphate Oxidase/genetics ; Pyridoxaminephosphate Oxidase/metabolism
SCR Disease Name :
Pyridoxamine 5-Prime-Phosphate Oxidase Deficiency
Czasopismo naukowe
Tytuł :
Structural attributes and substrate specificity of pyridoxal kinase from Leishmania donovani.
Autorzy :
Are S; Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad 500 046, Telangana, India.
Gatreddi S; Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad 500 046, Telangana, India.
Jakkula P; Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad 500 046, Telangana, India.
Qureshi IA; Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad 500 046, Telangana, India. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Jun 01; Vol. 152, pp. 812-827. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji :
Journal Article
MeSH Terms :
Leishmania donovani/*metabolism
Pyridoxal Kinase/*chemistry
Pyridoxal Kinase/*metabolism
Substrate Specificity/*physiology
Amino Acid Sequence ; Catalytic Domain/physiology ; Humans ; Phosphotransferases (Alcohol Group Acceptor)/chemistry ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Protein Conformation ; Pyridoxal Phosphate/chemistry ; Pyridoxal Phosphate/metabolism ; Pyridoxamine/chemistry ; Pyridoxamine/metabolism ; Pyridoxine/analogs & derivatives ; Pyridoxine/chemistry ; Pyridoxine/metabolism
Czasopismo naukowe
Tytuł :
Pyridoxal Reductase, PdxI, Is Critical for Salvage of Pyridoxal in Escherichia coli.
Autorzy :
Ito T; Department of Microbiology, University of Georgia, Athens, Georgia, USA .; Department of Applied Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan.
Downs DM; Department of Microbiology, University of Georgia, Athens, Georgia, USA.
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Źródło :
Journal of bacteriology [J Bacteriol] 2020 May 27; Vol. 202 (12). Date of Electronic Publication: 2020 May 27 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Escherichia coli/*enzymology
Oxidoreductases/*metabolism
Pyridoxal/*biosynthesis
Biosynthetic Pathways ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Oxidoreductases/genetics ; Pyridoxal Phosphate/analogs & derivatives ; Pyridoxal Phosphate/metabolism
Czasopismo naukowe
Tytuł :
Underground metabolism facilitates the evolution of novel pathways for vitamin B6 biosynthesis.
Autorzy :
Richts B; Department of General Microbiology, Institute for Microbiology and Genetics, University of Goettingen, Grisebachstrasse 8, 37077, Göttingen, Germany.
Commichau FM; FG Synthetic Microbiology, Institute for Biotechnology, BTU Cottbus-Senftenberg, Universitätsplatz 1, 01968, Senftenberg, Germany. .
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Źródło :
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2021 Mar; Vol. 105 (6), pp. 2297-2305. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Escherichia coli*/genetics
Escherichia coli*/metabolism
Pyridoxal Phosphate*/metabolism
Animals ; Bacillus subtilis/genetics ; Bacillus subtilis/metabolism ; Biosynthetic Pathways/genetics ; Humans ; Pyridoxine ; Vitamin B 6
Czasopismo naukowe
Tytuł :
An Unexpected Role for the Periplasmic Phosphatase PhoN in the Salvage of B 6 Vitamers in Salmonella enterica.
Autorzy :
Vu HN; Department of Microbiology, The University of Georgia, Athens, Georgia, USA.
Downs DM; Department of Microbiology, The University of Georgia, Athens, Georgia, USA .
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Źródło :
Applied and environmental microbiology [Appl Environ Microbiol] 2021 Jan 15; Vol. 87 (3). Date of Electronic Publication: 2021 Jan 15 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Bacterial Proteins/*metabolism
Periplasm/*enzymology
Phosphoric Monoester Hydrolases/*metabolism
Pyridoxal Phosphate/*analogs & derivatives
Salmonella enterica/*enzymology
Escherichia coli/genetics ; Pyridoxal Phosphate/metabolism ; Salmonella enterica/genetics
Czasopismo naukowe
Tytuł :
Genome-wide analysis of high-risk primary brain cancer pedigrees identifies PDXDC1 as a candidate brain cancer predisposition gene.
Autorzy :
Cannon-Albright LA; Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah, USA.; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah, USA.; Huntsman Cancer Institute, Salt Lake City, Utah, USA.
Farnham JM; Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Stevens J; Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Teerlink CC; Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Palmer CA; Huntsman Cancer Institute, Salt Lake City, Utah, USA.; Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.; ARUP Laboratories, Salt Lake City, Utah, USA.
Rowe K; Intermountain Healthcare, Salt Lake City, Utah, USA.
Cessna MH; Intermountain Healthcare, Salt Lake City, Utah, USA.; Intermountain Biorepository and Department of Pathology, Intermountain Healthcare, Salt Lake City, Utah, USA.
Blumenthal DT; Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, Israel.
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Źródło :
Neuro-oncology [Neuro Oncol] 2021 Feb 25; Vol. 23 (2), pp. 277-283.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Brain Neoplasms*/genetics
Pyridoxal*
Genetic Predisposition to Disease ; Humans ; Pedigree ; Utah
Czasopismo naukowe
Tytuł :
Human serine racemase is inhibited by glyceraldehyde 3-phosphate, but not by glyceraldehyde 3-phosphate dehydrogenase.
Autorzy :
Michielon A; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Marchesani F; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Faggiano S; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy; Istituto di Biofisica, CNR, Via G. Moruzzi 1, 56124 Pisa, Italy.
Giaccari R; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Campanini B; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Bettati S; Dipartimento di Medicina e Chirurgia, Via Volturno 39, 43125 Parma, Italy.
Mozzarelli A; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy; Istituto di Biofisica, CNR, Via G. Moruzzi 1, 56124 Pisa, Italy.
Bruno S; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Proteins and proteomics [Biochim Biophys Acta Proteins Proteom] 2021 Jan; Vol. 1869 (1), pp. 140544. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Journal Article
MeSH Terms :
Adenosine Triphosphate/*chemistry
Enzyme Inhibitors/*chemistry
Glyceraldehyde 3-Phosphate/*chemistry
Glyceraldehyde-3-Phosphate Dehydrogenases/*chemistry
Pyridoxal Phosphate/*chemistry
Racemases and Epimerases/*chemistry
2,3-Diphosphoglycerate/chemistry ; 2,3-Diphosphoglycerate/metabolism ; Adenosine Triphosphate/metabolism ; Aldehydes/chemistry ; Aldehydes/metabolism ; Catalytic Domain ; Cloning, Molecular ; Enzyme Inhibitors/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Glyceraldehyde/chemistry ; Glyceraldehyde/metabolism ; Glyceraldehyde 3-Phosphate/metabolism ; Glyceraldehyde-3-Phosphate Dehydrogenases/genetics ; Glyceraldehyde-3-Phosphate Dehydrogenases/metabolism ; Humans ; Kinetics ; Models, Molecular ; Protein Binding ; Pyridoxal Phosphate/metabolism ; Racemases and Epimerases/antagonists & inhibitors ; Racemases and Epimerases/genetics ; Racemases and Epimerases/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Stereoisomerism ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Pyridoxal kinase inhibition by artemisinins down-regulates inhibitory neurotransmission.
Autorzy :
Kasaragod VB; Institute of Structural Biology, Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, 97080 Würzburg, Germany; .
Pacios-Michelena A; Institute of Structural Biology, Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, 97080 Würzburg, Germany.
Schaefer N; Institute for Clinical Neurobiology, University of Würzburg, 97078 Würzburg, Germany.
Zheng F; Institute of Physiology and Pathophysiology, Friedrich Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.
Bader N; Institute of Structural Biology, Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, 97080 Würzburg, Germany.
Alzheimer C; Institute of Physiology and Pathophysiology, Friedrich Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.
Villmann C; Institute for Clinical Neurobiology, University of Würzburg, 97078 Würzburg, Germany.
Schindelin H; Institute of Structural Biology, Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, 97080 Würzburg, Germany; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 29; Vol. 117 (52), pp. 33235-33245. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*/drug effects
Artemisinins/*pharmacology
Neural Inhibition/*drug effects
Protein Kinase Inhibitors/*pharmacology
Pyridoxal Kinase/*antagonists & inhibitors
Synaptic Transmission/*drug effects
Adenosine Triphosphate/analogs & derivatives ; Adenosine Triphosphate/metabolism ; Animals ; Artemisinins/chemistry ; Binding Sites ; Electrophysiological Phenomena/drug effects ; Female ; GABAergic Neurons/drug effects ; GABAergic Neurons/metabolism ; Glutamate Decarboxylase/metabolism ; Male ; Mice, Inbred C57BL ; Models, Biological ; Models, Molecular ; Protein Kinase Inhibitors/chemistry ; Pyridoxal Kinase/chemistry ; Pyridoxal Kinase/metabolism ; Synapses/drug effects ; Synapses/metabolism ; gamma-Aminobutyric Acid/biosynthesis
Czasopismo naukowe
Tytuł :
Crystallographic Snapshots of the Dunathan and Quinonoid Intermediates provide Insights into the Reaction Mechanism of Group II Decarboxylases.
Autorzy :
Gayathri SC; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India.
Manoj N; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2020 Dec 04; Vol. 432 (24), pp. 166692. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Catalysis*
Protein Conformation*
Pyridoxal Phosphate/*analogs & derivatives
Tyrosine Decarboxylase/*ultrastructure
Aspartate Aminotransferases/chemistry ; Aspartate Aminotransferases/genetics ; Carbon Dioxide/metabolism ; Catalytic Domain/genetics ; Crystallography, X-Ray ; Hydrogen Bonding ; Methanocaldococcus/enzymology ; Pyridoxal Phosphate/chemistry ; Pyridoxal Phosphate/genetics ; Tyrosine Decarboxylase/chemistry ; Tyrosine Decarboxylase/genetics ; Water/chemistry
Czasopismo naukowe
Tytuł :
The Role of YggS in Vitamin B 6 Homeostasis in Salmonella enterica Is Informed by Heterologous Expression of Yeast SNZ3 .
Autorzy :
Vu HN; Department of Microbiology, The University of Georgia, Athens, Georgia, USA.
Ito T; Department of Microbiology, The University of Georgia, Athens, Georgia, USA.
Downs DM; Department of Microbiology, The University of Georgia, Athens, Georgia, USA .
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Źródło :
Journal of bacteriology [J Bacteriol] 2020 Oct 22; Vol. 202 (22). Date of Electronic Publication: 2020 Oct 22 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*metabolism
Carbon-Nitrogen Lyases/*metabolism
Carrier Proteins/*metabolism
Pyridoxal Phosphate/*analogs & derivatives
Saccharomyces cerevisiae Proteins/*metabolism
Salmonella enterica/*metabolism
Vitamin B 6/*metabolism
Bacterial Proteins/genetics ; Biosynthetic Pathways/genetics ; Carbon-Nitrogen Lyases/genetics ; Carrier Proteins/genetics ; Homeostasis ; Mutation ; Pyridoxal Phosphate/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Salmonella enterica/genetics
Czasopismo naukowe
Tytuł :
Regulating the biosynthesis of pyridoxal 5'-phosphate with riboswitch to enhance L-DOPA production by Escherichia coli whole-cell biotransformation.
Autorzy :
Han H; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, Jiangsu, China; Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, Jiangsu, China.
Xu B; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, Jiangsu, China; Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, Jiangsu, China.
Zeng W; Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, Jiangsu, China.
Zhou J; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, Jiangsu, China; Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, Jiangsu, China; Jiangsu Provisional Research Center for Bioactive Product Processing Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, Jiangsu, China. Electronic address: .
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Źródło :
Journal of biotechnology [J Biotechnol] 2020 Sep 10; Vol. 321, pp. 68-77. Date of Electronic Publication: 2020 May 20.
Typ publikacji :
Journal Article
MeSH Terms :
Levodopa*/analysis
Levodopa*/genetics
Levodopa*/metabolism
Pyridoxal Phosphate*/biosynthesis
Pyridoxal Phosphate*/chemistry
Pyridoxal Phosphate*/genetics
Pyridoxal Phosphate*/metabolism
Escherichia coli/*genetics
Riboswitch/*genetics
Biotransformation ; Escherichia coli/metabolism ; Tyrosine Phenol-Lyase/chemistry ; Tyrosine Phenol-Lyase/genetics ; Tyrosine Phenol-Lyase/metabolism
Czasopismo naukowe
Tytuł :
Pyridoxal isonicotinoyl hydrazone inhibition of FXR is involved in the pathogenesis of isoniazid-induced liver injury.
Autorzy :
Zhang G; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou 730000, China.
Chen L; Department of Infectious Disease, the First Hospital of Lanzhou University, Lanzhou 730000, China.
Wen Y; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou 730000, China,; College of Pharmaceutical Science, Lanzhou University, Lanzhou 730000, China.
Rao Z; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou 730000, China.
Wei Y; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou 730000, China.
Wu X; Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou 730000, China,. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Sep 01; Vol. 402, pp. 115134. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chemical and Drug Induced Liver Injury/*metabolism
Hepatocytes/*drug effects
Isoniazid/*analogs & derivatives
Isoniazid/*pharmacology
Pyridoxal/*analogs & derivatives
Receptors, Cytoplasmic and Nuclear/*metabolism
Animals ; Apoptosis/drug effects ; Behavior, Animal/drug effects ; Bile Acids and Salts/metabolism ; Fatty Liver/chemically induced ; Gene Expression Regulation/drug effects ; Humans ; Isoniazid/metabolism ; Male ; Models, Molecular ; Necrosis/chemically induced ; Protein Conformation ; Pyridoxal/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Manganese-Enhanced MRI in Patients with Multiple Sclerosis.
Autorzy :
Suto DJ; From the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Nair G; From the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Sudarshana DM; From the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Steele SU; From the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Dwyer J; From the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Beck ES; From the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Ohayon J; From the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
McFarland H; From the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Koretsky AP; From the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Cortese ICM; From the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Reich DS; From the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland. .
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Źródło :
AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2020 Sep; Vol. 41 (9), pp. 1569-1576. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Contrast Media/*administration & dosage
Edetic Acid/*analogs & derivatives
Magnetic Resonance Imaging/*methods
Multiple Sclerosis/*diagnostic imaging
Pyridoxal Phosphate/*analogs & derivatives
Adult ; Animals ; Edetic Acid/administration & dosage ; Female ; Humans ; Injections, Intravenous ; Male ; Multiple Sclerosis/pathology ; Pilot Projects ; Pyridoxal Phosphate/administration & dosage
Czasopismo naukowe
Tytuł :
Bifunctional pyridoxal derivatives as efficient bioorthogonal reagents for biomacromolecule modifications.
Autorzy :
Mao X; Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China. .
Li W
Zhu S
Zou J
Tian H
Duan Y
Wang Y
Fei J
Wang X
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Źródło :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Jul 14; Vol. 56 (55), pp. 7601-7604. Date of Electronic Publication: 2020 Jun 09.
Typ publikacji :
Journal Article
MeSH Terms :
Green Fluorescent Proteins/*chemistry
Indicators and Reagents/*chemistry
Peptides/*chemistry
Pyridoxal/*analogs & derivatives
Serum Albumin, Bovine/*chemistry
Animals ; Cattle ; Indicators and Reagents/chemical synthesis ; Pyridoxal/chemical synthesis
Czasopismo naukowe
Tytuł :
Evaluation of Leishmania infantum pyridoxal kinase protein for the diagnosis of human and canine visceral leishmaniasis.
Autorzy :
Oliveira-da-Silva JA; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Machado AS; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil; Instituto de Ensino e Pesquisa, Santa Casa de Belo Horizonte. Rua Domingos Vieira, 590, Santa Efigênia, 30150-240, Belo Horizonte, Minas Gerais, Brazil.
Ramos FF; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Tavares GSV; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Lage DP; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Ludolf F; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Steiner BT; Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, 88806-000, Santa Catarina, Brazil.
Reis TAR; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Santos TTO; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Costa LE; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Martins VT; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Galvani NC; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Chaves AT; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Oliveira JS; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Brazil.
Chávez-Fumagalli MA; Universidad Católica de Santa María, Urb. San José S/N, Umacollo, Arequipa, Peru.
de Magalhães-Soares DF; Departamento de Medicina Veterinária Preventiva, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Brazil.
Duarte MC; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Menezes-Souza D; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Silveira JAG; Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Brazil.
Moreira RLF; Fundação Hospitalar do Estado de Minas Gerais, Hospital Eduardo de Menezes, Belo Horizonte, 30622-020, Minas Gerais, Brazil.
Machado-de-Ávila RA; Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, 88806-000, Santa Catarina, Brazil.
Tupinambás U; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Gonçalves DU; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Coelho EAF; Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil. Electronic address: .
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Źródło :
Immunology letters [Immunol Lett] 2020 Apr; Vol. 220, pp. 11-20. Date of Electronic Publication: 2020 Jan 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Protozoan/*blood
Dog Diseases/*diagnosis
Leishmania infantum/*enzymology
Leishmaniasis, Visceral/*diagnosis
Neglected Diseases/*diagnosis
Protozoan Proteins/*immunology
Pyridoxal Kinase/*immunology
Amino Acid Sequence ; Animals ; Antigens, Protozoan/chemistry ; Antigens, Protozoan/genetics ; Antigens, Protozoan/immunology ; Cross Reactions ; Dog Diseases/parasitology ; Dogs ; Enzyme-Linked Immunosorbent Assay ; Epitopes, B-Lymphocyte/chemistry ; Epitopes, B-Lymphocyte/genetics ; Epitopes, B-Lymphocyte/immunology ; Humans ; Leishmania infantum/isolation & purification ; Leishmaniasis, Visceral/veterinary ; Neglected Diseases/parasitology ; Neglected Diseases/veterinary ; Protozoan Proteins/chemistry ; Protozoan Proteins/genetics ; Pyridoxal Kinase/chemistry ; Pyridoxal Kinase/genetics ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Sensitivity and Specificity ; Serologic Tests
Czasopismo naukowe
Tytuł :
Emergence of oxygen- and pyridoxal phosphate-dependent reactions.
Autorzy :
Hoffarth ER; Department of Chemistry, University of British Columbia, Vancouver, BC, Canada.
Rothchild KW; Department of Chemistry, University of British Columbia, Vancouver, BC, Canada.
Ryan KS; Department of Chemistry, University of British Columbia, Vancouver, BC, Canada.
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Źródło :
The FEBS journal [FEBS J] 2020 Apr; Vol. 287 (7), pp. 1403-1428. Date of Electronic Publication: 2020 Mar 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Oxygen/*metabolism
Pyridoxal Phosphate/*metabolism
Humans ; Molecular Structure ; Oxygen/chemistry ; Pyridoxal Phosphate/chemistry
Czasopismo naukowe
Tytuł :
Bioconversion of pyridoxine to pyridoxamine through pyridoxal using a Rhodococcus expression system.
Autorzy :
Yamamura ET; Technical Department, Kyowa Pharma Chemical Co., Ltd., 530 Chokeiji, Takaoka, Toyama 933-8511, Japan. Electronic address: .
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Źródło :
Journal of bioscience and bioengineering [J Biosci Bioeng] 2019 Jan; Vol. 127 (1), pp. 79-84. Date of Electronic Publication: 2018 Jul 26.
Typ publikacji :
Journal Article
MeSH Terms :
Alcohol Oxidoreductases*/genetics
Alcohol Oxidoreductases*/metabolism
Rhodococcus*/genetics
Rhodococcus*/metabolism
Transaminases*/genetics
Transaminases*/metabolism
Metabolic Engineering/*methods
Pyridoxal/*metabolism
Pyridoxamine/*metabolism
Pyridoxine/*metabolism
Biocatalysis ; Gene Expression Regulation, Bacterial ; Organisms, Genetically Modified ; Pyridoxal Phosphate/metabolism ; Vitamin B 6/metabolism
Czasopismo naukowe
Tytuł :
Discovery and Biocatalytic Application of a PLP-Dependent Amino Acid γ-Substitution Enzyme That Catalyzes C-C Bond Formation.
Autorzy :
Chen M; Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, California 90095, United States.
Liu CT; Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, California 90095, United States.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Tang Y; Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095, United States.
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2020 Jun 10; Vol. 142 (23), pp. 10506-10515. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Amino Acids/*metabolism
Carbon-Oxygen Lyases/*metabolism
Oxidoreductases/*metabolism
Pipecolic Acids/*metabolism
Pyridoxal Phosphate/*metabolism
Amino Acids/chemistry ; Biocatalysis ; Carbon-Oxygen Lyases/chemistry ; Molecular Structure ; Oxidoreductases/chemistry ; Pipecolic Acids/chemistry ; Pyridoxal Phosphate/chemistry
Czasopismo naukowe
Tytuł :
Proteomic analysis of pyridoxal oxime derivatives treated Listeria monocytogenes reveals down-regulation of the main virulence factor, Listeriolysin O.
Autorzy :
Šrajer Gajdošik M; Department of Chemistry, J.J. Strossmayer University, HR-31000 Osijek, Croatia. Electronic address: .
Andjelković U; Department of Biotechnology, University of Rijeka, HR-51000 Rijeka, Croatia; Chemical Institute, University of Belgrade, Belgrade, Serbia. Electronic address: .
Gašo-Sokač D; Faculty of Food Technology, J.J. Strossmayer University, HR-31000 Osijek, Croatia. Electronic address: .
Pavlović H; Faculty of Food Technology, J.J. Strossmayer University, HR-31000 Osijek, Croatia. Electronic address: .
Shevchuk O; Department of Biotechnology, University of Rijeka, HR-51000 Rijeka, Croatia; Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Dortmund, Germany. Electronic address: .
Martinović T; Department of Biotechnology, University of Rijeka, HR-51000 Rijeka, Croatia. Electronic address: .
Clifton J; Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI, USA. Electronic address: .
Begić M; Faculty of Medicine, Juraj Dobrila University, HR-52100 Pula, Croatia.
Josić D; Department of Biotechnology, University of Rijeka, HR-51000 Rijeka, Croatia; Faculty of Medicine, Juraj Dobrila University, HR-52100 Pula, Croatia; Department of Medicine, Warren Alpert Medical School, Brown University, Providence, RI, USA. Electronic address: .
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Źródło :
Food research international (Ottawa, Ont.) [Food Res Int] 2020 May; Vol. 131, pp. 108951. Date of Electronic Publication: 2019 Dec 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Toxins/*metabolism
Gene Expression Regulation, Bacterial/*drug effects
Heat-Shock Proteins/*metabolism
Hemolysin Proteins/*metabolism
Listeria monocytogenes/*drug effects
Listeria monocytogenes/*metabolism
Pyridoxal/*analogs & derivatives
Bacterial Toxins/genetics ; Chromatography, Liquid ; Down-Regulation ; Heat-Shock Proteins/genetics ; Hemolysin Proteins/genetics ; Proteomics ; Pyridoxal/pharmacology ; Tandem Mass Spectrometry/methods
Czasopismo naukowe
Tytuł :
Structural Analysis of an l-Cysteine Desulfurase from an Ssp DNA Phosphorothioation System.
Autorzy :
Liu L; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Joint International Research Laboratory of Metabolic & Developmental Sciences, Shanghai Jiao Tong University, Shanghai, China.; Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China.; Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, China.
Jiang S; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China.; Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, China.
Xing M; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China.; Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, China.
Chen C; Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China.; Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, China.
Lai C; Jiangxi Engineering Laboratory for the Development and Utilization of Agricultural Microbial Resources, College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang, China.
Li N; National Facility for Protein Science Shanghai, Zhangjiang Lab, Shanghai, China.
Liu G; National Facility for Protein Science Shanghai, Zhangjiang Lab, Shanghai, China.
Wu D; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China.
Gao H; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China.
Hong L; School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China.
Tan P; School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China.
Chen S; Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China.; Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, China.
Deng Z; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Joint International Research Laboratory of Metabolic & Developmental Sciences, Shanghai Jiao Tong University, Shanghai, China.; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China.
Wu G; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Joint International Research Laboratory of Metabolic & Developmental Sciences, Shanghai Jiao Tong University, Shanghai, China .
Wang L; Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China .; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China.; Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, China.
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Źródło :
MBio [mBio] 2020 Apr 28; Vol. 11 (2). Date of Electronic Publication: 2020 Apr 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carbon-Sulfur Lyases/*chemistry
DNA/*chemistry
Pyridoxal Phosphate/*metabolism
Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Carbon-Sulfur Lyases/metabolism ; Catalytic Domain ; Crystallography, X-Ray ; Cysteine/chemistry ; Cysteine/metabolism ; DNA/metabolism ; Iron-Sulfur Proteins/chemistry ; Iron-Sulfur Proteins/metabolism ; Molecular Dynamics Simulation ; Phosphorothioate Oligonucleotides/chemistry ; Pyridoxal Phosphate/chemistry ; Sulfur/metabolism ; Vibrio/metabolism
SCR Organism :
Vibrio cyclitrophicus
Czasopismo naukowe

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