Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Pyrimethamine"" wg kryterium: Temat


Tytuł :
Targeting constitutively active STAT3 in chronic lymphocytic leukemia: A clinical trial of the STAT3 inhibitor pyrimethamine with pharmacodynamic analyses.
Autorzy :
Brown JR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Walker SR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Heppler LN; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Tyekucheva S; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Nelson EA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Klitgaard J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Nicolais M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Kroll Y; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Xiang M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Yeh JE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Chaudhury M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Giaccone ZT; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Fernandes SM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Jacobsen ED; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Fisher DC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Freedman AS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Davids MS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Supko JG; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Wu C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Frank DA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Pokaż więcej
Źródło :
American journal of hematology [Am J Hematol] 2021 Apr 01; Vol. 96 (4), pp. E95-E98. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Clinical Trial; Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Leukemia, Lymphocytic, Chronic, B-Cell/*drug therapy
Neoplasm Proteins/*antagonists & inhibitors
Pyrimethamine/*therapeutic use
STAT3 Transcription Factor/*antagonists & inhibitors
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/administration & dosage ; B-Lymphocytes/drug effects ; B-Lymphocytes/metabolism ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Drug Repositioning ; Drug Screening Assays, Antitumor ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Leukemic/drug effects ; Humans ; Male ; Middle Aged ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/genetics ; Progression-Free Survival ; Pyrimethamine/administration & dosage ; Pyrimethamine/pharmacology
Raport
Tytuł :
Deleterious effects of malaria in pregnancy on the developing fetus: a review on prevention and treatment with antimalarial drugs.
Autorzy :
Saito M; Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Briand V; Infectious Diseases in Lower Income Countries, Research Institute for Sustainable Development, French National Institute of Health and Medical Research, University of Bordeaux, Bordeaux, France.
Min AM; Shoklo Malaria Research Unit, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.
McGready R; Shoklo Malaria Research Unit, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Electronic address: .
Pokaż więcej
Źródło :
The Lancet. Child & adolescent health [Lancet Child Adolesc Health] 2020 Oct; Vol. 4 (10), pp. 761-774.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antimalarials/*therapeutic use
Malaria/*drug therapy
Pregnancy Complications, Parasitic/*drug therapy
Pyrimethamine/*therapeutic use
Sulfadoxine/*therapeutic use
Abnormalities, Drug-Induced/prevention & control ; Antimalarials/adverse effects ; Drug Administration Schedule ; Drug Combinations ; Female ; Humans ; Malaria/prevention & control ; Observational Studies as Topic ; Pregnancy ; Pyrimethamine/adverse effects ; Sulfadoxine/adverse effects ; Systematic Reviews as Topic
Czasopismo naukowe
Tytuł :
Impact of intermittent preventive treatment of malaria in pregnancy with dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine on the incidence of malaria in infancy: a randomized controlled trial.
Autorzy :
Kakuru A; London School of Hygiene and Tropical Medicine, London, UK. .; Infectious Diseases Research Collaboration, Kampala, Uganda. .
Jagannathan P; Department of Medicine, Stanford University, Stanford, USA.
Kajubi R; Infectious Diseases Research Collaboration, Kampala, Uganda.
Ochieng T; Infectious Diseases Research Collaboration, Kampala, Uganda.
Ochokoru H; Infectious Diseases Research Collaboration, Kampala, Uganda.
Nakalembe M; Department of Obstetrics and Gynaecology, Makerere University College of Health Sciences, Kampala, Uganda.
Clark TD; Department of Medicine, University of California, San Francisco, USA.
Ruel T; Department of Paediatrics, University of California, San Francisco, USA.
Staedke SG; London School of Hygiene and Tropical Medicine, London, UK.
Chandramohan D; London School of Hygiene and Tropical Medicine, London, UK.
Havlir DV; Department of Medicine, University of California, San Francisco, USA.
Kamya MR; School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Dorsey G; Department of Medicine, University of California, San Francisco, USA.
Pokaż więcej
Źródło :
BMC medicine [BMC Med] 2020 Aug 10; Vol. 18 (1), pp. 207. Date of Electronic Publication: 2020 Aug 10.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antimalarials/*therapeutic use
Artesunate/*therapeutic use
Malaria/*drug therapy
Malaria/*prevention & control
Pregnancy Complications, Parasitic/*drug therapy
Pregnancy Complications, Parasitic/*prevention & control
Pyrimethamine/*therapeutic use
Sulfadoxine/*therapeutic use
Adult ; Antimalarials/pharmacology ; Artesunate/pharmacology ; Double-Blind Method ; Drug Combinations ; Female ; Humans ; Incidence ; Infant ; Infant, Newborn ; Malaria/epidemiology ; Male ; Pregnancy ; Pyrimethamine/pharmacology ; Sulfadoxine/pharmacology ; Young Adult
Czasopismo naukowe
Tytuł :
Malaria intermittent preventive treatment in Nigeria: a qualitative study to explore barriers.
Autorzy :
Muhammad FM; Department of Epidemiology & Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Nedjat S; Department of Epidemiology & Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Sajadi HS; Knowledge Utilization Research Center, University Research and Development Center, Tehran University of Medical Sciences, Tehran, Iran.
Parsaeian M; Department of Epidemiology & Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Assan A; Global Policy & Advocacy Network (GLOOPLAN), Accra, Ghana.
Majdzadeh R; Department of Epidemiology & Biostatistics, School of Public Health, Knowledge Utilization Research Center and Community-Based Participatory-Research-Center, Tehran University of Medical Sciences, Tehran, Iran. .
Pokaż więcej
Źródło :
BMC infectious diseases [BMC Infect Dis] 2021 May 13; Vol. 21 (1), pp. 438. Date of Electronic Publication: 2021 May 13.
Typ publikacji :
Journal Article
MeSH Terms :
Antimalarials/*therapeutic use
Malaria/*prevention & control
Pregnancy Complications, Parasitic/*prevention & control
Adolescent ; Adult ; Delivery of Health Care ; Drug Combinations ; Female ; Focus Groups ; Humans ; Malaria/epidemiology ; Male ; Nigeria ; Pregnancy ; Pregnancy Complications, Parasitic/epidemiology ; Pyrimethamine/therapeutic use ; Qualitative Research ; Sulfadoxine/therapeutic use ; Young Adult
Czasopismo naukowe
Tytuł :
Prevalence of pfdhfr and pfdhps mutations in Plasmodium falciparum associated with drug resistance among pregnant women receiving IPTp-SP at Msambweni County Referral Hospital, Kwale County, Kenya.
Autorzy :
Gikunju SW; Jomo Kenyatta University of Agriculture and Technology (JKUAT), Nairobi, Kenya. .; Kenya Medical Research Institute (KEMRI), Centre for Biotechnology Research and Development (CBRD), Nairobi, Kenya. .
Agola EL; Kenya Medical Research Institute (KEMRI), Centre for Biotechnology Research and Development (CBRD), Nairobi, Kenya.; Technical University of Kenya, Nairobi, Kenya.
Ondondo RO; Masinde Muliro University of Science and Technology, Kakamega, Kenya.
Kinyua J; Jomo Kenyatta University of Agriculture and Technology (JKUAT), Nairobi, Kenya.
Kimani F; Kenya Medical Research Institute (KEMRI), Centre for Biotechnology Research and Development (CBRD), Nairobi, Kenya.
LaBeaud AD; Department of Pediatrics, Division of Infectious Disease, Stanford University School of Medicine, Stanford, CA, USA.
Malhotra I; Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, USA.
King C; Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, USA.
Thiong'o K; Kenya Medical Research Institute (KEMRI), Centre for Biotechnology Research and Development (CBRD), Nairobi, Kenya.
Mutuku F; Department of Environment and Health Sciences, Technical University of Mombasa, Mombasa, Kenya.
Pokaż więcej
Źródło :
Malaria journal [Malar J] 2020 May 24; Vol. 19 (1), pp. 190. Date of Electronic Publication: 2020 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Antimalarials/*pharmacology
Drug Resistance/*genetics
Plasmodium falciparum/*genetics
Protozoan Proteins/*genetics
Pyrimethamine/*pharmacology
Sulfadoxine/*pharmacology
Tetrahydrofolate Dehydrogenase/*genetics
Adult ; Antimalarials/therapeutic use ; Drug Combinations ; Female ; Genetic Markers ; Humans ; Kenya/epidemiology ; Malaria, Falciparum/epidemiology ; Mutation ; Pregnancy ; Prevalence ; Protozoan Proteins/metabolism ; Pyrimethamine/therapeutic use ; Sulfadoxine/therapeutic use ; Tetrahydrofolate Dehydrogenase/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Pyrimethamine conjugated histone deacetylase inhibitors: Design, synthesis and evidence for triple negative breast cancer selective cytotoxicity.
Autorzy :
Wu B; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332-0400 USA.
Fathi S; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332-0400 USA.
Mortley S; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332-0400 USA.
Mohiuddin M; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332-0400 USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0400 USA.
Jang YC; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332-0400 USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0400 USA.
Oyelere AK; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332-0400 USA; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332-0400 USA. Electronic address: .
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 Mar 15; Vol. 28 (6), pp. 115345. Date of Electronic Publication: 2020 Jan 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Histone Deacetylase Inhibitors/*pharmacology
Pyrimethamine/*pharmacology
Triple Negative Breast Neoplasms/*drug therapy
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cells, Cultured ; Chlorocebus aethiops ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Humans ; Molecular Structure ; Pyrimethamine/chemical synthesis ; Pyrimethamine/chemistry ; STAT3 Transcription Factor/antagonists & inhibitors ; STAT3 Transcription Factor/metabolism ; Structure-Activity Relationship ; Triple Negative Breast Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
A new effective antiplasmodial compound: Nanoformulated pyrimethamine.
Autorzy :
Pestehchian N; Department of Parasitology and Mycology, School of Medicine and Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Vafaei MR; Department of Parasitology and Mycology, School of Medicine and Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Nematolahy P; Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Varshosaz J; Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: .
Yousefi HA; Department of Parasitology and Mycology, School of Medicine and Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Bide VZ; Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Kalani H; Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Electronic address: .
Pokaż więcej
Źródło :
Journal of global antimicrobial resistance [J Glob Antimicrob Resist] 2020 Mar; Vol. 20, pp. 309-315. Date of Electronic Publication: 2019 Aug 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antimalarials/*administration & dosage
Malaria/*drug therapy
Parasitemia/*drug therapy
Plasmodium berghei/*drug effects
Poloxamer/*chemistry
Pyrimethamine/*administration & dosage
Animals ; Antimalarials/chemical synthesis ; Antimalarials/chemistry ; Antimalarials/pharmacology ; Disease Models, Animal ; Drug Compounding ; Liver/drug effects ; Liver/parasitology ; Male ; Mice ; Micelles ; Nanoparticles ; Particle Size ; Plasmodium berghei/pathogenicity ; Pyrimethamine/chemical synthesis ; Pyrimethamine/chemistry ; Pyrimethamine/pharmacology ; Random Allocation ; Spleen/drug effects ; Spleen/parasitology ; Survival Analysis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
High Prevalence of Molecular Markers of Plasmodium falciparum Resistance to Sulphadoxine-Pyrimethamine in Parts of Ghana: A Threat to ITPTp-SP?
Autorzy :
Afutu LL
Boampong JN; Department of Biomedical Science, School of Allied Health Sciences, College of Health and Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.
Quashie NB; Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, Accra, Ghana.; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana.
Pokaż więcej
Źródło :
Journal of tropical pediatrics [J Trop Pediatr] 2021 Jan 29; Vol. 67 (1).
Typ publikacji :
Journal Article
MeSH Terms :
Antimalarials*/pharmacology
Antimalarials*/therapeutic use
Malaria, Falciparum*/drug therapy
Malaria, Falciparum*/epidemiology
Child ; Drug Combinations ; Drug Resistance/genetics ; Female ; Ghana/epidemiology ; Humans ; Plasmodium falciparum/genetics ; Pregnancy ; Prevalence ; Pyrimethamine/pharmacology ; Pyrimethamine/therapeutic use ; Sulfadoxine/pharmacology
Czasopismo naukowe
Tytuł :
Effect of group versus individual antenatal care on uptake of intermittent prophylactic treatment of malaria in pregnancy and related malaria outcomes in Nigeria and Kenya: analysis of data from a pragmatic cluster randomized trial.
Autorzy :
Noguchi L; Jhpiego, 1615 Thames Street, Baltimore, MD, 21231, USA. .
Grenier L; Jhpiego, 1615 Thames Street, Baltimore, MD, 21231, USA.
Kabue M; Jhpiego, 1615 Thames Street, Baltimore, MD, 21231, USA.
Ugwa E; Jhpiego Nigeria, Plot 971 Reuben Okoya Crescent, Utako, Abuja, Nigeria.
Oyetunji J; Jhpiego Nigeria, Plot 971 Reuben Okoya Crescent, Utako, Abuja, Nigeria.
Suhowatsky S; Jhpiego, 1615 Thames Street, Baltimore, MD, 21231, USA.
Onguti B; Jhpiego Kenya, Ring Road, 14 Riverside, Nairobi, Kenya.
Orji B; Jhpiego Nigeria, Plot 971 Reuben Okoya Crescent, Utako, Abuja, Nigeria.
Whiting-Collins L; Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA.
Adetiloye O; Jhpiego Nigeria, Plot 971 Reuben Okoya Crescent, Utako, Abuja, Nigeria.
Pokaż więcej
Źródło :
Malaria journal [Malar J] 2020 Jan 29; Vol. 19 (1), pp. 51. Date of Electronic Publication: 2020 Jan 29.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Antimalarials/*therapeutic use
Malaria/*prevention & control
Pregnancy Complications, Parasitic/*prevention & control
Prenatal Care/*methods
Pyrimethamine/*therapeutic use
Sulfadoxine/*therapeutic use
Adolescent ; Adult ; Antimalarials/administration & dosage ; Cluster Analysis ; Cohort Studies ; Drug Combinations ; Female ; Humans ; Infant ; Infant, Newborn ; Insecticide-Treated Bednets ; Kenya/epidemiology ; Malaria/epidemiology ; Nigeria/epidemiology ; Pregnancy ; Pregnancy Complications, Parasitic/epidemiology ; Pyrimethamine/administration & dosage ; Sulfadoxine/administration & dosage ; Young Adult
Czasopismo naukowe
Tytuł :
Phylogenetic analysis suggests single and multiple origins of dihydrofolate reductase mutations in Plasmodium vivax.
Autorzy :
Shaukat A; University of Central Punjab, Lahore, Pakistan.
Ali Q; Gomal University, Dera Ismail Khan, Pakistan.
Raud L; University of Edinburgh, UK.
Wahab A; Kohat University of Science and Technology, Pakistan.
Khan TA; Kohat University of Science and Technology, Pakistan.
Rashid I; University of Veterinary and Animal Sciences, Lahore, Punjab, Pakistan.
Rashid M; PCMD, University of Karachi, Pakistan.
Hussain M; Kohat University of Science and Technology, Pakistan.
Saleem MA; University of Central Punjab, Lahore, Pakistan.
Sargison ND; University of Edinburgh, UK.
Chaudhry U; University of Edinburgh, UK; University of Surrey, United Kingdom. Electronic address: .
Pokaż więcej
Źródło :
Acta tropica [Acta Trop] 2021 Mar; Vol. 215, pp. 105821. Date of Electronic Publication: 2021 Jan 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Mutation*
Phylogeny*
Plasmodium vivax/*genetics
Tetrahydrofolate Dehydrogenase/*genetics
Antimalarials/therapeutic use ; Drug Resistance/genetics ; Humans ; Malaria, Vivax/drug therapy ; Plasmodium vivax/enzymology ; Pyrimethamine/pharmacology
Czasopismo naukowe
Tytuł :
Late ANC initiation and factors associated with sub-optimal uptake of sulphadoxine-pyrimethamine in pregnancy: a preliminary study in Cape Coast Metropolis, Ghana.
Autorzy :
Amoako BK; School of Public Health, University of Ghana, Legon, Accra, Ghana.; Cape Coast Metropolitan Health Directorate, Cape Coast, Ghana.
Anto F; School of Public Health, University of Ghana, Legon, Accra, Ghana. .
Pokaż więcej
Źródło :
BMC pregnancy and childbirth [BMC Pregnancy Childbirth] 2021 Feb 02; Vol. 21 (1), pp. 105. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article
MeSH Terms :
Antimalarials/*therapeutic use
Malaria/*prevention & control
Patient Acceptance of Health Care/*statistics & numerical data
Pregnancy Complications, Parasitic/*prevention & control
Pyrimethamine/*therapeutic use
Sulfadoxine/*therapeutic use
Adolescent ; Adult ; Cross-Sectional Studies ; Drug Combinations ; Female ; Ghana ; Humans ; Pregnancy ; Prenatal Care/statistics & numerical data ; Young Adult
Czasopismo naukowe
Tytuł :
Identification of Appropriate Endogenous Biomarker for Risk Assessment of Multidrug and Toxin Extrusion Protein-Mediated Drug-Drug Interactions in Healthy Volunteers.
Autorzy :
Miyake T; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Kimoto E; ADME Sciences, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
Luo L; ADME Sciences, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
Mathialagan S; ADME Sciences, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
Horlbogen LM; ADME Sciences, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
Ramanathan R; ADME Sciences, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
Wood LS; Clinical Pharmacogenomics Laboratory, Early Clinical Development, Pfizer Inc, Groton, Connecticut, USA.
Johnson JG; Clinical Pharmacogenomics Laboratory, Early Clinical Development, Pfizer Inc, Groton, Connecticut, USA.
Le VH; Biostatics, Pfizer Inc., Collegeville, Pennsylvania, USA.
Vourvahis M; Clinical Pharmacology, Pfizer Inc., New York, New York, USA.
Rodrigues AD; ADME Sciences, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
Muto C; Clinical Pharmacology, Pfizer R&D Japan, Tokyo, Japan.
Furihata K; P-One Clinic, Keikokai Medical Corp, Tokyo, Japan.
Sugiyama Y; Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, RIKEN, Yokohama, Kanagawa, Japan.
Kusuhara H; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Pokaż więcej
Źródło :
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2021 Feb; Vol. 109 (2), pp. 507-516. Date of Electronic Publication: 2020 Oct 09.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biomarkers/*metabolism
Drug Interactions/*physiology
Organic Cation Transport Proteins/*metabolism
Adult ; Asian Continental Ancestry Group ; Cell Line ; Creatinine/metabolism ; Cross-Over Studies ; HEK293 Cells ; Healthy Volunteers ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/blood ; Hypoglycemic Agents/metabolism ; Kidney/metabolism ; Male ; Metformin/therapeutic use ; Pyrimethamine/administration & dosage ; Pyrimethamine/blood ; Pyrimethamine/metabolism ; Risk Assessment ; Young Adult
Czasopismo naukowe
Tytuł :
Inequities in the use of sulphadoxine-pyrimethamine for malaria prophylaxis during pregnancy in Nigeria.
Autorzy :
Ndu A; Department of Community Medicine, College of Medicine, University of Nigeria Enugu campus. PMB 01129, Enugu, Nigeria.; Institute of Public Health, College of Medicine, University of Nigeria Enugu campus. PMB 01129, Enugu, Nigeria.
Mbachu C; Department of Community Medicine, College of Medicine, University of Nigeria Enugu campus. PMB 01129, Enugu, Nigeria.; Institute of Public Health, College of Medicine, University of Nigeria Enugu campus. PMB 01129, Enugu, Nigeria.; Health Policy Research Group, University of Nigeria Enugu campus. PMB 01129, Enugu, Nigeria.
Anitube O; Institute of Public Health, College of Medicine, University of Nigeria Enugu campus. PMB 01129, Enugu, Nigeria.; Health Policy Research Group, University of Nigeria Enugu campus. PMB 01129, Enugu, Nigeria.
Ezeoke U; Department of Community Medicine, College of Medicine, University of Nigeria Enugu campus. PMB 01129, Enugu, Nigeria.; Institute of Public Health, College of Medicine, University of Nigeria Enugu campus. PMB 01129, Enugu, Nigeria.
Pokaż więcej
Źródło :
Malawi medical journal : the journal of Medical Association of Malawi [Malawi Med J] 2020 Mar; Vol. 32 (1), pp. 45-51.
Typ publikacji :
Journal Article
MeSH Terms :
Healthcare Disparities*
Antimalarials/*administration & dosage
Health Services Accessibility/*statistics & numerical data
Malaria/*prevention & control
Pregnancy Complications, Parasitic/*prevention & control
Prenatal Care/*statistics & numerical data
Pyrimethamine/*administration & dosage
Sulfadoxine/*administration & dosage
Adolescent ; Adult ; Antimalarials/therapeutic use ; Drug Combinations ; Female ; Health Care Surveys ; Humans ; Middle Aged ; Nigeria ; Patient Acceptance of Health Care/statistics & numerical data ; Pregnancy ; Pregnancy Complications, Parasitic/drug therapy ; Pyrimethamine/therapeutic use ; Sulfadoxine/therapeutic use ; Young Adult
Czasopismo naukowe
Tytuł :
CNT-based nanocarrier loaded with pyrimethamine for adipose mesenchymal stem cells differentiation and cancer treatment: The computational and experimental methods.
Autorzy :
Mollania F; Department of Chemistry, Faculty of Science, Tarbiat Modares University, P. O. Box, 14115-175, Tehran, Iran. Electronic address: .
Hadipour NL; Department of Chemistry, Faculty of Science, Tarbiat Modares University, P. O. Box, 14115-175, Tehran, Iran. Electronic address: .
Mollania N; Department of Biology, Faculty of Basic Sciences, Hakim Sabzevari University, Sabzevar, Iran.
Pokaż więcej
Źródło :
Journal of biotechnology [J Biotechnol] 2020 Jan 20; Vol. 308, pp. 40-55. Date of Electronic Publication: 2019 Nov 07.
Typ publikacji :
Journal Article
MeSH Terms :
Adipose Tissue/*cytology
Antineoplastic Agents/*pharmacology
Neurons/*cytology
Pyrimethamine/*pharmacology
Adipose Tissue/drug effects ; Antineoplastic Agents/chemistry ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Gene Expression Regulation/drug effects ; Humans ; MCF-7 Cells ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/drug effects ; Molecular Conformation ; Nanotubes, Carbon ; Neurofilament Proteins/genetics ; Neurons/drug effects ; Phosphopyruvate Hydratase/genetics ; Pyrimethamine/chemistry
Czasopismo naukowe
Tytuł :
"They Merely Prescribe and I Merely Swallow": Perceptions of Antenatal Pharmaceuticals and Nutritional Supplements Among Pregnant Women in Bamako, Mali.
Autorzy :
Searle AR; Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA. .
Hurley EA; Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA.; Health Services and Outcomes Research, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA.
Doumbia SO; Faculty of Medicine and Odontostomatology, University of Sciences, Techniques, and Technologies of Bamako, Bamako, Mali.
Winch PJ; Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA.
Pokaż więcej
Źródło :
Maternal and child health journal [Matern Child Health J] 2020 Jan; Vol. 24 (1), pp. 110-120.
Typ publikacji :
Journal Article
MeSH Terms :
Antiretroviral Therapy, Highly Active*
Health Knowledge, Attitudes, Practice*
Antimalarials/*administration & dosage
HIV Infections/*prevention & control
Iron/*administration & dosage
Malaria/*prevention & control
Pregnancy Complications, Infectious/*prevention & control
Pregnancy Complications, Parasitic/*prevention & control
Pregnant Women/*psychology
Prenatal Care/*methods
Pyrimethamine/*administration & dosage
Sulfadoxine/*administration & dosage
Adult ; Antimalarials/therapeutic use ; Drug Combinations ; Female ; HIV Infections/drug therapy ; Humans ; Iron/therapeutic use ; Mali ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; Pregnancy Complications, Parasitic/drug therapy ; Prescriptions ; Pyrimethamine/therapeutic use ; Qualitative Research ; Quality of Health Care ; Sulfadoxine/therapeutic use
Czasopismo naukowe
Tytuł :
6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum.
Autorzy :
Saepua S; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand.
Sadorn K; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand.
Vanichtanankul J; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand.
Anukunwithaya T; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand.
Rattanajak R; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand.
Vitsupakorn D; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand.
Kamchonwongpaisan S; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand.
Yuthavong Y; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand.
Thongpanchang C; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathumthani 12120, Thailand. Electronic address: .
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2019 Dec 15; Vol. 27 (24), pp. 115158. Date of Electronic Publication: 2019 Oct 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antimalarials/*pharmacology
Plasmodium falciparum/*drug effects
Pyrimethamine/*analogs & derivatives
Animals ; Antimalarials/chemistry ; Chlorocebus aethiops ; Drug Design ; Drug Resistance ; Folic Acid Antagonists/chemistry ; Folic Acid Antagonists/pharmacology ; Models, Molecular ; Molecular Structure ; Protein Conformation ; Pyrimethamine/chemistry ; Pyrimethamine/pharmacology ; Tetrahydrofolate Dehydrogenase/chemistry ; Tetrahydrofolate Dehydrogenase/metabolism ; Vero Cells
Czasopismo naukowe
Tytuł :
Polymerase-guided base editing enables in vivo mutagenesis and rapid protein engineering.
Autorzy :
Cravens A; Department of Bioengineering, 443 Via Ortega, MC 4245, Stanford University, Stanford, CA, USA.
Jamil OK; Department of Chemical Engineering, 443 Via Ortega, MC 4245, Stanford University, Stanford, CA, USA.
Kong D; Department of Bioengineering, 443 Via Ortega, MC 4245, Stanford University, Stanford, CA, USA.
Sockolosky JT; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Smolke CD; Department of Bioengineering, 443 Via Ortega, MC 4245, Stanford University, Stanford, CA, USA. .; Chan Zuckerberg Biohub, San Francisco, CA, USA. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 Mar 11; Vol. 12 (1), pp. 1579. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA-Directed RNA Polymerases/*metabolism
Directed Molecular Evolution/*methods
Drug Resistance, Fungal/*genetics
Protein Engineering/*methods
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Viral Proteins/*metabolism
Antifungal Agents/pharmacology ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Mutagenesis/genetics ; Promoter Regions, Genetic/genetics ; Pyrimethamine/pharmacology
Czasopismo naukowe
Tytuł :
Factors affecting uptake of ≥ 3 doses of Sulfadoxine-Pyrimethamine for malaria prevention in pregnancy in selected health facilities, Arusha region, Tanzania.
Autorzy :
Mchwampaka WM; Mount Meru Regional Referral Hospital (MMRRH), Preventive Section, P.O. Box 3010, Arusha, Tanzania. .
Tarimo D; Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania.
Chacky F; Tanzania National Malaria Control Programme (NMCP), Dar es Salaam, Tanzania.
Mohamed A; Tanzania Field Epidemiology and Laboratory Training Programme (TFELTP), Dar es Salaam, Tanzania.
Kishimba R; Tanzania Field Epidemiology and Laboratory Training Programme (TFELTP), Dar es Salaam, Tanzania.; Ministry of Health, Community Development, Gender, Elderly and Children (MoHCDGEC), Dar es Salaam, Tanzania.
Samwel A; Tanzania Field Epidemiology and Laboratory Training Programme (TFELTP), Dar es Salaam, Tanzania.
Pokaż więcej
Źródło :
BMC pregnancy and childbirth [BMC Pregnancy Childbirth] 2019 Nov 27; Vol. 19 (1), pp. 440. Date of Electronic Publication: 2019 Nov 27.
Typ publikacji :
Journal Article
MeSH Terms :
Health Knowledge, Attitudes, Practice*
Antimalarials/*administration & dosage
Pregnancy Complications, Parasitic/*prevention & control
Pregnant Women/*psychology
Prenatal Care/*statistics & numerical data
Pyrimethamine/*administration & dosage
Sulfadoxine/*administration & dosage
Adolescent ; Adult ; Antimalarials/supply & distribution ; Cross-Sectional Studies ; Directly Observed Therapy/statistics & numerical data ; Drug Combinations ; Educational Status ; Female ; Health Facilities ; Health Personnel/psychology ; Humans ; Interviews as Topic ; Male ; Middle Aged ; Patient Acceptance of Health Care/statistics & numerical data ; Pregnancy ; Pregnancy Trimester, First ; Pyrimethamine/supply & distribution ; Sulfadoxine/supply & distribution ; Surveys and Questionnaires ; Tanzania ; Young Adult
Czasopismo naukowe
Tytuł :
Absence of K13 gene mutations among artesunate/sulfadoxine-pyrimethamine treatment failures of Sudanese Plasmodium falciparum isolates from Damazin, southeast Sudan.
Autorzy :
Abdel Hamid MM; Institute of Endemic Diseases, Medical Campus, University of Khartoum, Khartoum, Sudan.
Abdallah WME; Institute of Endemic Diseases, Medical Campus, University of Khartoum, Khartoum, Sudan.
Hussien M; Institute of Endemic Diseases, Medical Campus, University of Khartoum, Khartoum, Sudan.
Mohammed NM; Institute of Endemic Diseases, Medical Campus, University of Khartoum, Khartoum, Sudan.
Malik EM; Faculty of Medicine, Medical Campus, University of Khartoum, Khartoum, Sudan.
Ahmed ME; Faculty of Medicine, Alnaileen University, Khartoum, Sudan.
Mohamed AO; Institute of Endemic Diseases, Medical Campus, University of Khartoum, Khartoum, Sudan.; Faculty of Medicine, Medical Campus, University of Khartoum, Khartoum, Sudan.
Pokaż więcej
Źródło :
Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2019 Jul 01; Vol. 113 (7), pp. 428-430.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Treatment Failure*
Antimalarials/*pharmacology
Artemisinins/*pharmacology
Malaria, Falciparum/*drug therapy
Plasmodium falciparum/*drug effects
Plasmodium falciparum/*genetics
Polymorphism, Genetic/*genetics
Pyrimethamine/*pharmacology
Sulfadoxine/*pharmacology
Antimalarials/therapeutic use ; Artemisinins/therapeutic use ; Drug Resistance, Multiple/genetics ; Humans ; Plasmodium falciparum/isolation & purification ; Pyrimethamine/therapeutic use ; Sudan ; Sulfadoxine/therapeutic use
Czasopismo naukowe
Tytuł :
Efficacy of sulfadiazine and pyrimetamine for treatment of experimental toxoplasmosis with strains obtained from human cases of congenital disease in Brazil.
Autorzy :
Silva LA; Laboratório de Toxoplasmose, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Fernandes MD; Laboratório de Toxoplasmose, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Machado AS; Laboratório de Toxoplasmose, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Reis-Cunha JL; Laboratório de Imunologia e Genômica de Parasitos, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Bartholomeu DC; Laboratório de Imunologia e Genômica de Parasitos, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Almeida Vitor RW; Laboratório de Toxoplasmose, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: .
Pokaż więcej
Źródło :
Experimental parasitology [Exp Parasitol] 2019 Jul; Vol. 202, pp. 7-14. Date of Electronic Publication: 2019 May 08.
Typ publikacji :
Journal Article
MeSH Terms :
Antiprotozoal Agents/*therapeutic use
Pyrimethamine/*therapeutic use
Sulfadiazine/*therapeutic use
Toxoplasmosis, Animal/*drug therapy
Toxoplasmosis, Congenital/*parasitology
Alcohol Dehydrogenase/genetics ; Animals ; Antiprotozoal Agents/pharmacology ; Female ; Genotype ; Humans ; Infant, Newborn ; Mice ; Pyrimethamine/pharmacology ; Sulfadiazine/pharmacology ; Toxoplasma/classification ; Toxoplasma/drug effects ; Toxoplasma/genetics ; Toxoplasma/pathogenicity ; Toxoplasmosis, Animal/parasitology ; Toxoplasmosis, Congenital/drug therapy ; Virulence
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies